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Aliases for RGPD4 Gene

Aliases for RGPD4 Gene

  • RANBP2-Like And GRIP Domain Containing 4 2 3
  • RGP4 3 4

External Ids for RGPD4 Gene

Previous GeneCards Identifiers for RGPD4 Gene

  • GC02U900817
  • GC02M087836
  • GC02P107810
  • GC02P109910
  • GC02P108443

Summaries for RGPD4 Gene

GeneCards Summary for RGPD4 Gene

RGPD4 (RANBP2-Like And GRIP Domain Containing 4) is a Protein Coding gene. Diseases associated with RGPD4 include mesenchymal cell neoplasm. Among its related pathways are RNA transport. An important paralog of this gene is PPIE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD4 Gene

Genomics for RGPD4 Gene

Regulatory Elements for RGPD4 Gene

Genomic Location for RGPD4 Gene

107,826,932 bp from pter
107,892,544 bp from pter
65,613 bases
Plus strand

Genomic View for RGPD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD4 Gene

Proteins for RGPD4 Gene

  • Protein details for RGPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RanBP2-like and GRIP domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B9A029

    Protein attributes for RGPD4 Gene

    1758 amino acids
    Molecular mass:
    197289 Da
    Quaternary structure:
    No Data Available
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere

    Alternative splice isoforms for RGPD4 Gene


neXtProt entry for RGPD4 Gene

Proteomics data for RGPD4 Gene at MOPED

Post-translational modifications for RGPD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGPD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGPD4 Gene

Domains & Families for RGPD4 Gene

Gene Families for RGPD4 Gene

Protein Domains for RGPD4 Gene

Suggested Antigen Peptide Sequences for RGPD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRIP domain.
  • Contains 2 TPR repeats.
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with RGPD4: view

Function for RGPD4 Gene

Gene Ontology (GO) - Molecular Function for RGPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGPD4: view

Phenotypes for RGPD4 Gene

genes like me logo Genes that share phenotypes with RGPD4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RGPD4 Gene

Localization for RGPD4 Gene

Subcellular locations from

Jensen Localization Image for RGPD4 Gene COMPARTMENTS Subcellular localization image for RGPD4 gene
Compartment Confidence
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RGPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGPD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGPD4 Gene

Pathways & Interactions for RGPD4 Gene

SuperPathways for RGPD4 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD4: view

Pathways by source for RGPD4 Gene

1 KEGG pathway for RGPD4 Gene

Gene Ontology (GO) - Biological Process for RGPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD4: view

No data available for SIGNOR curated interactions for RGPD4 Gene

Drugs & Compounds for RGPD4 Gene

No Compound Related Data Available

Transcripts for RGPD4 Gene

mRNA/cDNA for RGPD4 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD4 Gene

RANBP2-like and GRIP domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD4 Gene

No ASD Table

Relevant External Links for RGPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD4 Gene

mRNA expression in normal human tissues for RGPD4 Gene

mRNA differential expression in normal tissues according to GTEx for RGPD4 Gene

This gene is overexpressed in Testis (x26.6).

Protein differential expression in normal tissues from HIPED for RGPD4 Gene

This gene is overexpressed in Brain (37.1) and Heart (31.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGPD4 Gene

SOURCE GeneReport for Unigene cluster for RGPD4 Gene Hs.449164

genes like me logo Genes that share expression patterns with RGPD4: view

Protein tissue co-expression partners for RGPD4 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RGPD4 Gene

Orthologs for RGPD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RANBP2 35
  • 85.26 (n)
  • 84.9 (a)
(Mus musculus)
Mammalia Ranbp2 35
  • 87.87 (n)
  • 88.67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 82 (a)
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
-- 36
  • 90 (a)
-- 36
  • 82 (a)
-- 36
  • 96 (a)
(Gallus gallus)
Aves RANBP2 35
  • 71.02 (n)
  • 68.77 (a)
-- 36
  • 44 (a)
-- 36
  • 60 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.69 (n)
  • 62.64 (a)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.71 (n)
  • 55.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 7 (a)
Y17G9B.4 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
Species with no ortholog for RGPD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD4 Gene

Gene Tree for RGPD4 (if available)
Gene Tree for RGPD4 (if available)

Paralogs for RGPD4 Gene

Paralogs for RGPD4 Gene

(8) SIMAP similar genes for RGPD4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGPD4: view

Variants for RGPD4 Gene

Sequence variations from dbSNP and Humsavar for RGPD4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs700862 -- 107,887,099(-) agaac(G/T)ggcat intron-variant, downstream-variant-500B
rs700863 -- 107,870,641(-) AAATA(C/T)CTTCT intron-variant
rs700869 -- 107,836,356(-) gtggg(C/T)ggatc intron-variant
rs831995 -- 107,836,730(-) TCAAA(G/T)AAGAA intron-variant
rs832002 -- 107,849,599(+) tctcc(A/T)gacct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD4 Gene

Variant ID Type Subtype PubMed ID
esv2720482 CNV Deletion 23290073
dgv61n68 CNV Gain 17160897
nsv829610 CNV Gain 20364138
nsv829611 CNV Gain 20364138
esv2475213 CNV Loss 19546169
esv27269 CNV Gain+Loss 19812545
esv995182 CNV Loss 20482838
esv1536919 CNV Deletion 17803354
esv1116837 CNV Insertion 17803354
esv2720498 CNV Deletion 23290073
dgv1233e1 CNV Complex 17122850
dgv1234e1 CNV Complex 17122850
dgv724e199 CNV Deletion 23128226

Variation tolerance for RGPD4 Gene

Gene Damage Index Score: 12.17; 93.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGPD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD4 Gene

Disorders for RGPD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RGPD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mesenchymal cell neoplasm
  • benign miscellaneous mesenchymal tumor
- elite association
Search RGPD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGPD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RGPD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGPD4 Gene

Publications for RGPD4 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 67
  2. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 67
  3. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  4. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PMID: 19596235) Svendsen J.M. … Harper J.W. (Cell 2009) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for RGPD4 Gene

Sources for RGPD4 Gene

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