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Aliases for RGPD4 Gene

Aliases for RGPD4 Gene

  • RANBP2-Like And GRIP Domain Containing 4 2 3 5
  • RGP4 3 4
  • RanBP2-Like And GRIP Domain-Containing Protein 4 3

External Ids for RGPD4 Gene

Previous GeneCards Identifiers for RGPD4 Gene

  • GC02U900817
  • GC02M087836
  • GC02P107810
  • GC02P109910
  • GC02P108443

Summaries for RGPD4 Gene

GeneCards Summary for RGPD4 Gene

RGPD4 (RANBP2-Like And GRIP Domain Containing 4) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is RGPD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD4 Gene

Genomics for RGPD4 Gene

Regulatory Elements for RGPD4 Gene

Enhancers for RGPD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F108597 0.4 ENCODE 10.2 +770.6 770628 0.2 HDGF ATF1 GLI4 FEZF1 ZNF2 GLIS2 GATA2 ZNF143 ZNF207 ZNF263 RPL10P5 RGPD4-AS1 LOC100128964 GACAT1 RGPD4 PIR40245 LIMS1
GH02F108313 0.8 Ensembl ENCODE 4.9 +488.8 488800 3.6 SOX13 BCOR KLF1 TFAP4 SAP130 TAL1 ARID4B ZMYM3 FEZF1 ZIC2 SULT1C2 LINC01594 RGPD4 PIR51121 SULT1C2P2
GH02F108532 0.2 ENCODE 4.5 +708.7 708666 5.9 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF143 SP3 SP5 GCC2 SULT1C4 RGPD4 LIMS1 PIR40245
GH02F108570 1.1 Ensembl ENCODE 4.1 +746.9 746939 7.5 HDGF TBP KLF1 ESRRA ARNT RELA ZNF121 POLR2A FOS MAFK GCC2 LINC01594 LIMS1-AS1 SULT1C4 RGPD4 LIMS1 PIR40245
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RGPD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGPD4 Gene

107,826,932 bp from pter
107,892,544 bp from pter
65,613 bases
Plus strand

Genomic View for RGPD4 Gene

Genes around RGPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD4 Gene

Proteins for RGPD4 Gene

  • Protein details for RGPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RanBP2-like and GRIP domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B9A029

    Protein attributes for RGPD4 Gene

    1758 amino acids
    Molecular mass:
    197289 Da
    Quaternary structure:
    No Data Available
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

    Alternative splice isoforms for RGPD4 Gene


neXtProt entry for RGPD4 Gene

Post-translational modifications for RGPD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGPD4 Gene

No data available for DME Specific Peptides for RGPD4 Gene

Domains & Families for RGPD4 Gene

Gene Families for RGPD4 Gene

Suggested Antigen Peptide Sequences for RGPD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRIP domain.
  • Contains 2 TPR repeats.
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with RGPD4: view

Function for RGPD4 Gene

Phenotypes for RGPD4 Gene

genes like me logo Genes that share phenotypes with RGPD4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGPD4 Gene

Localization for RGPD4 Gene

Subcellular locations from

Jensen Localization Image for RGPD4 Gene COMPARTMENTS Subcellular localization image for RGPD4 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RGPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGPD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGPD4 Gene

Pathways & Interactions for RGPD4 Gene

SuperPathways for RGPD4 Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD4: view

Pathways by source for RGPD4 Gene

1 KEGG pathway for RGPD4 Gene

Gene Ontology (GO) - Biological Process for RGPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport IEA --
genes like me logo Genes that share ontologies with RGPD4: view

No data available for SIGNOR curated interactions for RGPD4 Gene

Transcripts for RGPD4 Gene

mRNA/cDNA for RGPD4 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD4 Gene

RANBP2-like and GRIP domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD4 Gene

No ASD Table

Relevant External Links for RGPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGPD4 Gene

mRNA differential expression in normal tissues according to GTEx for RGPD4 Gene

This gene is overexpressed in Testis (x26.6).

Protein differential expression in normal tissues from HIPED for RGPD4 Gene

This gene is overexpressed in Brain (37.1) and Heart (31.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RGPD4 Gene

Protein tissue co-expression partners for RGPD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RGPD4 Gene:


SOURCE GeneReport for Unigene cluster for RGPD4 Gene:

genes like me logo Genes that share expression patterns with RGPD4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RGPD4 Gene

Orthologs for RGPD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
-- 35
  • 96 (a)
-- 35
  • 90 (a)
-- 35
  • 82 (a)
(Mus musculus)
Mammalia Ranbp2 34
  • 87.87 (n)
(Bos Taurus)
Mammalia RANBP2 34
  • 85.26 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
-- 35
  • 76 (a)
(Gallus gallus)
Aves RANBP2 34
  • 71.02 (n)
-- 35
  • 60 (a)
-- 35
  • 48 (a)
-- 35
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 34
  • 66.69 (n)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 34
  • 56.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 35
  • 14 (a)
(Caenorhabditis elegans)
Secernentea Y17G9B.4 35
  • 13 (a)
T22F3.12 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 4 (a)
Species where no ortholog for RGPD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD4 Gene

Gene Tree for RGPD4 (if available)
Gene Tree for RGPD4 (if available)

Paralogs for RGPD4 Gene

(8) SIMAP similar genes for RGPD4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGPD4: view

Variants for RGPD4 Gene

Sequence variations from dbSNP and Humsavar for RGPD4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10169113 -- 107,883,234(+) CACCC(A/C)TCTTC intron-variant
rs10192037 -- 107,858,470(+) GTCTC(A/G)CTCTG intron-variant
rs1043054 -- 107,861,673(+) TCTGA(C/G)AAAGA nc-transcript-variant, reference, missense
rs1047161 -- 107,888,361(+) TCAGG(G/T)GAACA intron-variant
rs1047165 -- 107,888,406(+) CAGTC(A/G)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD4 Gene

Variant ID Type Subtype PubMed ID
dgv4034n100 CNV gain 25217958
dgv61n68 CNV gain 17160897
dgv6988n54 CNV loss 21841781
dgv724e199 CNV deletion 23128226
esv1116837 CNV insertion 17803354
esv1536919 CNV deletion 17803354
esv2475213 CNV loss 19546169
esv2720482 CNV deletion 23290073
esv2720498 CNV deletion 23290073
esv27269 CNV gain+loss 19812545
esv2759081 CNV gain 17122850
esv3591913 CNV gain 21293372
esv995182 CNV loss 20482838
nsv1118872 CNV deletion 24896259
nsv1126558 CNV deletion 24896259
nsv582636 CNV loss 21841781
nsv829610 CNV gain 20364138
nsv829611 CNV gain 20364138
nsv953785 CNV deletion 24416366
nsv961849 CNV duplication 23825009
nsv961850 CNV duplication 23825009
nsv963681 CNV duplication 23825009

Variation tolerance for RGPD4 Gene

Gene Damage Index Score: 12.17; 93.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGPD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD4 Gene

Disorders for RGPD4 Gene

Relevant External Links for RGPD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGPD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD4 Gene

Publications for RGPD4 Gene

  1. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 3 4 64
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  4. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PMID: 19596235) Svendsen J.M. … Harper J.W. (Cell 2009) 3 64

Products for RGPD4 Gene

Sources for RGPD4 Gene

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