RGPD4 Gene
protein-coding GIFtS: 38
GCID: GC02P108443
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RANBP2-like and GRIP domain containing 4
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Aliases
for RGPD4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RANBP2-Like And GRIP Domain Containing 41 2 | | RGP41 2 3 5 | | DKFZp686P02881 | | RanBP2-Like And GRIP Domain-Containing Protein 42 |
Export aliases for RGPD4 gene to outside databasesPrevious GC identifers: GC02U900817 GC02M087836 GC02P107810 GC02P109910 |
Summaries
for RGPD4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RGPD4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RGPD4 gene promoter:
MEF-2A Sp1 MEF-2 IRF-1 Nkx2-5 aMEF-2 RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RGPD4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGPD4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q12.3 Ensembl cytogenetic band: 2q12.3 HGNC cytogenetic band: 2q12.3RGPD4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P108443: view genomic region
(about GC identifiers)
Start:
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108,443,388 bp from pter |
End:
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108,509,000 bp from pter |
Size:
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65,613 bases |
Orientation:
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plus strand |
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Proteins
for RGPD4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RGPD4_HUMAN, Q7Z3J3 (See
protein sequence)Recommended Name: RanBP2-like and GRIP domain-containing protein 4 Size: 1758 amino acids; 197289 Da
Miscellaneous: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere
Secondary accessions: B9A029Alternative splicing: 2 isoforms: Q7Z3J3-1 Q7Z3J3-2 Explore the universe of human proteins at neXtProt for RGPD4: NX_Q7Z3J3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z3J3
RGPD4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872394.2
ENSEMBL proteins: ENSP00000386810 ENSP00000347081
Human Recombinant Protein Products for RGPD4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
RGPD4 for ontologies About GeneDecksing
RGPD4 Antibody Products:
Assay Products for RGPD4: |
Protein
Domains /
Families
for RGPD4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RGPD4 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q7Z3J3ProtoNet protein and cluster: Q7Z3J3 UniProtKB/Swiss-Prot: RGPD4_HUMAN, Q7Z3J3Similarity: Contains 1 GRIP domainSimilarity: Contains 2 RanBD1 domainsSimilarity: Contains 2 TPR repeats |
Function
for RGPD4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
3 GenomeRNAi human phenotypes for RGPD4:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RGPD4 (NM_182588) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGPD4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD4 |
|
Pathways & Interactions
for RGPD4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGPD4
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/10 Interacting proteins for RGPD4 (Q7Z3J33 ENSP000003868104) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000042 | protein targeting to Golgi |
IEA | -- |
RGPD4 for ontologies About GeneDecksing
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Drugs & Compounds
for RGPD4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RGPD4
Search CenterWatch for drugs/clinical trials and news about RGPD4
|
Transcripts
for RGPD4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RGPD4 gene: NM_182588.2 Unigene Cluster for RGPD4: RANBP2-like and GRIP domain containing 4 Hs.449164 [show with all ESTs]Unigene Representative Sequence: BX5378612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000408999(uc010ywk.2 uc002tdu.3 uc010ywl.2) ENST00000354986
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RGPD4 (NM_182588) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGPD4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD4 |
Additional cDNA sequence: AK302921.1 BX537861.1 10 DOTS entries: DT.91842999 DT.120933586 DT.91900581 DT.92409447 DT.95274706 DT.120933571 DT.86858214 DT.120933560 DT.120996976 DT.87078957
GeneLoc Exon Structure
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Expression
for RGPD4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RGPD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RGPD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGPD4
SOURCE GeneReport for Unigene cluster: Hs.449164
SABiosciences Custom PCR Arrays for RGPD4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGPD4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RGPD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGPD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGPD4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD4 |
Orthologs
for RGPD4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RGPD4 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for RGPD4 (if available)
TreeFam Gene Tree for RGPD4 (if available) |
Paralogs
for RGPD4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RGPD4 gene
- RGPD31 2 RGPD11 2 RGPD21 2 RGPD81 2 RGPD51 2 RGPD61 2 RANBP22 RANBP12
8 SIMAP similar genes for RGPD4 using alignment to 2 protein entries: RGPD4_HUMAN (see all proteins):RGPD3 RGPD1 RGPD2 RGPD5 RGPD6 RGPD8
RANBP2 RANBP1
RGPD4 for paralogs About GeneDecksing
|
Genomic Variants
for RGPD4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RGPD4 (108443388 - 108509000 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for RGPD4
8 CNVs: 23576 3382 74192 78690 97932 89873 78691 78692 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGPD4 |
|
Disorders
/ Diseases
for RGPD4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RGPD4 for disorders About MalaCards
RGPD4 for disorders About GeneDecksing
OMIM gene information: 612707
OMIM disorders: --
Export disorders for RGPD4 gene to outside databases
|
Publications
for RGPD4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RGPD4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RGPD4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2, 3 Hillier L.W....Wilson R.K. (2005)
- Complex genomic rearrangements lead to novel primate gene function. (PubMed id 15710750)1, 2, 3 Ciccarelli F.D.... Bork P. (2005)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1 Svendsen J.M.... Harper J.W. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
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External Searches for RGPD4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RGPD4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RGPD4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RGPD4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RGPD4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RGPD4 gene:
Search GeneIP for patents involving RGPD4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RGPD4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RGPD4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGPD4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGPD4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RGPD4 | | OriGene 3'-UTR Clone for RGPD4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RGPD4 | | OriGene Custom Protein Services for RGPD4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGPD4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGPD4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGPD4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGPD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGPD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGPD4 |
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| | | | Search Tocris compounds for RGPD4 |
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 | | | RGPD4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RGPD4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD4 |
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