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Aliases for RGPD3 Gene

Aliases for RGPD3 Gene

  • RANBP2-Like And GRIP Domain Containing 3 2 3
  • RGP3 3 4 6
  • RanBP2-Like And GRIP Domain-Containing Protein 3 3

External Ids for RGPD3 Gene

Previous GeneCards Identifiers for RGPD3 Gene

  • GC00U921699
  • GC02U900831
  • GC02M107007

Summaries for RGPD3 Gene

Entrez Gene Summary for RGPD3 Gene

  • This gene is located in a cluster of Ran-binding protein related genes on chromosome 2 which arose through duplication in primates. The encoded protein contains an N-terminal TPR (tetratricopeptide repeat) domain, two Ran-binding domains, and a C-terminal GRIP domain (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain. [provided by RefSeq, Sep 2011]

GeneCards Summary for RGPD3 Gene

RGPD3 (RANBP2-Like And GRIP Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is PPIE.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD3 Gene

Genomics for RGPD3 Gene

Regulatory Elements for RGPD3 Gene

Genomic Location for RGPD3 Gene

106,391,290 bp from pter
106,468,376 bp from pter
77,087 bases
Minus strand

Genomic View for RGPD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD3 Gene

Proteins for RGPD3 Gene

  • Protein details for RGPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RanBP2-like and GRIP domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B8ZZM4

    Protein attributes for RGPD3 Gene

    1758 amino acids
    Molecular mass:
    197487 Da
    Quaternary structure:
    No Data Available
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere

neXtProt entry for RGPD3 Gene

Proteomics data for RGPD3 Gene at MOPED

Post-translational modifications for RGPD3 Gene

  • Ubiquitination at Lys106, Lys799, Lys1086, Lys1181, Lys1206, Lys1383, Lys1421, and Lys1449
  • Modification sites at PhosphoSitePlus

Other Protein References for RGPD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGPD3 Gene

Domains for RGPD3 Gene

Gene Families for RGPD3 Gene

Protein Domains for RGPD3 Gene

Suggested Antigen Peptide Sequences for RGPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRIP domain.
  • Contains 2 TPR repeats.
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with RGPD3: view

Function for RGPD3 Gene

Gene Ontology (GO) - Molecular Function for RGPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGPD3: view

Animal Model Products

CRISPR Products

miRNA for RGPD3 Gene

miRTarBase miRNAs that target RGPD3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGPD3 Gene

Localization for RGPD3 Gene

Subcellular locations from

Jensen Localization Image for RGPD3 Gene COMPARTMENTS Subcellular localization image for RGPD3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RGPD3 Gene

Pathways for RGPD3 Gene

SuperPathways for RGPD3 Gene

No Data Available

Interacting Proteins for RGPD3 Gene

Gene Ontology (GO) - Biological Process for RGPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD3: view

No data available for Pathways by source for RGPD3 Gene

Transcripts for RGPD3 Gene

mRNA/cDNA for RGPD3 Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD3 Gene

RANBP2-like and GRIP domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD3 Gene

No ASD Table

Relevant External Links for RGPD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD3 Gene

mRNA expression in normal human tissues for RGPD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGPD3 Gene

This gene is overexpressed in Testis (13.1).

Protein differential expression in normal tissues for RGPD3 Gene

This gene is overexpressed in Pancreas (23.2), Serum (14.8), Brain (14.1), and Heart (12.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGPD3 Gene

SOURCE GeneReport for Unigene cluster for RGPD3 Gene Hs.726367

genes like me logo Genes that share expressions with RGPD3: view

Expression partners for RGPD3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGPD3 Gene

Orthologs for RGPD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RANBP2 35
  • 85.32 (n)
  • 84.77 (a)
(Mus musculus)
Mammalia Ranbp2 35
  • 87.97 (n)
  • 88.42 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 82 (a)
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
-- 36
  • 90 (a)
-- 36
  • 81 (a)
-- 36
  • 96 (a)
(Gallus gallus)
Aves RANBP2 35
  • 71 (n)
  • 68.89 (a)
-- 36
  • 44 (a)
-- 36
  • 60 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.56 (n)
  • 62.52 (a)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.38 (n)
  • 54.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 7 (a)
Y17G9B.4 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
Species with no ortholog for RGPD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD3 Gene

Gene Tree for RGPD3 (if available)
Gene Tree for RGPD3 (if available)

Paralogs for RGPD3 Gene

Paralogs for RGPD3 Gene

(8) SIMAP similar genes for RGPD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGPD3: view

Variants for RGPD3 Gene

Sequence variations from dbSNP and Humsavar for RGPD3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs700866 -- 106,432,991(+) TTCTG(C/T)CCATC missense, reference
rs826530 -- 106,458,284(+) GAAAT(G/T)AGGCC intron-variant
rs832004 -- 106,445,530(-) tgctg(G/T)gatta intron-variant
rs832007 -- 106,444,823(-) TGATA(C/T)GTAGT intron-variant
rs832326 -- 106,400,696(+) ACAGG(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD3 Gene

Variant ID Type Subtype PubMed ID
nsv834322 CNV Gain 17160897
esv2720482 CNV Deletion 23290073
esv29426 CNV Gain+Loss 19812545
esv1179092 CNV Insertion 17803354

Relevant External Links for RGPD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD3 Gene

Disorders for RGPD3 Gene

No disorders were found for RGPD3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RGPD3 Gene

Publications for RGPD3 Gene

  1. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 3 4
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for RGPD3 Gene

Sources for RGPD3 Gene

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