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Aliases for RGPD2 Gene

Aliases for RGPD2 Gene

  • RANBP2-Like And GRIP Domain Containing 2 2 3
  • Ran-Binding Protein 2-Like 2 3 4
  • RanBP2-Like 2 3 4
  • RanBP2L2 3 4
  • RGP2 3 4
  • Ran Binding Protein 2-Like 2 3
  • Nucleoporin 3
  • NUP358 3

External Ids for RGPD2 Gene

Previous GeneCards Identifiers for RGPD2 Gene

  • GC02M087917
  • GC02P086988
  • GC02M088055

Summaries for RGPD2 Gene

GeneCards Summary for RGPD2 Gene

RGPD2 (RANBP2-Like And GRIP Domain Containing 2) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is PPIE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD2 Gene

Genomics for RGPD2 Gene

Regulatory Elements for RGPD2 Gene

Genomic Location for RGPD2 Gene

87,755,955 bp from pter
87,985,814 bp from pter
229,860 bases
Minus strand

Genomic View for RGPD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RGPD2 Gene

Proteins for RGPD2 Gene

  • Protein details for RGPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • P0C839
    • Q68DN6
    • Q6V1X0

    Protein attributes for RGPD2 Gene

    1756 amino acids
    Molecular mass:
    197308 Da
    Quaternary structure:
    No Data Available
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere
    • Sequence=AAQ63888.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for RGPD2 Gene

Proteomics data for RGPD2 Gene at MOPED

Post-translational modifications for RGPD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGPD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGPD2 Gene

Domains & Families for RGPD2 Gene

Gene Families for RGPD2 Gene

Protein Domains for RGPD2 Gene

Suggested Antigen Peptide Sequences for RGPD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRIP domain.
  • Contains 3 TPR repeats.
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with RGPD2: view

Function for RGPD2 Gene

Gene Ontology (GO) - Molecular Function for RGPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGPD2: view

Phenotypes for RGPD2 Gene

GenomeRNAi human phenotypes for RGPD2:
genes like me logo Genes that share phenotypes with RGPD2: view

Animal Model Products

CRISPR Products

miRNA for RGPD2 Gene

miRTarBase miRNAs that target RGPD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RGPD2 Gene

Localization for RGPD2 Gene

Subcellular locations from

Jensen Localization Image for RGPD2 Gene COMPARTMENTS Subcellular localization image for RGPD2 gene
Compartment Confidence
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RGPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGPD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGPD2 Gene

Pathways & Interactions for RGPD2 Gene

SuperPathways for RGPD2 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD2: view

Pathways by source for RGPD2 Gene

1 KEGG pathway for RGPD2 Gene

Interacting Proteins for RGPD2 Gene

Gene Ontology (GO) - Biological Process for RGPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD2: view

No data available for SIGNOR curated interactions for RGPD2 Gene

Drugs & Compounds for RGPD2 Gene

No Compound Related Data Available

Transcripts for RGPD2 Gene

mRNA/cDNA for RGPD2 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD2 Gene

RANBP2-like and GRIP domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD2 Gene

No ASD Table

Relevant External Links for RGPD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD2 Gene

mRNA expression in normal human tissues for RGPD2 Gene

mRNA differential expression in normal tissues according to GTEx for RGPD2 Gene

This gene is overexpressed in Cervix - Endocervix (x10.0) and Testis (x8.5).

Protein differential expression in normal tissues from HIPED for RGPD2 Gene

This gene is overexpressed in Serum (38.7) and Heart (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGPD2 Gene

SOURCE GeneReport for Unigene cluster for RGPD2 Gene Hs.652430

genes like me logo Genes that share expression patterns with RGPD2: view

Protein tissue co-expression partners for RGPD2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RGPD2 Gene

Orthologs for RGPD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RANBP2 35
  • 84.97 (n)
  • 83.72 (a)
(Mus musculus)
Mammalia Ranbp2 35
  • 87.81 (n)
  • 87.88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 79 (a)
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
(Gallus gallus)
Aves RANBP2 35
  • 71.08 (n)
  • 68.58 (a)
-- 36
  • 44 (a)
-- 36
  • 60 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.37 (n)
  • 62.26 (a)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.72 (n)
  • 55.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 7 (a)
Y17G9B.4 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
Species with no ortholog for RGPD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD2 Gene

Gene Tree for RGPD2 (if available)
Gene Tree for RGPD2 (if available)

Paralogs for RGPD2 Gene

Paralogs for RGPD2 Gene

(8) SIMAP similar genes for RGPD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGPD2: view

Variants for RGPD2 Gene

Sequence variations from dbSNP and Humsavar for RGPD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1017495 -- 87,973,982(+) ACTGA(C/T)CAGTT intron-variant
rs1017496 -- 87,974,014(+) CAGGG(C/T)CACTG intron-variant
rs1324814 -- 87,853,721(+) ATTTT(G/T)CTTTC intron-variant
rs1324815 -- 87,855,633(+) TGGGC(A/G)GGCAG intron-variant
rs1324833 -- 87,905,376(-) CTATC(A/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD2 Gene

Variant ID Type Subtype PubMed ID
esv25494 CNV Gain 19812545
nsv7316 OTHER Inversion 18451855
nsv874473 CNV Gain 21882294
dgv1214e1 CNV Complex 17122850
nsv874474 CNV Loss 21882294
nsv519198 CNV Loss 19592680
nsv874475 CNV Loss 21882294
esv33176 CNV Loss 17666407
dgv1215e1 CNV Complex 17122850
nsv2815 CNV Loss 18451855
nsv10064 CNV Gain 18304495
nsv498927 CNV Loss 21111241
nsv508849 CNV Insertion 20534489
nsv516958 CNV Gain+Loss 19592680
dgv61n16 CNV Deletion 17901297
nsv834287 CNV Gain 17160897
nsv834288 CNV Gain 17160897
nsv874574 CNV Gain 21882294
dgv4227n71 CNV Loss 21882294
nsv874577 CNV Gain 21882294
nsv10070 CNV Gain 18304495
nsv820913 CNV Deletion 20802225
esv27348 CNV Gain 19812545

Variation tolerance for RGPD2 Gene

Gene Damage Index Score: 2.81; 47.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGPD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD2 Gene

Disorders for RGPD2 Gene

Relevant External Links for RGPD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RGPD2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD2 Gene

Publications for RGPD2 Gene

  1. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 67
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PMID: 22488850) Zuo L. … Luo X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012) 67
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 67

Products for RGPD2 Gene

Sources for RGPD2 Gene

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