RGPD2 Gene
protein-coding GIFtS: 36
GCID: GC02M088055
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RANBP2-like and GRIP domain containing 2
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Aliases
for RGPD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RANBP2-Like And GRIP Domain Containing 21 2 | | NUP3582 | | RGP21 2 3 5 | | Nucleoporin1 | | RANBP2L21 2 3 | | Ran Binding Protein 2-Like 22 | | Ran-Binding Protein 2-Like 22 3 | | RANBP2-Like And GRIP Domain-Containing Protein 22 | | RanBP2-Like 22 3 | | RanBP2L23 |
Export aliases for RGPD2 gene to outside databasesPrevious GC identifers: GC02M087917 GC02P086988 GC02M087838 |
Summaries
for RGPD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RGPD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RGPD2 gene promoter:
ER-alpha Cdc5 RORalpha2 C/EBPalpha GATA-1 YY1 MEF-2A FOXO4 aMEF-2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for RGPD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGPD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2RGPD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M088055: view genomic region
(about GC identifiers)
Start:
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88,055,474 bp from pter |
End:
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88,285,309 bp from pter |
Size:
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229,836 bases |
Orientation:
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minus strand |
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Proteins
for RGPD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RGPD2_HUMAN, P0DJD1 (See
protein sequence)Recommended Name: RANBP2-like and GRIP domain-containing protein 2 Size: 1756 amino acids; 197308 Da
Miscellaneous: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere
Sequence caution: Sequence=AAQ63888.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: P0C839 Q68DN6 Q6V1X0Explore the universe of human proteins at neXtProt for RGPD2: NX_P0DJD1
RGPD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001071638.2
ENSEMBL proteins: ENSP00000381214 ENSP00000413275 ENSP00000332727
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
RGPD2 for ontologies About GeneDecksing
RGPD2 Antibody Products:
Assay Products for RGPD2: |
Protein
Domains /
Families
for RGPD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RGPD2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P0DJD1ProtoNet protein and cluster: P0DJD1 UniProtKB/Swiss-Prot: RGPD2_HUMAN, P0DJD1Similarity: Contains 1 GRIP domainSimilarity: Contains 2 RanBD1 domainsSimilarity: Contains 3 TPR repeats |
Function
for RGPD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RGPD2 (NM_001078170) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGPD2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD2 |
|
Pathways & Interactions
for RGPD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGPD2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000042 | protein targeting to Golgi |
IEA | -- |
RGPD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RGPD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RGPD2
Search CenterWatch for drugs/clinical trials and news about RGPD2
|
Transcripts
for RGPD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RGPD2 gene: NM_001078170.2 Unigene Cluster for RGPD2: RANBP2-like and GRIP domain containing 2 Hs.652430 [show with all ESTs]Unigene Representative Sequence: AK3003524 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398146(uc010fhc.2) ENST00000494592 ENST00000420840(uc002ssm.1 uc021vkn.1)
ENST00000327544
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RGPD2 (NM_001078170) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGPD2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD2 |
Additional cDNA sequence: AK298885.1 AK300276.1 AK300352.1 AY354203.1 11 DOTS entries: DT.95274717 DT.99940910 DT.121025771 DT.121025807 DT.87078349 DT.102839298 DT.120933560 DT.121024439 DT.121024440 DT.121024461 DT.121025823
GeneLoc Exon Structure
|
Expression
for RGPD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RGPD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTACTATG
About this image
See RGPD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGPD2
SOURCE GeneReport for Unigene cluster: Hs.652430
SABiosciences Custom PCR Arrays for RGPD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGPD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RGPD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGPD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGPD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD2 |
Orthologs
for RGPD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RGPD2 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for RGPD2 (if available)
TreeFam Gene Tree for RGPD2 (if available) |
Paralogs
for RGPD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RGPD2 gene
- RGPD11 2 RGPD41 2 RGPD31 2 RGPD81 2 RGPD51 2 RGPD61 2 RANBP22 RANBP12
8 SIMAP similar genes for RGPD2 using alignment to 2 protein entries: RGPD2_HUMAN (see all proteins):RGPD1 RGPD5 RGPD6 RGPD3 RGPD4 RGPD8
RANBP2 RANBP1
RGPD2 for paralogs About GeneDecksing
|
Genomic Variants
for RGPD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RGPD2 (88055474 - 88285309 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for RGPD2
15/17 CNVs (see all 17): 35864 89768 89761 89759 50583 3374 68073 7283 30964 78620 89767 4294 89760 30958 68079 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGPD2 |
|
Disorders
/ Diseases
for RGPD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RGPD2 for disorders About GeneDecksing
OMIM gene information: 612705
OMIM disorders: --
1  disease for RGPD2: About MalaCardsperiodontitis
Export disorders for RGPD2 gene to outside databases
|
Publications
for RGPD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RGPD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RGPD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2, 3 Hillier L.W....Wilson R.K. (2005)
- Complex genomic rearrangements lead to novel primate gene function. (PubMed id 15710750)1, 3 Ciccarelli F.D.... Bork P. (2005)
- Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)1 Zuo L....Luo X. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
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External Searches for RGPD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RGPD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RGPD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RGPD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RGPD2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RGPD2 gene:
Search GeneIP for patents involving RGPD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RGPD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RGPD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGPD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGPD2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RGPD2 | | OriGene 3'-UTR Clone for RGPD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | RGPD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for RGPD2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD2 |
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