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Aliases for RGPD2 Gene

Aliases for RGPD2 Gene

  • RANBP2-Like And GRIP Domain Containing 2 2 3
  • RGP2 3 4 6
  • Ran-Binding Protein 2-Like 2 3 4
  • RanBP2-Like 2 3 4
  • RanBP2L2 3 4
  • RANBP2-Like And GRIP Domain-Containing Protein 2 3
  • Ran Binding Protein 2-Like 2 3
  • Nucleoporin 3
  • NUP358 3

External Ids for RGPD2 Gene

Summaries for RGPD2 Gene

GeneCards Summary for RGPD2 Gene

RGPD2 (RANBP2-Like And GRIP Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is PPIE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD2 Gene

Genomics for RGPD2 Gene

Genomic Location for RGPD2 Gene

Start:
87,755,955 bp from pter
End:
87,825,952 bp from pter
Size:
69,998 bases
Orientation:
Minus strand

Genomic View for RGPD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD2 Gene

Regulatory Elements for RGPD2 Gene

Proteins for RGPD2 Gene

  • Protein details for RGPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJD1-RGPD2_HUMAN
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 2
    Protein Accession:
    P0DJD1
    Secondary Accessions:
    • P0C839
    • Q68DN6
    • Q6V1X0

    Protein attributes for RGPD2 Gene

    Size:
    1756 amino acids
    Molecular mass:
    197308 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere
    SequenceCaution:
    • Sequence=AAQ63888.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for RGPD2 Gene

Proteomics data for RGPD2 Gene at MOPED

Post-translational modifications for RGPD2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys105, Lys797, Lys1078, Lys1173, Lys1198, Lys1375, Lys1413, and Lys1441

Other Protein References for RGPD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGPD2 Gene

Domains for RGPD2 Gene

Gene Families for RGPD2 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for RGPD2 Gene

UniProtKB/Swiss-Prot:

RGPD2_HUMAN
Domain:
  • Contains 1 GRIP domain.:
    • P0DJD1
  • Contains 2 RanBD1 domains.:
    • P0DJD1
Similarity:
  • Contains 3 TPR repeats.:
    • P0DJD1
genes like me logo Genes that share domains with RGPD2: view

Function for RGPD2 Gene

Gene Ontology (GO) - Molecular Function for RGPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGPD2: view

miRNA for RGPD2 Gene

miRTarBase miRNAs that target RGPD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGPD2 Gene

Localization for RGPD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGPD2 Gene COMPARTMENTS Subcellular localization image for RGPD2 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for RGPD2 Gene

Pathways for RGPD2 Gene

SuperPathways for RGPD2 Gene

No Data Available

Interacting Proteins for RGPD2 Gene

Gene Ontology (GO) - Biological Process for RGPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD2: view

No data available for Pathways by source for RGPD2 Gene

Transcripts for RGPD2 Gene

mRNA/cDNA for RGPD2 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD2 Gene

RANBP2-like and GRIP domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD2 Gene

No ASD Table

Relevant External Links for RGPD2 Gene

GeneLoc Exon Structure for
RGPD2
ECgene alternative splicing isoforms for
RGPD2

Expression for RGPD2 Gene

mRNA expression in normal human tissues for RGPD2 Gene

mRNA differential expression in normal tissues according to GTEx for RGPD2 Gene

This gene is overexpressed in Cervix - Endocervix (10.0) and Testis (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGPD2 Gene

SOURCE GeneReport for Unigene cluster for RGPD2 Gene Hs.652430

genes like me logo Genes that share expressions with RGPD2: view

Orthologs for RGPD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RANBP2 36
  • 84.97 (n)
  • 83.72 (a)
mouse
(Mus musculus)
Mammalia Ranbp2 36
  • 87.81 (n)
  • 87.88 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 44 (a)
ManyToMany
-- 37
  • 60 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
RANBP2 36
  • 71.08 (n)
  • 68.58 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 42 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 36
  • 66.37 (n)
  • 62.26 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 36
  • 56.72 (n)
  • 55.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 37
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22F3.12 37
  • 7 (a)
ManyToMany
Y17G9B.4 37
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 4 (a)
OneToMany
Species with no ortholog for RGPD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD2 Gene

ENSEMBL:
Gene Tree for RGPD2 (if available)
TreeFam:
Gene Tree for RGPD2 (if available)

Paralogs for RGPD2 Gene

Paralogs for RGPD2 Gene

Selected SIMAP similar genes for RGPD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGPD2: view

Variants for RGPD2 Gene

Sequence variations from dbSNP and Humsavar for RGPD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2943825 -- 87,762,495(+) GAGAT(C/T)GTGCC intron-variant
rs2943834 -- 87,769,592(+) TGGAC(A/G)TTAGC intron-variant
rs2943835 -- 87,769,717(+) CAAAC(A/G)TTCTT intron-variant
rs2943874 -- 87,813,079(-) GTCAT(A/G)TGGTG intron-variant
rs4040444 -- 87,781,664(+) accac(A/G)ttggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD2 Gene

Variant ID Type Subtype PubMed ID
esv25494 CNV Gain 19812545
nsv7316 OTHER Inversion 18451855
nsv874473 CNV Gain 21882294
dgv1214e1 CNV Complex 17122850
nsv874474 CNV Loss 21882294
nsv519198 CNV Loss 19592680
nsv874475 CNV Loss 21882294
esv33176 CNV Loss 17666407
dgv1215e1 CNV Complex 17122850
nsv2815 CNV Loss 18451855
nsv10064 CNV Gain 18304495
nsv498927 CNV Loss 21111241
nsv508849 CNV Insertion 20534489
nsv516958 CNV Gain+Loss 19592680
dgv61n16 CNV Deletion 17901297
nsv834287 CNV Gain 17160897
nsv834288 CNV Gain 17160897
nsv874574 CNV Gain 21882294
dgv4227n71 CNV Loss 21882294
nsv874577 CNV Gain 21882294
nsv10070 CNV Gain 18304495
nsv820913 CNV Deletion 20802225
esv27348 CNV Gain 19812545

Relevant External Links for RGPD2 Gene

HapMap Linkage Disequilibrium report
RGPD2

Disorders for RGPD2 Gene

Relevant External Links for RGPD2

Genetic Association Database (GAD)
RGPD2
genes like me logo Genes that share disorders with RGPD2: view

No data available for UniProtKB/Swiss-Prot for RGPD2 Gene

Publications for RGPD2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 3 4
  2. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for RGPD2 Gene

Sources for RGPD2 Gene

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