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Aliases for RGP1 Gene

Aliases for RGP1 Gene

  • RGP1 Homolog, RAB6A GEF Complex Partner 1 2 3 5
  • KIAA0258 2 3 4
  • Retrograde Golgi Transport Protein RGP1 Homolog 3 4
  • RGP1 Retrograde Golgi Transport Homolog (S. Cerevisiae) 2
  • RGP1 Retrograde Golgi Transport Homolog 3

External Ids for RGP1 Gene

Previous HGNC Symbols for RGP1 Gene

  • KIAA0258

Summaries for RGP1 Gene

GeneCards Summary for RGP1 Gene

RGP1 (RGP1 Homolog, RAB6A GEF Complex Partner 1) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include Rab GTPase binding and Rab guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for RGP1 Gene

  • The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGP1 Gene

Genomics for RGP1 Gene

Regulatory Elements for RGP1 Gene

Enhancers for RGP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGP1 Gene

Chromosome:
9
Start:
35,749,280 bp from pter
End:
35,758,575 bp from pter
Size:
9,296 bases
Orientation:
Plus strand

Genomic View for RGP1 Gene

Genes around RGP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGP1 Gene

Proteins for RGP1 Gene

  • Protein details for RGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92546-RGP1_HUMAN
    Recommended name:
    RAB6A-GEF complex partner protein 2
    Protein Accession:
    Q92546
    Secondary Accessions:
    • Q5TCV5

    Protein attributes for RGP1 Gene

    Size:
    391 amino acids
    Molecular mass:
    42455 Da
    Quaternary structure:
    • Forms a complex with RIC1; the interaction enhances RAB6A GTPase activity. Interacts with RIC1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts with RAB33B.
    SequenceCaution:
    • Sequence=BAA13388.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RGP1 Gene

Proteomics data for RGP1 Gene at MOPED

Post-translational modifications for RGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGP1 Gene

Domains & Families for RGP1 Gene

Protein Domains for RGP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92546

UniProtKB/Swiss-Prot:

RGP1_HUMAN :
  • Belongs to the RGP1 family.
Family:
  • Belongs to the RGP1 family.
genes like me logo Genes that share domains with RGP1: view

No data available for Gene Families for RGP1 Gene

Function for RGP1 Gene

Molecular function for RGP1 Gene

UniProtKB/Swiss-Prot Function:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.

Gene Ontology (GO) - Molecular Function for RGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding IDA 23091056
genes like me logo Genes that share ontologies with RGP1: view
genes like me logo Genes that share phenotypes with RGP1: view

Animal Models for RGP1 Gene

MGI Knock Outs for RGP1:
  • Rgp1 tm1.1(KOMP)Vlcg

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGP1 Gene

Localization for RGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGP1 Gene

Cytoplasm, cytosol. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGP1 Gene COMPARTMENTS Subcellular localization image for RGP1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
mitochondrion 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA,TAS --
GO:0043234 protein complex IDA 23091056
genes like me logo Genes that share ontologies with RGP1: view

Pathways & Interactions for RGP1 Gene

genes like me logo Genes that share pathways with RGP1: view

Interacting Proteins for RGP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367318%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000367318 Q92546-RGP1_HUMAN for RGP1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for RGP1 Gene

None

No data available for SIGNOR curated interactions for RGP1 Gene

Drugs & Compounds for RGP1 Gene

No Compound Related Data Available

Transcripts for RGP1 Gene

mRNA/cDNA for RGP1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(133) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGP1 Gene

RGP1 retrograde golgi transport homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3:

Relevant External Links for RGP1 Gene

GeneLoc Exon Structure for
RGP1
ECgene alternative splicing isoforms for
RGP1

Expression for RGP1 Gene

mRNA expression in normal human tissues for RGP1 Gene

Protein differential expression in normal tissues from HIPED for RGP1 Gene

This gene is overexpressed in Heart (34.1), Placenta (21.3), and Liver (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RGP1 Gene



SOURCE GeneReport for Unigene cluster for RGP1 Gene Hs.493804

genes like me logo Genes that share expression patterns with RGP1: view

Protein tissue co-expression partners for RGP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGP1 Gene

Orthologs for RGP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGP1 35
  • 90.94 (n)
  • 97.83 (a)
RGP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGP1 35
  • 91.99 (n)
  • 98.21 (a)
RGP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgp1 35
  • 88.83 (n)
  • 96.93 (a)
Rgp1 16
Rgp1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGP1 35
  • 99.49 (n)
  • 100 (a)
RGP1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgp1 35
  • 89.86 (n)
  • 96.93 (a)
oppossum
(Monodelphis domestica)
Mammalia RGP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGP1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGP1 35
  • 70.89 (n)
  • 75.97 (a)
RGP1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17737 35
zebrafish
(Danio rerio)
Actinopterygii rgp1 35
  • 65.11 (n)
  • 66.84 (a)
rgp1 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10152 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003042 35
  • 49.14 (n)
  • 41.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1116 35
  • 48.5 (n)
  • 41.96 (a)
CG1116 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M01F1.9 35
  • 41.17 (n)
  • 32.66 (a)
M01F1.9 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2444 36
  • 43 (a)
OneToOne
Species with no ortholog for RGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGP1 Gene

ENSEMBL:
Gene Tree for RGP1 (if available)
TreeFam:
Gene Tree for RGP1 (if available)

Paralogs for RGP1 Gene

No data available for Paralogs for RGP1 Gene

Variants for RGP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGP1 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294

Variation tolerance for RGP1 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for RGP1 Gene

Disorders for RGP1 Gene

Relevant External Links for RGP1

Genetic Association Database (GAD)
RGP1
Human Genome Epidemiology (HuGE) Navigator
RGP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGP1

No disorders were found for RGP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGP1 Gene

Publications for RGP1 Gene

  1. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. (PMID: 23091056) Pusapati G.V. … Pfeffer S.R. (J. Biol. Chem. 2012) 2 3 4 67
  2. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. (PMID: 25342443) LindstrAPm S. … Tamimi R.M. (Nat Commun 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for RGP1 Gene

Sources for RGP1 Gene

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