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Aliases for RGP1 Gene

Aliases for RGP1 Gene

  • RGP1 Retrograde Golgi Transport Homolog (S. Cerevisiae) 2 3
  • KIAA0258 2 3 4
  • Retrograde Golgi Transport Protein RGP1 Homolog 3 4
  • RAB6A-GEF Complex Partner Protein 2 3

External Ids for RGP1 Gene

Previous HGNC Symbols for RGP1 Gene

  • KIAA0258

Summaries for RGP1 Gene

GeneCards Summary for RGP1 Gene

RGP1 (RGP1 Retrograde Golgi Transport Homolog (S. Cerevisiae)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RGP1 Gene

  • The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGP1 Gene

Genomics for RGP1 Gene

Genomic Location for RGP1 Gene

Start:
35,749,280 bp from pter
End:
35,790,428 bp from pter
Size:
41,149 bases
Orientation:
Plus strand

Genomic View for RGP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGP1 Gene

Proteins for RGP1 Gene

  • Protein details for RGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92546-RGP1_HUMAN
    Recommended name:
    RAB6A-GEF complex partner protein 2
    Protein Accession:
    Q92546
    Secondary Accessions:
    • Q5TCV5

    Protein attributes for RGP1 Gene

    Size:
    391 amino acids
    Molecular mass:
    42455 Da
    Quaternary structure:
    • Forms a complex with RIC1; the interaction enhances RAB6A GTPase activity. Interacts with RIC1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts with RAB33B.
    SequenceCaution:
    • Sequence=BAA13388.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RGP1 Gene

Proteomics data for RGP1 Gene at MOPED

Post-translational modifications for RGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGP1 Gene

Domains for RGP1 Gene

Protein Domains for RGP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92546

UniProtKB/Swiss-Prot:

RGP1_HUMAN :
  • Q92546
Family:
  • Belongs to the RGP1 family.
genes like me logo Genes that share domains with RGP1: view

No data available for Gene Families for RGP1 Gene

Function for RGP1 Gene

Molecular function for RGP1 Gene

UniProtKB/Swiss-Prot Function: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.

Gene Ontology (GO) - Molecular Function for RGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 23091056
GO:0017137 Rab GTPase binding IDA 23091056
genes like me logo Genes that share ontologies with RGP1: view

Phenotypes for RGP1 Gene

GenomeRNAi human phenotypes for RGP1:
genes like me logo Genes that share phenotypes with RGP1: view

miRNA for RGP1 Gene

miRTarBase miRNAs that target RGP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGP1 Gene

Localization for RGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGP1 Gene

Cytoplasm, cytosol. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGP1 Gene COMPARTMENTS Subcellular localization image for RGP1 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 23091056
GO:0016020 membrane IDA 23091056
GO:0034066 RIC1-RGP1 guanyl-nucleotide exchange factor complex IDA 23091056
GO:0043234 protein complex IDA 23091056
genes like me logo Genes that share ontologies with RGP1: view

Pathways for RGP1 Gene

SuperPathways for RGP1 Gene

No Data Available

Interacting Proteins for RGP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367318%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000367318 Q92546-RGP1_HUMAN for RGP1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for RGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042147 retrograde transport, endosome to Golgi IMP 23091056
GO:0043547 positive regulation of GTPase activity IDA 23091056
GO:1903363 negative regulation of cellular protein catabolic process IMP 23091056
genes like me logo Genes that share ontologies with RGP1: view

No data available for Pathways by source for RGP1 Gene

Transcripts for RGP1 Gene

mRNA/cDNA for RGP1 Gene

(133) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGP1 Gene

RGP1 retrograde golgi transport homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3:

Relevant External Links for RGP1 Gene

GeneLoc Exon Structure for
RGP1
ECgene alternative splicing isoforms for
RGP1

Expression for RGP1 Gene

mRNA expression in normal human tissues for RGP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGP1 Gene

SOURCE GeneReport for Unigene cluster for RGP1 Gene Hs.493804

genes like me logo Genes that share expressions with RGP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGP1 Gene

Orthologs for RGP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGP1 35
  • 99.49 (n)
  • 100 (a)
RGP1 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGP1 35
  • 90.94 (n)
  • 97.83 (a)
RGP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGP1 35
  • 91.99 (n)
  • 98.21 (a)
RGP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgp1 35
  • 88.83 (n)
  • 96.93 (a)
Rgp1 16
Rgp1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGP1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgp1 35
  • 89.86 (n)
  • 96.93 (a)
chicken
(Gallus gallus)
Aves RGP1 35
  • 70.89 (n)
  • 75.97 (a)
RGP1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17737 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10152 35
zebrafish
(Danio rerio)
Actinopterygii rgp1 35
  • 65.11 (n)
  • 66.84 (a)
rgp1 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003042 35
  • 49.14 (n)
  • 41.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1116 35
  • 48.5 (n)
  • 41.96 (a)
CG1116 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M01F1.9 35
  • 41.17 (n)
  • 32.66 (a)
M01F1.9 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2444 36
  • 43 (a)
OneToOne
Species with no ortholog for RGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGP1 Gene

ENSEMBL:
Gene Tree for RGP1 (if available)
TreeFam:
Gene Tree for RGP1 (if available)

Paralogs for RGP1 Gene

No data available for Paralogs for RGP1 Gene

Variants for RGP1 Gene

Sequence variations from dbSNP and Humsavar for RGP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1570249 -- 35,752,255(+) CCCAC(A/G)TCTAG intron-variant
rs1570250 -- 35,752,436(+) CTCTT(A/G)GGTTA intron-variant
rs7024615 -- 35,751,780(+) CTTAC(C/T)TGCTG intron-variant
rs11793927 -- 35,751,737(+) AAGGA(A/C)CCGTA reference, missense
rs35406278 -- 35,752,278(+) AACAG(-/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGP1 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294

Relevant External Links for RGP1 Gene

HapMap Linkage Disequilibrium report
RGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGP1 Gene

Disorders for RGP1 Gene

Relevant External Links for RGP1

Genetic Association Database (GAD)
RGP1
Human Genome Epidemiology (HuGE) Navigator
RGP1
genes like me logo Genes that share disorders with RGP1: view

No data available for UniProtKB/Swiss-Prot for RGP1 Gene

Publications for RGP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. (PMID: 23091056) Pusapati G.V. … Pfeffer S.R. (J. Biol. Chem. 2012) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3

Products for RGP1 Gene

Sources for RGP1 Gene

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