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Aliases for RGN Gene

Aliases for RGN Gene

  • Regucalcin 2 3
  • Gluconolactonase 2 3 4
  • SMP30 3 4 6
  • Senescence Marker Protein 30 3 4
  • GNL 3 4
  • RC 3 4
  • Regucalcin (Senescence Marker Protein-30) 2
  • Epididymis Secretory Protein Li 41 3
  • Senescence Marker Protein-30 2
  • EC 3.1.1.17 4
  • HEL-S-41 3
  • SMP-30 4

External Ids for RGN Gene

Summaries for RGN Gene

Entrez Gene Summary for RGN Gene

  • The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for RGN Gene

RGN (Regucalcin) is a Protein Coding gene. Diseases associated with RGN include scurvy and hepatocellular carcinoma. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include calcium ion binding and gluconolactonase activity.

UniProtKB/Swiss-Prot for RGN Gene

  • Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

Gene Wiki entry for RGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGN Gene

Genomics for RGN Gene

Genomic Location for RGN Gene

Start:
47,078,355 bp from pter
End:
47,093,314 bp from pter
Size:
14,960 bases
Orientation:
Plus strand

Genomic View for RGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGN Gene

Regulatory Elements for RGN Gene

Proteins for RGN Gene

  • Protein details for RGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15493-RGN_HUMAN
    Recommended name:
    Regucalcin
    Protein Accession:
    Q15493
    Secondary Accessions:
    • A4FTW1
    • A8K271
    • Q53FC9
    • Q5JRR5

    Protein attributes for RGN Gene

    Size:
    299 amino acids
    Molecular mass:
    33253 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for RGN Gene

    Alternative splice isoforms for RGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGN Gene

Proteomics data for RGN Gene at MOPED

Post-translational modifications for RGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGN Gene

No data available for DME Specific Peptides for RGN Gene

Domains for RGN Gene

UniProtKB/Swiss-Prot:

RGN_HUMAN
Family:
  • Belongs to the SMP-30/CGR1 family.:
    • Q15493
genes like me logo Genes that share domains with RGN: view

No data available for Gene Families for RGN Gene

Function for RGN Gene

Molecular function for RGN Gene

GENATLAS Biochemistry: rat calcium binding protein (regucalcin) homolog
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.7 mM for gluconolactone (with Zn(2+) as cofactor) {ECO:0000269 PubMed:20329768}; KM=0.6 mM for gluconolactone (with Mn(2+) as cofactor) {ECO:0000269 PubMed:20329768}; KM=1.3 mM for gluconolactone (with Mg(2+) as cofactor) {ECO:0000269 PubMed:20329768}; KM=3.7 mM for gluconolactone (with Ca(2+) as cofactor) {ECO:0000269 PubMed:20329768};
UniProtKB/Swiss-Prot CatalyticActivity: D-glucono-1,5-lactone + H(2)O = D-gluconate.
UniProtKB/Swiss-Prot Function: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

Enzyme Numbers (IUBMB) for RGN Gene

Gene Ontology (GO) - Molecular Function for RGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004341 gluconolactonase activity IDA 20329768
GO:0005509 calcium ion binding ISS --
GO:0008270 zinc ion binding IDA 20329768
GO:0030234 enzyme regulator activity IEA --
genes like me logo Genes that share ontologies with RGN: view
genes like me logo Genes that share phenotypes with RGN: view

Animal Models for RGN Gene

MGI Knock Outs for RGN:

miRNA for RGN Gene

miRTarBase miRNAs that target RGN

No data available for Transcription Factor Targeting and HOMER Transcription for RGN Gene

Localization for RGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGN Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGN Gene COMPARTMENTS Subcellular localization image for RGN gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with RGN: view

Pathways for RGN Gene

genes like me logo Genes that share pathways with RGN: view

Gene Ontology (GO) - Biological Process for RGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis ISS --
GO:0019853 L-ascorbic acid biosynthetic process IEA --
GO:0032781 positive regulation of ATPase activity ISS --
GO:0050848 regulation of calcium-mediated signaling ISS --
genes like me logo Genes that share ontologies with RGN: view

Compounds for RGN Gene

(1) HMDB Compounds for RGN Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(7) Novoseek inferred chemical compound relationships for RGN Gene

Compound -log(P) Hits PubMed IDs
tabun 69.8 1
sarin 58 1
soman 55.4 1
deoxyribonucleic acid 36.9 1
ascorbic acid 28.2 2
genes like me logo Genes that share compounds with RGN: view

Transcripts for RGN Gene

Unigene Clusters for RGN Gene

Regucalcin (senescence marker protein-30):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for RGN Gene

GeneLoc Exon Structure for
RGN
ECgene alternative splicing isoforms for
RGN

Expression for RGN Gene

mRNA expression in normal human tissues for RGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGN Gene

This gene is overexpressed in Adrenal Gland (10.0) and Liver (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGN Gene

SOURCE GeneReport for Unigene cluster for RGN Gene Hs.77854

genes like me logo Genes that share expressions with RGN: view

Orthologs for RGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGN 36
  • 88.99 (n)
  • 84.35 (a)
RGN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGN 36
  • 91.19 (n)
  • 91.3 (a)
RGN 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGN 36
  • 89.63 (n)
  • 91.3 (a)
RGN 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgn 36
  • 86.51 (n)
  • 88.63 (a)
Rgn 16
Rgn 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGN 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGN 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgn 36
  • 86.85 (n)
  • 88.63 (a)
chicken
(Gallus gallus)
Aves RGN 36
  • 73.47 (n)
  • 77.93 (a)
RGN 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGN 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rgn-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rgn 36
  • 69.23 (n)
  • 70.23 (a)
Str.11947 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9879 36
zebrafish
(Danio rerio)
Actinopterygii Dr.27166 36
rgn 36
  • 65.08 (n)
  • 64.07 (a)
rgn 37
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta regucalcin 36
  • 48.68 (n)
  • 38.13 (a)
regucalcin 37
  • 31 (a)
OneToMany
smp-30 37
  • 33 (a)
OneToMany
regucalcin 38
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL098W 36
  • 39.23 (n)
  • 28.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 39
YBR053C 36
  • 40.95 (n)
  • 30.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04301g 36
  • 41.91 (n)
  • 27.18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00326 36
  • 44.24 (n)
  • 29.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToOne
Species with no ortholog for RGN:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGN Gene

ENSEMBL:
Gene Tree for RGN (if available)
TreeFam:
Gene Tree for RGN (if available)

Paralogs for RGN Gene

No data available for Paralogs for RGN Gene

Variants for RGN Gene

Sequence variations from dbSNP and Humsavar for RGN Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14312 -- 47,092,999(+) GAATT(C/T)TGGGC utr-variant-3-prime
rs1131058 -- 47,078,708(+) CGCAC(A/T)GATCT utr-variant-5-prime
rs3814904 -- 47,078,249(+) GGGAC(G/T)GGGAC upstream-variant-2KB
rs3814905 -- 47,078,300(+) GCCGG(A/G)TCCCG upstream-variant-2KB
rs4480242 -- 47,092,820(+) TTACT(A/G)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGN Gene

Variant ID Type Subtype PubMed ID
nsv508767 CNV Insertion 20534489
nsv513604 CNV Insertion 21212237
esv1734378 CNV Insertion 17803354

Relevant External Links for RGN Gene

HapMap Linkage Disequilibrium report
RGN

Disorders for RGN Gene

(1) University of Copenhagen DISEASES for RGN Gene

(5) Novoseek inferred disease relationships for RGN Gene

Disease -log(P) Hits PubMed IDs
hepatitis 19.8 1
hepatocellular carcinoma 14.3 2
necrosis 0 1
tumors 0 4
cancer 0 1
genes like me logo Genes that share disorders with RGN: view

No data available for UniProtKB/Swiss-Prot for RGN Gene

Publications for RGN Gene

  1. Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. (PMID: 7548213) Fujita T. … Maruyama N. (Biochim. Biophys. Acta 1995) 2 3 4 23
  2. Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. (PMID: 10677570) Misawa H. … Yamaguchi M. (Int. J. Mol. Med. 2000) 3 4 23
  3. Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions. (PMID: 20329768) Chakraborti S. … Bahnson B.J. (Biochemistry 2010) 3 4 23
  4. Novel protein RGPR-p117: its role as the regucalcin gene transcription factor. (PMID: 19214710) Yamaguchi M. (Mol. Cell. Biochem. 2009) 3 23
  5. Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones. (PMID: 19347872) Maia C. … Socorro S. (J. Cell. Biochem. 2009) 3 23

Products for RGN Gene

Sources for RGN Gene

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