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RGN Gene

protein-coding   GIFtS: 61
GCID: GC0XP046937

Regucalcin

(Previous name: regucalcin (senescence marker protein-30))
  See RGN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
regucalcin1 2     Senescence Marker Protein-301
SMP302 3 5     HEL-S-412
gluconolactonase1 2     Epididymis Secretory Protein Li 412
Senescence Marker Protein 302 3     EC 3.1.1.173
GNL2 3     Gluconolactonase3
RC2 3     SMP-303
Regucalcin (Senescence Marker Protein-30)1     

External Ids:    HGNC: 99891   Entrez Gene: 91042   Ensembl: ENSG000001309887   OMIM: 3002125   UniProtKB: Q154933   

Export aliases for RGN gene to outside databases

Previous GC identifers: GC0XP045740 GC0XP045198 GC0XP045983 GC0XP046695 GC0XP046822 GC0XP044651


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGN Gene:
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed
in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this
protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene
cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Sep 2013)

GeneCards Summary for RGN Gene:
RGN (regucalcin) is a protein-coding gene. Diseases associated with RGN include scurvy. GO annotations related to this gene include gluconolactonase activity and calcium ion binding.

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493
Function: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and
galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro).
Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme
activities (By similarity)

Gene Wiki entry for RGN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGN gene promoter:
         NRSF form 1   FOXD3   NRSF form 2   AREB6   HSF2   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGN promoter sequence
   Search Chromatin IP Primers for RGN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3

RGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGN gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP046937:  view genomic region     (about GC identifiers)

Start:
46,937,775 bp from pter      End:
46,952,712 bp from pter
Size:
14,938 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493 (See protein sequence)
Recommended Name: Regucalcin  
Size: 299 amino acids; 33253 Da
Cofactor: Binds 1 divalent metal cation per subunit. Most active with zinc and manganese ions. The physiological
cofactor is most likely calcium or magnesium
Subunit: Monomer
Caution: Gluconolactonase catalyzes a key step in ascorbic acid (vitamin C) biosynthesis, but primates lack the
last enzyme in the pathway and are unable to synthesize vitamin C
4 PDB 3D structures from and Proteopedia for RGN:
3G4E (3D)        3G4H (3D)        4GNB (3D)        4GNC (3D)    
Secondary accessions: A4FTW1 A8K271 Q53FC9 Q5JRR5
Alternative splicing: 2 isoforms:  Q15493-1   Q15493-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGN: NX_Q15493

Explore proteomics data for RGN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269777.1  NP_001269778.1  NP_004674.1  NP_690608.1  

    ENSEMBL proteins: 
     ENSP00000253303   ENSP00000338400   ENSP00000380365   ENSP00000406568  

    RGN Human Recombinant Protein Products:

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    Novus Biologicals RGN Proteins
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    Cloud-Clone Corp. Proteins for RGN

     
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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for RGN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005511 SMP-30
     IPR008367 Regucalcin
     IPR011042 6-blade_b-propeller_TolB-like
     IPR013658 SGL

    Graphical View of Domain Structure for InterPro Entry Q15493

    ProtoNet protein and cluster: Q15493

    3 Blocks protein domains:
    IPB005511 Senescence marker protein-30 (SMP-30)
    IPB008367 Regucalcin signature
    IPB013658 SMP-30/Gluconolaconase/LRE-like region


    UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493
    Similarity: Belongs to the SMP-30/CGR1 family


    Find genes that share domains with RGN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGN_HUMAN, Q15493
    Function: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and
    galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro).
    Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme
    activities (By similarity)
    Catalytic activity: D-glucono-1,5-lactone + H(2)O = D-gluconate
    Biophysicochemical properties: Kinetic parameters: KM=2.7 mM for gluconolactone (with Zn(2+) as cofactor); KM=0.6
    mM for gluconolactone (with Mn(2+) as cofactor); KM=1.3 mM for gluconolactone (with Mg(2+) as cofactor); KM=3.7
    mM for gluconolactone (with Ca(2+) as cofactor);

         Genatlas biochemistry entry for RGN:
    rat calcium binding protein (regucalcin) homolog

         Enzyme Number (IUBMB): EC 3.1.1.171

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004341gluconolactonase activity IDA--
    GO:0005509calcium ion binding ISS--
    GO:0008270zinc ion binding IDA--
    GO:0030234enzyme regulator activity IEA--
         
    Find genes that share ontologies with RGN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RGN:
     Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgn):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  integument  liver/biliary system  mortality/aging 
     nervous system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with RGN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgntm1Aish for RGN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGN

    miRNA
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    miRTarBase miRNAs that target RGN:
    hsa-mir-1 (MIRT023777)

    Block miRNA regulation of human, mouse, rat RGN using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RGN:
    hsa-miR-485-5p hsa-miR-708* hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidRGN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RGN

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGN_HUMAN, Q15493: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    extracellular2
    plasma membrane2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with RGN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGN About    
    See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Ascorbate and aldarate metabolism0.61
    2Carbon metabolism
    Carbon metabolism0.38
    3Metabolism
    Metabolic pathways0.38
    4Pentose phosphate pathway (KEGG)
    Pentose phosphate pathway
    5Degradation of aromatic compounds
    Degradation of aromatic compounds


    Find genes that share SuperPaths with RGN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Kegg Pathways  (Kegg details for RGN):
        Pentose phosphate pathway
    Ascorbate and aldarate metabolism
    Metabolic pathways
    Carbon metabolism
    Degradation of aromatic compounds

        Pathway & Disease-focused RT2 Profiler PCR Array including RGN: 
              Nephrotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGN (Q154933 ENSP000002533034) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1D2Q149953I2D: score=2 
    THRAP108273I2D: score=2 
    DLG5ENSP000003614674STRING: ENSP00000361467
    PDCL3ENSP000002642544STRING: ENSP00000264254
    SLBPENSP000004176864STRING: ENSP00000417686
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis ISS--
    GO:0019853L-ascorbic acid biosynthetic process IEA--
    GO:0032781positive regulation of ATPase activity ISS--
    GO:0050848regulation of calcium-mediated signaling ISS--

    Find genes that share ontologies with RGN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGN

    1 HMDB Compound for RGN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 Novoseek inferred chemical compound relationships for RGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tabun 69.8 1 15247044 (1)
    sarin 58 1 15247044 (1)
    soman 55.4 1 15247044 (1)
    deoxyribonucleic acid 36.9 2 15702226 (1)
    ascorbic acid 28.2 9 17222174 (1), 19801822 (1)
    calcium 27.7 33 18704329 (5), 9753637 (4), 10360682 (3), 8765750 (1) (see all 9)
    superoxide 18.5 2 15902099 (1), 17569552 (1)



    Find genes that share compounds with RGN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGN gene (4 alternative transcripts): 
    NM_001282848.1  NM_001282849.1  NM_004683.5  NM_152869.3  

    Unigene Cluster for RGN:

    Regucalcin (senescence marker protein-30)
    Hs.77854  [show with all ESTs]
    Unigene Representative Sequence: NM_152869
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352078 ENST00000469346 ENST00000336169 ENST00000475448 ENST00000397180(uc004dgz.1 uc004dha.1 uc010nho.1)
    ENST00000457380(uc010nhp.1)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate RGN:
    hsa-miR-485-5p hsa-miR-708* hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidRGN 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RGN
      QuantiFast Probe-based Assays in human, mouse, rat RGN

    Additional mRNA sequence: 

    AB028125.1 AB032064.1 AK223360.1 AK290136.1 BC050371.1 BC058880.1 BC073173.1 D31815.1 

    6 DOTS entries:

    DT.100748481  DT.101980961  DT.99998879  DT.91742681  DT.99989586  DT.99999502 

    Selected AceView cDNA sequences (see all 66):

    NM_004683 BC073173 CB161948 BM984993 D31815 CD106286 BC050371 NM_152869 
    AA349125 BC058880 AW772220 CB164366 AW512880 AI354934 BE048889 AB032064 
    BE463707 AI804699 AI628356 BQ879062 BU949763 BI517593 BQ005205 BM924323 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RGN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -     -     -                 -                           
    SP2:                                                  -                           
    SP3:                    -     -     -                 -     -                     
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for RGN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTTTGGA
    RGN Expression
    About this image


    RGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Adrenal Gland (Endocrine System)
     
     Kidney (Urinary System)
    RGN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77854
        Pathway & Disease-focused RT2 Profiler PCR Array including RGN: 
              Nephrotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RGN gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgn1 , 5 regucalcin1, 5 86.51(n)1
    88.63(a)1
      X (16.04 cM)5
    197331  NM_009060.21  NP_033086.11 
     205497875 
    chicken
    (Gallus gallus)
    Aves RGN1 regucalcin 73.47(n)
    77.93(a)
      395480  NM_204729.1  NP_990060.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGN6
    regucalcin
    71(a)
    1 ↔ 1
    3(112098541-112108045)
    African clawed frog
    (Xenopus laevis)
    Amphibia rgn-A2 regucalcin (senescence marker protein-30) 74.44(n)    AB033368.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271662 Danio rerio clone RK049A3F10 regucalcin mRNA, complete more 76.79(n)    AY394949.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta regucalcin1 , 3 calcium ion binding3
    regucalcin1
    34(a)3
    48.68(n)1
    38.13(a)1
      11A13
    321651  NM_167316.11  NP_727588.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YBR053C)4
    YBR053C1
    Putative protein of unknown function; induced by cell more4
    YBR053C1
    40.95(n)1
    30.29(a)1
      2(340751-339675)4
    8523421, 4  NP_009609.11, 4 


    ENSEMBL Gene Tree for RGN (if available)
    TreeFam Gene Tree for RGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGN (see all 350)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842399331,2
    --46935788(+) GTTTTG/TTTTTT 2 -- us2k10--------
    rs1381884181,2
    C--46935852(+) TATCAC/TGGCTC 2 -- us2k10--------
    rs1896415791,2
    --46935886(+) TCAAGC/TGATGT 2 -- us2k10--------
    rs1811139751,2
    --46935934(+) ACCACA/GCCTGG 2 -- us2k10--------
    rs1859563031,2
    --46935935(+) CCACGC/TCTGGC 2 -- us2k10--------
    rs344319601,2
    C,F--46936098(+) AACCTC/TTATGT 2 -- us2k11Minor allele frequency- T:0.50NA 4
    rs1442209591,2
    --46936492(+) GGCCTA/GTATCC 2 -- us2k10--------
    rs732019721,2
    C,F--46936663(+) CTGGAT/CTCAAG 2 -- us2k12Minor allele frequency- C:0.00NA 3
    rs1910103751,2
    --46936724(+) ACCACA/GCCCAG 2 -- us2k10--------
    rs1433046411,2
    C--46936762(+) TTTCAC/TTCTTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGN (46937775 - 46952712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RGN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513604CNV Insertion21212237
    nsv508767CNV Insertion20534489
    esv1734378CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGN
    DNA2.0 Custom Variant and Variant Library Synthesis for RGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300212    OMIM disorders: --

    1 disease for RGN:    
    About MalaCards
    scurvy

    1 disease from the University of Copenhagen DISEASES database for RGN:
    Scurvy

    Find genes that share disorders with RGN           About GenesLikeMe

    5 Novoseek inferred disease relationships for RGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis 19.8 1 9059996 (1)
    hepatocellular carcinoma 14.3 2 15358188 (1), 19801822 (1)
    necrosis 0 1 15358188 (1)
    tumors 0 4 19347872 (2), 16136218 (1), 15358188 (1)
    cancer 0 1 19347872 (1)


    Export disorders for RGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGN gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with RGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. (PubMed id 7548213)1, 2, 3, 9 Fujita T....Maruyama N. (Biochim. Biophys. Acta 1995)
    2. Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions. (PubMed id 20329768)1, 2, 9 Chakraborti S. and Bahnson B.J. (Biochemistry 2010)
    3. Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. (PubMed id 10677570)1, 2, 9 Misawa H. and Yamaguchi M. (Int. J. Mol. Med. 2000)
    4. Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase. (PubMed id 23349732)1, 2 Aizawa S.... Senda T. (PLoS ONE 2013)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Senescence marker protein-30 (SMP30): structure and biological function. (PubMed id 9920722)1, 9 Fujita T. (Biochem. Biophys. Res. Commun. 1999)
    8. Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. (PubMed id 10360682)1, 9 Fujita T....Maruyama N. (Mech. Ageing Dev. 1999)
    9. Senescence marker protein-30 (SMP30) rescues cell death by enhancing plasma membrane Ca(2+)-pumping activity in Hep G2 cells. (PubMed id 9753637)1, 9 Fujita T....Maruyama N. (Biochem. Biophys. Res. Commun. 1998)
    10. Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. (PubMed id 15358188)1, 9 Matsuyama S....Sato N. (Biochem. Biophys. Res. Commun. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9104 HGNC: 9989 AceView: RGN Ensembl:ENSG00000130988 euGenes: HUgn9104
    ECgene: RGN Kegg: 9104 H-InvDB: RGN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGN gene:
    Search GeneIP for patents involving RGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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