RGN Gene
protein-coding GIFtS: 59
GCID: GC0XP046937
|
|
regucalcin (senescence marker protein-30)
| |
Aliases
for RGN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regucalcin (Senescence Marker Protein-30)1 2 | | Gluconolactonase3 | | SMP301 2 3 5 | | Regucalcin1 | | RC1 2 3 | | Senescence Marker Protein-302 | | Senescence Marker Protein 302 3 | | EC 3.1.1.173 | | GNL2 3 | | Gluconolactonase3 | | SMP-302 3 | | |
Export aliases for RGN gene to outside databasesPrevious GC identifers: GC0XP045740 GC0XP045198 GC0XP045983 GC0XP046695 GC0XP046822 GC0XP044651 |
Summaries
for RGN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RGN:
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed inthe liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this proteinmay also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster onchromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, butencoding the same protein. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493Function: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone andgalactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-bindingprotein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)
Gene Wiki entry for RGN
|
Genomic Views
for RGN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RGN gene promoter:
NRSF form 1 FOXD3 NRSF form 2 AREB6 HSF2 FOXO1a GR-alpha FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RGN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.3 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.3RGN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP046937: view genomic region
(about GC identifiers)
Start:
|
46,937,775 bp from pter |
End:
|
46,952,712 bp from pter |
Size:
|
14,938 bases |
Orientation:
|
plus strand |
|
Proteins
for RGN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493 (See
protein sequence)Recommended Name: Regucalcin Size: 299 amino acids; 33253 Da
Cofactor: Binds 1 divalent metal cation per subunit. Most active with zinc and manganese ions. The physiologicalcofactor is most likely calcium or magnesium
Subcellular location: Cytoplasm (By similarity)
Caution: Gluconolactonase catalyzes a key step in ascorbic acid (vitamin C) biosynthesis, but primates lack the lastenzyme in the pathway and are unable to synthesize vitamin C
2 PDB 3D structures from  and Proteopedia  for RGN:3G4E (3D)
3G4H (3D)
Secondary accessions: A4FTW1 A8K271 Q53FC9 Q5JRR5Alternative splicing: 2 isoforms: Q15493-1 Q15493-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RGN: NX_Q15493
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15493
RGN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004674.1 NP_690608.1
ENSEMBL proteins: ENSP00000253303 ENSP00000338400 ENSP00000380365 ENSP00000406568
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RGN for ontologies About GeneDecksing
RGN Antibody Products:
Assay Products for RGN: |
Protein
Domains /
Families
for RGN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RGN for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15493ProtoNet protein and cluster: Q15493 3 Blocks protein families: IPB005511 Senescence marker protein-30 (SMP-30) IPB008367 Regucalcin signature IPB013658 SMP-30/Gluconolaconase/LRE-like region
UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493Similarity: Belongs to the SMP-30/CGR1 family |
Function
for RGN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493Function: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone andgalactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-bindingprotein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)Catalytic activity: D-glucono-1,5-lactone + H(2)O = D-gluconateBiophysicochemical properties: Kinetic parameters: KM=2.7 mM for gluconolactone (with Zn(2+) as cofactor); KM=0.6 mMfor gluconolactone (with Mn(2+) as cofactor); KM=1.3 mM for gluconolactone (with Mg(2+) as cofactor); KM=3.7 mM forgluconolactone (with Ca(2+) as cofactor); Genatlas biochemistry entry for RGN:rat calcium binding protein (regucalcin) homolog
Enzyme Number (IUBMB): EC 3.1.1.171
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RGN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RGN for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RGN:
Animal Models:
Mouse knock-out Rgntm1Aish for RGN
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rgn):
RGN for phenotypes About GeneDecksing
|
Pathways & Interactions
for RGN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pentose phosphate pathway | | | 2 | Pentose and glucuronate interconversions | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Kegg Pathways (Kegg details for RGN):
RGN for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGN
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for RGN (Q154933 ENSP000002533034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006874 | cellular calcium ion homeostasis |
ISS | -- | | GO:0032781 | positive regulation of ATPase activity |
ISS | -- | | GO:0050848 | regulation of calcium-mediated signaling |
ISS | -- |
RGN for ontologies About GeneDecksing
|
Drugs & Compounds
for RGN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RGN for compounds About GeneDecksing
 Browse Tocris compounds for RGN
1 HMDB Compound for RGN About this table
7 Novoseek chemical compound relationships for RGN gene About this table
Search CenterWatch for drugs/clinical trials and news about RGN
|
Transcripts
for RGN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RGN gene (2 alternative transcripts): NM_004683.4 NM_152869.2 Unigene Cluster for RGN: Regucalcin (senescence marker protein-30) Hs.77854 [show with all ESTs]Unigene Representative Sequence: NM_1528696 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000352078 ENST00000469346 ENST00000336169 ENST00000475448 ENST00000397180(uc004dgz.1 uc004dha.1 uc010nho.1)
ENST00000457380(uc010nhp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RGN (NM_001126181) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGN |
Additional cDNA sequence: AB028125.1 AB032064.1 AK223360.1 AK290136.1 BC050371.1 BC058880.1 BC073173.1 D31815.1 6 DOTS entries: DT.100748481 DT.101980961 DT.99998879 DT.91742681 DT.99989586 DT.99999502 24/66 AceView cDNA sequences (see all 66): BM984993 BC073173 NM_004683 D31815 CB161948 NM_152869 CD106286 BC058880 BC050371 AA349125 BQ879062 BM924323 AW772220 BU949763 BF590441 BQ005205 BE348729 AB032064 AW772019 AV704357 BE048889 H49432 BF939573 AI804678
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RGN About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RGN
|
Expression
for RGN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RGN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTTTGGA
About this image
See RGN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGN
SOURCE GeneReport for Unigene cluster: Hs.77854
SABiosciences Expression via Pathway-Focused PCR Array including RGN:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGN
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN |
Orthologs
for RGN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for RGN gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rgn1 , 5 |
regucalcin1, 5 |
86.51(n)1
88.63(a)1 |
|
X (16.04 cM)5
197331 NM_009060.21 NP_033086.11
205497875 |
chicken
(Gallus gallus) |
Aves |
RGN1 |
regucalcin |
73.47(n)
77.93(a) |
|
395480 NM_204729.1 NP_990060.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RGN6 |
-- |
71(a) |
1 ↔ 1 |
3(112098544-112105028) |
African clawed frog
(Xenopus laevis) |
Amphibia |
rgn-A2 |
regucalcin (senescence marker protein-30) |
74.44(n) |
|
AB033368.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.271662 |
Danio rerio clone RK049A3F10 regucalcin mRNA, complete more |
76.79(n) |
|
AY394949.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
regucalcin1 , 3 |
calcium ion binding3
CG1803-PA1 |
34(a)3
47.92(n)1
37.01(a)1 |
|
11A13
321651 NM_132547.21 NP_572775.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
(YBR053C)4
YBR053C1 |
Putative protein of unknown function; induced by cell more4
hypothetical protein1 |
41.14(n)1
30.86(a)1 |
|
2(340751-339675)4
8523421, 4 NP_009609.11, 4 |
ENSEMBL Gene Tree for RGN (if available)
TreeFam Gene Tree for RGN (if available) |
Paralogs
for RGN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RGN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RGN (46937775 - 46952712 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RGN: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGN |
|
Disorders
/ Diseases
for RGN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RGN for disorders About GeneDecksing
OMIM gene information: 300212
OMIM disorders: --
13  diseases for RGN: About MalaCardsscurvy fatty liver disease acute liver failure insulin resistance
liver disease keratoconus hepatocellular carcinoma pancreatic cancer
pancreatitis hepatitis fibrosis carcinoma
neuronitis
2 diseases from the University of Copenhagen DISEASES database for RGN:Scurvy Hepatocellular carcinoma 5 Novoseek disease relationships for RGN gene About this table
Export disorders for RGN gene to outside databases
|
Publications
for RGN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RGN gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with RGN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. (PubMed id 7548213)1, 2, 3, 9 Fujita T....Maruyama N. (1995)
- Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. (PubMed id 10677570)1, 2, 9 Misawa H. and Yamaguchi M. (2000)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. (PubMed id 10360682)1, 9 Fujita T....Maruyama N. (1999)
- Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. (PubMed id 15358188)1, 9 Matsuyama S....Sato N. (2004)
- Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells. (PubMed id 15714273)1, 9 Ishigami A....Maruyama N. (2005)
- Hepatic senescence marker protein-30 is involved in t he progression of nonalcoholic fatty liver disease. (PubMed id 19946731)1, 9 Park H....Okanoue T. (2010)
- Regucalcin is under-expressed in human breast and pro state cancers: Effect of sex steroid hormones. (PubMed id 19347872)1, 9 Maia C....Socorro S. (2009)
- Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay. (PubMed id 18507831)1, 9 Lv S....Wei L. (2008)
|
External Searches for RGN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RGN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RGN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RGN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RGN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RGN gene:
Search GeneIP for patents involving RGN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RGN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RGN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGN | | | OriGene Protein Over-expression Lysate for RGN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RGN | | OriGene 3'-UTR Clone for RGN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGN |
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| | | | Search Tocris compounds for RGN |
| |  |  |  |  | | | | | | Recombinant Protein for RGN |
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 | | | RGN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN |
|  |  |  | | | | ThermoFisher Antibodies for RGN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGN |
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