Aliases for RGN Gene
External Ids for RGN Gene
Previous GeneCards Identifiers for RGN Gene
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for RGN Gene
RGN (Regucalcin) is a Protein Coding gene. Among its related pathways are Metabolism and Pentose phosphate pathway. GO annotations related to this gene include calcium ion binding and gluconolactonase activity.
UniProtKB/Swiss-Prot for RGN Gene
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).