Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGN Gene

protein-coding   GIFtS: 61
GCID: GC0XP046937

Regucalcin

(Previous name: regucalcin (senescence marker protein-30))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
regucalcin1 2     Senescence Marker Protein-301
SMP302 3 5     gluconolactonase2
Senescence Marker Protein 302 3     EC 3.1.1.173
GNL2 3     Gluconolactonase3
RC2 3     SMP-303
Regucalcin (Senescence Marker Protein-30)1     

External Ids:    HGNC: 99891   Entrez Gene: 91042   Ensembl: ENSG000001309887   OMIM: 3002125   UniProtKB: Q154933   

Export aliases for RGN gene to outside databases

Previous GC identifers: GC0XP045740 GC0XP045198 GC0XP045983 GC0XP046695 GC0XP046822 GC0XP044651


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGN Gene:
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed
in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this
protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene
cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Sep 2013)

GeneCards Summary for RGN Gene: 
RGN (regucalcin) is a protein-coding gene. Diseases associated with RGN include scurvy, and acute liver failure, and among its related super-pathways are Glucuronidation and Metabolism. GO annotations related to this gene include gluconolactonase activity and calcium ion binding.

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493
Function: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and
galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro).
Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme
activities (By similarity)

Gene Wiki entry for RGN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGN gene promoter:
         NRSF form 1   FOXD3   NRSF form 2   AREB6   HSF2   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGN promoter sequence
   Search SABiosciences Chromatin IP Primers for RGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3

RGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGN gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP046937:  view genomic region     (about GC identifiers)

Start:
46,937,775 bp from pter      End:
46,952,712 bp from pter
Size:
14,938 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493 (See protein sequence)
Recommended Name: Regucalcin  
Size: 299 amino acids; 33253 Da
Cofactor: Binds 1 divalent metal cation per subunit. Most active with zinc and manganese ions. The physiological
cofactor is most likely calcium or magnesium
Subunit: Monomer
Subcellular location: Cytoplasm (By similarity)
Caution: Gluconolactonase catalyzes a key step in ascorbic acid (vitamin C) biosynthesis, but primates lack the
last enzyme in the pathway and are unable to synthesize vitamin C
4 PDB 3D structures from and Proteopedia for RGN:
3G4E (3D)        3G4H (3D)        4GNB (3D)        4GNC (3D)    
Secondary accessions: A4FTW1 A8K271 Q53FC9 Q5JRR5
Alternative splicing: 2 isoforms:  Q15493-1   Q15493-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGN: NX_Q15493

Explore proteomics data for RGN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15493

  • RGN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGN Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269777.1  NP_001269778.1  NP_004674.1  NP_690608.1  

    ENSEMBL proteins: 
     ENSP00000253303   ENSP00000338400   ENSP00000380365   ENSP00000406568  

    Human Recombinant Protein Products for RGN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RGN
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RGN
    GenScript Custom Purified and Recombinant Proteins Services for RGN
    Novus Biologicals RGN Proteins
    Novus Biologicals RGN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RGN
    Cloud-Clone Corp. Proteins for RGN 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    RGN for ontologies           About GeneDecksing



    RGN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RGN
    GenScript Custom Superior Antibodies Services for RGN
    Novus Biologicals RGN Antibodies
    Abcam antibodies for RGN
    Cloud-Clone Corp. Antibodies for RGN 
    ThermoFisher Antibodies for RGN
    LSBio Antibodies in human, mouse, rat for RGN 

    Assay Products for RGN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RGN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RGN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RGN 
    Cloud-Clone Corp. CLIAs for RGN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005511 SMP-30
     IPR008367 Regucalcin
     IPR011042 6-blade_b-propeller_TolB-like
     IPR013658 SGL

    Graphical View of Domain Structure for InterPro Entry Q15493

    ProtoNet protein and cluster: Q15493

    3 Blocks protein domains:
    IPB005511 Senescence marker protein-30 (SMP-30)
    IPB008367 Regucalcin signature
    IPB013658 SMP-30/Gluconolaconase/LRE-like region


    UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493
    Similarity: Belongs to the SMP-30/CGR1 family


    RGN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGN_HUMAN, Q15493
    Function: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and
    galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro).
    Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme
    activities (By similarity)
    Catalytic activity: D-glucono-1,5-lactone + H(2)O = D-gluconate
    Biophysicochemical properties: Kinetic parameters: KM=2.7 mM for gluconolactone (with Zn(2+) as cofactor); KM=0.6
    mM for gluconolactone (with Mn(2+) as cofactor); KM=1.3 mM for gluconolactone (with Mg(2+) as cofactor); KM=3.7
    mM for gluconolactone (with Ca(2+) as cofactor);

         Genatlas biochemistry entry for RGN:
    rat calcium binding protein (regucalcin) homolog

         Enzyme Number (IUBMB): EC 3.1.1.171

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004341gluconolactonase activity IDA--
    GO:0005509calcium ion binding ISS--
    GO:0008270zinc ion binding IDA--
    GO:0030234enzyme regulator activity IEA--
         
    RGN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RGN:
     Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgn):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size 
     hearing/vestibular/ear  homeostasis/metabolism  integument  liver/biliary system  mortality/aging 
     nervous system  respiratory system  skeleton  vision/eye 

    RGN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rgntm1Aish for RGN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGN
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RGN:
    hsa-miR-485-5p hsa-miR-708* hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidRGN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RGN
    Sirion Biotech Customized adenovirus for overexpression of RGN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RGN (see all 13)
    OriGene ORF clones in mouse, rat for RGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RGN (NM_001126181)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGN
    Sirion Biotech Customized lentivirus for stable overexpression of RGN 
                         Customized lentivirus expression plasmids for stable overexpression of RGN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RGN
    Search LifeMap BioReagents cell lines for RGN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Ascorbate and aldarate metabolism0.61
    2Metabolism
    Metabolic pathways0.40
    3Carbon metabolism
    Carbon metabolism0.37
    4Pentose phosphate pathway
    Pentose phosphate pathway
    5Degradation of aromatic compounds
    Degradation of aromatic compounds

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5         Kegg Pathways  (Kegg details for RGN):
        Pentose phosphate pathway
    Ascorbate and aldarate metabolism
    Metabolic pathways
    Carbon metabolism
    Degradation of aromatic compounds


    RGN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGN

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for RGN (Q154933 ENSP000002533034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1D2Q149953I2D: score=2 
    THRAP108273I2D: score=2 
    TPT1ENSP000003683504STRING: ENSP00000368350
    DUTENSP000003703764STRING: ENSP00000370376
    ATP5A1ENSP000002820504STRING: ENSP00000282050
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis ISS--
    GO:0032781positive regulation of ATPase activity ISS--
    GO:0050848regulation of calcium-mediated signaling ISS--

    RGN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGN

    1 HMDB Compound for RGN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 Novoseek inferred chemical compound relationships for RGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tabun 69.8 1 15247044 (1)
    sarin 58 1 15247044 (1)
    soman 55.4 1 15247044 (1)
    deoxyribonucleic acid 36.9 2 15702226 (1)
    ascorbic acid 28.2 9 17222174 (1), 19801822 (1)
    calcium 27.7 33 18704329 (5), 9753637 (4), 10360682 (3), 8765750 (1) (see all 9)
    superoxide 18.5 2 15902099 (1), 17569552 (1)

    Search CenterWatch for drugs/clinical trials and news about RGN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGN gene (4 alternative transcripts): 
    NM_001282848.1  NM_001282849.1  NM_004683.5  NM_152869.3  

    Unigene Cluster for RGN:

    Regucalcin (senescence marker protein-30)
    Hs.77854  [show with all ESTs]
    Unigene Representative Sequence: NM_152869
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352078 ENST00000469346 ENST00000336169 ENST00000475448 ENST00000397180(uc004dgz.1 uc004dha.1 uc010nho.1)
    ENST00000457380(uc010nhp.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGN
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RGN:
    hsa-miR-485-5p hsa-miR-708* hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidRGN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGN
    Clone
    Products:
         
    OriGene clones in human, mouse for RGN (see all 13)
    OriGene ORF clones in mouse, rat for RGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RGN (NM_001126181)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGN
    Sirion Biotech Customized lentivirus for stable overexpression of RGN 
                         Customized lentivirus expression plasmids for stable overexpression of RGN 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RGN
    OriGene qSTAR qPCR primer pairs in human, mouse for RGN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGN

    Additional mRNA sequence: 

    AB028125.1 AB032064.1 AK223360.1 AK290136.1 BC050371.1 BC058880.1 BC073173.1 D31815.1 

    6 DOTS entries:

    DT.100748481  DT.101980961  DT.99998879  DT.91742681  DT.99989586  DT.99999502 

    24/66 AceView cDNA sequences (see all 66):

    NM_152869 D31815 BC073173 BC050371 BC058880 AA349125 CB161948 CD106286 
    NM_004683 BM984993 BQ005205 BV204050 BE048889 AI767740 BI517593 AW243248 
    BF939573 AB028125 AV704357 AI354934 BU074155 BE348729 BX951543 AI804699 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RGN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -     -     -                 -                           
    SP2:                                                  -                           
    SP3:                    -     -     -                 -     -                     
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for RGN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGN expression in normal human tissues (normalized intensities)      RGN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTTTGGA
    RGN Expression
    About this image


    RGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             adrenal gland ; glandular cells   
             Adrenal Cortex   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
             kidney ; cells in tubules   
     
     Pancreas (Endocrine System)
             pancreas ; exocrine glandular cells   

    See RGN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGN

    SOURCE GeneReport for Unigene cluster: Hs.77854
        SABiosciences Expression via Pathway-Focused PCR Array including RGN: 
              Nephrotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RGN
    OriGene qSTAR qPCR primer pairs in human, mouse for RGN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RGN gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgn1 , 5 regucalcin1, 5 86.51(n)1
    88.63(a)1
      X (16.04 cM)5
    197331  NM_009060.21  NP_033086.11 
     205497875 
    chicken
    (Gallus gallus)
    Aves RGN1 regucalcin 73.47(n)
    77.93(a)
      395480  NM_204729.1  NP_990060.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGN6
    --
    --
    71(a)
    66(a)
    1 ↔ 1
    possible ortholog
    3(112098541-112108045)
    3(112110892-112137634)
    African clawed frog
    (Xenopus laevis)
    Amphibia rgn-A2 regucalcin (senescence marker protein-30) 74.44(n)    AB033368.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271662 Danio rerio clone RK049A3F10 regucalcin mRNA, complete more 76.79(n)    AY394949.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta regucalcin1 , 3 calcium ion binding3
    CG1803-PA1
    34(a)3
    47.92(n)1
    37.01(a)1
      11A13
    321651  NM_132547.21  NP_572775.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YBR053C)4
    YBR053C1
    Putative protein of unknown function; induced by cell more4
    hypothetical protein1
    41.14(n)1
    30.86(a)1
      2(340751-339675)4
    8523421, 4  NP_009609.11, 4 


    ENSEMBL Gene Tree for RGN (if available)
    TreeFam Gene Tree for RGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/350 SNPs in RGN are shown (see all 350)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842399331,2
    --46935788(+) GTTTTG/TTTTTT 2 -- us2k10--------
    rs1381884181,2
    C--46935852(+) TATCAC/TGGCTC 2 -- us2k10--------
    rs1896415791,2
    --46935886(+) TCAAGC/TGATGT 2 -- us2k10--------
    rs1811139751,2
    --46935934(+) ACCACA/GCCTGG 2 -- us2k10--------
    rs1859563031,2
    --46935935(+) CCACGC/TCTGGC 2 -- us2k10--------
    rs344319601,2
    C,F--46936098(+) AACCTC/TTATGT 2 -- us2k11Minor allele frequency- T:0.50NA 4
    rs1442209591,2
    --46936492(+) GGCCTA/GTATCC 2 -- us2k10--------
    rs732019721,2
    C,F--46936663(+) CTGGAT/CTCAAG 2 -- us2k12Minor allele frequency- C:0.00NA 3
    rs1910103751,2
    --46936724(+) ACCACA/GCCCAG 2 -- us2k10--------
    rs1433046411,2
    C--46936762(+) TTTCAC/TTCTTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGN (46937775 - 46952712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RGN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv513604CNV Insertion21212237
    nsv508767CNV Insertion20534489
    esv1734378CNV Insertion17803354

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RGN
    DNA2.0 Custom Variant and Variant Library Synthesis for RGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300212    OMIM disorders: --

    11 diseases for RGN:    About MalaCards
    scurvy    acute liver failure    fatty liver disease    keratoconus
    liver disease    hepatocellular carcinoma    insulin resistance    pancreatic cancer
    pancreatitis    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RGN:
    Scurvy

    RGN for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for RGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis 19.8 1 9059996 (1)
    hepatocellular carcinoma 14.3 2 15358188 (1), 19801822 (1)
    necrosis 0 1 15358188 (1)
    tumors 0 4 19347872 (2), 16136218 (1), 15358188 (1)
    cancer 0 1 19347872 (1)


    Export disorders for RGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGN gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with RGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. (PubMed id 7548213)1, 2, 3, 9 Fujita T....Maruyama N. (1995)
    2. Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions . (PubMed id 20329768)1, 2, 9 Chakraborti S. and Bahnson B.J. (2010)
    3. Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. (PubMed id 10677570)1, 2, 9 Misawa H. and Yamaguchi M. (2000)
    4. Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase. (PubMed id 23349732)1, 2 Aizawa S.... Senda T. (2013)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Senescence marker protein-30 (SMP30): structure and biological function. (PubMed id 9920722)1, 9 Fujita T. (1999)
    8. Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. (PubMed id 10360682)1, 9 Fujita T....Maruyama N. (1999)
    9. Senescence marker protein-30 (SMP30) rescues cell death by enhancing plasma membrane Ca(2+)-pumping activity in Hep G2 cells. (PubMed id 9753637)1, 9 Fujita T....Maruyama N. (1998)
    10. Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. (PubMed id 15358188)1, 9 Matsuyama S....Sato N. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9104 HGNC: 9989 AceView: RGN Ensembl:ENSG00000130988 euGenes: HUgn9104
    ECgene: RGN Kegg: 9104 H-InvDB: RGN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGN gene:
    Search GeneIP for patents involving RGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RGN  
     OriGene qPCR primer pairs and template standards for RGN   OriGene Protein Over-expression Lysate for RGN  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RGN  
     OriGene qSTAR qPCR primer pairs in human, mouse for RGN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RGN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RGN   OriGene Custom Protein Services for RGN  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGN
     QIAGEN SeqTarget long-range PCR primers for resequencing RGN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGN
     GenScript Custom Purified and Recombinant Proteins Services for RGN GenScript cDNA clones with any tag delivered in your preferred vector for RGN
     GenScript Custom Assay Services for RGN GenScript Custom Superior Antibodies Services for RGN
     GenScript Custom overexpressing Cell Line Services for RGN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RGN promoter
     Search Chromatin IP Primers for RGN
     RT2 qPCR Primer Assay in human, mouse, rat RGN
     GNC Network for RGN
     SABiosciences PCR Arrays including human, mouse, rat RGN
     Search Tocris compounds for RGN
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RGN antibodies
     RGN proteins
     RGN lysates
     Antibodies for RGN
     See all of Abcam's Antibodies, Kits and Proteins for RGN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RGN




     Proteins for RGN
     Antibodies for RGN
     ELISAs for RGN
     CLIAs for RGN
     Search LifeMap BioReagents cell lines for RGN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGN
     SwitchGear 3'UTR luciferase reporter plasmids for RGN
     SwitchGear Promoter luciferase reporter plasmids for RGN
     ThermoFisher Antibodies for RGN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RGN
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGN
    Customized:
     lentivirus for stable overexpression of RGN
     lentivirus expression plasmids for stable overexpression of RGN
     adenovirus for overexpression of RGN
     LSBio Antibodies in human, mouse, rat for RGN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RGN gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4