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Aliases for RGMB Gene

Aliases for RGMB Gene

  • Repulsive Guidance Molecule Family Member B 2 3
  • DRAGON 3 4 6
  • DRG11-Responsive Axonal Guidance And Outgrowth Of Neurite 3 4
  • RGM Domain Family, Member B 2 3
  • Repulsive Guidance Molecule B 3
  • RGM Domain Family Member B 3

External Ids for RGMB Gene

Previous GeneCards Identifiers for RGMB Gene

  • GC05P098181
  • GC05P098132
  • GC05P093292

Summaries for RGMB Gene

Entrez Gene Summary for RGMB Gene

  • RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]

GeneCards Summary for RGMB Gene

RGMB (Repulsive Guidance Molecule Family Member B) is a Protein Coding gene. Diseases associated with RGMB include dermatomycosis and chronic monocytic leukemia. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include identical protein binding. An important paralog of this gene is RGMA.

UniProtKB/Swiss-Prot for RGMB Gene

  • Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.

Gene Wiki entry for RGMB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGMB Gene

Genomics for RGMB Gene

Regulatory Elements for RGMB Gene

Transcription factor binding sites by QIAGEN in the RGMB gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGMB Gene

Start:
98,768,650 bp from pter
End:
98,798,643 bp from pter
Size:
29,994 bases
Orientation:
Plus strand

Genomic View for RGMB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGMB Gene

Proteins for RGMB Gene

  • Protein details for RGMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NW40-RGMB_HUMAN
    Recommended name:
    RGM domain family member B
    Protein Accession:
    Q6NW40
    Secondary Accessions:
    • D6R9A0
    • Q8NC92

    Protein attributes for RGMB Gene

    Size:
    437 amino acids
    Molecular mass:
    47547 Da
    Quaternary structure:
    • Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B (By similarity). The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that brings two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA.
    SequenceCaution:
    • Sequence=AAH67736.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11268.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGMB Gene

neXtProt entry for RGMB Gene

Proteomics data for RGMB Gene at MOPED

Post-translational modifications for RGMB Gene

  • Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds
  • GPI-anchored.
  • Glycosylation at Asn120, Thr127, Thr135, and Asn383
  • Modification sites at PhosphoSitePlus

Other Protein References for RGMB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RGMB Gene

Domains for RGMB Gene

Protein Domains for RGMB Gene

Suggested Antigen Peptide Sequences for RGMB Gene

Graphical View of Domain Structure for InterPro Entry

Q6NW40

UniProtKB/Swiss-Prot:

RGMB_HUMAN :
  • Q6NW40
Family:
  • Belongs to the repulsive guidance molecule (RGM) family.
genes like me logo Genes that share domains with RGMB: view

No data available for Gene Families for RGMB Gene

Function for RGMB Gene

Molecular function for RGMB Gene

UniProtKB/Swiss-Prot Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.

Gene Ontology (GO) - Molecular Function for RGMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015026 coreceptor activity IBA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with RGMB: view

Phenotypes for RGMB Gene

MGI mutant phenotypes for RGMB:
inferred from 1 alleles
GenomeRNAi human phenotypes for RGMB:
genes like me logo Genes that share phenotypes with RGMB: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGMB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGMB Gene

Localization for RGMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGMB Gene

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGMB Gene COMPARTMENTS Subcellular localization image for RGMB gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RGMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISS --
GO:0005886 plasma membrane IBA --
GO:0045121 membrane raft IEA --
GO:0046658 anchored component of plasma membrane ISS --
genes like me logo Genes that share ontologies with RGMB: view

Pathways for RGMB Gene

genes like me logo Genes that share pathways with RGMB: view

Pathways by source for RGMB Gene

1 BioSystems pathway for RGMB Gene
3 Reactome pathways for RGMB Gene

Interacting Proteins for RGMB Gene

Gene Ontology (GO) - Biological Process for RGMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion ISS --
GO:0007165 signal transduction ISS --
GO:0007411 axon guidance TAS --
GO:0030509 BMP signaling pathway ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with RGMB: view

Transcripts for RGMB Gene

Unigene Clusters for RGMB Gene

RGM domain family, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGMB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RGMB
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGMB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
SP1: - -
SP2: -
SP3:

Relevant External Links for RGMB Gene

GeneLoc Exon Structure for
RGMB
ECgene alternative splicing isoforms for
RGMB

Expression for RGMB Gene

mRNA expression in normal human tissues for RGMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGMB Gene

This gene is overexpressed in Esophagus - Muscularis (5.1) and Esophagus - Gastroesophageal Junction (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGMB Gene

SOURCE GeneReport for Unigene cluster for RGMB Gene Hs.526902

genes like me logo Genes that share expressions with RGMB: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGMB Gene

Orthologs for RGMB Gene

This gene was present in the common ancestor of animals.

Orthologs for RGMB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGMB 35
  • 99.51 (n)
  • 99.37 (a)
RGMB 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGMB 35
  • 87.24 (n)
  • 91.33 (a)
RGMB 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGMB 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgmb 35
  • 87.95 (n)
  • 91.79 (a)
Rgmb 16
Rgmb 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGMB 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGMB 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgmb 35
  • 86.29 (n)
  • 87.13 (a)
chicken
(Gallus gallus)
Aves RGMB 35
  • 76 (n)
  • 78.63 (a)
RGMB 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGMB 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75814 35
rgmb 35
  • 71.99 (n)
  • 80.99 (a)
zebrafish
(Danio rerio)
Actinopterygii rgmb 35
  • 69.41 (n)
  • 71.15 (a)
rgmb 36
  • 61 (a)
OneToMany
rgmb 36
  • 61 (a)
OneToMany
rgmd 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea drag-1 35
  • 44 (n)
  • 33.23 (a)
drag-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for RGMB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGMB Gene

ENSEMBL:
Gene Tree for RGMB (if available)
TreeFam:
Gene Tree for RGMB (if available)

Paralogs for RGMB Gene

Paralogs for RGMB Gene

Selected SIMAP similar genes for RGMB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGMB: view

Variants for RGMB Gene

Sequence variations from dbSNP and Humsavar for RGMB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs13541 -- 98,795,801(+) AAATA(A/G)TATGA utr-variant-3-prime
rs331550 -- 98,781,761(+) CATCC(A/G)GTCAT intron-variant
rs331551 -- 98,782,003(+) AAAAG(G/T)TGGAG intron-variant
rs331552 -- 98,783,014(+) TTGCC(C/T)CATCT intron-variant
rs970079 -- 98,784,160(-) ATCTG(C/T)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGMB Gene

Variant ID Type Subtype PubMed ID
nsv882414 CNV Gain 21882294

Relevant External Links for RGMB Gene

HapMap Linkage Disequilibrium report
RGMB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGMB Gene

Disorders for RGMB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RGMB Gene including...

Search for RGMB Gene in MalaCards »

(2) University of Copenhagen DISEASES for RGMB Gene

Relevant External Links for RGMB

Human Genome Epidemiology (HuGE) Navigator
RGMB
genes like me logo Genes that share disorders with RGMB: view

No data available for UniProtKB/Swiss-Prot for RGMB Gene

Publications for RGMB Gene

  1. Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. (PMID: 19324014) Liu X. … Yamashita T. (Biochem. Biophys. Res. Commun. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub. (PMID: 23744777) Bell C.H. … Siebold C. (Science 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. DRAGON, a bone morphogenetic protein co-receptor. (PMID: 15671031) Samad T.A. … Woolf C.J. (J. Biol. Chem. 2005) 3

Products for RGMB Gene

Sources for RGMB Gene

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