Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGMB Gene

protein-coding   GIFtS: 57
GCID: GC05P098132

RGM domain family, member B

 Explore 5 diseases affiliated with
RGMB via our new
 Human Malady Compendium 
Biological research products
for RGMB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RGM Domain Family, Member B1 2
DRAGON2 3 5
DRG11-Responsive Axonal Guidance And Outgrowth Of Neurite2 3
FLJ904061
Repulsive Guidance Molecule B2
RGM Domain Family Member B2

External Ids:    HGNC: 268961   Entrez Gene: 2857042   Ensembl: ENSG000001741367   OMIM: 6126875   UniProtKB: Q6NW403   

Export aliases for RGMB gene to outside databases

Previous GC identifers: GC05P098181 GC05P093292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGMB:
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM
607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 (PubMed
15671031)).(supplied by OMIM, Apr 2009)

UniProtKB/Swiss-Prot: RGMB_HUMAN, Q6NW40
Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing
nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling
(By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth

Gene Wiki entry for RGMB


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGMB gene promoter:
         SRY   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGMB promoter sequence
   Search SABiosciences Chromatin IP Primers for RGMB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q21.1

RGMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGMB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P098132:  view genomic region     (about GC identifiers)

Start:
98,104,354 bp from pter      End:
98,134,347 bp from pter
Size:
29,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGMB_HUMAN, Q6NW40 (See protein sequence)
Recommended Name: RGM domain family member B precursor  
Size: 437 amino acids; 47547 Da
Subunit: Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By
similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B
(By similarity)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft (By similarity)
Sequence caution: Sequence=AAH67736.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC11268.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: D6R9A0 Q8NC92

Explore the universe of human proteins at neXtProt for RGMB: NX_Q6NW40

Post-translational modifications:

  • GPI-anchored (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6NW40

  • RGMB Protein expression data from MOPED and PaxDb:    About this image 
    RGMB Protein Expression
    REFSEQ proteins: NP_001012779.2  
    ENSEMBL proteins: 
     ENSP00000308219   ENSP00000423256  
    Reactome Protein details: Q6NW40
    Human Recombinant Protein Products for RGMB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for RGMB (RGM-B)
    Enzo Life Sciences proteins for RGMB
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for RGMB 
    GenScript Custom Purified and Recombinant Proteins Services for RGMB
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RGMB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment ISS--
    GO:0045121membrane raft IEA--
    GO:0046658anchored to plasma membrane ISS--

    RGMB for ontologies           About GeneDecksing



    RGMB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RGMB (RGM-B)
    OriGene Antibodies: RGMB
    OriGene Custom Antibody Services for RGMB 
    GenScript Custom Superior Antibodies Services for RGMB
    Novus Biologicals RGMB Antibody
    Abcam antibodies for RGMB 
    Uscn Antibodies for RGMB
    ThermoFisher Antibody for RGMB

    Assay Products for RGMB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for RGMB (RGM-B)
    GenScript Custom Assay Services for RGMB
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RGMB


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RGMB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR009496 RGM_C
     IPR010536 RGM_N

    Graphical View of Domain Structure for InterPro Entry Q6NW40

    ProtoNet protein and cluster: Q6NW40

    1 Blocks protein family: IPB009496 Repulsive guidance molecule

    UniProtKB/Swiss-Prot: RGMB_HUMAN, Q6NW40
    Similarity: Belongs to the repulsive guidance molecule (RGM) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGMB_HUMAN, Q6NW40
    Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing
    nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling
    (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042802identical protein binding ISS--
         
    RGMB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RGMB:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rgmb):
     mortality/aging 

    RGMB for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RGMB 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: RGMB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGMB
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate RGMB (see all 91):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidRGMB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGMB (see all 3)
    OriGene siRNA: RGMB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGMB
    Sirion Biotech Custom design and validation of potent shRNA sequences against RGMB 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RGMB
    Sirion Biotech Customized adenovirus for overexpression of RGMB 
    Sirion Biotech Customized adenovirus for potent knockdown of RGMB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGMB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGMB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RGMB (NM_001012761)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RGMB
    Search LifeMap BioReagents cell lines for RGMB
    Sirion Biotech Customized stable knockdown cell line services for RGMB 
    Sirion Biotech Customized inducible knockdown cell line services for RGMB
    Sirion Biotech Customized stable overexpressing cell line services for RGMB
    Sirion Biotech Customized inducible overexpressing cell line services for RGMB

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    Axon guidance1.00
    Developmental Biology0.69
    2Netrin-1 signaling
    Netrin-1 signaling1.00
    3Signaling by BMP
    BMP receptor signaling0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for RGMB 
        BMP receptor signaling

    3        Reactome Pathways for RGMB
        Developmental Biology
    Netrin-1 signaling
    Axon guidance



    RGMB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGMB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for RGMB (Q6NW403 ENSP000003082194) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR1AP368943, ENSP000002247644I2D: score=1 STRING: ENSP00000224764
    BAMBIENSP000003646834STRING: ENSP00000364683
    BMP2ENSP000003681044STRING: ENSP00000368104
    BMP4ENSP000002454514STRING: ENSP00000245451
    BMPR1BENSP000002645684STRING: ENSP00000264568
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ISS--
    GO:0007165signal transduction ISS--
    GO:0007411axon guidance TAS--
    GO:0030509BMP signaling pathway ISS--
    GO:0045893positive regulation of transcription, DNA-dependent ISS--

    RGMB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGMB
    Search CenterWatch for drugs/clinical trials and news about RGMB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGMB gene (2 alternative transcripts): 
    NM_173670.2  NM_001012761.2  

    Unigene Cluster for RGMB:

    RGM domain family, member B
    Hs.526902  [show with all ESTs]
    Unigene Representative Sequence: NM_001012761
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504776 ENST00000505265 ENST00000434027(uc003knb.2) ENST00000308234(uc003knc.3)
    ENST00000507054 ENST00000513185 ENST00000508978

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: RGMB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGMB
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate RGMB (see all 91):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidRGMB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGMB (see all 3)
    OriGene siRNA: RGMB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGMB
    Sirion Biotech Custom design and validation of potent shRNA sequences against RGMB 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGMB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGMB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RGMB (NM_001012761)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMB 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGMB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGMB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMB

    Additional cDNA sequence: 

    AK054622.1 AK074887.1 AK125284.1 BC020513.1 BC044231.1 BC067736.1 

    5 DOTS entries:

    DT.414777  DT.203356  DT.40290433  DT.75147495  DT.97771808 

    24/133 AceView cDNA sequences (see all 133):

    AA470819 BC020513 AI308931 BG820746 BQ021208 AI130956 BE855765 BF724316 
    BG741703 AK054622 CB127183 N35457 AA569968 CB118185 BQ212600 BF724900 
    BU156610 BX109418 AI919210 BM706050 AI468297 BI966210 AI383006 BM905111 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RGMB    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
    SP1:        -     -               
    SP2:              -               
    SP3:                              


    ECgene alternative splicing isoforms for RGMB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGMB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGTCTTTA
    RGMB Expression
    About this image
    See RGMB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGMB

    SOURCE GeneReport for Unigene cluster: Hs.526902
        SABiosciences Custom PCR Arrays for RGMB

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGMB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGMB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGMB gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgmb1 , 5 RGM domain family, member B1, 5 87.91(n)1
    90.3(a)1
      17 (8.96 cM)5
    687991  NM_178615.31  NP_848730.21 
     158062535 
    chicken
    (Gallus gallus)
    Aves RGMB1 RGM domain family, member B 74.47(n)
    76.36(a)
      427277  XM_424860.3  XP_424860.3 
    lizard
    (Anolis carolinensis)
    Reptilia RGMB6
    --
    80(a)
    1 ↔ 1
    2(27368061-27386740)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC758142 hypothetical protein MGC75814 78.34(n)    BC061325.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgmb1 RGM domain family, member B 68.13(n)
    69.33(a)
      414273  NM_001001727.1  NP_001001727.1 
    worm
    (Caenorhabditis elegans)
    Secernentea drag-11 Protein DRAG-1 44.32(n)
    34.47(a)
      190602  NM_058480.3  NP_490881.3 


    ENSEMBL Gene Tree for RGMB (if available)
    TreeFam Gene Tree for RGMB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGMB gene
    RGMA2  HFE22  
    2 SIMAP similar genes for RGMB using alignment to 2 protein entries:     RGMB_HUMAN (see all proteins):
    RGMA    HFE2

    RGMB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/434 NCBI SNPs in RGMB are shown (see all 434    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807186651,2
    --98103149(+) AATGTC/TCAAGT 1 -- us2k10--------
    rs1863771471,2
    --98103225(+) ATGATC/GTGATG 1 -- us2k10--------
    rs1912316661,2
    --98103361(+) AGCAGC/GAGAGG 1 -- us2k10--------
    rs799122441,2
    F--98103443(+) CATCAT/GTATTT 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1380629531,2
    C--98103621(+) TGGGG-/TTTTTT 1 -- us2k10--------
    rs1388286751,2
    --98103752(+) AGGTG-/AAAAAA 1 -- us2k10--------
    rs1818929931,2
    --98103759(+) AAAAAC/TACTAA 1 -- us2k10--------
    rs13632981,2
    C,F,H--98103849(+) AATTAT/ATGCCT 1 -- us2k1 tfbs314Minor allele frequency- A:0.00NS EA NA WA CSA 548
    rs77312221,2
    C,F,H--98104055(+) AGCTGG/CAGAGG 1 -- us2k15Minor allele frequency- C:0.01NS EA WA 516
    rs1869170061,2
    --98104064(+) GGGTCA/GTAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGMB (98104354 - 98134347 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RGMB: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGMB
    DNA2.0 Custom Variant and Variant Library Synthesis for RGMB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RGMB for disorders           About GeneDecksing

    OMIM gene information: 612687    OMIM disorders: --

    5 diseases for RGMB:    About MalaCards
    spinal cord injury    basilar artery occlusion    dermatomycosis    breast cancer
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for RGMB:
    Dermatomycosis     Chronic monocytic leukemia
    Human Genome Epidemiology (HuGE) Navigator: RGMB (1 document)

    Export disorders for RGMB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGMB gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with RGMB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Repulsive guidance molecule B (RGMB) plays negative ro les in breast cancer by coordinating BMP signaling. (PubMed id 22415859)1 Li J....Jiang W.G. (2012)
    4. Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of pr ostate cancer cells. (PubMed id 22076499)1 Li J....Jiang W.G. (2012)
    5. Potential prognostic value of repulsive guidance mole cules in breast cancer. (PubMed id 21617229)1 Li J....Jiang W.G. (2011)
    6. Variants in several genomic regions associated with a sperger disorder. (PubMed id 21182207)1 Salyakina D....Pericak-Vance M.A. (2010)
    7. Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. (PubMed id 19324014)2 Liu X.... Yamashita T. (2009)
    8. DRAGON, a bone morphogenetic protein co-receptor. (PubMed id 15671031)1 Samad T.A....Woolf C.J. (2005)
    9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    10. DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. (PubMed id 14985445)1 Samad T.A....Woolf C.J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285704 HGNC: 26896 AceView: RGMB Ensembl:ENSG00000174136 euGenes: HUgn285704
    ECgene: RGMB H-InvDB: RGMB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGMB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGMB gene:
    Search GeneIP for patents involving RGMB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RGMB (RGM-B)   Browse Cell Culture Products  
     ELISAs for RGMB (RGM-B)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for RGMB (RGM-B)  
     OriGene Antibodies for RGMB   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGMB   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGMB  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RGMB   OriGene 3'-UTR Clone for RGMB  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGMB   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGMB  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RGMB   OriGene Custom Protein Services for RGMB  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGMB
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGMB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGMB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGMB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMB
     GenScript Custom Purified and Recombinant Proteins Services for RGMB GenScript cDNA clones with any tag delivered in your preferred vector for RGMB
     GenScript Custom Assay Services for RGMB GenScript Custom Superior Antibodies Services for RGMB
     GenScript Custom overexpressing Cell Line Services for RGMB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RGMB promoter
     Search Chromatin IP Primers for RGMB
     RT2 qPCR Primer Assay in human, mouse, rat RGMB
     GNC Network for RGMB
     SABiosciences Custom PCR Arrays for RGMB
     Search Tocris compounds for RGMB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for RGMB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RGMB antibodies
     Antibodies for RGMB
     See all of Abcam's Antibodies, Kits and Proteins for RGMB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RGMB Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RGMB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMB
     SwitchGear 3'UTR luciferase reporter plasmids for RGMB
     SwitchGear Promoter luciferase reporter plasmids for RGMB
     ThermoFisher Antibody for RGMB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMB
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RGMB
    Sirion Biotech Customized:
     stable knockdown cell line services for RGMB
     inducible knockdown cell line services for RGMB
     design and validation of potent shRNA sequences against RGMB
     adenovirus for potent knockdown of RGMB
     adenovirus for overexpression of RGMB
     stable overexpressing cell line services for RGMB
     inducible overexpressing cell line services for RGMB
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RGMB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4