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RGMB Gene

protein-coding   GIFtS: 60
GCID: GC05P098132

Repulsive Guidance Molecule Family Member B

(Previous names: RGM domain family, member B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Repulsive Guidance Molecule Family Member B1 2
DRAGON2 3 5
RGM Domain Family, Member B1 2
DRG11-Responsive Axonal Guidance And Outgrowth Of Neurite2 3
Repulsive Guidance Molecule B2
RGM Domain Family Member B2

External Ids:    HGNC: 268961   Entrez Gene: 2857042   Ensembl: ENSG000001741367   OMIM: 6126875   UniProtKB: Q6NW403   
ORGUL members:         

Export aliases for RGMB gene to outside databases

Previous GC identifers: GC05P098181 GC05P093292


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGMB Gene:
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA,
MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 (PubMed
15671031)).(supplied by OMIM, Apr 2009)

GeneCards Summary for RGMB Gene:
RGMB (repulsive guidance molecule family member b) is a protein-coding gene. Diseases associated with RGMB include dermatomycosis, and chronic monocytic leukemia. GO annotations related to this gene include identical protein binding. An important paralog of this gene is RGMA.

UniProtKB/Swiss-Prot: RGMB_HUMAN, Q6NW40
Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the
developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates
BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth

Gene Wiki entry for RGMB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGMB gene promoter:
         SRY   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGMB promoter sequence
   Search Chromatin IP Primers for RGMB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q21.1

RGMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGMB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P098132:  view genomic region     (about GC identifiers)

Start:
98,104,354 bp from pter      End:
98,134,347 bp from pter
Size:
29,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RGMB_HUMAN, Q6NW40 (See protein sequence)
Recommended Name: RGM domain family member B precursor  
Size: 437 amino acids; 47547 Da
Subunit: Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By
similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor
ACVR2B (By similarity)
Sequence caution: Sequence=AAH67736.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC11268.1; Type=Miscellaneous discrepancy; Note=Intron retention;
3 PDB 3D structures from and Proteopedia for RGMB:
4BQ6 (3D)        4BQ7 (3D)        4BQ8 (3D)    
Secondary accessions: D6R9A0 Q8NC92

Explore the universe of human proteins at neXtProt for RGMB: NX_Q6NW40

Explore proteomics data for RGMB at MOPED

Post-translational modifications: 

  • GPI-anchored (By similarity)1
  • Glycosylation2 at Asn120, Thr127, Thr135, Asn383
  • Modification sites at PhosphoSitePlus

  • See RGMB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012779.2  
    ENSEMBL proteins: 
     ENSP00000308219   ENSP00000423256  
    Reactome Protein details: Q6NW40

    RGMB Human Recombinant Protein Products:

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    RGMB Antibody Products:

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    RGMB Assay Products:

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    Cloud-Clone Corp. CLIAs for RGMB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009496 RGM_C
     IPR010536 RGM_N

    Graphical View of Domain Structure for InterPro Entry Q6NW40

    ProtoNet protein and cluster: Q6NW40

    1 Blocks protein domain: IPB009496 Repulsive guidance molecule

    UniProtKB/Swiss-Prot: RGMB_HUMAN, Q6NW40
    Similarity: Belongs to the repulsive guidance molecule (RGM) family


    RGMB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGMB_HUMAN, Q6NW40
    Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the
    developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates
    BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042802identical protein binding ISS--
         
    RGMB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RGMB:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rgmb):
     mortality/aging 

    RGMB for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGMB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RGMB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGMB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGMB

    miRNA
    Products:
        
    miRTarBase miRNAs that target RGMB:
    hsa-mir-421 (MIRT016114), hsa-mir-30b-5p (MIRT023409), hsa-mir-769-5p (MIRT016098), hsa-mir-27b-3p (MIRT046176), hsa-mir-130b-3p (MIRT044170)

    Block miRNA regulation of human, mouse, rat RGMB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGMB (see all 91):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidRGMB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RGMB

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RGMB (NM_001012761)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMB

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RGMB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGMB_HUMAN, Q6NW40: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    cytosol1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment ISS--
    GO:0045121membrane raft IEA--
    GO:0046658anchored component of plasma membrane ISS--

    RGMB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGMB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Signaling by BMP
    BMP receptor signaling0.31
    3Netrin-1 signaling
    Netrin-1 signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RGMB
        BMP receptor signaling

    1 Reactome Pathway for RGMB
        Netrin-1 signaling



    RGMB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGMB
    Interactions:

        GeneGlobe Interaction Network for RGMB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGMB (Q6NW403 ENSP000003082194) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR1AP368943I2D: score=1 
    BAMBIENSP000003646834STRING: ENSP00000364683
    BMP2ENSP000003681044STRING: ENSP00000368104
    BMP4ENSP000002454514STRING: ENSP00000245451
    BMPR1BENSP000002645684STRING: ENSP00000264568
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ISS--
    GO:0007165signal transduction ISS--
    GO:0007411axon guidance TAS--
    GO:0030509BMP signaling pathway ISS--
    GO:0045893positive regulation of transcription, DNA-templated ISS--

    RGMB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGMB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RGMB gene (2 alternative transcripts): 
    NM_173670.2  NM_001012761.2  

    Unigene Cluster for RGMB:

    RGM domain family, member B
    Hs.526902  [show with all ESTs]
    Unigene Representative Sequence: NM_001012761
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504776 ENST00000505265 ENST00000434027(uc003knb.2) ENST00000308234(uc003knc.3)
    ENST00000507054 ENST00000513185 ENST00000508978
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RGMB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGMB (see all 91):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidRGMB 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat RGMB
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGMB (NM_001012761)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMB
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RGMB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGMB
      QuantiTect SYBR Green Assays in human, mouse, rat RGMB
      QuantiFast Probe-based Assays in human, mouse, rat RGMB

    Additional mRNA sequence: 

    AK054622.1 AK074887.1 AK125284.1 BC020513.1 BC044231.1 BC067736.1 

    5 DOTS entries:

    DT.414777  DT.203356  DT.40290433  DT.75147495  DT.97771808 

    Selected AceView cDNA sequences (see all 133):

    AI383006 BM706050 BG741703 BU156610 AA569968 AI468297 BQ021208 CB118185 
    BX109418 BM905111 BG675151 BF724316 BG820746 BF724900 AA470819 AI740728 
    N35457 BE855765 BI966210 AI308931 CB127183 AI130956 BC020513 AK054622 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RGMB    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
    SP1:        -     -               
    SP2:              -               
    SP3:                              


    ECgene alternative splicing isoforms for RGMB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGMB expression in normal human tissues (normalized intensities)      RGMB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTCTTTA
    RGMB Expression
    About this image


    RGMB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Metencephalon
    RGMB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGMB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.526902
        Custom PCR Arrays for RGMB
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGMB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgmb1 , 5 RGM domain family, member B5
    repulsive guidance molecule family member B1
    87.95(n)1
    91.79(a)1
      17 (8.96 cM)5
    687991  NM_178615.31  NP_848730.21 
     158062535 
    chicken
    (Gallus gallus)
    Aves RGMB1 RGM domain family, member B 76(n)
    78.63(a)
      427277  XM_424860.4  XP_424860.4 
    lizard
    (Anolis carolinensis)
    Reptilia RGMB6
    repulsive guidance molecule family member b
    72(a)
    1 ↔ 1
    2(27342180-27386383)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC758142 hypothetical protein MGC75814 78.34(n)    BC061325.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgmb1 RGM domain family, member B 69.41(n)
    71.15(a)
      414273  NM_001001727.1  NP_001001727.1 
    worm
    (Caenorhabditis elegans)
    Secernentea drag-11 drag-1 44(n)
    33.23(a)
      190602  NM_058480.4  NP_490881.4 


    ENSEMBL Gene Tree for RGMB (if available)
    TreeFam Gene Tree for RGMB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGMB gene
    RGMA2  HFE22  
    2 SIMAP similar genes for RGMB using alignment to 2 protein entries:     RGMB_HUMAN (see all proteins):
    RGMA    HFE2

    RGMB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGMB (see all 448)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807186651,2
    --98103149(+) AATGTC/TCAAGT 1 -- us2k10--------
    rs1863771471,2
    --98103225(+) ATGATC/GTGATG 1 -- us2k10--------
    rs1912316661,2
    --98103361(+) AGCAGC/GAGAGG 1 -- us2k10--------
    rs799122441,2
    C,F--98103443(+) CATCAT/GTATTT 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1380629531,2
    C--98103621(+) TGGGG-/TTTTTT 1 -- us2k10--------
    rs1388286751,2
    C--98103752(+) AGGTG-/AAAAAA 1 -- us2k10--------
    rs1818929931,2
    --98103759(+) AAAAAC/TACTAA 1 -- us2k10--------
    rs13632981,2
    C,F,H--98103849(+) AATTAT/ATGCCT 1 -- us2k1 tfbs314Minor allele frequency- A:0.00NS EA NA WA CSA 548
    rs77312221,2
    C,F,H--98104055(+) AGCTGG/CAGAGG 1 -- us2k15Minor allele frequency- C:0.01NS EA WA 516
    rs1869170061,2
    --98104064(+) GGGTCA/GTAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGMB (98104354 - 98134347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RGMB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882414CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGMB
    DNA2.0 Custom Variant and Variant Library Synthesis for RGMB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612687    OMIM disorders: --

    10 diseases for RGMB:    About MalaCards
    dermatomycosis    chronic monocytic leukemia    basilar artery occlusion    monocytic leukemia
    spinal cord injury    leukemia    breast cancer    neuronitis
    prostate cancer    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for RGMB:
    Dermatomycosis     Chronic monocytic leukemia

    RGMB for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: RGMB (1 document)

    Export disorders for RGMB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGMB gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with RGMB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. (PubMed id 19324014)1, 2, 3 Liu X.... Yamashita T. (Biochem. Biophys. Res. Commun. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub. (PubMed id 23744777)1 Bell C.H....Siebold C. (Science 2013)
    5. Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling. (PubMed id 22415859)1 Li J....Jiang W.G. (J. Cell. Biochem. 2012)
    6. Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells. (PubMed id 22076499)1 Li J....Jiang W.G. (Int. J. Oncol. 2012)
    7. Potential prognostic value of repulsive guidance molecules in breast cancer. (PubMed id 21617229)1 Li J....Jiang W.G. (Anticancer Res. 2011)
    8. Variants in several genomic regions associated with asperger disorder. (PubMed id 21182207)1 Salyakina D....Pericak-Vance M.A. (Autism Res 2010)
    9. DRAGON, a bone morphogenetic protein co-receptor. (PubMed id 15671031)1 Samad T.A....Woolf C.J. (J. Biol. Chem. 2005)
    10. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285704 HGNC: 26896 AceView: RGMB Ensembl:ENSG00000174136 euGenes: HUgn285704
    ECgene: RGMB H-InvDB: RGMB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGMB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGMB gene:
    Search GeneIP for patents involving RGMB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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