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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGMA Gene

protein-coding   GIFtS: 59
GCID: GC15M093586

RGM Domain Family, Member A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RGM Domain Family, Member A1 2
RGM2 3
Repulsive Guidance Molecule A2
RGM Domain Family Member A3

External Ids:    HGNC: 303081   Entrez Gene: 569632   Ensembl: ENSG000001821757   OMIM: 6073625   UniProtKB: Q96B863   

Export aliases for RGMA gene to outside databases

Previous GC identifers: GC15M091173 GC15M091316 GC15M091387 GC15M069723


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGMA Gene:
This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a
glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing
and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate
splicing results in multiple transcript variants. (provided by RefSeq, Oct 2009)

GeneCards Summary for RGMA Gene: 
RGMA (RGM domain family, member A) is a protein-coding gene. Diseases associated with RGMA include gastric ulcer, and hodgkin's lymphoma, and among its related super-pathways are Axon guidance and DCC mediated attractive signaling. An important paralog of this gene is RGMB.

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86
Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing
and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron
branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of
RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the
neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS
inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)
coreceptor that may signal through SMAD1, SMAD5, and SMAD8

Gene Wiki entry for RGMA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGMA gene promoter:
         GR   STAT1   AML1a   p53   GR-beta   STAT1beta   Nkx2-5   STAT1alpha   Ik-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGMA promoter sequence
   Search SABiosciences Chromatin IP Primers for RGMA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGMA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

RGMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGMA gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M093586:  view genomic region     (about GC identifiers)

Start:
93,586,636 bp from pter      End:
93,632,443 bp from pter
Size:
45,808 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86 (See protein sequence)
Recommended Name: Repulsive guidance molecule A precursor  
Size: 450 amino acids; 49347 Da
Subunit: Interacts with NEO1, BMP2 and BMP4 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
Secondary accessions: B2RTW1 Q0JV97 Q8NC80 Q9H0E6 Q9NPM3
Alternative splicing: 2 isoforms:  Q96B86-1   Q96B86-2   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGMA: NX_Q96B86

Explore proteomics data for RGMA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96B86

  • RGMA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGMA Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001159755.1  NP_001159758.1  NP_001159759.1  NP_001159760.1  NP_001159761.1  NP_064596.2  

    ENSEMBL proteins: 
     ENSP00000330005   ENSP00000440025   ENSP00000451505   ENSP00000452126   ENSP00000452170  
     ENSP00000456290   ENSP00000455634   ENSP00000451709   ENSP00000452350   ENSP00000442498  
     ENSP00000404442   ENSP00000442546  
    Reactome Protein details: Q96B86
    Human Recombinant Protein Products for RGMA: 
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    Novus Biologicals RGMA Protein
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    Sino Biological Recombinant Protein for RGMA
    Sino Biological Cell Lysate for RGMA 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RGMA 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0031225anchored to membrane IEA--

    RGMA for ontologies           About GeneDecksing



    RGMA Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for RGMA 

    Assay Products for RGMA: 
    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009496 RGM_C
     IPR010536 RGM_N

    Graphical View of Domain Structure for InterPro Entry Q96B86

    ProtoNet protein and cluster: Q96B86

    1 Blocks protein domain: IPB009496 Repulsive guidance molecule

    UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86
    Similarity: Belongs to the repulsive guidance molecule (RGM) family


    RGMA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGMA_HUMAN, Q96B86
    Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing
    and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron
    branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of
    RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the
    neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS
    inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)
    coreceptor that may signal through SMAD1, SMAD5, and SMAD8

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0015026coreceptor activity ----
         
    RGMA for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgma):
     craniofacial  embryogenesis  mortality/aging  nervous system  skeleton 

    RGMA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rgmatm1Arbr for RGMA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGMA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGMA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGMA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGMA 

    miRNA
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    hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRGMA 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of RGMA 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGMA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    2Netrin-1 signaling
    Netrin-1 signaling0.33
    3Signaling by BMP
    BMP receptor signaling0.31
    4Spinal Cord Injury
    Spinal Cord Injury

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RGMA
        Spinal Cord Injury
    BMP receptor signaling


    3        Reactome Pathways for RGMA
        Developmental Biology
    Netrin-1 signaling
    Axon guidance



    RGMA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGMA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for RGMA (Q96B862, 3 ENSP000003300054) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R16AQ96I342, 3MINT-65185 I2D: score=5 
    SGSM2O431472, 3MINT-64871 I2D: score=5 
    AHSGENSP000003938874STRING: ENSP00000393887
    BAMBIENSP000003646834STRING: ENSP00000364683
    BMP2ENSP000003681044STRING: ENSP00000368104
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ----
    GO:0007411axon guidance TAS--
    GO:0030509BMP signaling pathway ----
    GO:0030510regulation of BMP signaling pathway ----

    RGMA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGMA

    Search CenterWatch for drugs/clinical trials and news about RGMA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGMA gene (6 alternative transcripts): 
    NM_001166283.1  NM_001166286.1  NM_001166287.1  NM_001166288.1  NM_001166289.1  NM_020211.2  

    Unigene Cluster for RGMA:

    RGM domain family, member A
    Hs.271277  [show with all ESTs]
    Unigene Representative Sequence: AK125047
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329082(uc002bss.2) ENST00000542321(uc002bsq.2) ENST00000554387
    ENST00000557301 ENST00000557420 ENST00000556658 ENST00000556087 ENST00000555584
    ENST00000555598 ENST00000557608 ENST00000556950 ENST00000543599(uc021svu.1)
    ENST00000425933(uc021svs.1 uc021svt.1 uc010urc.2) ENST00000538818(uc010boi.2 uc002bsr.2)

    miRNA
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    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate RGMA (see all 65):
    hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRGMA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMA
    Sirion Biotech Customized lentivirus for stable overexpression of RGMA 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMA

    Additional mRNA sequence: 

    AK074910.1 AK074966.1 AK074980.1 AK125047.1 AK125204.1 AK291365.1 AK299363.1 AK309814.1 
    AL136826.1 AL390083.1 BC015886.1 BC127826.1 BC140838.1 BC151132.1 

    14 DOTS entries:

    DT.115395  DT.91678544  DT.91895498  DT.121072991  DT.121073001  DT.121072978  DT.121073005  DT.121072969 
    DT.121072976  DT.121072984  DT.121072997  DT.75103741  DT.95218133  DT.97841692 

    24/113 AceView cDNA sequences (see all 113):

    AI611126 CD514254 BF941898 BF059155 AI673327 AW172788 CN479256 AI982513 
    AW410706 CK821199 BI962598 BM703696 BF529098 AI801457 BC015886 BM805742 
    BI822323 AL390083 BQ446865 BE294286 BI916507 AK074980 BM467742 BM717591 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RGMA (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8
    SP1:                                -     -     -                 -                                             
    SP2:        -     -     -     -     -     -     -                 -                                             
    SP3:              -     -     -     -     -     -           -     -                                             
    SP4:                                -     -     -           -     -                                             
    SP5:                                      -     -           -     -                                             


    ECgene alternative splicing isoforms for RGMA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGMA expression in normal human tissues (normalized intensities)      RGMA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACCTGGC
    RGMA Expression
    About this image


    RGMA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Adipose (Muscoskeletal System)
             epididymal fat pads   
     
     Brain (Nervous System)
             ganglion/cranial/vestibulocochlear VIII   
     
     Oral Cavity (Gastrointestinal Tract)
             mouth   

    See RGMA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGMA

    SOURCE GeneReport for Unigene cluster: Hs.271277
        SABiosciences Expression via Pathway-Focused PCR Array including RGMA: 
              Stem Cell Signaling in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGMA gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgma1 , 5 RGM domain family, member A1, 5 88.51(n)1
    93.2(a)1
      7 (41.85 cM)5
    2440581  NM_177740.51  NP_808408.21 
     733755205 
    chicken
    (Gallus gallus)
    Aves RGMA1 RGM domain family, member A 82.76(n)
    86.14(a)
      395214  NM_204537.1  NP_989868.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGMA6
    RGM domain family, member A
    72(a)
    1 ↔ 1
    GL343392.1(947511-1006031)
    African clawed frog
    (Xenopus laevis)
    Amphibia rgma-prov2 repulsive guidance molecule A 80.27(n)    BC045008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb36g112 wufb36g11 74.13(n)   321842  BC054682.1 
    worm
    (Caenorhabditis elegans)
    Secernentea drag-16
    Protein DRAG-1
    22(a)
    1 → many
    I(1680450-1685063)


    ENSEMBL Gene Tree for RGMA (if available)
    TreeFam Gene Tree for RGMA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGMA gene
    RGMB2  HFE22  
    3 SIMAP similar genes for RGMA using alignment to 10 protein entries:     RGMA_HUMAN (see all proteins):
    YBX2    RGMB    HFE2

    RGMA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1314 SNPs in RGMA are shown (see all 1314)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0621444
    ----see VAR_0621442 D E mis40--------
    rs1492114431,2
    C--73356350(+) CCCCAC/TCCTCT 1 -- us2k10--------
    rs2012970721,2
    C--73356357(+) CTCTA-/GGGAGT 1 -- us2k10--------
    rs1433971691,2
    C--73356382(+) CTTTCC/GTTCCT 1 -- us2k10--------
    rs47780991,2
    C,F,A,H--73356903(+) GCCGTG/AAAGTG 1 -- us2k131Minor allele frequency- A:0.32NS EA NA WA 3196
    rs1164073711,2
    C,F--73356905(+) CGTGAA/GGTGTG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs734603601,2
    C,F--73357065(+) GAGTTT/CAAAAA 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs124421441,2
    C,F,A,H--93586217(+) ACCACA/GTAGTC 6 -- ds500123Minor allele frequency- G:0.31NA NS EA CSA 2346
    rs1380950561,2
    C--93586217(+) ACCAC-/ATAGTCA 6 -- ds50010--------
    rs753293701,2
    C--93586218(+) CCACA-/TAGTCAC 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for RGMA (93586636 - 93632443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RGMA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523617CNV Loss19592680
    nsv833096CNV Loss17160897
    dgv2437n71CNV Loss21882294
    dgv157n21CNV Loss19592680


    Human Gene Mutation Database (HGMD): RGMA
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RGMA
    DNA2.0 Custom Variant and Variant Library Synthesis for RGMA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607362    OMIM disorders: --

    7 diseases for RGMA:    About MalaCards
    gastric ulcer    hodgkin's lymphoma    multiple sclerosis    colon cancer
    colorectal cancer    breast cancer    neuronitis


    RGMA for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGMA
    Human Genome Epidemiology (HuGE) Navigator: RGMA (2 documents)

    Export disorders for RGMA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGMA gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with RGMA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. RGMA and IL21R show association with experimental inf lammation and multiple sclerosis. (PubMed id 20072140)1, 4 Nohra R....Olsson T. (2010)
    3. Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. (PubMed id 19458235)1, 2 Endo M. and Yamashita T. (2009)
    4. Unc5B associates with LARG to mediate the action of repulsive guidance molecule. (PubMed id 19273616)1, 2 Hata K.... Yamashita T. (2009)
    5. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)1, 4 Verma R....Levinson D.F. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PubMed id 17472960)1, 9 Xia Y....Lin H.Y. (2007)
    9. Emerging roles for neogenin and its ligands in CNS development. (PubMed id 18485097)1, 9 De Vries M. and Cooper H.M. (2008)
    10. Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of pr ostate cancer cells. (PubMed id 22076499)1 Li J....Jiang W.G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56963 HGNC: 30308 AceView: RGMA Ensembl:ENSG00000182175 euGenes: HUgn56963
    ECgene: RGMA H-InvDB: RGMA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGMA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGMA gene:
    Search GeneIP for patents involving RGMA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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