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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGMA Gene

protein-coding GIFtS: 56
GCID: GC15M093586

RGM domain family, member A

Explore 6 diseases affiliated with
RGMA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RGM Domain Family, Member A¹ ²
RGM¹ ² ³
Repulsive Guidance Molecule A²
RGM Domain Family Member A³

External Ids:	HGNC: 30308¹	Entrez Gene: 56963²	Ensembl: ENSG00000182175⁷	OMIM: 607362⁵	UniProtKB: Q96B86³

Export aliases for RGMA gene to outside databases

Previous GC identifers: GC15M091173 GC15M091316 GC15M091387 GC15M069723

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGMA:

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a

glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and

adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing

results in multiple transcript variants. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86

Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and

adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron

branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of

RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the

neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS

inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)

coreceptor that may signal through SMAD1, SMAD5, and SMAD8

Gene Wiki entry for RGMA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGMA gene promoter:
GR STAT1 AML1a p53 GR-beta STAT1beta Nkx2-5 STAT1alpha Ik-2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGMA promoter sequence

Search SABiosciences Chromatin IP Primers for RGMA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGMA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1

RGMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGMA gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M093586: view genomic region (about GC identifiers)

Start:	93,586,636 bp from pter	End:	93,632,443 bp from pter
Size:	45,808 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86 (See protein sequence)

Recommended Name: Repulsive guidance molecule A precursor

Size: 450 amino acids; 49347 Da

Subunit: Interacts with NEO1, BMP2 and BMP4 (By similarity)

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)

Secondary accessions: B2RTW1 Q0JV97 Q8NC80 Q9H0E6 Q9NPM3

Alternative splicing: 2 isoforms: Q96B86-1 Q96B86-2 (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGMA: NX_Q96B86

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96B86

RGMA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001159755.1 NP_001159758.1 NP_001159759.1 NP_001159760.1 NP_001159761.1 NP_064596.2

ENSEMBL proteins:

ENSP00000330005 ENSP00000440025 ENSP00000451505 ENSP00000452126 ENSP00000452170

ENSP00000456290 ENSP00000455634 ENSP00000451709 ENSP00000452350 ENSP00000442498

ENSP00000404442 ENSP00000442546

Reactome Protein details: Q96B86
Human Recombinant Protein Products for RGMA:

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	Novus Biologicals RGMA Protein Novus Biologicals RGMA Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RGMA

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	--	--
GO:0031225	anchored to membrane	IEA	--

RGMA for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RGMA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGMA for domains About GeneDecksing

2 InterPro domains/families:

IPR009496 RGM_C

IPR010536 RGM_N

Graphical View of Domain Structure for InterPro Entry Q96B86

ProtoNet protein and cluster: Q96B86

1 Blocks protein family: IPB009496 Repulsive guidance molecule

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86

Similarity: Belongs to the repulsive guidance molecule (RGM) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RGMA_HUMAN, Q96B86

Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and

adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron

branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of

RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the

neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS

inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)

coreceptor that may signal through SMAD1, SMAD5, and SMAD8

Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rgma):

craniofacial

embryogenesis

mortality/aging

nervous system

skeleton

RGMA for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Rgma^tm1Arbr for RGMA

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RGMA

miRNA Products:		OriGene 3'-UTR Clone: RGMA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGMA
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate RGMA (see all 65):
		hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: RGMA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGMA (see all 7) OriGene shRNA RFP: RGMA OriGene siRNA: RGMA
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		Sirion Biotech Custom design and validation of potent shRNA sequences against RGMA

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RGMA
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGMA (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGMA (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): RGMA (NM_020211)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Netrin-1 signaling

Netrin-1 signaling

1.00

Signaling by BMP

BMP receptor signaling

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for RGMA

BMP receptor signaling

3 Reactome Pathways for RGMA

	Developmental Biology
	Netrin-1 signaling
	Axon guidance

RGMA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RGMA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for RGMA (Q96B86^{2, 3} ENSP00000330005⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1R16A	Q96I34²^,³	MINT-65185 I2D: score=5
SGSM2	O43147²^,³	MINT-64871 I2D: score=5
AHSG	ENSP00000393887⁴	STRING: ENSP00000393887
BAMBI	ENSP00000364683⁴	STRING: ENSP00000364683
BMP2	ENSP00000368104⁴	STRING: ENSP00000368104

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001843	neural tube closure	--	--
GO:0007411	axon guidance	TAS	--
GO:0030510	regulation of BMP signaling pathway	--	--

RGMA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGMA
Search CenterWatch for drugs/clinical trials and news about RGMA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGMA gene (6 alternative transcripts):

NM_001166283.1 NM_001166286.1 NM_001166287.1 NM_001166288.1 NM_001166289.1 NM_020211.2

Unigene Cluster for RGMA:

RGM domain family, member A

Hs.271277 [show with all ESTs]

Unigene Representative Sequence: AK125047

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000329082(uc002bss.2) ENST00000542321(uc002bsq.2) ENST00000554387

ENST00000557301 ENST00000557420 ENST00000556658 ENST00000556087 ENST00000555584

ENST00000555598 ENST00000557608 ENST00000556950 ENST00000543599(uc021svu.1)

ENST00000425933(uc021svs.1 uc021svt.1 uc010urc.2) ENST00000538818(uc010boi.2 uc002bsr.2)

miRNA Products:		OriGene 3'-UTR Clone: RGMA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGMA
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate RGMA (see all 65):
		hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: RGMA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against RGMA

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		GenScript: all cDNA clones in your preferred vector (see all 6): RGMA (NM_020211)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGMA Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMA

Additional cDNA sequence:

AK074910.1 AK074966.1 AK074980.1 AK125047.1 AK125204.1 AK291365.1 AK299363.1 AK309814.1

AL136826.1 AL390083.1 BC015886.1 BC127826.1 BC140838.1 BC151132.1

14 DOTS entries:

DT.115395 DT.91678544 DT.91895498 DT.121072991 DT.121073001 DT.121072978 DT.121073005 DT.121072969

DT.121072976 DT.121072984 DT.121072997 DT.75103741 DT.95218133 DT.97841692

24/113 AceView cDNA sequences (see all 113):

BF941898 BF059155 AI611126 CD514254 AI673327 AK074910 BI917750 BF306472

AI678354 AI889197 BC015886 AI748798 AA394113 AI147283 AI419313 AK125047

BM922212 AA179952 F04685 BI754721 BI962701 AW071781 BI821283 AI270491

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RGMA (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8
SP1:											-		-		-						-
SP2:			-		-		-		-		-		-		-						-
SP3:					-		-		-		-		-		-				-		-
SP4:											-		-		-				-		-
SP5:													-		-				-		-

ECgene alternative splicing isoforms for RGMA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGMA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCACCTGGC

About this image

RGMA expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Spinal Dorsal Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

Definitive endoderm-like cells (A scalable, suspensi...)

See RGMA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGMA

SOURCE GeneReport for Unigene cluster: Hs.271277

SABiosciences Expression via Pathway-Focused PCR Array including RGMA:

Stem Cell Signaling in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RGMA gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RGMA¹	RGM domain family, member A	82.76(n) 86.14(a)		395214 NM_204537.1 NP_989868.1
lizard (Anolis carolinensis)	Reptilia	RGMA⁶	--	71(a)	1 ↔ 1	GL343392.1(951747-955104)
African clawed frog (Xenopus laevis)	Amphibia	rgma-prov²	repulsive guidance molecule A	80.27(n)		BC045008.1
zebrafish (Danio rerio)	Actinopterygii	wufb36g11²	wufb36g11	74.13(n)		321842 BC054682.1
worm (Caenorhabditis elegans)	Secernentea	drag-1⁶	DRAG-1; Protein DRAG-1	24(a)	1 → many	I(1680452-1685065)

ENSEMBL Gene Tree for RGMA (if available)
TreeFam Gene Tree for RGMA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RGMA gene

RGMB² HFE2²

2 SIMAP similar genes for RGMA using alignment to 10 protein entries: RGMA_HUMAN (see all proteins):

RGMB HFE2

RGMA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12442144^1,2	C,F,A,H	--	93586217(+)	`ACCACA/GTAGTC`	6	--	ds500¹		23		NA NS EA CSA	2346
rs138095056^1,2	C	--	93586217(+)	`ACCAC-/ATAGTCA`	6	--	ds500¹		0	--	--	--	--
rs139697053^1,2		--	93586237(+)	`CCTGAA/CTGTGT`	6	--	ds500¹		0	--	--	--	--
rs144462821^1,2		--	93586251(+)	`ACTGTC/TACTAG`	6	--	ds500¹		0	--	--	--	--
rs181806153^1,2		--	93586258(+)	`CTAGAA/TCAAGA`	6	--	ds500¹		0	--	--	--	--
rs17649077^1,2	C,F,H	--	93586296(+)	`CAGCTC/TATCGT`	6	--	ds500¹		23		NA NS EA CSA WA	2506
rs184369858^1,2		--	93586299(+)	`CTCATC/TGTGAG`	6	--	ds500¹		0	--	--	--	--
rs189648729^1,2		--	93586302(+)	`ATCGTA/GAGGAG`	6	--	ds500¹		0	--	--	--	--
rs145402482^1,2		--	93586337(+)	`GTGTGA/GTGGCT`	6	--	ds500¹		0	--	--	--	--
rs148809629^1,2		--	93586366(+)	`CTATCC/TGCCTT`	6	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RGMA (93586636 - 93632443 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RGMA: --
Human Gene Mutation Database (HGMD): RGMA

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RGMA for disorders           About GeneDecksing

OMIM gene information: 607362    OMIM disorders: --

6 diseases for RGMA:    About MalaCards

hodgkin's lymphoma gastric ulcer multiple sclerosis colon cancer

breast cancer neuronitis

Human Genome Epidemiology (HuGE) Navigator: RGMA (2 documents)

Export disorders for RGMA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RGMA gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with RGMA)

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Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. (PubMed id 19458235)^{1, 2} Endo M. and Yamashita T. (2009)
Unc5B associates with LARG to mediate the action of repulsive guidance molecule. (PubMed id 19273616)^{1, 2} Hata K.... Yamashita T. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PubMed id 17472960)^{1, 9} Xia Y....Lin H.Y. (2007)
Emerging roles for neogenin and its ligands in CNS development. (PubMed id 18485097)^{1, 9} De Vries M. and Cooper H.M. (2008)
Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of pr ostate cancer cells. (PubMed id 22076499)¹ Li J....Jiang W.G. (2012)
Decreased expression of repulsive guidance molecule me mber A by DNA methylation in colorectal cancer is related to tumor progression. (PubMed id 22367090)¹ Zhao Z.W....Hou Y.P. (2012)
Identification of the neogenin-binding site on the rep ulsive guidance molecule A. (PubMed id 22396795)¹ Itokazu T....Yamashita T. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56963	HGNC: 30308	AceView: RGMA	Ensembl:ENSG00000182175	euGenes: HUgn56963
ECgene: RGMA	H-InvDB: RGMA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RGMA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RGMA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RGMA gene:
Search GeneIP for patents involving RGMA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RGM domain family, member A

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RGM domain family, member A

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