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RGMA Gene

protein-coding   GIFtS: 60
GCID: GC15M093586

Repulsive Guidance Molecule Family Member A

(Previous names: RGM domain family, member A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Repulsive Guidance Molecule Family Member A1 2
RGM Domain Family, Member A1 2
RGM2 3
Repulsive Guidance Molecule A2
RGM Domain Family Member A3

External Ids:    HGNC: 303081   Entrez Gene: 569632   Ensembl: ENSG000001821757   OMIM: 6073625   UniProtKB: Q96B863   

Export aliases for RGMA gene to outside databases

Previous GC identifers: GC15M091173 GC15M091316 GC15M091387 GC15M069723


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGMA Gene:
This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a
glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing
and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate
splicing results in multiple transcript variants. (provided by RefSeq, Oct 2009)

GeneCards Summary for RGMA Gene:
RGMA (repulsive guidance molecule family member a) is a protein-coding gene. An important paralog of this gene is RGMB.

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86
Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing
and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron
branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of
RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the
neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS
inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)
coreceptor that may signal through SMAD1, SMAD5, and SMAD8

Gene Wiki entry for RGMA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGMA gene promoter:
         GR   STAT1   AML1a   p53   GR-beta   STAT1beta   Nkx2-5   STAT1alpha   Ik-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGMA promoter sequence
   Search Chromatin IP Primers for RGMA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGMA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

RGMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGMA gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M093586:  view genomic region     (about GC identifiers)

Start:
93,586,636 bp from pter      End:
93,632,443 bp from pter
Size:
45,808 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86 (See protein sequence)
Recommended Name: Repulsive guidance molecule A precursor  
Size: 450 amino acids; 49347 Da
Subunit: Interacts with NEO1, BMP2 and BMP4 (By similarity)
Secondary accessions: B2RTW1 Q0JV97 Q8NC80 Q9H0E6 Q9NPM3
Alternative splicing: 2 isoforms:  Q96B86-1   Q96B86-2   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGMA: NX_Q96B86

Explore proteomics data for RGMA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn114, Asn159, Asn389
  • Modification sites at PhosphoSitePlus

  • See RGMA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001159755.1  NP_001159758.1  NP_001159759.1  NP_001159760.1  NP_001159761.1  NP_064596.2  

    ENSEMBL proteins: 
     ENSP00000330005   ENSP00000440025   ENSP00000451505   ENSP00000452126   ENSP00000452170  
     ENSP00000456290   ENSP00000455634   ENSP00000451709   ENSP00000452350   ENSP00000442498  
     ENSP00000404442   ENSP00000442546  
    Reactome Protein details: Q96B86

    RGMA Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RGMA
    OriGene MassSpec for RGMA
    OriGene Custom Protein Services for RGMA
    GenScript Custom Purified and Recombinant Proteins Services for RGMA
    Novus Biologicals RGMA Protein
    Novus Biologicals RGMA Lysates
    Sino Biological Recombinant Protein for RGMA
    Sino Biological Cell Lysate for RGMA
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RGMA

     
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    antibodies-online proteins for RGMA (10 products) 

     
    antibodies-online peptides for RGMA

    RGMA Antibody Products:

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    LSBio Antibodies in human, mouse, rat for RGMA
    antibodies-online antibodies for RGMA (29 products) 

    RGMA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RGMA
    Cloud-Clone Corp. CLIAs for RGMA
    Search eBioscience for ELISAs for RGMA 
    antibodies-online kits for RGMA (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009496 RGM_C
     IPR010536 RGM_N

    Graphical View of Domain Structure for InterPro Entry Q96B86

    ProtoNet protein and cluster: Q96B86

    1 Blocks protein domain: IPB009496 Repulsive guidance molecule

    UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86
    Similarity: Belongs to the repulsive guidance molecule (RGM) family


    Find genes that share domains with RGMA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGMA_HUMAN, Q96B86
    Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing
    and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron
    branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of
    RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the
    neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS
    inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)
    coreceptor that may signal through SMAD1, SMAD5, and SMAD8

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0015026coreceptor activity ----
         
    Find genes that share ontologies with RGMA           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgma):
     craniofacial  embryogenesis  mortality/aging  nervous system  skeleton 

    Find genes that share phenotypes with RGMA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgmatm1Arbr for RGMA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGMA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGMA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGMA

    miRNA
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    miRTarBase miRNAs that target RGMA:
    hsa-mir-148b-3p (MIRT019379), hsa-mir-615-3p (MIRT040467)

    Block miRNA regulation of human, mouse, rat RGMA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGMA (see all 65):
    hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRGMA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RGMA
    Predesigned siRNA for gene silencing in human, mouse, rat RGMA

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): RGMA (NM_020211)
    Sino Biological Human cDNA Clone for RGMA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMA

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGMA_HUMAN, Q96B86: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    mitochondrion2
    cytosol1
    extracellular1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with RGMA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGMA About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Signaling by BMP
    BMP receptor signaling0.31
    3Spinal Cord Injury
    Spinal Cord Injury
    4Netrin-1 signaling
    Netrin-1 signaling


    Find genes that share SuperPaths with RGMA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RGMA
        Spinal Cord Injury
    BMP receptor signaling


    1 Reactome Pathway for RGMA
        Netrin-1 signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including RGMA: 
              Stem Cell Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RGMA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGMA (Q96B862, 3 ENSP000003300054) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R16AQ96I342, 3MINT-65185 I2D: score=5 
    SGSM2O431472, 3MINT-64871 I2D: score=5 
    AHSGENSP000003938874STRING: ENSP00000393887
    BAMBIENSP000003646834STRING: ENSP00000364683
    BMP2ENSP000003681044STRING: ENSP00000368104
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ----
    GO:0007411axon guidance TAS--
    GO:0030509BMP signaling pathway ----
    GO:0030510regulation of BMP signaling pathway ----

    Find genes that share ontologies with RGMA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGMA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGMA gene (6 alternative transcripts): 
    NM_001166283.1  NM_001166286.1  NM_001166287.1  NM_001166288.1  NM_001166289.1  NM_020211.2  

    Unigene Cluster for RGMA:

    RGM domain family, member A
    Hs.271277  [show with all ESTs]
    Unigene Representative Sequence: AK125047
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329082(uc002bss.2) ENST00000542321(uc002bsq.2) ENST00000554387
    ENST00000557301 ENST00000557420 ENST00000556658 ENST00000556087 ENST00000555584
    ENST00000555598 ENST00000557608 ENST00000556950 ENST00000543599(uc021svu.1)
    ENST00000425933(uc021svs.1 uc021svt.1 uc010urc.2) ENST00000538818(uc010boi.2 uc002bsr.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat RGMA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGMA (see all 65):
    hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRGMA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RGMA
    Predesigned siRNA for gene silencing in human, mouse, rat RGMA
    Clone
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    OriGene ORF clones in mouse, rat for RGMA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): RGMA (NM_020211)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RGMA
    OriGene qSTAR qPCR primer pairs in human, mouse for RGMA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGMA
      QuantiTect SYBR Green Assays in human, mouse, rat RGMA
      QuantiFast Probe-based Assays in human, mouse, rat RGMA

    Additional mRNA sequence: 

    AK074910.1 AK074966.1 AK074980.1 AK125047.1 AK125204.1 AK291365.1 AK299363.1 AK309814.1 
    AL136826.1 AL390083.1 BC015886.1 BC127826.1 BC140838.1 BC151132.1 

    14 DOTS entries:

    DT.115395  DT.91678544  DT.91895498  DT.121072991  DT.121073001  DT.121072978  DT.121073005  DT.121072969 
    DT.121072976  DT.121072984  DT.121072997  DT.75103741  DT.95218133  DT.97841692 

    Selected AceView cDNA sequences (see all 113):

    AI611126 CD514254 BF941898 BF059155 AI673327 BI917750 AW172788 CN479256 
    AI982513 AW410706 CK821199 BI962598 BM703696 BF529098 AI801457 BC015886 
    BM805742 BI822323 AL390083 BQ446865 BE294286 BI916507 AK074980 BM467742 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RGMA (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8
    SP1:                                -     -     -                 -                                             
    SP2:        -     -     -     -     -     -     -                 -                                             
    SP3:              -     -     -     -     -     -           -     -                                             
    SP4:                                -     -     -           -     -                                             
    SP5:                                      -     -           -     -                                             


    ECgene alternative splicing isoforms for RGMA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGMA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACCTGGC
    RGMA Expression
    About this image


    RGMA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
    RGMA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGMA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271277
        Pathway & Disease-focused RT2 Profiler PCR Array including RGMA: 
              Stem Cell Signaling in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RGMA
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    QuantiFast Probe-based Assays in human, mouse, rat RGMA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGMA gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgma1 , 5 RGM domain family, member A5
    repulsive guidance molecule family member A1
    89.1(n)1
    93.97(a)1
      7 (41.85 cM)5
    2440581  NM_177740.51  NP_808408.21 
     733755205 
    chicken
    (Gallus gallus)
    Aves RGMA1 RGM domain family, member A 82.22(n)
    84.94(a)
      395214  NM_204537.1  NP_989868.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGMA6
    repulsive guidance molecule family member a
    71(a)
    1 ↔ 1
    GL343392.1(947511-1006031)
    African clawed frog
    (Xenopus laevis)
    Amphibia rgma-prov2 repulsive guidance molecule A 80.27(n)    BC045008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb36g112 wufb36g11 74.13(n)   321842  BC054682.1 
    worm
    (Caenorhabditis elegans)
    Secernentea drag-16
    Protein DRAG-1 (drag-1) mRNA, complete cds
    25(a)
    1 → many
    I(1680450-1685063) WBGene00022154


    ENSEMBL Gene Tree for RGMA (if available)
    TreeFam Gene Tree for RGMA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGMA gene
    RGMB2  HFE22  
    3 SIMAP similar genes for RGMA using alignment to 10 protein entries:     RGMA_HUMAN (see all proteins):
    YBX2    RGMB    HFE2

    Find genes that share paralogs with RGMA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGMA (see all 1314)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492114431,2
    C--73356350(+) CCCCAC/TCCTCT 1 -- us2k10--------
    rs2012970721,2
    C--73356357(+) CTCTA-/GGGAGT 1 -- us2k10--------
    rs1433971691,2
    C--73356382(+) CTTTCC/GTTCCT 1 -- us2k10--------
    rs47780991,2
    C,F,A,H--73356903(+) GCCGTG/AAAGTG 1 -- us2k131Minor allele frequency- A:0.32NS EA NA WA 3196
    rs1164073711,2
    C,F--73356905(+) CGTGAA/GGTGTG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs734603601,2
    C,F--73357065(+) GAGTTT/CAAAAA 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs124421441,2
    C,F,A,H--93586217(+) ACCACA/GTAGTC 6 -- ds500123Minor allele frequency- G:0.31NA NS EA CSA 2346
    rs1380950561,2
    C--93586217(+) ACCAC-/ATAGTCA 6 -- ds50010--------
    rs753293701,2
    C--93586218(+) CCACA-/TAGTCAC 6 -- ds50010--------
    rs1396970531,2
    --93586237(+) CCTGAA/CTGTGT 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for RGMA (93586636 - 93632443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RGMA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523617CNV Loss19592680
    nsv833096CNV Loss17160897
    dgv2437n71CNV Loss21882294
    dgv157n21CNV Loss19592680

    Human Gene Mutation Database (HGMD): RGMA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGMA
    DNA2.0 Custom Variant and Variant Library Synthesis for RGMA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607362    OMIM disorders: --


    Find genes that share disorders with RGMA           About GenesLikeMe

    Genetic Association Database (GAD): RGMA
    Human Genome Epidemiology (HuGE) Navigator: RGMA (2 documents)

    Export disorders for RGMA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGMA gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with RGMA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. (PubMed id 20072140)1, 4 Nohra R....Olsson T. (Genes Immun. 2010)
    2. Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. (PubMed id 19458235)1, 2 Endo M. and Yamashita T. (J. Neurosci. 2009)
    3. Unc5B associates with LARG to mediate the action of repulsive guidance molecule. (PubMed id 19273616)1, 2 Hata K.... Yamashita T. (J. Cell Biol. 2009)
    4. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)1, 4 Verma R....Levinson D.F. (Biol. Psychiatry 2008)
    5. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. (PubMed id 15975920)1, 3 Babitt J.L....Lin H.Y. (J. Biol. Chem. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PubMed id 17472960)1, 9 Xia Y....Lin H.Y. (J. Biol. Chem. 2007)
    10. Emerging roles for neogenin and its ligands in CNS development. (PubMed id 18485097)1, 9 De Vries M. and Cooper H.M. (J. Neurochem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56963 HGNC: 30308 AceView: RGMA Ensembl:ENSG00000182175 euGenes: HUgn56963
    ECgene: RGMA H-InvDB: RGMA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGMA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGMA gene:
    Search GeneIP for patents involving RGMA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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