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Aliases for RGMA Gene

Aliases for RGMA Gene

  • Repulsive Guidance Molecule Family Member A 2 3
  • RGM Domain Family, Member A 2 3
  • RGM 3 4
  • RGM Domain Family Member A 4

External Ids for RGMA Gene

Previous GeneCards Identifiers for RGMA Gene

  • GC15M091173
  • GC15M091316
  • GC15M091387
  • GC15M093586
  • GC15M069723

Summaries for RGMA Gene

Entrez Gene Summary for RGMA Gene

  • This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for RGMA Gene

RGMA (Repulsive Guidance Molecule Family Member A) is a Protein Coding gene. Diseases associated with RGMA include actinomycosis and leukemia, acute myeloid. Among its related pathways are Developmental Biology and Spinal Cord Injury. GO annotations related to this gene include coreceptor activity. An important paralog of this gene is HFE2.

UniProtKB/Swiss-Prot for RGMA Gene

  • Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Gene Wiki entry for RGMA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGMA Gene

Genomics for RGMA Gene

Regulatory Elements for RGMA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGMA Gene

Chromosome:
15
Start:
93,035,273 bp from pter
End:
93,089,214 bp from pter
Size:
53,942 bases
Orientation:
Minus strand

Genomic View for RGMA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGMA Gene

Proteins for RGMA Gene

  • Protein details for RGMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B86-RGMA_HUMAN
    Recommended name:
    Repulsive guidance molecule A
    Protein Accession:
    Q96B86
    Secondary Accessions:
    • B2RTW1
    • B7Z5S8
    • F5GXQ7
    • F5GZU6
    • G3V518
    • Q0JV97
    • Q8NC80
    • Q9H0E6
    • Q9NPM3

    Protein attributes for RGMA Gene

    Size:
    450 amino acids
    Molecular mass:
    49347 Da
    Quaternary structure:
    • Interacts with NEO1, BMP2 and BMP4.
    SequenceCaution:
    • Sequence=AAH15886.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB98207.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGMA Gene

    Alternative splice isoforms for RGMA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGMA Gene

Proteomics data for RGMA Gene at MOPED

Post-translational modifications for RGMA Gene

  • Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.
  • Glycosylation at Asn 114, Asn 159, and Asn 389
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RGMA Gene

Domains & Families for RGMA Gene

Protein Domains for RGMA Gene

Suggested Antigen Peptide Sequences for RGMA Gene

Graphical View of Domain Structure for InterPro Entry

Q96B86

UniProtKB/Swiss-Prot:

RGMA_HUMAN :
  • Belongs to the repulsive guidance molecule (RGM) family.
Family:
  • Belongs to the repulsive guidance molecule (RGM) family.
genes like me logo Genes that share domains with RGMA: view

No data available for Gene Families for RGMA Gene

Function for RGMA Gene

Molecular function for RGMA Gene

UniProtKB/Swiss-Prot Function:
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Gene Ontology (GO) - Molecular Function for RGMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 22728873
GO:0005515 protein binding --
GO:0015026 coreceptor activity IBA --
GO:1990459 transferrin receptor binding IPI 22728873
genes like me logo Genes that share ontologies with RGMA: view
genes like me logo Genes that share phenotypes with RGMA: view

Animal Models for RGMA Gene

MGI Knock Outs for RGMA:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGMA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RGMA Gene

Localization for RGMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGMA Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGMA Gene COMPARTMENTS Subcellular localization image for RGMA gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 4
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RGMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane IBA --
GO:0009986 cell surface --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RGMA: view

Pathways & Interactions for RGMA Gene

genes like me logo Genes that share pathways with RGMA: view

Pathways by source for RGMA Gene

2 BioSystems pathways for RGMA Gene
3 Reactome pathways for RGMA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for RGMA Gene

Gene Ontology (GO) - Biological Process for RGMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure --
GO:0007411 axon guidance TAS --
GO:0030509 BMP signaling pathway IBA --
GO:0030510 regulation of BMP signaling pathway --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 22728873
genes like me logo Genes that share ontologies with RGMA: view

No data available for SIGNOR curated interactions for RGMA Gene

Drugs & Compounds for RGMA Gene

No Compound Related Data Available

Transcripts for RGMA Gene

Unigene Clusters for RGMA Gene

RGM domain family, member A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGMA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGMA Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8
SP1: - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7: - - -
SP8: - -

Relevant External Links for RGMA Gene

GeneLoc Exon Structure for
RGMA
ECgene alternative splicing isoforms for
RGMA

Expression for RGMA Gene

mRNA expression in normal human tissues for RGMA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGMA Gene

This gene is overexpressed in Muscle - Skeletal (x5.7) and Esophagus - Muscularis (x4.7).

Protein differential expression in normal tissues from HIPED for RGMA Gene

This gene is overexpressed in Fetal Brain (19.4), Testis (14.7), Frontal cortex (14.7), and Spinal cord (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGMA Gene



SOURCE GeneReport for Unigene cluster for RGMA Gene Hs.271277

genes like me logo Genes that share expression patterns with RGMA: view

Protein tissue co-expression partners for RGMA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGMA Gene

Orthologs for RGMA Gene

This gene was present in the common ancestor of animals.

Orthologs for RGMA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGMA 35
  • 91.73 (n)
  • 93.08 (a)
RGMA 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGMA 35
  • 91.93 (n)
  • 94.23 (a)
RGMA 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgma 35
  • 89.1 (n)
  • 93.97 (a)
Rgma 16
Rgma 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGMA 35
  • 99.63 (n)
  • 99.78 (a)
RGMA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgma 35
  • 89.53 (n)
  • 94.42 (a)
oppossum
(Monodelphis domestica)
Mammalia RGMA 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGMA 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGMA 35
  • 82.22 (n)
  • 84.94 (a)
RGMA 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGMA 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgma 35
  • 75.64 (n)
  • 78.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia rgma-prov 35
zebrafish
(Danio rerio)
Actinopterygii rgma 35
  • 68.71 (n)
  • 70.02 (a)
wufb36g11 35
rgma 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea drag-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for RGMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGMA Gene

ENSEMBL:
Gene Tree for RGMA (if available)
TreeFam:
Gene Tree for RGMA (if available)

Paralogs for RGMA Gene

Paralogs for RGMA Gene

genes like me logo Genes that share paralogs with RGMA: view

Variants for RGMA Gene

Sequence variations from dbSNP and Humsavar for RGMA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13167 -- 93,043,872(+) GGGCA(C/T)AGCAG utr-variant-3-prime
rs749611 -- 93,070,001(+) CCTTC(C/G)TAGGT intron-variant
rs997941 -- 93,083,603(+) GAATT(A/G)TAAAT intron-variant
rs1320818 -- 93,076,065(+) GCACT(C/G)CGTTC intron-variant
rs1534780 -- 93,081,984(+) AAGAA(C/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGMA Gene

Variant ID Type Subtype PubMed ID
dgv157n21 CNV Loss 19592680
dgv2437n71 CNV Loss 21882294
nsv523617 CNV Loss 19592680
nsv833096 CNV Loss 17160897

Variation tolerance for RGMA Gene

Residual Variation Intolerance Score: 44.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGMA Gene

HapMap Linkage Disequilibrium report
RGMA
Human Gene Mutation Database (HGMD)
RGMA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGMA Gene

Disorders for RGMA Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGMA Gene - From: DISEASES

Disorder Aliases PubMed IDs
actinomycosis
  • madura foot due to actinomadura
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association
Search RGMA in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGMA

Genetic Association Database (GAD)
RGMA
Human Genome Epidemiology (HuGE) Navigator
RGMA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGMA
genes like me logo Genes that share disorders with RGMA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGMA Gene

Publications for RGMA Gene

  1. Emerging roles for neogenin and its ligands in CNS development. (PMID: 18485097) De Vries M. … Cooper H.M. (J. Neurochem. 2008) 23 67
  2. Neogenin: A multi-functional receptor regulating diverse developmental processes. (PMID: 17204444) Cole S.J. … Cooper H.M. (Int. J. Biochem. Cell Biol. 2007) 23 67
  3. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PMID: 17472960) Xia Y. … Lin H.Y. (J. Biol. Chem. 2007) 23 67
  4. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. (PMID: 16604073) Babitt J.L. … Lin H.Y. (Nat. Genet. 2006) 23 67
  5. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. (PMID: 15975920) Babitt J.L. … Lin H.Y. (J. Biol. Chem. 2005) 2 67

Products for RGMA Gene

Sources for RGMA Gene

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