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Aliases for RGMA Gene

Aliases for RGMA Gene

  • Repulsive Guidance Molecule Family Member A 2 3
  • RGM Domain Family, Member A 2 3
  • RGM 3 4
  • Repulsive Guidance Molecule A 3
  • RGM Domain Family Member A 4

External Ids for RGMA Gene

Previous GeneCards Identifiers for RGMA Gene

  • GC15M091173
  • GC15M091316
  • GC15M091387
  • GC15M093586
  • GC15M069723

Summaries for RGMA Gene

Entrez Gene Summary for RGMA Gene

  • This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for RGMA Gene

RGMA (Repulsive Guidance Molecule Family Member A) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. An important paralog of this gene is HFE2.

UniProtKB/Swiss-Prot for RGMA Gene

  • Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Gene Wiki entry for RGMA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGMA Gene

Genomics for RGMA Gene

Regulatory Elements for RGMA Gene

Genomic Location for RGMA Gene

Start:
93,035,273 bp from pter
End:
93,089,214 bp from pter
Size:
53,942 bases
Orientation:
Minus strand

Genomic View for RGMA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGMA Gene

Proteins for RGMA Gene

  • Protein details for RGMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B86-RGMA_HUMAN
    Recommended name:
    Repulsive guidance molecule A
    Protein Accession:
    Q96B86
    Secondary Accessions:
    • B2RTW1
    • B7Z5S8
    • F5GXQ7
    • F5GZU6
    • G3V518
    • Q0JV97
    • Q8NC80
    • Q9H0E6
    • Q9NPM3

    Protein attributes for RGMA Gene

    Size:
    450 amino acids
    Molecular mass:
    49347 Da
    Quaternary structure:
    • Interacts with NEO1, BMP2 and BMP4.
    SequenceCaution:
    • Sequence=AAH15886.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB98207.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RGMA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGMA Gene

Proteomics data for RGMA Gene at MOPED

Post-translational modifications for RGMA Gene

  • Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.
  • Glycosylation at Asn114, Asn159, and Asn389
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RGMA Gene

Domains for RGMA Gene

Protein Domains for RGMA Gene

Suggested Antigen Peptide Sequences for RGMA Gene

Graphical View of Domain Structure for InterPro Entry

Q96B86

UniProtKB/Swiss-Prot:

RGMA_HUMAN :
  • Q96B86
Family:
  • Belongs to the repulsive guidance molecule (RGM) family.
genes like me logo Genes that share domains with RGMA: view

No data available for Gene Families for RGMA Gene

Function for RGMA Gene

Molecular function for RGMA Gene

UniProtKB/Swiss-Prot Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Gene Ontology (GO) - Molecular Function for RGMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0015026 coreceptor activity IBA --
genes like me logo Genes that share ontologies with RGMA: view
genes like me logo Genes that share phenotypes with RGMA: view

Animal Models for RGMA Gene

MGI Knock Outs for RGMA:

miRNA for RGMA Gene

miRTarBase miRNAs that target RGMA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RGMA Gene

Localization for RGMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGMA Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGMA Gene COMPARTMENTS Subcellular localization image for RGMA gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
mitochondrion 2
cytosol 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RGMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane IBA --
GO:0009986 cell surface --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RGMA: view

Pathways for RGMA Gene

genes like me logo Genes that share pathways with RGMA: view

Pathways by source for RGMA Gene

2 BioSystems pathways for RGMA Gene
3 Reactome pathways for RGMA Gene

Interacting Proteins for RGMA Gene

Gene Ontology (GO) - Biological Process for RGMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure --
GO:0007411 axon guidance TAS --
GO:0030509 BMP signaling pathway IBA --
GO:0030510 regulation of BMP signaling pathway --
genes like me logo Genes that share ontologies with RGMA: view

Transcripts for RGMA Gene

Unigene Clusters for RGMA Gene

RGM domain family, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGMA Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8
SP1: - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7: - - -
SP8: - -

Relevant External Links for RGMA Gene

GeneLoc Exon Structure for
RGMA
ECgene alternative splicing isoforms for
RGMA

Expression for RGMA Gene

mRNA expression in normal human tissues for RGMA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGMA Gene

This gene is overexpressed in Muscle - Skeletal (5.7) and Esophagus - Muscularis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGMA Gene

SOURCE GeneReport for Unigene cluster for RGMA Gene Hs.271277

genes like me logo Genes that share expressions with RGMA: view

No data available for mRNA Expression by UniProt/SwissProt for RGMA Gene

Orthologs for RGMA Gene

This gene was present in the common ancestor of animals.

Orthologs for RGMA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGMA 35
  • 99.63 (n)
  • 99.78 (a)
RGMA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGMA 35
  • 91.73 (n)
  • 93.08 (a)
RGMA 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGMA 35
  • 91.93 (n)
  • 94.23 (a)
RGMA 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgma 35
  • 89.1 (n)
  • 93.97 (a)
Rgma 16
Rgma 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGMA 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGMA 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgma 35
  • 89.53 (n)
  • 94.42 (a)
chicken
(Gallus gallus)
Aves RGMA 35
  • 82.22 (n)
  • 84.94 (a)
RGMA 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGMA 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rgma-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rgma 35
  • 75.64 (n)
  • 78.85 (a)
zebrafish
(Danio rerio)
Actinopterygii rgma 35
  • 68.71 (n)
  • 70.02 (a)
rgma 36
  • 63 (a)
OneToOne
wufb36g11 35
worm
(Caenorhabditis elegans)
Secernentea drag-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for RGMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGMA Gene

ENSEMBL:
Gene Tree for RGMA (if available)
TreeFam:
Gene Tree for RGMA (if available)

Paralogs for RGMA Gene

Paralogs for RGMA Gene

Selected SIMAP similar genes for RGMA Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with RGMA: view

Variants for RGMA Gene

Sequence variations from dbSNP and Humsavar for RGMA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13167 -- 93,043,872(+) GGGCA(C/T)AGCAG utr-variant-3-prime
rs749611 -- 93,070,001(+) CCTTC(C/G)TAGGT intron-variant
rs997941 -- 93,083,603(+) GAATT(A/G)TAAAT intron-variant
rs1012200 -- 93,082,239(+) GTATG(A/T)ACAGG intron-variant
rs1320818 -- 93,076,065(+) GCACT(C/G)CGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGMA Gene

Variant ID Type Subtype PubMed ID
dgv157n21 CNV Loss 19592680
dgv2437n71 CNV Loss 21882294
nsv523617 CNV Loss 19592680
nsv833096 CNV Loss 17160897

Relevant External Links for RGMA Gene

HapMap Linkage Disequilibrium report
RGMA
Human Gene Mutation Database (HGMD)
RGMA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGMA Gene

Disorders for RGMA Gene

Relevant External Links for RGMA

Genetic Association Database (GAD)
RGMA
Human Genome Epidemiology (HuGE) Navigator
RGMA
genes like me logo Genes that share disorders with RGMA: view

No data available for UniProtKB/Swiss-Prot for RGMA Gene

Publications for RGMA Gene

  1. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PMID: 17472960) Xia Y. … Lin H.Y. (J. Biol. Chem. 2007) 3 23
  2. Emerging roles for neogenin and its ligands in CNS development. (PMID: 18485097) De Vries M. … Cooper H.M. (J. Neurochem. 2008) 3 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. (PMID: 15975920) Babitt J.L. … Lin H.Y. (J. Biol. Chem. 2005) 2 3

Products for RGMA Gene

Sources for RGMA Gene

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