Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGMA Gene

protein-coding GIFtS: 59
GCID: GC15M093586

RGM Domain Family, Member A

7 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
RGM Domain Family, Member A¹ ²
RGM² ³
Repulsive Guidance Molecule A²
RGM Domain Family Member A³

External Ids:	HGNC: 30308¹	Entrez Gene: 56963²	Ensembl: ENSG00000182175⁷	OMIM: 607362⁵	UniProtKB: Q96B86³

Export aliases for RGMA gene to outside databases

Previous GC identifers: GC15M091173 GC15M091316 GC15M091387 GC15M069723

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGMA Gene:

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a

glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing

and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate

splicing results in multiple transcript variants. (provided by RefSeq, Oct 2009)

GeneCards Summary for RGMA Gene:

RGMA (RGM domain family, member A) is a protein-coding gene. Diseases associated with RGMA include gastric ulcer, and hodgkin's lymphoma, and among its related super-pathways are Axon guidance and DCC mediated attractive signaling. An important paralog of this gene is RGMB.

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86

Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing

and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron

branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of

RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the

neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS

inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)

coreceptor that may signal through SMAD1, SMAD5, and SMAD8

Gene Wiki entry for RGMA Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.2 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGMA gene promoter:
GR STAT1 AML1a p53 GR-beta STAT1beta Nkx2-5 STAT1alpha Ik-2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGMA promoter sequence

Search SABiosciences Chromatin IP Primers for RGMA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGMA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1

RGMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGMA gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M093586: view genomic region (about GC identifiers)

Start:	93,586,636 bp from pter	End:	93,632,443 bp from pter
Size:	45,808 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86 (See protein sequence)

Recommended Name: Repulsive guidance molecule A precursor

Size: 450 amino acids; 49347 Da

Subunit: Interacts with NEO1, BMP2 and BMP4 (By similarity)

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)

Secondary accessions: B2RTW1 Q0JV97 Q8NC80 Q9H0E6 Q9NPM3

Alternative splicing: 2 isoforms: Q96B86-1 Q96B86-2 (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGMA: NX_Q96B86

Explore proteomics data for RGMA at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96B86

RGMA Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (6 alternative transcripts):

NP_001159755.1 NP_001159758.1 NP_001159759.1 NP_001159760.1 NP_001159761.1 NP_064596.2

ENSEMBL proteins:

ENSP00000330005 ENSP00000440025 ENSP00000451505 ENSP00000452126 ENSP00000452170

ENSP00000456290 ENSP00000455634 ENSP00000451709 ENSP00000452350 ENSP00000442498

ENSP00000404442 ENSP00000442546

Reactome Protein details: Q96B86
Human Recombinant Protein Products for RGMA:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for RGMA (RGM-A)
	Enzo Life Sciences proteins for RGMA
	OriGene Purified Protein for RGMA OriGene Protein Over-expression Lysate for RGMA OriGene MassSpec for RGMA OriGene Custom Protein Services for RGMA
	GenScript Custom Purified and Recombinant Proteins Services for RGMA
	Novus Biologicals RGMA Protein Novus Biologicals RGMA Lysates
	Sino Biological Recombinant Protein for RGMA Sino Biological Cell Lysate for RGMA
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RGMA

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	--	--
GO:0031225	anchored to membrane	IEA	--

RGMA for ontologies About GeneDecksing

RGMA Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for RGMA (RGM-A)
	Browse OriGene Antibodies OriGene Custom Antibody Services for RGMA
	GenScript Superior Antibodies for RGMA
	Novus Biologicals RGMA Antibodies
	Abcam antibodies for RGMA
	Cloud-Clone Corp. Antibodies for RGMA
	Search ThermoFisher Antibodies for RGMA
	LSBio Antibodies in human, mouse, rat for RGMA

Assay Products for RGMA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RGMA
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RGMA
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RGMA Cloud-Clone Corp. CLIAs for RGMA

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR009496 RGM_C

IPR010536 RGM_N

Graphical View of Domain Structure for InterPro Entry Q96B86

ProtoNet protein and cluster: Q96B86

1 Blocks protein domain: IPB009496 Repulsive guidance molecule

UniProtKB/Swiss-Prot: RGMA_HUMAN, Q96B86

Similarity: Belongs to the repulsive guidance molecule (RGM) family

RGMA for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RGMA_HUMAN, Q96B86

Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing

and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron

branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of

RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the

neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS

inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP)

coreceptor that may signal through SMAD1, SMAD5, and SMAD8

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0015026	coreceptor activity	--	--

RGMA for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rgma):

craniofacial

embryogenesis

mortality/aging

nervous system

skeleton

RGMA for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Rgma^tm1Arbr for RGMA

inGenious Targeting Laboratory - Custom generated mouse model solutions for RGMA

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGMA

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGMA

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGMA

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGMA
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate RGMA (see all 65):
		hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: RGMA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RGMA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGMA

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RGMA
			Sirion Biotech Customized adenovirus for overexpression of RGMA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for RGMA (see all 27) OriGene ORF clones in mouse, rat for RGMA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): RGMA (NM_020211)
		Sino Biological Human cDNA Clone for RGMA
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMA
		Sirion Biotech Customized lentivirus for stable overexpression of RGMA Customized lentivirus expression plasmids for stable overexpression of RGMA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RGMA
		Search LifeMap BioReagents cell lines for RGMA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RGMA About

See pathways by source

SuperPath

Contained pathways About

Axon guidance

Axon guidance

0.69

Developmental Biology

0.69

Netrin-1 signaling

Netrin-1 signaling

0.33

Signaling by BMP

BMP receptor signaling

0.31

Spinal Cord Injury

Spinal Cord Injury

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for RGMA

	Spinal Cord Injury
	BMP receptor signaling

3 Reactome Pathways for RGMA

	Developmental Biology
	Netrin-1 signaling
	Axon guidance

RGMA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RGMA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for RGMA (Q96B86^{2, 3} ENSP00000330005⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1R16A	Q96I34²^,³	MINT-65185 I2D: score=5
SGSM2	O43147²^,³	MINT-64871 I2D: score=5
AHSG	ENSP00000393887⁴	STRING: ENSP00000393887
BAMBI	ENSP00000364683⁴	STRING: ENSP00000364683
BMP2	ENSP00000368104⁴	STRING: ENSP00000368104

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001843	neural tube closure	--	--
GO:0007411	axon guidance	TAS	--
GO:0030509	BMP signaling pathway	--	--
GO:0030510	regulation of BMP signaling pathway	--	--

RGMA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGMA

Search CenterWatch for drugs/clinical trials and news about RGMA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGMA gene (6 alternative transcripts):

NM_001166283.1 NM_001166286.1 NM_001166287.1 NM_001166288.1 NM_001166289.1 NM_020211.2

Unigene Cluster for RGMA:

RGM domain family, member A

Hs.271277 [show with all ESTs]

Unigene Representative Sequence: AK125047

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000329082(uc002bss.2) ENST00000542321(uc002bsq.2) ENST00000554387

ENST00000557301 ENST00000557420 ENST00000556658 ENST00000556087 ENST00000555584

ENST00000555598 ENST00000557608 ENST00000556950 ENST00000543599(uc021svu.1)

ENST00000425933(uc021svs.1 uc021svt.1 uc010urc.2) ENST00000538818(uc010boi.2 uc002bsr.2)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGMA
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate RGMA (see all 65):
		hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-3613-3p hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: RGMA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RGMA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGMA

Clone Products:		OriGene clones in human, mouse for RGMA (see all 27) OriGene ORF clones in mouse, rat for RGMA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): RGMA (NM_020211)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGMA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMA
		Sirion Biotech Customized lentivirus for stable overexpression of RGMA Customized lentivirus expression plasmids for stable overexpression of RGMA

Primer Products:		OriGene qPCR primer pairs and template standards for RGMA OriGene qSTAR qPCR primer pairs in human, mouse for RGMA
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RGMA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMA

Additional mRNA sequence:

AK074910.1 AK074966.1 AK074980.1 AK125047.1 AK125204.1 AK291365.1 AK299363.1 AK309814.1

AL136826.1 AL390083.1 BC015886.1 BC127826.1 BC140838.1 BC151132.1

14 DOTS entries:

DT.115395 DT.91678544 DT.91895498 DT.121072991 DT.121073001 DT.121072978 DT.121073005 DT.121072969

DT.121072976 DT.121072984 DT.121072997 DT.75103741 DT.95218133 DT.97841692

24/113 AceView cDNA sequences (see all 113):

AI611126 CD514254 BF941898 BF059155 AI673327 AW172788 CN479256 AI982513

AW410706 CK821199 BI962598 BM703696 BF529098 AI801457 BC015886 BM805742

BI822323 AL390083 BQ446865 BE294286 BI916507 AK074980 BM467742 BM717591

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RGMA (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8
SP1:											-		-		-						-
SP2:			-		-		-		-		-		-		-						-
SP3:					-		-		-		-		-		-				-		-
SP4:											-		-		-				-		-
SP5:													-		-				-		-

ECgene alternative splicing isoforms for RGMA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGMA expression in normal human tissues (normalized intensities) RGMA embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTCACCTGGC

About this image

RGMA expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/5 selected tissues (see all 5) fully expand


Neural Tube (Nervous System) fully expand to see all 4 entries
Metencephalon

Gut Tube (Gastrointestinal Tract)
Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

Adipose (Muscoskeletal System)
epididymal fat pads

Brain (Nervous System)
ganglion/cranial/vestibulocochlear VIII

Oral Cavity (Gastrointestinal Tract)
mouth

See RGMA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGMA

SOURCE GeneReport for Unigene cluster: Hs.271277

SABiosciences Expression via Pathway-Focused PCR Array including RGMA:

Stem Cell Signaling in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for RGMA OriGene qSTAR qPCR primer pairs in human, mouse for RGMA
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RGMA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RGMA gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rgma^{1 , 5}	RGM domain family, member A^{1, 5}	88.51(n)¹ 93.2(a)¹		7 (41.85 cM)⁵ 244058¹ NM_177740.5¹ NP_808408.2¹ 73375520⁵
chicken (Gallus gallus)	Aves	RGMA¹	RGM domain family, member A	82.76(n) 86.14(a)		395214 NM_204537.1 NP_989868.1
lizard (Anolis carolinensis)	Reptilia	RGMA⁶	RGM domain family, member A	72(a)	1 ↔ 1	GL343392.1(947511-1006031)
African clawed frog (Xenopus laevis)	Amphibia	rgma-prov²	repulsive guidance molecule A	80.27(n)		BC045008.1
zebrafish (Danio rerio)	Actinopterygii	wufb36g11²	wufb36g11	74.13(n)		321842 BC054682.1
worm (Caenorhabditis elegans)	Secernentea	drag-1⁶	Protein DRAG-1	22(a)	1 → many	I(1680450-1685063)

ENSEMBL Gene Tree for RGMA (if available)
TreeFam Gene Tree for RGMA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RGMA gene

RGMB² HFE2²

3 SIMAP similar genes for RGMA using alignment to 10 protein entries: RGMA_HUMAN (see all proteins):

YBX2 RGMB HFE2

RGMA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_062144⁴		--	--	see VAR_062144	2	D E	mis⁴		0	--	--	--	--
rs149211443^1,2	C	--	73356350(+)	`CCCCAC/TCCTCT`	1	--	us2k¹		0	--	--	--	--
rs201297072^1,2	C	--	73356357(+)	`CTCTA-/GGGAGT`	1	--	us2k¹		0	--	--	--	--
rs143397169^1,2	C	--	73356382(+)	`CTTTCC/GTTCCT`	1	--	us2k¹		0	--	--	--	--
rs4778099^1,2	C,F,A,H	--	73356903(+)	`GCCGTG/AAAGTG`	1	--	us2k¹		31		NS EA NA WA	3196
rs116407371^1,2	C,F	--	73356905(+)	`CGTGAA/GGTGTG`	1	--	us2k¹		1		WA	118
rs73460360^1,2	C,F	--	73357065(+)	`GAGTTT/CAAAAA`	1	--	us2k¹		2		WA	120
rs12442144^1,2	C,F,A,H	--	93586217(+)	`ACCACA/GTAGTC`	6	--	ds500¹		23		NA NS EA CSA	2346
rs138095056^1,2	C	--	93586217(+)	`ACCAC-/ATAGTCA`	6	--	ds500¹		0	--	--	--	--
rs75329370^1,2	C	--	93586218(+)	`CCACA-/TAGTCAC`	6	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RGMA (93586636 - 93632443 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for RGMA: About this table

Variant ID	Type	Subtype	PubMed ID
nsv523617	CNV	Loss	19592680
nsv833096	CNV	Loss	17160897
dgv2437n71	CNV	Loss	21882294
dgv157n21	CNV	Loss	19592680

Human Gene Mutation Database (HGMD): RGMA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGMA

DNA2.0 Custom Variant and Variant Library Synthesis for RGMA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 607362 OMIM disorders: --

7 diseases for RGMA: About MalaCards

gastric ulcer hodgkin's lymphoma multiple sclerosis colon cancer

colorectal cancer breast cancer neuronitis

RGMA for disorders About GeneDecksing

Genetic Association Database (GAD): RGMA
Human Genome Epidemiology (HuGE) Navigator: RGMA (2 documents)

Export disorders for RGMA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RGMA gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with RGMA)

Utopia: connect your pdf to the dynamic
world of online information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
RGMA and IL21R show association with experimental inf lammation and multiple sclerosis. (PubMed id 20072140)^{1, 4} Nohra R....Olsson T. (2010)
Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. (PubMed id 19458235)^{1, 2} Endo M. and Yamashita T. (2009)
Unc5B associates with LARG to mediate the action of repulsive guidance molecule. (PubMed id 19273616)^{1, 2} Hata K.... Yamashita T. (2009)
Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)^{1, 4} Verma R....Levinson D.F. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PubMed id 17472960)^{1, 9} Xia Y....Lin H.Y. (2007)
Emerging roles for neogenin and its ligands in CNS development. (PubMed id 18485097)^{1, 9} De Vries M. and Cooper H.M. (2008)
Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of pr ostate cancer cells. (PubMed id 22076499)¹ Li J....Jiang W.G. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56963	HGNC: 30308	AceView: RGMA	Ensembl:ENSG00000182175	euGenes: HUgn56963
ECgene: RGMA	H-InvDB: RGMA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RGMA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RGMA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RGMA gene:
Search GeneIP for patents involving RGMA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for RGMA (RGM-A)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Recombinant/Natural Proteins for RGMA (RGM-A)
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for RGMA
	OriGene qPCR primer pairs and template standards for RGMA		OriGene Protein Over-expression Lysate for RGMA
	OriGene MassSpec something-or-other for RGMA		OriGene clones in human, mouse for RGMA
	OriGene qSTAR qPCR primer pairs in human, mouse for RGMA		OriGene Purified Protein for RGMA
	OriGene ORF clones in mouse, rat for RGMA		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RGMA		OriGene Custom Protein Services for RGMA

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGMA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGMA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGMA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGMA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGMA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGMA

	GenScript Custom Purified and Recombinant Proteins Services for RGMA		GenScript cDNA clones with any tag delivered in your preferred vector for RGMA
	GenScript Custom Assay Services for RGMA		GenScript Superior Antibodies for RGMA
	GenScript Custom overexpressing Cell Line Services for RGMA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RGMA promoter
	Search Chromatin IP Primers for RGMA
	RT² qPCR Primer Assay in human, mouse, rat RGMA
	GNC Network for RGMA
	SABiosciences PCR Arrays including human, mouse, rat RGMA

Search Tocris compounds for RGMA

	Proteins and Antibodies for RGMA
	Cell Lysates for RGMA
	cDNA Clones for RGMA
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

	Proteins for RGMA
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RGMA antibodies
	RGMA proteins
	RGMA lysates

	Antibodies for RGMA
	See all of Abcam's Antibodies, Kits and Proteins for RGMA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for RGMA
	Antibodies for RGMA
	ELISAs for RGMA
	CLIAs for RGMA

Search LifeMap BioReagents cell lines for RGMA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGMA

	SwitchGear 3'UTR luciferase reporter plasmids for RGMA
	SwitchGear Promoter luciferase reporter plasmids for RGMA

Search ThermoFisher Antibodies for RGMA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGMA

	inGenious Targeting Laboratory - Custom generated mouse model solutions for RGMA
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGMA

Customized:

	lentivirus for stable overexpression of RGMA
	lentivirus expression plasmids for stable overexpression of RGMA
	adenovirus for overexpression of RGMA

LSBio Antibodies in human, mouse, rat for RGMA

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RGMA gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

RGMA Gene

RGM Domain Family, Member A

Aliases
for RGMA gene

Summaries
for RGMA gene

Genomic Views
for RGMA gene

Proteins
for RGMA gene

Protein Domains /
Families
for RGMA gene

Function
for RGMA gene

Pathways & Interactions
for RGMA gene

Drugs & Compounds
for RGMA gene

Transcripts
for RGMA gene

Expression
for RGMA gene

Orthologs
for RGMA gene

Paralogs
for RGMA gene

Genomic Variants
for RGMA gene

Disorders / Diseases
for RGMA gene

Publications
for RGMA gene

External Searches for RGMA gene

Genome Databases showing RGMA gene

Other Databases showing RGMA gene

Specialized Databases showing RGMA gene

Intellectual Property
for RGMA gene

Products
for RGMA gene

View Random Gene

Advanced Search

Export list of displayed genes

RGMA Gene

RGM Domain Family, Member A

Aliasesfor RGMA gene

Summariesfor RGMA gene

Genomic Viewsfor RGMA gene

Proteinsfor RGMA gene

Protein Domains /Familiesfor RGMA gene

Functionfor RGMA gene

Pathways & Interactionsfor RGMA gene

Drugs & Compoundsfor RGMA gene

Transcriptsfor RGMA gene

Expression for RGMA gene

Orthologsfor RGMA gene

Paralogsfor RGMA gene

Genomic Variantsfor RGMA gene

Disorders / Diseasesfor RGMA gene

Publicationsfor RGMA gene

External Searches for RGMA gene

Genome Databases showing RGMA gene

Other Databases showing RGMA gene

Specialized Databases showing RGMA gene

Intellectual Propertyfor RGMA gene

Productsfor RGMA gene

View Random Gene

Aliases
for RGMA gene

Summaries
for RGMA gene

Genomic Views
for RGMA gene

Proteins
for RGMA gene

Protein Domains /
Families
for RGMA gene

Function
for RGMA gene

Pathways & Interactions
for RGMA gene

Drugs & Compounds
for RGMA gene

Transcripts
for RGMA gene

Expression
for RGMA gene

Orthologs
for RGMA gene

Paralogs
for RGMA gene

Genomic Variants
for RGMA gene

Disorders / Diseases
for RGMA gene

Publications
for RGMA gene

Intellectual Property
for RGMA gene

Products
for RGMA gene