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Aliases for RGL4 Gene

Aliases for RGL4 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator-Like 4 2 3 4
  • Rgr 3 4 6
  • RalGDS Related Oncogene 2 3
  • RalGDS-Like 4 3 4
  • HRGR 3 4
  • Ral-GDS Related Protein Rgr 3
  • Ral-GDS-Related Protein 3

External Ids for RGL4 Gene

Previous GeneCards Identifiers for RGL4 Gene

  • GC22P022360
  • GC22P024030
  • GC22P007020

Summaries for RGL4 Gene

GeneCards Summary for RGL4 Gene

RGL4 (Ral Guanine Nucleotide Dissociation Stimulator-Like 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL4 Gene

Genomics for RGL4 Gene

Regulatory Elements for RGL4 Gene

Genomic Location for RGL4 Gene

23,688,136 bp from pter
23,699,176 bp from pter
11,041 bases
Plus strand

Genomic View for RGL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL4 Gene

Proteins for RGL4 Gene

  • Protein details for RGL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ral-GDS-related protein
    Protein Accession:
    Secondary Accessions:
    • Q495L8

    Protein attributes for RGL4 Gene

    473 amino acids
    Molecular mass:
    52346 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01109.1; Type=Frameshift; Positions=61; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL4 Gene


neXtProt entry for RGL4 Gene

Proteomics data for RGL4 Gene at MOPED

Post-translational modifications for RGL4 Gene

  • Ubiquitination at Lys417
  • Modification sites at PhosphoSitePlus

Other Protein References for RGL4 Gene

No data available for DME Specific Peptides for RGL4 Gene

Domains for RGL4 Gene

Protein Domains for RGL4 Gene

Suggested Antigen Peptide Sequences for RGL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8IZJ4
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RGL4: view

No data available for Gene Families for RGL4 Gene

Function for RGL4 Gene

Gene Ontology (GO) - Molecular Function for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RGL4: view
genes like me logo Genes that share phenotypes with RGL4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGL4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RGL4 Gene

Localization for RGL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGL4 Gene

Cytoplasmic vesicle.

Subcellular locations from

Jensen Localization Image for RGL4 Gene COMPARTMENTS Subcellular localization image for RGL4 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with RGL4: view

Pathways for RGL4 Gene

genes like me logo Genes that share pathways with RGL4: view

Pathways by source for RGL4 Gene

Gene Ontology (GO) - Biological Process for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGL4: view

Transcripts for RGL4 Gene

Unigene Clusters for RGL4 Gene

Ral guanine nucleotide dissociation stimulator-like 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGL4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RGL4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGL4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - -
SP7: -

Relevant External Links for RGL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGL4 Gene

mRNA expression in normal human tissues for RGL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL4 Gene

This gene is overexpressed in Whole Blood (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGL4 Gene

SOURCE GeneReport for Unigene cluster for RGL4 Gene Hs.658997

genes like me logo Genes that share expressions with RGL4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGL4 Gene

Orthologs for RGL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGL4 35
  • 96.48 (n)
  • 93.33 (a)
RGL4 36
  • 92 (a)
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
-- 36
  • 38 (a)
-- 36
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia RGL4 36
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 10 (a)
Species with no ortholog for RGL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RGL4 Gene

Gene Tree for RGL4 (if available)
Gene Tree for RGL4 (if available)

Paralogs for RGL4 Gene Pseudogenes for RGL4 Gene

genes like me logo Genes that share paralogs with RGL4: view

Variants for RGL4 Gene

Sequence variations from dbSNP and Humsavar for RGL4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
VAR_016244 -
VAR_016245 -
VAR_016246 -
VAR_016247 -
VAR_051905 -

Structural Variations from Database of Genomic Variants (DGV) for RGL4 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914593 CNV Loss 21882294
dgv4906n71 CNV Gain 21882294
nsv914595 CNV Gain 21882294
esv2751941 CNV Gain 17911159

Relevant External Links for RGL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL4 Gene

Disorders for RGL4 Gene

No disorders were found for RGL4 Gene.

No data available for UniProtKB/Swiss-Prot for RGL4 Gene

Publications for RGL4 Gene

  1. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. (PMID: 9178890) D'Adamo D.R. … Pellicer A. (Oncogene 1997) 2 3
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways. (PMID: 10851075) Hernandez-MuA+oz I. … Pellicer A. (Oncogene 2000) 2 3
  4. Human rgr: transforming activity and alteration in T-cell malignancies. (PMID: 12140761) Leonardi P. … Pellicer A. (Oncogene 2002) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RGL4 Gene

Sources for RGL4 Gene

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