RGL4 Gene
protein-coding GIFtS: 48
GCID: GC22P024030
|
|
ral guanine nucleotide dissociation stimulator-like 4
| |
Aliases
for RGL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ral Guanine Nucleotide Dissociation Stimulator-Like 41 2 3 | | RGR3 5 | | Rgr1 2 | | Ral-GDS Related Protein Rgr2 | | RalGDS-Like 42 3 | | Ral-GDS-Related Protein2 | | HRGR1 | | RalGDS Related Oncogene2 |
Export aliases for RGL4 gene to outside databasesPrevious GC identifers: GC22P022360 GC22P007020 |
Summaries
for RGL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RGL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RGL4 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 Roaz RORalpha2 E2F-1 E2F ARP-1 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RGL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23RGL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P024030: view genomic region
(about GC identifiers)
Start:
|
24,030,323 bp from pter |
End:
|
24,041,363 bp from pter |
Size:
|
11,041 bases |
Orientation:
|
plus strand |
|
Proteins
for RGL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RGDSR_HUMAN, Q8IZJ4 (See
protein sequence)Recommended Name: Ral-GDS-related protein Size: 473 amino acids; 52346 Da
Subcellular location: Cytoplasmic vesicle (By similarity)Alternative splicing: 1 isoform: Q8IZJ4-1 Explore the universe of human proteins at neXtProt for RGL4: NX_Q8IZJ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZJ4
RGL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_705843.1
ENSEMBL proteins: ENSP00000396252 ENSP00000383951 ENSP00000290691 ENSP00000402142 ENSP00000393115
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- | | GO:0016023 | cytoplasmic membrane-bounded vesicle |
IEA | -- |
RGL4 for ontologies About GeneDecksing
RGL4 Antibody Products:
Assay Products for RGL4: |
Protein
Domains /
Families
for RGL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RGL4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZJ4ProtoNet protein and cluster: Q8IZJ4 1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25
UniProtKB/Swiss-Prot: RGDSR_HUMAN, Q8IZJ4Similarity: Contains 1 Ras-GEF domain |
Function
for RGL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGL4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGL4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RGL4 (NM_153615) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGL4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity |
IEA | -- |
RGL4 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RGL4:
|
Pathways & Interactions
for RGL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | |
1  BioSystems Pathway for RGL4
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGL4
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for RGL4 (Q8IZJ43 ENSP000002906914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
RGL4 for ontologies About GeneDecksing
|
Drugs & Compounds
for RGL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RGL4
Search CenterWatch for drugs/clinical trials and news about RGL4 / RGDSR
|
Transcripts
for RGL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RGL4 gene: NM_153615.1 Unigene Cluster for RGL4: Ral guanine nucleotide dissociation stimulator-like 4 Hs.658997 [show with all ESTs]Unigene Representative Sequence: AK1313408 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441897(uc002zxn.3 uc002zxo.3 uc002zxp.1) ENST00000401461
ENST00000290691 ENST00000460003 ENST00000423392 ENST00000467354(uc002zxq.3)
ENST00000452208 ENST00000460167
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGL4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGL4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RGL4 (NM_153615) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGL4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL4 |
Additional cDNA sequence: AK131340.1 AY101396.1 BC047947.1 BC101108.3 BC101109.2 BC101110.3 13 DOTS entries: DT.120677075 DT.91729998 DT.100043564 DT.120676971 DT.120676847 DT.100721089 DT.91671686 DT.100755068 DT.95274852 DT.120678035 DT.100743011 DT.100755069 DT.75152806 24/45 AceView cDNA sequences (see all 45): BM710540 BM694752 BM708524 BU730825 AW949377 AL713378 BX641033 AI858943 BM708080 BU731262 BG912392 U14910 BQ640662 AL712389 BQ638073 BG819215 AI417427 BM686346 BG818112 BX282693 BC027987 BM723398 BF347715 AL711844
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RGL4 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for RGL4
|
Expression
for RGL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RGL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCCTCAC
About this image
See RGL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGL4
SOURCE GeneReport for Unigene cluster: Hs.658997
SABiosciences Custom PCR Arrays for RGL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RGL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL4 |
Orthologs
for RGL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RGL4 gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
rgl3a6CABZ01077370.16 |
-- |
15(a)12(a) |
possible orthologpossible ortholog |
6(9551727-9586086) 3(13788487-13810335) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rgl6 |
Ral guanine nucleotide exchange factor |
11(a) |
1 → many |
3L(13899997-13918435) |
worm
(Caenorhabditis elegans) |
Secernentea |
rgl-16 |
Ral GDS-Like family member (rgl-1) |
11(a) |
1 → many |
X(3210463-3220357) |
ENSEMBL Gene Tree for RGL4 (if available)
TreeFam Gene Tree for RGL4 (if available) |
Paralogs
for RGL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RGL4 gene
- RALGPS22 RAPGEF12 RASGRF12 RGL22 SOS22 RASGRF22 SOS12 RGL32
- RALGPS12 RALGDS2 RGL12
7 SIMAP similar genes for RGL4 using alignment to 8 protein entries: RGDSR_HUMAN (see all proteins):ETFA DKFZp686C2469 RGL1 FLJ00371 RALGDS FLJ00185
RGL2
RGL4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RGL4
PGOHUM00000239659 PGOHUM00000246574
|
Genomic Variants
for RGL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RGL4
1 CNV: 8902 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGL4 |
|
Disorders
/ Diseases
for RGL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RGL4 for disorders About MalaCards
RGL4 for disorders About GeneDecksing
OMIM gene information: 612214
OMIM disorders: --
Export disorders for RGL4 gene to outside databases
|
Publications
for RGL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RGL4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RGL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human rgr: transforming activity and alteration in T-cell malignancies. (PubMed id 12140761)1, 2 Leonardi P....Pellicer A. (2002)
- The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways. (PubMed id 10851075)1, 3 Hernandez-Munoz I....Pellicer A. (2000)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. (PubMed id 9178890)1, 3 D'Adamo D.R....Pellicer A. (1997)
- rgr oncogene: activation by elimination of translational controls and mislocalization. (PubMed id 12874025)1 Hernandez-Munoz I....Pellicer A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells. (PubMed id 9154803)1 Stang S....Stone J.C. (1997)
- Biochemical and biological analyses of Rgr RalGEF oncogene. (PubMed id 16757319)9 Martello L.A. and Pellicer A. (2006)
|
External Searches for RGL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RGL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RGL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RGL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RGL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RGL4 gene:
Search GeneIP for patents involving RGL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RGL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RGL4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGL4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGL4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RGL4 | | OriGene 3'-UTR Clone for RGL4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGL4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGL4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGL4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGL4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGL4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL4 |
| |
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| |  |  |  |  | | | | |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL4 |
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