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Aliases for RGL4 Gene

Aliases for RGL4 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 4 2 3
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 4 3 4 5
  • RalGDS Related Oncogene 2 3
  • RalGDS-Like 4 3 4
  • HRGR 3 4
  • Rgr 3 4
  • Ral-GDS Related Protein Rgr 3

External Ids for RGL4 Gene

Previous GeneCards Identifiers for RGL4 Gene

  • GC22P022360
  • GC22P024030
  • GC22P007020

Summaries for RGL4 Gene

GeneCards Summary for RGL4 Gene

RGL4 (Ral Guanine Nucleotide Dissociation Stimulator Like 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL4 Gene

Genomics for RGL4 Gene

Regulatory Elements for RGL4 Gene

Enhancers for RGL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGL4 Gene

23,688,136 bp from pter
23,699,705 bp from pter
11,570 bases
Plus strand

Genomic View for RGL4 Gene

Genes around RGL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL4 Gene

Proteins for RGL4 Gene

  • Protein details for RGL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ral-GDS-related protein
    Protein Accession:
    Secondary Accessions:
    • Q495L8

    Protein attributes for RGL4 Gene

    473 amino acids
    Molecular mass:
    52346 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01109.1; Type=Frameshift; Positions=61; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL4 Gene


neXtProt entry for RGL4 Gene

Proteomics data for RGL4 Gene at MOPED

Post-translational modifications for RGL4 Gene

  • Ubiquitination at Lys 417
  • Modification sites at PhosphoSitePlus

Other Protein References for RGL4 Gene

No data available for DME Specific Peptides for RGL4 Gene

Domains & Families for RGL4 Gene

Protein Domains for RGL4 Gene

Suggested Antigen Peptide Sequences for RGL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RGL4: view

No data available for Gene Families for RGL4 Gene

Function for RGL4 Gene

genes like me logo Genes that share phenotypes with RGL4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGL4 Gene

Localization for RGL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGL4 Gene

Cytoplasmic vesicle.

Subcellular locations from

Jensen Localization Image for RGL4 Gene COMPARTMENTS Subcellular localization image for RGL4 gene
Compartment Confidence
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for RGL4 Gene

Pathways & Interactions for RGL4 Gene

SuperPathways for RGL4 Gene

genes like me logo Genes that share pathways with RGL4: view

Pathways by source for RGL4 Gene

1 GeneTex pathway for RGL4 Gene
1 BioSystems pathway for RGL4 Gene

Gene Ontology (GO) - Biological Process for RGL4 Gene


No data available for SIGNOR curated interactions for RGL4 Gene

Drugs & Compounds for RGL4 Gene

No Compound Related Data Available

Transcripts for RGL4 Gene

Unigene Clusters for RGL4 Gene

Ral guanine nucleotide dissociation stimulator-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGL4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - -
SP7: -

Relevant External Links for RGL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGL4 Gene

mRNA expression in normal human tissues for RGL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL4 Gene

This gene is overexpressed in Whole Blood (x11.6).

Protein differential expression in normal tissues from HIPED for RGL4 Gene

This gene is overexpressed in Tlymphocyte (45.5), Fetal gut (14.8), and NK cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGL4 Gene

SOURCE GeneReport for Unigene cluster for RGL4 Gene Hs.658997

genes like me logo Genes that share expression patterns with RGL4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RGL4 Gene

Orthologs for RGL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGL4 35
  • 96.48 (n)
  • 93.33 (a)
RGL4 36
  • 92 (a)
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
-- 36
  • 38 (a)
-- 36
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia RGL4 36
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 10 (a)
Species with no ortholog for RGL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RGL4 Gene

Gene Tree for RGL4 (if available)
Gene Tree for RGL4 (if available)

Paralogs for RGL4 Gene Pseudogenes for RGL4 Gene

genes like me logo Genes that share paralogs with RGL4: view

Variants for RGL4 Gene

Sequence variations from dbSNP and Humsavar for RGL4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_016244 -
VAR_016245 -
VAR_016246 -
VAR_016247 -
VAR_051905 -

Structural Variations from Database of Genomic Variants (DGV) for RGL4 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914593 CNV Loss 21882294
dgv4906n71 CNV Gain 21882294
nsv914595 CNV Gain 21882294
esv2751941 CNV Gain 17911159

Variation tolerance for RGL4 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGL4 Gene

Disorders for RGL4 Gene

Relevant External Links for RGL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGL4 Gene

Publications for RGL4 Gene

  1. Human rgr: transforming activity and alteration in T-cell malignancies. (PMID: 12140761) Leonardi P. … Pellicer A. (Oncogene 2002) 3 4 67
  2. The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways. (PMID: 10851075) Hernandez-MuA+oz I. … Pellicer A. (Oncogene 2000) 2 3
  3. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. (PMID: 9178890) D'Adamo D.R. … Pellicer A. (Oncogene 1997) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Biochemical and biological analyses of Rgr RalGEF oncogene. (PMID: 16757319) Martello L.A. … Pellicer A. (Meth. Enzymol. 2006) 23

Products for RGL4 Gene

Sources for RGL4 Gene