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Aliases for RGL3 Gene

Aliases for RGL3 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 3 2 3 5
  • RalGDS-Like 3 4

External Ids for RGL3 Gene

Previous GeneCards Identifiers for RGL3 Gene

  • GC19U990227
  • GC19M011727
  • GC19M011349
  • GC19M011365
  • GC19M011356
  • GC19M011495
  • GC19M011080

Summaries for RGL3 Gene

GeneCards Summary for RGL3 Gene

RGL3 (Ral Guanine Nucleotide Dissociation Stimulator Like 3) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling_RalB regulation pathway. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RGL3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

Additional gene information for RGL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL3 Gene

Genomics for RGL3 Gene

Regulatory Elements for RGL3 Gene

Enhancers for RGL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H011380 1.4 ENCODE dbSUPER 14.1 +37.0 36977 5 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ILF3 ZNF136 KRI1 TIMM29 ZNF627 ZNF433 ZNF844 ZNF442 ZNF44 ZNF563
GH19H011386 0.9 Ensembl ENCODE 20.8 +32.0 31983 1 SOX13 GATAD2A PKNOX1 TFAP4 FOXA2 SAP130 NFIL3 CEBPA KDM1A CUX1 RGL3 PLPPR2 KANK2 EPOR GC19P011409
GH19H011360 1 Ensembl ENCODE 17.4 +57.6 57620 2 KLF1 MAX ZIC2 HIC1 GLIS2 MTA3 POLR2A SCRT2 ZSCAN29 L3MBTL2 RGL3 PLPPR2 EPOR TSPAN16 SWSAP1
GH19H011404 0.9 Ensembl ENCODE 15.3 +13.6 13590 2 BCOR CTCF ZNF362 ZNF10 ZNF384 DPF2 NR2F2 IKZF1 ZSCAN5C ZBTB33 RGL3 PRKCSH GC19P011409 EPOR
GH19H011420 1.2 Ensembl ENCODE 11.4 -2.4 -2351 2 PKNOX1 KLF17 RFX5 ETS1 GLIS2 ZNF366 ZNF143 RUNX3 IKZF2 SP3 RGL3 PRKCSH
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGL3 on UCSC Golden Path with GeneCards custom track

Promoters for RGL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107178 442 1001 SREBF2 ARID4B PPARG THRB E2F1 ZFHX2 ZGPAT POLR2A MBD1 ETV4

Genomic Location for RGL3 Gene

Chromosome:
19
Start:
11,384,341 bp from pter
End:
11,419,342 bp from pter
Size:
35,002 bases
Orientation:
Minus strand

Genomic View for RGL3 Gene

Genes around RGL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL3 Gene

Proteins for RGL3 Gene

  • Protein details for RGL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIN7-RGL3_HUMAN
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 3
    Protein Accession:
    Q3MIN7
    Secondary Accessions:
    • B5ME84
    • B7ZL22
    • Q0P6G0

    Protein attributes for RGL3 Gene

    Size:
    710 amino acids
    Molecular mass:
    78079 Da
    Quaternary structure:
    • Interacts with GTP-bound forms of RIT1, HRAS and MRAS.
    SequenceCaution:
    • Sequence=AAH14426.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGL3 Gene

Post-translational modifications for RGL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGL3 Gene

Domains & Families for RGL3 Gene

Gene Families for RGL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q3MIN7

UniProtKB/Swiss-Prot:

RGL3_HUMAN :
  • The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.
Domain:
  • The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.
genes like me logo Genes that share domains with RGL3: view

Function for RGL3 Gene

Molecular function for RGL3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

Phenotypes From GWAS Catalog for RGL3 Gene

Gene Ontology (GO) - Molecular Function for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008321 Ral guanyl-nucleotide exchange factor activity IEA --
GO:0017016 Ras GTPase binding IEA --
GO:0031267 small GTPase binding IEA --
genes like me logo Genes that share ontologies with RGL3: view
genes like me logo Genes that share phenotypes with RGL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RGL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGL3 Gene

Localization for RGL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGL3 gene
Compartment Confidence
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGL3 Gene

Pathways & Interactions for RGL3 Gene

genes like me logo Genes that share pathways with RGL3: view

Pathways by source for RGL3 Gene

1 GeneGo (Thomson Reuters) pathway for RGL3 Gene

Gene Ontology (GO) - Biological Process for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGL3: view

No data available for SIGNOR curated interactions for RGL3 Gene

Drugs & Compounds for RGL3 Gene

(3) Drugs for RGL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGL3: view

Transcripts for RGL3 Gene

Unigene Clusters for RGL3 Gene

Ral guanine nucleotide dissociation stimulator-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RGL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RGL3 Gene

No ASD Table

Relevant External Links for RGL3 Gene

GeneLoc Exon Structure for
RGL3
ECgene alternative splicing isoforms for
RGL3

Expression for RGL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL3 Gene

This gene is overexpressed in Thyroid (x8.3) and Kidney - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for RGL3 Gene

This gene is overexpressed in Urine (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGL3 Gene



Protein tissue co-expression partners for RGL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGL3 Gene:

RGL3

SOURCE GeneReport for Unigene cluster for RGL3 Gene:

Hs.375142

Evidence on tissue expression from TISSUES for RGL3 Gene

  • Kidney(4.3)
  • Lung(4.2)
  • Heart(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RGL3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGL3 Gene

Orthologs for RGL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGL3 33 34
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia RGL3 33 34
  • 84.17 (n)
cow
(Bos Taurus)
Mammalia RGL3 33 34
  • 83.22 (n)
mouse
(Mus musculus)
Mammalia Rgl3 33 16 34
  • 80.31 (n)
rat
(Rattus norvegicus)
Mammalia Rgl3 33
  • 79.56 (n)
oppossum
(Monodelphis domestica)
Mammalia RGL3 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGL3 34
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGL3 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rgl3a 34
  • 34 (a)
OneToMany
RGL3 (1 of 2) 34
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rgl 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgl-1 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for RGL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGL3 Gene

ENSEMBL:
Gene Tree for RGL3 (if available)
TreeFam:
Gene Tree for RGL3 (if available)

Paralogs for RGL3 Gene

Paralogs for RGL3 Gene

genes like me logo Genes that share paralogs with RGL3: view

Variants for RGL3 Gene

Sequence variations from dbSNP and Humsavar for RGL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs544310246 Benign 11,420,918(+) CACTA(A/C)CTCGT upstream-variant-2KB, reference, missense
rs1000279978 -- 11,408,890(+) AGGAA(A/G)AAGGG intron-variant
rs1000471249 -- 11,408,584(+) CATCT(A/C)AAAAA intron-variant
rs1000538774 -- 11,395,367(+) TCAGC(A/G)TGAAT intron-variant
rs1000614110 -- 11,407,725(+) TCTGT(C/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGL3 Gene

Variant ID Type Subtype PubMed ID
esv1464086 CNV deletion 17803354
esv2673946 CNV deletion 23128226
esv3556030 CNV deletion 23714750
esv3643671 CNV loss 21293372
esv3643672 CNV loss 21293372
nsv519802 CNV loss 19592680
nsv833752 CNV loss 17160897
nsv953975 CNV deletion 24416366

Variation tolerance for RGL3 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.14; 97.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL3 Gene

Disorders for RGL3 Gene

Relevant External Links for RGL3

Genetic Association Database (GAD)
RGL3
Human Genome Epidemiology (HuGE) Navigator
RGL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGL3

No disorders were found for RGL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGL3 Gene

Publications for RGL3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 60
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 60

Products for RGL3 Gene

Sources for RGL3 Gene

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