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Aliases for RGL3 Gene

Aliases for RGL3 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator-Like 3 2 3
  • RalGDS-Like 3 4
  • ANXA5 6
  • ENX2 6
  • RP 6

External Ids for RGL3 Gene

Previous GeneCards Identifiers for RGL3 Gene

  • GC19U990227
  • GC19M011727
  • GC19M011349
  • GC19M011365
  • GC19M011356
  • GC19M011495
  • GC19M011080

Summaries for RGL3 Gene

GeneCards Summary for RGL3 Gene

RGL3 (Ral Guanine Nucleotide Dissociation Stimulator-Like 3) is a Protein Coding gene. Among its related pathways are Ca, cAMP and Lipid Signaling and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include Ras GTPase binding and Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RGL3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL3 Gene

Genomics for RGL3 Gene

Regulatory Elements for RGL3 Gene

Genomic Location for RGL3 Gene

Start:
11,384,341 bp from pter
End:
11,419,342 bp from pter
Size:
35,002 bases
Orientation:
Minus strand

Genomic View for RGL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL3 Gene

Proteins for RGL3 Gene

  • Protein details for RGL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIN7-RGL3_HUMAN
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 3
    Protein Accession:
    Q3MIN7
    Secondary Accessions:
    • B5ME84
    • B7ZL22
    • Q0P6G0

    Protein attributes for RGL3 Gene

    Size:
    710 amino acids
    Molecular mass:
    78079 Da
    Quaternary structure:
    • Interacts with GTP-bound forms of RIT1, HRAS and MRAS.
    SequenceCaution:
    • Sequence=AAH14426.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGL3 Gene

Proteomics data for RGL3 Gene at MOPED

Post-translational modifications for RGL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGL3 Gene

Domains for RGL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q3MIN7

UniProtKB/Swiss-Prot:

RGL3_HUMAN :
  • Q3MIN7
Domain:
  • The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RGL3: view

No data available for Gene Families for RGL3 Gene

Function for RGL3 Gene

Molecular function for RGL3 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

Gene Ontology (GO) - Molecular Function for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005515 protein binding --
GO:0008321 Ral guanyl-nucleotide exchange factor activity IEA --
GO:0017016 Ras GTPase binding IEA --
genes like me logo Genes that share ontologies with RGL3: view

miRNA for RGL3 Gene

miRTarBase miRNAs that target RGL3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGL3 Gene

Localization for RGL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGL3 Gene COMPARTMENTS Subcellular localization image for RGL3 gene
Compartment Confidence
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGL3 Gene

Pathways for RGL3 Gene

genes like me logo Genes that share pathways with RGL3: view

Pathways by source for RGL3 Gene

1 Cell Signaling Technology pathway for RGL3 Gene
1 BioSystems pathway for RGL3 Gene

Interacting Proteins for RGL3 Gene

Gene Ontology (GO) - Biological Process for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RGL3: view

Compounds for RGL3 Gene

(3) HMDB Compounds for RGL3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RGL3: view

Transcripts for RGL3 Gene

Unigene Clusters for RGL3 Gene

Ral guanine nucleotide dissociation stimulator-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGL3 Gene

No ASD Table

Relevant External Links for RGL3 Gene

GeneLoc Exon Structure for
RGL3
ECgene alternative splicing isoforms for
RGL3

Expression for RGL3 Gene

mRNA expression in normal human tissues for RGL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL3 Gene

This gene is overexpressed in Thyroid (8.3) and Kidney - Cortex (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGL3 Gene

SOURCE GeneReport for Unigene cluster for RGL3 Gene Hs.375142

genes like me logo Genes that share expressions with RGL3: view

No data available for mRNA Expression by UniProt/SwissProt for RGL3 Gene

Orthologs for RGL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGL3 35
  • 99.01 (n)
  • 98.31 (a)
RGL3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGL3 35
  • 83.22 (n)
  • 80.54 (a)
RGL3 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGL3 35
  • 84.17 (n)
  • 82.07 (a)
RGL3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgl3 35
  • 80.31 (n)
  • 79.32 (a)
Rgl3 16
Rgl3 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGL3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGL3 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgl3 35
  • 79.56 (n)
  • 78.93 (a)
lizard
(Anolis carolinensis)
Reptilia RGL3 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RGL3 (1 of 2) 36
  • 31 (a)
OneToMany
rgl3a 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rgl 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgl-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for RGL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGL3 Gene

ENSEMBL:
Gene Tree for RGL3 (if available)
TreeFam:
Gene Tree for RGL3 (if available)

Paralogs for RGL3 Gene

Selected SIMAP similar genes for RGL3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RGL3: view

Variants for RGL3 Gene

Sequence variations from dbSNP and Humsavar for RGL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs160523 -- 11,417,158(-) aaaaa(A/C/G)aaaaa intron-variant
rs160838 - 11,416,083(-) CCCTG(C/T)CCATT reference, missense
rs167479 - 11,416,089(-) AGACC(A/C)CCCTG reference, missense
rs222603 -- 11,402,833(-) atcgc(A/G)cctgg intron-variant
rs316501 -- 11,417,672(-) caaga(C/T)ggtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGL3 Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV Loss 17160897
nsv519802 CNV Loss 19592680
nsv911062 CNV Loss 21882294
esv1464086 CNV Deletion 17803354
esv2673946 CNV Deletion 23128226

Relevant External Links for RGL3 Gene

HapMap Linkage Disequilibrium report
RGL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL3 Gene

Disorders for RGL3 Gene

(1) OMIM Diseases for RGL3 Gene (131230)

Relevant External Links for RGL3

Genetic Association Database (GAD)
RGL3
Human Genome Epidemiology (HuGE) Navigator
RGL3
genes like me logo Genes that share disorders with RGL3: view

No data available for UniProtKB/Swiss-Prot for RGL3 Gene

Publications for RGL3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  3. A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. (PMID: 10869344) Shao H. … Andres D.A. (J. Biol. Chem. 2000) 2
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for RGL3 Gene

Sources for RGL3 Gene

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