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RGL2 Gene

protein-coding   GIFtS: 61
GCID: GC06M033259

Ral Guanine Nucleotide Dissociation Stimulator-Like 2

(Previous names: RAB2, member RAS oncogene family-like)
(Previous symbol: RAB2L)
  See RGL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ral Guanine Nucleotide Dissociation Stimulator-Like 21 2     RAB2, Member RAS Oncogene Family-Like1
RAB2L1 2 3 5     HKE1.52
RalGDS-Like 22 3     KE1.52
RalGDS-Like Factor2 3     GDS-Related Protein2
Ras-Associated Protein RAB2L2 3     

External Ids:    HGNC: 97691   Entrez Gene: 58632   Ensembl: ENSG000002374417   OMIM: 6023065   UniProtKB: O152113   
ORGUL members:         

Export aliases for RGL2 gene to outside databases

Previous GC identifers: GC06M033307 GC06M033367 GC06M033001


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RGL2 Gene:
RGL2 (ral guanine nucleotide dissociation stimulator-like 2) is a protein-coding gene. Diseases associated with RGL2 include normophosphatemic familial tumoral calcinosis, and familial tumoral calcinosis. GO annotations related to this gene include Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: RGL2_HUMAN, O15211
Function: Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the
GTP-bound form of Rap 1A and H-Ras in vitro (By similarity)

Gene Wiki entry for RGL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  NT_167248.2  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGL2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sp1   Pax-5   CUTL1   E2F-2   E2F   E2F-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGL2 promoter sequence
   Search Chromatin IP Primers for RGL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RGL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGL2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033259:  view genomic region     (about GC identifiers)

Start:
33,259,431 bp from pter      End:
33,267,176 bp from pter
Size:
7,746 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_113891.2 4,703,245-4,710,990      Chr6-,NT_167248 4,491,674-4,499,416      Chr6-,NT_167245 4,540,757-4,548,502     
Chr6-,NT_167247 4,733,175-4,740,920     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGL2_HUMAN, O15211 (See protein sequence)
Recommended Name: Ral guanine nucleotide dissociation stimulator-like 2  
Size: 777 amino acids; 83549 Da
Subunit: Interacts with SAMD9
Secondary accessions: Q5STK0 Q9Y3F3

Explore the universe of human proteins at neXtProt for RGL2: NX_O15211

Explore proteomics data for RGL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230667.1  NP_004752.1  

    ENSEMBL proteins: 
     ENSP00000420211   ENSP00000392918   ENSP00000403070  

    RGL2 Human Recombinant Protein Products:

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    Novus Biologicals RGL2 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RGL2

     
    Search eBioscience for Proteins for RGL2 

     
    antibodies-online proteins for RGL2 (3 products) 

     
    antibodies-online peptides for RGL2

    RGL2 Antibody Products:

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    antibodies-online antibodies for RGL2 (18 products) 

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    Cloud-Clone Corp. ELISAs for RGL2
    Cloud-Clone Corp. CLIAs for RGL2
    Search eBioscience for ELISAs for RGL2 
    antibodies-online kits for RGL2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc
     IPR019804 Ras_G-nucl-exch_fac_CS

    Graphical View of Domain Structure for InterPro Entry O15211

    ProtoNet protein and cluster: O15211

    2 Blocks protein domains:
    IPB000159 RA domain
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RGL2_HUMAN, O15211
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    Find genes that share domains with RGL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGL2_HUMAN, O15211
    Function: Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the
    GTP-bound form of Rap 1A and H-Ras in vitro (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005088Ras guanyl-nucleotide exchange factor activity NAS8976381
         
    Find genes that share ontologies with RGL2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGL2:
     Decreased nuclei size in G2M  Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RGL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RGL2:
    hsa-mir-335-5p (MIRT018288)

    Block miRNA regulation of human, mouse, rat RGL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGL2 (see all 11):
    hsa-miR-142-3p hsa-miR-328 hsa-miR-27a hsa-miR-324-3p hsa-miR-4255 hsa-miR-128 hsa-miR-3681* hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidRGL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RGL2
    Predesigned siRNA for gene silencing in human, mouse, rat RGL2

    Gene Editing
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    OriGene clones in human, mouse for RGL2 (see all 7)
    OriGene ORF clones in mouse, rat for RGL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGL2 (NM_004761)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RGL2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular IEA--

    Find genes that share ontologies with RGL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Antigen presentation by MHC class II
    G protein signaling N RAS regulation pathway0.46
    2Ras signaling pathway
    Ras signaling pathway0.36
    3G protein signaling K RAS regulation pathway
    G protein signaling K RAS regulation pathway
    4Cytoskeleton remodeling RalA regulation pathway
    Cytoskeleton remodeling RalA regulation pathway


    Find genes that share SuperPaths with RGL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for RGL2
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway


    1 Kegg Pathway  (Kegg details for RGL2):
        Ras signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGL2
    Interactions:

        Search GeneGlobe Interaction Network for RGL2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for RGL2 (O152113 ENSP000004202114) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=5 STRING: ENSP00000309845
    RAP1BP612243, ENSP000002505594I2D: score=4 STRING: ENSP00000250559
    CCDC90BQ9GZT63I2D: score=4 
    EEF1GP266413I2D: score=4 
    KAT5Q929933I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0007265Ras protein signal transduction NAS8976381
    GO:0032318regulation of Ras GTPase activity NAS8976381
    GO:0051056regulation of small GTPase mediated signal transduction ----

    Find genes that share ontologies with RGL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGL2

    3 HMDB Compounds for RGL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGL2 gene (2 alternative transcripts): 
    NM_001243738.1  NM_004761.4  

    Unigene Cluster for RGL2:

    Ral guanine nucleotide dissociation stimulator-like 2
    Hs.509622  [show with all ESTs]
    Unigene Representative Sequence: NM_004761
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491168 ENST00000483151 ENST00000437840(uc010jur.3) ENST00000497454(uc003odv.3 uc003odw.3 uc011drb.2)
    ENST00000471319 ENST00000476616 ENST00000478610 ENST00000494550 ENST00000485077
    ENST00000460988 ENST00000425946 ENST00000444031
    miRNA
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    Block miRNA regulation of human, mouse, rat RGL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGL2 (see all 11):
    hsa-miR-142-3p hsa-miR-328 hsa-miR-27a hsa-miR-324-3p hsa-miR-4255 hsa-miR-128 hsa-miR-3681* hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidRGL2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: RGL2 (NM_004761)
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    Primer
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    OriGene qPCR primer pairs and template standards for RGL2
    OriGene qSTAR qPCR primer pairs in human, mouse for RGL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGL2
      QuantiTect SYBR Green Assays in human, mouse, rat RGL2
      QuantiFast Probe-based Assays in human, mouse, rat RGL2

    Additional mRNA sequence: 

    AK095967.1 AL050259.1 BC000316.1 BC005037.1 BC032681.1 BX648015.1 D85757.1 U68142.1 

    23 DOTS entries:

    DT.99998208  DT.318123  DT.91809717  DT.121364717  DT.95340907  DT.99947740  DT.75124524  DT.95340908 
    DT.100789247  DT.121364627  DT.100728258  DT.100789254  DT.95340990  DT.100709336  DT.100789249  DT.100789250 
    DT.100789253  DT.97781926  DT.100029308  DT.100760268  DT.121364598  DT.121364720  DT.80100030 

    Selected AceView cDNA sequences (see all 315):

    BQ880134 AW190337 AA506506 BQ428588 CD243841 BF197904 AA699480 BX103940 
    BM469731 BM795280 BQ671771 AA907444 CA487740 BU162186 AA339803 BQ231500 
    BQ933219 AL047730 BM769947 BQ884252 AA526375 BQ955127 AA687824 CA417539 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGGCCAA
    RGL2 Expression
    About this image


    RGL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    RGL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509622
        Custom PCR Arrays for RGL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgl21 , 5 ral guanine nucleotide dissociation stimulator-like more1, 5 87.31(n)1
    89.83(a)1
      17 (17.98 cM)5
    197321  NM_009059.21  NP_033085.21 
     339295435 
    lizard
    (Anolis carolinensis)
    Reptilia RGL26
    ral guanine nucleotide dissociation stimulator-lik...
    52(a)
    1 ↔ 1
    GL343733.1(239737-277159)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgl21 ral guanine nucleotide dissociation stimulator-like more 51.84(n)
    45.71(a)
      100489210  XM_002938684.2  XP_002938730.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rgl21 ral guanine nucleotide dissociation stimulator-like more 52.86(n)
    46.23(a)
      65227  NM_001115093.2  NP_001108565.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgl6
    Ral guanine nucleotide exchange factor
    23(a)
    1 → many
    3L(13899997-13918435)
    worm
    (Caenorhabditis elegans)
    Secernentea rgl-16
    Protein RGL-1, isoform b (rgl-1) mRNA, complete cd...
    23(a)
    1 → many
    X(3210473-3220369) WBGene00017891


    ENSEMBL Gene Tree for RGL2 (if available)
    TreeFam Gene Tree for RGL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGL2 gene
    RALGPS22  RAPGEF12  RASGRF12  SOS22  RASGRF22  SOS12  RGL32  RALGDS2  
    RALGPS12  RGL12  RGL42  
    9 SIMAP similar genes for RGL2 using alignment to 8 protein entries:     RGL2_HUMAN (see all proteins):
    HKE1.5    FLJ00371    FLJ00185    RALGDS    FLJ00153    RGL4
    DKFZp686C2469    RGL3    RGL1

    Find genes that share paralogs with RGL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGL2 (see all 224)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894287171,2
    --33259491(+) CCCCCA/CGAGTG 2 -- ut310--------
    rs18018231,2
    C,F,A,H--33259582(-) ACATGC/TAAGGG 2 -- ut3113Minor allele frequency- T:0.03NA NS EA WA 1444
    rs1825199221,2
    --33259601(+) GGCCAA/CGAATC 2 -- ut310--------
    rs1858623251,2
    --33259619(+) GATGCA/GTTTTT 2 -- ut310--------
    rs77540651,2
    C,H--33259626(+) TTTTCC/GAGCAC 2 -- ut314Minor allele frequency- G:0.00NS EA 420
    rs1909269401,2
    --33259659(+) AAGGTG/TGGAAG 2 -- ut310--------
    rs2013152421,2
    C--33259866(+) GCCAAC/TGGGGC 2 -- ut311Minor allele frequency- T:0.00EU 979
    rs2006907431,2
    C--33259872(+) GGGGCG/TTCCTC 2 -- ut310--------
    rs1481511951,2
    C,F--33259903(+) ATCTTC/TCTCCC 4 R syn12Minor allele frequency- T:0.00NA EU 5793
    rs1159950161,2
    C,F--33259909(+) CTCCCT/CGTGGC 4 /T syn12Minor allele frequency- C:0.00WA NA 4766

    HapMap Linkage Disequilibrium report for RGL2 (33259431 - 33267176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    nsv830635CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602306    OMIM disorders: --

    2 diseases for RGL2:    
    About MalaCards
    normophosphatemic familial tumoral calcinosis    familial tumoral calcinosis


    Find genes that share disorders with RGL2           About GenesLikeMe

    Genetic Association Database (GAD): RGL2
    Human Genome Epidemiology (HuGE) Navigator: RGL2 (2 documents)

    Export disorders for RGL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGL2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with RGL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS. (PubMed id 8976381)1, 2, 3 Isomura M.... Nakamura Y. (Cytogenet. Cell Genet. 1996)
    2. Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis. (PubMed id 21160498)1, 2 Hershkovitz D....Sprecher E. (J. Invest. Dermatol. 2011)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)1, 2 Herberg J.A.... Trowsdale J. (J. Mol. Biol. 1998)
    7. G-protein binding features and regulation of the RalGDS family member, RGL2. (PubMed id 18540861)1, 9 Ferro E....Trabalzini L. (Biochem. J. 2008)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5863 HGNC: 9769 AceView: RGL2 Ensembl:ENSG00000237441 euGenes: HUgn5863
    ECgene: RGL2 Kegg: 5863 H-InvDB: RGL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGL2 gene:
    Search GeneIP for patents involving RGL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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