Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGL2 Gene

protein-coding   GIFtS: 58
GCID: GC06M033259

Ral Guanine Nucleotide Dissociation Stimulator-Like 2

(Previous names: RAB2, member RAS oncogene family-like)
(Previous symbol: RAB2L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ral Guanine Nucleotide Dissociation Stimulator-Like 21 2     RAB2, Member RAS Oncogene Family-Like1
RAB2L1 2 3 5     HKE1.52
RalGDS-Like 22 3     KE1.52
RalGDS-Like Factor2 3     GDS-Related Protein2
Ras-Associated Protein RAB2L2 3     

External Ids:    HGNC: 97691   Entrez Gene: 58632   Ensembl: ENSG000002374417   OMIM: 6023065   UniProtKB: O152113   
ORGUL members:         
NONCODE14:n408223      

Export aliases for RGL2 gene to outside databases

Previous GC identifers: GC06M033307 GC06M033367 GC06M033001


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RGL2 Gene: 
RGL2 (ral guanine nucleotide dissociation stimulator-like 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RGL2 include normophosphatemic familial tumoral calcinosis, and familial tumoral calcinosis, and among its related super-pathways are G-protein signaling K-RAS regulation pathway and G-protein signaling N-RAS regulation pathway. GO annotations related to this gene include Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: RGL2_HUMAN, O15211
Function: Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the
GTP-bound form of Rap 1A and H-Ras in vitro (By similarity)

Gene Wiki entry for RGL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167247.1  NT_167248.1  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGL2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sp1   Pax-5   CUTL1   E2F-2   E2F   E2F-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RGL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGL2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033259:  view genomic region     (about GC identifiers)

Start:
33,259,431 bp from pter      End:
33,267,176 bp from pter
Size:
7,746 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_167248 4,491,674-4,499,416      Chr6-,NT_167247 4,733,175-4,740,920      Chr6-,NT_113891.2 4,703,245-4,710,990     
Chr6-,NT_167245 4,540,757-4,548,502     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGL2_HUMAN, O15211 (See protein sequence)
Recommended Name: Ral guanine nucleotide dissociation stimulator-like 2  
Size: 777 amino acids; 83549 Da
Subunit: Interacts with SAMD9
Secondary accessions: Q5STK0 Q9Y3F3

Explore the universe of human proteins at neXtProt for RGL2: NX_O15211

Explore proteomics data for RGL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15211

  • RGL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230667.1  NP_004752.1  

    ENSEMBL proteins: 
     ENSP00000420211   ENSP00000392918   ENSP00000403070  

    Human Recombinant Protein Products for RGL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RGL2
    OriGene Protein Over-expression Lysate for RGL2
    OriGene MassSpec for RGL2 
    OriGene Custom Protein Services for RGL2
    GenScript Custom Purified and Recombinant Proteins Services for RGL2
    Novus Biologicals RGL2 Protein
    Novus Biologicals RGL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RGL2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular IEA--

    RGL2 for ontologies           About GeneDecksing



    RGL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RGL2
    GenScript Custom Superior Antibodies Services for RGL2
    Novus Biologicals RGL2 Antibodies
    Abcam antibodies for RGL2
    Cloud-Clone Corp. Antibodies for RGL2 
    ThermoFisher Antibodies for RGL2
    LSBio Antibodies in human, mouse, rat for RGL2 

    Assay Products for RGL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RGL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RGL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RGL2 
    Cloud-Clone Corp. CLIAs for RGL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc
     IPR019804 Ras_G-nucl-exch_fac_CS

    Graphical View of Domain Structure for InterPro Entry O15211

    ProtoNet protein and cluster: O15211

    2 Blocks protein domains:
    IPB000159 RA domain
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RGL2_HUMAN, O15211
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    RGL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGL2_HUMAN, O15211
    Function: Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the
    GTP-bound form of Rap 1A and H-Ras in vitro (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005088Ras guanyl-nucleotide exchange factor activity NAS8976381
         
    RGL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGL2:
     Decreased nuclei size in G2M  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGL2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RGL2 (see all 11):
    hsa-miR-142-3p hsa-miR-328 hsa-miR-27a hsa-miR-324-3p hsa-miR-4255 hsa-miR-128 hsa-miR-3681* hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidRGL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RGL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RGL2
    Sirion Biotech Customized adenovirus for overexpression of RGL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RGL2 (see all 8)
    OriGene ORF clones in mouse, rat for RGL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGL2 (NM_004761)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL2
    Sirion Biotech Customized lentivirus for stable overexpression of RGL2 
                         Customized lentivirus expression plasmids for stable overexpression of RGL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RGL2
    Search LifeMap BioReagents cell lines for RGL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling K-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway0.96
    2G-protein signaling N-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway0.83
    3Cytoskeleton remodeling RalA regulation pathway
    Cytoskeleton remodeling RalA regulation pathway1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for RGL2
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway


    3 GeneGo (Thomson Reuters) Pathways for RGL2
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway



    RGL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGL2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/15 Interacting proteins for RGL2 (O152113 ENSP000004202114) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=5 STRING: ENSP00000309845
    RAP1BP612243, ENSP000002505594I2D: score=4 STRING: ENSP00000250559
    CCDC90BQ9GZT63I2D: score=4 
    EEF1GP266413I2D: score=4 
    KAT5Q929933I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0007265Ras protein signal transduction NAS8976381
    GO:0051056regulation of small GTPase mediated signal transduction IEA--

    RGL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGL2

    3 HMDB Compounds for RGL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RGL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGL2 gene (2 alternative transcripts): 
    NM_001243738.1  NM_004761.4  

    Unigene Cluster for RGL2:

    Ral guanine nucleotide dissociation stimulator-like 2
    Hs.509622  [show with all ESTs]
    Unigene Representative Sequence: NM_004761
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491168 ENST00000483151 ENST00000437840(uc010jur.3) ENST00000497454(uc003odv.3 uc003odw.3 uc011drb.2)
    ENST00000471319 ENST00000476616 ENST00000478610 ENST00000494550 ENST00000485077
    ENST00000460988 ENST00000425946 ENST00000444031
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGL2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RGL2 (see all 11):
    hsa-miR-142-3p hsa-miR-328 hsa-miR-27a hsa-miR-324-3p hsa-miR-4255 hsa-miR-128 hsa-miR-3681* hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidRGL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RGL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL2
    Clone
    Products:
         
    OriGene clones in human, mouse for RGL2 (see all 8)
    OriGene ORF clones in mouse, rat for RGL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGL2 (NM_004761)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL2
    Sirion Biotech Customized lentivirus for stable overexpression of RGL2 
                         Customized lentivirus expression plasmids for stable overexpression of RGL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RGL2
    OriGene qSTAR qPCR primer pairs in human, mouse for RGL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL2

    Additional mRNA sequence: 

    AK095967.1 AL050259.1 BC000316.1 BC005037.1 BC032681.1 BX648015.1 D85757.1 U68142.1 

    23 DOTS entries:

    DT.99998208  DT.318123  DT.91809717  DT.121364717  DT.95340907  DT.99947740  DT.75124524  DT.95340908 
    DT.100789247  DT.121364627  DT.100728258  DT.100789254  DT.95340990  DT.100709336  DT.100789249  DT.100789250 
    DT.100789253  DT.97781926  DT.100029308  DT.100760268  DT.121364598  DT.121364720  DT.80100030 

    24/315 AceView cDNA sequences (see all 315):

    BQ884252 AA526375 BQ955127 AA687824 CA417539 AA458470 BU902962 CF125267 
    BC005037 BU785457 CB215713 BP361069 BM792732 NM_004761 AA987257 AI312894 
    CF125706 BQ679408 AI401093 BQ011541 BX648015 AA639686 AU116799 AK095967 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGL2 expression in normal human tissues (normalized intensities)      RGL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGGCCAA
    RGL2 Expression
    About this image


    RGL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See RGL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGL2

    SOURCE GeneReport for Unigene cluster: Hs.509622
        SABiosciences Custom PCR Arrays for RGL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RGL2
    OriGene qSTAR qPCR primer pairs in human, mouse for RGL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGL2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgl21 , 5 ral guanine nucleotide dissociation stimulator-like more1, 5 87.47(n)1
    89.96(a)1
      17 (17.98 cM)5
    197321  NM_009059.21  NP_033085.21 
     339295435 
    lizard
    (Anolis carolinensis)
    Reptilia RGL26
    --
    --
    50(a)
    25(a)
    1 ↔ 1
    possible ortholog
    GL343733.1(239737-277159)
    GL344486.1(4270-15739)
    zebrafish
    (Danio rerio)
    Actinopterygii rgl21 ral guanine nucleotide dissociation stimulator-like more 52.96(n)
    46.69(a)
      65227  NM_001115093.2  NP_001108565.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgl6
    Ral guanine nucleotide exchange factor
    20(a)
    1 → many
    3L(13899997-13918435)
    worm
    (Caenorhabditis elegans)
    Secernentea rgl-16
    Protein RGL-1, isoform a
    20(a)
    1 → many
    X(3210473-3220369)


    ENSEMBL Gene Tree for RGL2 (if available)
    TreeFam Gene Tree for RGL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGL2 gene
    RALGPS22  RAPGEF12  RASGRF12  SOS22  RASGRF22  SOS12  RGL32  RALGDS2  
    RALGPS12  RGL42  RGL12  
    9 SIMAP similar genes for RGL2 using alignment to 8 protein entries:     RGL2_HUMAN (see all proteins):
    HKE1.5    FLJ00371    FLJ00185    RALGDS    FLJ00153    RGL4
    DKFZp686C2469    RGL3    RGL1

    RGL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 SNPs in RGL2 are shown (see all 224)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894287171,2
    --33259491(+) CCCCCA/CGAGTG 2 -- ut310--------
    rs18018231,2
    C,F,A,H--33259582(-) ACATGC/TAAGGG 2 -- ut3113Minor allele frequency- T:0.03NA NS EA WA 1444
    rs1825199221,2
    --33259601(+) GGCCAA/CGAATC 2 -- ut310--------
    rs1858623251,2
    --33259619(+) GATGCA/GTTTTT 2 -- ut310--------
    rs77540651,2
    C,H--33259626(+) TTTTCC/GAGCAC 2 -- ut314Minor allele frequency- G:0.00NS EA 420
    rs1909269401,2
    --33259659(+) AAGGTG/TGGAAG 2 -- ut310--------
    rs2013152421,2
    C--33259866(+) GCCAAC/TGGGGC 2 -- ut311Minor allele frequency- T:0.00EU 979
    rs2006907431,2
    C--33259872(+) GGGGCG/TTCCTC 2 -- ut310--------
    rs1481511951,2
    C,F--33259903(+) ATCTTC/TCTCCC 4 R syn12Minor allele frequency- T:0.00NA EU 5793
    rs1159950161,2
    C,F--33259909(+) CTCCCT/CGTGGC 4 /T syn12Minor allele frequency- C:0.00WA NA 4766

    HapMap Linkage Disequilibrium report for RGL2 (33259431 - 33267176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    nsv830635CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RGL2
    DNA2.0 Custom Variant and Variant Library Synthesis for RGL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602306    OMIM disorders: --

    7 diseases for RGL2:    About MalaCards
    normophosphatemic familial tumoral calcinosis    familial tumoral calcinosis    calcinosis    systemic lupus erythematosus
    lupus erythematosus    pancreatic cancer    pancreatitis


    RGL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGL2
    Human Genome Epidemiology (HuGE) Navigator: RGL2 (2 documents)

    Export disorders for RGL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGL2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with RGL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS. (PubMed id 8976381)1, 2, 3 Isomura M.... Nakamura Y. (1996)
    2. Functional characterization of SAMD9, a protein defic ient in normophosphatemic familial tumoral calcinosis. (PubMed id 21160498)1, 2 Hershkovitz D....Sprecher E. (2011)
    3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)1, 2 Herberg J.A.... Trowsdale J. (1998)
    7. G-protein binding features and regulation of the RalGDS family member, RGL2. (PubMed id 18540861)1, 9 Ferro E....Trabalzini L. (2008)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5863 HGNC: 9769 AceView: RGL2 Ensembl:ENSG00000237441 euGenes: HUgn5863
    ECgene: RGL2 H-InvDB: RGL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGL2 gene:
    Search GeneIP for patents involving RGL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RGL2  
     OriGene qPCR primer pairs and template standards for RGL2   OriGene Protein Over-expression Lysate for RGL2  
     OriGene MassSpec something-or-other for RGL2   OriGene clones in human, mouse for RGL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RGL2   OriGene Purified Protein for RGL2  
     OriGene ORF clones in mouse, rat for RGL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RGL2   OriGene Custom Protein Services for RGL2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGL2
     QIAGEN SeqTarget long-range PCR primers for resequencing RGL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL2
     GenScript Custom Purified and Recombinant Proteins Services for RGL2 GenScript cDNA clones with any tag delivered in your preferred vector for RGL2
     GenScript Custom Assay Services for RGL2 GenScript Custom Superior Antibodies Services for RGL2
     GenScript Custom overexpressing Cell Line Services for RGL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RGL2 promoter
     Search Chromatin IP Primers for RGL2
     RT2 qPCR Primer Assay in human, mouse, rat RGL2
     Search GNC Networks for RGL2
     SABiosciences Custom PCR Arrays for RGL2
     Search Tocris compounds for RGL2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RGL2 antibodies
     RGL2 proteins
     RGL2 lysates
     Antibodies for RGL2
     See all of Abcam's Antibodies, Kits and Proteins for RGL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RGL2
     Antibodies for RGL2
     ELISAs for RGL2
     CLIAs for RGL2
     Search LifeMap BioReagents cell lines for RGL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL2
     SwitchGear 3'UTR luciferase reporter plasmids for RGL2
     SwitchGear Promoter luciferase reporter plasmids for RGL2
     ThermoFisher Antibodies for RGL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RGL2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGL2
    Customized:
     lentivirus for stable overexpression of RGL2
     lentivirus expression plasmids for stable overexpression of RGL2
     adenovirus for overexpression of RGL2
     LSBio Antibodies in human, mouse, rat for RGL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RGL2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4