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Aliases for RGL2 Gene

Aliases for RGL2 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 2 2 3
  • Ras-Associated Protein RAB2L 3 4
  • RalGDS-Like Factor 3 4
  • RalGDS-Like 2 3 4
  • RAB2L 3 4
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 2 5
  • RAB2, Member RAS Oncogene Family-Like 2
  • GDS-Related Protein 3
  • HKE1.5 3
  • KE1.5 3

External Ids for RGL2 Gene

Previous HGNC Symbols for RGL2 Gene

  • RAB2L

Previous GeneCards Identifiers for RGL2 Gene

  • GC06M033307
  • GC06M033367
  • GC06M033259
  • GC06M033001

Summaries for RGL2 Gene

GeneCards Summary for RGL2 Gene

RGL2 (Ral Guanine Nucleotide Dissociation Stimulator Like 2) is a Protein Coding gene. Diseases associated with RGL2 include familial tumoral calcinosis and calcinosis. Among its related pathways are Ras signaling pathway and Cytoskeleton remodeling_RalA regulation pathway. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RGL2 Gene

  • Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).

Gene Wiki entry for RGL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL2 Gene

Genomics for RGL2 Gene

Regulatory Elements for RGL2 Gene

Promoters for RGL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGL2 Gene

Chromosome:
6
Start:
33,291,654 bp from pter
End:
33,299,452 bp from pter
Size:
7,799 bases
Orientation:
Minus strand

Genomic View for RGL2 Gene

Genes around RGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RGL2 Gene

  • Protein details for RGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15211-RGL2_HUMAN
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 2
    Protein Accession:
    O15211
    Secondary Accessions:
    • B4DG72
    • Q5STK0
    • Q9Y3F3

    Protein attributes for RGL2 Gene

    Size:
    777 amino acids
    Molecular mass:
    83549 Da
    Quaternary structure:
    • Interacts with SAMD9.

    Alternative splice isoforms for RGL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGL2 Gene

Proteomics data for RGL2 Gene at MOPED

Post-translational modifications for RGL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RGL2 Gene

Domains & Families for RGL2 Gene

Graphical View of Domain Structure for InterPro Entry

O15211

UniProtKB/Swiss-Prot:

RGL2_HUMAN :
  • Contains 1 N-terminal Ras-GEF domain.
Domain:
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RGL2: view

No data available for Gene Families for RGL2 Gene

Function for RGL2 Gene

Molecular function for RGL2 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
genes like me logo Genes that share phenotypes with RGL2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGL2 Gene

Localization for RGL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGL2 Gene COMPARTMENTS Subcellular localization image for RGL2 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RGL2 Gene

Pathways & Interactions for RGL2 Gene

genes like me logo Genes that share pathways with RGL2: view

Pathways by source for RGL2 Gene

1 GeneTex pathway for RGL2 Gene
1 KEGG pathway for RGL2 Gene

Gene Ontology (GO) - Biological Process for RGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity NAS 8976381
genes like me logo Genes that share ontologies with RGL2: view

No data available for SIGNOR curated interactions for RGL2 Gene

Drugs & Compounds for RGL2 Gene

(3) Drugs for RGL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGL2: view

Transcripts for RGL2 Gene

Unigene Clusters for RGL2 Gene

Ral guanine nucleotide dissociation stimulator-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGL2 Gene

No ASD Table

Relevant External Links for RGL2 Gene

GeneLoc Exon Structure for
RGL2
ECgene alternative splicing isoforms for
RGL2

Expression for RGL2 Gene

mRNA expression in normal human tissues for RGL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RGL2 Gene

This gene is overexpressed in Heart (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGL2 Gene



SOURCE GeneReport for Unigene cluster for RGL2 Gene Hs.509622

genes like me logo Genes that share expression patterns with RGL2: view

Protein tissue co-expression partners for RGL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGL2 Gene

Orthologs for RGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGL2 35
  • 99.61 (n)
  • 99.36 (a)
RGL2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGL2 36
  • 90 (a)
OneToOne
RGL2 35
  • 89.53 (n)
  • 90.09 (a)
dog
(Canis familiaris)
Mammalia RGL2 35
  • 91.29 (n)
  • 92.66 (a)
RGL2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgl2 16
Rgl2 35
  • 87.31 (n)
  • 89.83 (a)
Rgl2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGL2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rgl2 35
  • 87.44 (n)
  • 89.7 (a)
lizard
(Anolis carolinensis)
Reptilia RGL2 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgl2 35
  • 51.84 (n)
  • 45.71 (a)
zebrafish
(Danio rerio)
Actinopterygii rgl2 36
  • 42 (a)
OneToOne
rgl2 35
  • 52.86 (n)
  • 46.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rgl 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgl-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for RGL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGL2 Gene

ENSEMBL:
Gene Tree for RGL2 (if available)
TreeFam:
Gene Tree for RGL2 (if available)

Paralogs for RGL2 Gene

genes like me logo Genes that share paralogs with RGL2: view

Variants for RGL2 Gene

Sequence variations from dbSNP and Humsavar for RGL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs34022110 - 33,293,230(+) GGCTG(A/G)GGTCA nc-transcript-variant, downstream-variant-500B, reference, missense
rs35273540 - 33,292,438(+) GCTCC(C/T)CTGGT reference, missense
rs1801823 -- 33,291,805(-) ACATG(C/T)AAGGG utr-variant-3-prime
rs2239842 -- 33,294,094(-) GGAAC(C/T)TTCAC intron-variant
rs7754065 -- 33,291,849(+) TTTTC(C/G)AGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RGL2 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv830635 CNV Loss 17160897

Variation tolerance for RGL2 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.84; 79.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGL2 Gene

HapMap Linkage Disequilibrium report
RGL2
Human Gene Mutation Database (HGMD)
RGL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL2 Gene

Disorders for RGL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
familial tumoral calcinosis
calcinosis
  • pathologic calcification
- elite association - COSMIC cancer census association via MalaCards
Search RGL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGL2

Genetic Association Database (GAD)
RGL2
Human Genome Epidemiology (HuGE) Navigator
RGL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGL2
genes like me logo Genes that share disorders with RGL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGL2 Gene

Publications for RGL2 Gene

  1. Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS. (PMID: 8976381) Isomura M. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4 67
  2. G-protein binding features and regulation of the RalGDS family member, RGL2. (PMID: 18540861) Ferro E. … Trabalzini L. (Biochem. J. 2008) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for RGL2 Gene

Sources for RGL2 Gene

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