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Aliases for RGL1 Gene

Aliases for RGL1 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 1 2 3
  • RalGDS-Like 1 3 4
  • RGL 3 4
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 1 5
  • KIAA0959 4

External Ids for RGL1 Gene

Previous GeneCards Identifiers for RGL1 Gene

  • GC01P180845
  • GC01P180336
  • GC01P181871
  • GC01P183605
  • GC01P154841

Summaries for RGL1 Gene

GeneCards Summary for RGL1 Gene

RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1) is a Protein Coding gene. Diseases associated with RGL1 include Nutritional Optic Neuropathy and Toxic Optic Neuropathy. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RGL1 Gene

  • Probable guanine nucleotide exchange factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL1 Gene

Genomics for RGL1 Gene

Regulatory Elements for RGL1 Gene

Enhancers for RGL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGL1 Gene

183,636,047 bp from pter
183,928,551 bp from pter
292,505 bases
Plus strand

Genomic View for RGL1 Gene

Genes around RGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL1 Gene

Proteins for RGL1 Gene

  • Protein details for RGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 1
    Protein Accession:
    Secondary Accessions:
    • Q5SXQ2
    • Q5SXQ6
    • Q9HBY3
    • Q9HBY4
    • Q9NZL5
    • Q9UG43
    • Q9Y2G6

    Protein attributes for RGL1 Gene

    768 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    • Interacts with Ras.
    • Sequence=BAA76803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL1 Gene


neXtProt entry for RGL1 Gene

Proteomics data for RGL1 Gene at MOPED

Post-translational modifications for RGL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGL1 Gene

No data available for DME Specific Peptides for RGL1 Gene

Domains & Families for RGL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RGL1: view

No data available for Gene Families for RGL1 Gene

Function for RGL1 Gene

Molecular function for RGL1 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor.
genes like me logo Genes that share phenotypes with RGL1: view

Animal Model Products

miRNA for RGL1 Gene

miRTarBase miRNAs that target RGL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGL1 Gene

Localization for RGL1 Gene

Subcellular locations from

Jensen Localization Image for RGL1 Gene COMPARTMENTS Subcellular localization image for RGL1 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RGL1 Gene

Pathways & Interactions for RGL1 Gene

genes like me logo Genes that share pathways with RGL1: view

Gene Ontology (GO) - Biological Process for RGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with RGL1: view

No data available for SIGNOR curated interactions for RGL1 Gene

Drugs & Compounds for RGL1 Gene

(3) Drugs for RGL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for RGL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGL1: view

Transcripts for RGL1 Gene

Unigene Clusters for RGL1 Gene

Ral guanine nucleotide dissociation stimulator-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -

Relevant External Links for RGL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGL1 Gene

mRNA expression in normal human tissues for RGL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RGL1 Gene

This gene is overexpressed in Blymphocyte (53.5) and Gallbladder (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGL1 Gene

SOURCE GeneReport for Unigene cluster for RGL1 Gene Hs.497148

mRNA Expression by UniProt/SwissProt for RGL1 Gene

Tissue specificity: Expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis.
genes like me logo Genes that share expression patterns with RGL1: view

Protein tissue co-expression partners for RGL1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for RGL1 Gene

Orthologs for RGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RGL1 35
  • 92.28 (n)
  • 95.89 (a)
RGL1 36
  • 96 (a)
(Canis familiaris)
Mammalia RGL1 35
  • 93.57 (n)
  • 96.39 (a)
RGL1 36
  • 96 (a)
(Mus musculus)
Mammalia Rgl1 35
  • 89.86 (n)
  • 95.13 (a)
Rgl1 16
Rgl1 36
  • 94 (a)
(Pan troglodytes)
Mammalia RGL1 35
  • 97.14 (n)
  • 96.35 (a)
RGL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rgl1 35
  • 89.01 (n)
  • 93.25 (a)
(Monodelphis domestica)
Mammalia RGL1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RGL1 36
  • 82 (a)
(Gallus gallus)
Aves RGL1 35
  • 81.56 (n)
  • 88.47 (a)
RGL1 36
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
-- 36
  • 60 (a)
(Danio rerio)
Actinopterygii rgl1 35
  • 66.53 (n)
  • 68.49 (a)
rgl1 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010782 35
  • 47.22 (n)
  • 40.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rgl 35
  • 48.37 (n)
  • 41.38 (a)
Rgl 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea rgl-1 35
  • 46.52 (n)
  • 38.06 (a)
rgl-1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for RGL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGL1 Gene

Gene Tree for RGL1 (if available)
Gene Tree for RGL1 (if available)

Paralogs for RGL1 Gene

(10) SIMAP similar genes for RGL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGL1: view

Variants for RGL1 Gene

Sequence variations from dbSNP and Humsavar for RGL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035823 A breast cancer sample
VAR_035824 A breast cancer sample
rs4650 -- 183,927,827(+) TTTTC(C/T)TAATC utr-variant-3-prime
rs766721 -- 183,792,176(-) ACAAA(A/C)AAAAA intron-variant
rs1112003 -- 183,759,719(-) CAACA(A/C)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGL1 Gene

Variant ID Type Subtype PubMed ID
nsv872582 CNV Loss 21882294
nsv832015 CNV Gain 17160897
nsv825598 CNV Gain 20364138
esv259706 OTHER Complex 20981092
nsv441723 CNV CNV 18776908
nsv832026 CNV Gain+Loss 17160897
esv2720140 CNV Deletion 23290073
nsv525878 CNV Gain 19592680
esv1709028 CNV Insertion 17803354

Variation tolerance for RGL1 Gene

Residual Variation Intolerance Score: 6.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGL1 Gene

Disorders for RGL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nutritional optic neuropathy
toxic optic neuropathy
  • toxic optic neuropathy [ambiguous]
- elite association - COSMIC cancer census association via MalaCards
Search RGL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RGL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGL1 Gene

Publications for RGL1 Gene

  1. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. (PMID: 10760592) Sood R. … Bonner T.I. (Biochim. Biophys. Acta 2000) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3
  3. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W. … Lau Y.L. (Am. J. Hum. Genet. 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R. … McGuffin P. (Am J Psychiatry 2010) 3

Products for RGL1 Gene

Sources for RGL1 Gene