Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGL1 Gene

protein-coding   GIFtS: 58
GCID: GC01P183605

Ral Guanine Nucleotide Dissociation Stimulator-Like 1

  Search for RGL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ral Guanine Nucleotide Dissociation Stimulator-Like 11 2
RGL2 3 5
RalGDS-Like 12 3
KIAA09593

External Ids:    HGNC: 302811   Entrez Gene: 231792   Ensembl: ENSG000001433447   OMIM: 6056675   UniProtKB: Q9NZL63   

Export aliases for RGL1 gene to outside databases

Previous GC identifers: GC01P180845 GC01P180336 GC01P181871 GC01P154841


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RGL1 Gene: 
RGL1 (ral guanine nucleotide dissociation stimulator-like 1) is a protein-coding gene. Among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolic pathways. GO annotations related to this gene include Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
Function: Probable guanine nucleotide exchange factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGL1 gene promoter:
         AhR   AML1a   Cdc5   NF-AT   C/EBPalpha   Arnt   NF-AT4   NF-AT2   NF-AT1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.2

RGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P183605:  view genomic region     (about GC identifiers)

Start:
183,605,208 bp from pter      End:
183,897,666 bp from pter
Size:
292,459 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6 (See protein sequence)
Recommended Name: Ral guanine nucleotide dissociation stimulator-like 1  
Size: 768 amino acids; 86701 Da
Subunit: Interacts with Ras (By similarity)
Sequence caution: Sequence=BAA76803.1; Type=Erroneous initiation;
Secondary accessions: Q5SXQ2 Q5SXQ6 Q9HBY3 Q9HBY4 Q9NZL5 Q9UG43 Q9Y2G6
Alternative splicing: 2 isoforms:  Q9NZL6-1   Q9NZL6-2   

Explore the universe of human proteins at neXtProt for RGL1: NX_Q9NZL6

Explore proteomics data for RGL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZL6

  • RGL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGL1 Protein Expression
    REFSEQ proteins: NP_055964.3  
    ENSEMBL proteins: 
     ENSP00000356501   ENSP00000354097   ENSP00000303192   ENSP00000438662   ENSP00000437355  
    Reactome Protein details: Q9NZL6
    Human Recombinant Protein Products for RGL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RGL1
    GenScript Custom Purified and Recombinant Proteins Services for RGL1
    Novus Biologicals RGL1 Proteins
    Novus Biologicals RGL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RGL1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    RGL1 for ontologies           About GeneDecksing



    RGL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RGL1
    GenScript Custom Superior Antibodies Services for RGL1
    Novus Biologicals RGL1 Antibodies
    Abcam antibodies for RGL1
    Cloud-Clone Corp. Antibodies for RGL1 
    Search ThermoFisher Antibodies for RGL1
    LSBio Antibodies in human, mouse, rat for RGL1 

    Assay Products for RGL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RGL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RGL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RGL1 
    Cloud-Clone Corp. CLIAs for RGL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc
     IPR019804 Ras_G-nucl-exch_fac_CS

    Graphical View of Domain Structure for InterPro Entry Q9NZL6

    ProtoNet protein and cluster: Q9NZL6

    2 Blocks protein domains:
    IPB000159 RA domain
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    RGL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGL1_HUMAN, Q9NZL6
    Function: Probable guanine nucleotide exchange factor

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0008321Ral guanyl-nucleotide exchange factor activity NAS10760592
         
    RGL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGL1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGL1
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate RGL1 (see all 75):
    hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-4305 hsa-miR-30d hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidRGL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RGL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RGL1
    Sirion Biotech Customized adenovirus for overexpression of RGL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RGL1 (see all 6)
    OriGene ORF clones in mouse, rat for RGL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGL1 (NM_015149)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL1
    Sirion Biotech Customized lentivirus for stable overexpression of RGL1 
                         Customized lentivirus expression plasmids for stable overexpression of RGL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RGL1
    Search LifeMap BioReagents cell lines for RGL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3G-protein signaling K-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway0.96
    4G-protein signaling N-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway0.83
    5Cytoskeleton remodeling RalA regulation pathway
    Cytoskeleton remodeling RalA regulation pathway1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for RGL1
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway


    3 GeneGo (Thomson Reuters) Pathways for RGL1
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway

    5        Reactome Pathways for RGL1
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    PPARA Activates Gene Expression
    Fatty acid, triacylglycerol, and ketone body metabolism
    Metabolism of lipids and lipoproteins



    RGL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for RGL1 (Q9NZL63 ENSP000003031924) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=9 STRING: ENSP00000309845
    RIT2Q995783, ENSP000003218054I2D: score=1 STRING: ENSP00000321805
    RIT1Q929633, ENSP000003573064I2D: score=3 STRING: ENSP00000357306
    CARM1ENSP000003256904STRING: ENSP00000325690
    CHD9ENSP000003815224STRING: ENSP00000381522
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction NAS10760592
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0051056regulation of small GTPase mediated signal transduction IEA--

    RGL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGL1

    3 HMDB Compounds for RGL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for RGL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 58.5 3 9891982 (1), 11856330 (1), 10760592 (1)

    Search CenterWatch for drugs/clinical trials and news about RGL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGL1 gene: 
    NM_015149.3  

    Unigene Cluster for RGL1:

    Ral guanine nucleotide dissociation stimulator-like 1
    Hs.497148  [show with all ESTs]
    Unigene Representative Sequence: NM_015149
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367531 ENST00000360851(uc001gqo.3 uc010poi.2) ENST00000304685(uc010pof.1 uc001gqm.3 uc010pog.2 uc010poh.2)
    ENST00000536277 ENST00000539189
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGL1
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate RGL1 (see all 75):
    hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-4305 hsa-miR-30d hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidRGL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RGL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL1
    Clone
    Products:
         
    OriGene clones in human, mouse for RGL1 (see all 6)
    OriGene ORF clones in mouse, rat for RGL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGL1 (NM_015149)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL1
    Sirion Biotech Customized lentivirus for stable overexpression of RGL1 
                         Customized lentivirus expression plasmids for stable overexpression of RGL1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RGL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RGL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL1

    Additional mRNA sequence: 

    AB023176.1 AF186779.1 AF186780.1 AK295179.1 AK295611.1 AK304293.1 AK309237.1 AK311701.1 
    AK311716.1 AK316526.1 AL080117.1 BC039250.1 BC136591.1 BX537416.1 

    14 DOTS entries:

    DT.100752130  DT.100645770  DT.95364389  DT.100050607  DT.121440051  DT.121439979  DT.75100513  DT.91865357 
    DT.121440012  DT.121440068  DT.307648  DT.100855250  DT.121440053  DT.97860336 

    24/131 AceView cDNA sequences (see all 131):

    AI147998 BM979901 AA152068 AI056497 BQ008743 AA341627 AF186779 BX094860 
    BF445808 AA703533 AB023176 AI142287 BU838668 AI183474 BX474709 BM696476 
    BE763781 AA485825 AA377178 Z45099 AI686146 CD671776 BQ774305 BM718611 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RGL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:              -                 -                                                                                                         
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for RGL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGL1 expression in normal human tissues (normalized intensities)      RGL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCCAGA
    RGL1 Expression
    About this image


    RGL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Adipose (Muscoskeletal System)
             epididymal fat pads   
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Lung (Respiratory System)

    See RGL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGL1

    SOURCE GeneReport for Unigene cluster: Hs.497148

    UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
    Tissue specificity: Expressed in a wide variety of tissues with strong expression being seen in the heart, brain,
    kidney, spleen and testis

        SABiosciences Custom PCR Arrays for RGL1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RGL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RGL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGL1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgl11 , 5 ral guanine nucleotide dissociation stimulator,-like more1, 5 89.86(n)1
    95.13(a)1
      1 (64.85 cM)5
    197311  NM_016846.31  NP_058542.21 
     1525167595 
    chicken
    (Gallus gallus)
    Aves RGL11 ral guanine nucleotide dissociation stimulator-like more 81.56(n)
    88.47(a)
      424446  NM_001031271.1  NP_001026442.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    72(a)
    66(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    GL343203.1(3886091-3923940)
    GL344486.1(4270-15739)
    zebrafish
    (Danio rerio)
    Actinopterygii rgl11 ral guanine nucleotide dissociation stimulator-like more 66.76(n)
    68.76(a)
      402933  NM_205637.1  NP_991200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgl1 Ral guanine nucleotide exchange factor 47.9(n)
    41.67(a)
      44115  NM_079958.2  NP_524697.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rgl-11 Protein RGL-1 46.72(n)
    39.22(a)
      180611  NM_076149.3  NP_508550.1 


    ENSEMBL Gene Tree for RGL1 (if available)
    TreeFam Gene Tree for RGL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGL1 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  RASGRF22  SOS12  RGL32  
    RALGDS2  RALGPS12  RGL42  
    10 SIMAP similar genes for RGL1 using alignment to 3 protein entries:     RGL1_HUMAN (see all proteins):
    DKFZp686C2469    HKE1.5    FLJ00371    RALGDS    RGL4    DKFZp781H1715
    FLJ00185    FLJ00153    RGL3    RGL2

    RGL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5416 SNPs in RGL1 are shown (see all 5416)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358244
    A breast cancer sample4--see VAR_0358242 V M mis40--------
    VAR_0358234
    A breast cancer sample4--see VAR_0358232 Y S mis40--------
    rs1930901721,2
    Cuntested1183896812(+) GCCATA/G/TTGTGG 1 -- ut310--------
    rs1406528051,2
    C--183607107(+) TAAAGG/TTGATT 1 -- int10--------
    rs1447244531,2
    --183607159(+) AAAATC/TGAACA 1 -- int10--------
    rs1932131751,2
    --183607183(+) TGACAA/GCAAAT 1 -- int10--------
    rs747209941,2
    C,F--183607214(+) TAATAT/CATCTC 1 -- int13Minor allele frequency- C:0.09WA NA EA 358
    rs1855128271,2
    --183607302(+) TCCCAG/TAGTAG 1 -- int10--------
    rs1163116801,2
    C,F--183607348(+) TAATCG/AATTGC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1908180151,2
    --183607362(+) AGGGTA/GTAATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RGL1 (183605208 - 183855208 bp, first 250kb of RGL1)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RGL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720140CNV Deletion23290073
    esv1709028CNV Insertion17803354
    nsv872582CNV Loss21882294
    nsv825598CNV Gain20364138
    nsv832015CNV Gain17160897
    nsv525878CNV Gain19592680
    nsv832026CNV Gain+Loss17160897
    nsv441723CNV CNV18776908
    esv259706OTHER Complex20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RGL1
    DNA2.0 Custom Variant and Variant Library Synthesis for RGL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RGL1 for disorders           About MalaCards
    OMIM gene information: 605667    OMIM disorders: --


    RGL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGL1
    Human Genome Epidemiology (HuGE) Navigator: RGL1 (3 documents)

    Export disorders for RGL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGL1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with RGL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. (PubMed id 10760592)1, 2, 3, 9 Sood R....Bonner T.I. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. Genome-wide pharmacogenetics of antidepressant respon se in the GENDEP project. (PubMed id 20360315)1, 4 Uher R....McGuffin P. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (2008)
    6. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lup us erythematosus in Asians. (PubMed id 23273568)1 Yang W....Lau Y.L. (2013)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23179 HGNC: 30281 AceView: RGL1 Ensembl:ENSG00000143344 euGenes: HUgn23179
    ECgene: RGL1 H-InvDB: RGL1

    (According to HUGE)
    About This Section
    HUGE: KIAA0959

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGL1 gene:
    Search GeneIP for patents involving RGL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RGL1  
     OriGene qPCR primer pairs and template standards for RGL1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RGL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RGL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RGL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RGL1   OriGene Custom Protein Services for RGL1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGL1
     QIAGEN SeqTarget long-range PCR primers for resequencing RGL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGL1
     GenScript Custom Purified and Recombinant Proteins Services for RGL1 GenScript cDNA clones with any tag delivered in your preferred vector for RGL1
     GenScript Custom Assay Services for RGL1 GenScript Custom Superior Antibodies Services for RGL1
     GenScript Custom overexpressing Cell Line Services for RGL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RGL1 promoter
     Search Chromatin IP Primers for RGL1
     RT2 qPCR Primer Assay in human, mouse, rat RGL1
     Search GNC Networks for RGL1
     SABiosciences Custom PCR Arrays for RGL1
     Search Tocris compounds for RGL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RGL1 antibodies
     RGL1 proteins
     RGL1 lysates
     Antibodies for RGL1
     See all of Abcam's Antibodies, Kits and Proteins for RGL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RGL1
     Antibodies for RGL1
     ELISAs for RGL1
     CLIAs for RGL1
     Search LifeMap BioReagents cell lines for RGL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL1
     SwitchGear 3'UTR luciferase reporter plasmids for RGL1
     SwitchGear Promoter luciferase reporter plasmids for RGL1
     Search ThermoFisher Antibodies for RGL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RGL1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGL1
    Customized:
     lentivirus for stable overexpression of RGL1
     lentivirus expression plasmids for stable overexpression of RGL1
     adenovirus for overexpression of RGL1
     LSBio Antibodies in human, mouse, rat for RGL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RGL1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4