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RGL1 Gene

protein-coding   GIFtS: 59
GCID: GC01P183605

Ral Guanine Nucleotide Dissociation Stimulator-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ral Guanine Nucleotide Dissociation Stimulator-Like 11 2
RGL2 3 5
RalGDS-Like 12 3
KIAA09593

External Ids:    HGNC: 302811   Entrez Gene: 231792   Ensembl: ENSG000001433447   OMIM: 6056675   UniProtKB: Q9NZL63   

Export aliases for RGL1 gene to outside databases

Previous GC identifers: GC01P180845 GC01P180336 GC01P181871 GC01P154841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RGL1 Gene:
RGL1 (ral guanine nucleotide dissociation stimulator-like 1) is a protein-coding gene. GO annotations related to this gene include Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
Function: Probable guanine nucleotide exchange factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGL1 gene promoter:
         AhR   AML1a   Cdc5   NF-AT   C/EBPalpha   Arnt   NF-AT4   NF-AT2   NF-AT1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGL1 promoter sequence
   Search Chromatin IP Primers for RGL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.2

RGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P183605:  view genomic region     (about GC identifiers)

Start:
183,605,208 bp from pter      End:
183,897,666 bp from pter
Size:
292,459 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6 (See protein sequence)
Recommended Name: Ral guanine nucleotide dissociation stimulator-like 1  
Size: 768 amino acids; 86701 Da
Subunit: Interacts with Ras (By similarity)
Sequence caution: Sequence=BAA76803.1; Type=Erroneous initiation;
Secondary accessions: Q5SXQ2 Q5SXQ6 Q9HBY3 Q9HBY4 Q9NZL5 Q9UG43 Q9Y2G6
Alternative splicing: 2 isoforms:  Q9NZL6-1   Q9NZL6-2   

Explore the universe of human proteins at neXtProt for RGL1: NX_Q9NZL6

Explore proteomics data for RGL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055964.3  
    ENSEMBL proteins: 
     ENSP00000303192   ENSP00000354097   ENSP00000438662   ENSP00000437355  
    Reactome Protein details: Q9NZL6

    RGL1 Human Recombinant Protein Products:

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    Novus Biologicals RGL1 Proteins
    Novus Biologicals RGL1 Lysates
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RGL1

     
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    antibodies-online proteins for RGL1 (4 products) 

     
    antibodies-online peptides for RGL1

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    antibodies-online antibodies for RGL1 (16 products) 

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    Cloud-Clone Corp. ELISAs for RGL1
    Cloud-Clone Corp. CLIAs for RGL1
    Search eBioscience for ELISAs for RGL1 
    antibodies-online kits for RGL1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc
     IPR019804 Ras_G-nucl-exch_fac_CS

    Graphical View of Domain Structure for InterPro Entry Q9NZL6

    ProtoNet protein and cluster: Q9NZL6

    2 Blocks protein domains:
    IPB000159 RA domain
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    Find genes that share domains with RGL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGL1_HUMAN, Q9NZL6
    Function: Probable guanine nucleotide exchange factor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0008321Ral guanyl-nucleotide exchange factor activity NAS10760592
         
    Find genes that share ontologies with RGL1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RGL1

    miRNA
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    Block miRNA regulation of human, mouse, rat RGL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGL1 (see all 75):
    hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-4305 hsa-miR-30d hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidRGL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RGL1
    Predesigned siRNA for gene silencing in human, mouse, rat RGL1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RGL1 (see all 8)
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    GenScript: all cDNA clones in your preferred vector: RGL1 (NM_015149)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RGL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGL1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Immune response Antigen presentation by MHC class II
    G protein signaling N RAS regulation pathway0.46
    4Ras signaling pathway
    Ras signaling pathway0.36
    5G protein signaling K RAS regulation pathway
    G protein signaling K RAS regulation pathway


    Find genes that share SuperPaths with RGL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for RGL1
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway

    1 Reactome Pathway for RGL1
        PPARA activates gene expression


    1 Kegg Pathway  (Kegg details for RGL1):
        Ras signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGL1
    Interactions:

        Search GeneGlobe Interaction Network for RGL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for RGL1 (Q9NZL63 ENSP000003031924) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=9 STRING: ENSP00000309845
    RIT2Q995783, ENSP000003218054I2D: score=1 STRING: ENSP00000321805
    RIT1Q929633, ENSP000003573064I2D: score=3 STRING: ENSP00000357306
    CARM1ENSP000003256904STRING: ENSP00000325690
    CHD9ENSP000003815224STRING: ENSP00000381522
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction NAS10760592
    GO:0032315regulation of Ral GTPase activity NAS10760592
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with RGL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGL1

    3 HMDB Compounds for RGL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for RGL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 58.5 3 9891982 (1), 11856330 (1), 10760592 (1)



    Find genes that share compounds with RGL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGL1 gene: 
    NM_015149.3  

    Unigene Cluster for RGL1:

    Ral guanine nucleotide dissociation stimulator-like 1
    Hs.497148  [show with all ESTs]
    Unigene Representative Sequence: NM_015149
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304685(uc010pof.1 uc001gqm.3 uc010pog.2 uc010poh.2)
    ENST00000360851(uc001gqo.3 uc010poi.2) ENST00000536277 ENST00000539189

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RGL1 (see all 75):
    hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-4305 hsa-miR-30d hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidRGL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RGL1
    Clone
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    OriGene ORF clones in mouse, rat for RGL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGL1 (NM_015149)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGL1
    Primer
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    OriGene qPCR primer pairs and template standards for RGL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RGL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGL1
      QuantiTect SYBR Green Assays in human, mouse, rat RGL1
      QuantiFast Probe-based Assays in human, mouse, rat RGL1

    Additional mRNA sequence: 

    AB023176.1 AF186779.1 AF186780.1 AK295179.1 AK295611.1 AK304293.1 AK309237.1 AK311701.1 
    AK311716.1 AK316526.1 AL080117.1 BC039250.1 BC136591.1 BX537416.1 

    14 DOTS entries:

    DT.100752130  DT.100645770  DT.95364389  DT.100050607  DT.121440051  DT.121439979  DT.75100513  DT.91865357 
    DT.121440012  DT.121440068  DT.307648  DT.100855250  DT.121440053  DT.97860336 

    Selected AceView cDNA sequences (see all 131):

    BQ668740 AI686146 BX474709 BU838668 AI142287 AI183474 BF197850 AI655922 
    AA485825 BU735099 BP349555 BX094860 BI835172 AI826737 BQ774305 AL533189 
    BQ008743 AA341627 AA907367 CA313887 BM718611 CA407199 AI278162 CB215399 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RGL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:              -                 -                                                                                                         
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for RGL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCCAGA
    RGL1 Expression
    About this image


    RGL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    RGL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497148

    UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
    Tissue specificity: Expressed in a wide variety of tissues with strong expression being seen in the heart, brain,
    kidney, spleen and testis

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    QuantiFast Probe-based Assays in human, mouse, rat RGL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgl11 , 5 ral guanine nucleotide dissociation stimulator,-like more1, 5 89.86(n)1
    95.13(a)1
      1 (64.85 cM)5
    197311  NM_016846.31  NP_058542.21 
     1525167595 
    chicken
    (Gallus gallus)
    Aves RGL11 ral guanine nucleotide dissociation stimulator-like more 81.56(n)
    88.47(a)
      424446  NM_001031271.1  NP_001026442.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    72(a)
    60(a)
    1 ↔ many
    1 ↔ many
    GL343203.1(3886091-3923940)
    GL343208.1(4061741-4080818)
    zebrafish
    (Danio rerio)
    Actinopterygii rgl11 ral guanine nucleotide dissociation stimulator-like more 66.53(n)
    68.49(a)
      402933  NM_205637.1  NP_991200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgl1 Ral guanine nucleotide exchange factor 48.37(n)
    41.38(a)
      44115  NM_001274885.1  NP_001261814.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rgl-11 rgl-1 46.52(n)
    38.06(a)
      180611  NM_076149.4  NP_508550.1 


    ENSEMBL Gene Tree for RGL1 (if available)
    TreeFam Gene Tree for RGL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGL1 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  RASGRF22  SOS12  RGL32  
    RALGDS2  RALGPS12  RGL42  
    10 SIMAP similar genes for RGL1 using alignment to 3 protein entries:     RGL1_HUMAN (see all proteins):
    DKFZp686C2469    HKE1.5    FLJ00371    RALGDS    RGL4    DKFZp781H1715
    FLJ00185    FLJ00153    RGL3    RGL2

    Find genes that share paralogs with RGL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGL1 (see all 5416)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358244
    A breast cancer sample4--see VAR_0358242 V M mis40--------
    VAR_0358234
    A breast cancer sample4--see VAR_0358232 Y S mis40--------
    rs1930901721,2
    Cuntested1183896812(+) GCCATA/G/TTGTGG 1 -- ut310--------
    rs1406528051,2
    C--183607107(+) TAAAGG/TTGATT 1 -- int10--------
    rs1447244531,2
    --183607159(+) AAAATC/TGAACA 1 -- int10--------
    rs1932131751,2
    --183607183(+) TGACAA/GCAAAT 1 -- int10--------
    rs747209941,2
    C,F--183607214(+) TAATAT/CATCTC 1 -- int13Minor allele frequency- C:0.09WA NA EA 358
    rs1855128271,2
    --183607302(+) TCCCAG/TAGTAG 1 -- int10--------
    rs1163116801,2
    C,F--183607348(+) TAATCG/AATTGC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1908180151,2
    --183607362(+) AGGGTA/GTAATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RGL1 (183605208 - 183855208 bp, first 250kb of RGL1)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RGL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720140CNV Deletion23290073
    esv1709028CNV Insertion17803354
    nsv872582CNV Loss21882294
    nsv825598CNV Gain20364138
    nsv832015CNV Gain17160897
    nsv525878CNV Gain19592680
    nsv832026CNV Gain+Loss17160897
    nsv441723CNV CNV18776908
    esv259706OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605667    OMIM disorders: --


    Find genes that share disorders with RGL1           About GenesLikeMe

    Genetic Association Database (GAD): RGL1
    Human Genome Epidemiology (HuGE) Navigator: RGL1 (3 documents)

    Export disorders for RGL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGL1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with RGL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. (PubMed id 10760592)1, 2, 3, 9 Sood R....Bonner T.I. (Biochim. Biophys. Acta 2000)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    3. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PubMed id 20360315)1, 4 Uher R....McGuffin P. (Am J Psychiatry 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    6. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PubMed id 23273568)1 Yang W....Lau Y.L. (Am. J. Hum. Genet. 2013)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23179 HGNC: 30281 AceView: RGL1 Ensembl:ENSG00000143344 euGenes: HUgn23179
    ECgene: RGL1 Kegg: 23179 H-InvDB: RGL1

    (According to HUGE)
    About This Section

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    HUGE: KIAA0959

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RGL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RGL1 gene:
    Search GeneIP for patents involving RGL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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