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Aliases for RGL1 Gene

Aliases for RGL1 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator-Like 1 2 3
  • RGL 3 4 6
  • RalGDS-Like 1 3 4
  • KIAA0959 4

External Ids for RGL1 Gene

Previous GeneCards Identifiers for RGL1 Gene

  • GC01P180845
  • GC01P180336
  • GC01P181871
  • GC01P154841

Summaries for RGL1 Gene

GeneCards Summary for RGL1 Gene

RGL1 (Ral Guanine Nucleotide Dissociation Stimulator-Like 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Metabolism. GO annotations related to this gene include Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RGL1 Gene

  • Probable guanine nucleotide exchange factor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL1 Gene

Genomics for RGL1 Gene

Regulatory Elements for RGL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGL1 Gene

183,636,073 bp from pter
183,928,532 bp from pter
292,460 bases
Plus strand

Genomic View for RGL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL1 Gene

Proteins for RGL1 Gene

  • Protein details for RGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 1
    Protein Accession:
    Secondary Accessions:
    • Q5SXQ2
    • Q5SXQ6
    • Q9HBY3
    • Q9HBY4
    • Q9NZL5
    • Q9UG43
    • Q9Y2G6

    Protein attributes for RGL1 Gene

    768 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    • Interacts with Ras.
    • Sequence=BAA76803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL1 Gene


neXtProt entry for RGL1 Gene

Proteomics data for RGL1 Gene at MOPED

Post-translational modifications for RGL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RGL1 Gene

Domains for RGL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NZL6
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RGL1: view

No data available for Gene Families for RGL1 Gene

Function for RGL1 Gene

Molecular function for RGL1 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor

Gene Ontology (GO) - Molecular Function for RGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0008321 Ral guanyl-nucleotide exchange factor activity NAS 10760592
genes like me logo Genes that share ontologies with RGL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RGL1 Gene

Localization for RGL1 Gene

Subcellular locations from

Jensen Localization Image for RGL1 Gene COMPARTMENTS Subcellular localization image for RGL1 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RGL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGL1 Gene

Pathways for RGL1 Gene

genes like me logo Genes that share pathways with RGL1: view

Gene Ontology (GO) - Biological Process for RGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction NAS 10760592
GO:0043547 positive regulation of GTPase activity NAS 10760592
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with RGL1: view

Compounds for RGL1 Gene

(3) HMDB Compounds for RGL1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP

(1) Novoseek inferred chemical compound relationships for RGL1 Gene

Compound -log(P) Hits PubMed IDs
gdp 58.5 3
genes like me logo Genes that share compounds with RGL1: view

Transcripts for RGL1 Gene

Unigene Clusters for RGL1 Gene

Ral guanine nucleotide dissociation stimulator-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -

Relevant External Links for RGL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGL1 Gene

mRNA expression in normal human tissues for RGL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RGL1 Gene

This gene is overexpressed in Blymphocyte (53.5) and Gallbladder (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGL1 Gene

SOURCE GeneReport for Unigene cluster for RGL1 Gene Hs.497148

mRNA Expression by UniProt/SwissProt for RGL1 Gene

Tissue specificity: Expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis
genes like me logo Genes that share expressions with RGL1: view

Expression partners for RGL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RGL1 Gene

Orthologs for RGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RGL1 35
  • 92.28 (n)
  • 95.89 (a)
RGL1 36
  • 96 (a)
(Canis familiaris)
Mammalia RGL1 35
  • 93.57 (n)
  • 96.39 (a)
RGL1 36
  • 96 (a)
(Mus musculus)
Mammalia Rgl1 35
  • 89.86 (n)
  • 95.13 (a)
Rgl1 16
Rgl1 36
  • 94 (a)
(Pan troglodytes)
Mammalia RGL1 35
  • 97.14 (n)
  • 96.35 (a)
RGL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rgl1 35
  • 89.01 (n)
  • 93.25 (a)
(Monodelphis domestica)
Mammalia RGL1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RGL1 36
  • 82 (a)
(Gallus gallus)
Aves RGL1 35
  • 81.56 (n)
  • 88.47 (a)
RGL1 36
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
-- 36
  • 60 (a)
(Danio rerio)
Actinopterygii rgl1 35
  • 66.53 (n)
  • 68.49 (a)
rgl1 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010782 35
  • 47.22 (n)
  • 40.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rgl 35
  • 48.37 (n)
  • 41.38 (a)
Rgl 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea rgl-1 35
  • 46.52 (n)
  • 38.06 (a)
rgl-1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for RGL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGL1 Gene

Gene Tree for RGL1 (if available)
Gene Tree for RGL1 (if available)

Paralogs for RGL1 Gene

Selected SIMAP similar genes for RGL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGL1: view

Variants for RGL1 Gene

Sequence variations from dbSNP and Humsavar for RGL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4650 -- 183,927,827(+) TTTTC(C/T)TAATC utr-variant-3-prime
rs766721 -- 183,792,176(-) ACAAA(A/C)AAAAA intron-variant
rs1073848 -- 183,729,379(+) tcatc(A/G)ttagg intron-variant
rs1112003 -- 183,759,719(-) CAACA(A/C)GGGCC intron-variant
rs1140534 -- 183,912,228(+) GGGCT(A/C)CATTA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for RGL1 Gene

Variant ID Type Subtype PubMed ID
nsv872582 CNV Loss 21882294
nsv832015 CNV Gain 17160897
nsv825598 CNV Gain 20364138
esv259706 OTHER Complex 20981092
nsv441723 CNV CNV 18776908
nsv832026 CNV Gain+Loss 17160897
esv2720140 CNV Deletion 23290073
nsv525878 CNV Gain 19592680
esv1709028 CNV Insertion 17803354

Relevant External Links for RGL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL1 Gene

Disorders for RGL1 Gene

Relevant External Links for RGL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RGL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RGL1 Gene

Publications for RGL1 Gene

  1. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. (PMID: 10760592) Sood R. … Bonner T.I. (Biochim. Biophys. Acta 2000) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  3. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48
  4. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R. … McGuffin P. (Am J Psychiatry 2010) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for RGL1 Gene

Sources for RGL1 Gene

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