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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGL1 Gene

protein-coding   GIFtS: 57
GCID: GC01P183605

ral guanine nucleotide dissociation stimulator-like 1
 Explore 2 diseases affiliated with
RGL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGL1    

Aliases
for RGL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ral Guanine Nucleotide Dissociation Stimulator-Like 11 2
RGL1 2 3 5
RalGDS-Like 12 3
KIAA09593

External Ids:    HGNC: 302811   Entrez Gene: 231792   Ensembl: ENSG000001433447   OMIM: 6056675   UniProtKB: Q9NZL63   

Export aliases for RGL1 gene to outside databases

Previous GC identifers: GC01P180845 GC01P180336 GC01P181871 GC01P154841


Summaries
for RGL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
Function: Probable guanine nucleotide exchange factor




Genomic Views
for RGL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGL1 gene promoter:
         AhR   AML1a   Cdc5   NF-AT   C/EBPalpha   Arnt   NF-AT4   NF-AT2   NF-AT1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.2

RGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P183605:  view genomic region     (about GC identifiers)

Start:
 183,605,208 bp from pter      End:
 183,897,666 bp from pter
Size:
 292,459 bases      Orientation:
 plus strand

Proteins
for RGL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6 (See protein sequence)
Recommended Name: Ral guanine nucleotide dissociation stimulator-like 1  
Size: 768 amino acids; 86701 Da
Subunit: Interacts with Ras (By similarity)
Sequence caution: Sequence=BAA76803.1; Type=Erroneous initiation;
Secondary accessions: Q5SXQ2 Q5SXQ6 Q9HBY3 Q9HBY4 Q9NZL5 Q9UG43 Q9Y2G6
Alternative splicing: 2 isoforms:  Q9NZL6-1   Q9NZL6-2   

Explore the universe of human proteins at neXtProt for RGL1: NX_Q9NZL6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZL6

    • RGL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055964.3  
    ENSEMBL proteins: 
     ENSP00000356501   ENSP00000354097   ENSP00000303192   ENSP00000438662   ENSP00000437355  
    Reactome Protein details: Q9NZL6
    Human Recombinant Protein Products: 
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    Novus Biologicals RGL1 Proteins
    Novus Biologicals RGL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RGL1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--


    RGL1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RGL1

    Protein Domains /
    Families
    for RGL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGL1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc
     IPR019804 Ras_G-nucl-exch_fac_CS

    Graphical View of Domain Structure for InterPro Entry Q9NZL6

    ProtoNet protein and cluster: Q9NZL6

    2 Blocks protein families:
    IPB000159 RA domain
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    Function
    for RGL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
    Function: Probable guanine nucleotide exchange factor

    miRNA
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    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate RGL1 (see all 75):
    hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-4305 hsa-miR-30d hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: RGL1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGL1 (see all 7)
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for RGL1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0008321Ral guanyl-nucleotide exchange factor activity NAS10760592


    RGL1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RGL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3G-protein signaling N-RAS regulation pathway
    		G-protein signaling N-RAS regulation pathway1.00
    		G-protein signaling_N-RAS regulation pathway0.83
    4G-protein signaling K-RAS regulation pathway
    		G-protein signaling K-RAS regulation pathway1.00
    		G-protein signaling_K-RAS regulation pathway0.96
    5Cytoskeleton remodeling_RalB regulation pathway
    		Cytoskeleton remodeling RalA regulation pathway0.23
    		Cytoskeleton remodeling_RalA regulation pathway0.23

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for RGL1
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway


    3 GeneGo (Thomson Reuters) Pathways for RGL1
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway

    5/6        Reactome Pathways for RGL1 (see all 6)
        Expression of RGL1
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    PPARA Activates Gene Expression
    Fatty acid, triacylglycerol, and ketone body metabolism



    RGL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for RGL1 (Q9NZL63 ENSP000003031924) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=9 STRING: ENSP00000309845
    RIT2Q995783, ENSP000003218054I2D: score=1 STRING: ENSP00000321805
    RIT1Q929633, ENSP000003573064I2D: score=3 STRING: ENSP00000357306
    CARM1ENSP000003256904STRING: ENSP00000325690
    CHD9ENSP000003815224STRING: ENSP00000381522
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction NAS10760592
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0051056regulation of small GTPase mediated signal transduction IEA--


    RGL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RGL1

    3 HMDB Compounds for RGL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    1 Novoseek chemical compound relationship for RGL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 58.5 3 9891982 (1), 11856330 (1), 10760592 (1)

    Search CenterWatch for drugs/clinical trials and news about RGL1 

    Transcripts
    for RGL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGL1 gene: 
    NM_015149.3  

    Unigene Cluster for RGL1:

    Ral guanine nucleotide dissociation stimulator-like 1
    Hs.497148  [show with all ESTs]
    Unigene Representative Sequence: NM_015149
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367531 ENST00000360851(uc001gqo.3 uc010poi.2) ENST00000304685(uc010pof.1 uc001gqm.3 uc010pog.2 uc010poh.2)
    ENST00000536277 ENST00000539189

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGL1
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate RGL1 (see all 75):
    hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-4305 hsa-miR-30d hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: RGL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGL1 (see all 7)
    OriGene shRNA RFP: RGL1
    OriGene siRNA: RGL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGL1
    Clone
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    GenScript: all cDNA clones in your preferred vector: RGL1 (NM_015149)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGL1

    Additional cDNA sequence: 

    AB023176.1 AF186779.1 AF186780.1 AK295179.1 AK295611.1 AK304293.1 AK309237.1 AK311701.1 
    AK311716.1 AK316526.1 AL080117.1 BC039250.1 BC136591.1 BX537416.1 

    14 DOTS entries:

    DT.100752130  DT.100645770  DT.95364389  DT.100050607  DT.121440051  DT.121439979  DT.75100513  DT.91865357 
    DT.121440012  DT.121440068  DT.307648  DT.100855250  DT.121440053  DT.97860336 

    24/131 AceView cDNA sequences (see all 131):

    BI835172 BU838668 BX094860 AA149822 AA485825 BE763781 BP349555 CA407199 
    BF445808 Z43856 AI826737 AA341627 AA703533 AA926916 AB023176 CB215399 
    AI473617 AA152068 AA377178 BU735099 CD671776 BQ008743 BM979901 AI278162 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RGL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:              -                 -                                                                                                         
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for RGL1

    Expression
    for RGL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTGCCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RGL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest

    See RGL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGL1

    SOURCE GeneReport for Unigene cluster: Hs.497148

    UniProtKB/Swiss-Prot: RGL1_HUMAN, Q9NZL6
    Tissue specificity: Expressed in a wide variety of tissues with strong expression being seen in the heart, brain,
    kidney, spleen and testis

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGL1

    Orthologs
    for RGL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RGL1 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RGL11 ral guanine nucleotide dissociation stimulator-like more 81.56(n)
    88.47(a)    		   424446  NM_001031271.1  NP_001026442.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 73(a)
    68(a)
    (see all 3)    		 possible ortholog
    1 ↔ 1
    (see all 3)    		 GL343203.1(3888290-3923940)
    GL344486.1(4270-11795)
    zebrafish
    (Danio rerio)    		 Actinopterygii rgl11 ral guanine nucleotide dissociation stimulator-like more 66.76(n)
    68.76(a)    		   402933  NM_205637.1  NP_991200.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rgl1 Ral guanine nucleotide exchange factor 47.9(n)
    41.67(a)    		   44115  NM_079958.2  NP_524697.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rgl-11 Protein RGL-1 46.72(n)
    39.22(a)    		   180611  NM_076149.3  NP_508550.1 


    ENSEMBL Gene Tree for RGL1 (if available)
    TreeFam Gene Tree for RGL1 (if available) 

    Paralogs
    for RGL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGL1 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  RASGRF22  SOS12  RGL32  
    RALGPS12  RALGDS2  RGL42  
    10 SIMAP similar genes for RGL1 using alignment to 3 protein entries:     RGL1_HUMAN (see all proteins):
    DKFZp686C2469    HKE1.5    FLJ00371    RALGDS    RGL4    DKFZp781H1715
    FLJ00185    FLJ00153    RGL3    RGL2

    RGL1 for paralogs           About GeneDecksing



    Genomic Variants
    for RGL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4858 NCBI SNPs in RGL1 are shown (see all 4858)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1930901721,2
    		C,unknown183896812(+) GCCATA/G/TTGTGG 2 -- ut310--------
    rs340147421,2
    		C--155018522(+) TACTC-/TTTATCC 1 -- int12Minor allele frequency- TT:0.25NA 4
    rs1406528051,2
    		--183607107(+) TAAAGG/TTGATT 1 -- int10--------
    rs1447244531,2
    		--183607159(+) AAAATC/TGAACA 1 -- int10--------
    rs1932131751,2
    		--183607183(+) TGACAA/GCAAAT 1 -- int10--------
    rs747209941,2
    		C,F,--183607214(+) TAATAT/CATCTC 1 -- int13Minor allele frequency- C:0.09WA NA EA 358
    rs1855128271,2
    		--183607302(+) TCCCAG/TAGTAG 1 -- int10--------
    rs1163116801,2
    		C,F,--183607348(+) TAATCG/AATTGC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1908180151,2
    		--183607362(+) AGGGTA/GTAATT 1 -- int10--------
    rs67014321,2
    		C,F,A,H,--183607422(+) ATTAAC/TTGCCA 1 -- int110Minor allele frequency- T:0.09NS EA NA WA 912

    HapMap Linkage Disequilibrium report for RGL1 (183605208 - 183855208 bp, first 250kb of RGL1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RGL1
         2 CNVs: 37644 4265

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    Disorders / Diseases
    for RGL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGL1 for disorders           About GeneDecksing

    OMIM gene information: 605667    OMIM disorders: --

    2 diseases for RGL1:    About MalaCards
    conduct disorder    adhd

    Human Genome Epidemiology (HuGE) Navigator: RGL1 (3 documents)

    Export disorders for RGL1 gene to outside databases

    Publications
    for RGL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGL1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with RGL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. (PubMed id 10760592)1, 2, 3, 9 Sood R....Bonner T.I. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Genome-wide pharmacogenetics of antidepressant respon se in the GENDEP project. (PubMed id 20360315)1 Uher R....McGuffin P. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    7. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1 Anney R.J....Gill M. (2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

    External Searches for RGL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    Genome Databases showing RGL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23179 HGNC: 30281 AceView: RGL1 Ensembl:ENSG00000143344 euGenes: HUgn23179
    ECgene: RGL1 H-InvDB: RGL1

    Other Databases showing RGL1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0959

    Specialized Databases showing RGL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RGL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RGL1 gene:
    Search GeneIP for patents involving RGL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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