Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGCC Gene

Aliases for RGCC Gene

  • Regulator Of Cell Cycle 2 3 5
  • Response Gene To Complement 32 Protein 3 4
  • C13orf15 3 4
  • RGC-32 3 4
  • RGC32 3 4
  • Chromosome 13 Open Reading Frame 15 2
  • Response Gene To Complement 32 2
  • Regulator Of Cell Cycle RGCC 3
  • BA157L14.2 3

External Ids for RGCC Gene

Previous HGNC Symbols for RGCC Gene

  • C13orf15

Previous GeneCards Identifiers for RGCC Gene

  • GC13P042032

Summaries for RGCC Gene

Entrez Gene Summary for RGCC Gene

  • This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGCC Gene

RGCC (Regulator Of Cell Cycle) is a Protein Coding gene. Diseases associated with RGCC include Renal Fibrosis and Retinal Cancer. Among its related pathways are Gene Expression and Direct p53 effectors. GO annotations related to this gene include protein kinase binding and R-SMAD binding.

UniProtKB/Swiss-Prot for RGCC Gene

  • Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

Gene Wiki entry for RGCC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGCC Gene

Genomics for RGCC Gene

Regulatory Elements for RGCC Gene

Enhancers for RGCC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G041644 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20 +191.2 191186 8.9 PKNOX1 FOXA2 ZFP64 ARID4B FEZF1 YY1 TCF12 GATA2 FOS SP5 RGCC VWA8 NAA16 OR7E37P OR7E155P RNU6-57P ENSG00000231530 DGKH GC13M041633 GC13M041702
GH13G041491 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +35.3 35300 2.5 PKNOX1 ESRRA MTA2 BHLHE40 NR2F1 TBX21 EP300 PRDM6 JUND IKZF1 RGCC OR7E155P OR7E37P NAA16 ELF1 LOC105370174 GC13P041458 GC13P041459
GH13G041587 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.9 +132.3 132343 3.7 PKNOX1 FOXA2 FEZF1 RAD21 FOS OVOL3 TSHZ1 ZNF843 SREBF1 MAFF RGCC VWA8 DGKH PIR52393 GC13M041633
GH13G041608 1.2 Ensembl ENCODE dbSUPER 16.9 +152.9 152935 3.5 SOX13 ZSCAN4 MAX SIN3A RFX5 CTBP1 RCOR1 SOX5 BHLHE40 CEBPB RGCC OR7E36P GC13M041633 PIR52393
GH13G041693 1.7 FANTOM5 Ensembl ENCODE 10.6 +238.2 238154 4.1 PKNOX1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 SLC30A9 CBX5 ZNF143 RGCC VWA8 DGKH GC13M041702 GC13M041633
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGCC on UCSC Golden Path with GeneCards custom track

Promoters for RGCC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000061799 1394 3201 ATF1 ZNF48 ZNF143 ZNF548 ZNF202 SP3 ZNF592 SMARCA4 MXD3 KDM1A

Genomic Location for RGCC Gene

Chromosome:
13
Start:
41,457,406 bp from pter
End:
41,470,882 bp from pter
Size:
13,477 bases
Orientation:
Plus strand

Genomic View for RGCC Gene

Genes around RGCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGCC Gene

Proteins for RGCC Gene

  • Protein details for RGCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4X1-RGCC_HUMAN
    Recommended name:
    Regulator of cell cycle RGCC
    Protein Accession:
    Q9H4X1
    Secondary Accessions:
    • Q6NZ48
    • Q9UL69

    Protein attributes for RGCC Gene

    Size:
    137 amino acids
    Molecular mass:
    14559 Da
    Quaternary structure:
    • Interacts with SMAD3 (By similarity). Interacts with CDK1 and PLK1.

    Alternative splice isoforms for RGCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGCC Gene

Post-translational modifications for RGCC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGCC Gene

Domains & Families for RGCC Gene

Protein Domains for RGCC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGCC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RGCC Gene

Function for RGCC Gene

Molecular function for RGCC Gene

UniProtKB/Swiss-Prot Function:
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation.

Gene Ontology (GO) - Molecular Function for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19162005
GO:0019901 protein kinase binding ISS,IEA --
GO:0030295 protein kinase activator activity IDA 11687586
GO:0070412 R-SMAD binding IPI 21307346
genes like me logo Genes that share ontologies with RGCC: view
genes like me logo Genes that share phenotypes with RGCC: view

Animal Models for RGCC Gene

MGI Knock Outs for RGCC:
  • Rgcc tm1(KOMP)Wtsi

Animal Model Products

miRNA for RGCC Gene

miRTarBase miRNAs that target RGCC

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGCC Gene

Localization for RGCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGCC Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGCC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11687586
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 11687586
GO:0005813 centrosome IDA 17146433
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with RGCC: view

Pathways & Interactions for RGCC Gene

genes like me logo Genes that share pathways with RGCC: view

Gene Ontology (GO) - Biological Process for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001100 negative regulation of exit from mitosis IDA 17146433
GO:0001937 negative regulation of endothelial cell proliferation IDA 19652095
GO:0003331 positive regulation of extracellular matrix constituent secretion IDA 19158077
GO:0006956 complement activation IMP 19162005
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with RGCC: view

No data available for SIGNOR curated interactions for RGCC Gene

Drugs & Compounds for RGCC Gene

No Compound Related Data Available

Transcripts for RGCC Gene

mRNA/cDNA for RGCC Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(266) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGCC Gene

Regulator of cell cycle:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGCC Gene

No ASD Table

Relevant External Links for RGCC Gene

GeneLoc Exon Structure for
RGCC
ECgene alternative splicing isoforms for
RGCC

Expression for RGCC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGCC Gene

This gene is overexpressed in Lung (x7.7).

Protein differential expression in normal tissues from HIPED for RGCC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.5) and Platelet (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGCC Gene



NURSA nuclear receptor signaling pathways regulating expression of RGCC Gene:

RGCC

SOURCE GeneReport for Unigene cluster for RGCC Gene:

Hs.507866

mRNA Expression by UniProt/SwissProt for RGCC Gene:

Q9H4X1-RGCC_HUMAN
Tissue specificity: Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues.

Evidence on tissue expression from TISSUES for RGCC Gene

  • Nervous system(4.8)
  • Lung(4.2)
  • Muscle(2.2)
  • Bone marrow(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with RGCC: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGCC Gene

Orthologs for RGCC Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGCC 34 35
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia MGC148992 35
  • 90 (a)
OneToOne
RGCC 34
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Rgcc 34 16 35
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Rgcc 34
  • 88.89 (n)
dog
(Canis familiaris)
Mammalia RGCC 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGCC 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGCC 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H13ORF15 34
  • 80.91 (n)
RGCC 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGCC 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgcc 34
  • 73.57 (n)
Str.17679 34
zebrafish
(Danio rerio)
Actinopterygii rgcc 34 35
  • 70.87 (n)
sbcb658 34
Species where no ortholog for RGCC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGCC Gene

ENSEMBL:
Gene Tree for RGCC (if available)
TreeFam:
Gene Tree for RGCC (if available)

Paralogs for RGCC Gene

No data available for Paralogs for RGCC Gene

Variants for RGCC Gene

Sequence variations from dbSNP and Humsavar for RGCC Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000344857 -- 41,458,632(+) ATCAC(C/G)GGAAA intron-variant
rs1000346220 -- 41,462,496(+) GATAC(A/G)TGTGA intron-variant
rs1000438910 -- 41,469,285(+) TAATA(A/G)TAATA intron-variant
rs1000491224 -- 41,469,132(+) GGCGC(A/G)CACCT intron-variant
rs1000770822 -- 41,467,923(+) GACTT(A/G/T)AAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGCC Gene

Variant ID Type Subtype PubMed ID
dgv1634n100 CNV gain 25217958
esv3580617 CNV loss 25503493
nsv509504 CNV insertion 20534489

Variation tolerance for RGCC Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGCC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGCC Gene

Disorders for RGCC Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGCC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal fibrosis
retinal cancer
  • malignant neoplasm of retina
- elite association - COSMIC cancer census association via MalaCards
Search RGCC in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGCC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGCC
genes like me logo Genes that share disorders with RGCC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGCC Gene

Publications for RGCC Gene

  1. RGC-32 mediates transforming growth factor-beta-induced epithelial- mesenchymal transition in human renal proximal tubular cells. (PMID: 19158077) Huang W.Y. … Chen S.Y. (J. Biol. Chem. 2009) 2 3 4 64
  2. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. (PMID: 17146433) Saigusa K. … Inazawa J. (Oncogene 2007) 2 3 4 64
  3. Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. (PMID: 22163048) Schlick S.N. … West M.J. (PLoS ONE 2011) 3 4 64
  4. Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. (PMID: 19652095) An X. … Li J. (Circulation 2009) 2 3 64
  5. Overexpression of RGC-32 in colon cancer and other tumors. (PMID: 15713436) Fosbrink M. … Rus H. (Exp. Mol. Pathol. 2005) 3 4 64

Products for RGCC Gene

Sources for RGCC Gene

Content
Loading form....