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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGCC Gene

protein-coding   GIFtS: 43
GCID: GC13P042032

Regulator Of Cell Cycle

(Previous name: chromosome 13 open reading frame 15)
(Previous symbol: C13orf15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of Cell Cycle1 2     Chromosome 13 Open Reading Frame 151
C13orf151 2 3     Response Gene To Complement 321
RGC322 3 5     bA157L14.22
Response Gene To Complement 32 Protein2 3     Regulator Of Cell Cycle RGCC2
RGC-322 3     

External Ids:    HGNC: 203691   Entrez Gene: 289842   Ensembl: ENSG000001027607   OMIM: 6100775   UniProtKB: Q9H4X13   

Export aliases for RGCC gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGCC Gene:
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by
sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein
localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with
polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system
proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different
assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle
progression. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGCC Gene: 
RGCC (regulator of cell cycle) is a protein-coding gene. Diseases associated with RGCC include hyper ige syndrome, and hypoxia. GO annotations related to this gene include protein kinase activator activity and protein kinase binding.

UniProtKB/Swiss-Prot: RGCC_HUMAN, Q9H4X1
Function: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the
regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at
the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast
activation

Gene Wiki entry for RGCC (C13orf15) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RGCC
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGCC promoter sequence
   Search SABiosciences Chromatin IP Primers for RGCC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11   Ensembl cytogenetic band:  13q14.11   HGNC cytogenetic band: 13q14.11

RGCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGCC gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P042032:  view genomic region     (about GC identifiers)

Start:
42,031,542 bp from pter      End:
42,045,018 bp from pter
Size:
13,477 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGCC_HUMAN, Q9H4X1 (See protein sequence)
Recommended Name: Regulator of cell cycle RGCC  
Size: 137 amino acids; 14559 Da
Subunit: Interacts with SMAD3 (By similarity). Interacts with CDK1 and PLK1
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome
during prometaphase and metaphase
Secondary accessions: Q6NZ48 Q9UL69
Alternative splicing: 2 isoforms:  Q9H4X1-1   Q9H4X1-2   

Explore the universe of human proteins at neXtProt for RGCC: NX_Q9H4X1

Explore proteomics data for RGCC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H4X1

  • RGCC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGCC Protein Expression
    REFSEQ proteins: NP_054778.2  
    ENSEMBL proteins: 
     ENSP00000368664  

    Human Recombinant Protein Products for RGCC: 
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    Novus Biologicals RGCC Proteins
    Novus Biologicals RGCC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA17146433

    RGCC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9H4X1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGCC_HUMAN, Q9H4X1
    Function: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the
    regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at
    the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast
    activation
    Induction: By Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement
    activation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19162005
    GO:0019901protein kinase binding ISS--
    GO:0030295protein kinase activator activity IDA11687586
    GO:0070412R-SMAD binding IPI--
         
    RGCC for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGCC:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGCC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGCC

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGCC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for RGCC
        Direct p53 effectors


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGCC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for RGCC (Q9H4X13 ENSP000003686644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK1P064933I2D: score=2 
    TP53ENSP000002693054STRING: ENSP00000269305
    SMAD2ENSP000002621604STRING: ENSP00000262160
    SMAD3ENSP000003329734STRING: ENSP00000332973
    --ENSP000003060434STRING: ENSP00000306043
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001100negative regulation of exit from mitosis IDA17146433
    GO:0001937negative regulation of endothelial cell proliferation IDA19652095
    GO:0003331positive regulation of extracellular matrix constituent secretion IDA19158077
    GO:0006956complement activation IMP19162005
    GO:0008285negative regulation of cell proliferation IMP17146433

    RGCC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGCC

    Search CenterWatch for drugs/clinical trials and news about RGCC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGCC gene: 
    NM_014059.2  

    Unigene Cluster for RGCC:

    Regulator of cell cycle
    Hs.507866  [show with all ESTs]
    Unigene Representative Sequence: NM_014059
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379359(uc001uyi.2) ENST00000487837
    miRNA
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    Additional mRNA sequence: 

    AF036549.1 BC038706.1 BC066334.1 

    9 DOTS entries:

    DT.100796302  DT.452902  DT.401907  DT.95275292  DT.97783757  DT.70101933  DT.95156759  DT.40244987 
    DT.92434031 

    24/266 AceView cDNA sequences (see all 266):

    BE045692 AI801978 CA308908 AI703132 BQ773679 BE220644 AI784080 CB306686 
    AI218362 CD369472 BE466707 AI096342 BM978289 BM127998 BU784343 AL702539 
    BE671065 AI366815 BE219504 AI804406 AW664030 BF591626 BI518875 BE503145 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGCC expression in normal human tissues (normalized intensities)      RGCC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATATTGT
    RGCC Expression
    About this image


    RGCC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 13 entries
             Adult Endothelial Cells Blood Brain Barrier
             PureStem endothelial progenitor 30-SM2-1
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Adult Endothelial Cells Blood Brain Barrier
             Human Cerebellar Astrocytes   
             brain/forebrain/telencephalon   
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             PureStem endothelial progenitor 30-MV2-12

    See RGCC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGCC

    SOURCE GeneReport for Unigene cluster: Hs.507866

    UniProtKB/Swiss-Prot: RGCC_HUMAN, Q9H4X1
    Tissue specificity: Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal
    muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial
    cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RGCC gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgcc1 , 5 RIKEN cDNA 1190002H23 gene5
    regulator of cell cycle1
    88.32(n)1
    86.86(a)1
      14 (42.59 cM)5
    662141  NM_025427.21  NP_079703.21 
     792887565 
    chicken
    (Gallus gallus)
    Aves C1H13orf151 chromosome 1 open reading frame, human C13orf15 74.94(n)
    69.34(a)
      418833  XM_417029.3  XP_417029.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGCC6
    --
    --
    74(a)
    43(a)
    1 ↔ 1
    possible ortholog
    3(70555341-70569559)
    GL343577.1(223075-233025)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA981373.12   -- 75.22(n)    CA981373.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb6582 sbcb658 79.77(n)   373146  CK354467.1 


    ENSEMBL Gene Tree for RGCC (if available)
    TreeFam Gene Tree for RGCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/330 SNPs in RGCC are shown (see all 330)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1181015821,2
    F--42029606(+) AATATC/AATCCT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs2006895541,2
    --42029655(+) GTACA-/CCCCCC 1 -- us2k10--------
    rs1507440921,2
    --42029662(+) CCCCTA/GTGATA 1 -- us2k10--------
    rs3750517441,2
    C--42029690(+) CTGTCA/C/GCCTGA 1 -- us2k10--------
    rs1921567321,2
    --42029766(+) ACAACA/GGGAAT 1 -- us2k10--------
    rs79949501,2
    C,F,A,H--42029826(+) GAAACA/GATCAA 1 -- us2k110Minor allele frequency- G:0.02NS EA NA WA 1110
    rs740524341,2
    C,F--42029980(+) TCCCAG/ACGGAA 1 -- us2k12Minor allele frequency- A:0.06WA 120
    rs1161788951,2
    C,F--42029997(+) AAACTC/GTTCCT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs606656481,2
    C,F--42029998(+) AACTCT/CTCCTT 1 -- us2k12Minor allele frequency- C:0.02WA NA 238
    rs766215881,2
    --42030014(+) ATCCGC/TTGTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGCC (42031542 - 42045018 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RGCC: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RGCC
    DNA2.0 Custom Variant and Variant Library Synthesis for RGCC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610077    OMIM disorders: --

    8 diseases for RGCC:    About MalaCards
    hyper ige syndrome    hypoxia    ovarian cancer    endotheliitis
    colon cancer    lung cancer    multiple sclerosis    prostatitis


    RGCC for disorders           About GeneDecksing


    Export disorders for RGCC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGCC gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with RGCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. (PubMed id 19158077)1, 2, 3 Huang W.Y....Chen S.Y. (2009)
    2. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. (PubMed id 17146433)1, 2, 3 Saigusa K....Inazawa J. (2007)
    3. Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. (PubMed id 22163048)1, 2 Schlick S.N.... West M.J. (2011)
    4. Response gene to complement 32, a novel hypoxia-regul ated angiogenic inhibitor. (PubMed id 19652095)1, 3 An X....Li J. (2009)
    5. Overexpression of RGC-32 in colon cancer and other tumors. (PubMed id 15713436)1, 2 Fosbrink M....Rus H. (2005)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase. (PubMed id 11687586)1, 2 Badea T.... Rus H. (2002)
    9. Dual role of Response gene to complement-32 in multipl e sclerosis. (PubMed id 23000427)1 Tegla C.A....Rus H. (2013)
    10. Response gene to complement 32 interacts with Smad3 t o promote epithelial-mesenchymal transition of human renal tubular cells. (PubMed id 21307346)1 Guo X....Chen S.Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28984 HGNC: 20369 AceView: RGC32 Ensembl:ENSG00000102760 euGenes: HUgn28984
    ECgene: RGCC H-InvDB: RGCC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGCC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGCC gene:
    Search GeneIP for patents involving RGCC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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