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Aliases for RGCC Gene

Aliases for RGCC Gene

  • Regulator Of Cell Cycle 2 3
  • RGC32 3 4 6
  • Response Gene To Complement 32 Protein 3 4
  • C13orf15 3 4
  • RGC-32 3 4
  • Chromosome 13 Open Reading Frame 15 2
  • Response Gene To Complement 32 2
  • Regulator Of Cell Cycle RGCC 3
  • BA157L14.2 3

External Ids for RGCC Gene

Previous HGNC Symbols for RGCC Gene

  • C13orf15

Previous GeneCards Identifiers for RGCC Gene

  • GC13P042032

Summaries for RGCC Gene

Entrez Gene Summary for RGCC Gene

  • This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGCC Gene

RGCC (Regulator Of Cell Cycle) is a Protein Coding gene. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include protein kinase binding and protein kinase activator activity.

UniProtKB/Swiss-Prot for RGCC Gene

  • Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

Gene Wiki entry for RGCC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGCC Gene

Genomics for RGCC Gene

Genomic Location for RGCC Gene

Start:
41,457,406 bp from pter
End:
41,470,882 bp from pter
Size:
13,477 bases
Orientation:
Plus strand

Genomic View for RGCC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGCC Gene

No data available for Regulatory Elements for RGCC Gene

Proteins for RGCC Gene

  • Protein details for RGCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4X1-RGCC_HUMAN
    Recommended name:
    Regulator of cell cycle RGCC
    Protein Accession:
    Q9H4X1
    Secondary Accessions:
    • Q6NZ48
    • Q9UL69

    Protein attributes for RGCC Gene

    Size:
    137 amino acids
    Molecular mass:
    14559 Da
    Quaternary structure:
    • Interacts with SMAD3 (By similarity). Interacts with CDK1 and PLK1.

    Alternative splice isoforms for RGCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGCC Gene

Proteomics data for RGCC Gene at MOPED

Post-translational modifications for RGCC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGCC Gene

Domains for RGCC Gene

Protein Domains for RGCC Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGCC: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RGCC Gene

Function for RGCC Gene

Molecular function for RGCC Gene

UniProtKB/Swiss-Prot Function: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.
UniProtKB/Swiss-Prot Induction: By Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation.

Gene Ontology (GO) - Molecular Function for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19162005
GO:0019901 protein kinase binding ISS --
GO:0030295 protein kinase activator activity IDA 11687586
GO:0070412 R-SMAD binding IPI 21307346
genes like me logo Genes that share ontologies with RGCC: view

Phenotypes for RGCC Gene

genes like me logo Genes that share phenotypes with RGCC: view

Animal Models for RGCC Gene

MGI Knock Outs for RGCC:
  • Rgcc tm1(KOMP)Wtsi

miRNA for RGCC Gene

miRTarBase miRNAs that target RGCC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RGCC Gene

Localization for RGCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGCC Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.

Gene Ontology (GO) - Cellular Components for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11687586
GO:0005737 cytoplasm IDA 11687586
GO:0005813 centrosome IDA 17146433
genes like me logo Genes that share ontologies with RGCC: view

No data available for Subcellular locations from COMPARTMENTS for RGCC Gene

Pathways for RGCC Gene

SuperPathways for RGCC Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with RGCC: view

Pathways by source for RGCC Gene

1 BioSystems pathway for RGCC Gene

Gene Ontology (GO) - Biological Process for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001100 negative regulation of exit from mitosis IDA 17146433
GO:0001937 negative regulation of endothelial cell proliferation IDA 19652095
GO:0003331 positive regulation of extracellular matrix constituent secretion IDA 19158077
GO:0006956 complement activation IMP 19162005
GO:0008285 negative regulation of cell proliferation IMP 17146433
genes like me logo Genes that share ontologies with RGCC: view

Transcripts for RGCC Gene

mRNA/cDNA for RGCC Gene

(266) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGCC Gene

Regulator of cell cycle:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGCC Gene

No ASD Table

Relevant External Links for RGCC Gene

GeneLoc Exon Structure for
RGCC
ECgene alternative splicing isoforms for
RGCC

Expression for RGCC Gene

mRNA expression in normal human tissues for RGCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGCC Gene

This gene is overexpressed in Lung (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGCC Gene

SOURCE GeneReport for Unigene cluster for RGCC Gene Hs.507866

mRNA Expression by UniProt/SwissProt for RGCC Gene

Q9H4X1-RGCC_HUMAN
Tissue specificity: Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues.
genes like me logo Genes that share expressions with RGCC: view

Orthologs for RGCC Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGCC 35
  • 99.4 (n)
  • 100 (a)
RGCC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC148992 36
  • 90 (a)
OneToOne
RGCC 35
  • 89.79 (n)
  • 89.19 (a)
dog
(Canis familiaris)
Mammalia RGCC 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgcc 35
  • 88.89 (n)
  • 88.29 (a)
Rgcc 16
Rgcc 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGCC 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGCC 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgcc 35
  • 88.89 (n)
  • 91.89 (a)
chicken
(Gallus gallus)
Aves C1H13ORF15 35
  • 80.91 (n)
  • 78.18 (a)
RGCC 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGCC 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgcc 35
  • 73.57 (n)
  • 76.58 (a)
Str.17679 35
zebrafish
(Danio rerio)
Actinopterygii rgcc 35
  • 70.87 (n)
  • 72.07 (a)
rgcc 36
  • 65 (a)
OneToOne
sbcb658 35
Species with no ortholog for RGCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGCC Gene

ENSEMBL:
Gene Tree for RGCC (if available)
TreeFam:
Gene Tree for RGCC (if available)

Paralogs for RGCC Gene

No data available for Paralogs for RGCC Gene

Variants for RGCC Gene

Sequence variations from dbSNP and Humsavar for RGCC Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs7136 -- 41,458,436(-) CTGAC(A/G)CTGGC synonymous-codon, reference
rs396963 -- 41,470,372(+) AGCCC(A/G)GCATT intron-variant
rs872357 -- 41,464,502(+) TTCCC(A/G)AGTAA intron-variant
rs872718 -- 41,458,646(-) GCCCT(C/T)CAGCG intron-variant
rs874417 -- 41,464,568(+) TGTCC(C/T)GTGGT intron-variant

Relevant External Links for RGCC Gene

HapMap Linkage Disequilibrium report
RGCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RGCC Gene

Disorders for RGCC Gene

No disorders were found for RGCC Gene.

No data available for UniProtKB/Swiss-Prot for RGCC Gene

Publications for RGCC Gene

  1. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. (PMID: 17146433) Saigusa K. … Inazawa J. (Oncogene 2007) 2 3 4
  2. RGC-32 mediates transforming growth factor-beta-induced epithelial- mesenchymal transition in human renal proximal tubular cells. (PMID: 19158077) Huang W.Y. … Chen S.Y. (J. Biol. Chem. 2009) 2 3 4
  3. Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. (PMID: 19652095) An X. … Li J. (Circulation 2009) 2 3
  4. RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase. (PMID: 11687586) Badea T. … Rus H. (J. Biol. Chem. 2002) 3 4
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4

Products for RGCC Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RGCC
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RGCC
    • Block miRNA regulation of RGCC using miScript Target Protectors

    Sources for RGCC Gene

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