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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGCC Gene

protein-coding   GIFtS: 46
GCID: GC13P042032

regulator of cell cycle

(Previous name: chromosome 13 open reading frame 15 )
(Previous symbol: C13orf15)
 Explore 8 diseases affiliated with
RGCC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGCC    

Aliases
for RGCC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of Cell Cycle1 2     BA157L14.21
RGC321 2 3 5     Response Gene To Complement 32 Protein2 3
C13orf151 2 3     Chromosome 13 Open Reading Frame 151
RGC-321 2 3     Regulator Of Cell Cycle RGCC2

External Ids:    HGNC: 203691   Entrez Gene: 289842   Ensembl: ENSG000001027607   OMIM: 6100775   UniProtKB: Q9H4X13   

Export aliases for RGCC gene to outside databases


Summaries
for RGCC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RGCC:
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic
levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the
cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1.
The protein also translocates to the nucleus in response to treatment with complement system proteins, and can
associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types,
overexpression of this protein has been shown to activate or suppress cell cycle progression. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: RGCC_HUMAN, Q9H4X1
Function: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the
regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the
G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation

Gene Wiki entry for RGCC (C13orf15)


Genomic Views
for RGCC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RGCC
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGCC promoter sequence
   Search SABiosciences Chromatin IP Primers for RGCC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11   Ensembl cytogenetic band:  13q14.11   HGNC cytogenetic band: 13q14.11

RGCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGCC gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P042032:  view genomic region     (about GC identifiers)

Start:
 42,031,542 bp from pter      End:
 42,045,018 bp from pter
Size:
 13,477 bases      Orientation:
 plus strand

Proteins
for RGCC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGCC_HUMAN, Q9H4X1 (See protein sequence)
Recommended Name: Regulator of cell cycle RGCC  
Size: 137 amino acids; 14559 Da
Subunit: Interacts with SMAD3 (By similarity). Interacts with CDK1 and PLK1
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic in unstimulated cells.
Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase
Secondary accessions: Q6NZ48 Q9UL69
Alternative splicing: 2 isoforms:  Q9H4X1-1   Q9H4X1-2   

Explore the universe of human proteins at neXtProt for RGCC: NX_Q9H4X1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H4X1

    • RGCC Protein expression data from MOPED and PaxDb:    About this image 
    RGCC Protein Expression
    REFSEQ proteins: NP_054778.2  
    ENSEMBL proteins: 
     ENSP00000368664  

    Human Recombinant Protein Products for RGCC: 
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    Novus Biologicals RGCC Proteins
    Novus Biologicals RGCC Lysate
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    Uscn Proteins for RGCC

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA17146433
    GO:0005815microtubule organizing center ----

    RGCC for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RGCC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9H4X1


    Function
    for RGCC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGCC_HUMAN, Q9H4X1
    Function: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the
    regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the
    G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation
    Induction: By Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19162005
    GO:0019901protein kinase binding ISS--
    GO:0030295protein kinase activator activity IDA11687586
    GO:0070412R-SMAD binding IPI--
         
    RGCC for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGCC:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RGCC 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: RGCC 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGCC (see all 4)
    OriGene shRNA RFP: RGCC
    OriGene siRNA: RGCC
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for RGCC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Direct p53 effectors
    		Direct p53 effectors1.00


    1 BioSystems Pathway for RGCC 
        Direct p53 effectors


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGCC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for RGCC (Q9H4X13 ENSP000003686644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK1P064933I2D: score=2 
    TP53ENSP000002693054STRING: ENSP00000269305
    SMAD2ENSP000002621604STRING: ENSP00000262160
    SMAD3ENSP000003329734STRING: ENSP00000332973
    --ENSP000003060434STRING: ENSP00000306043
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity ----
    GO:0001100negative regulation of exit from mitosis IDA17146433
    GO:0001937negative regulation of endothelial cell proliferation IDA19652095
    GO:0003331positive regulation of extracellular matrix constituent secretion IDA19158077
    GO:0006956complement activation IMP19162005

    RGCC for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGCC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGCC
    Search CenterWatch for drugs/clinical trials and news about RGCC 

    Transcripts
    for RGCC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGCC gene: 
    NM_014059.2  

    Unigene Cluster for RGCC:

    Regulator of cell cycle
    Hs.507866  [show with all ESTs]
    Unigene Representative Sequence: NM_014059
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379359(uc001uyi.2) ENST00000487837

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: RGCC 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF036549.1 BC038706.1 BC066334.1 

    9 DOTS entries:

    DT.100796302  DT.452902  DT.401907  DT.95275292  DT.97783757  DT.70101933  DT.95156759  DT.40244987 
    DT.92434031 

    24/266 AceView cDNA sequences (see all 266):

    AA487490 AI336289 AI804406 AI096342 BQ773679 CB529120 BF433670 CA307700 
    AA487704 BE671065 AI377494 AI473229 BE858799 AA403249 BE503145 AW770700 
    AI459224 AW664030 CA306293 AI298484 BI524415 AI366815 BE220644 BM978289 

    GeneLoc Exon Structure


    Expression
    for RGCC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGCC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAATATTGT
    RGCC Expression
    About this image

    RGCC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    LimbAutopodLimb
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14) 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See RGCC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGCC

    SOURCE GeneReport for Unigene cluster: Hs.507866

    UniProtKB/Swiss-Prot: RGCC_HUMAN, Q9H4X1
    Tissue specificity: Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle,
    kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells.
    Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues

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    In Situ
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    Orthologs
    for RGCC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RGCC gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rgcc1 , 5 RIKEN cDNA 1190002H23 gene5
    regulator of cell cycle1    		 88.32(n)1
    86.86(a)1    		   14 (42.59 cM)5
    662141  NM_025427.21  NP_079703.21 
     792887565 
    chicken
    (Gallus gallus)    		 Aves C1H13orf151 chromosome 1 open reading frame, human C13orf15 74.94(n)
    69.34(a)    		   418833  XM_417029.3  XP_417029.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C13orf156
    		 --
    		 74(a)
    		 1 ↔ 1
    		 3(70555341-70569559)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA981373.12   -- 75.22(n)    CA981373.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb6582 sbcb658 79.77(n)   373146  CK354467.1 


    ENSEMBL Gene Tree for RGCC (if available)
    TreeFam Gene Tree for RGCC (if available) 

    Paralogs
    for RGCC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RGCC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/262 NCBI SNPs in RGCC are shown (see all 262)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs95328311,2
    		--22843004(+) taataA/Gtaata 1 -- int10--------
    rs1181015821,2
    		F--42029606(+) AATATC/AATCCT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs2006895541,2
    		--42029655(+) GTACA-/CCCCCC 1 -- us2k10--------
    rs1507440921,2
    		--42029662(+) CCCCTA/GTGATA 1 -- us2k10--------
    rs1921567321,2
    		--42029766(+) ACAACA/GGGAAT 1 -- us2k10--------
    rs79949501,2
    		C,F,A,H--42029826(+) GAAACA/GATCAA 1 -- us2k110Minor allele frequency- G:0.02NS EA NA WA 1110
    rs740524341,2
    		C--42029980(+) TCCCAG/ACGGAA 1 -- us2k12Minor allele frequency- A:0.06WA 120
    rs1161788951,2
    		--42029997(+) AAACTC/GTTCCT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs606656481,2
    		F--42029998(+) AACTCT/CTCCTT 1 -- us2k12Minor allele frequency- C:0.02WA NA 238
    rs766215881,2
    		--42030014(+) ATCCGC/TTGTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGCC (42031542 - 42045018 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RGCC: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGCC
    DNA2.0 Custom Variant and Variant Library Synthesis for RGCC

    Disorders / Diseases
    for RGCC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGCC for disorders           About GeneDecksing

    OMIM gene information: 610077    OMIM disorders: --

    8 diseases for RGCC:    About MalaCards
    hyper-ige syndrome    epithelial ovarian cancer    ovarian cancer    colon cancer
    lung cancer    hypoxia    fibrosis    prostatitis


    Export disorders for RGCC gene to outside databases

    Publications
    for RGCC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGCC gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with RGCC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. (PubMed id 19158077)1, 2, 3 Huang W.Y....Chen S.Y. (2009)
    2. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. (PubMed id 17146433)1, 2, 3 Saigusa K....Inazawa J. (2007)
    3. Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. (PubMed id 22163048)1, 2 Schlick S.N.... West M.J. (2011)
    4. Response gene to complement 32, a novel hypoxia-regul ated angiogenic inhibitor. (PubMed id 19652095)1, 3 An X....Li J. (2009)
    5. Overexpression of RGC-32 in colon cancer and other tumors. (PubMed id 15713436)1, 2 Fosbrink M....Rus H. (2005)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase. (PubMed id 11687586)1, 2 Badea T.... Rus H. (2002)
    9. Response gene to complement 32 interacts with Smad3 t o promote epithelial-mesenchymal transition of human renal tubular cells. (PubMed id 21307346)1 Guo X....Chen S.Y. (2011)
    10. Response gene to complement 32 is essential for fibrob last activation in renal fibrosis. (PubMed id 21990365)1 Li Z....Chen S.Y. (2011)

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