RFXANK Gene
protein-coding GIFtS: 56
GCID: GC19P019303
|
|
regulatory factor X-associated ankyrin-containing protein
| |
Aliases
for RFXANK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulatory Factor X-Associated Ankyrin-Containing Protein1 2 3 | | Regulatory Factor X Subunit B2 3 | | ANKRA11 2 3 | | MGC1386281 | | RFX-B1 2 3 | | RFX-Bdelta42 | | BLS1 2 | | Ankyrin Repeat-Containing Regulatory Factor X-Associated Protein2 | | F14150_11 2 | | DNA-Binding Protein RFXANK2 | | Ankyrin Repeat Family A Protein 12 3 | | RFXB3 |
Export aliases for RFXANK gene to outside databasesPrevious GC identifers: GC19P019797 GC19P019694 GC19P019148 GC19P019164 GC19P018866 |
Summaries
for RFXANK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RFXANK:
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in developmentand control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated proteinand regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters andactivates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHCclass II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression.This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have beenlinked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding differentisoforms have been described for this gene, with only one isoform showing activation activity. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: RFXK_HUMAN, O14593Function: Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class IItransactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. IsoformRFX-B-delta5 is not involved in the positive regulation of MHC class II genes
Gene Wiki entry for RFXANK
|
Genomic Views
for RFXANK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RFXANK gene promoter:
SRF SREBP-1c SRF (504 AA) MIF-1 SREBP-1b c-Ets-1 Roaz AREB6 CREB SREBP-1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RFXANK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFXANK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p12RFXANK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P019303: view genomic region
(about GC identifiers)
Start:
|
19,303,008 bp from pter |
End:
|
19,312,678 bp from pter |
Size:
|
9,671 bases |
Orientation:
|
plus strand |
|
Proteins
for RFXANK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RFXK_HUMAN, O14593 (See
protein sequence)Recommended Name: DNA-binding protein RFXANK Size: 260 amino acids; 28102 Da
Subunit: The RFX heterotetrameric complex consists of 2 molecules of RFX5 and one each of RFXAP and RFX-B/RFXANK; witheach subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with X2BP andCBF/NF-Y. RFX associates with MHC2TA to form an active transcriptional complex
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for RFXANK:3UXG (3D)
3V30 (3D)
Secondary accessions: O95839 Q6FGA8Alternative splicing: 2 isoforms: O14593-1 O14593-2 Explore the universe of human proteins at neXtProt for RFXANK: NX_O14593
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14593
RFXANK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003712.1 NP_604389.1
ENSEMBL proteins: ENSP00000393159 ENSP00000409138 ENSP00000305071 ENSP00000466913 ENSP00000384572 ENSP00000439581 ENSP00000440325 ENSP00000376138 ENSP00000444280 ENSP00000441042 ENSP00000440321 ENSP00000262804
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RFXANK for ontologies About GeneDecksing
RFXANK Antibody Products:
Assay Products for RFXANK: |
Protein
Domains /
Families
for RFXANK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RFXANK for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14593ProtoNet protein and cluster: O14593 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: RFXK_HUMAN, O14593Domain: The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP. The threecentral ANK repeats mediate binding to the PxLPxI/L motif of RFX5Similarity: Contains 5 ANK repeats |
Function
for RFXANK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RFXK_HUMAN, O14593Function: Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class IItransactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. IsoformRFX-B-delta5 is not involved in the positive regulation of MHC class II genes Genatlas biochemistry entry for RFXANK:transactivating DNA binding regulator,28kDa,component of the RFX complex,involved in MHC class II expression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFXANK (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFXANK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RFXANK (NM_003721) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFXANK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFXANK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFXANK |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RFXANK for ontologies About GeneDecksing
|
Pathways & Interactions
for RFXANK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | EGFR1 Signaling Pathway | | | 2 | Signaling events mediated by HDAC Class II | | | 3 | Tuberculosis | | | 4 | Primary immunodeficiency | | | 5 | Allograft rejection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for RFXANK
3 
Kegg Pathways (Kegg details for RFXANK):
RFXANK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFXANK
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/22 Interacting proteins for RFXANK (O145933 ENSP000003050714) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0007265 | Ras protein signal transduction |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- |
RFXANK for ontologies About GeneDecksing
|
Drugs & Compounds
for RFXANK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RFXANK
Search CenterWatch for drugs/clinical trials and news about RFXANK / RFXK
|
Transcripts
for RFXANK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RFXANK gene (2 alternative transcripts): NM_003721.2 NM_134440.1 Unigene Cluster for RFXANK: Regulatory factor X-associated ankyrin-containing protein Hs.296776 [show with all ESTs]Unigene Representative Sequence: BM45579017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000421262 ENST00000456252 ENST00000303088(uc002nls.3 uc002nlv.3 uc021uqt.1)
ENST00000593273 ENST00000407360 ENST00000543652 ENST00000540981 ENST00000543157
ENST00000392324 ENST00000541873 ENST00000545522 ENST00000535017 ENST00000543118
ENST00000540977 ENST00000544923 ENST00000536253 ENST00000353145(uc002nlt.3 uc002nlu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFXANK (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFXANK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RFXANK (NM_003721) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFXANK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFXANK |
Additional cDNA sequence: AF077196.1 AF094760.1 AF105427.1 AF105428.1 BC114558.1 BC114563.1 CR456981.1 CR542199.1 X75690.1 15 DOTS entries: DT.448293 DT.95207353 DT.91761232 DT.100799618 DT.97809250 DT.100736162 DT.121479121 DT.100799613 DT.121479124 DT.91883237 DT.102833957 DT.40116606 DT.95207352 DT.100668792 DT.95207373 24/200 AceView cDNA sequences (see all 200): BQ427991 BM842598 CB990836 BQ065106 AW009837 CF126293 BE549468 BM472689 BI335571 BG741123 BQ054229 AF094760 BE513561 BM789586 BE397018 BM805763 BI906289 CR542199 BU736837 AA359562 BE388797 BM760298 NM_003721 T35325
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RFXANK (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RFXANK
|
Expression
for RFXANK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RFXANK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCTTACCC
About this image
See RFXANK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RFXANK
SOURCE GeneReport for Unigene cluster: Hs.296776
UniProtKB/Swiss-Prot: RFXK_HUMAN, O14593Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for RFXANK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFXANK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RFXANK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFXANK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFXANK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFXANK |
Orthologs
for RFXANK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RFXANK gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RFXANK1 |
regulatory factor X-associated ankyrin-containing protein |
79.03(n)
91.4(a) |
|
426623 NM_001031389.1 NP_001026560.1 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.73502 |
Transcribed sequence with moderate similarity to protein more |
75.05(n) |
|
AL847541.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
rfxank1 |
regulatory factor X-associated ankyrin-containing protein |
64.71(n)
70.05(a) |
|
100170804 NM_001130641.1 NP_001124113.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG58461 |
CG5846 |
50.38(n)
38.07(a) |
|
34326 NM_135489.3 NP_609333.1 |
ENSEMBL Gene Tree for RFXANK (if available)
TreeFam Gene Tree for RFXANK (if available) |
Paralogs
for RFXANK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RFXANK gene
- ANKRA22
9 SIMAP similar genes for RFXANK using alignment to 11 protein entries: RFXK_HUMAN (see all proteins):ZNF554 TMX3 RBMS2 ANKRA2 FEM1B RAI14
DKFZp761E1322 MTPN ANKRD42
RFXANK for paralogs About GeneDecksing
|
Genomic Variants
for RFXANK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RFXANK (19303008 - 19312678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RFXANK: --
Human Gene Mutation Database (HGMD): RFXANK
Locus Specific Mutation Databases (LSDB): RFXANK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFXANK |
|
Disorders
/ Diseases
for RFXANK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RFXANK for disorders About GeneDecksing
OMIM gene information: 603200
OMIM disorders: 209920
UniProtKB/Swiss-Prot: RFXK_HUMAN, O14593
Defects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditaryMHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combinedimmunodeficiency disease with early onset. It is characterized by a profound defect in constitutive andinterferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge,hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral,bacterial and fungal infections
11  diseases for RFXANK: About MalaCardsmhc class ii deficiency, complementation group b bare lymphocyte syndrome mhc class ii deficiency severe combined immunodeficiency
graft versus host disease combined immunodeficiency burkitt's lymphoma immunodeficiency
tuberculosis adenocarcinoma acute graft versus host disease
2 diseases from the University of Copenhagen DISEASES database for RFXANK:Lymphoma Severe combined immunodeficiency 3 Novoseek disease relationships for RFXANK gene About this table
Export disorders for RFXANK gene to outside databases
|
Publications
for RFXANK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RFXANK gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with RFXANK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. (PubMed id 9806546)1, 2, 3, 9 Masternak K.... Reith W. (1998)
- RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. (PubMed id 10072068)1, 2, 3 Nagarajan U.M....Boss J.M. (1999)
- Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B- deficient cells. (PubMed id 10725724)1, 2, 9 Nagarajan U.M....van den Elsen P.J. (2000)
- Sequence-specific recognition of a PxLPxI/L motif by a n ankyrin repeat tumbler lock. (PubMed id 22649097)1, 2 Xu C....Min J. (2012)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Novel mutations in the RFXANK gene: RFX complex containing in-vitro-generated RFXANK mutant binds the promoter without transactivating MHC II. (PubMed id 12618906)1, 9 Wiszniewski W....Lisowska-Grospierre B. (2003)
- RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas. (PubMed id 11836625)1, 9 Dimberg J....Sirsjo A. (2002)
- Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. (PubMed id 15964851)1, 9 Wang A.H....Yang X.J. (2005)
- Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5. (PubMed id 18723135)1, 9 Garvie C.W. and Boss J.M. (2008)
|
External Searches for RFXANK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RFXANK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RFXANK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RFXANK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RFXANK | Pharmacogenomics, SNPs, Pathways | | RFXANKbase | http://bioinf.uta.fi/RFXANKbase/ |
|
| | |
About This Section
| Patent Information for RFXANK gene:
Search GeneIP for patents involving RFXANK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RFXANK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for RFXANK | | OriGene shRNA RFP for RFXANK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFXANK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFXANK | | | OriGene Protein Over-expression Lysate for RFXANK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RFXANK | | OriGene 3'-UTR Clone for RFXANK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFXANK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFXANK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RFXANK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RFXANK | | OriGene Custom Protein Services for RFXANK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RFXANK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFXANK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFXANK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFXANK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFXANK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFXANK |
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| | | | Search Tocris compounds for RFXANK |
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 | | | RFXANK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFXANK |
|  |  |  | | | | ThermoFisher Antibodies for RFXANK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFXANK |
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