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Aliases for RFX8 Gene

Aliases for RFX8 Gene

  • RFX Family Member 8, Lacking RFX DNA Binding Domain 2 3 5
  • RFX Gene Family Member 8, Lacking RFX DNA Binding Domain 2
  • Regulatory Factor X, 8 2
  • Regulatory Factor X 8 4

External Ids for RFX8 Gene

Previous GeneCards Identifiers for RFX8 Gene

  • GC02M102013
  • GC02M095777

Summaries for RFX8 Gene

GeneCards Summary for RFX8 Gene

RFX8 (RFX Family Member 8, Lacking RFX DNA Binding Domain) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is RFX5.

UniProtKB/Swiss-Prot for RFX8 Gene

  • May be a transcription factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFX8 Gene

Genomics for RFX8 Gene

Regulatory Elements for RFX8 Gene

Enhancers for RFX8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RFX8 on UCSC Golden Path with GeneCards custom track

Promoters for RFX8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RFX8 on UCSC Golden Path with GeneCards custom track

Genomic Location for RFX8 Gene

Chromosome:
2
Start:
101,397,344 bp from pter
End:
101,475,096 bp from pter
Size:
77,753 bases
Orientation:
Minus strand

Genomic View for RFX8 Gene

Genes around RFX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFX8 Gene

Proteins for RFX8 Gene

  • Protein details for RFX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZV50-RFX8_HUMAN
    Recommended name:
    DNA-binding protein RFX8
    Protein Accession:
    Q6ZV50
    Secondary Accessions:
    • B4DQ32

    Protein attributes for RFX8 Gene

    Size:
    586 amino acids
    Molecular mass:
    66266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RFX8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFX8 Gene

Proteomics data for RFX8 Gene at MOPED

Post-translational modifications for RFX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFX8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFX8 Gene

Domains & Families for RFX8 Gene

Gene Families for RFX8 Gene

Protein Domains for RFX8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RFX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZV50

UniProtKB/Swiss-Prot:

RFX8_HUMAN :
  • Contains 1 RFX-type winged-helix DNA-binding domain.
  • Belongs to the RFX family.
Domain:
  • Contains 1 RFX-type winged-helix DNA-binding domain.
Family:
  • Belongs to the RFX family.
genes like me logo Genes that share domains with RFX8: view

Function for RFX8 Gene

Molecular function for RFX8 Gene

UniProtKB/Swiss-Prot Function:
May be a transcription factor.

Gene Ontology (GO) - Molecular Function for RFX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with RFX8: view

Phenotypes for RFX8 Gene

GenomeRNAi human phenotypes for RFX8:
genes like me logo Genes that share phenotypes with RFX8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFX8 Gene

Localization for RFX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFX8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFX8 Gene COMPARTMENTS Subcellular localization image for RFX8 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RFX8 Gene

Pathways & Interactions for RFX8 Gene

SuperPathways for RFX8 Gene

No Data Available

Interacting Proteins for RFX8 Gene

Gene Ontology (GO) - Biological Process for RFX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RFX8: view

No data available for Pathways by source and SIGNOR curated interactions for RFX8 Gene

Drugs & Compounds for RFX8 Gene

No Compound Related Data Available

Transcripts for RFX8 Gene

mRNA/cDNA for RFX8 Gene

(11) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFX8 Gene

RFX family member 8, lacking RFX DNA binding domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFX8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2:

Relevant External Links for RFX8 Gene

GeneLoc Exon Structure for
RFX8
ECgene alternative splicing isoforms for
RFX8

Expression for RFX8 Gene

mRNA expression in normal human tissues for RFX8 Gene

Protein differential expression in normal tissues from HIPED for RFX8 Gene

This gene is overexpressed in Nasal epithelium (59.7) and Fetal heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RFX8 Gene



SOURCE GeneReport for Unigene cluster for RFX8 Gene Hs.662488

genes like me logo Genes that share expression patterns with RFX8: view

Protein tissue co-expression partners for RFX8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RFX8 Gene

Orthologs for RFX8 Gene

This gene was present in the common ancestor of animals.

Orthologs for RFX8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RFX8 35
  • 81.15 (n)
  • 74.26 (a)
RFX8 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFX8 35
  • 85.66 (n)
  • 79.26 (a)
RFX8 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rfx8 35
  • 75.64 (n)
  • 69.7 (a)
Rfx8 16
Rfx8 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RFX8 35
  • 93.77 (n)
  • 92.13 (a)
RFX8 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rfx8 35
  • 74.39 (n)
  • 68.61 (a)
oppossum
(Monodelphis domestica)
Mammalia RFX8 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RFX8 35
  • 67.02 (n)
  • 61.13 (a)
RFX8 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea daf-19 36
  • 9 (a)
OneToMany
Species with no ortholog for RFX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RFX8 Gene

ENSEMBL:
Gene Tree for RFX8 (if available)
TreeFam:
Gene Tree for RFX8 (if available)

Paralogs for RFX8 Gene

Paralogs for RFX8 Gene

(3) SIMAP similar genes for RFX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RFX8: view

Variants for RFX8 Gene

Sequence variations from dbSNP and Humsavar for RFX8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1554068 -- 101,410,085(-) TGTCT(A/G)TTTCA intron-variant
rs1554069 -- 101,410,071(-) GGAGA(A/G)CAGCC intron-variant
rs1554070 -- 101,413,086(-) TGCCT(C/T)CCTGT intron-variant
rs908123 -- 101,401,350(+) GCAAT(C/G/T)GGAGA intron-variant
rs908124 -- 101,401,580(+) TCAAA(C/T)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFX8 Gene

Variant ID Type Subtype PubMed ID
esv22386 CNV Gain 19812545
esv2720448 CNV Deletion 23290073
esv2660414 CNV Deletion 23128226
nsv524940 CNV Loss 19592680

Variation tolerance for RFX8 Gene

Gene Damage Index Score: 18.20; 98.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFX8 Gene

Human Gene Mutation Database (HGMD)
RFX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFX8 Gene

Disorders for RFX8 Gene

Relevant External Links for RFX8

Genetic Association Database (GAD)
RFX8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFX8

No disorders were found for RFX8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFX8 Gene

Publications for RFX8 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression. (PMID: 23518928) Liu M. … Weinshilboum R.M. (Mol. Endocrinol. 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for RFX8 Gene

Sources for RFX8 Gene

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