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Aliases for RFX7 Gene

Aliases for RFX7 Gene

  • Regulatory Factor X, 7 2 3
  • Regulatory Factor X Domain-Containing Protein 2 3 4
  • Regulatory Factor X Domain Containing 2 2 3
  • RFXDC2 3 4
  • Regulatory Factor X 7 4

External Ids for RFX7 Gene

Previous HGNC Symbols for RFX7 Gene

  • RFXDC2

Previous GeneCards Identifiers for RFX7 Gene

  • GC15M054170
  • GC15M056379
  • GC15M033206

Summaries for RFX7 Gene

Entrez Gene Summary for RFX7 Gene

  • RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RFX7 Gene

RFX7 (Regulatory Factor X, 7) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is RFX5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFX7 Gene

Genomics for RFX7 Gene

Regulatory Elements for RFX7 Gene

Genomic Location for RFX7 Gene

Chromosome:
15
Start:
56,087,280 bp from pter
End:
56,243,536 bp from pter
Size:
156,257 bases
Orientation:
Minus strand

Genomic View for RFX7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RFX7 Gene

Proteins for RFX7 Gene

  • Protein details for RFX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KHR2-RFX7_HUMAN
    Recommended name:
    DNA-binding protein RFX7
    Protein Accession:
    Q2KHR2
    Secondary Accessions:
    • Q6ZRR1
    • Q6ZTY6
    • Q8N3J0
    • Q9H7A9
    • Q9H956

    Protein attributes for RFX7 Gene

    Size:
    1363 amino acids
    Molecular mass:
    146896 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14381.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14988.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86441.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RFX7 Gene

    Alternative splice isoforms for RFX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFX7 Gene

Proteomics data for RFX7 Gene at MOPED

Post-translational modifications for RFX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFX7 Gene

Domains & Families for RFX7 Gene

Gene Families for RFX7 Gene

Protein Domains for RFX7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RFX7 Gene

Graphical View of Domain Structure for InterPro Entry

Q2KHR2

UniProtKB/Swiss-Prot:

RFX7_HUMAN :
  • Contains 1 RFX-type winged-helix DNA-binding domain.
  • Belongs to the RFX family.
Domain:
  • Contains 1 RFX-type winged-helix DNA-binding domain.
Family:
  • Belongs to the RFX family.
genes like me logo Genes that share domains with RFX7: view

Function for RFX7 Gene

Gene Ontology (GO) - Molecular Function for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with RFX7: view

Phenotypes for RFX7 Gene

genes like me logo Genes that share phenotypes with RFX7: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFX7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RFX7 Gene

Localization for RFX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFX7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFX7 Gene COMPARTMENTS Subcellular localization image for RFX7 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with RFX7: view

Pathways & Interactions for RFX7 Gene

SuperPathways for RFX7 Gene

No Data Available

Interacting Proteins for RFX7 Gene

Selected Interacting proteins: Q2KHR2-RFX7_HUMAN for RFX7 Gene via I2D

Symbol External ID(s) Details
IGHG1
MYC

Gene Ontology (GO) - Biological Process for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with RFX7: view

No data available for Pathways by source and SIGNOR curated interactions for RFX7 Gene

Drugs & Compounds for RFX7 Gene

No Compound Related Data Available

Transcripts for RFX7 Gene

Unigene Clusters for RFX7 Gene

Regulatory factor X, 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFX7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFX7 Gene

No ASD Table

Relevant External Links for RFX7 Gene

GeneLoc Exon Structure for
RFX7
ECgene alternative splicing isoforms for
RFX7

Expression for RFX7 Gene

mRNA expression in normal human tissues for RFX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RFX7 Gene

This gene is overexpressed in Adrenal (52.8) and Kidney (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RFX7 Gene



SOURCE GeneReport for Unigene cluster for RFX7 Gene Hs.745089

genes like me logo Genes that share expression patterns with RFX7: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RFX7 Gene

Orthologs for RFX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RFX7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RFX7 35
  • 92.33 (n)
  • 93.84 (a)
RFX7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFX7 35
  • 94.36 (n)
  • 94.65 (a)
RFX7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rfx7 35
  • 91.7 (n)
  • 92.73 (a)
Rfx7 16
Rfx7 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RFX7 35
  • 99.68 (n)
  • 99.73 (a)
RFX7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rfx7 35
  • 91.29 (n)
  • 93.07 (a)
oppossum
(Monodelphis domestica)
Mammalia RFX7 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFX7 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RFXDC2 35
  • 78.79 (n)
  • 80.33 (a)
RFX7 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RFX7 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rfx7 35
  • 74 (n)
  • 73.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13629 35
zebrafish
(Danio rerio)
Actinopterygii LOC100538179 35
  • 60.82 (n)
  • 60.34 (a)
CU075695.3 36
  • 51 (a)
OneToMany
RFX7 (1 of 2) 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9727 36
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFX1 36
  • 14 (a)
OneToMany
Species with no ortholog for RFX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFX7 Gene

ENSEMBL:
Gene Tree for RFX7 (if available)
TreeFam:
Gene Tree for RFX7 (if available)

Paralogs for RFX7 Gene

Paralogs for RFX7 Gene

(4) SIMAP similar genes for RFX7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RFX7: view

Variants for RFX7 Gene

Sequence variations from dbSNP and Humsavar for RFX7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs748344 -- 56,098,418(+) TCTCC(G/T)TTATA intron-variant
rs748970 -- 56,099,533(-) AGGAA(G/T)GATAA intron-variant
rs764014 -- 56,162,025(-) TCAAA(C/T)AGCAC intron-variant
rs894415 -- 56,188,435(+) gatcc(A/C)agaag intron-variant
rs957071 -- 56,102,453(+) CTTTA(A/G)AATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFX7 Gene

Variant ID Type Subtype PubMed ID
nsv833018 CNV Gain 17160897
esv2676714 CNV Deletion 23128226
esv25623 CNV Loss 19812545
nsv519725 CNV Loss 19592680
nsv833019 CNV Gain 17160897
esv2666678 CNV Deletion 23128226
nsv528965 CNV Loss 19592680
esv2663193 CNV Deletion 23128226
nsv510401 CNV Loss 20534489
nsv827341 CNV Loss 20364138
esv2675469 CNV Deletion 23128226

Variation tolerance for RFX7 Gene

Gene Damage Index Score: 4.07; 60.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFX7 Gene

HapMap Linkage Disequilibrium report
RFX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFX7 Gene

Disorders for RFX7 Gene

Relevant External Links for RFX7

Genetic Association Database (GAD)
RFX7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFX7
genes like me logo Genes that share disorders with RFX7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFX7 Gene

Publications for RFX7 Gene

  1. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 67
  4. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PMID: 23770605) Berndt S.I. … Slager S.L. (Nat. Genet. 2013) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for RFX7 Gene

Sources for RFX7 Gene

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