RFX7 Gene
protein-coding GIFtS: 47
GCID: GC15M056379
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regulatory factor X, 7(Previous name: regulatory factor X domain containing 2 )
(Previous symbol: RFXDC2)
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Aliases
for RFX7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulatory Factor X, 71 2 | | FLJ129941 | | RFXDC21 2 3 5 | | DNA-Binding Protein RFX72 | | Regulatory Factor X Domain Containing 21 2 | | Regulatory Factor X 73 | | Regulatory Factor X Domain-Containing Protein 22 3 | | |
Export aliases for RFX7 gene to outside databasesPrevious GC identifers: GC15M054170 GC15M033206 |
Summaries
for RFX7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RFX7:
RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al.,2008 (PubMed 18673564)).(supplied by OMIM, Mar 2009)
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Genomic Views
for RFX7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RFX7 gene promoter:
AML1a GCNF AP-4 Cdc5 LCR-F1 Tal-1beta E47 FOXL1 GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RFX7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.3 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q21.3RFX7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M056379: view genomic region
(about GC identifiers)
Start:
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56,379,478 bp from pter |
End:
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56,535,483 bp from pter |
Size:
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156,006 bases |
Orientation:
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minus strand |
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Proteins
for RFX7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RFX7_HUMAN, Q2KHR2 (See
protein sequence)Recommended Name: DNA-binding protein RFX7 Size: 1363 amino acids; 146896 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAB14381.1; Type=Erroneous initiation; Sequence=BAB14988.1; Type=Erroneous initiation;Sequence=BAC86441.1; Type=Erroneous initiation;
Secondary accessions: Q6ZRR1 Q6ZTY6 Q8N3J0 Q9H7A9 Q9H956Alternative splicing: 2 isoforms: Q2KHR2-1 Q2KHR2-2 Explore the universe of human proteins at neXtProt for RFX7: NX_Q2KHR2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2KHR2
RFX7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_073752.5
ENSEMBL proteins: ENSP00000453376 ENSP00000453281 ENSP00000453611 ENSP00000387504 ENSP00000313299 ENSP00000397644
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
RFX7 for ontologies About GeneDecksing
RFX7 Antibody Products:
Assay Products for RFX7: |
Protein
Domains /
Families
for RFX7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RFX7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2KHR2ProtoNet protein and cluster: Q2KHR2 1 Blocks protein family: IPB003150 DNA-binding RFX
UniProtKB/Swiss-Prot: RFX7_HUMAN, Q2KHR2Similarity: Belongs to the RFX familySimilarity: Contains 1 RFX-type winged-helix DNA-binding domain |
Function
for RFX7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX7 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RFX7 (NM_022841) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFX7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
RFX7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RFX7:
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Pathways & Interactions
for RFX7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RFX7
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for RFX7 (Q2KHR23 ENSP000003976444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
RFX7 for ontologies About GeneDecksing
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Drugs & Compounds
for RFX7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RFX7
Search CenterWatch for drugs/clinical trials and news about RFX7
|
Transcripts
for RFX7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RFX7 gene: NM_022841.5 Unigene Cluster for RFX7: Regulatory factor X, 7 Hs.282855 [show with all ESTs]Unigene Representative Sequence: CR7494186 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000559847(uc010ugk.1 uc002adn.1) ENST00000559447 ENST00000560792
ENST00000422057 ENST00000317318 ENST00000423270(uc010bfn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX7 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RFX7 (NM_022841) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFX7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX7 |
Additional cDNA sequence: AK023056.1 AK128045.1 AL832584.1 AL833367.1 AL834302.1 BC112936.1 BC143438.1 CR749418.1 7 DOTS entries: DT.406637 DT.91946897 DT.100727639 DT.75156409 DT.91970491 DT.99979598 DT.95109881 24/138 AceView cDNA sequences (see all 138): AI251923 BU634128 AA233556 BF740077 BQ185888 AL833367 AA748527 BQ929567 AA029853 AA828483 AA845327 AL834302 AI926966 AL832584 BX507124 AI393737 BF438795 Z38732 AA830226 AA678626 AI560716 BM824683 AI522288 AK023056
GeneLoc Exon Structure
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Expression
for RFX7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RFX7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCATTTAG
About this image
See RFX7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RFX7
SOURCE GeneReport for Unigene cluster: Hs.282855
SABiosciences Custom PCR Arrays for RFX7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RFX7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX7 |
Orthologs
for RFX7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RFX7 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for RFX7 (if available)
TreeFam Gene Tree for RFX7 (if available) |
Paralogs
for RFX7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RFX7 gene
- RFX52
4 SIMAP similar genes for RFX7 using alignment to 6 protein entries: RFX7_HUMAN (see all proteins):RFX4 RFX5 RFX2 RFX8
RFX7 for paralogs About GeneDecksing
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Genomic Variants
for RFX7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RFX7 (56379478 - 56535483 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RFX7
1 CNV: 49568
1 Indel: 66810 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFX7 |
|
Disorders
/ Diseases
for RFX7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RFX7 for disorders About GeneDecksing
OMIM gene information: 612660
OMIM disorders: --
3  diseases for RFX7: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia leukemia
Export disorders for RFX7 gene to outside databases
|
Publications
for RFX7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RFX7 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RFX7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of novel human tissue-specific RFX transcription factors. (PubMed id 18673564)1, 2 Aftab S.... Chen N. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24 .1 influence chronic lymphocytic leukemia risk. (PubMed id 20062064)1 Crowther-Swanepoel D....Houlston R.S. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
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External Searches for RFX7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RFX7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RFX7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RFX7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RFX7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RFX7 gene:
Search GeneIP for patents involving RFX7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RFX7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RFX7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFX7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for RFX7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RFX7 | | OriGene Custom Protein Services for RFX7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RFX7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFX7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX7 |
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| | | | Search Tocris compounds for RFX7 |
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 | | | RFX7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX7 |
|  |  |  | | | | ThermoFisher Antibodies for RFX7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX7 |
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