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Aliases for RFX7 Gene

Aliases for RFX7 Gene

  • Regulatory Factor X7 2 3 5
  • Regulatory Factor X Domain-Containing Protein 2 3 4
  • Regulatory Factor X Domain Containing 2 2 3
  • Regulatory Factor X, 7 2 3
  • RFXDC2 3 4
  • DNA-Binding Protein RFX7 3
  • Regulatory Factor X 7 4

External Ids for RFX7 Gene

Previous HGNC Symbols for RFX7 Gene

  • RFXDC2

Previous GeneCards Identifiers for RFX7 Gene

  • GC15M054170
  • GC15M056379
  • GC15M033206

Summaries for RFX7 Gene

Entrez Gene Summary for RFX7 Gene

  • RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RFX7 Gene

RFX7 (Regulatory Factor X7) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is RFX5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFX7 Gene

Genomics for RFX7 Gene

Regulatory Elements for RFX7 Gene

Enhancers for RFX7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F056203 0.9 Ensembl 41.9 +38.6 38636 2.6 PKNOX1 PTRF RAD21 DNMT3B KLF13 ZNF654 ZBTB11 JUNB REST HDAC8 RFX7 TEX9 GC15M056171
GH15F056240 1.1 ENCODE 31.9 -0.1 -86 6.2 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 RFX7 TEX9
GH15F056207 0.8 Ensembl ENCODE 22.5 +35.2 35229 2.3 ZNF133 TCF7 STAT3 ETV6 NR2F6 SPI1 ZNF558 RFX7 TEX9 GC15M056171
GH15F056248 0.7 ENCODE 24.6 -5.3 -5259 1.1 CTCF PKNOX1 ZNF654 RNF2 FEZF1 REST RAD21 RFX5 ZNF512 SMC3 RFX7 ENSG00000275417 RNU6-1287P GC15M056276
GH15F056183 0.5 FANTOM5 30.6 +60.3 60322 0.1 ATF3 CEBPB CEBPG RFX7 LOC390586 GC15P056091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RFX7 on UCSC Golden Path with GeneCards custom track

Promoters for RFX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021214 736 4401 CREB3L1 SIN3A SLC30A9 ZNF263 NFYC JUNB SMARCB1 SREBF1 CREB3 ZNF610

Genomic Location for RFX7 Gene

Chromosome:
15
Start:
56,087,280 bp from pter
End:
56,243,536 bp from pter
Size:
156,257 bases
Orientation:
Minus strand

Genomic View for RFX7 Gene

Genes around RFX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFX7 Gene

Proteins for RFX7 Gene

  • Protein details for RFX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KHR2-RFX7_HUMAN
    Recommended name:
    DNA-binding protein RFX7
    Protein Accession:
    Q2KHR2
    Secondary Accessions:
    • Q6ZRR1
    • Q6ZTY6
    • Q8N3J0
    • Q9H7A9
    • Q9H956

    Protein attributes for RFX7 Gene

    Size:
    1363 amino acids
    Molecular mass:
    146896 Da
    Quaternary structure:
    • Interacts (via PxLPxI/L motif) with RFXANK (via ankyrin repeats) (PubMed:25752541). Interacts (via PxLPxI/L motif) with ANKRA2 (via ankyrin repeats) (PubMed:25752541).
    SequenceCaution:
    • Sequence=BAB14381.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14988.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86441.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RFX7 Gene

    Alternative splice isoforms for RFX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFX7 Gene

Post-translational modifications for RFX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFX7 Gene

No data available for DME Specific Peptides for RFX7 Gene

Domains & Families for RFX7 Gene

Gene Families for RFX7 Gene

Protein Domains for RFX7 Gene

Suggested Antigen Peptide Sequences for RFX7 Gene

Graphical View of Domain Structure for InterPro Entry

Q2KHR2

UniProtKB/Swiss-Prot:

RFX7_HUMAN :
  • The PxLPxI/L motif mediates interaction with ankyrin repeats of ANKRA2 and RFXANK.
  • Belongs to the RFX family.
Domain:
  • The PxLPxI/L motif mediates interaction with ankyrin repeats of ANKRA2 and RFXANK.
  • Contains 1 RFX-type winged-helix DNA-binding domain.
Family:
  • Belongs to the RFX family.
genes like me logo Genes that share domains with RFX7: view

Function for RFX7 Gene

Gene Ontology (GO) - Molecular Function for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with RFX7: view
genes like me logo Genes that share phenotypes with RFX7: view

Animal Models for RFX7 Gene

MGI Knock Outs for RFX7:
  • Rfx7 tm2b(EUCOMM)Hmgu

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RFX7 Gene

Localization for RFX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFX7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFX7 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with RFX7: view

Pathways & Interactions for RFX7 Gene

No Data Available

Interacting Proteins for RFX7 Gene

Selected Interacting proteins: Q2KHR2-RFX7_HUMAN for RFX7 Gene via IID

Gene Ontology (GO) - Biological Process for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with RFX7: view

No data available for Pathways by source and SIGNOR curated interactions for RFX7 Gene

Transcripts for RFX7 Gene

Unigene Clusters for RFX7 Gene

Regulatory factor X, 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFX7 Gene

No ASD Table

Relevant External Links for RFX7 Gene

GeneLoc Exon Structure for
RFX7
ECgene alternative splicing isoforms for
RFX7

Expression for RFX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RFX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RFX7 Gene

This gene is overexpressed in Adrenal (52.8) and Kidney (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RFX7 Gene



NURSA nuclear receptor signaling pathways regulating expression of RFX7 Gene:

RFX7

SOURCE GeneReport for Unigene cluster for RFX7 Gene:

Hs.745089
genes like me logo Genes that share expression patterns with RFX7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RFX7 Gene

Orthologs for RFX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RFX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFX7 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia RFX7 34 35
  • 94.36 (n)
cow
(Bos Taurus)
Mammalia RFX7 34 35
  • 92.33 (n)
mouse
(Mus musculus)
Mammalia Rfx7 34 16 35
  • 91.7 (n)
rat
(Rattus norvegicus)
Mammalia Rfx7 34
  • 91.29 (n)
oppossum
(Monodelphis domestica)
Mammalia RFX7 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFX7 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RFXDC2 34
  • 78.79 (n)
RFX7 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RFX7 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rfx7 34
  • 74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13629 34
zebrafish
(Danio rerio)
Actinopterygii LOC100538179 34
  • 60.82 (n)
RFX7 (1 of 2) 35
  • 56 (a)
OneToMany
CU075695.3 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9727 35
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFX1 35
  • 14 (a)
OneToMany
Species where no ortholog for RFX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFX7 Gene

ENSEMBL:
Gene Tree for RFX7 (if available)
TreeFam:
Gene Tree for RFX7 (if available)

Paralogs for RFX7 Gene

Paralogs for RFX7 Gene

(4) SIMAP similar genes for RFX7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RFX7: view

Variants for RFX7 Gene

Sequence variations from dbSNP and Humsavar for RFX7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152289 -- 56,142,378(+) GCCTT(A/T)AAAAA intron-variant
rs10152462 -- 56,140,061(+) ctgct(A/G)tcttt intron-variant
rs10162834 -- 56,157,406(+) GGGAC(C/G)TAACT intron-variant
rs10163161 -- 56,166,432(+) GTTGG(A/G)AGACT intron-variant
rs1031077 -- 56,141,852(+) AGAGT(C/T)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFX7 Gene

Variant ID Type Subtype PubMed ID
nsv951966 CNV deletion 24416366
nsv833019 CNV gain 17160897
nsv833018 CNV gain 17160897
nsv827341 CNV loss 20364138
nsv569547 CNV loss 21841781
nsv528965 CNV loss 19592680
nsv519725 CNV loss 19592680
nsv510401 OTHER sequence alteration 20534489
esv3636579 CNV loss 21293372
esv3636578 CNV loss 21293372
esv3636577 CNV loss 21293372
esv3636575 CNV loss 21293372
esv3569620 CNV gain 25503493
esv2761872 CNV gain 21179565
esv2760380 CNV loss 21179565
esv2676714 CNV deletion 23128226
esv2675469 CNV deletion 23128226
esv2666678 CNV deletion 23128226
esv2663193 CNV deletion 23128226
esv25623 CNV loss 19812545

Variation tolerance for RFX7 Gene

Gene Damage Index Score: 4.07; 60.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFX7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RFX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFX7 Gene

Disorders for RFX7 Gene

Relevant External Links for RFX7

Genetic Association Database (GAD)
RFX7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFX7

No disorders were found for RFX7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFX7 Gene

Publications for RFX7 Gene

  1. Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. (PMID: 25752541) Nie J. … Yang X.J. (Structure 2015) 3 4 64
  2. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PMID: 20062064) Crowther-Swanepoel D. … Houlston R.S. (Nat. Genet. 2010) 3 46 64
  3. Identification and characterization of novel human tissue-specific RFX transcription factors. (PMID: 18673564) Aftab S. … Chen N. (BMC Evol. Biol. 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz C.C. … Taylor C.T. (PLoS Biol. 2016) 3 64

Products for RFX7 Gene

Sources for RFX7 Gene

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