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Aliases for RFX7 Gene

Aliases for RFX7 Gene

  • Regulatory Factor X, 7 2 3
  • RFXDC2 3 4 6
  • Regulatory Factor X Domain-Containing Protein 2 3 4
  • Regulatory Factor X Domain Containing 2 2 3
  • DNA-Binding Protein RFX7 3
  • Regulatory Factor X 7 4

External Ids for RFX7 Gene

Previous HGNC Symbols for RFX7 Gene

  • RFXDC2

Previous GeneCards Identifiers for RFX7 Gene

  • GC15M054170
  • GC15M056379
  • GC15M033206

Summaries for RFX7 Gene

Entrez Gene Summary for RFX7 Gene

  • RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RFX7 Gene

RFX7 (Regulatory Factor X, 7) is a Protein Coding gene. An important paralog of this gene is RFX5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFX7 Gene

Genomics for RFX7 Gene

Regulatory Elements for RFX7 Gene

Genomic Location for RFX7 Gene

Start:
56,087,280 bp from pter
End:
56,243,445 bp from pter
Size:
156,166 bases
Orientation:
Minus strand

Genomic View for RFX7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFX7 Gene

Proteins for RFX7 Gene

  • Protein details for RFX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KHR2-RFX7_HUMAN
    Recommended name:
    DNA-binding protein RFX7
    Protein Accession:
    Q2KHR2
    Secondary Accessions:
    • Q6ZRR1
    • Q6ZTY6
    • Q8N3J0
    • Q9H7A9
    • Q9H956

    Protein attributes for RFX7 Gene

    Size:
    1363 amino acids
    Molecular mass:
    146896 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14381.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14988.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86441.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RFX7 Gene

    Alternative splice isoforms for RFX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFX7 Gene

Proteomics data for RFX7 Gene at MOPED

Post-translational modifications for RFX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFX7 Gene

Domains for RFX7 Gene

Protein Domains for RFX7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RFX7 Gene

Graphical View of Domain Structure for InterPro Entry

Q2KHR2

UniProtKB/Swiss-Prot:

RFX7_HUMAN :
  • Q2KHR2
Domain:
  • Contains 1 RFX-type winged-helix DNA-binding domain.
Family:
  • Belongs to the RFX family.
genes like me logo Genes that share domains with RFX7: view

No data available for Gene Families for RFX7 Gene

Function for RFX7 Gene

Gene Ontology (GO) - Molecular Function for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with RFX7: view

Phenotypes for RFX7 Gene

GenomeRNAi human phenotypes for RFX7:
genes like me logo Genes that share phenotypes with RFX7: view

Animal Model Products

CRISPR Products

miRNA for RFX7 Gene

miRTarBase miRNAs that target RFX7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFX7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RFX7 Gene

Localization for RFX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFX7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFX7 Gene COMPARTMENTS Subcellular localization image for RFX7 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with RFX7: view

Pathways for RFX7 Gene

SuperPathways for RFX7 Gene

No Data Available

Interacting Proteins for RFX7 Gene

Selected Interacting proteins: Q2KHR2-RFX7_HUMAN for RFX7 Gene via I2D

Symbol External ID(s) Details
IGHG1
MYC

Gene Ontology (GO) - Biological Process for RFX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with RFX7: view

No data available for Pathways by source for RFX7 Gene

Transcripts for RFX7 Gene

Unigene Clusters for RFX7 Gene

Regulatory factor X, 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFX7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RFX7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFX7 Gene

No ASD Table

Relevant External Links for RFX7 Gene

GeneLoc Exon Structure for
RFX7
ECgene alternative splicing isoforms for
RFX7

Expression for RFX7 Gene

mRNA expression in normal human tissues for RFX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RFX7 Gene

SOURCE GeneReport for Unigene cluster for RFX7 Gene Hs.745089

genes like me logo Genes that share expressions with RFX7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RFX7 Gene

Orthologs for RFX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RFX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFX7 35
  • 99.68 (n)
  • 99.73 (a)
RFX7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RFX7 35
  • 92.33 (n)
  • 93.84 (a)
RFX7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFX7 35
  • 94.36 (n)
  • 94.65 (a)
RFX7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rfx7 35
  • 91.7 (n)
  • 92.73 (a)
Rfx7 16
Rfx7 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RFX7 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFX7 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rfx7 35
  • 91.29 (n)
  • 93.07 (a)
chicken
(Gallus gallus)
Aves RFX7 36
  • 77 (a)
OneToOne
RFXDC2 35
  • 78.79 (n)
  • 80.33 (a)
lizard
(Anolis carolinensis)
Reptilia RFX7 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13629 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rfx7 35
  • 74 (n)
  • 73.57 (a)
zebrafish
(Danio rerio)
Actinopterygii CU075695.3 36
  • 51 (a)
OneToMany
LOC100538179 35
  • 60.82 (n)
  • 60.34 (a)
RFX7 (1 of 2) 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9727 36
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFX1 36
  • 14 (a)
OneToMany
Species with no ortholog for RFX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFX7 Gene

ENSEMBL:
Gene Tree for RFX7 (if available)
TreeFam:
Gene Tree for RFX7 (if available)

Paralogs for RFX7 Gene

Paralogs for RFX7 Gene

Selected SIMAP similar genes for RFX7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RFX7: view

Variants for RFX7 Gene

Sequence variations from dbSNP and Humsavar for RFX7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs748344 -- 56,098,418(+) TCTCC(G/T)TTATA intron-variant
rs748970 -- 56,099,533(-) AGGAA(G/T)GATAA intron-variant
rs764014 -- 56,162,025(-) TCAAA(C/T)AGCAC intron-variant
rs894415 -- 56,188,435(+) gatcc(A/C)agaag intron-variant
rs957071 -- 56,102,453(+) CTTTA(A/G)AATGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RFX7 Gene

Variant ID Type Subtype PubMed ID
nsv833018 CNV Gain 17160897
esv2676714 CNV Deletion 23128226
esv25623 CNV Loss 19812545
nsv519725 CNV Loss 19592680
nsv833019 CNV Gain 17160897
esv2666678 CNV Deletion 23128226
nsv528965 CNV Loss 19592680
esv2663193 CNV Deletion 23128226
nsv510401 CNV Loss 20534489
nsv827341 CNV Loss 20364138
esv2675469 CNV Deletion 23128226

Relevant External Links for RFX7 Gene

HapMap Linkage Disequilibrium report
RFX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFX7 Gene

Disorders for RFX7 Gene

Relevant External Links for RFX7

Genetic Association Database (GAD)
RFX7
genes like me logo Genes that share disorders with RFX7: view

No data available for UniProtKB/Swiss-Prot for RFX7 Gene

Publications for RFX7 Gene

  1. Identification and characterization of novel human tissue-specific RFX transcription factors. (PMID: 18673564) Aftab S. … Chen N. (BMC Evol. Biol. 2008) 3 4
  2. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PMID: 20062064) Crowther-Swanepoel D. … Houlston R.S. (Nat. Genet. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RFX7 Gene

Sources for RFX7 Gene

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