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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFX6 Gene

protein-coding   GIFtS: 52
GCID: GC06P117199

Regulatory Factor X, 6

(Previous name: regulatory factor X domain containing 1)
(Previous symbol: RFXDC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulatory Factor X, 61 2     MTFS2
RFXDC11 2 3 5     dJ955L16.12
Regulatory Factor X Domain-Containing Protein 12 3     DNA-Binding Protein RFX62
Regulatory Factor X Domain Containing 11     Regulatory Factor X 63

External Ids:    HGNC: 214781   Entrez Gene: 2225462   Ensembl: ENSG000001850027   OMIM: 6126595   UniProtKB: Q8HWS33   

Export aliases for RFX6 gene to outside databases

Previous GC identifers: GC06P117306 GC06P114778


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RFX6 Gene:
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription
factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells
for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It
regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the
expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with
Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and
jejunal atresia, and gall bladder agenesis.(provided by RefSeq, Sep 2010)

GeneCards Summary for RFX6 Gene: 
RFX6 (regulatory factor X, 6) is a protein-coding gene. Diseases associated with RFX6 include jejunal atresia, and annular pancreas. GO annotations related to this gene include protein binding and transcription regulatory region DNA binding. An important paralog of this gene is RFX1.

UniProtKB/Swiss-Prot: RFX6_HUMAN, Q8HWS3
Function: Transcription factor required to direct islet cell differentiation during endocrine pancreas
development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production
of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of
NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby
restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate
choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of
target genes

Gene Wiki entry for RFX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFX6 gene promoter:
         ATF-2   CUTL1   POU3F2   MEF-2A   AREB6   MZF-1   FOXJ2 (long isoform)   FOXJ2   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RFX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.31

RFX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFX6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P117199:  view genomic region     (about GC identifiers)

Start:
117,198,375 bp from pter      End:
117,253,326 bp from pter
Size:
54,952 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RFX6_HUMAN, Q8HWS3 (See protein sequence)
Recommended Name: DNA-binding protein RFX6  
Size: 928 amino acids; 102461 Da
Subunit: Interacts with RFX3 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5T6B3

Explore the universe of human proteins at neXtProt for RFX6: NX_Q8HWS3

Explore proteomics data for RFX6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8HWS3

  • RFX6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RFX6 Protein Expression
    REFSEQ proteins: NP_775831.2  
    ENSEMBL proteins: 
     ENSP00000332208  

    Human Recombinant Protein Products for RFX6: 
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    OriGene Protein Over-expression Lysate for RFX6
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    Novus Biologicals RFX6 Protein
    Novus Biologicals RFX6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFX6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    RFX6 for ontologies           About GeneDecksing



    RFX6 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RFX6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003150 DNA-bd_RFX

    Graphical View of Domain Structure for InterPro Entry Q8HWS3

    ProtoNet protein and cluster: Q8HWS3

    2 Blocks protein domains:
    IPB003150 DNA-binding RFX
    IPB006678 tRNA intron endonuclease


    UniProtKB/Swiss-Prot: RFX6_HUMAN, Q8HWS3
    Similarity: Belongs to the RFX family
    Similarity: Contains 1 RFX-type winged-helix DNA-binding domain


    RFX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFX6_HUMAN, Q8HWS3
    Function: Transcription factor required to direct islet cell differentiation during endocrine pancreas
    development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production
    of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of
    NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby
    restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate
    choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of
    target genes

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI--
    GO:0044212transcription regulatory region DNA binding IDA--
         
    RFX6 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rfx6):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  mortality/aging 

    RFX6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RFX6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RFX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFX6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFX6 

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX6 (see all 17):
    hsa-miR-98 hsa-miR-3671 hsa-miR-30c hsa-let-7d hsa-let-7c hsa-miR-30d hsa-let-7i hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRFX6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RFX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for RFX6 (Q8HWS33 ENSP000003322084) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNKO759093, ENSP000003745294I2D: score=3 STRING: ENSP00000374529
    RFX2P483783, ENSP000003063354I2D: score=3 STRING: ENSP00000306335
    RFX3P483803, ENSP000003714344I2D: score=3 STRING: ENSP00000371434
    SS18L1O751773, ENSP000003330124I2D: score=2 STRING: ENSP00000333012
    DTX2Q86UW93, ENSP000003228854I2D: score=3 STRING: ENSP00000322885
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003309type B pancreatic cell differentiation ISS--
    GO:0003310pancreatic A cell differentiation ISS--
    GO:0003311pancreatic D cell differentiation ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    RFX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RFX6

    Search CenterWatch for drugs/clinical trials and news about RFX6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RFX6 gene: 
    NM_173560.3  

    Unigene Cluster for RFX6:

    Regulatory factor X, 6
    Hs.352276  [show with all ESTs]
    Unigene Representative Sequence: BC039248
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487683 ENST00000332958(uc003pxm.3) ENST00000471966
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFX6
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX6 (see all 17):
    hsa-miR-98 hsa-miR-3671 hsa-miR-30c hsa-let-7d hsa-let-7c hsa-miR-30d hsa-let-7i hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRFX6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RFX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX6
    Clone
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    OriGene clones in human, mouse for RFX6 (see all 8)
    OriGene ORF clones in mouse, rat for RFX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RFX6 (NM_173560)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX6
    Sirion Biotech Customized lentivirus for stable overexpression of RFX6 
                         Customized lentivirus expression plasmids for stable overexpression of RFX6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RFX6
    OriGene qSTAR qPCR primer pairs in human, mouse for RFX6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RFX6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX6

    Additional mRNA sequence: BC039248.1 

    1 DOTS entry:

    DT.40193232 

    19 AceView cDNA sequences:

    BC039248 BM272227 CA842450 NM_173560 BM312870 CB129710 BU079079 BU078799 
    CA842968 AI371188 BM313162 BQ269808 AA319041 BI464579 BG220394 BQ286462 
    BM272437 CA947154 BV192440 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFX6 expression in normal human tissues (normalized intensities)      RFX6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACAGCAG
    RFX6 Expression
    About this image


    RFX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 5 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Islets of Langerhans
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Melanocytes (Integumentary System)
             skin ; melanocytes   

    See RFX6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RFX6

    SOURCE GeneReport for Unigene cluster: Hs.352276

    UniProtKB/Swiss-Prot: RFX6_HUMAN, Q8HWS3
    Tissue specificity: Specifically expressed in pancreas, small intestine and colon

        SABiosciences Custom PCR Arrays for RFX6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RFX6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfx61 , 5 regulatory factor X, 61, 5 85.98(n)1
    87.49(a)1
      10 (25.74 cM)5
    3209951  NM_001159389.11  NP_001152861.11 
     516777565 
    chicken
    (Gallus gallus)
    Aves RFX61 regulatory factor X, 6 75.78(n)
    78.09(a)
      421737  XM_419769.3  XP_419769.3 
    lizard
    (Anolis carolinensis)
    Reptilia RFX66
    Uncharacterized protein
    76(a)
    1 ↔ 1
    1(185814536-185859361)
    zebrafish
    (Danio rerio)
    Actinopterygii rfx61 regulatory factor X, 6 67.75(n)
    70.16(a)
      556925  XM_679861.3  XP_684953.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RFX16
    Major transcriptional repressor of DNA-damage-regu...
    12(a)
    1 → many
    XII(507797-510232)


    ENSEMBL Gene Tree for RFX6 (if available)
    TreeFam Gene Tree for RFX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFX6 gene
    RFX12  RFX32  RFX82  RFX42  RFX22  
    1 SIMAP similar gene for RFX6 using alignment to 1 protein entry:     RFX6_HUMAN:
    RFX4

    RFX6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1079 SNPs in RFX6 are shown (see all 1079)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0629794
    Mitchell-Riley syndrome (MIRIS)4--see VAR_0629792 S P mis40--------
    VAR_0629784
    Mitchell-Riley syndrome (MIRIS)4--see VAR_0629782 R Q mis40--------
    rs592649991,2
    C--114810608(+) TTTTT-/T/    
       TTTTT
    GAGAC
    1 -- int11NA 2
    rs113433561,2
    C--114814056(+) AAGTG-/CCTGCC 1 -- int10--------
    rs1995483031,2
    C--114820413(+) ATGATA/GAGAAG 1 -- int10--------
    rs2008921571,2
    C--114820415(+) GATAAG/TAAGCT 1 -- int10--------
    rs2004814871,2
    --114820417(+) TAAGA-/AGCTGGAT 1 -- int10--------
    rs735634061,2
    C--117196780(+) ACACAC/AACACA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs94816781,2
    C,F,H--117197558(+) CATACG/ATTTGA 1 -- us2k17Minor allele frequency- A:0.03NS EA WA CSA 542
    rs1931000821,2
    C--117197605(+) ATAAAA/TCACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RFX6 (117198375 - 117253326 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RFX6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830784CNV Gain17160897


    Human Gene Mutation Database (HGMD): RFX6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RFX6
    DNA2.0 Custom Variant and Variant Library Synthesis for RFX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612659    OMIM disorders: --

    UniProtKB/Swiss-Prot: RFX6_HUMAN, Q8HWS3
  • Mitchell-Riley syndrome (MIRIS) [MIM:601346]: A disorder characterized by neonatal diabetes, hypoplastic
    or annular pancreas, duodenal and jejunal atresia, and absent gallbladder. There is no dysmorphic features.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for RFX6:    About MalaCards
    jejunal atresia    annular pancreas    duodenitis    lipomatosis
    pancreatitis    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RFX6:
    Intestinal atresia

    RFX6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RFX6
    Human Genome Epidemiology (HuGE) Navigator: RFX6 (2 documents)

    Export disorders for RFX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RFX6 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with RFX6)
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    1. Rfx6 directs islet formation and insulin production in mice and humans. (PubMed id 20148032)1, 2 Smith S.B.... German M.S. (2010)
    2. Genome-wide association study identifies five new sus ceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)1, 4 Takata R....Nakagawa H. (2010)
    3. Identification and characterization of novel human tissue-specific RFX transcription factors. (PubMed id 18673564)1, 2 Aftab S.... Chen N. (2008)
    4. Replication and fine mapping for association of the C2 orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese populati on. (PubMed id 22662242)1 Long Q.Z....Liu X.G. (2012)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Functional analysis of Rfx6 and mutant variants assoc iated with neonatal diabetes. (PubMed id 21215266)1 Pearl E.J....Horb M.E. (2011)
    7. RFX6 is needed for the development and maintenance of the I^-cell phenotype. (PubMed id 21750414)1 Taleb N. and Polychronakos C. (2011)
    8. Clinical characterization of a newly described neonat al diabetes syndrome caused by RFX6 mutations. (PubMed id 21965172)1 Spiegel R....Shalev S.A. (2011)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222546 HGNC: 21478 AceView: RFXDC1 Ensembl:ENSG00000185002 euGenes: HUgn222546
    ECgene: RFX6 H-InvDB: RFX6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFX6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RFX6 gene:
    Search GeneIP for patents involving RFX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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