RFX5 Gene
protein-coding GIFtS: 60
GCID: GC01M151313
|
|
regulatory factor X, 5 (influences HLA class II expression)
| |
Aliases
for RFX5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulatory Factor X, 5 (Influences HLA Class II Expression)1 2 | | Regulatory Factor X 52 3 | | DNA-Binding Protein RFX52 |
Export aliases for RFX5 gene to outside databasesPrevious GC identifers: GC01M149155 GC01M147060 GC01M148088 GC01M148529 GC01M148126 GC01M149579 GC01M122691 |
Summaries
for RFX5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RFX5:
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the barelymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell linesestablished from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to adeficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX bindingactivity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimleet al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highlycharacteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have beenfound but the full-length natures of only two have been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RFX5_HUMAN, P48382Function: Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding betweenRFX and NF-Y. RFX binds the X1 box of MHC-II promoters
Gene Wiki entry for RFX5
|
Genomic Views
for RFX5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RFX5 gene promoter:
CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for RFX5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21RFX5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M151313: view genomic region
(about GC identifiers)
Start:
|
151,313,116 bp from pter |
End:
|
151,319,833 bp from pter |
Size:
|
6,718 bases |
Orientation:
|
minus strand |
|
Proteins
for RFX5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RFX5_HUMAN, P48382 (See
protein sequence)Recommended Name: DNA-binding protein RFX5 Size: 616 amino acids; 65323 Da
Subunit: Homodimer. The RFX heterotetrameric complex consists of 2 molecules of RFX5 and one each of RFXAP andRFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA bindingcomplexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for RFX5:2KW3 (3D)
3V30 (3D)
Secondary accessions: D3DV19 Q5VWC3Explore the universe of human proteins at neXtProt for RFX5: NX_P48382
Post-translational modifications:
Phosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P48382
RFX5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000440.1 NP_001020774.1
ENSEMBL proteins: ENSP00000290524 ENSP00000357864 ENSP00000390769 ENSP00000389130 ENSP00000376502 ENSP00000399095 ENSP00000398666 ENSP00000409187 ENSP00000399372 ENSP00000387618 ENSP00000415012 ENSP00000396810 ENSP00000413153 ENSP00000390720 ENSP00000412900 ENSP00000405067 ENSP00000398388
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
RFX5 for ontologies About GeneDecksing
RFX5 Antibody Products:
Assay Products for RFX5: |
Protein
Domains /
Families
for RFX5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RFX5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P48382ProtoNet protein and cluster: P48382 1 Blocks protein family: IPB003150 DNA-binding RFX
UniProtKB/Swiss-Prot: RFX5_HUMAN, P48382Domain: The N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex,and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperativebinding between the RFX complex and NF-YSimilarity: Belongs to the RFX familySimilarity: Contains 1 RFX-type winged-helix DNA-binding domain |
Function
for RFX5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RFX5_HUMAN, P48382Function: Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding betweenRFX and NF-Y. RFX binds the X1 box of MHC-II promoters Genatlas biochemistry entry for RFX5:transactivating DNA binding regulatory factor 5,75kDa,involved in MHC class II expression,binding the MHC promotor boxX
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RFX5 (NM_000449) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFX5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RFX5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Rfx5tm1.1Ifo for RFX5
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rfx5):
RFX5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RFX5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Tuberculosis | | | 2 | Primary immunodeficiency | | | 3 | Allograft rejection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Kegg Pathways (Kegg details for RFX5):
RFX5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFX5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/534 Interacting proteins for RFX5 (P483821, 2, 3 ENSP000002905244) via UniProtKB, MINT, STRING, and/or I2D (see all 534)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
RFX5 for ontologies About GeneDecksing
|
Drugs & Compounds
for RFX5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RFX5
Search CenterWatch for drugs/clinical trials and news about RFX5
|
Transcripts
for RFX5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RFX5 gene (2 alternative transcripts): NM_000449.3 NM_001025603.1 Unigene Cluster for RFX5: Regulatory factor X, 5 (influences HLA class II expression) Hs.632472 [show with all ESTs]Unigene Representative Sequence: NM_00044918/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000290524(uc001exv.1 uc001exw.1 uc010pcx.1) ENST00000368870
ENST00000436637 ENST00000452671 ENST00000392746 ENST00000475144 ENST00000422595
ENST00000450506 ENST00000458484 ENST00000469513 ENST00000421986 ENST00000430227
ENST00000435314 ENST00000478564 ENST00000412774 ENST00000437327 ENST00000436271
ENST00000494217
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RFX5 (NM_000449) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFX5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX5 |
Additional cDNA sequence: AK223526.1 AK302891.1 AK309072.1 AK311525.1 AK312289.1 AL050135.1 BC017471.1 X85786.1 14 DOTS entries: DT.214919 DT.95167462 DT.70104550 DT.100814795 DT.100028565 DT.121384205 DT.95167445 DT.95167446 DT.95283447 DT.121384173 DT.121384204 DT.75103417 DT.91806607 DT.95167448 24/218 AceView cDNA sequences (see all 218): BU684818 BM987749 BQ643090 AI923771 BU508822 BM905177 AA314220 H96664 AI797342 BX415732 BQ882809 BX423384 N71762 AL040790 AI267871 AA356157 AI167924 BM704232 AA709053 BM916957 BQ436689 AW137021 CA394760 BU166686
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RFX5 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RFX5
|
Expression
for RFX5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RFX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTCATTTA
About this image
See RFX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RFX5
SOURCE GeneReport for Unigene cluster: Hs.632472
UniProtKB/Swiss-Prot: RFX5_HUMAN, P48382Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for RFX5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RFX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX5 |
Orthologs
for RFX5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RFX5 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008579121 |
DNA-binding protein RFX5-like |
59.27(n)
57.82(a) |
|
100857912 XM_003642698.1 XP_003642746.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RFX56 |
-- |
71(a) |
1 ↔ 1 |
GL343779.1(96688-100918) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.134932 |
Xenopus laevis transcribed sequence with weak similarity more |
76.76(n) |
|
BJ617558.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rfx56 |
regulatory factor X, 5 |
35(a) |
1 ↔ 1 |
19(8104467-8117542) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG97276 |
-- |
8(a) |
1 → many |
3R(2277275-2282371) |
ENSEMBL Gene Tree for RFX5 (if available)
TreeFam Gene Tree for RFX5 (if available) |
Paralogs
for RFX5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RFX5 gene
- RFX72
3 SIMAP similar genes for RFX5 using alignment to 14 protein entries: RFX5_HUMAN (see all proteins):DKFZp586K091 RFX7 RFX4
RFX5 for paralogs About GeneDecksing
|
Genomic Variants
for RFX5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RFX5 (151313116 - 151319833 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RFX5
2 CNVs: 8332 1556
Human Gene Mutation Database (HGMD): RFX5
Locus Specific Mutation Databases (LSDB): RFX5
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RFX5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RFX5 for disorders About GeneDecksing
OMIM gene information: 601863
OMIM disorders: 209920
UniProtKB/Swiss-Prot: RFX5_HUMAN, P48382
Defects in RFX5 are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditaryMHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combinedimmunodeficiency disease with early onset. It is characterized by a profound defect in constitutive andinterferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge,hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral,bacterial and fungal infections
14  diseases for RFX5: About MalaCardsbare lymphocyte syndrome bare lymphocyte syndrome, type ii, complementation group e bare lymphocyte syndrome, type ii, complementation group c mhc class ii deficiency
immunodeficiency age related macular degeneration severe combined immunodeficiency graft versus host disease
plasmodium falciparum malaria combined immunodeficiency macular degeneration malaria
tuberculosis acute graft versus host disease
1 disease from the University of Copenhagen DISEASES database for RFX5:Severe combined immunodeficiency 3 Novoseek disease relationships for RFX5 gene About this table
Human Genome Epidemiology (HuGE) Navigator: RFX5 (2 documents)
Export disorders for RFX5 gene to outside databases
|
Publications
for RFX5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RFX5 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with RFX5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y. (PubMed id 10779326)1, 2, 9 Villard J.... Reith W. (2000)
- Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency. (PubMed id 9401005)1, 3, 9 Villard J....Mach B. (1997)
- A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). (PubMed id 7744245)1, 2, 9 Steimle V....Reith W. (1995)
- Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex. (PubMed id 10825209)1, 2, 9 Nekrep N.... Peterlin B.M. (2000)
- Sequence-specific recognition of a PxLPxI/L motif by a n ankyrin repeat tumbler lock. (PubMed id 22649097)1, 2 Xu C....Min J. (2012)
- Solution structure of the heterotrimeric complex betw een the interaction domains of RFX5 and RFXAP from the RFX gene regulatory comp lex. (PubMed id 20732328)1, 2 Laird K.M....Garvie C.W. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. (PubMed id 10072068)1, 2 Nagarajan U.M....Boss J.M. (1999)
- Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. (PubMed id 9177217)1, 9 Scholl T....Strominger J.L. (1997)
|
External Searches for RFX5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RFX5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RFX5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RFX5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RFX5 | Pharmacogenomics, SNPs, Pathways | | RFX5base | http://bioinf.uta.fi/RFX5base/ |
|
| | |
About This Section
| Patent Information for RFX5 gene:
Search GeneIP for patents involving RFX5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RFX5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RFX5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFX5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX5 | | | OriGene Protein Over-expression Lysate for RFX5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RFX5 | | OriGene 3'-UTR Clone for RFX5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RFX5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RFX5 | | OriGene Custom Protein Services for RFX5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RFX5 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFX5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX5 |
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| | | | Search Tocris compounds for RFX5 |
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 | | | RFX5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX5 |
|  |  |  | | | | ThermoFisher Antibodies for RFX5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX5 |
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