Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFX4 Gene

protein-coding   GIFtS: 54
GCID: GC12P106976

regulatory factor X, 4 (influences HLA class II expression)
 Explore 4 diseases affiliated with
RFX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RFX4    

Aliases
for RFX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulatory Factor X, 4 (Influences HLA Class II Expression)1 2
Testis Development Protein NYD-SP102 3
NYD-SP102
Transcription Factor RFX42
Winged-Helix Transcription Factor RFX42
Regulatory Factor X 43

External Ids:    HGNC: 99851   Entrez Gene: 59922   Ensembl: ENSG000001117837   OMIM: 6039585   UniProtKB: Q33E943   

Export aliases for RFX4 gene to outside databases

Previous GC identifers: GC12P106105 GC12P106875 GC12P105497 GC12P105479 GC12P104037


Summaries
for RFX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RFX4:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a
highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to
regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2
and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
Function: May activate transcription by interacting directly with the X-box (By similarity)

Gene Wiki entry for RFX4


Genomic Views
for RFX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFX4 gene promoter:
         USF1   Sox5   NF-1   Spz1   USF-1   Tal-1beta   ITF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RFX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for RFX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24

RFX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFX4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P106976:  view genomic region     (about GC identifiers)

Start:
 106,976,685 bp from pter      End:
 107,156,581 bp from pter
Size:
 179,897 bases      Orientation:
 plus strand

Proteins
for RFX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94 (See protein sequence)
Recommended Name: Transcription factor RFX4  
Size: 735 amino acids; 83368 Da
Subunit: Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAB59001.1; Type=Miscellaneous discrepancy; Note=Probable intron retention;
Sequence=BAC11288.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48237.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48238.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: A8K5Y0 B2RDW4 Q33DW6 Q33DW7 Q33E95 Q6YM53 Q8MHQ1 Q8NC78 Q8NDF9 Q8SNA1 Q96S80
Q9BXI0
Alternative splicing: 4 isoforms:  Q33E94-1   Q33E94-2   Q33E94-3   Q33E94-4   

Explore the universe of human proteins at neXtProt for RFX4: NX_Q33E94

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q33E94

    • RFX4 Protein expression data from MOPED and PaxDb:    About this image 
    RFX4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001193620.1  NP_115880.2  NP_998759.1  

    ENSEMBL proteins: 
     ENSP00000376585   ENSP00000447423   ENSP00000447735   ENSP00000350552   ENSP00000444163  
     ENSP00000448694   ENSP00000447904   ENSP00000229387   ENSP00000449732  

    Human Recombinant Protein Products for RFX4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RFX4
    OriGene Custom Protein Services for RFX4 
    GenScript Custom Purified and Recombinant Proteins Services for RFX4
    Novus Biologicals RFX4 Proteins
    Novus Biologicals RFX4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RFX4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    RFX4 for ontologies           About GeneDecksing



    RFX4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RFX4
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RFX4 
    GenScript Custom Superior Antibodies Services for RFX4
    Novus Biologicals RFX4 Antibodies
    Abcam antibodies for RFX4 
    Uscn Antibodies for RFX4
    Search ThermoFisher Antibodies for RFX4

    Assay Products for RFX4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RFX4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RFX4

    Protein Domains /
    Families
    for RFX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RFX4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR003150 DNA-bd_RFX

    Graphical View of Domain Structure for InterPro Entry Q33E94

    ProtoNet protein and cluster: Q33E94

    1 Blocks protein family: IPB003150 DNA-binding RFX

    UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
    Similarity: Belongs to the RFX family
    Similarity: Contains 1 RFX-type winged-helix DNA-binding domain


    Function
    for RFX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFX4_HUMAN, Q33E94
    Function: May activate transcription by interacting directly with the X-box (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
         
    RFX4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RFX4:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rfx4):
     embryogenesis  mortality/aging  nervous system 

    RFX4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RFX4 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): RFX4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFX4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX4 (see all 19):
    hsa-miR-495 hsa-miR-3660 hsa-miR-374a hsa-miR-216b hsa-miR-944 hsa-miR-3692 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RFX4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFX4 (see all 4)
    OriGene shRNA RFP: RFX4
    OriGene siRNA: RFX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX4
    Sirion Biotech Custom design and validation of potent shRNA sequences against RFX4 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RFX4
    Sirion Biotech Customized adenovirus for overexpression of RFX4 
    Sirion Biotech Customized adenovirus for potent knockdown of RFX4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX4 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): RFX4 (NM_213594)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RFX4
    Search LifeMap BioReagents cell lines for RFX4
    Sirion Biotech Customized stable knockdown cell line services for RFX4 
    Sirion Biotech Customized inducible knockdown cell line services for RFX4
    Sirion Biotech Customized stable overexpressing cell line services for RFX4
    Sirion Biotech Customized inducible overexpressing cell line services for RFX4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX4


    Pathways & Interactions
    for RFX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RFX4
        Transcriptional Regulatory Network in Embryonic Stem Cell


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFX4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/51 Interacting proteins for RFX4 (Q33E943 ENSP000003765854) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0021516dorsal spinal cord development IEA--
    GO:0021696cerebellar cortex morphogenesis IEA--

    RFX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RFX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RFX4
    Search CenterWatch for drugs/clinical trials and news about RFX4 

    Transcripts
    for RFX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RFX4 gene (4 alternative transcripts): 
    NM_001206691.1  NM_032491.5  NM_213594.2  NM_002920.3  

    Unigene Cluster for RFX4:

    Regulatory factor X, 4 (influences HLA class II expression)
    Hs.388827  [show with all ESTs]
    Unigene Representative Sequence: NM_213594
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392842(uc001tlr.3 uc001tlt.3) ENST00000546882 ENST00000549040
    ENST00000539967 ENST00000357881(uc010swv.2) ENST00000536722 ENST00000536688(uc001tls.3)
    ENST00000552773 ENST00000551640 ENST00000552866 ENST00000229387(uc001tlv.3)
    ENST00000552917

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): RFX4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFX4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX4 (see all 19):
    hsa-miR-495 hsa-miR-3660 hsa-miR-374a hsa-miR-216b hsa-miR-944 hsa-miR-3692 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RFX4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFX4 (see all 4)
    OriGene shRNA RFP: RFX4
    OriGene siRNA: RFX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX4
    Sirion Biotech Custom design and validation of potent shRNA sequences against RFX4 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX4 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): RFX4 (NM_213594)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RFX4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX4

    Additional cDNA sequence: 

    AB044245.1 AB095365.1 AB095366.1 AB195784.1 AB195785.1 AF332192.1 AK074913.1 AK291445.1 
    AK315698.1 AL833921.1 AY102009.1 BC028582.2 BC030644.1 

    12 DOTS entries:

    DT.114250  DT.97811586  DT.91676587  DT.121150770  DT.121150588  DT.100773917  DT.121150546  DT.121150689 
    DT.453985  DT.95069337  DT.40316652  DT.95082515 

    24/80 AceView cDNA sequences (see all 80):

    F07873 NM_002920 Z42852 NM_032491 F04136 AA983818 AB044245 Z42633 
    AK074913 F07362 NM_213594 BC030644 AL833921 F02320 AY102009 BC028582 
    BG152590 AA885061 AI191585 BI460034 BG720172 BI464065 CD557094 BG772831 

    GeneLoc Exon Structure


    Expression
    for RFX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTTTGCTTT
    RFX4 Expression
    About this image

    RFX4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    BrainMedulla OblongataBrain
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RFX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RFX4

    SOURCE GeneReport for Unigene cluster: Hs.388827

    UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
    Tissue specificity: Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3
    are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at
    a higher level in adult testes and ejaculated spematozoa than in fetal testes

        SABiosciences Custom PCR Arrays for RFX4
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RFX4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX4

    Orthologs
    for RFX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RFX4 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RFX41 regulatory factor X, 4 (influences HLA class II expression) 83.66(n)
    95.56(a)    		   418070  XM_416306.3  XP_416306.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RFX46
    		 --
    		 93(a)
    		 1 ↔ 1
    		 5(19285828-19332637)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.49202 Transcribed sequences 76.87(n)    BQ391290.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.205432 Danio rerio winged-helix transcription factor RFX4 more 77.27(n)    AY102011.1 


    ENSEMBL Gene Tree for RFX4 (if available)
    TreeFam Gene Tree for RFX4 (if available) 

    Paralogs
    for RFX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFX4 gene
    RFX12  RFX62  RFX32  RFX82  RFX22  
    6 SIMAP similar genes for RFX4 using alignment to 7 protein entries:     RFX4_HUMAN (see all proteins):
    RFX7    RFX5    RFX2    RFX8    RFX3    RFX6

    RFX4 for paralogs           About GeneDecksing



    Genomic Variants
    for RFX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2685 NCBI SNPs in RFX4 are shown (see all 2685)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs342327171,2
    		C--104094970(+) TTTTT-/TGAGGT 1 -- int12Minor allele frequency- T:0.25NA 4
    rs1395107391,2
    		--106974695(+) GTGACC/TGCCAC 2 -- int1 us2k10--------
    rs1861892731,2
    		--106974808(+) GTGGTG/TAACAA 2 -- int1 us2k10--------
    rs1149412231,2
    		--106974819(+) AGTCCT/CCCAGA 2 -- int1 us2k11Minor allele frequency- C:0.01WA 118
    rs1910034001,2
    		--106974827(+) AGAAAC/TAAACC 2 -- int1 us2k10--------
    rs1177342011,2
    		F--106974857(+) GGCCGG/AGGCAG 2 -- us2k1 int11Minor allele frequency- A:0.02NA 120
    rs1127406491,2
    		--106975027(+) TTTATG/AACCAC 2 -- us2k1 int11Minor allele frequency- A:0.50CSA 2
    rs1179506971,2
    		F--106975339(+) GATCGC/AGGAAA 2 -- us2k1 int11Minor allele frequency- A:0.15NA 120
    rs128094891,2
    		C--106975354(+) CGCGCA/TGCCAG 2 -- us2k1 int18Minor allele frequency- T:0.08NA CSA WA 248
    rs128321271,2
    		C,F--106975388(+) CTCCCG/ACACGG 2 -- int1 us2k17Minor allele frequency- A:0.40NA CSA WA 248

    HapMap Linkage Disequilibrium report for RFX4 (106976685 - 107156581 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RFX4
         1 CNV: 30610
         1 Indel: 39934

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFX4
    DNA2.0 Custom Variant and Variant Library Synthesis for RFX4

    Disorders / Diseases
    for RFX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RFX4 for disorders           About GeneDecksing

    OMIM gene information: 603958    OMIM disorders: --

    4 diseases for RFX4:    About MalaCards
    situs inversus    brain glioma    parkinson's disease    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RFX4:
    Hydrocephalus
    Genetic Association Database (GAD): RFX4
    Human Genome Epidemiology (HuGE) Navigator: RFX4 (4 documents)

    Export disorders for RFX4 gene to outside databases

    Publications
    for RFX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RFX4 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with RFX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. (PubMed id 11682486)1, 2, 3, 9 Morotomi-Yano K....Miki Y. (2002)
    2. Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients. (PubMed id 16271074)1, 2, 9 Matsushita H.... Nakayama E. (2005)
    3. Identification of a novel substrate for tyrosine kinase in human testes. (PubMed id 16193984)1, 2, 9 Huang X....Sha J. (2005)
    4. Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. (PubMed id 15940297)1, 4 Glaser B....Owen M.J. (2005)
    5. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. (PubMed id 12925582)1, 2 Blackshear P.J.... Zeldin D.C. (2003)
    6. RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. (PubMed id 8600444)1, 3 Emery P....Reith W. (1996)
    7. Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. (PubMed id 16893423)1, 9 Zhang D....Blackshear P.J. (2006)
    8. Genome-wide association study confirms BST1 and sugge sts a locus on 12q24 as the risk loci for Parkinson's disease in the European p opulation. (PubMed id 21084426)1 Saad M....Brice A. (2010)
    9. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1 Yosifova A....Nakamura Y. (2009)
    10. Immune transcriptome alterations in the temporal cort ex of subjects with autism. (PubMed id 18378158)1 Garbett K....Persico A.M. (2008)

    External Searches for RFX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RFX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5992 HGNC: 9985 AceView: RFX4 Ensembl:ENSG00000111783 euGenes: HUgn5992
    ECgene: RFX4 H-InvDB: RFX4

    Other Databases showing RFX4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RFX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RFX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RFX4 gene:
    Search GeneIP for patents involving RFX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RFX4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RFX4
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RFX4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFX4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX4  
     OriGene Protein Over-expression Lysate for RFX4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RFX4   OriGene 3'-UTR Clone for RFX4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFX4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFX4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RFX4   OriGene Custom Protein Services for RFX4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RFX4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFX4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX4
     GenScript Custom Purified and Recombinant Proteins Services for RFX4 GenScript cDNA clones with any tag delivered in your preferred vector for RFX4
     GenScript Custom Assay Services for RFX4 GenScript Custom Superior Antibodies Services for RFX4
     GenScript Custom overexpressing Cell Line Services for RFX4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RFX4 promoter
     Search Chromatin IP Primers for RFX4
     RT2 qPCR Primer Assay in human, mouse, rat RFX4
     GNC Network for RFX4
     SABiosciences PCR Arrays including human, mouse, rat RFX4
     Search Tocris compounds for RFX4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RFX4 antibodies
     RFX4 proteins
     RFX4 lysates
     Antibodies for RFX4
     See all of Abcam's Antibodies, Kits and Proteins for RFX4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RFX4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RFX4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX4
     SwitchGear 3'UTR luciferase reporter plasmids for RFX4
     SwitchGear Promoter luciferase reporter plasmids for RFX4
     Search ThermoFisher Antibodies for RFX4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX4
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RFX4
    Sirion Biotech Customized:
     stable knockdown cell line services for RFX4
     inducible knockdown cell line services for RFX4
     design and validation of potent shRNA sequences against RFX4
     adenovirus for potent knockdown of RFX4
     adenovirus for overexpression of RFX4
     stable overexpressing cell line services for RFX4
     inducible overexpressing cell line services for RFX4
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RFX4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4