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RFX4 Gene

protein-coding   GIFtS: 54
GCID: GC12P106976

Regulatory Factor X, 4 (Influences HLA Class II Expression)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulatory Factor X, 4 (Influences HLA Class II Expression)1 2
Testis Development Protein NYD-SP102 3
NYD-SP102
Transcription Factor RFX42
Winged-Helix Transcription Factor RFX42
Regulatory Factor X 43

External Ids:    HGNC: 99851   Entrez Gene: 59922   Ensembl: ENSG000001117837   OMIM: 6039585   UniProtKB: Q33E943   

Export aliases for RFX4 gene to outside databases

Previous GC identifers: GC12P106105 GC12P106875 GC12P105497 GC12P105479 GC12P104037


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RFX4 Gene:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a
highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to
regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory
factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, May 2011)

GeneCards Summary for RFX4 Gene:
RFX4 (regulatory factor X, 4 (influences HLA class II expression)) is a protein-coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is RFX6.

UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
Function: May activate transcription by interacting directly with the X-box (By similarity)

Gene Wiki entry for RFX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RFX4 gene promoter:
         USF1   Sox5   NF-1   Spz1   USF-1   Tal-1beta   ITF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFX4 promoter sequence
   Search Chromatin IP Primers for RFX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24

RFX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFX4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P106976:  view genomic region     (about GC identifiers)

Start:
106,976,685 bp from pter      End:
107,156,582 bp from pter
Size:
179,898 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94 (See protein sequence)
Recommended Name: Transcription factor RFX4  
Size: 735 amino acids; 83368 Da
Subunit: Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA
Sequence caution: Sequence=BAB59001.1; Type=Miscellaneous discrepancy; Note=Probable intron retention;
Sequence=BAC11288.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48237.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48238.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5Y0 B2RDW4 Q33DW6 Q33DW7 Q33E95 Q6YM53 Q8MHQ1 Q8NC78 Q8NDF9 Q8SNA1
Q96S80 Q9BXI0
Alternative splicing: 4 isoforms:  Q33E94-1   Q33E94-2   Q33E94-3   Q33E94-4   

Explore the universe of human proteins at neXtProt for RFX4: NX_Q33E94

Explore proteomics data for RFX4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RFX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193620.1  NP_115880.2  NP_998759.1  

    ENSEMBL proteins: 
     ENSP00000376585   ENSP00000447423   ENSP00000447735   ENSP00000473326   ENSP00000350552  
     ENSP00000444163   ENSP00000448694   ENSP00000447904   ENSP00000229387   ENSP00000449732  

    RFX4 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFX4

     
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    antibodies-online proteins for RFX4 (4 products) 

     
    antibodies-online peptides for RFX4

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    antibodies-online antibodies for RFX4 (24 products) 

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    antibodies-online kits for RFX4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003150 DNA-bd_RFX

    Graphical View of Domain Structure for InterPro Entry Q33E94

    ProtoNet protein and cluster: Q33E94

    1 Blocks protein domain: IPB003150 DNA-binding RFX

    UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
    Similarity: Belongs to the RFX family
    Similarity: Contains 1 RFX-type winged-helix DNA-binding domain


    Find genes that share domains with RFX4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFX4_HUMAN, Q33E94
    Function: May activate transcription by interacting directly with the X-box (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RFX4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RFX4:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rfx4):
     embryogenesis  mortality/aging  nervous system 

    Find genes that share phenotypes with RFX4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RFX4

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RFX4 (see all 19):
    hsa-miR-495 hsa-miR-3660 hsa-miR-374a hsa-miR-216b hsa-miR-944 hsa-miR-3692 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RFX4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFX4_HUMAN, Q33E94: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with RFX4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RFX4 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RFX4
        Transcriptional Regulatory Network in Embryonic Stem Cell


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFX4
    Interactions:

        GeneGlobe Interaction Network for RFX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for RFX4 (Q33E943 ENSP000003765854) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0021516dorsal spinal cord development IEA--
    GO:0021696cerebellar cortex morphogenesis IEA--

    Find genes that share ontologies with RFX4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RFX4 gene (4 alternative transcripts): 
    NM_001206691.1  NM_032491.5  NM_213594.2  NM_002920.3  

    Unigene Cluster for RFX4:

    Regulatory factor X, 4 (influences HLA class II expression)
    Hs.388827  [show with all ESTs]
    Unigene Representative Sequence: NM_213594
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392842(uc001tlr.3 uc001tlt.3) ENST00000546882 ENST00000549040
    ENST00000539967 ENST00000357881(uc010swv.2) ENST00000536722 ENST00000536688(uc001tls.3)
    ENST00000552773 ENST00000551640 ENST00000552866 ENST00000229387(uc001tlv.3)
    ENST00000552917
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RFX4 (see all 19):
    hsa-miR-495 hsa-miR-3660 hsa-miR-374a hsa-miR-216b hsa-miR-944 hsa-miR-3692 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RFX4 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX4
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RFX4
      QuantiFast Probe-based Assays in human, mouse, rat RFX4

    Additional mRNA sequence: 

    AB044245.1 AB095365.1 AB095366.1 AB195784.1 AB195785.1 AF332192.1 AK074913.1 AK291445.1 
    AK315698.1 AL833921.1 AY102009.1 BC028582.2 BC030644.1 

    12 DOTS entries:

    DT.114250  DT.97811586  DT.91676587  DT.121150770  DT.121150588  DT.100773917  DT.121150546  DT.121150689 
    DT.453985  DT.95069337  DT.40316652  DT.95082515 

    Selected AceView cDNA sequences (see all 80):

    AY102009 BC030644 AB044245 F04136 AL833921 AA983818 NM_032491 F02320 
    NM_213594 F07873 Z42852 F07362 Z42633 BC028582 AK074913 NM_002920 
    AA983393 Z38801 BE855589 AF332192 AW592045 AA906504 BG772873 CD358302 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RFX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTGCTTT
    RFX4 Expression
    About this image


    RFX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     NULL (Uncategorized)
             Neural rosettes
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    RFX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388827

    UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
    Tissue specificity: Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and
    isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3
    is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RFX4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfx41 , 5 regulatory factor X, 4 (influences HLA class II expression)1, 5 90.39(n)1
    97.14(a)1
      10 (41.63 cM)5
    711371  NM_001024918.11  NP_001020089.11 
     847560625 
    chicken
    (Gallus gallus)
    Aves RFX41 regulatory factor X, 4 (influences HLA class II expression) 83.66(n)
    95.56(a)
      418070  XM_004937812.1  XP_004937869.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFX46
    regulatory factor X, 4 (influences HLA class II ex...
    93(a)
    1 ↔ 1
    5(19285828-19332637)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.49202 Transcribed sequences 76.87(n)    BQ391290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.205432 Danio rerio winged-helix transcription factor RFX4 more 77.27(n)    AY102011.1 
    worm
    (Caenorhabditis elegans)
    Secernentea daf-196
    Protein DAF-19, isoform b
    21(a)
    1 → many
    II(10157537-10169321) WBGene00000914


    ENSEMBL Gene Tree for RFX4 (if available)
    TreeFam Gene Tree for RFX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RFX4 gene
    RFX62  RFX12  RFX32  RFX82  RFX22  
    6 SIMAP similar genes for RFX4 using alignment to 8 protein entries:     RFX4_HUMAN (see all proteins):
    RFX7    RFX5    RFX2    RFX8    RFX3    RFX6

    Find genes that share paralogs with RFX4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for RFX4    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0378734
    ----see VAR_0378732 S N mis40--------
    rs170387661,2,4
    ----see VAR_0571522 mis40--------

    HapMap Linkage Disequilibrium report for RFX4 (106976685 - 107156582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RFX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269609CNV Insertion20981092
    esv990753CNV Insertion20482838
    nsv522964CNV Loss19592680
    nsv899505CNV Gain21882294
    nsv9005CNV Gain18304495
    nsv832511CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603958    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RFX4:
    Hydrocephalus

    Find genes that share disorders with RFX4           About GenesLikeMe

    Genetic Association Database (GAD): RFX4
    Human Genome Epidemiology (HuGE) Navigator: RFX4 (4 documents)

    Export disorders for RFX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFX4 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RFX4)
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    1. Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA- binding protein that cooperates with other human RFX members. (PubMed id 11682486)1, 2, 3, 9 Morotomi-Yano K.... Miki Y. (J. Biol. Chem. 2002)
    2. Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients. (PubMed id 16271074)1, 2, 9 Matsushita H.... Nakayama E. (Cancer Sci. 2005)
    3. Identification of a novel substrate for tyrosine kinase in human testes. (PubMed id 16193984)1, 2, 9 Huang X.... Sha J. (J. Nanosci. Nanotechnol. 2005)
    4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)1, 4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    6. Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. (PubMed id 15940297)1, 4 Glaser B....Owen M.J. (Mol. Psychiatry 2005)
    7. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. (PubMed id 12925582)1, 2 Blackshear P.J.... Zeldin D.C. (Development 2003)
    8. RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. (PubMed id 8600444)1, 3 Emery P....Reith W. (Nucleic Acids Res. 1996)
    9. Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. (PubMed id 16893423)1, 9 Zhang D....Blackshear P.J. (J. Neurochem. 2006)
    10. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5992 HGNC: 9985 AceView: RFX4 Ensembl:ENSG00000111783 euGenes: HUgn5992
    ECgene: RFX4 H-InvDB: RFX4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RFX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RFX4 gene:
    Search GeneIP for patents involving RFX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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