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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFX4 Gene

protein-coding   GIFtS: 55
GCID: GC12P106976

Regulatory Factor X, 4 (Influences HLA Class II Expression)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulatory Factor X, 4 (Influences HLA Class II Expression)1 2
Testis Development Protein NYD-SP102 3
NYD-SP102
Transcription Factor RFX42
Winged-Helix Transcription Factor RFX42
Regulatory Factor X 43

External Ids:    HGNC: 99851   Entrez Gene: 59922   Ensembl: ENSG000001117837   OMIM: 6039585   UniProtKB: Q33E943   

Export aliases for RFX4 gene to outside databases

Previous GC identifers: GC12P106105 GC12P106875 GC12P105497 GC12P105479 GC12P104037


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RFX4 Gene:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a
highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to
regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory
factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, May 2011)

GeneCards Summary for RFX4 Gene: 
RFX4 (regulatory factor X, 4 (influences HLA class II expression)) is a protein-coding gene. Diseases associated with RFX4 include brain glioma, and situs inversus. GO annotations related to this gene include chromatin binding and DNA binding. An important paralog of this gene is RFX6.

UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
Function: May activate transcription by interacting directly with the X-box (By similarity)

Gene Wiki entry for RFX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFX4 gene promoter:
         USF1   Sox5   NF-1   Spz1   USF-1   Tal-1beta   ITF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for RFX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24

RFX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFX4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P106976:  view genomic region     (about GC identifiers)

Start:
106,976,685 bp from pter      End:
107,156,582 bp from pter
Size:
179,898 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94 (See protein sequence)
Recommended Name: Transcription factor RFX4  
Size: 735 amino acids; 83368 Da
Subunit: Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAB59001.1; Type=Miscellaneous discrepancy; Note=Probable intron retention;
Sequence=BAC11288.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48237.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48238.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5Y0 B2RDW4 Q33DW6 Q33DW7 Q33E95 Q6YM53 Q8MHQ1 Q8NC78 Q8NDF9 Q8SNA1
Q96S80 Q9BXI0
Alternative splicing: 4 isoforms:  Q33E94-1   Q33E94-2   Q33E94-3   Q33E94-4   

Explore the universe of human proteins at neXtProt for RFX4: NX_Q33E94

Explore proteomics data for RFX4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q33E94

  • RFX4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RFX4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001193620.1  NP_115880.2  NP_998759.1  

    ENSEMBL proteins: 
     ENSP00000376585   ENSP00000447423   ENSP00000447735   ENSP00000473326   ENSP00000350552  
     ENSP00000444163   ENSP00000448694   ENSP00000447904   ENSP00000229387   ENSP00000449732  

    Human Recombinant Protein Products for RFX4: 
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    Novus Biologicals RFX4 Proteins
    Novus Biologicals RFX4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFX4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    RFX4 for ontologies           About GeneDecksing



    RFX4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003150 DNA-bd_RFX

    Graphical View of Domain Structure for InterPro Entry Q33E94

    ProtoNet protein and cluster: Q33E94

    1 Blocks protein domain: IPB003150 DNA-binding RFX

    UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
    Similarity: Belongs to the RFX family
    Similarity: Contains 1 RFX-type winged-helix DNA-binding domain


    RFX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFX4_HUMAN, Q33E94
    Function: May activate transcription by interacting directly with the X-box (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
         
    RFX4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RFX4:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rfx4):
     embryogenesis  mortality/aging  nervous system 

    RFX4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RFX4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RFX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFX4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFX4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFX4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX4 (see all 19):
    hsa-miR-495 hsa-miR-3660 hsa-miR-374a hsa-miR-216b hsa-miR-944 hsa-miR-3692 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RFX4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RFX4

    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RFX4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RFX4
        Transcriptional Regulatory Network in Embryonic Stem Cell


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFX4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/51 Interacting proteins for RFX4 (Q33E943 ENSP000003765854) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0021516dorsal spinal cord development IEA--
    GO:0021696cerebellar cortex morphogenesis IEA--

    RFX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RFX4

    Search CenterWatch for drugs/clinical trials and news about RFX4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RFX4 gene (4 alternative transcripts): 
    NM_001206691.1  NM_032491.5  NM_213594.2  NM_002920.3  

    Unigene Cluster for RFX4:

    Regulatory factor X, 4 (influences HLA class II expression)
    Hs.388827  [show with all ESTs]
    Unigene Representative Sequence: NM_213594
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392842(uc001tlr.3 uc001tlt.3) ENST00000546882 ENST00000549040
    ENST00000539967 ENST00000357881(uc010swv.2) ENST00000536722 ENST00000536688(uc001tls.3)
    ENST00000552773 ENST00000551640 ENST00000552866 ENST00000229387(uc001tlv.3)
    ENST00000552917

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFX4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX4 (see all 19):
    hsa-miR-495 hsa-miR-3660 hsa-miR-374a hsa-miR-216b hsa-miR-944 hsa-miR-3692 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RFX4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RFX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX4
    Clone
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    OriGene ORF clones in mouse, rat for RFX4
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    GenScript: all cDNA clones in your preferred vector (see all 3): RFX4 (NM_213594)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX4
    Sirion Biotech Customized lentivirus for stable overexpression of RFX4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX4

    Additional mRNA sequence: 

    AB044245.1 AB095365.1 AB095366.1 AB195784.1 AB195785.1 AF332192.1 AK074913.1 AK291445.1 
    AK315698.1 AL833921.1 AY102009.1 BC028582.2 BC030644.1 

    12 DOTS entries:

    DT.114250  DT.97811586  DT.91676587  DT.121150770  DT.121150588  DT.100773917  DT.121150546  DT.121150689 
    DT.453985  DT.95069337  DT.40316652  DT.95082515 

    24/80 AceView cDNA sequences (see all 80):

    Z42852 AB044245 F04136 NM_213594 AL833921 NM_032491 NM_002920 AY102009 
    AA983818 F02320 BC028582 F07362 AK074913 F07873 Z42633 BC030644 
    BG152590 BG772831 AA983393 Z40423 BE857075 BI562672 BI460208 AW592045 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFX4 expression in normal human tissues (normalized intensities)      RFX4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTGCTTT
    RFX4 Expression
    About this image


    RFX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
             skeletal muscle ; myocytes   
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   
     
     Smooth Muscle (Muscoskeletal System)
             smooth muscle ; smooth muscle cells   

    See RFX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RFX4

    SOURCE GeneReport for Unigene cluster: Hs.388827

    UniProtKB/Swiss-Prot: RFX4_HUMAN, Q33E94
    Tissue specificity: Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and
    isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3
    is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RFX4 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfx41 , 5 regulatory factor X, 4 (influences HLA class II expression)1, 5 90.18(n)1
    97.1(a)1
      10 (41.63 cM)5
    711371  NM_001024918.11  NP_001020089.11 
     847560625 
    chicken
    (Gallus gallus)
    Aves RFX41 regulatory factor X, 4 (influences HLA class II expression) 83.66(n)
    95.56(a)
      418070  XM_416306.3  XP_416306.2 
    lizard
    (Anolis carolinensis)
    Reptilia RFX46
    Uncharacterized protein
    93(a)
    1 ↔ 1
    5(19285828-19332637)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.49202 Transcribed sequences 76.87(n)    BQ391290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.205432 Danio rerio winged-helix transcription factor RFX4 more 77.27(n)    AY102011.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RFX16
    Major transcriptional repressor of DNA-damage-regu...
    11(a)
    1 → many
    XII(507797-510232)


    ENSEMBL Gene Tree for RFX4 (if available)
    TreeFam Gene Tree for RFX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFX4 gene
    RFX62  RFX12  RFX32  RFX82  RFX22  
    6 SIMAP similar genes for RFX4 using alignment to 8 protein entries:     RFX4_HUMAN (see all proteins):
    RFX7    RFX5    RFX2    RFX8    RFX3    RFX6

    RFX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in RFX4 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0378734
    ----see VAR_0378732 S N mis40--------
    VAR_0571524
    ----see VAR_0571522 S A mis40--------

    HapMap Linkage Disequilibrium report for RFX4 (106976685 - 107156582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RFX4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv269609CNV Insertion20981092
    esv990753CNV Insertion20482838
    nsv522964CNV Loss19592680
    nsv899505CNV Gain21882294
    nsv9005CNV Gain18304495
    nsv832511CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RFX4
    DNA2.0 Custom Variant and Variant Library Synthesis for RFX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603958    OMIM disorders: --

    5 diseases for RFX4:    About MalaCards
    brain glioma    situs inversus    hydrocephalus    parkinson's disease
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RFX4:
    Hydrocephalus

    RFX4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): RFX4
    Human Genome Epidemiology (HuGE) Navigator: RFX4 (4 documents)

    Export disorders for RFX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RFX4 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RFX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. (PubMed id 11682486)1, 2, 3, 9 Morotomi-Yano K....Miki Y. (2002)
    2. Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients. (PubMed id 16271074)1, 2, 9 Matsushita H.... Nakayama E. (2005)
    3. Identification of a novel substrate for tyrosine kinase in human testes. (PubMed id 16193984)1, 2, 9 Huang X....Sha J. (2005)
    4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (2009)
    5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)1, 4 Seshadri S....Wolf P.A. (2007)
    6. Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. (PubMed id 15940297)1, 4 Glaser B....Owen M.J. (2005)
    7. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. (PubMed id 12925582)1, 2 Blackshear P.J.... Zeldin D.C. (2003)
    8. RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. (PubMed id 8600444)1, 3 Emery P....Reith W. (1996)
    9. Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. (PubMed id 16893423)1, 9 Zhang D....Blackshear P.J. (2006)
    10. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5992 HGNC: 9985 AceView: RFX4 Ensembl:ENSG00000111783 euGenes: HUgn5992
    ECgene: RFX4 H-InvDB: RFX4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RFX4 gene:
    Search GeneIP for patents involving RFX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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