Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RFX3 Gene

protein-coding   GIFtS: 57
GCID: GC09M003214

Regulatory Factor X, 3 (Influences HLA Class II Expression)

  See RFX3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Regulatory Factor X, 3 (Influences HLA Class II Expression)1 2
DNA Binding Protein RFX32
Transcription Factor RFX32
Regulatory Factor X 33

External Ids:    HGNC: 99841   Entrez Gene: 59912   Ensembl: ENSG000000802987   OMIM: 6013375   UniProtKB: P483803   

Export aliases for RFX3 gene to outside databases

Previous GC identifers: GC09M003378 GC09M003205


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RFX3 Gene:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a
highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to
regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a
heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for RFX3 Gene:
RFX3 (regulatory factor X, 3 (influences HLA class II expression)) is a protein-coding gene. Diseases associated with RFX3 include chordoid glioma, and pineoblastoma. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RFX6.

UniProtKB/Swiss-Prot: RFX3_HUMAN, P48380
Function: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas
development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during
embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile
cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in
ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By
similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during
endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates
transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of
target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in
neuronal cells

Gene Wiki entry for RFX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RFX3 gene promoter:
         E2F-4   E2F-3a   E2F-5   FOXD3   Nkx2-5   E2F-2   C/EBPalpha   AREB6   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFX3 promoter sequence
   Search Chromatin IP Primers for RFX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.2   Ensembl cytogenetic band:  9p24.2   HGNC cytogenetic band: 9p24.2

RFX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFX3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M003214:  view genomic region     (about GC identifiers)

Start:
3,218,297 bp from pter      End:
3,526,004 bp from pter
Size:
307,708 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RFX3_HUMAN, P48380 (See protein sequence)
Recommended Name: Transcription factor RFX3  
Size: 749 amino acids; 83530 Da
Secondary accessions: A8K0H5 D3DRH8 D3DRH9 Q5JTL7 Q5JTL8 Q6NW13 Q8WTU4 Q95HL5 Q95HL6
Alternative splicing: 3 isoforms:  P48380-1   P48380-2   P48380-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RFX3: NX_P48380

Explore proteomics data for RFX3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RFX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269045.1  NP_001269046.1  NP_002910.1  NP_602304.1  

    ENSEMBL proteins: 
     ENSP00000371434   ENSP00000351574   ENSP00000415594   ENSP00000400026   ENSP00000405664  
     ENSP00000411756   ENSP00000410988   ENSP00000416189   ENSP00000399352   ENSP00000371414  
     ENSP00000303847  

    RFX3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RFX3
    OriGene Protein Over-expression Lysate for RFX3
    OriGene MassSpec for RFX3
    OriGene Custom Protein Services for RFX3
    GenScript Custom Purified and Recombinant Proteins Services for RFX3
    Novus Biologicals RFX3 Protein
    Novus Biologicals RFX3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFX3

     
    Search eBioscience for Proteins for RFX3 

     
    antibodies-online proteins for RFX3 (4 products) 

     
    antibodies-online peptides for RFX3

    RFX3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RFX3
    OriGene Custom Antibody Services for RFX3
    Novus Biologicals RFX3 Antibodies
    Abcam antibodies for RFX3
    Cloud-Clone Corp. Antibodies for RFX3
    ThermoFisher Antibodies for RFX3
    antibodies-online antibodies for RFX3 (24 products) 

    RFX3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RFX3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RFX3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RFX3
    Cloud-Clone Corp. CLIAs for RFX3
    Search eBioscience for ELISAs for RFX3 
    antibodies-online kits for RFX3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003150 DNA-bd_RFX
     IPR007668 RFX1_trans_act

    Graphical View of Domain Structure for InterPro Entry P48380

    ProtoNet protein and cluster: P48380

    2 Blocks protein domains:
    IPB003150 DNA-binding RFX
    IPB007668 RFX1 transcription activation region


    UniProtKB/Swiss-Prot: RFX3_HUMAN, P48380
    Similarity: Belongs to the RFX family
    Similarity: Contains 1 RFX-type winged-helix DNA-binding domain


    Find genes that share domains with RFX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFX3_HUMAN, P48380
    Function: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas
    development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during
    embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile
    cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in
    ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By
    similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during
    endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates
    transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of
    target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in
    neuronal cells

         Genatlas biochemistry entry for RFX3:
    transactivating DNA binding regulator 3,involved in MHC class II expression,binding the MHC promoter box X

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8600444
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8600444
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS8289803
    GO:0005515protein binding IPI--
    GO:0044212transcription regulatory region DNA binding IDA--
         
    Find genes that share ontologies with RFX3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RFX3:
     Increased S DNA content 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rfx3):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  normal 

    Find genes that share phenotypes with RFX3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RFX3: Rfx3tm2.1Wrth Rfx3tm1.1Wrth

       genOway: Develop your customized and physiologically relevant rodent model for RFX3

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CGGTTGCCATGGCAAC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RFX3:
    hsa-mir-342-3p (MIRT043701), hsa-mir-128-3p (MIRT021982), hsa-mir-615-3p (MIRT039992), hsa-mir-335-5p (MIRT017663), hsa-mir-148b-3p (MIRT019371)

    Block miRNA regulation of human, mouse, rat RFX3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RFX3:
    hsa-miR-519c-3p hsa-miR-519a hsa-miR-132 hsa-miR-519b-3p hsa-miR-1248 hsa-miR-212 hsa-miR-3145-3p hsa-miR-660
    SwitchGear 3'UTR luciferase reporter plasmidRFX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RFX3
    Predesigned siRNA for gene silencing in human, mouse, rat RFX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RFX3

    Clone
    Products:
         
    OriGene clones in human, mouse for RFX3 (see all 12)
    OriGene ORF clones in mouse, rat for RFX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFX3 (NM_134428)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RFX3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RFX3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RFX3_HUMAN, P48380: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus IC12411430
    GO:0005667transcription factor complex IC--

    Find genes that share ontologies with RFX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFX3
    Interactions:

        GeneGlobe Interaction Network for RFX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RFX3 (P483803 ENSP000003714344) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RFX4Q33E943, ENSP000003765854I2D: score=2 STRING: ENSP00000376585
    BIN1O004993, ENSP000003167794I2D: score=1 STRING: ENSP00000316779
    RFX1P226703, ENSP000002543254I2D: score=1 STRING: ENSP00000254325
    TRAF2Q129333, ENSP000002476684I2D: score=4 STRING: ENSP00000247668
    CREB1P162203, ENSP000003876994I2D: score=1 STRING: ENSP00000387699
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ISS--
    GO:0006366transcription from RNA polymerase II promoter TAS8289803
    GO:0007368determination of left/right symmetry ----
    GO:0031018endocrine pancreas development ISS--

    Find genes that share ontologies with RFX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFX3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RFX3 gene (4 alternative transcripts): 
    NM_001282116.1  NM_001282117.1  NM_002919.3  NM_134428.2  

    Unigene Cluster for RFX3:

    Regulatory factor X, 3 (influences HLA class II expression)
    Hs.136829  [show with all ESTs]
    Unigene Representative Sequence: NM_002919
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382004(uc003zhr.3 uc010mhd.3) ENST00000358730(uc003zht.1)
    ENST00000449234 ENST00000458034 ENST00000457373 ENST00000451859 ENST00000442560
    ENST00000420720 ENST00000449190 ENST00000381984 ENST00000302303(uc003zhs.1 uc010mhe.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RFX3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RFX3:
    hsa-miR-519c-3p hsa-miR-519a hsa-miR-132 hsa-miR-519b-3p hsa-miR-1248 hsa-miR-212 hsa-miR-3145-3p hsa-miR-660
    SwitchGear 3'UTR luciferase reporter plasmidRFX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RFX3
    Predesigned siRNA for gene silencing in human, mouse, rat RFX3
    Clone
    Products:
         
    OriGene clones in human, mouse for RFX3 (see all 12)
    OriGene ORF clones in mouse, rat for RFX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFX3 (NM_134428)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RFX3
    OriGene qSTAR qPCR primer pairs in human, mouse for RFX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFX3
      QuantiTect SYBR Green Assays in human, mouse, rat RFX3
      QuantiFast Probe-based Assays in human, mouse, rat RFX3

    Additional mRNA sequence: 

    AK289540.1 AK310956.1 BC022191.2 BC067778.1 X76092.1 

    11 DOTS entries:

    DT.405956  DT.441382  DT.121155249  DT.97805153  DT.95258766  DT.100717152  DT.75151345  DT.91735037 
    DT.121155239  DT.429875  DT.92418869 

    Selected AceView cDNA sequences (see all 52):

    BG192311 NM_134428 AI811824 BG196912 AA400681 NM_002919 BC022191 N46131 
    BQ721202 AI017287 BG717398 AI082685 BG196913 BU630533 X76092 AW440804 
    BU170404 AI203838 BM543944 AW027236 AA400596 H97909 BX350179 AW152407 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RFX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RFX3 Expression
    About this image


    RFX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
    RFX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.136829
        Custom PCR Arrays for RFX3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RFX3
    OriGene qSTAR qPCR primer pairs in human, mouse for RFX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFX3
    QuantiTect SYBR Green Assays in human, mouse, rat RFX3
    QuantiFast Probe-based Assays in human, mouse, rat RFX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RFX3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfx31 , 5 regulatory factor X, 3 (influences HLA class II expression)1, 5 92.48(n)1
    98.93(a)1
      19 (22.36 cM)5
    197261  NM_001166414.11  NP_001159886.11 
     277664415 
    chicken
    (Gallus gallus)
    Aves RFX31 regulatory factor X, 3 (influences HLA class II expression) 88.87(n)
    96.4(a)
      427351  XM_004949059.1  XP_004949116.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFX36
    regulatory factor X, 3 (influences HLA class II ex...
    96(a)
    1 ↔ 1
    2(51368864-51523468)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rfx31 regulatory factor X, 3 (influences HLA class II expression) 84.4(n)
    93.45(a)
      779608  NM_001276691.1  NP_001263620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rfx31 regulatory factor X, 3 (influences HLA class II expression) 69.68(n)
    76.01(a)
      570989  NM_001080048.1  NP_001073517.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rfx1 , 3 RNA polymerase II transcription factor3
    Rfx1
    55(a)3
    52.74(n)1
    52.63(a)1
      412661  NM_001260093.21  NP_001247022.21 
    worm
    (Caenorhabditis elegans)
    Secernentea daf-191 daf-19 51.29(n)
    43.4(a)
      174577  NM_001267307.1  NP_001254236.1 


    ENSEMBL Gene Tree for RFX3 (if available)
    TreeFam Gene Tree for RFX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RFX3 gene
    RFX62  RFX12  RFX82  RFX42  RFX22  
    3 SIMAP similar genes for RFX3 using alignment to 9 protein entries:     RFX3_HUMAN (see all proteins):
    RFX1    RFX2    RFX4

    Find genes that share paralogs with RFX3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RFX3 (see all 6925)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669520891,2
    C,F--3187095(-) CTTGT-/CTTGCTT
    GC
    /T/TTGC
    TTGCT
    2 -- int1 cds12NA 4
    rs1137406711,2
    F--3224295(+) GGAATG/TGGTAT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs8322971,2
    C,F,A,H--3224443(+) GCTCAA/TTTTTT 1 -- ds5001 trp328Minor allele frequency- T:0.18NA EA NS WA CSA 2742
    rs5748771,2
    C,F,A,H--3224519(+) TCTCCG/ATACTC 1 -- ds5001 ese332Minor allele frequency- A:0.12NS EA NA WA CSA 2240
    rs1909978471,2
    --3224622(+) CTCCAA/GTGTAA 1 -- ds50010--------
    rs1385109421,2
    --3224630(+) TAAATC/TAAAAA 1 -- ds50010--------
    rs1821476091,2
    --3224707(+) CAAGAC/TTAACA 1 -- ut310--------
    rs176585251,2
    C,F,H--3224828(+) AAGGGA/CAAAAA 1 -- ut31 trp312Minor allele frequency- C:0.02NA NS EA 1098
    rs1861172161,2
    --3224865(+) TTTACA/GTTAAA 1 -- ut310--------
    rs1995954131,2
    --3224995(+) GCCCAA/GTATCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RFX3 (3218297 - 3468297 bp, first 250kb of RFX3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RFX3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659402CNV Deletion23128226
    esv2477708CNV Deletion19546169
    nsv416089CNV Insertion16902084
    nsv415859CNV Insertion16902084
    esv1255308CNV Insertion17803354
    nsv892091CNV Loss21882294
    nsv892090CNV Loss21882294
    nsv466091CNV Loss19166990
    nsv522711CNV Gain19592680
    nsv892086CNV Gain21882294

    Human Gene Mutation Database (HGMD): RFX3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RFX3
    DNA2.0 Custom Variant and Variant Library Synthesis for RFX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601337    OMIM disorders: --

    2 diseases for RFX3:    
    About MalaCards
    chordoid glioma    pineoblastoma

    2 diseases from the University of Copenhagen DISEASES database for RFX3:
    Chordoid glioma     Pineoblastoma

    Find genes that share disorders with RFX3           About GenesLikeMe

    Genetic Association Database (GAD): RFX3
    Human Genome Epidemiology (HuGE) Navigator: RFX3 (1 document)

    Export disorders for RFX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RFX3 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with RFX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. (PubMed id 8289803)1, 2, 3 Reith W.... Mach B. (Mol. Cell. Biol. 1994)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. (PubMed id 12411430)1, 2 Nakayama A.... Takahashi M. (J. Biol. Chem. 2003)
    6. Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA- binding protein that cooperates with other human RFX members. (PubMed id 11682486)1, 9 Morotomi-Yano K.... Miki Y. (J. Biol. Chem. 2002)
    7. RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium. (PubMed id 23822649)1 Didon L....Crystal R.G. (Respir. Res. 2013)
    8. Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. (PubMed id 24058526)1 Bhatnagar P....Arking D.E. (PLoS ONE 2013)
    9. Ciliogenic RFX transcription factors regulate FGF1 gene promoter. (PubMed id 22415835)1 Hsu Y.C....Chiu I.M. (J. Cell. Biochem. 2012)
    10. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. (PubMed id 21532573)1 Engelen E....Poot R.A. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5991 HGNC: 9984 AceView: RFX3 Ensembl:ENSG00000080298 euGenes: HUgn5991
    ECgene: RFX3 H-InvDB: RFX3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RFX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RFX3 gene:
    Search GeneIP for patents involving RFX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RFX3   OriGene RNAi products in human, mouse, rat for RFX3  
     OriGene qPCR primer pairs and template standards for RFX3   OriGene Protein Over-expression Lysate for RFX3  
     OriGene MassSpec for RFX3   OriGene clones in human, mouse for RFX3  
     OriGene qSTAR qPCR primer pairs in human, mouse for RFX3   OriGene Purified Protein for RFX3  
     OriGene ORF clones in mouse, rat for RFX3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RFX3   OriGene Custom Protein Services for RFX3  

     
     
     Block miRNA regulation of human, mouse, rat RFX3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RFX3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFX3 Predesigned siRNA for gene silencing in human, mouse, rat RFX3
     QuantiFast Probe-based Assays in human, mouse, rat RFX3 QuantiTect SYBR Green Assays in human, mouse, rat RFX3
     Custom PCR Arrays for RFX3 Search Chromatin IP Primers for RFX3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFX3  GeneGlobe Interaction Network for RFX3
     Regulatory tfbs in RFX3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RFX3 GenScript cDNA clones with any tag delivered in your preferred vector for RFX3
     GenScript Custom Assay Services for RFX3 GenScript Custom overexpressing Cell Line Services for RFX3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RFX3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RFX3 antibodies
     RFX3 proteins
     RFX3 lysates
     Antibodies for RFX3
     See all of Abcam's Antibodies, Kits and Proteins for RFX3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RFX3
     Antibodies for RFX3
     ELISAs for RFX3
     CLIAs for RFX3



     Browse ESI BIO Cell Lines and PureStem Progenitors for RFX3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX3
     SwitchGear 3'UTR luciferase reporter plasmids for RFX3
     SwitchGear Promoter luciferase reporter plasmids for RFX3
     ThermoFisher Antibodies for RFX3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX3
     Browse compounds at ApexBio
     Search Addgene for plasmids for RFX3
      Search eBioscience for proteins for RFX3
      Search eBioscience for elisas for RFX3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RFX3
     antibodies-online antibodies for RFX3 (24 products)
     antibodies-online kits for RFX3 (4 products)
     antibodies-online peptides for RFX3
     antibodies-online proteins for RFX3 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RFX3 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4