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RFX2 Gene

protein-coding   GIFtS: 59
GCID: GC19M005944

Regulatory Factor X, 2 (Influences HLA Class II Expression)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulatory Factor X, 2 (Influences HLA Class II Expression)1 2
DNA Binding Protein RFX21 2
HLA Class II Regulatory Factor RFX21 2
Trans-Acting Regulatory Factor 21 2
Regulatory Factor X 22 3
DNA-Binding Protein RFX22

External Ids:    HGNC: 99831   Entrez Gene: 59902   Ensembl: ENSG000000879037   OMIM: 1427655   UniProtKB: P483783   

Export aliases for RFX2 gene to outside databases

Previous GC identifers: GC19M006085 GC19M005933 GC19M005752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RFX2 Gene:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a
highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to
regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a
heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5
receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and
both variants utilize alternative polyadenylation sites. (provided by RefSeq, Jul 2008)

GeneCards Summary for RFX2 Gene:
RFX2 (regulatory factor X, 2 (influences HLA class II expression)) is a protein-coding gene. Diseases associated with RFX2 include candidiasis, and breast and colorectal cancer. An important paralog of this gene is RFX6.

Gene Wiki entry for RFX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the RFX2 gene promoter:
         AhR   E2F-1   E2F   p300   MIF-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFX2 promoter sequence
   Search Chromatin IP Primers for RFX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

RFX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFX2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005944:  view genomic region     (about GC identifiers)

Start:
5,993,175 bp from pter      End:
6,199,583 bp from pter
Size:
206,409 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RFX2_HUMAN, P48378 (See protein sequence)
Recommended Name: DNA-binding protein RFX2  
Size: 723 amino acids; 79987 Da
Sequence caution: Sequence=BAG51286.1; Type=Erroneous initiation;
Secondary accessions: A8K581 B3KNC4 Q6IQ44 Q8SNA2
Alternative splicing: 2 isoforms:  P48378-1   P48378-2   

Explore the universe of human proteins at neXtProt for RFX2: NX_P48378

Explore proteomics data for RFX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RFX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000626.2  NP_602309.1  

    ENSEMBL proteins: 
     ENSP00000306335   ENSP00000352076   ENSP00000467166   ENSP00000466028   ENSP00000466177  
     ENSP00000467736   ENSP00000465122   ENSP00000467979   ENSP00000468036   ENSP00000464826  
     ENSP00000466890   ENSP00000468561   ENSP00000465135  

    RFX2 Human Recombinant Protein Products:

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    Novus Biologicals RFX2 Proteins
    Novus Biologicals RFX2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RFX2

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    LSBio Antibodies in human, mouse, rat for RFX2

    RFX2 Assay Products:

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    Cloud-Clone Corp. CLIAs for RFX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003150 DNA-bd_RFX
     IPR007668 RFX1_trans_act

    Graphical View of Domain Structure for InterPro Entry P48378

    ProtoNet protein and cluster: P48378

    2 Blocks protein domains:
    IPB003150 DNA-binding RFX
    IPB007668 RFX1 transcription activation region


    UniProtKB/Swiss-Prot: RFX2_HUMAN, P48378
    Similarity: Belongs to the RFX family
    Similarity: Contains 1 RFX-type winged-helix DNA-binding domain


    RFX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RFX2:
    transactivating DNA binding regulator 2,involved in MHC class II expression,binding the MHC promoter box X

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    RFX2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RFX2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFX2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GTTGCCATGGCAACM 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RFX2:
    hsa-mir-335-5p (MIRT018999), hsa-mir-124-3p (MIRT023118)

    Block miRNA regulation of human, mouse, rat RFX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RFX2 (see all 13):
    hsa-miR-30c hsa-miR-1237 hsa-miR-624* hsa-miR-548o hsa-miR-30d hsa-miR-3122 hsa-miR-30a hsa-miR-3913-5p
    SwitchGear 3'UTR luciferase reporter plasmidRFX2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RFX2
    Predesigned siRNA for gene silencing in human, mouse, rat RFX2

    Gene Editing
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    OriGene clones in human, mouse for RFX2 (see all 12)
    OriGene ORF clones in mouse, rat for RFX2
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    GenScript: all cDNA clones in your preferred vector (see all 2): RFX2 (NM_000635)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RFX2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RFX2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFX2_HUMAN, P48378: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    RFX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFX2
    Interactions:

        GeneGlobe Interaction Network for RFX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RFX2 (P483782, 3 ENSP000003063354) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    ENSG00000235068Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    RFX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RFX2 gene (2 alternative transcripts): 
    NM_000635.3  NM_134433.2  

    Unigene Cluster for RFX2:

    Regulatory factor X, 2 (influences HLA class II expression)
    Hs.465709  [show with all ESTs]
    Unigene Representative Sequence: NM_000635
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000303657(uc002meb.3) ENST00000359161(uc002mec.3 uc010xiy.1)
    ENST00000592546 ENST00000590778 ENST00000589340 ENST00000589742 ENST00000588021
    ENST00000592337 ENST00000586806 ENST00000587321 ENST00000586302 ENST00000592172
    ENST00000586940 ENST00000592473 ENST00000592883 ENST00000593241 ENST00000592281
    ENST00000587181
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RFX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RFX2 (see all 13):
    hsa-miR-30c hsa-miR-1237 hsa-miR-624* hsa-miR-548o hsa-miR-30d hsa-miR-3122 hsa-miR-30a hsa-miR-3913-5p
    SwitchGear 3'UTR luciferase reporter plasmidRFX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RFX2
    Predesigned siRNA for gene silencing in human, mouse, rat RFX2
    Clone
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    OriGene clones in human, mouse for RFX2 (see all 12)
    OriGene ORF clones in mouse, rat for RFX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFX2 (NM_000635)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RFX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFX2
      QuantiTect SYBR Green Assays in human, mouse, rat RFX2
      QuantiFast Probe-based Assays in human, mouse, rat RFX2

    Additional mRNA sequence: 

    AK024288.1 AK093575.1 AK093977.1 AK291196.1 AK302661.1 AK303321.1 BC028579.1 BC071571.1 
    BX648130.1 X76091.1 

    13 DOTS entries:

    DT.111694  DT.91697137  DT.442334  DT.91645373  DT.121422704  DT.121422652  DT.91721288  DT.91975372 
    DT.95153960  DT.99965452  DT.95273193  DT.121422600  DT.75133376 

    Selected AceView cDNA sequences (see all 107):

    BG012181 CR601447 BU500445 BC028579 BX089655 BE858092 BX648130 BE673216 
    BE254993 BM833701 CB306494 BI010605 AI863426 BM811287 AW136133 NM_000635 
    AI638804 BE242078 BI829093 AK024288 BU556952 NM_134433 AI306397 X76091 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RFX2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                    -     -                                   -     -                                                     -                                 
    SP2:                                                              -     -                                                     -                                 
    SP3:                                                              -     -     -     -                                         -                                 
    SP4:                                                                                                        -     -     -     -                                 
    SP5:                    -     -                                                                                                                                 

    ExUns: 19 ^ 20 ^ 21a · 21b · 21c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for RFX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RFX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACACGTA
    RFX2 Expression
    About this image


    RFX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Midbrain tegmentum
    RFX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465709
        Custom PCR Arrays for RFX2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RFX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RFX2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfx21 , 5 regulatory factor X, 2 (influences HLA class II expression)1, 5 83.59(n)1
    87.87(a)1
      17 (29.50 cM)5
    197251  NM_027787.11  NP_082063.11 
     567758975 
    chicken
    (Gallus gallus)
    Aves RFX21 regulatory factor X, 2 (influences HLA class II expression) 79.83(n)
    84.7(a)
      420092  XM_004948744.1  XP_004948801.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.17712 Xenopus laevis transcribed sequence with moderate similarity more 75.34(n)    BU909831.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570837672   -- 79.97(n)   321029  57083767 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rfx3 RNA polymerase II transcription factor 54(a)     --


    ENSEMBL Gene Tree for RFX2 (if available)
    TreeFam Gene Tree for RFX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RFX2 gene
    RFX62  RFX12  RFX32  RFX82  RFX42  
    5 SIMAP similar genes for RFX2 using alignment to 12 protein entries:     RFX2_HUMAN (see all proteins):
    RFX3    RFX7    RFX1    RFX8    RFX4

    RFX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RFX2 (see all 1796)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365314
    A breast cancer sample4--see VAR_0365312 E K mis40--------
    VAR_0365304
    A breast cancer sample4--see VAR_0365302 A G mis40--------
    rs1850518801,2
    --6020894(+) CAGGAC/TAGCAC 2 -- int10--------
    rs589057991,2
    F--6020933(+) CCTTTT/AAAGGA 2 -- int11Minor allele frequency- A:0.03WA 118
    rs789544371,2
    F--6020950(+) ATCCCG/AAAATG 2 -- int11Minor allele frequency- A:0.02EA 120
    rs1871801681,2
    C--6021138(+) CTGACA/GCTGGC 2 -- int10--------
    rs1162083711,2
    C,F--6021190(+) AGCTCG/TGGCAG 2 -- int11Minor allele frequency- T:0.08WA 118
    rs783786201,2
    C,F--6021206(+) CCAACC/TGTCCA 2 -- int11Minor allele frequency- T:0.07WA 118
    rs1916399241,2
    --6021280(+) TTTACA/GAGAGC 2 -- int10--------
    rs1171760291,2
    C,F--6021305(+) GCCTTG/ATTTAG 2 -- int11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for RFX2 (5993175 - 6199583 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RFX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718058CNV Deletion23290073
    esv2718057CNV Deletion23290073
    nsv910909CNV Loss21882294
    nsv910907CNV Loss21882294
    nsv910908CNV Loss21882294

    Human Gene Mutation Database (HGMD): RFX2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142765    OMIM disorders: --

    7 diseases for RFX2:    
    About MalaCards
    candidiasis    breast and colorectal cancer    bipolar disorder    hepatitis b
    schizophrenia    hepatitis    colorectal cancer


    RFX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RFX2
    Human Genome Epidemiology (HuGE) Navigator: RFX2 (4 documents)

    Export disorders for RFX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFX2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RFX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19. (PubMed id 1505960)1, 3, 9 Pugliatti L....Mach B. (Genomics 1992)
    2. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PubMed id 20889312)1, 4 Wang K.S....Aragam N. (Schizophr. Res. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. (PubMed id 8289803)1, 2 Reith W.... Mach B. (Mol. Cell. Biol. 1994)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Ciliogenic RFX transcription factors regulate FGF1 gene promoter. (PubMed id 22415835)1 Hsu Y.C....Chiu I.M. (J. Cell. Biochem. 2012)
    8. Transcriptional regulation of the AlstrAPm syndrome gene ALMS1 by members of the RFX family and Sp1. (PubMed id 20381594)1 Purvis T.L....Wilson D.I. (Gene 2010)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5990 HGNC: 9983 AceView: RFX2 Ensembl:ENSG00000087903 euGenes: HUgn5990
    ECgene: RFX2 H-InvDB: RFX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RFX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RFX2 gene:
    Search GeneIP for patents involving RFX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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