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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFX1 Gene

protein-coding   GIFtS: 55
GCID: GC19M014072

regulatory factor X, 1 (influences HLA class II expression)

 Explore 17 diseases affiliated with
RFX1 via our new
 Human Malady Compendium 
Biological research products
for RFX1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Regulatory Factor X, 1 (Influences HLA Class II Expression)1 2     RFX2 3
EF-C1 3     EFC2
Enhancer Factor C2 3     MHC Class II Regulatory Factor RFX2
Regulatory Factor X 12 3     MHC Class II Regulatory Factor RFX12
Transcription Factor RFX12 3     Trans-Acting Regulatory Factor 12

External Ids:    HGNC: 99821   Entrez Gene: 59892   Ensembl: ENSG000001320057   OMIM: 6000065   UniProtKB: P226703   

Export aliases for RFX1 gene to outside databases

Previous GC identifers: GC19M014429 GC19M013917 GC19M013933 GC19M013643


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RFX1:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a
highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to
regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a
heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II
genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression
of hepatitis B virus genes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RFX1_HUMAN, P22670
Function: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes.
Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream
element (alpha) of the RPL30 promoter

Gene Wiki entry for RFX1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFX1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CBF-C   E2F-1   E2F   CBF-A   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RFX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

RFX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFX1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014072:  view genomic region     (about GC identifiers)

Start:
14,072,342 bp from pter      End:
14,117,851 bp from pter
Size:
45,510 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RFX1_HUMAN, P22670 (See protein sequence)
Recommended Name: MHC class II regulatory factor RFX1  
Size: 979 amino acids; 104758 Da
Subunit: Binds DNA as a homodimer
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for RFX1:
1DP7 (3D)    

Explore the universe of human proteins at neXtProt for RFX1: NX_P22670

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22670

  • RFX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002909.4  
    ENSEMBL proteins: 
     ENSP00000254325   ENSP00000464960  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RFX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    RFX1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RFX1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RFX1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR003150 DNA-bd_RFX
     IPR007668 RFX1_trans_act

    Graphical View of Domain Structure for InterPro Entry P22670

    ProtoNet protein and cluster: P22670

    2 Blocks protein families:
    IPB003150 DNA-binding RFX
    IPB007668 RFX1 transcription activation region


    UniProtKB/Swiss-Prot: RFX1_HUMAN, P22670
    Similarity: Belongs to the RFX family
    Similarity: Contains 1 RFX-type winged-helix DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RFX1_HUMAN, P22670
    Function: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes.
    Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream
    element (alpha) of the RPL30 promoter

         Genatlas biochemistry entry for RFX1:
    transactivating DNA binding regulator 1,involved in MHC class II expression,binding the MHC promoter box X

    10/622 SABiosciences Target genes for RFX1 (see all 622):
    A1BG ABHD2 ABHD3 ABLIM3 ABP1 ACACB ACO2 ACOT6 ACOX2 ACOX3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RFX1:
    hsa-mir-346 (MIRT004241), hsa-mir-197 (MIRT004209)

    OriGene 3'-UTR Clone: RFX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFX1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX1 (see all 45):
    hsa-miR-300 hsa-miR-513a-5p hsa-miR-1245 hsa-miR-200a hsa-miR-25 hsa-miR-3653 hsa-miR-570 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidRFX1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFX1 (see all 7)
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    OriGene siRNA: RFX1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS8289803
    GO:0005515protein binding IPI16289097


    RFX1 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rfx1):
     mortality/aging 

    RFX1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/544 Interacting proteins for RFX1 (P226702, 3 ENSP000002543254) via UniProtKB, MINT, STRING, and/or I2D (see all 544)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADD1P356112, 3, ENSP000002647584MINT-72730 MINT-72732 MINT-72731 I2D: score=2 STRING: ENSP00000264758
    SMAD9O151982, 3, ENSP000003691544MINT-62083 I2D: score=3 STRING: ENSP00000369154
    HDAC1Q135472, 3, ENSP000003626494MINT-7947479 I2D: score=2 STRING: ENSP00000362649
    TADA3O755282, 3MINT-63209 I2D: score=5 
    SMAD1Q157972, 3, ENSP000003057694MINT-61998 I2D: score=3 STRING: ENSP00000305769
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS1505960


    RFX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RFX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RFX1
    1 Novoseek chemical compound relationship for RFX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 9.54 4 10642512 (3), 19450544 (1)

    Search CenterWatch for drugs/clinical trials and news about RFX1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RFX1 gene: 
    NM_002918.4  

    Unigene Cluster for RFX1:

    Regulatory factor X, 1 (influences HLA class II expression)
    Hs.655215  [show with all ESTs]
    Unigene Representative Sequence: NM_002918
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254325(uc002mxv.3 uc010dzi.2) ENST00000588520 ENST00000589239
    ENST00000589937 ENST00000589760 ENST00000588885 ENST00000586913

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate RFX1 (see all 45):
    hsa-miR-300 hsa-miR-513a-5p hsa-miR-1245 hsa-miR-200a hsa-miR-25 hsa-miR-3653 hsa-miR-570 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidRFX1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFX1 (see all 7)
    OriGene shRNA RFP: RFX1
    OriGene siRNA: RFX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFX1
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFX1 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFX1
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFX1

    Additional cDNA sequence: 

    AK309824.1 BC049826.1 X58964.1 

    3 DOTS entries:

    DT.407374  DT.86836256  DT.40210849 

    24/88 AceView cDNA sequences (see all 88):

    BG397745 NM_002918 BF984656 AA614838 BM557928 BX096049 BG393282 X58964 
    BG479691 BC049826 H10048 AI804324 AW732893 BE043039 AI417358 BF111397 
    BE855550 AW206881 BE730647 AW452532 BU902710 AI637732 AI204295 BM998406 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RFX1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:                                                                                    
    SP2:                                                  -                                 
    SP3:              -     -           -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for RFX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTTATCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RFX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RFX1

    SOURCE GeneReport for Unigene cluster: Hs.655215
        SABiosciences Custom PCR Arrays for RFX1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RFX1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfx11 , 5 regulatory factor X, 1 (influences HLA class II expression)1, 5 87.84(n)1
    93.24(a)1
      8 (40.28 cM)5
    197241  NM_009055.41  NP_033081.31 
     840668365 
    lizard
    (Anolis carolinensis)
    Reptilia RFX16
    --
    82(a)
    1 ↔ 1
    2(76886971-76937315)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ066285.12   -- 74.43(n)    BJ066285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rfx1a1 regulatory factor X, 1a (influences HLA class II expression) 67.25(n)
    70.03(a)
      100038773  NM_001089553.1  NP_001083022.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rfx3 RNA polymerase II transcription factor 53(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea daf-196
    RFX-like transcription factor daf-19
    26(a)
    1 → many
    II(10157478-10169262)


    ENSEMBL Gene Tree for RFX1 (if available)
    TreeFam Gene Tree for RFX1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFX1 gene
    RFX62  RFX32  RFX82  RFX42  RFX22  
    2 SIMAP similar genes for RFX1 using alignment to 2 protein entries:     RFX1_HUMAN (see all proteins):
    RFX3    RFX2

    RFX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/827 NCBI SNPs in RFX1 are shown (see all 827    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81043731,2
    C,F,A,H,--14071863(+) CGGCCC/GCCTTC 2 -- ut31 int110Minor allele frequency- G:0.17NS EA WA NA CSA 543
    rs1125884531,2
    C,--14072100(+) ATTTGC/-CCCTT 2 -- ut31 int12Minor allele frequency- -:0.25CSA 4
    rs104104181,2
    C,F,H--14072144(+) GAGGTC/TGAATG 2 -- ut31 int18Minor allele frequency- T:0.01NS EA 1348
    rs1852726611,2
    --14072257(+) CTGAAC/TCTCAT 2 -- int1 spd10--------
    rs104143811,2
    C,--14072305(+) CCCCCA/GCCCCA 2 -- int11Minor allele frequency- G:0.00WA 2
    rs1140503401,2
    --14072446(+) CCACCG/AGGAGA 2 -- ut31 int11Minor allele frequency- A:0.01WA 118
    rs1387040321,2
    --14072505(+) AGCACG/TCGGAG 2 -- int1 ut310--------
    rs1489194511,2
    --14072538(+) ACAATA/GGGTCA 2 -- ut31 int10--------
    rs1150281041,2
    --14072649(+) AAACCC/GAACAA 2 -- int1 ut311Minor allele frequency- G:0.01WA 118
    rs1156493191,2
    F,--14072670(+) CCGCTC/TGGGCG 2 -- int1 ut311Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for RFX1 (14072342 - 14117851 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RFX1
         1 Indel: 58861

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFX1
    DNA2.0 Custom Variant and Variant Library Synthesis for RFX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RFX1 for disorders           About GeneDecksing

    OMIM gene information: 600006    OMIM disorders: --

    17 diseases for RFX1:    About MalaCards
    hepatitis b    mhc class ii deficiency    diffuse large b-cell lymphoma    bare lymphocyte syndrome
    hepatitis    b-cell lymphomas    severe combined immunodeficiency    sickle cell anemia
    combined immunodeficiency    vaccinia    anemia    immunodeficiency
    breast cancer    neuroblastoma    adenocarcinoma    leukemia
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RFX1:
    Severe combined immunodeficiency

    4 Novoseek disease relationships for RFX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bare lymphocyte syndrome 93.8 1 10586057 (1)
    immunodeficiency 39.3 2 8436816 (1), 8290561 (1)
    hepatitis b 9.41 2 20155784 (1), 8600444 (1)
    cancer 3.04 1 15788405 (1)

    Genatlas disease: RFX1
    immunodeficiency,severe combined with defective expression of MHC class II gene

    Human Genome Epidemiology (HuGE) Navigator: RFX1 (1 document)

    Export disorders for RFX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFX1 gene, integrated from 9 sources (see all 129):
    (articles sorted by number of sources associating them with RFX1)
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    1. MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. (PubMed id 2253877)1, 2, 9 Reith W.... Mach B. (1990)
    2. The genes for MHC class II regulatory factors RFX1 an d RFX2 are located on the short arm of chromosome 19. (PubMed id 1505960)1, 3, 9 Pugliatti L....Mach B. (1992)
    3. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. (PubMed id 8289803)1, 3, 9 Reith W.... Mach B. (1994)
    4. Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. (PubMed id 10706293)1, 2, 9 Gajiwala K.S....Burley S.K. (2000)
    5. The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. (PubMed id 1508204)1, 2, 9 Sanchez-Herrero C.... Mach B. (1992)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer. (PubMed id 8413236)1, 2 Siegrist C.A....Reith W. (1993)
    8. Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element. (PubMed id 8224874)1, 2 Safrany G. and Perry R.P. (1993)
    9. RFX1 mediates the serum-induced immediate early response of Id2 gene expression. (PubMed id 17630394)1, 9 Wang K.R....Yokota Y. (2007)
    10. Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism. (PubMed id 11358531)1, 9 Katan-Khaykovich Y. and Shaul Y. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5989 HGNC: 9982 AceView: RFX1 Ensembl:ENSG00000132005 euGenes: HUgn5989
    ECgene: RFX1 H-InvDB: RFX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RFX1 gene:
    Search GeneIP for patents involving RFX1

    GeneCards and IP:
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