Aliases for RFX1 Gene
External Ids for RFX1 Gene
Previous GeneCards Identifiers for RFX1 Gene
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for RFX1 Gene
RFX1 (Regulatory Factor X, 1 (Influences HLA Class II Expression)) is a Protein Coding gene. Diseases associated with RFX1 include bare lymphocyte syndrome, type ii, complementation group c and hepatitis b. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is RFX3.
UniProtKB/Swiss-Prot for RFX1 Gene
Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter