Aliases for RFWD3 Gene
External Ids for RFWD3 Gene
Previous GeneCards Identifiers for RFWD3 Gene
GeneCards Summary for RFWD3 Gene
RFWD3 (Ring Finger And WD Repeat Domain 3) is a Protein Coding gene. GO annotations related to this gene include ligase activity and p53 binding.
UniProtKB/Swiss-Prot for RFWD3 Gene
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.