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RFWD3 Gene

protein-coding   GIFtS: 53
GCID: GC16M074656

Ring Finger And WD Repeat Domain 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger And WD Repeat Domain 31 2
RNF2012 3
RING Finger And WD Repeat Domain-Containing Protein 32 3
RING Finger Protein 2012 3
E3 Ubiquitin-Protein Ligase RFWD32
EC 6.3.2.-3

External Ids:    HGNC: 255391   Entrez Gene: 551592   Ensembl: ENSG000001684117   OMIM: 6141515   UniProtKB: Q6PCD53   

Export aliases for RFWD3 gene to outside databases

Previous GC identifers: GC16M073214 GC16M060404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RFWD3 Gene:
RFWD3 (ring finger and WD repeat domain 3) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and MDM2/MDM4 family protein binding.

UniProtKB/Swiss-Prot: RFWD3_HUMAN, Q6PCD5
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA
damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage
checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted
to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination,
possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in
RPA-mediated DNA damage signaling and repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RFWD3 gene promoter:
         NF-1   AML1a   SRF (504 AA)   Olf-1   GATA-1   GATA-6   Nkx6-1   NF-Y   Hlf   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFWD3 promoter sequence
   Search Chromatin IP Primers for RFWD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFWD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

RFWD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFWD3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M074656:  view genomic region     (about GC identifiers)

Start:
74,655,292 bp from pter      End:
74,700,779 bp from pter
Size:
45,488 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RFWD3_HUMAN, Q6PCD5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RFWD3  
Size: 774 amino acids; 85094 Da
Subunit: Interacts with MDM2 and p53/TP53. Binds to the RPA complex via direct interaction with RPA2
Developmental stage: Up-regulated in the S-G2 phase
Sequence caution: Sequence=BAA91662.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAF83889.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG38132.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K585 B2RE35 D3DUJ8 Q5XKR3 Q9H9Q3 Q9NVT4

Explore the universe of human proteins at neXtProt for RFWD3: NX_Q6PCD5

Explore proteomics data for RFWD3 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-46 and Ser-63 upon DNA damage by ATM or ATR. ATM phosphorylation occurs at early times upon
    DNA damage, while ATR is the major kinase at later times. Phosphorylation by ATM and ATR is required to stabilize
    p53/TP53. Part of the phosphorylation depends upon RPA2 presence1
  • Ubiquitination2 at Lys364, Lys370, Lys389, Lys402, Lys440, Lys498, Lys583, Lys658, Lys697, Lys766
  • Modification sites at PhosphoSitePlus

  • See RFWD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060594.3  
    ENSEMBL proteins: 
     ENSP00000354361   ENSP00000460049   ENSP00000459465   ENSP00000459899   ENSP00000459515  
     ENSP00000461285  

    RFWD3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RFWD3

     
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    antibodies-online proteins for RFWD3 (3 products) 

     
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    antibodies-online antibodies for RFWD3 (20 products) 

    RFWD3 Assay Products:

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    antibodies-online kits for RFWD3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6PCD5

    ProtoNet protein and cluster: Q6PCD5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RFWD3_HUMAN, Q6PCD5
    Domain: The coiled coil domain may be involved in RPA2-binding
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 3 WD repeats


    Find genes that share domains with RFWD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFWD3_HUMAN, Q6PCD5
    Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA
    damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage
    checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted
    to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination,
    possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in
    RPA-mediated DNA damage signaling and repair

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RFWD3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RFWD3:
     Decreased viability with cispl  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RFWD3

    miRNA
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    miRTarBase miRNAs that target RFWD3:
    hsa-mir-125b-5p (MIRT046102), hsa-mir-192-5p (MIRT026221), hsa-mir-124-3p (MIRT022290), hsa-mir-215-5p (MIRT024660), hsa-mir-340-5p (MIRT019540), hsa-mir-484 (MIRT041944), hsa-mir-339-5p (MIRT042746), hsa-let-7c-5p (MIRT051730)

    Block miRNA regulation of human, mouse, rat RFWD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RFWD3 (see all 26):
    hsa-miR-124* hsa-miR-142-3p hsa-miR-607 hsa-miR-539 hsa-miR-330-5p hsa-miR-2110 hsa-miR-371-5p hsa-miR-20b*
    SwitchGear 3'UTR luciferase reporter plasmidRFWD3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFWD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFWD3_HUMAN, Q6PCD5: Nucleus. Nucleus, PML body. Cytoplasm. Note=In undamaged cells, found both in the cytoplasm
    and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that
    caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the
    nucleus, to stalled replication forks or to sites of DNA repair. This recruitment depends upon RPA2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016605PML body IEA--

    Find genes that share ontologies with RFWD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: RFWD3_HUMAN, Q6PCD5
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFWD3
    Interactions:

        Search GeneGlobe Interaction Network for RFWD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RFWD3 (Q6PCD53 ENSP000003543614) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0010212response to ionizing radiation IDA--
    GO:0016567protein ubiquitination IDA--
    GO:0031571mitotic G1 DNA damage checkpoint IMP--

    Find genes that share ontologies with RFWD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFWD3

    2 HMDB Compounds for RFWD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RFWD3 gene: 
    NM_018124.3  

    Unigene Cluster for RFWD3:

    Ring finger and WD repeat domain 3
    Hs.567525  [show with all ESTs]
    Unigene Representative Sequence: NM_018124
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361070(uc010vmx.2 uc002fda.3 uc010cgq.3) ENST00000571750
    ENST00000575154 ENST00000575281 ENST00000572610 ENST00000572337 ENST00000571776
    ENST00000575397 ENST00000572990 ENST00000576652 ENST00000575113 ENST00000572840

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RFWD3 (see all 26):
    hsa-miR-124* hsa-miR-142-3p hsa-miR-607 hsa-miR-539 hsa-miR-330-5p hsa-miR-2110 hsa-miR-371-5p hsa-miR-20b*
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      QuantiFast Probe-based Assays in human, mouse, rat RFWD3

    Additional mRNA sequence: 

    AK001382.1 AK022673.1 AK291200.1 AK296727.1 AK315786.1 BC002574.2 BC059371.1 

    13 DOTS entries:

    DT.208381  DT.91975406  DT.101983212  DT.100018510  DT.97790418  DT.100713831  DT.120664034  DT.91747005 
    DT.120663993  DT.97806907  DT.95352376  DT.97808222  DT.120664046 

    Selected AceView cDNA sequences (see all 175):

    AW780284 BQ005320 BX641846 CR598867 CA431275 BM561564 BC002574 AI560910 
    BX955838 BQ677500 BQ215818 BE733156 BC059371 AA888009 CK905473 BM913008 
    AA232458 AU124886 CD516080 AA227251 AW673685 BM560852 BQ649632 BI063493 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RFWD3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
    SP1:                          -     -     -     -                             -                 -                             -                       -         
    SP2:                                                                                                                          -                                 
    SP3:                          -     -                                         -                                                                                 
    SP4:                          -                 -                                                                                                               
    SP5:                          -     -           -                                                                                                               

    ExUns: 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for RFWD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RFWD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACTCTGT
    RFWD3 Expression
    About this image


    RFWD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
    RFWD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFWD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567525
        Custom PCR Arrays for RFWD3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFWD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RFWD3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfwd31 , 5 ring finger and WD repeat domain 31, 5 76.7(n)1
    70.03(a)1
      8 (57.98 cM)5
    2347361  NM_146218.41  NP_666330.21 
     1112709445 
    chicken
    (Gallus gallus)
    Aves RFWD31 ring finger and WD repeat domain 3 67.27(n)
    63.59(a)
      415684  XM_414051.4  XP_414051.3 
    lizard
    (Anolis carolinensis)
    Reptilia RFWD36
    ring finger and WD repeat domain 3
    56(a)
    1 ↔ 1
    GL343840.1(181946-197256)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.296382 Xenopus laevis transcribed sequences 73.21(n)    BJ062741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570785572   -- 71.47(n)    57078557 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG130251 CG13025 41.08(n)
    30.45(a)
      39874  NM_001275042.1  NP_001261971.1 


    ENSEMBL Gene Tree for RFWD3 (if available)
    TreeFam Gene Tree for RFWD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RFWD3 (see all 1265)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360095911,2
    C--74654875(+) CAGTT-/AAAAAA 1 -- ds50012Minor allele frequency- A:0.25NA 4
    rs287114081,2
    C--74654888(+) AAAAAG/AAAAAA 1 -- ds50012Minor allele frequency- A:0.25NA 4
    rs48877801,2
    C,F--74654889(+) aaaaaG/Aaaaaa 1 -- ds50012Minor allele frequency- A:0.50NA WA 4
    rs1849407891,2
    --74654956(+) GCAGAG/TCACAA 1 -- ds50010--------
    rs1890106021,2
    --74655107(+) GAGGCA/GGAGTT 1 -- ds50010--------
    rs1403442811,2
    --74655127(+) CCAAGA/TTGGCG 1 -- ds50010--------
    rs48877811,2
    C,F--74655150(+) AGCTAG/CGGCTA 1 -- ds50017Minor allele frequency- C:0.21NA WA CSA EA 365
    rs784847551,2
    C,F--74655179(+) CAAAAA/CACAAA 1 -- ds50015Minor allele frequency- C:0.07NA WA EA 362
    rs1503630881,2
    --74655268(+) AAGTGA/GAAGAG 1 -- ds50010--------
    rs1382092521,2
    C--74655436(+) AGTTCA/GTTTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RFWD3 (74655292 - 74700779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RFWD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833279CNV Loss17160897
    nsv906906CNV Gain21882294
    nsv906905CNV Gain21882294
    esv275138CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RFWD3
    DNA2.0 Custom Variant and Variant Library Synthesis for RFWD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614151    OMIM disorders: --


    Find genes that share disorders with RFWD3           About GenesLikeMe

    Genetic Association Database (GAD): RFWD3
    Human Genome Epidemiology (HuGE) Navigator: RFWD3 (1 document)

    Export disorders for RFWD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFWD3 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RFWD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E3 ligase RFWD3 participates in replication checkpoint control. (PubMed id 21504906)1, 2, 3 Gong Z. and Chen J. (J. Biol. Chem. 2011)
    2. RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. (PubMed id 21558276)1, 2 Liu S.... Wang Y. (J. Biol. Chem. 2011)
    3. RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. (PubMed id 20173098)1, 2 Fu X.... Wang Y. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Meta-analysis identifies four new loci associated with testicular germ cell tumor. (PubMed id 23666239)1 Chung C.C....Nathanson K.L. (Nat. Genet. 2013)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55159 HGNC: 25539 AceView: FLJ10520 Ensembl:ENSG00000168411 euGenes: HUgn55159
    ECgene: RFWD3 H-InvDB: RFWD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RFWD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RFWD3 gene:
    Search GeneIP for patents involving RFWD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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