Aliases for RFWD2 Gene
External Ids for RFWD2 Gene
GeneCards Summary for RFWD2 Gene
RFWD2 (Ring Finger And WD Repeat Domain 2, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Direct p53 effectors. GO annotations related to this gene include ligase activity. An important paralog of this gene is RBBP4.
UniProtKB/Swiss-Prot for RFWD2 Gene
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation.