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Aliases for RFTN2 Gene

Aliases for RFTN2 Gene

  • Raftlin Family Member 2 2 3
  • Raft-Linking Protein 2 3 4
  • C2orf11 3 4
  • Chromosome 2 Open Reading Frame 11 2
  • Raftlin-2 3

External Ids for RFTN2 Gene

Previous HGNC Symbols for RFTN2 Gene

  • C2orf11

Previous GeneCards Identifiers for RFTN2 Gene

  • GC02M198144
  • GC02M198435
  • GC02M190287

Summaries for RFTN2 Gene

GeneCards Summary for RFTN2 Gene

RFTN2 (Raftlin Family Member 2) is a Protein Coding gene. An important paralog of this gene is RFTN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFTN2 Gene

Genomics for RFTN2 Gene

Regulatory Elements for RFTN2 Gene

Genomic Location for RFTN2 Gene

197,568,224 bp from pter
197,676,050 bp from pter
107,827 bases
Minus strand

Genomic View for RFTN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFTN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFTN2 Gene

Proteins for RFTN2 Gene

  • Protein details for RFTN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q14DH4
    • Q2TA69
    • Q53QE0
    • Q53SE1
    • Q96NM3

    Protein attributes for RFTN2 Gene

    501 amino acids
    Molecular mass:
    55922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RFTN2 Gene

Proteomics data for RFTN2 Gene at MOPED

Post-translational modifications for RFTN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFTN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFTN2 Gene

Domains for RFTN2 Gene

Protein Domains for RFTN2 Gene


Suggested Antigen Peptide Sequences for RFTN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q52LD8
  • Belongs to the raftlin family.
genes like me logo Genes that share domains with RFTN2: view

No data available for Gene Families for RFTN2 Gene

Function for RFTN2 Gene

Animal Model Products

miRNA for RFTN2 Gene

miRTarBase miRNAs that target RFTN2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RFTN2 Gene

Localization for RFTN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFTN2 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for RFTN2 Gene COMPARTMENTS Subcellular localization image for RFTN2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RFTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RFTN2: view

Pathways for RFTN2 Gene

SuperPathways for RFTN2 Gene

No Data Available

Interacting Proteins for RFTN2 Gene

Gene Ontology (GO) - Biological Process for RFTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033227 dsRNA transport IEA --
GO:0043330 response to exogenous dsRNA IEA --
genes like me logo Genes that share ontologies with RFTN2: view

No data available for Pathways by source for RFTN2 Gene

Transcripts for RFTN2 Gene

Unigene Clusters for RFTN2 Gene

Raftlin family member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFTN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFTN2 Gene

No ASD Table

Relevant External Links for RFTN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFTN2 Gene

mRNA expression in normal human tissues for RFTN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFTN2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RFTN2 Gene

SOURCE GeneReport for Unigene cluster for RFTN2 Gene Hs.591615

genes like me logo Genes that share expressions with RFTN2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RFTN2 Gene

Orthologs for RFTN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFTN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFTN2 35
  • 99.53 (n)
  • 99.4 (a)
RFTN2 36
  • 99 (a)
(Bos Taurus)
Mammalia RFTN2 36
  • 86 (a)
(Canis familiaris)
Mammalia RFTN2 35
  • 89.87 (n)
  • 86.92 (a)
RFTN2 36
  • 86 (a)
(Mus musculus)
Mammalia Rftn2 35
  • 80.6 (n)
  • 79.8 (a)
Rftn2 16
Rftn2 36
  • 80 (a)
(Monodelphis domestica)
Mammalia RFTN2 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia RFTN2 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Rftn2 35
  • 80.17 (n)
  • 79.03 (a)
(Gallus gallus)
Aves RFTN2 35
  • 74.49 (n)
  • 71.46 (a)
RFTN2 36
  • 69 (a)
(Anolis carolinensis)
Reptilia RFTN2 36
  • 64 (a)
(Danio rerio)
Actinopterygii rftn2 35
  • 54.16 (n)
  • 50.35 (a)
rftn2 36
  • 48 (a)
Species with no ortholog for RFTN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFTN2 Gene

Gene Tree for RFTN2 (if available)
Gene Tree for RFTN2 (if available)

Paralogs for RFTN2 Gene

Paralogs for RFTN2 Gene

Selected SIMAP similar genes for RFTN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RFTN2: view

Variants for RFTN2 Gene

Sequence variations from dbSNP and Humsavar for RFTN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs970551 -- 197,632,985(-) AAGGG(A/G)TAATA intron-variant
rs970552 -- 197,632,788(-) ATCCT(A/C)TACAT intron-variant
rs1023871 -- 197,646,977(-) ATGAC(C/T)TTAAA intron-variant
rs1023872 -- 197,646,922(-) ATTGG(A/G)GGTTT intron-variant
rs1023873 -- 197,646,920(-) TGGGG(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFTN2 Gene

Variant ID Type Subtype PubMed ID
nsv3098 CNV Insertion 18451855

Relevant External Links for RFTN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFTN2 Gene

Disorders for RFTN2 Gene

Relevant External Links for RFTN2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with RFTN2: view

No data available for UniProtKB/Swiss-Prot for RFTN2 Gene

Publications for RFTN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RFTN2 Gene

Sources for RFTN2 Gene

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