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Aliases for RFTN2 Gene

Aliases for RFTN2 Gene

  • Raftlin Family Member 2 2 3 5
  • Raft-Linking Protein 2 3 4
  • C2orf11 3 4
  • Chromosome 2 Open Reading Frame 11 2
  • Raftlin-2 3

External Ids for RFTN2 Gene

Previous HGNC Symbols for RFTN2 Gene

  • C2orf11

Previous GeneCards Identifiers for RFTN2 Gene

  • GC02M198144
  • GC02M198435
  • GC02M190287

Summaries for RFTN2 Gene

GeneCards Summary for RFTN2 Gene

RFTN2 (Raftlin Family Member 2) is a Protein Coding gene. An important paralog of this gene is RFTN1.

Additional gene information for RFTN2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFTN2 Gene

Genomics for RFTN2 Gene

Regulatory Elements for RFTN2 Gene

Enhancers for RFTN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H197627 1.4 FANTOM5 Ensembl ENCODE 9.8 +47.9 47870 1 PKNOX1 EBF1 RELA EED ATF7 RUNX3 IKZF2 CREM MAZ ZNF687 PLCL1 RFTN2 COQ10B GC02P197600
GH02H196798 1.2 ENCODE 10.1 +876.5 876464 1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 GTF3C3 SF3B1 NPM1P46 RFTN2 LOC100130452
GH02H197803 1 ENCODE 6.1 -128.8 -128819 2 PKNOX1 ARNT ARID4B SIN3A GLIS2 ZNF143 FOS ATF7 NFYC REST PLCL1 SF3B1 RFTN2 LOC105373828
GH02H197928 1 ENCODE 6.1 -253.4 -253436 0 PKNOX1 ATF1 ARNT TCF12 GATA2 ELK1 FOS ATF7 NCOA1 REST RFTN2 GC02M197892 GC02M197987
GH02H197847 1 FANTOM5 ENCODE dbSUPER 5.7 -172.3 -172332 2 RFX5 PLCL1 BOLL SF3B1 RFTN2 MOB4 GC02P197830 GC02M197883
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RFTN2 on UCSC Golden Path with GeneCards custom track

Promoters for RFTN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128458 1145 2601 PKNOX1 RNF2 ZNF512 ZNF384 PRDM1 TRIM28

Genomic Location for RFTN2 Gene

Chromosome:
2
Start:
197,568,224 bp from pter
End:
197,676,045 bp from pter
Size:
107,822 bases
Orientation:
Minus strand

Genomic View for RFTN2 Gene

Genes around RFTN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFTN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFTN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFTN2 Gene

Proteins for RFTN2 Gene

  • Protein details for RFTN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52LD8-RFTN2_HUMAN
    Recommended name:
    Raftlin-2
    Protein Accession:
    Q52LD8
    Secondary Accessions:
    • Q14DH4
    • Q2TA69
    • Q53QE0
    • Q53SE1
    • Q96NM3

    Protein attributes for RFTN2 Gene

    Size:
    501 amino acids
    Molecular mass:
    55922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RFTN2 Gene

Post-translational modifications for RFTN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFTN2 Gene

No data available for DME Specific Peptides for RFTN2 Gene

Domains & Families for RFTN2 Gene

Gene Families for RFTN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RFTN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RFTN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q52LD8

UniProtKB/Swiss-Prot:

RFTN2_HUMAN :
  • Belongs to the raftlin family.
Family:
  • Belongs to the raftlin family.
genes like me logo Genes that share domains with RFTN2: view

Function for RFTN2 Gene

Phenotypes From GWAS Catalog for RFTN2 Gene

genes like me logo Genes that share phenotypes with RFTN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RFTN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RFTN2 Gene

Localization for RFTN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFTN2 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFTN2 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RFTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0045121 membrane raft IBA --
genes like me logo Genes that share ontologies with RFTN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RFTN2 Gene

Pathways & Interactions for RFTN2 Gene

SuperPathways for RFTN2 Gene

No Data Available

Interacting Proteins for RFTN2 Gene

Selected Interacting proteins: Q52LD8-RFTN2_HUMAN for RFTN2 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for RFTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032596 protein transport into membrane raft IBA --
GO:0033227 dsRNA transport IEA --
GO:0043330 response to exogenous dsRNA IEA --
GO:0050851 antigen receptor-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with RFTN2: view

No data available for Pathways by source and SIGNOR curated interactions for RFTN2 Gene

Drugs & Compounds for RFTN2 Gene

No Compound Related Data Available

Transcripts for RFTN2 Gene

Unigene Clusters for RFTN2 Gene

Raftlin family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RFTN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RFTN2 Gene

No ASD Table

Relevant External Links for RFTN2 Gene

GeneLoc Exon Structure for
RFTN2
ECgene alternative splicing isoforms for
RFTN2

Expression for RFTN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RFTN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFTN2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.8).

Protein differential expression in normal tissues from HIPED for RFTN2 Gene

This gene is overexpressed in Frontal cortex (43.4), Fetal Brain (13.4), and Spinal cord (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RFTN2 Gene



Protein tissue co-expression partners for RFTN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RFTN2 Gene:

RFTN2

SOURCE GeneReport for Unigene cluster for RFTN2 Gene:

Hs.591615

Evidence on tissue expression from TISSUES for RFTN2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with RFTN2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFTN2 Gene

Orthologs for RFTN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFTN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFTN2 33 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia RFTN2 33 34
  • 89.87 (n)
cow
(Bos Taurus)
Mammalia RFTN2 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rftn2 33 16 34
  • 80.6 (n)
rat
(Rattus norvegicus)
Mammalia Rftn2 33
  • 80.17 (n)
oppossum
(Monodelphis domestica)
Mammalia RFTN2 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFTN2 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves RFTN2 33 34
  • 74.49 (n)
lizard
(Anolis carolinensis)
Reptilia RFTN2 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rftn2 33 34
  • 54.16 (n)
Species where no ortholog for RFTN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFTN2 Gene

ENSEMBL:
Gene Tree for RFTN2 (if available)
TreeFam:
Gene Tree for RFTN2 (if available)

Paralogs for RFTN2 Gene

Paralogs for RFTN2 Gene

(1) SIMAP similar genes for RFTN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RFTN2: view

Variants for RFTN2 Gene

Sequence variations from dbSNP and Humsavar for RFTN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000007782 -- 197,672,788(+) TCTAT(A/G)CTATG intron-variant
rs1000015357 -- 197,656,058(+) TACTC(A/G)TGGAG intron-variant
rs1000021693 -- 197,604,280(+) CTCAC(A/G)CATGT intron-variant
rs1000046082 -- 197,654,011(+) TGTCA(C/T)ACAAA intron-variant
rs1000060977 -- 197,660,715(+) CACCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFTN2 Gene

Variant ID Type Subtype PubMed ID
esv3593908 CNV loss 21293372
esv3593909 CNV loss 21293372
nsv1000017 CNV loss 25217958
nsv1014881 CNV gain 25217958
nsv1139742 CNV duplication 24896259
nsv3098 CNV insertion 18451855
nsv584156 CNV gain 21841781

Variation tolerance for RFTN2 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFTN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RFTN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFTN2 Gene

Disorders for RFTN2 Gene

Relevant External Links for RFTN2

Genetic Association Database (GAD)
RFTN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFTN2

No disorders were found for RFTN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFTN2 Gene

Publications for RFTN2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 60

Products for RFTN2 Gene

Sources for RFTN2 Gene

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