Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RFTN2 Gene

Aliases for RFTN2 Gene

  • Raftlin Family Member 2 2 3 5
  • Raft-Linking Protein 2 3 4
  • C2orf11 3 4
  • Chromosome 2 Open Reading Frame 11 2
  • Raftlin-2 3

External Ids for RFTN2 Gene

Previous HGNC Symbols for RFTN2 Gene

  • C2orf11

Previous GeneCards Identifiers for RFTN2 Gene

  • GC02M198144
  • GC02M198435
  • GC02M190287

Summaries for RFTN2 Gene

GeneCards Summary for RFTN2 Gene

RFTN2 (Raftlin Family Member 2) is a Protein Coding gene. An important paralog of this gene is RFTN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFTN2 Gene

Genomics for RFTN2 Gene

Regulatory Elements for RFTN2 Gene

Promoters for RFTN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RFTN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RFTN2 Gene

Chromosome:
2
Start:
197,568,224 bp from pter
End:
197,676,045 bp from pter
Size:
107,822 bases
Orientation:
Minus strand

Genomic View for RFTN2 Gene

Genes around RFTN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFTN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFTN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFTN2 Gene

Proteins for RFTN2 Gene

  • Protein details for RFTN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52LD8-RFTN2_HUMAN
    Recommended name:
    Raftlin-2
    Protein Accession:
    Q52LD8
    Secondary Accessions:
    • Q14DH4
    • Q2TA69
    • Q53QE0
    • Q53SE1
    • Q96NM3

    Protein attributes for RFTN2 Gene

    Size:
    501 amino acids
    Molecular mass:
    55922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RFTN2 Gene

Proteomics data for RFTN2 Gene at MOPED

Post-translational modifications for RFTN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFTN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFTN2 Gene

Domains & Families for RFTN2 Gene

Protein Domains for RFTN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RFTN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q52LD8

UniProtKB/Swiss-Prot:

RFTN2_HUMAN :
  • Belongs to the raftlin family.
Family:
  • Belongs to the raftlin family.
genes like me logo Genes that share domains with RFTN2: view

No data available for Gene Families for RFTN2 Gene

Function for RFTN2 Gene

genes like me logo Genes that share phenotypes with RFTN2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RFTN2 Gene

Localization for RFTN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFTN2 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFTN2 Gene COMPARTMENTS Subcellular localization image for RFTN2 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RFTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RFTN2: view

Pathways & Interactions for RFTN2 Gene

SuperPathways for RFTN2 Gene

No Data Available

Interacting Proteins for RFTN2 Gene

Gene Ontology (GO) - Biological Process for RFTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043330 response to exogenous dsRNA IEA --
GO:0050851 antigen receptor-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with RFTN2: view

No data available for Pathways by source and SIGNOR curated interactions for RFTN2 Gene

Drugs & Compounds for RFTN2 Gene

No Compound Related Data Available

Transcripts for RFTN2 Gene

Unigene Clusters for RFTN2 Gene

Raftlin family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFTN2 Gene

No ASD Table

Relevant External Links for RFTN2 Gene

GeneLoc Exon Structure for
RFTN2
ECgene alternative splicing isoforms for
RFTN2

Expression for RFTN2 Gene

mRNA expression in normal human tissues for RFTN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFTN2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.8).

Protein differential expression in normal tissues from HIPED for RFTN2 Gene

This gene is overexpressed in Frontal cortex (43.4), Fetal Brain (13.4), and Spinal cord (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RFTN2 Gene



SOURCE GeneReport for Unigene cluster for RFTN2 Gene Hs.591615

genes like me logo Genes that share expression patterns with RFTN2: view

Protein tissue co-expression partners for RFTN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RFTN2 Gene

Orthologs for RFTN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFTN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFTN2 35
  • 99.53 (n)
  • 99.4 (a)
RFTN2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RFTN2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFTN2 36
  • 86 (a)
OneToOne
RFTN2 35
  • 89.87 (n)
  • 86.92 (a)
mouse
(Mus musculus)
Mammalia Rftn2 16
Rftn2 36
  • 80 (a)
OneToOne
Rftn2 35
  • 80.6 (n)
  • 79.8 (a)
oppossum
(Monodelphis domestica)
Mammalia RFTN2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFTN2 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rftn2 35
  • 80.17 (n)
  • 79.03 (a)
chicken
(Gallus gallus)
Aves RFTN2 35
  • 74.49 (n)
  • 71.46 (a)
RFTN2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RFTN2 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rftn2 36
  • 48 (a)
OneToOne
rftn2 35
  • 54.16 (n)
  • 50.35 (a)
Species with no ortholog for RFTN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFTN2 Gene

ENSEMBL:
Gene Tree for RFTN2 (if available)
TreeFam:
Gene Tree for RFTN2 (if available)

Paralogs for RFTN2 Gene

Paralogs for RFTN2 Gene

(1) SIMAP similar genes for RFTN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RFTN2: view

Variants for RFTN2 Gene

Sequence variations from dbSNP and Humsavar for RFTN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs970551 -- 197,632,985(-) AAGGG(A/G)TAATA intron-variant
rs970552 -- 197,632,788(-) ATCCT(A/C)TACAT intron-variant
rs1455653 -- 197,613,596(-) CACAA(C/T)GATAG intron-variant
rs1993358 -- 197,614,049(-) AGTCT(A/G)TAGGT intron-variant
rs1598469 -- 197,650,934(-) gatgc(A/G)gacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFTN2 Gene

Variant ID Type Subtype PubMed ID
nsv3098 CNV Insertion 18451855

Variation tolerance for RFTN2 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFTN2 Gene

HapMap Linkage Disequilibrium report
RFTN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFTN2 Gene

Disorders for RFTN2 Gene

Relevant External Links for RFTN2

Genetic Association Database (GAD)
RFTN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFTN2

No disorders were found for RFTN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFTN2 Gene

Publications for RFTN2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for RFTN2 Gene

Sources for RFTN2 Gene

Back to Top

Content