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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RFTN2 Gene

protein-coding GIFtS: 39
GCID: GC02M198435

raftlin family member 2

(Previous name: chromosome 2 open reading frame 11 )
(Previous symbol: C2orf11)

Search for RFTN2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Raftlin Family Member 2¹ ²		FLJ30574¹
C2orf11¹ ² ³		Chromosome 2 Open Reading Frame 11¹
Raftlin-2¹ ²		Raftlin-2¹ ²
Raft-Linking Protein 2² ³

External Ids:	HGNC: 26402¹	Entrez Gene: 130132²	Ensembl: ENSG00000162944⁷	UniProtKB: Q52LD8³

Export aliases for RFTN2 gene to outside databases

Previous GC identifers: GC02M198144 GC02M190287

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RFTN2 gene promoter:
FOXF2 FOXD1 Nkx2-5 FOXL1 NF-AT NF-AT4 NF-AT2 FOXC1 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RFTN2 promoter sequence

Search SABiosciences Chromatin IP Primers for RFTN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFTN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1

RFTN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFTN2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M198435: view genomic region (about GC identifiers)

Start:	198,435,524 bp from pter	End:	198,540,769 bp from pter
Size:	105,246 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RFTN2_HUMAN, Q52LD8 (See protein sequence)

Recommended Name: Raftlin-2

Size: 501 amino acids; 55922 Da

Subcellular location: Cell membrane; Lipid-anchor (By similarity)

Secondary accessions: Q14DH4 Q2TA69 Q53QE0 Q53SE1 Q96NM3

Explore the universe of human proteins at neXtProt for RFTN2: NX_Q52LD8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q52LD8

RFTN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653230.2

ENSEMBL proteins:

ENSP00000295049 ENSP00000387459 ENSP00000398128

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--

RFTN2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q52LD8

UniProtKB/Swiss-Prot: RFTN2_HUMAN, Q52LD8

Similarity: Belongs to the raftlin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RFTN2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RFTN2 gene:

NM_144629.2

Unigene Cluster for RFTN2:

Raftlin family member 2

Hs.591615 [show with all ESTs]

Unigene Representative Sequence: BC111069

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295049(uc002uuo.4) ENST00000494346 ENST00000454447 ENST00000429081

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Additional cDNA sequence:

AK055136.1 AK090941.1 BC039690.1 BC093966.1 BC111069.1 BC113361.1 BX647618.1

3 DOTS entries:

DT.40203129 DT.40269976 DT.92419655

24/40 AceView cDNA sequences (see all 40):

BX108193 AI149843 BI490922 AV709198 AA382640 AV709477 AA448720 R82253

CK005093 AW592576 AI126475 H84568 BI769216 R82200 BI559742 BX647618

Z44694 AI206317 AV727504 BI772721 AV727858 BX451958 BI495218 AK090941

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RFTN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCAACCC

About this image

RFTN2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

White adipocyte-like cells (Differentiation of ...)

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RFTN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RFTN2

SOURCE GeneReport for Unigene cluster: Hs.591615

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RFTN2 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RFTN2¹	raftlin family member 2	74.56(n) 71.46(a)		424062 XM_421918.3 XP_421918.2
lizard (Anolis carolinensis)	Reptilia	RFTN2⁶	--	64(a)	1 ↔ 1	GL343436.1(602067-648101)
zebrafish (Danio rerio)	Actinopterygii	BC051615.1²	--	73.97(n)		BC051615.1

ENSEMBL Gene Tree for RFTN2 (if available)
TreeFam Gene Tree for RFTN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RFTN2 gene

RFTN1²

1 SIMAP similar gene for RFTN2 using alignment to 3 protein entries: RFTN2_HUMAN (see all proteins):

RFTN1

RFTN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190798899^1,2		--	198435040(+)	`ACTTCC/TGGATG`	1	--	int¹		0	--	--	--	--
rs141762098^1,2		--	198435087(+)	`ATTAAC/TGGAGA`	1	--	int¹		0	--	--	--	--
rs115689404^1,2	F,	--	198435110(+)	`AGATAC/AACTAT`	1	--	int¹		1		WA	118
rs183900644^1,2		--	198435190(+)	`GCTCAC/TGCCTG`	1	--	int¹		0	--	--	--	--
rs188842295^1,2		--	198435193(+)	`CACGCC/TTGTAA`	1	--	int¹		0	--	--	--	--
rs11694913^1,2	C,H,	--	198435280(+)	`ACCCCG/ATCTCT`	1	--	int¹		3		NA	6
rs116185557^1,2		--	198435320(+)	`GTGGCG/ACACAC`	1	--	int¹		1		WA	118
rs193058061^1,2		--	198435368(+)	`AGAATC/TGCTTG`	1	--	int¹		0	--	--	--	--
rs13405404^1,2	C,	--	198435449(+)	`actccA/Gtctca`	1	--	int¹		0	--	--	--	--
rs187641759^1,2		--	198435594(+)	`TATAAC/TAGGCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RFTN2 (198435524 - 198540769 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RFTN2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RFTN2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RFTN2)

Utopia: connect your pdf to the dynamic
world of online information

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 130132	HGNC: 26402	AceView: C2orf11	Ensembl:ENSG00000162944	euGenes: HUgn130132
ECgene: RFTN2	H-InvDB: RFTN2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RFTN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RFTN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RFTN2 gene:
Search GeneIP for patents involving RFTN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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RFTN2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RFTN2

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFTN2

	SwitchGear 3'UTR luciferase reporter plasmids for RFTN2
	SwitchGear Promoter luciferase reporter plasmids for RFTN2

ThermoFisher Antibody for RFTN2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFTN2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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RFTN2 Gene

raftlin family member 2

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RFTN2 Gene

raftlin family member 2

Aliasesfor RFTN2 gene

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Genomic Viewsfor RFTN2 gene

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Protein Domains /Familiesfor RFTN2 gene

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External Searches for RFTN2 gene

Genome Databases showing RFTN2 gene

Other Databases showing RFTN2 gene

Specialized Databases showing RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

Genomic Views
for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

Expression
for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene

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for RFTN2 gene