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RFTN1 Gene

protein-coding   GIFtS: 51
GCID: GC03M016357

Raftlin, Lipid Raft Linker 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Raftlin, Lipid Raft Linker 11 2     RAFTLIN2
Raft-Linking Protein1 2 3     Proliferation-Inducing Protein 102
Cell Migration-Inducing Gene 2 Protein2 3     Proliferation-Inducing Protein 92
PIB102     raftlin2
PIG92     KIAA00843

External Ids:    HGNC: 302781   Entrez Gene: 231802   Ensembl: ENSG000001313787   UniProtKB: Q146993   

Export aliases for RFTN1 gene to outside databases

Previous GC identifers: GC03M016333 GC03M016290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RFTN1 Gene:
RFTN1 (raftlin, lipid raft linker 1) is a protein-coding gene. Diseases associated with RFTN1 include open-angle glaucoma, and primary open angle glaucoma. An important paralog of this gene is RFTN2.

UniProtKB/Swiss-Prot: RFTN1_HUMAN, Q14699
Function: May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen
receptor-mediated signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RFTN1 gene promoter:
         Tal-1   Pbx1a   FOXD3   Arnt   E47   FOXO4   FOXO1a   FOXO1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFTN1 promoter sequence
   Search Chromatin IP Primers for RFTN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.3

RFTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFTN1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016357:  view genomic region     (about GC identifiers)

Start:
16,355,081 bp from pter      End:
16,555,533 bp from pter
Size:
200,453 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RFTN1_HUMAN, Q14699 (See protein sequence)
Recommended Name: Raftlin  
Size: 578 amino acids; 63146 Da
Sequence caution: Sequence=AAH51336.1; Type=Erroneous initiation; Sequence=AAH69209.1; Type=Erroneous initiation;
Sequence=BAA07644.1; Type=Erroneous initiation;
Secondary accessions: Q0D2G0 Q496Y2 Q4QQI7 Q5JB48 Q7Z7P2

Explore the universe of human proteins at neXtProt for RFTN1: NX_Q14699

Explore proteomics data for RFTN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys147
  • Modification sites at PhosphoSitePlus

  • See RFTN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055965.1  
    ENSEMBL proteins: 
     ENSP00000475367   ENSP00000403926   ENSP00000334153   ENSP00000403997   ENSP00000409427  
     ENSP00000388718   ENSP00000410493   ENSP00000393216  

    RFTN1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for RFTN1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028169 Raftlin

    Graphical View of Domain Structure for InterPro Entry Q14699

    ProtoNet protein and cluster: Q14699

    UniProtKB/Swiss-Prot: RFTN1_HUMAN, Q14699
    Similarity: Belongs to the raftlin family


    RFTN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFTN1_HUMAN, Q14699
    Function: May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen
    receptor-mediated signaling

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA--
         
    RFTN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RFTN1:
     Decreased viability of wild-ty 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rftn1):
     hematopoietic system  immune system 

    RFTN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rftn1tm1Ayos for RFTN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RFTN1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFTN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFTN1

    miRNA
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    miRTarBase miRNAs that target RFTN1:
    hsa-mir-484 (MIRT041930)

    Block miRNA regulation of human, mouse, rat RFTN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RFTN1 (see all 10):
    hsa-miR-146b-3p hsa-miR-137 hsa-miR-1271 hsa-miR-200a hsa-miR-141 hsa-miR-182 hsa-miR-544 hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidRFTN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RFTN1
    Predesigned siRNA for gene silencing in human, mouse, rat RFTN1

    Gene Editing
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    OriGene ORF clones in mouse, rat for RFTN1
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    GenScript: all cDNA clones in your preferred vector: RFTN1 (NM_015150)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFTN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFTN1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFTN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFTN1_HUMAN, Q14699: Cell membrane; Lipid-anchor. Note=Associates with lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IDA--
    GO:0005886plasma membrane IDA--
    GO:0043234protein complex IDA--
    GO:0045121membrane raft IDA--

    RFTN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFTN1
    Interactions:

        Search GeneGlobe Interaction Network for RFTN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for RFTN1 (Q146992 ENSP000003341534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061872, ENSP000003081764MINT-7230971 STRING: ENSP00000308176
    ARID3AQ998562MINT-7230971
    CD19P153912MINT-7230971
    GTF2IP783472MINT-7230971
    IGHMP018712MINT-7230971
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033227dsRNA transport IMP--
    GO:0034138toll-like receptor 3 signaling pathway IMP--
    GO:0043330response to exogenous dsRNA IMP--

    RFTN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFTN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RFTN1 gene: 
    NM_015150.1  

    Unigene Cluster for RFTN1:

    Raftlin, lipid raft linker 1
    Hs.98910  [show with all ESTs]
    Unigene Representative Sequence: NM_015150
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607320 ENST00000432519(uc010hes.3) ENST00000334133(uc003cay.3)
    ENST00000483671 ENST00000451036 ENST00000495666 ENST00000484752 ENST00000470458
    ENST00000449415 ENST00000441460 ENST00000453536 ENST00000431547

    miRNA
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    Block miRNA regulation of human, mouse, rat RFTN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RFTN1 (see all 10):
    hsa-miR-146b-3p hsa-miR-137 hsa-miR-1271 hsa-miR-200a hsa-miR-141 hsa-miR-182 hsa-miR-544 hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidRFTN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RFTN1
    Predesigned siRNA for gene silencing in human, mouse, rat RFTN1
    Clone
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    OriGene clones in human, mouse for RFTN1 (see all 6)
    OriGene ORF clones in mouse, rat for RFTN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RFTN1 (NM_015150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFTN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFTN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RFTN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFTN1
      QuantiTect SYBR Green Assays in human, mouse, rat RFTN1
      QuantiFast Probe-based Assays in human, mouse, rat RFTN1

    Additional mRNA sequence: 

    AK074446.1 AK301024.1 AK303846.1 AK310258.1 AY237654.1 BC006400.2 BC014032.2 BC032349.1 
    BC051336.1 BC069209.1 BC098270.1 BC100667.1 BC100669.1 BC121795.1 BC128151.1 D42043.1 

    13 DOTS entries:

    DT.86840840  DT.447932  DT.95360830  DT.100782478  DT.92442105  DT.120899711  DT.97836437  DT.317341 
    DT.100685198  DT.101981055  DT.95214472  DT.95360834  DT.120899751 

    Selected AceView cDNA sequences (see all 377):

    BM909582 AW770906 CA447175 BQ063354 BQ642458 BM665893 BQ058735 BQ054446 
    BE856569 BQ054980 BQ058702 BQ058877 D42043 CF125660 AI401333 CD516133 
    AI250853 CF143545 AA127738 BG055991 AI677703 AA292519 AA235475 BU632698 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RFTN1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ·
    SP1:                    -           -     -     -     -     -           -                                                     -                                 
    SP2:                                            -     -     -           -                                                     -                                 
    SP3:                    -           -     -     -     -     -           -                                                                                       
    SP4:                                -     -     -     -     -           -                                                                                       
    SP5:                                                                                                                    -     -                                 

    ExUns: 18d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RFTN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RFTN1 expression in normal human tissues (normalized intensities)      RFTN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATATCGT
    RFTN1 Expression
    About this image


    RFTN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Hypothalamus
     
     Thyroid (Endocrine System)
     
     Adipose (Muscoskeletal System)
     
     Tonsil (Hematopoietic System)
    RFTN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFTN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98910

    UniProtKB/Swiss-Prot: RFTN1_HUMAN, Q14699
    Tissue specificity: Specifically expressed by B-cells (at protein level)

        Custom PCR Arrays for RFTN1
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    QuantiFast Probe-based Assays in human, mouse, rat RFTN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFTN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RFTN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rftn11 , 5 raftlin lipid raft linker 11, 5 78.52(n)1
    73.52(a)1
      17 (25.86 cM)5
    764381  NM_181397.21  NP_852062.11 
     499922575 
    chicken
    (Gallus gallus)
    Aves RFTN11 raftlin, lipid raft linker 1 68.72(n)
    67.83(a)
      395109  NM_204458.1  NP_989789.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFTN16
    raftlin, lipid raft linker 1
    50(a)
    1 ↔ 1
    6(34925705-35054635)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rftn11 raftlin, lipid raft linker 1 60.54(n)
    54.14(a)
      100127747  NM_001113084.1  NP_001106555.1 
    zebrafish
    (Danio rerio)
    Actinopterygii RFTN1 (2 of 2)6
    rftn1a6
    raftlin, lipid raft linker 1a
    33(a)
    26(a)
    many → 1
    many → 1
    16(52120700-52299257) ENSDARG00000086499
    19(20783670-20870361) ENSDARG00000070831


    ENSEMBL Gene Tree for RFTN1 (if available)
    TreeFam Gene Tree for RFTN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RFTN1 gene
    RFTN22  
    1 SIMAP similar gene for RFTN1 using alignment to 9 protein entries:     RFTN1_HUMAN (see all proteins):
    RFTN2

    RFTN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RFTN1
    PGOHUM00000233683


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RFTN1 (see all 4366)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8424251,2
    C,F,A--16356869(-) GAGGCA/GGGCTG 1 -- int15Minor allele frequency- G:0.40NA WA CSA 10
    rs1906000551,2
    --16356961(+) GAAAAC/GACTTG 1 -- int10--------
    rs5630141,2
    C,F,A--16357048(-) CATCAA/GTGTCT 1 -- int113Minor allele frequency- G:0.43NA WA CSA EA 512
    rs1164134901,2
    C,F--16357052(+) ACTGAT/CGTAAG 1 -- int11Minor allele frequency- C:0.02WA 118
    rs6898941,2
    C,F,H--16357082(-) ACAAAT/CACCTT 1 -- int115Minor allele frequency- C:0.28MN NS EA CSA WA NA 1372
    rs1164642471,2
    C,F--16357165(+) CTCTTT/CCTACA 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1144833651,2
    C,F--16357241(+) CACCAC/TGTCAT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1412973121,2
    C--16357276(+) ATAGTA/GAATGG 1 -- int10--------
    rs622339191,2
    C,F--16357348(+) ACTCAA/CTCCTC 1 -- int17Minor allele frequency- C:0.14NA CSA WA EA 365
    rs1450565991,2
    C--16357390(+) CGTAAA/GTAACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RFTN1 (16355081 - 16555533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RFTN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724971CNV Deletion23290073
    esv2724973CNV Deletion23290073
    esv2659741CNV Deletion23128226
    nsv876585CNV Gain21882294
    nsv834625CNV Gain17160897
    esv7245CNV Gain19470904
    nsv834623CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for RFTN1:    About MalaCards
    open-angle glaucoma    primary open angle glaucoma    glaucoma    mantle cell lymphoma
    obesity    alzheimer's disease    breast cancer


    RFTN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): RFTN1
    Human Genome Epidemiology (HuGE) Navigator: RFTN1 (4 documents)

    Export disorders for RFTN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFTN1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RFTN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction. (PubMed id 12805216)1, 2, 3, 9 Saeki K.... Yoshimura A. (EMBO J. 2003)
    2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PubMed id 20395239)1, 4 Macgregor S....Mackey D.A. (Hum. Mol. Genet. 2010)
    5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    6. Common body mass index-associated variants confer risk of extreme obesity. (PubMed id 19553259)1, 4 Cotsapas C....Daly M.J. (Hum. Mol. Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer. (PubMed id 23645746)1 Gkretsi V....Tsezou A. (Anticancer Res. 2013)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma. (PubMed id 22222511)1 Chen J.H....Zhang M. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23180 HGNC: 30278 AceView: RAFTLIN Ensembl:ENSG00000131378 euGenes: HUgn23180
    ECgene: RFTN1 H-InvDB: RFTN1

    (According to HUGE)
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    HUGE: KIAA0084

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RFTN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RFTN1 gene:
    Search GeneIP for patents involving RFTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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