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Aliases for RFTN1 Gene

Aliases for RFTN1 Gene

  • Raftlin, Lipid Raft Linker 1 2 3
  • Raft-Linking Protein 2 3 4
  • Cell Migration-Inducing Gene 2 Protein 3 4
  • Proliferation-Inducing Protein 10 3
  • Proliferation-Inducing Protein 9 3
  • KIAA0084 4
  • RAFTLIN 3
  • PIB10 3
  • PIG9 3
  • MIG2 3

External Ids for RFTN1 Gene

Summaries for RFTN1 Gene

GeneCards Summary for RFTN1 Gene

RFTN1 (Raftlin, Lipid Raft Linker 1) is a Protein Coding gene. An important paralog of this gene is RFTN2.

UniProtKB/Swiss-Prot for RFTN1 Gene

  • May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFTN1 Gene

Genomics for RFTN1 Gene

Genomic Location for RFTN1 Gene

Start:
16,313,574 bp from pter
End:
16,514,026 bp from pter
Size:
200,453 bases
Orientation:
Minus strand

Genomic View for RFTN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFTN1 Gene

Regulatory Elements for RFTN1 Gene

Proteins for RFTN1 Gene

  • Protein details for RFTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14699-RFTN1_HUMAN
    Recommended name:
    Raftlin
    Protein Accession:
    Q14699
    Secondary Accessions:
    • Q0D2G0
    • Q496Y2
    • Q4QQI7
    • Q5JB48
    • Q7Z7P2

    Protein attributes for RFTN1 Gene

    Size:
    578 amino acids
    Molecular mass:
    63146 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH51336.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH69209.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA07644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RFTN1 Gene

Proteomics data for RFTN1 Gene at MOPED

Post-translational modifications for RFTN1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys147

No data available for DME Specific Peptides for RFTN1 Gene

Domains for RFTN1 Gene

Protein Domains for RFTN1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RFTN1_HUMAN
Family:
  • Belongs to the raftlin family.:
    • Q14699
genes like me logo Genes that share domains with RFTN1: view

No data available for Gene Families for RFTN1 Gene

Function for RFTN1 Gene

Molecular function for RFTN1 Gene

UniProtKB/Swiss-Prot Function: May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.

Gene Ontology (GO) - Molecular Function for RFTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
genes like me logo Genes that share ontologies with RFTN1: view

Phenotypes for RFTN1 Gene

genes like me logo Genes that share phenotypes with RFTN1: view

Animal Models for RFTN1 Gene

MGI Knock Outs for RFTN1:

miRNA for RFTN1 Gene

miRTarBase miRNAs that target RFTN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RFTN1 Gene

Localization for RFTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFTN1 Gene

Cell membrane; Lipid-anchor. Note=Associates with lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFTN1 Gene COMPARTMENTS Subcellular localization image for RFTN1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RFTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21266579
GO:0005768 endosome IDA 21266579
GO:0005886 plasma membrane IDA 12805216
GO:0043234 protein complex IDA 21266579
GO:0045121 membrane raft IDA 12805216
genes like me logo Genes that share ontologies with RFTN1: view

Pathways for RFTN1 Gene

SuperPathways for RFTN1 Gene

No Data Available

Interacting Proteins for RFTN1 Gene

Selected Interacting proteins: Q14699-RFTN1_HUMAN for RFTN1 Gene via MINT

Gene Ontology (GO) - Biological Process for RFTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IMP 12805216
GO:0002457 T cell antigen processing and presentation ISS --
GO:0032596 protein transport into membrane raft ISS --
GO:0032620 interleukin-17 production ISS --
GO:0033227 dsRNA transport IMP 21266579
genes like me logo Genes that share ontologies with RFTN1: view

No data available for Pathways by source for RFTN1 Gene

Transcripts for RFTN1 Gene

Unigene Clusters for RFTN1 Gene

Raftlin, lipid raft linker 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFTN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: - - -
SP11: - -

ExUns: 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RFTN1 Gene

GeneLoc Exon Structure for
RFTN1
ECgene alternative splicing isoforms for
RFTN1

Expression for RFTN1 Gene

mRNA expression in normal human tissues for RFTN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RFTN1 Gene

SOURCE GeneReport for Unigene cluster for RFTN1 Gene Hs.98910

mRNA Expression by UniProt/SwissProt for RFTN1 Gene

Q14699-RFTN1_HUMAN
Tissue specificity: Specifically expressed by B-cells (at protein level).
genes like me logo Genes that share expressions with RFTN1: view

Orthologs for RFTN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFTN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFTN1 36
  • 99.54 (n)
  • 99.65 (a)
RFTN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RFTN1 37
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFTN1 36
  • 86.06 (n)
  • 81.6 (a)
RFTN1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rftn1 36
  • 78.52 (n)
  • 73.52 (a)
Rftn1 16
Rftn1 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RFTN1 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFTN1 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rftn1 36
  • 78.33 (n)
  • 73.52 (a)
chicken
(Gallus gallus)
Aves RFTN1 36
  • 68.72 (n)
  • 67.83 (a)
RFTN1 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RFTN1 37
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rftn1 36
  • 60.54 (n)
  • 54.14 (a)
zebrafish
(Danio rerio)
Actinopterygii RFTN1 (2 of 2) 37
  • 33 (a)
OneToMany
rftn1a 37
  • 26 (a)
OneToMany
Species with no ortholog for RFTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFTN1 Gene

ENSEMBL:
Gene Tree for RFTN1 (if available)
TreeFam:
Gene Tree for RFTN1 (if available)

Paralogs for RFTN1 Gene

Paralogs for RFTN1 Gene

Selected SIMAP similar genes for RFTN1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for RFTN1 Gene

genes like me logo Genes that share paralogs with RFTN1: view

Variants for RFTN1 Gene

Sequence variations from dbSNP and Humsavar for RFTN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs471336 -- 16,384,920(-) TATTA(C/T)GCTCT intron-variant
rs475961 -- 16,368,390(-) CCGGC(C/T)GAATA intron-variant
rs479713 -- 16,358,633(+) CTGGG(G/T)GCTGC intron-variant
rs480301 -- 16,372,370(-) AATGA(A/T)TCAGG intron-variant
rs483050 -- 16,378,672(-) CTCTC(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFTN1 Gene

Variant ID Type Subtype PubMed ID
nsv876585 CNV Gain 21882294
nsv834623 CNV Gain 17160897
esv2724971 CNV Deletion 23290073
esv7245 CNV Gain 19470904
esv2724973 CNV Deletion 23290073
esv2659741 CNV Deletion 23128226
nsv834625 CNV Gain 17160897

Relevant External Links for RFTN1 Gene

HapMap Linkage Disequilibrium report
RFTN1

Disorders for RFTN1 Gene

Relevant External Links for RFTN1

Genetic Association Database (GAD)
RFTN1
Human Genome Epidemiology (HuGE) Navigator
RFTN1
genes like me logo Genes that share disorders with RFTN1: view

No data available for UniProtKB/Swiss-Prot for RFTN1 Gene

Publications for RFTN1 Gene

  1. The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction. (PMID: 12805216) Saeki K. … Yoshimura A. (EMBO J. 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C. … Daly M.J. (Hum. Mol. Genet. 2009) 3 49
  5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 49

Products for RFTN1 Gene

Sources for RFTN1 Gene

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