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Aliases for RFTN1 Gene

Aliases for RFTN1 Gene

  • Raftlin, Lipid Raft Linker 1 2 3 5
  • Raft-Linking Protein 2 3 4
  • Cell Migration-Inducing Gene 2 Protein 3 4
  • Proliferation-Inducing Protein 10 3
  • Proliferation-Inducing Protein 9 3
  • KIAA0084 4
  • PIB10 3
  • MIG2 3
  • PIG9 3

External Ids for RFTN1 Gene

Previous GeneCards Identifiers for RFTN1 Gene

  • GC03M016333
  • GC03M016290

Summaries for RFTN1 Gene

GeneCards Summary for RFTN1 Gene

RFTN1 (Raftlin, Lipid Raft Linker 1) is a Protein Coding gene. GO annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is RFTN2.

UniProtKB/Swiss-Prot for RFTN1 Gene

  • May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFTN1 Gene

Genomics for RFTN1 Gene

Regulatory Elements for RFTN1 Gene

Enhancers for RFTN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RFTN1 on UCSC Golden Path with GeneCards custom track

Promoters for RFTN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RFTN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RFTN1 Gene

16,313,574 bp from pter
16,514,026 bp from pter
200,453 bases
Minus strand

Genomic View for RFTN1 Gene

Genes around RFTN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFTN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFTN1 Gene

Proteins for RFTN1 Gene

  • Protein details for RFTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q0D2G0
    • Q496Y2
    • Q4QQI7
    • Q5JB48
    • Q7Z7P2

    Protein attributes for RFTN1 Gene

    578 amino acids
    Molecular mass:
    63146 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH51336.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH69209.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA07644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RFTN1 Gene

Proteomics data for RFTN1 Gene at MOPED

Post-translational modifications for RFTN1 Gene

  • Ubiquitination at Lys 147
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RFTN1
  • Cloud-Clone Corp. Antibodies for RFTN1

No data available for DME Specific Peptides for RFTN1 Gene

Domains & Families for RFTN1 Gene

Protein Domains for RFTN1 Gene


Suggested Antigen Peptide Sequences for RFTN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the raftlin family.
  • Belongs to the raftlin family.
genes like me logo Genes that share domains with RFTN1: view

No data available for Gene Families for RFTN1 Gene

Function for RFTN1 Gene

Molecular function for RFTN1 Gene

UniProtKB/Swiss-Prot Function:
May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.
genes like me logo Genes that share phenotypes with RFTN1: view

Animal Models for RFTN1 Gene

MGI Knock Outs for RFTN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for RFTN1

miRNA for RFTN1 Gene

miRTarBase miRNAs that target RFTN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RFTN1 Gene

Localization for RFTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFTN1 Gene

Cell membrane; Lipid-anchor. Note=Associates with lipid rafts.

Subcellular locations from

Jensen Localization Image for RFTN1 Gene COMPARTMENTS Subcellular localization image for RFTN1 gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RFTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21266579
GO:0005768 endosome IDA 21266579
GO:0005886 plasma membrane IDA 12805216
GO:0043234 protein complex IDA 21266579
genes like me logo Genes that share ontologies with RFTN1: view

Pathways & Interactions for RFTN1 Gene

SuperPathways for RFTN1 Gene

No Data Available

Interacting Proteins for RFTN1 Gene

Selected Interacting proteins: Q14699-RFTN1_HUMAN for RFTN1 Gene via MINT

Gene Ontology (GO) - Biological Process for RFTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IMP 12805216
GO:0002457 T cell antigen processing and presentation IEA,ISS --
GO:0032620 interleukin-17 production IEA,ISS --
GO:0034138 toll-like receptor 3 signaling pathway IMP 21266579
GO:0040007 growth IMP 12805216
genes like me logo Genes that share ontologies with RFTN1: view

No data available for Pathways by source and SIGNOR curated interactions for RFTN1 Gene

Drugs & Compounds for RFTN1 Gene

No Compound Related Data Available

Transcripts for RFTN1 Gene

Unigene Clusters for RFTN1 Gene

Raftlin, lipid raft linker 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFTN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - -
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: - - -
SP11: - -

ExUns: 18d

Relevant External Links for RFTN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFTN1 Gene

mRNA expression in normal human tissues for RFTN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RFTN1 Gene

This gene is overexpressed in Breast (39.7) and Lymph node (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RFTN1 Gene

SOURCE GeneReport for Unigene cluster for RFTN1 Gene Hs.98910

mRNA Expression by UniProt/SwissProt for RFTN1 Gene

Tissue specificity: Specifically expressed by B-cells (at protein level).
genes like me logo Genes that share expression patterns with RFTN1: view

Protein tissue co-expression partners for RFTN1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for RFTN1 Gene

Orthologs for RFTN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFTN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RFTN1 35
  • 86.06 (n)
  • 81.6 (a)
RFTN1 36
  • 77 (a)
(Mus musculus)
Mammalia Rftn1 35
  • 78.52 (n)
  • 73.52 (a)
Rftn1 16
Rftn1 36
  • 68 (a)
(Pan troglodytes)
Mammalia RFTN1 35
  • 99.54 (n)
  • 99.65 (a)
RFTN1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rftn1 35
  • 78.33 (n)
  • 73.52 (a)
(Bos Taurus)
Mammalia RFTN1 36
  • 56 (a)
(Monodelphis domestica)
Mammalia RFTN1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia RFTN1 36
  • 62 (a)
(Gallus gallus)
Aves RFTN1 35
  • 68.72 (n)
  • 67.83 (a)
RFTN1 36
  • 54 (a)
(Anolis carolinensis)
Reptilia RFTN1 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rftn1 35
  • 60.54 (n)
  • 54.14 (a)
(Danio rerio)
Actinopterygii RFTN1 (2 of 2) 36
  • 33 (a)
rftn1a 36
  • 26 (a)
Species with no ortholog for RFTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFTN1 Gene

Gene Tree for RFTN1 (if available)
Gene Tree for RFTN1 (if available)

Paralogs for RFTN1 Gene

Paralogs for RFTN1 Gene

(1) SIMAP similar genes for RFTN1 Gene using alignment to 9 proteins: Pseudogenes for RFTN1 Gene

genes like me logo Genes that share paralogs with RFTN1: view

Variants for RFTN1 Gene

Sequence variations from dbSNP and Humsavar for RFTN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_051317 -
VAR_061699 -
rs713352 -- 16,399,671(-) CGGTC(A/G)TGGAT intron-variant
rs734276 -- 16,400,541(-) GTTTG(C/G)GAATA intron-variant
rs735592 -- 16,400,156(+) GGGCT(C/G)TATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFTN1 Gene

Variant ID Type Subtype PubMed ID
nsv876585 CNV Gain 21882294
nsv834623 CNV Gain 17160897
esv2724971 CNV Deletion 23290073
esv7245 CNV Gain 19470904
esv2724973 CNV Deletion 23290073
esv2659741 CNV Deletion 23128226
nsv834625 CNV Gain 17160897

Variation tolerance for RFTN1 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RFTN1 Gene

Disorders for RFTN1 Gene

Relevant External Links for RFTN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RFTN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFTN1 Gene

Publications for RFTN1 Gene

  1. The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction. (PMID: 12805216) Saeki K. … Yoshimura A. (EMBO J. 2003) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer. (PMID: 23645746) Gkretsi V. … Tsezou A. (Anticancer Res. 2013) 3
  5. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3

Products for RFTN1 Gene

Sources for RFTN1 Gene