Aliases for RFT1 Gene
External Ids for RFT1 Gene
This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008]
GeneCards Summary for RFT1 Gene
RFT1 (RFT1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with RFT1 include congenital disorder of glycosylation, type in. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include lipid transporter activity. An important paralog of this gene is ENSG00000272305.
UniProtKB/Swiss-Prot for RFT1 Gene
May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.