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Aliases for RFPL4B Gene

Aliases for RFPL4B Gene

  • Ret Finger Protein Like 4B 2 3 5
  • RING Finger Protein 211 3 4
  • RNF211 3 4
  • Ret Finger Protein-Like 4B 3

External Ids for RFPL4B Gene

Previous GeneCards Identifiers for RFPL4B Gene

  • GC06P112776
  • GC06P112668
  • GC06P110243

Summaries for RFPL4B Gene

GeneCards Summary for RFPL4B Gene

RFPL4B (Ret Finger Protein Like 4B) is a Protein Coding gene. An important paralog of this gene is RFPL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL4B Gene

Genomics for RFPL4B Gene

Regulatory Elements for RFPL4B Gene

Enhancers for RFPL4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RFPL4B on UCSC Golden Path with GeneCards custom track

Genomic Location for RFPL4B Gene

112,347,330 bp from pter
112,351,296 bp from pter
3,967 bases
Plus strand

Genomic View for RFPL4B Gene

Genes around RFPL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL4B Gene

Proteins for RFPL4B Gene

  • Protein details for RFPL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ret finger protein-like 4B
    Protein Accession:
    Secondary Accessions:
    • A2RU91

    Protein attributes for RFPL4B Gene

    263 amino acids
    Molecular mass:
    29922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RFPL4B Gene

Post-translational modifications for RFPL4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFPL4B Gene

Domains & Families for RFPL4B Gene

Gene Families for RFPL4B Gene

Suggested Antigen Peptide Sequences for RFPL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL4B: view

Function for RFPL4B Gene

Gene Ontology (GO) - Molecular Function for RFPL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RFPL4B: view

Phenotypes for RFPL4B Gene

genes like me logo Genes that share phenotypes with RFPL4B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL4B Gene

Localization for RFPL4B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RFPL4B Gene

Pathways & Interactions for RFPL4B Gene

SuperPathways for RFPL4B Gene

No Data Available

Interacting Proteins for RFPL4B Gene

Gene Ontology (GO) - Biological Process for RFPL4B Gene


No data available for Pathways by source and SIGNOR curated interactions for RFPL4B Gene

Drugs & Compounds for RFPL4B Gene

No Compound Related Data Available

Transcripts for RFPL4B Gene

mRNA/cDNA for RFPL4B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL4B Gene

Ret finger protein-like 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL4B Gene

No ASD Table

Relevant External Links for RFPL4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFPL4B Gene

mRNA expression in normal human tissues for RFPL4B Gene

mRNA differential expression in normal tissues according to GTEx for RFPL4B Gene

This gene is overexpressed in Testis (x33.1).

NURSA nuclear receptor signaling pathways regulating expression of RFPL4B Gene:


SOURCE GeneReport for Unigene cluster for RFPL4B Gene:

genes like me logo Genes that share expression patterns with RFPL4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RFPL4B Gene

Orthologs for RFPL4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFPL4B 34
  • 97.47 (n)
  • 93.16 (a)
  • 93 (a)
(Canis familiaris)
Mammalia RFPL4B 35
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 18 (a)
Species where no ortholog for RFPL4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL4B Gene

Gene Tree for RFPL4B (if available)
Gene Tree for RFPL4B (if available)

Paralogs for RFPL4B Gene

Paralogs for RFPL4B Gene

(9) SIMAP similar genes for RFPL4B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RFPL4B: view

Variants for RFPL4B Gene

Sequence variations from dbSNP and Humsavar for RFPL4B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11153361 - 112,350,409(+) TGATG(A/G)TTTCT reference, missense
rs6917081 -- 112,350,598(+) TAGTG(A/C)AAAGA utr-variant-3-prime
rs6930560 -- 112,347,447(+) GTCCT(A/T)TTCTG intron-variant
rs6931103 -- 112,347,720(+) gcgcc(A/G)tggtt intron-variant
rs6939656 -- 112,350,410(+) GATGG(A/T)TTCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RFPL4B Gene

Variant ID Type Subtype PubMed ID
esv3610393 CNV gain 21293372
esv3610394 CNV loss 21293372
nsv1022212 CNV gain 25217958
nsv1023049 CNV gain 25217958

Variation tolerance for RFPL4B Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFPL4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL4B Gene

Disorders for RFPL4B Gene

Relevant External Links for RFPL4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RFPL4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL4B Gene

Publications for RFPL4B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for RFPL4B Gene

Sources for RFPL4B Gene

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