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Aliases for RFPL4B Gene

Aliases for RFPL4B Gene

  • Ret Finger Protein Like 4B 2 3 5
  • RING Finger Protein 211 3 4
  • RNF211 3 4
  • Ret Finger Protein-Like 4B 3

External Ids for RFPL4B Gene

Previous GeneCards Identifiers for RFPL4B Gene

  • GC06P112776
  • GC06P112668
  • GC06P110243

Summaries for RFPL4B Gene

GeneCards Summary for RFPL4B Gene

RFPL4B (Ret Finger Protein Like 4B) is a Protein Coding gene. An important paralog of this gene is ENSG00000281613.

Additional gene information for RFPL4B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL4B Gene

Genomics for RFPL4B Gene

GeneHancer (GH) Regulatory Elements for RFPL4B Gene

Promoters and enhancers for RFPL4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I112347 Promoter 0.9 EPDnew 550.8 0.0 -19 0.1 HDAC1 NFATC3 SMAD5 GTF2E2 GTF2B GTF2A2 GABPA POLR2B MTA3 NCOR1 RFPL4B GC06M112338 ENSG00000281613
GH06I112220 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.1 -123.4 -123392 6 ZBTB6 ZFP64 ZNF133 MZF1 ZNF697 GATA3 ZNF213 POLR2A PRDM10 CEBPB LAMA4 MFSD4B RNU6-1226P ENSG00000220506 BRD7P4 FCF1P5 LOC100128588 ENSG00000272356 RFPL4B ENSG00000270661
GH06I112228 Enhancer 0.6 dbSUPER 6.1 -118.6 -118586 0.8 ZNF316 JUND POLR2A YY2 CEBPB HNF4A MAFK PRDM1 NR2F2 RFPL4B LAMA4 ENSG00000270661 ENSG00000271208
GH06I112257 Enhancer 0.2 dbSUPER 4.2 -88.2 -88207 2.3 RNU6-1226P LOC100128588 LAMA4 RFPL4B ENSG00000281613 ENSG00000226440 LOC101927640 GC06M112326
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RFPL4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RFPL4B gene promoter:

Genomic Locations for RFPL4B Gene

Genomic Locations for RFPL4B Gene
chr6:112,347,330-112,351,296
(GRCh38/hg38)
Size:
3,967 bases
Orientation:
Plus strand
chr6:112,668,532-112,672,498
(GRCh37/hg19)

Genomic View for RFPL4B Gene

Genes around RFPL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL4B Gene

Proteins for RFPL4B Gene

  • Protein details for RFPL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWI9-RFPLB_HUMAN
    Recommended name:
    Ret finger protein-like 4B
    Protein Accession:
    Q6ZWI9
    Secondary Accessions:
    • A2RU91

    Protein attributes for RFPL4B Gene

    Size:
    263 amino acids
    Molecular mass:
    29922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RFPL4B Gene

Post-translational modifications for RFPL4B Gene

No Post-translational modifications

Other Protein References for RFPL4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFPL4B Gene

Domains & Families for RFPL4B Gene

Gene Families for RFPL4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RFPL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RFPL4B: view

No data available for UniProtKB/Swiss-Prot for RFPL4B Gene

Function for RFPL4B Gene

Phenotypes From GWAS Catalog for RFPL4B Gene

Gene Ontology (GO) - Molecular Function for RFPL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RFPL4B: view

Phenotypes for RFPL4B Gene

genes like me logo Genes that share phenotypes with RFPL4B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL4B Gene

Localization for RFPL4B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RFPL4B Gene

Pathways & Interactions for RFPL4B Gene

SuperPathways for RFPL4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RFPL4B Gene

Drugs & Compounds for RFPL4B Gene

No Compound Related Data Available

Transcripts for RFPL4B Gene

mRNA/cDNA for RFPL4B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL4B Gene

Ret finger protein-like 4B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL4B Gene

No ASD Table

Relevant External Links for RFPL4B Gene

GeneLoc Exon Structure for
RFPL4B
ECgene alternative splicing isoforms for
RFPL4B

Expression for RFPL4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RFPL4B Gene

mRNA differential expression in normal tissues according to GTEx for RFPL4B Gene

This gene is overexpressed in Testis (x33.1).

NURSA nuclear receptor signaling pathways regulating expression of RFPL4B Gene:

RFPL4B

SOURCE GeneReport for Unigene cluster for RFPL4B Gene:

Hs.448264
genes like me logo Genes that share expression patterns with RFPL4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFPL4B Gene

Orthologs for RFPL4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFPL4B 33 34
  • 97.47 (n)
dog
(Canis familiaris)
Mammalia RFPL4B 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 33 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
ManyToMany
Species where no ortholog for RFPL4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL4B Gene

ENSEMBL:
Gene Tree for RFPL4B (if available)
TreeFam:
Gene Tree for RFPL4B (if available)

Paralogs for RFPL4B Gene

Paralogs for RFPL4B Gene

(9) SIMAP similar genes for RFPL4B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RFPL4B: view

Variants for RFPL4B Gene

Sequence variations from dbSNP and Humsavar for RFPL4B Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000052819 -- 112,349,101(+) C/G intron_variant
rs1000082231 -- 112,327,576(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000130220 -- 112,308,192(+) C/T upstream_transcript_variant
rs1000210383 -- 112,333,331(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000226710 -- 112,310,444(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RFPL4B Gene

Variant ID Type Subtype PubMed ID
esv3610393 CNV gain 21293372
esv3610394 CNV loss 21293372
nsv1022212 CNV gain 25217958
nsv1023049 CNV gain 25217958

Variation tolerance for RFPL4B Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RFPL4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RFPL4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL4B Gene

Disorders for RFPL4B Gene

Additional Disease Information for RFPL4B

No disorders were found for RFPL4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL4B Gene

Publications for RFPL4B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for RFPL4B Gene

Sources for RFPL4B Gene

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