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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFPL4B Gene

protein-coding   GIFtS: 37
GCID: GC06P112668

Ret Finger Protein-Like 4B

  Search for RFPL4B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ret Finger Protein-Like 4B1 2
RNF2112 3
RING Finger Protein 2112 3

External Ids:    HGNC: 332641   Entrez Gene: 4422472   Ensembl: ENSG000002512587   UniProtKB: Q6ZWI93   

Export aliases for RFPL4B gene to outside databases

Previous GC identifers: GC06P112776 GC06P110243


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RFPL4B Gene: 
RFPL4B (ret finger protein-like 4B) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is RFPL1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFPL4B gene promoter:
         STAT5B   RFX1   AML1a   FOXD3   Nkx5-1   YY1   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFPL4B promoter sequence
   Search SABiosciences Chromatin IP Primers for RFPL4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFPL4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

RFPL4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFPL4B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P112668:  view genomic region     (about GC identifiers)

Start:
112,668,532 bp from pter      End:
112,672,498 bp from pter
Size:
3,967 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RFPLB_HUMAN, Q6ZWI9 (See protein sequence)
Recommended Name: Ret finger protein-like 4B  
Size: 263 amino acids; 29922 Da
Secondary accessions: A2RU91

Explore the universe of human proteins at neXtProt for RFPL4B: NX_Q6ZWI9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZWI9

  • RFPL4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001013756.2  
    ENSEMBL proteins: 
     ENSP00000423391  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/8 InterPro protein domains (see all 8):
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR013083 Znf_RING/FYVE/PHD
     IPR003879 Butyrophylin
     IPR006574 PRY

    Graphical View of Domain Structure for InterPro Entry Q6ZWI9

    ProtoNet protein and cluster: Q6ZWI9

    3 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: RFPLB_HUMAN, Q6ZWI9
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    RFPL4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    RFPL4B for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RFPL4B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RFPL4B (RFPLB)

    Search CenterWatch for drugs/clinical trials and news about RFPL4B / RFPLB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for RFPL4B gene: 
    NM_001013734.2  

    Unigene Cluster for RFPL4B:

    Ret finger protein-like 4B
    Hs.448264  [show with all ESTs]
    Unigene Representative Sequence: NM_001013734
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000441065(uc003pvx.1)
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    Additional mRNA sequence: 

    AK122906.1 BC132796.1 BC132798.1 

    1 DOTS entry:

    DT.101956465 

    2 AceView cDNA sequences:

    AK122906 BP432933 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFPL4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTCAGA
    RFPL4B Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.448264
        SABiosciences Custom PCR Arrays for RFPL4B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFPL4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RFPL4B gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF7776
    Uncharacterized protein
    28(a)
    possible ortholog
    2(564030-564628)
    zebrafish
    (Danio rerio)
    Actinopterygii btr306
    bloodthirsty-related gene family, member 30
    12(a)
    possible ortholog
    19(49825613-49832914)
            Species with no ortholog for RFPL4B

    ENSEMBL Gene Tree for RFPL4B (if available)
    TreeFam Gene Tree for RFPL4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFPL4B gene
    RFPL12  MEFV2  RFPL4AL12  RFPL32  RFPL4A2  RFPL22  RNF392  
    9 SIMAP similar genes for RFPL4B using alignment to 1 protein entry:     RFPLB_HUMAN:
    RFPL1    RFPL2    RFPL3    RFPL4A    RFPL4AL1    TRIM11
    TRIM27    BTN3A3    TRIM39

    RFPL4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in RFPL4B are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449964101,2
    --112666550(+) GCAAAG/TATATG 1 -- us2k10--------
    rs1907492471,2
    --112666558(+) ATGAAA/GAAAAG 1 -- us2k10--------
    rs1816851331,2
    --112666569(+) AGAAAA/CCTCGT 1 -- us2k10--------
    rs1851548221,2
    --112666628(+) ATGGGC/GGTTCT 1 -- us2k10--------
    rs1422767721,2
    --112666644(+) GAACTA/GAAAAT 1 -- us2k10--------
    rs21858021,2
    C,H--112666684(-) tatatC/Tcagaa 1 -- us2k111Minor allele frequency- T:0.03NA WA CSA EA 372
    rs77558851,2
    C,F,A--112666774(+) agataG/Cagaat 1 -- us2k110Minor allele frequency- C:0.40NA WA CSA EA 372
    rs577078081,2
    C,F--112666958(+) GGTACC/TGAAAG 1 -- us2k12Minor allele frequency- T:0.06CSA WA 120
    rs1460966651,2
    --112667012(+) TAAAAA/GAAAAT 1 -- us2k10--------
    rs1390532931,2
    C--112667131(+) AAGGAA/GTACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RFPL4B (112668532 - 112672498 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RFPL4B: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RFPL4B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RFPL4B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RFPL4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 442247 HGNC: 33264 AceView: LOC442247 Ensembl:ENSG00000251258 euGenes: HUgn442247
    ECgene: RFPL4B H-InvDB: RFPL4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFPL4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RFPL4B gene:
    Search GeneIP for patents involving RFPL4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for RFPL4B
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     Proteins for RFPL4B
     Antibodies for RFPL4B
     ELISAs for RFPL4B
     CLIAs for RFPL4B
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     Gene Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFPL4B
     SwitchGear 3'UTR luciferase reporter plasmids for RFPL4B
     SwitchGear Promoter luciferase reporter plasmids for RFPL4B
     ThermoFisher Antibodies for RFPL4B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFPL4B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RFPL4B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RFPL4B
    Customized:
     lentivirus for stable overexpression of RFPL4B
     lentivirus expression plasmids for stable overexpression of RFPL4B
     adenovirus for overexpression of RFPL4B
     LSBio Antibodies in human, mouse, rat for RFPL4B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
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     Translational medicine
     Tissue-specific gene expresssion
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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