RFPL4B Gene
protein-coding GIFtS: 36
GCID: GC06P112668
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ret finger protein-like 4B
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Aliases
for RFPL4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ret Finger Protein-Like 4B1 2 | | RNF2111 2 3 | | RING Finger Protein 2112 3 |
Export aliases for RFPL4B gene to outside databasesPrevious GC identifers: GC06P112776 GC06P110243 |
Summaries
for RFPL4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RFPL4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RFPL4B gene promoter:
STAT5B RFX1 AML1a FOXD3 Nkx5-1 YY1 POU2F1 POU2F1b POU2F1a POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for RFPL4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFPL4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21RFPL4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P112668: view genomic region
(about GC identifiers)
Start:
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112,668,532 bp from pter |
End:
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112,672,498 bp from pter |
Size:
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3,967 bases |
Orientation:
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plus strand |
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Proteins
for RFPL4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RFPLB_HUMAN, Q6ZWI9 (See
protein sequence)Recommended Name: Ret finger protein-like 4B Size: 263 amino acids; 29922 Da
Secondary accessions: A2RU91Explore the universe of human proteins at neXtProt for RFPL4B: NX_Q6ZWI9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZWI9
RFPL4B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001013756.2
ENSEMBL proteins: ENSP00000423391
Human Recombinant Protein Products:
RFPL4B Antibody Products:
Assay Products for RFPL4B: |
Protein
Domains /
Families
for RFPL4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RFPL4B for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q6ZWI9ProtoNet protein and cluster: Q6ZWI9 3 Blocks protein families: IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: RFPLB_HUMAN, Q6ZWI9Similarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for RFPL4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL4B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RFPL4B (NM_001013734) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFPL4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFPL4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFPL4B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RFPL4B for ontologies About GeneDecksing
|
Pathways & Interactions
for RFPL4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RFPL4B
|
Drugs & Compounds
for RFPL4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RFPL4B
Search CenterWatch for drugs/clinical trials and news about RFPL4B / RFPLB
|
Transcripts
for RFPL4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RFPL4B gene: NM_001013734.2 Unigene Cluster for RFPL4B: Ret finger protein-like 4B Hs.448264 [show with all ESTs]Unigene Representative Sequence: NM_0010137341 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000441065(uc003pvx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL4B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RFPL4B (NM_001013734) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFPL4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFPL4B |
Additional cDNA sequence: AK122906.1 BC132796.1 BC132798.1 1 DOTS entry: DT.101956465 2 AceView cDNA sequences: AK122906 BP432933
GeneLoc Exon Structure
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Expression
for RFPL4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RFPL4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTTCAGA
About this image
SOURCE GeneReport for Unigene cluster: Hs.448264
SABiosciences Custom PCR Arrays for RFPL4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFPL4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RFPL4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFPL4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFPL4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFPL4B |
Orthologs
for RFPL4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RFPL4B gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for RFPL4B (if available)
TreeFam Gene Tree for RFPL4B (if available) |
Paralogs
for RFPL4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RFPL4B gene
- RFPL12 TRIML22 MEFV2 RFPL4AL12 RFPL4A2 RFPL32 RFPL22
9 SIMAP similar genes for RFPL4B using alignment to 1 protein entry: RFPLB_HUMAN:RFPL1 RFPL2 RFPL3 RFPL4A LOC729974 TRIM11
TRIM27 BTN3A3 TRIM39
RFPL4B for paralogs About GeneDecksing
|
Genomic Variants
for RFPL4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RFPL4B (112668532 - 112672498 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RFPL4B: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for RFPL4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RFPL4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RFPL4B gene integrated from 9 sources:
(articles sorted by number of sources associating them with RFPL4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RFPL4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RFPL4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RFPL4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RFPL4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RFPL4B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RFPL4B gene:
Search GeneIP for patents involving RFPL4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RFPL4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RFPL4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFPL4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFPL4B | | | OriGene Protein Over-expression Lysate for RFPL4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RFPL4B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RFPL4B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFPL4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFPL4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFPL4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFPL4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFPL4B |
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| | | | Search Tocris compounds for RFPL4B |
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 | | | RFPL4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFPL4B |
|  |  |  | | | | Search ThermoFisher Antibodies for RFPL4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFPL4B |
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