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Aliases for RFPL4AL1 Gene

Aliases for RFPL4AL1 Gene

  • Ret Finger Protein-Like 4A-Like 1 2 3

External Ids for RFPL4AL1 Gene

Previous GeneCards Identifiers for RFPL4AL1 Gene

  • GC19P056283

Summaries for RFPL4AL1 Gene

GeneCards Summary for RFPL4AL1 Gene

RFPL4AL1 (Ret Finger Protein-Like 4A-Like 1) is a Protein Coding gene. An important paralog of this gene is RFPL4A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL4AL1 Gene

Genomics for RFPL4AL1 Gene

Genomic Location for RFPL4AL1 Gene

55,769,118 bp from pter
55,773,423 bp from pter
4,306 bases
Plus strand

Genomic View for RFPL4AL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RFPL4AL1 Gene

No data available for Regulatory Elements for RFPL4AL1 Gene

Proteins for RFPL4AL1 Gene

  • Protein details for RFPL4AL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ret finger protein-like 4A-like protein 1
    Protein Accession:

    Protein attributes for RFPL4AL1 Gene

    287 amino acids
    Molecular mass:
    32249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RFPL4AL1 Gene

Proteomics data for RFPL4AL1 Gene at MOPED

Post-translational modifications for RFPL4AL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL4AL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFPL4AL1 Gene

Domains & Families for RFPL4AL1 Gene

Protein Domains for RFPL4AL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL4AL1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RFPL4AL1 Gene

Function for RFPL4AL1 Gene

Gene Ontology (GO) - Molecular Function for RFPL4AL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RFPL4AL1: view

Phenotypes for RFPL4AL1 Gene

GenomeRNAi human phenotypes for RFPL4AL1:
genes like me logo Genes that share phenotypes with RFPL4AL1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL4AL1 Gene

Localization for RFPL4AL1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RFPL4AL1 Gene

Pathways & Interactions for RFPL4AL1 Gene

SuperPathways for RFPL4AL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL4AL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RFPL4AL1 Gene

Drugs & Compounds for RFPL4AL1 Gene

No Compound Related Data Available

Transcripts for RFPL4AL1 Gene

mRNA/cDNA for RFPL4AL1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL4AL1 Gene

No ASD Table

Relevant External Links for RFPL4AL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFPL4AL1 Gene

mRNA expression in normal human tissues for RFPL4AL1 Gene

mRNA differential expression in normal tissues according to GTEx for RFPL4AL1 Gene

This gene is overexpressed in Liver (x24.6), Testis (x12.2), and Kidney - Cortex (x5.7).
genes like me logo Genes that share expression patterns with RFPL4AL1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RFPL4AL1 Gene

Orthologs for RFPL4AL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL4AL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 29 (a)
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
(Mus musculus)
Mammalia Rfpl4 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
-- 36
  • 97 (a)
-- 36
  • 97 (a)
-- 36
  • 96 (a)
-- 36
  • 96 (a)
(Gallus gallus)
Aves B-BTN2 36
  • 17 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 18 (a)
Species with no ortholog for RFPL4AL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL4AL1 Gene

Gene Tree for RFPL4AL1 (if available)
Gene Tree for RFPL4AL1 (if available)

Paralogs for RFPL4AL1 Gene

Paralogs for RFPL4AL1 Gene

(11) SIMAP similar genes for RFPL4AL1 Gene using alignment to 1 proteins: Pseudogenes for RFPL4AL1 Gene

genes like me logo Genes that share paralogs with RFPL4AL1: view

Variants for RFPL4AL1 Gene

Sequence variations from dbSNP and Humsavar for RFPL4AL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1805266 -- 55,769,189(+) AATCT(C/T)ATGGA intron-variant
rs1805267 -- 55,769,190(+) ATCTT(A/T)TGGAA intron-variant
rs1820103 -- 55,769,222(+) TGAGA(A/G)TCTAG intron-variant
rs1820104 -- 55,769,308(+) GGATA(A/T)TGGGA intron-variant
rs1820105 -- 55,771,572(+) CTTTC(A/G)GTGAA upstream-variant-2KB, intron-variant

Variation tolerance for RFPL4AL1 Gene

Gene Damage Index Score: 0.59; 12.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFPL4AL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RFPL4AL1 Gene

Disorders for RFPL4AL1 Gene

Relevant External Links for RFPL4AL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RFPL4AL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL4AL1 Gene

Publications for RFPL4AL1 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for RFPL4AL1 Gene

Sources for RFPL4AL1 Gene

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