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Aliases for RFPL4A Gene

Aliases for RFPL4A Gene

  • Ret Finger Protein-Like 4A 2 3
  • RNF210 3 4 6
  • Ret Finger Protein-Like 4 2 3
  • RING Finger Protein 210 3 4
  • RFPL4 3 4

External Ids for RFPL4A Gene

Previous Symbols for RFPL4A Gene

  • RFPL4

Summaries for RFPL4A Gene

GeneCards Summary for RFPL4A Gene

RFPL4A (Ret Finger Protein-Like 4A) is a Protein Coding gene. An important paralog of this gene is MEFV.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL4A Gene

Genomics for RFPL4A Gene

Genomic Location for RFPL4A Gene

Start:
55,759,014 bp from pter
End:
55,763,175 bp from pter
Size:
4,162 bases
Orientation:
Plus strand

Genomic View for RFPL4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFPL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL4A Gene

Regulatory Elements for RFPL4A Gene

Proteins for RFPL4A Gene

  • Protein details for RFPL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLU0-RFPLA_HUMAN
    Recommended name:
    Ret finger protein-like 4A
    Protein Accession:
    A6NLU0
    Secondary Accessions:

    Protein attributes for RFPL4A Gene

    Size:
    287 amino acids
    Molecular mass:
    32238 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RFPL4A Gene

neXtProt entry for RFPL4A Gene

Proteomics data for RFPL4A Gene at MOPED

Post-translational modifications for RFPL4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFPL4A Gene

Domains for RFPL4A Gene

Gene Families for RFPL4A Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RFPL4A Gene

UniProtKB/Swiss-Prot:

RFPLA_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • A6NLU0
Similarity:
  • Contains 1 RING-type zinc finger.:
    • A6NLU0
genes like me logo Genes that share domains with RFPL4A: view

Function for RFPL4A Gene

Gene Ontology (GO) - Molecular Function for RFPL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RFPL4A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RFPL4A Gene

Localization for RFPL4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFPL4A Gene COMPARTMENTS Subcellular localization image for RFPL4A gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for RFPL4A Gene

Pathways for RFPL4A Gene

SuperPathways for RFPL4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL4A Gene

None

No data available for Pathways by source for RFPL4A Gene

Transcripts for RFPL4A Gene

mRNA/cDNA for RFPL4A Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL4A Gene

Ret finger protein-like 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL4A Gene

No ASD Table

Relevant External Links for RFPL4A Gene

GeneLoc Exon Structure for
RFPL4A
ECgene alternative splicing isoforms for
RFPL4A

Expression for RFPL4A Gene

mRNA expression in normal human tissues for RFPL4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFPL4A Gene

This gene is overexpressed in Liver (23.2) and Testis (14.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFPL4A Gene

SOURCE GeneReport for Unigene cluster for RFPL4A Gene Hs.631553

genes like me logo Genes that share expressions with RFPL4A: view

Orthologs for RFPL4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
ManyToMany
-- 37
  • 97 (a)
ManyToMany
-- 37
  • 97 (a)
ManyToMany
-- 37
  • 96 (a)
ManyToMany
-- 37
  • 97 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rfpl4 16
Rfpl4 37
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 29 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 33 (a)
ManyToMany
Species with no ortholog for RFPL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL4A Gene

ENSEMBL:
Gene Tree for RFPL4A (if available)
TreeFam:
Gene Tree for RFPL4A (if available)

Paralogs for RFPL4A Gene

Paralogs for RFPL4A Gene

Selected SIMAP similar genes for RFPL4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RFPL4A: view

Variants for RFPL4A Gene

Sequence variations from dbSNP and Humsavar for RFPL4A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1841951 -- 55,758,437(+) TACAT(A/G)AGGAA upstream-variant-2KB
rs1841952 -- 55,758,526(+) GTAAC(G/T)TTTAA upstream-variant-2KB
rs2019946 -- 55,761,927(+) AGCCC(A/G)ATGGG missense, reference
rs2045865 -- 55,762,536(+) GCAGT(A/C)AAAGG intron-variant
rs2161475 -- 55,758,971(+) CTTTA(A/C)GGTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RFPL4A Gene

Variant ID Type Subtype PubMed ID
nsv833882 CNV Loss 17160897
nsv510927 CNV Complex 20534489
nsv912505 CNV Gain 21882294
nsv912506 CNV Gain 21882294
dgv1132e1 CNV Complex 17122850
nsv509753 CNV Insertion 20534489
nsv2556 CNV Insertion 18451855
nsv9772 CNV Loss 18304495
dgv1133e1 CNV Complex 17122850
essv183 CNV CNV 17122850
nsv828645 CNV Loss 20364138
nsv821063 CNV Duplication 20802225
esv24770 CNV Loss 19812545
dgv1134e1 CNV Complex 17122850
nsv514903 CNV Complex 21397061
nsv442473 CNV CNV 18776908
nsv435699 CNV Deletion 17901297
nsv482047 CNV Gain 20164927
esv2718988 CNV Deletion 23290073
esv6309 CNV Loss 19470904
esv2432344 CNV Deletion 19546169
esv2664981 CNV Deletion 23128226
esv3329 CNV Deletion 18987735

Relevant External Links for RFPL4A Gene

HapMap Linkage Disequilibrium report
RFPL4A

Disorders for RFPL4A Gene

(1) University of Copenhagen DISEASES for RFPL4A Gene

Relevant External Links for RFPL4A

Genetic Association Database (GAD)
RFPL4A
Human Genome Epidemiology (HuGE) Navigator
RFPL4A
genes like me logo Genes that share disorders with RFPL4A: view

No data available for UniProtKB/Swiss-Prot for RFPL4A Gene

Publications for RFPL4A Gene

  1. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells. (PMID: 11850190) Rajkovic A. … Matzuk M.M. (Mech. Dev. 2002) 2 3
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. (PMID: 16364311) Gruetter C. … Gruetter M.G. (FEBS Lett. 2006) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for RFPL4A Gene

Sources for RFPL4A Gene

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