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Aliases for RFPL4A Gene

Aliases for RFPL4A Gene

  • Ret Finger Protein Like 4A 2 3
  • Ret Finger Protein-Like 4 2 3
  • RING Finger Protein 210 3 4
  • RNF210 3 4
  • RFPL4 3 4
  • Ret Finger Protein-Like 4A 5

External Ids for RFPL4A Gene

Previous HGNC Symbols for RFPL4A Gene

  • RFPL4

Previous GeneCards Identifiers for RFPL4A Gene

  • GC19P060963
  • GC19P056270

Summaries for RFPL4A Gene

GeneCards Summary for RFPL4A Gene

RFPL4A (Ret Finger Protein Like 4A) is a Protein Coding gene. An important paralog of this gene is MEFV.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL4A Gene

Genomics for RFPL4A Gene

Regulatory Elements for RFPL4A Gene

Enhancers for RFPL4A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RFPL4A on UCSC Golden Path with GeneCards custom track

Genomic Location for RFPL4A Gene

Chromosome:
19
Start:
55,757,430 bp from pter
End:
55,763,419 bp from pter
Size:
5,990 bases
Orientation:
Plus strand

Genomic View for RFPL4A Gene

Genes around RFPL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL4A Gene

Proteins for RFPL4A Gene

  • Protein details for RFPL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLU0-RFPLA_HUMAN
    Recommended name:
    Ret finger protein-like 4A
    Protein Accession:
    A6NLU0

    Protein attributes for RFPL4A Gene

    Size:
    287 amino acids
    Molecular mass:
    32238 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RFPL4A Gene

neXtProt entry for RFPL4A Gene

Proteomics data for RFPL4A Gene at MOPED

Post-translational modifications for RFPL4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFPL4A Gene

Domains & Families for RFPL4A Gene

Gene Families for RFPL4A Gene

Protein Domains for RFPL4A Gene

Suggested Antigen Peptide Sequences for RFPL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLU0

UniProtKB/Swiss-Prot:

RFPLA_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL4A: view

Function for RFPL4A Gene

Phenotypes for RFPL4A Gene

genes like me logo Genes that share phenotypes with RFPL4A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL4A Gene

Localization for RFPL4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFPL4A Gene COMPARTMENTS Subcellular localization image for RFPL4A gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL4A Gene

Pathways & Interactions for RFPL4A Gene

SuperPathways for RFPL4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL4A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RFPL4A Gene

Drugs & Compounds for RFPL4A Gene

No Compound Related Data Available

Transcripts for RFPL4A Gene

mRNA/cDNA for RFPL4A Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL4A Gene

Ret finger protein-like 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL4A Gene

No ASD Table

Relevant External Links for RFPL4A Gene

GeneLoc Exon Structure for
RFPL4A
ECgene alternative splicing isoforms for
RFPL4A

Expression for RFPL4A Gene

mRNA expression in normal human tissues for RFPL4A Gene

mRNA differential expression in normal tissues according to GTEx for RFPL4A Gene

This gene is overexpressed in Liver (x23.2) and Testis (x14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFPL4A Gene



SOURCE GeneReport for Unigene cluster for RFPL4A Gene Hs.631553

genes like me logo Genes that share expression patterns with RFPL4A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RFPL4A Gene

Orthologs for RFPL4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL4A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Rfpl4 36
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
ManyToMany
Species with no ortholog for RFPL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL4A Gene

ENSEMBL:
Gene Tree for RFPL4A (if available)
TreeFam:
Gene Tree for RFPL4A (if available)

Paralogs for RFPL4A Gene

Paralogs for RFPL4A Gene

(11) SIMAP similar genes for RFPL4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RFPL4A: view

Variants for RFPL4A Gene

Sequence variations from dbSNP and Humsavar for RFPL4A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7260052 -- 55,757,672(+) TAACA(C/G)CCAAA upstream-variant-2KB, utr-variant-5-prime
rs12977935 -- 55,757,249(+) GGATA(A/G/T)CATTA upstream-variant-2KB
rs12980629 -- 55,758,765(+) TATAA(G/T)AGAAA upstream-variant-2KB, utr-variant-5-prime
rs8106001 -- 55,756,181(+) ttctg(C/T)cgaac upstream-variant-2KB
rs8106255 -- 55,756,360(+) tcctt(A/C)gacaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RFPL4A Gene

Variant ID Type Subtype PubMed ID
nsv833882 CNV Loss 17160897
nsv510927 CNV Complex 20534489
nsv912505 CNV Gain 21882294
nsv912506 CNV Gain 21882294
dgv1132e1 CNV Complex 17122850
nsv509753 CNV Insertion 20534489
nsv2556 CNV Insertion 18451855
nsv9772 CNV Loss 18304495
dgv1133e1 CNV Complex 17122850
essv183 CNV CNV 17122850
nsv828645 CNV Loss 20364138
nsv821063 CNV Duplication 20802225
esv24770 CNV Loss 19812545
dgv1134e1 CNV Complex 17122850
nsv514903 CNV Complex 21397061
nsv442473 CNV CNV 18776908
nsv435699 CNV Deletion 17901297
nsv482047 CNV Gain 20164927
esv2718988 CNV Deletion 23290073
esv6309 CNV Loss 19470904
esv2432344 CNV Deletion 19546169
esv2664981 CNV Deletion 23128226
esv3329 CNV Deletion 18987735

Variation tolerance for RFPL4A Gene

Gene Damage Index Score: 0.52; 11.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RFPL4A Gene

Disorders for RFPL4A Gene

Relevant External Links for RFPL4A

Genetic Association Database (GAD)
RFPL4A
Human Genome Epidemiology (HuGE) Navigator
RFPL4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFPL4A

No disorders were found for RFPL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL4A Gene

Publications for RFPL4A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells. (PMID: 11850190) Rajkovic A. … Matzuk M.M. (Mech. Dev. 2002) 2 3
  3. RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells. (PMID: 25605732) Naito A. … Ishii M. (J. Biol. Chem. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3

Products for RFPL4A Gene

Sources for RFPL4A Gene

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