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Aliases for RFPL3S Gene

Subcategory (RNA class) for RFPL3S Gene


Quality Score for this RNA gene is


Aliases for RFPL3S Gene

  • RFPL3 Antisense 2 3 5
  • Non-Protein Coding RNA 5 2 3
  • RFPL3 Antisense RNA 1 2 4
  • RFPL3-AS1 3 4
  • Ret Finger Protein-Like 3 Antisense Gene Protein 4
  • RFPL3 Antisense RNA 1 (Non-Protein Coding) 3
  • Ret Finger Protein-Like 3 Antisense 3
  • RFPL3 Antisense Gene Protein 1 4
  • NCRNA00005 3
  • RFPL3-AS 3
  • RFPL3ANT 3
  • RFPL3AS 3

External Ids for RFPL3S Gene

ORGUL Members for RFPL3S Gene

Previous HGNC Symbols for RFPL3S Gene

  • RFPL3-AS1

Previous GeneCards Identifiers for RFPL3S Gene

  • GC22M029451
  • GC22P029280
  • GC22M031080
  • GC22M032755
  • GC22M015717

Summaries for RFPL3S Gene

GeneCards Summary for RFPL3S Gene

RFPL3S (RFPL3 Antisense) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for RFPL3S Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL3S Gene

Genomics for RFPL3S Gene

Regulatory Elements for RFPL3S Gene

Enhancers for RFPL3S Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H032050 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9 +330.6 330577 2.8 PKNOX1 ZNF766 GLIS2 ATF7 FOS RUNX3 JUNB ZNF518A NFIL3 SMARCA4 SLC5A4 BPIFC ENSG00000241954 RFPL3S LOC100422292 IGLVIVOR22-2 LOC339666 SLC5A1 PIR57309
GH22H032410 1.2 FANTOM5 ENCODE 10.9 -29.5 -29496 2.8 ATF1 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ZNF143 ZNF207 FOS LOC100422292 FBXO7 ENSG00000241954 RFPL3S LOC339666 IGLVIVOR22-2 BPIFC RTCB RFPL2 RFPL3
GH22H031969 1 ENCODE 13 +411.5 411474 1.2 PKNOX1 ATF1 SIN3A GLI4 ZNF2 GLIS2 ZNF207 ZNF143 ZNF548 ATF7 IGLCOR22-2 LINC02558 RN7SL305P ENSG00000227813 AP1B1P2 ENSG00000230120 ENSG00000214125 RFPL3S EIF4ENIF1 RTCB
GH22H032406 0.9 Ensembl ENCODE 11.1 -25.5 -25538 1.7 HDGF BMI1 ELF1 DPF2 ZNF217 IKZF1 NBN HNF4A ZNF24 ETV6 SLC5A4 LOC100422292 ENSG00000241954 RFPL3S LOC339666 IGLVIVOR22-2 FBXO7 RTCB GC22P032387
GH22H032266 0.9 Ensembl ENCODE 10.6 +115.8 115797 0.5 CTCF ZNF654 NFIA TRIM22 REST BATF RAD21 YY1 NFIC ZNF692 ENSG00000234626 RFPL3 IGLVIVOR22-2 LOC339666 RFPL3S ENSG00000241954 LOC100422292 SLC5A1 CPSF1P1 RFPL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RFPL3S on UCSC Golden Path with GeneCards custom track

Genomic Locations for RFPL3S Gene

Genomic Locations for RFPL3S Gene
22,147 bases
Minus strand

Genomic View for RFPL3S Gene

Genes around RFPL3S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL3S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL3S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL3S Gene

Proteins for RFPL3S Gene

  • Protein details for RFPL3S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative protein RFPL3S
    Protein Accession:
    Secondary Accessions:
    • Q5TI83
    • Q5TI84

    Protein attributes for RFPL3S Gene

    107 amino acids
    Molecular mass:
    11739 Da
    Quaternary structure:
    No Data Available
    • The gene encoding RFPL3S is located on the opposite strand of the gene encoding RFPL3. Its transcription may play a role in RFPL3 transcription regulation.
    • Sequence=CAB38257.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAI19584.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for RFPL3S Gene

Post-translational modifications for RFPL3S Gene

No Post-translational modifications

Other Protein References for RFPL3S Gene

No data available for DME Specific Peptides for RFPL3S Gene

Domains & Families for RFPL3S Gene

Gene Families for RFPL3S Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RFPL3S Gene


Suggested Antigen Peptide Sequences for RFPL3S Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RFPL3S: view

No data available for UniProtKB/Swiss-Prot for RFPL3S Gene

Function for RFPL3S Gene

Molecular function for RFPL3S Gene

GENATLAS Biochemistry:
ret finger protein-like 3,antisense transcript,overlapping RFRL3

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL3S Gene

Localization for RFPL3S Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFPL3S gene
Compartment Confidence
mitochondrion 2
nucleus 2
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RFPL3S Gene

Pathways & Interactions for RFPL3S Gene

SuperPathways for RFPL3S Gene

No Data Available

Interacting Proteins for RFPL3S Gene

Gene Ontology (GO) - Biological Process for RFPL3S Gene


No data available for Pathways by source and SIGNOR curated interactions for RFPL3S Gene

Drugs & Compounds for RFPL3S Gene

No Compound Related Data Available

Transcripts for RFPL3S Gene

Unigene Clusters for RFPL3S Gene

RFPL3 antisense:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL3S Gene

No ASD Table

Relevant External Links for RFPL3S Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFPL3S Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RFPL3S Gene

mRNA differential expression in normal tissues according to GTEx for RFPL3S Gene

This gene is overexpressed in Testis (x22.5).

Protein differential expression in normal tissues from HIPED for RFPL3S Gene

This gene is overexpressed in Heart (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RFPL3S Gene

Protein tissue co-expression partners for RFPL3S Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RFPL3S Gene:


SOURCE GeneReport for Unigene cluster for RFPL3S Gene:


mRNA Expression by UniProt/SwissProt for RFPL3S Gene:

Tissue specificity: Strongly expressed in the testis and weakly in brain, placenta and pancreas.
genes like me logo Genes that share expression patterns with RFPL3S: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFPL3S Gene

Orthologs for RFPL3S Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for RFPL3S Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFPL3S 34
  • 94 (a)
Species where no ortholog for RFPL3S was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL3S Gene

Gene Tree for RFPL3S (if available)
Gene Tree for RFPL3S (if available)

Paralogs for RFPL3S Gene Pseudogenes for RFPL3S Gene

genes like me logo Genes that share paralogs with RFPL3S: view

No data available for Paralogs for RFPL3S Gene

Variants for RFPL3S Gene

Sequence variations from dbSNP and Humsavar for RFPL3S Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000516187 -- 32,372,389(+) ATCCA(C/T)CCACC upstream-variant-2KB
rs1000842750 -- 32,369,706(+) TTAAC(A/T)GTTTT intron-variant
rs1001141962 -- 32,365,964(+) AGGAA(A/C)AATAA intron-variant
rs1001245112 -- 32,371,375(+) GAACC(C/T)GGGAG upstream-variant-2KB
rs1001501602 -- 32,365,302(+) AAAAG(C/T)AAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFPL3S Gene

Variant ID Type Subtype PubMed ID
nsv588895 CNV gain 21841781
nsv519170 CNV gain 19592680
nsv459874 CNV gain 19166990
esv3893474 CNV gain 25118596
esv3575476 CNV gain 25503493
esv2422247 CNV duplication 17116639

Variation tolerance for RFPL3S Gene

Gene Damage Index Score: 0.92; 19.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFPL3S Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL3S Gene

Disorders for RFPL3S Gene

Relevant External Links for RFPL3S

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RFPL3S Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL3S Gene

Publications for RFPL3S Gene

  1. Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E … Dumanski JP (Genome research 1999) 2 3 4 22 60
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 45 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 60

Products for RFPL3S Gene

Sources for RFPL3S Gene

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