Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RFPL3 Gene

Aliases for RFPL3 Gene

  • Ret Finger Protein Like 3 2 3
  • Ret Finger Protein-Like 3 5

External Ids for RFPL3 Gene

Previous GeneCards Identifiers for RFPL3 Gene

  • GC22P029449
  • GC22P031075
  • GC22P031078
  • GC22P032750
  • GC22P015708

Summaries for RFPL3 Gene

GeneCards Summary for RFPL3 Gene

RFPL3 (Ret Finger Protein Like 3) is a Protein Coding gene. An important paralog of this gene is RFPL4A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL3 Gene

Genomics for RFPL3 Gene

Regulatory Elements for RFPL3 Gene

Enhancers for RFPL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RFPL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RFPL3 Gene

32,354,885 bp from pter
32,361,161 bp from pter
6,277 bases
Plus strand

Genomic View for RFPL3 Gene

Genes around RFPL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL3 Gene

Proteins for RFPL3 Gene

  • Protein details for RFPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ret finger protein-like 3
    Protein Accession:
    Secondary Accessions:
    • A2A279
    • Q6IC03
    • Q6IC04
    • Q6NSX3
    • Q8N5R4

    Protein attributes for RFPL3 Gene

    317 amino acids
    Molecular mass:
    35386 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA09046.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RFPL3 Gene


neXtProt entry for RFPL3 Gene

Proteomics data for RFPL3 Gene at MOPED

Post-translational modifications for RFPL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFPL3 Gene

Domains & Families for RFPL3 Gene

Suggested Antigen Peptide Sequences for RFPL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL3: view

No data available for Gene Families for RFPL3 Gene

Function for RFPL3 Gene

Molecular function for RFPL3 Gene

GENATLAS Biochemistry:
ret finger protein-like 3,B box family

Gene Ontology (GO) - Molecular Function for RFPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RFPL3: view
genes like me logo Genes that share phenotypes with RFPL3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL3 Gene

Localization for RFPL3 Gene

Subcellular locations from

Jensen Localization Image for RFPL3 Gene COMPARTMENTS Subcellular localization image for RFPL3 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL3 Gene

Pathways & Interactions for RFPL3 Gene

SuperPathways for RFPL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for RFPL3 Gene

Drugs & Compounds for RFPL3 Gene

No Compound Related Data Available

Transcripts for RFPL3 Gene

mRNA/cDNA for RFPL3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL3 Gene

Ret finger protein-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL3 Gene

No ASD Table

Relevant External Links for RFPL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFPL3 Gene

mRNA expression in normal human tissues for RFPL3 Gene

mRNA differential expression in normal tissues according to GTEx for RFPL3 Gene

This gene is overexpressed in Testis (x34.0) and Brain - Cerebellar Hemisphere (x4.3).

SOURCE GeneReport for Unigene cluster for RFPL3 Gene Hs.558455

genes like me logo Genes that share expression patterns with RFPL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RFPL3 Gene

Orthologs for RFPL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFPL3 35
  • 98.26 (n)
  • 95.49 (a)
-- 36
  • 87 (a)
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
(Mus musculus)
Mammalia Mefv 36
  • 5 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 13 (a)
Species with no ortholog for RFPL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL3 Gene

Gene Tree for RFPL3 (if available)
Gene Tree for RFPL3 (if available)

Paralogs for RFPL3 Gene

Paralogs for RFPL3 Gene

(14) SIMAP similar genes for RFPL3 Gene using alignment to 1 proteins: Pseudogenes for RFPL3 Gene

genes like me logo Genes that share paralogs with RFPL3: view

Variants for RFPL3 Gene

Sequence variations from dbSNP and Humsavar for RFPL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs16987625 - 32,358,319(+) TTCCA(C/T)GGTCT reference, missense
rs9621427 - 32,358,399(+) CCAAG(A/C)TGAAG reference, missense
VAR_052093 -
VAR_059814 -
rs7289771 -- 32,356,252(+) GGGTG(C/T)GTCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RFPL3 Gene

Variant ID Type Subtype PubMed ID
esv2422247 CNV Duplication 17116639
nsv459874 CNV Gain 19166990

Variation tolerance for RFPL3 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.32; 76.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RFPL3 Gene

Disorders for RFPL3 Gene

Relevant External Links for RFPL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RFPL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL3 Gene

Publications for RFPL3 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E. … Dumanski J.P. (Genome Res. 1999) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Identification of RFPL3 protein as a novel E3 ubiquitin ligase modulating the integration activity of human immunodeficiency virus, type 1 preintegration complex using a microtiter plate-based assay. (PMID: 25107902) Tan B.H. … Suzuki Y. (J. Biol. Chem. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells. (PMID: 25481043) Chen W. … Deng W. (Oncotarget 2014) 3

Products for RFPL3 Gene

Sources for RFPL3 Gene