RFPL3 Gene
protein-coding GIFtS: 40
GCID: GC22P032750
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ret finger protein-like 3
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Aliases
for RFPL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ret Finger Protein-Like 31 2 |
Export aliases for RFPL3 gene to outside databasesPrevious GC identifers: GC22P029449 GC22P031075 GC22P031078 GC22P015708 |
Summaries
for RFPL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RFPL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RFPL3 gene promoter:
POU2F1 POU2F1b POU2F1a POU2F1c LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RFPL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFPL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12RFPL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P032750: view genomic region
(about GC identifiers)
Start:
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32,750,872 bp from pter |
End:
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32,757,148 bp from pter |
Size:
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6,277 bases |
Orientation:
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plus strand |
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Proteins
for RFPL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RFPL3_HUMAN, O75679 (See
protein sequence)Recommended Name: Ret finger protein-like 3 Size: 317 amino acids; 35386 Da
Sequence caution: Sequence=CAA09046.1; Type=Erroneous initiation;
Secondary accessions: A2A279 Q6IC03 Q6IC04 Q6NSX3 Q8N5R4Alternative splicing: 2 isoforms: O75679-1 O75679-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RFPL3: NX_O75679
RFPL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092005.1 NP_006595.1
ENSEMBL proteins: ENSP00000380609 ENSP00000249007 ENSP00000371520
Human Recombinant Protein Products:
RFPL3 Antibody Products:
Assay Products for RFPL3: |
Protein
Domains /
Families
for RFPL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RFPL3 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry O75679ProtoNet protein and cluster: O75679 3 Blocks protein families: IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: RFPL3_HUMAN, O75679Similarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for RFPL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for RFPL3:ret finger protein-like 3,B box family
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for RFPL3 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFPL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFPL3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RFPL3 for ontologies About GeneDecksing
|
Pathways & Interactions
for RFPL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RFPL3
|
Drugs & Compounds
for RFPL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RFPL3
Search CenterWatch for drugs/clinical trials and news about RFPL3
|
Transcripts
for RFPL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RFPL3 gene (2 alternative transcripts): NM_001098535.1 NM_006604.2 Unigene Cluster for RFPL3: Ret finger protein-like 3 Hs.558455 [show with all ESTs]Unigene Representative Sequence: AK0977383 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397468(uc010gwn.3) ENST00000249007(uc003amj.3) ENST00000382088
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for RFPL3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RFPL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFPL3 |
Additional cDNA sequence: AJ010232.1 AK097738.1 BC031689.1 BC069753.1 CR456564.1 1 DOTS entry: DT.91754466 10 AceView cDNA sequences: CR456564 AJ010232 NM_006604 BC031689 BX280855 AK097738 BC069753 BI826818 BI827007 BG207403
GeneLoc Exon Structure
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Expression
for RFPL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RFPL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RFPL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RFPL3
SOURCE GeneReport for Unigene cluster: Hs.558455
SABiosciences Expression via Pathway-Focused PCR Array including RFPL3: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFPL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RFPL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFPL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFPL3 |
Orthologs
for RFPL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for RFPL3 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for RFPL3 (if available)
TreeFam Gene Tree for RFPL3 (if available) |
Paralogs
for RFPL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RFPL3 gene
- RFPL11 2 TRIML22 MEFV2 RFPL4AL12 RFPL4A2 RFPL22 RFPL4B2
13 SIMAP similar genes for RFPL3 using alignment to 1 protein entry: RFPL3_HUMAN:RFPL1 RFPL2 LOC729974 RFPL4A MEFV TRIM27
TRIM39 RFPL4B BT3.3 BTN3A3 TRIM21 BTN1A1
BTNL9
RFPL3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RFPL3
PGOHUM00000241019
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Genomic Variants
for RFPL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RFPL3 (32750872 - 32757148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RFPL3
1 CNV: 5358 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFPL3 |
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Disorders
/ Diseases
for RFPL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RFPL3 for disorders About MalaCards
RFPL3 for disorders About GeneDecksing
OMIM gene information: 605970
OMIM disorders: --
Export disorders for RFPL3 gene to outside databases
|
Publications
for RFPL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RFPL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RFPL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PubMed id 10508838)1, 2, 3, 9 Seroussi E.... Dumanski J.P. (1999)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. (PubMed id 18656177)1 Bonnefont J....Krause K.H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RFPL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RFPL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing RFPL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RFPL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RFPL3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RFPL3 gene:
Search GeneIP for patents involving RFPL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RFPL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for RFPL3 | | OriGene shRNA RFP for RFPL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFPL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RFPL3 | | | OriGene Protein Over-expression Lysate for RFPL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RFPL3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFPL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RFPL3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RFPL3 | | OriGene Custom Protein Services for RFPL3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RFPL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RFPL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFPL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFPL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFPL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFPL3 |
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 | | | RFPL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RFPL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFPL3 |
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