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Aliases for RFPL3 Gene

Aliases for RFPL3 Gene

  • Ret Finger Protein Like 3 2 3 5

External Ids for RFPL3 Gene

Previous GeneCards Identifiers for RFPL3 Gene

  • GC22P029449
  • GC22P031075
  • GC22P031078
  • GC22P032750
  • GC22P015708

Summaries for RFPL3 Gene

GeneCards Summary for RFPL3 Gene

RFPL3 (Ret Finger Protein Like 3) is a Protein Coding gene. An important paralog of this gene is RFPL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL3 Gene

Genomics for RFPL3 Gene

Regulatory Elements for RFPL3 Gene

Enhancers for RFPL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F032266 0.9 Ensembl ENCODE 10.7 -88.6 -88630 0.5 CTCF ZNF654 NFIA TRIM22 REST RAD21 ZNF692 SMC3 ZNF143 ZXDB ENSG00000234626 RFPL3 IGLVIVOR22-2 LOC339666 ENSG00000241954 RFPL3S LOC100422292 SLC5A1 CPSF1P1 RFPL2
GH22F032473 1.4 FANTOM5 ENCODE 3.5 +120.8 120835 4.7 PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3 SP5 FBXO7 BPIFC SLC5A4 RFPL3 C22orf42 RFPL2 PIR46477
GH22F032042 0.9 FANTOM5 Ensembl ENCODE 5.1 -310.9 -310850 3.1 REST RFPL2 RFPL3 SLC5A1 SLC5A4 PIR57309
GH22F032656 0.7 FANTOM5 5.6 +301.9 301915 0.1 ZNF263 HLF SP2 CEBPB ZNF384 CEBPG ATF2 NFIL3 JUND ZNF692 RFPL2 TIMP3 ENSG00000229673 LL22NC03-104C7.1 RFPL3 SYN3 PIR38867
GH22F032626 1.3 FANTOM5 Ensembl ENCODE 2.9 +273.3 273344 4.5 SOX13 ELF3 CTCF ZNF175 CEBPG ZNF514 RAD21 RARA HNF4G SMC3 TIMP3 LL22NC03-104C7.1 ENSG00000229673 RFPL2 RFPL3 GC22P032635 LOC105373003
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RFPL3 on UCSC Golden Path with GeneCards custom track

Promoters for RFPL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000617179 -284 400 POLR2A NFE2

Genomic Location for RFPL3 Gene

32,354,885 bp from pter
32,361,161 bp from pter
6,277 bases
Plus strand

Genomic View for RFPL3 Gene

Genes around RFPL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL3 Gene

Proteins for RFPL3 Gene

  • Protein details for RFPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ret finger protein-like 3
    Protein Accession:
    Secondary Accessions:
    • A2A279
    • Q6IC03
    • Q6IC04
    • Q6NSX3
    • Q8N5R4

    Protein attributes for RFPL3 Gene

    317 amino acids
    Molecular mass:
    35386 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA09046.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RFPL3 Gene


neXtProt entry for RFPL3 Gene

Post-translational modifications for RFPL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL3 Gene

No data available for DME Specific Peptides for RFPL3 Gene

Domains & Families for RFPL3 Gene

Suggested Antigen Peptide Sequences for RFPL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL3: view

No data available for Gene Families for RFPL3 Gene

Function for RFPL3 Gene

Molecular function for RFPL3 Gene

GENATLAS Biochemistry:
ret finger protein-like 3,B box family

Gene Ontology (GO) - Molecular Function for RFPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RFPL3: view
genes like me logo Genes that share phenotypes with RFPL3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL3 Gene

Localization for RFPL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFPL3 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL3 Gene

Pathways & Interactions for RFPL3 Gene

SuperPathways for RFPL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for RFPL3 Gene

Transcripts for RFPL3 Gene

mRNA/cDNA for RFPL3 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL3 Gene

Ret finger protein-like 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL3 Gene

No ASD Table

Relevant External Links for RFPL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFPL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RFPL3 Gene

mRNA differential expression in normal tissues according to GTEx for RFPL3 Gene

This gene is overexpressed in Testis (x34.0) and Brain - Cerebellar Hemisphere (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of RFPL3 Gene:


SOURCE GeneReport for Unigene cluster for RFPL3 Gene:

genes like me logo Genes that share expression patterns with RFPL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RFPL3 Gene

Orthologs for RFPL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFPL3 34
  • 98.26 (n)
-- 35
  • 87 (a)
(Canis familiaris)
Mammalia -- 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 26 (a)
(Bos Taurus)
Mammalia -- 35
  • 25 (a)
(Mus musculus)
Mammalia Mefv 35
  • 5 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 13 (a)
Species where no ortholog for RFPL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL3 Gene

Gene Tree for RFPL3 (if available)
Gene Tree for RFPL3 (if available)

Paralogs for RFPL3 Gene

Paralogs for RFPL3 Gene

(14) SIMAP similar genes for RFPL3 Gene using alignment to 1 proteins: Pseudogenes for RFPL3 Gene

genes like me logo Genes that share paralogs with RFPL3: view

Variants for RFPL3 Gene

Sequence variations from dbSNP and Humsavar for RFPL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10427814 -- 32,355,086(+) GCATC(A/G)TTTAT intron-variant, upstream-variant-2KB
rs10427862 -- 32,355,257(+) gtaga(G/T)ctaga intron-variant, upstream-variant-2KB
rs11089557 -- 32,358,049(+) ACAAA(A/G)CTGGA intron-variant, utr-variant-5-prime
rs111744781 -- 32,361,430(+) TAAAA(C/T)TAATA intron-variant, downstream-variant-500B
rs111840961 -- 32,361,608(+) AATCA(A/G)GGACT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RFPL3 Gene

Variant ID Type Subtype PubMed ID
nsv979671 CNV duplication 23825009
nsv964624 CNV duplication 23825009
nsv588895 CNV gain 21841781
nsv459874 CNV gain 19166990
esv3893474 CNV gain 25118596
esv3575476 CNV gain 25503493
esv2422247 CNV duplication 17116639

Variation tolerance for RFPL3 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.32; 76.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFPL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL3 Gene

Disorders for RFPL3 Gene

Relevant External Links for RFPL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RFPL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL3 Gene

Publications for RFPL3 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E. … Dumanski J.P. (Genome Res. 1999) 2 3 4 22 64
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth. (PMID: 26318425) Qin Y. … Wu T. (Oncotarget 2015) 3 64

Products for RFPL3 Gene

Sources for RFPL3 Gene

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