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Aliases for RFPL2 Gene

Aliases for RFPL2 Gene

  • Ret Finger Protein-Like 2 2 3
  • RING Finger Protein 79 3 4
  • RNF79 3 4

External Ids for RFPL2 Gene

Previous GeneCards Identifiers for RFPL2 Gene

  • GC22M029282
  • GC22M030910
  • GC22M032586
  • GC22M015544

Summaries for RFPL2 Gene

GeneCards Summary for RFPL2 Gene

RFPL2 (Ret Finger Protein-Like 2) is a Protein Coding gene. An important paralog of this gene is RFPL4A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL2 Gene

Genomics for RFPL2 Gene

Regulatory Elements for RFPL2 Gene

Genomic Location for RFPL2 Gene

32,190,435 bp from pter
32,207,236 bp from pter
16,802 bases
Minus strand

Genomic View for RFPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL2 Gene

Proteins for RFPL2 Gene

  • Protein details for RFPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ret finger protein-like 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RFPL2 Gene

    378 amino acids
    Molecular mass:
    42077 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA09045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RFPL2 Gene


neXtProt entry for RFPL2 Gene

Proteomics data for RFPL2 Gene at MOPED

Post-translational modifications for RFPL2 Gene

No Post-translational modifications

Other Protein References for RFPL2 Gene

No data available for DME Specific Peptides for RFPL2 Gene

Domains for RFPL2 Gene

Gene Families for RFPL2 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for RFPL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75678
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL2: view

Function for RFPL2 Gene

Molecular function for RFPL2 Gene

GENATLAS Biochemistry:
ret finger protein-like 2,B box family

Gene Ontology (GO) - Molecular Function for RFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RFPL2: view

Phenotypes for RFPL2 Gene

GenomeRNAi human phenotypes for RFPL2:
genes like me logo Genes that share phenotypes with RFPL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFPL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RFPL2 Gene

Localization for RFPL2 Gene

Subcellular locations from

Jensen Localization Image for RFPL2 Gene COMPARTMENTS Subcellular localization image for RFPL2 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL2 Gene

Pathways for RFPL2 Gene

SuperPathways for RFPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL2 Gene


No data available for Pathways by source for RFPL2 Gene

Transcripts for RFPL2 Gene

mRNA/cDNA for RFPL2 Gene

Unigene Clusters for RFPL2 Gene

Ret finger protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFPL2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL2 Gene

No ASD Table

Relevant External Links for RFPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFPL2 Gene

mRNA expression in normal human tissues for RFPL2 Gene

mRNA differential expression in normal tissues according to GTEx for RFPL2 Gene

This gene is overexpressed in Brain - Cortex (7.6), Brain - Frontal Cortex (BA9) (7.5), Prostate (4.6), and Brain - Putamen (basal ganglia) (4.1).

Protein differential expression in normal tissues for RFPL2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RFPL2 Gene

SOURCE GeneReport for Unigene cluster for RFPL2 Gene Hs.157427

mRNA Expression by UniProt/SwissProt for RFPL2 Gene

Tissue specificity: Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney
genes like me logo Genes that share expressions with RFPL2: view

Expression partners for RFPL2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RFPL2 Gene

Orthologs for RFPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFPL2 35
  • 98.24 (n)
  • 96.3 (a)
-- 36
  • 80 (a)
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 19 (a)
Species with no ortholog for RFPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL2 Gene

Gene Tree for RFPL2 (if available)
Gene Tree for RFPL2 (if available)

Paralogs for RFPL2 Gene

Paralogs for RFPL2 Gene

Selected SIMAP similar genes for RFPL2 Gene using alignment to 2 proteins: Pseudogenes for RFPL2 Gene

genes like me logo Genes that share paralogs with RFPL2: view

Variants for RFPL2 Gene

Sequence variations from dbSNP and Humsavar for RFPL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs108211 -- 32,194,462(+) GTCAC(A/G)CCCTT reference, missense, intron-variant, upstream-variant-2KB
rs125961 -- 32,189,990(+) ATTAA(C/T)TGGGG downstream-variant-500B
rs125962 -- 32,190,003(+) AGTTA(C/T)CATTG downstream-variant-500B
rs125964 -- 32,194,146(+) TGGAA(A/G)TGAAT intron-variant, upstream-variant-2KB
rs136464 -- 32,190,279(+) CGACG(C/T)GGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RFPL2 Gene

Variant ID Type Subtype PubMed ID
nsv834177 CNV Gain 17160897
esv2422247 CNV Duplication 17116639
nsv834178 CNV Loss 17160897
nsv459874 CNV Gain 19166990
nsv3597 CNV Loss 18451855

Relevant External Links for RFPL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL2 Gene

Disorders for RFPL2 Gene

No disorders were found for RFPL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RFPL2 Gene

Publications for RFPL2 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E. … Dumanski J.P. (Genome Res. 1999) 2 3 4 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RFPL2 Gene

Sources for RFPL2 Gene

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