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Aliases for RFPL2 Gene

Aliases for RFPL2 Gene

  • Ret Finger Protein Like 2 2 3
  • RING Finger Protein 79 3 4
  • RNF79 3 4
  • Ret Finger Protein-Like 2 5

External Ids for RFPL2 Gene

Previous GeneCards Identifiers for RFPL2 Gene

  • GC22M029282
  • GC22M030910
  • GC22M032586
  • GC22M015544

Summaries for RFPL2 Gene

GeneCards Summary for RFPL2 Gene

RFPL2 (Ret Finger Protein Like 2) is a Protein Coding gene. An important paralog of this gene is RFPL4A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL2 Gene

Genomics for RFPL2 Gene

Regulatory Elements for RFPL2 Gene

Genomic Location for RFPL2 Gene

Chromosome:
22
Start:
32,190,435 bp from pter
End:
32,207,236 bp from pter
Size:
16,802 bases
Orientation:
Minus strand

Genomic View for RFPL2 Gene

Genes around RFPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL2 Gene

Proteins for RFPL2 Gene

  • Protein details for RFPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75678-RFPL2_HUMAN
    Recommended name:
    Ret finger protein-like 2
    Protein Accession:
    O75678

    Protein attributes for RFPL2 Gene

    Size:
    378 amino acids
    Molecular mass:
    42077 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA09045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RFPL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFPL2 Gene

Proteomics data for RFPL2 Gene at MOPED

Post-translational modifications for RFPL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RFPL2 Gene

Domains & Families for RFPL2 Gene

Gene Families for RFPL2 Gene

Suggested Antigen Peptide Sequences for RFPL2 Gene

Graphical View of Domain Structure for InterPro Entry

O75678

UniProtKB/Swiss-Prot:

RFPL2_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL2: view

Function for RFPL2 Gene

Molecular function for RFPL2 Gene

GENATLAS Biochemistry:
ret finger protein-like 2,B box family

Gene Ontology (GO) - Molecular Function for RFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RFPL2: view
genes like me logo Genes that share phenotypes with RFPL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RFPL2

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL2 Gene

Localization for RFPL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFPL2 Gene COMPARTMENTS Subcellular localization image for RFPL2 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL2 Gene

Pathways & Interactions for RFPL2 Gene

SuperPathways for RFPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RFPL2 Gene

Drugs & Compounds for RFPL2 Gene

No Compound Related Data Available

Transcripts for RFPL2 Gene

Unigene Clusters for RFPL2 Gene

Ret finger protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL2 Gene

No ASD Table

Relevant External Links for RFPL2 Gene

GeneLoc Exon Structure for
RFPL2
ECgene alternative splicing isoforms for
RFPL2

Expression for RFPL2 Gene

mRNA expression in normal human tissues for RFPL2 Gene

mRNA differential expression in normal tissues according to GTEx for RFPL2 Gene

This gene is overexpressed in Brain - Cortex (x7.6), Brain - Frontal Cortex (BA9) (x7.5), Prostate (x4.6), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for RFPL2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RFPL2 Gene



SOURCE GeneReport for Unigene cluster for RFPL2 Gene Hs.157427

mRNA Expression by UniProt/SwissProt for RFPL2 Gene

O75678-RFPL2_HUMAN
Tissue specificity: Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.
genes like me logo Genes that share expression patterns with RFPL2: view

Protein tissue co-expression partners for RFPL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RFPL2 Gene

Orthologs for RFPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFPL2 35
  • 98.24 (n)
  • 96.3 (a)
-- 36
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 19 (a)
ManyToMany
Species with no ortholog for RFPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL2 Gene

ENSEMBL:
Gene Tree for RFPL2 (if available)
TreeFam:
Gene Tree for RFPL2 (if available)

Paralogs for RFPL2 Gene

Paralogs for RFPL2 Gene

(10) SIMAP similar genes for RFPL2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RFPL2 Gene

genes like me logo Genes that share paralogs with RFPL2: view

Variants for RFPL2 Gene

Sequence variations from dbSNP and Humsavar for RFPL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs8135276 - 32,193,103(+) GACGG(C/T)GCATC reference, missense
rs136478 - 32,193,036(+) AAGAG(C/T)AACAG reference, missense
VAR_060536 -
VAR_060537 -
VAR_060538 -

Structural Variations from Database of Genomic Variants (DGV) for RFPL2 Gene

Variant ID Type Subtype PubMed ID
nsv834177 CNV Gain 17160897
esv2422247 CNV Duplication 17116639
nsv834178 CNV Loss 17160897
nsv459874 CNV Gain 19166990
nsv3597 CNV Loss 18451855

Variation tolerance for RFPL2 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.82; 97.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFPL2 Gene

HapMap Linkage Disequilibrium report
RFPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL2 Gene

Disorders for RFPL2 Gene

Relevant External Links for RFPL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFPL2

No disorders were found for RFPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL2 Gene

Publications for RFPL2 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E. … Dumanski J.P. (Genome Res. 1999) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. (PMID: 18656177) Bonnefont J. … Krause K.H. (Am. J. Hum. Genet. 2008) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3

Products for RFPL2 Gene

Sources for RFPL2 Gene

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