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Aliases for RFPL2 Gene

Aliases for RFPL2 Gene

  • Ret Finger Protein Like 2 2 3 5
  • RING Finger Protein 79 3 4
  • RNF79 3 4
  • Ret Finger Protein-Like 2 3

External Ids for RFPL2 Gene

Previous GeneCards Identifiers for RFPL2 Gene

  • GC22M029282
  • GC22M030910
  • GC22M032586
  • GC22M015544

Summaries for RFPL2 Gene

GeneCards Summary for RFPL2 Gene

RFPL2 (Ret Finger Protein Like 2) is a Protein Coding gene. An important paralog of this gene is RFPL3.

Additional gene information for RFPL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL2 Gene

Genomics for RFPL2 Gene

GeneHancer (GH) Regulatory Elements for RFPL2 Gene

Promoters and enhancers for RFPL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I032202 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 555.3 +4.3 4263 1.3 CTCF SUZ12 ARID4B ZIC2 ZNF48 RAD21 YY1 ZFHX2 GLIS2 PATZ1 RFPL2 IGLCOR22-1 SLC5A4-AS1
GH22I032206 Enhancer 0.8 Ensembl ENCODE 556.8 +0.3 263 1.4 HDGF CTCF ZNF654 ZNF521 ZBTB6 ZNF133 RAD21 GATA3 ZNF776 ZNF580 RFPL2 SLC5A4-AS1 PRR14L DEPDC5 SFI1 CPSF1P1
GH22I032042 Promoter/Enhancer 1.2 EPDnew FANTOM5 ENCODE dbSUPER 19.5 +163.2 163200 3.1 REST SLC5A1 RFPL2 RFPL3 SLC5A4 PIR57309
GH22I031927 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 12.6 +280.1 280091 0.3 MXI1 RFX1 NFYC BMI1 RFX5 GATA3 GATA2 POLR2A RFX3 ZNF341 RFPL2 RNU6-201P DEPDC5 YWHAH EIF4ENIF1 C22orf24 ENSG00000227813
GH22I032410 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 3.9 -204.3 -204312 2.8 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ZNF207 ZNF143 FOS RUNX3 RTCB LOC100422292 FBXO7 ENSG00000241954 RFPL3S IGLVIVOR22-2 LOC339666 BPIFC RFPL2 RFPL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RFPL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RFPL2 gene promoter:

Genomic Locations for RFPL2 Gene

Genomic Locations for RFPL2 Gene
chr22:32,190,435-32,207,236
(GRCh38/hg38)
Size:
16,802 bases
Orientation:
Minus strand
chr22:32,586,422-32,600,718
(GRCh37/hg19)

Genomic View for RFPL2 Gene

Genes around RFPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL2 Gene

Proteins for RFPL2 Gene

  • Protein details for RFPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75678-RFPL2_HUMAN
    Recommended name:
    Ret finger protein-like 2
    Protein Accession:
    O75678

    Protein attributes for RFPL2 Gene

    Size:
    378 amino acids
    Molecular mass:
    42077 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA09045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RFPL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFPL2 Gene

Post-translational modifications for RFPL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RFPL2 Gene

Domains & Families for RFPL2 Gene

Gene Families for RFPL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RFPL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RFPL2: view

No data available for UniProtKB/Swiss-Prot for RFPL2 Gene

Function for RFPL2 Gene

Molecular function for RFPL2 Gene

GENATLAS Biochemistry:
ret finger protein-like 2,B box family

Phenotypes From GWAS Catalog for RFPL2 Gene

Gene Ontology (GO) - Molecular Function for RFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RFPL2: view
genes like me logo Genes that share phenotypes with RFPL2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL2 Gene

Localization for RFPL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFPL2 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL2 Gene

Pathways & Interactions for RFPL2 Gene

SuperPathways for RFPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RFPL2 Gene

Drugs & Compounds for RFPL2 Gene

No Compound Related Data Available

Transcripts for RFPL2 Gene

Unigene Clusters for RFPL2 Gene

Ret finger protein-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL2 Gene

No ASD Table

Relevant External Links for RFPL2 Gene

GeneLoc Exon Structure for
RFPL2
ECgene alternative splicing isoforms for
RFPL2

Expression for RFPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RFPL2 Gene

mRNA differential expression in normal tissues according to GTEx for RFPL2 Gene

This gene is overexpressed in Brain - Cortex (x7.6), Brain - Frontal Cortex (BA9) (x7.5), Prostate (x4.6), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for RFPL2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RFPL2 Gene



Protein tissue co-expression partners for RFPL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RFPL2 Gene:

RFPL2

SOURCE GeneReport for Unigene cluster for RFPL2 Gene:

Hs.157427

mRNA Expression by UniProt/SwissProt for RFPL2 Gene:

O75678-RFPL2_HUMAN
Tissue specificity: Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Evidence on tissue expression from TISSUES for RFPL2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RFPL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFPL2 Gene

Orthologs for RFPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFPL2 33
  • 98.24 (n)
-- 34
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 19 (a)
ManyToMany
Species where no ortholog for RFPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL2 Gene

ENSEMBL:
Gene Tree for RFPL2 (if available)
TreeFam:
Gene Tree for RFPL2 (if available)

Paralogs for RFPL2 Gene

Paralogs for RFPL2 Gene

(10) SIMAP similar genes for RFPL2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RFPL2 Gene

genes like me logo Genes that share paralogs with RFPL2: view

Variants for RFPL2 Gene

Sequence variations from dbSNP and Humsavar for RFPL2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000461985 -- 32,195,355(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000614537 -- 32,206,259(-) T/A upstream_transcript_variant
rs1000735980 -- 32,205,012(-) G/A upstream_transcript_variant
rs1000745025 -- 32,199,517(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000773034 -- 32,206,457(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RFPL2 Gene

Variant ID Type Subtype PubMed ID
esv2422247 CNV duplication 17116639
esv3568364 CNV loss 25503493
esv3575476 CNV gain 25503493
esv3893474 CNV gain 25118596
nsv3597 CNV deletion 18451855
nsv459874 CNV gain 19166990
nsv588895 CNV gain 21841781
nsv834177 CNV gain 17160897
nsv834178 CNV loss 17160897
nsv953071 CNV deletion 24416366
nsv966105 CNV duplication 23825009

Variation tolerance for RFPL2 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.82; 97.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RFPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RFPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL2 Gene

Disorders for RFPL2 Gene

Additional Disease Information for RFPL2

No disorders were found for RFPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL2 Gene

Publications for RFPL2 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E … Dumanski JP (Genome research 1999) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58

Products for RFPL2 Gene

Sources for RFPL2 Gene

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