Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RFPL2 Gene

Aliases for RFPL2 Gene

  • Ret Finger Protein Like 2 2 3 5
  • RING Finger Protein 79 3 4
  • RNF79 3 4
  • Ret Finger Protein-Like 2 3

External Ids for RFPL2 Gene

Previous GeneCards Identifiers for RFPL2 Gene

  • GC22M029282
  • GC22M030910
  • GC22M032586
  • GC22M015544

Summaries for RFPL2 Gene

GeneCards Summary for RFPL2 Gene

RFPL2 (Ret Finger Protein Like 2) is a Protein Coding gene. An important paralog of this gene is RFPL3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL2 Gene

Genomics for RFPL2 Gene

Regulatory Elements for RFPL2 Gene

Enhancers for RFPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G032042 0.9 FANTOM5 ENCODE dbSUPER 19.5 +163.2 163201 3.1 REST RFPL2 RFPL3 SLC5A1 SLC5A4 PIR57309
GH22G031927 1.3 FANTOM5 ENCODE dbSUPER 12.6 +280.1 280091 0.3 MXI1 RFX1 NFYC BMI1 EP300 RFX5 GATA3 RFX3 GATA2 NFYB RFPL2 RNU6-201P DEPDC5 YWHAH EIF4ENIF1 ENSG00000227813
GH22G032656 0.7 FANTOM5 20.1 -449.6 -449564 0.1 MXI1 CEBPG ZNF384 ZNF652 ZBTB20 ZNF263 HLF CEBPB SP2 ATF2 RFPL2 TIMP3 ENSG00000229673 LL22NC03-104C7.1 RFPL3 SYN3 PIR38867
GH22G032089 0.4 FANTOM5 21.5 +117.8 117848 0.1 MAFK RFPL2 SLC5A1 IGLCOR22-1 SLC5A4-AS1 SLC5A4 FBXO7 RFPL3 PIR57309
GH22G032206 1 Ensembl ENCODE 6.7 +0.3 264 1.4 HDGF CTCF TAL1 ZNF133 RAD21 TCF12 ZNF776 GATA3 NCOR1 HNF4G PRR14L RFPL2 CPSF1P1 SLC5A4-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RFPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RFPL2 Gene

Chromosome:
22
Start:
32,190,435 bp from pter
End:
32,207,236 bp from pter
Size:
16,802 bases
Orientation:
Minus strand

Genomic View for RFPL2 Gene

Genes around RFPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL2 Gene

Proteins for RFPL2 Gene

  • Protein details for RFPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75678-RFPL2_HUMAN
    Recommended name:
    Ret finger protein-like 2
    Protein Accession:
    O75678

    Protein attributes for RFPL2 Gene

    Size:
    378 amino acids
    Molecular mass:
    42077 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA09045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RFPL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFPL2 Gene

Post-translational modifications for RFPL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RFPL2 Gene

Domains & Families for RFPL2 Gene

Gene Families for RFPL2 Gene

Suggested Antigen Peptide Sequences for RFPL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RFPL2: view

No data available for UniProtKB/Swiss-Prot for RFPL2 Gene

Function for RFPL2 Gene

Molecular function for RFPL2 Gene

GENATLAS Biochemistry:
ret finger protein-like 2,B box family

Gene Ontology (GO) - Molecular Function for RFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RFPL2: view
genes like me logo Genes that share phenotypes with RFPL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL2 Gene

Localization for RFPL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFPL2 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL2 Gene

Pathways & Interactions for RFPL2 Gene

SuperPathways for RFPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RFPL2 Gene

Drugs & Compounds for RFPL2 Gene

No Compound Related Data Available

Transcripts for RFPL2 Gene

Unigene Clusters for RFPL2 Gene

Ret finger protein-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL2 Gene

No ASD Table

Relevant External Links for RFPL2 Gene

GeneLoc Exon Structure for
RFPL2
ECgene alternative splicing isoforms for
RFPL2

Expression for RFPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RFPL2 Gene

mRNA differential expression in normal tissues according to GTEx for RFPL2 Gene

This gene is overexpressed in Brain - Cortex (x7.6), Brain - Frontal Cortex (BA9) (x7.5), Prostate (x4.6), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for RFPL2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RFPL2 Gene



Protein tissue co-expression partners for RFPL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RFPL2 Gene:

RFPL2

SOURCE GeneReport for Unigene cluster for RFPL2 Gene:

Hs.157427

mRNA Expression by UniProt/SwissProt for RFPL2 Gene:

O75678-RFPL2_HUMAN
Tissue specificity: Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Evidence on tissue expression from TISSUES for RFPL2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RFPL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFPL2 Gene

Orthologs for RFPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFPL2 34
  • 98.24 (n)
-- 35
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 19 (a)
ManyToMany
Species where no ortholog for RFPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL2 Gene

ENSEMBL:
Gene Tree for RFPL2 (if available)
TreeFam:
Gene Tree for RFPL2 (if available)

Paralogs for RFPL2 Gene

Paralogs for RFPL2 Gene

(10) SIMAP similar genes for RFPL2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RFPL2 Gene

genes like me logo Genes that share paralogs with RFPL2: view

Variants for RFPL2 Gene

Sequence variations from dbSNP and Humsavar for RFPL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000461985 -- 32,195,355(+) GACAT(A/G)TAATA intron-variant, upstream-variant-2KB
rs1000614537 -- 32,206,259(+) GCAGG(A/T)AGGGG upstream-variant-2KB
rs1000735980 -- 32,205,012(+) ATAAA(A/G)GATGC upstream-variant-2KB
rs1000745025 -- 32,199,517(+) ACTCA(C/T)TCTCT intron-variant
rs1000773034 -- 32,206,457(+) GCGGG(A/T)GCCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RFPL2 Gene

Variant ID Type Subtype PubMed ID
esv2422247 CNV duplication 17116639
esv3568364 CNV loss 25503493
esv3575476 CNV gain 25503493
esv3893474 CNV gain 25118596
nsv3597 CNV deletion 18451855
nsv459874 CNV gain 19166990
nsv588895 CNV gain 21841781
nsv834177 CNV gain 17160897
nsv834178 CNV loss 17160897
nsv953071 CNV deletion 24416366
nsv966105 CNV duplication 23825009

Variation tolerance for RFPL2 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.82; 97.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RFPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL2 Gene

Disorders for RFPL2 Gene

Relevant External Links for RFPL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFPL2

No disorders were found for RFPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL2 Gene

Publications for RFPL2 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E. … Dumanski J.P. (Genome Res. 1999) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64

Products for RFPL2 Gene

Sources for RFPL2 Gene

Content
Loading form....