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Aliases for RFPL1 Gene

Aliases for RFPL1 Gene

  • Ret Finger Protein-Like 1 2 3
  • RING Finger Protein 78 3 4
  • RNF78 3 4
  • RFPL1L 4

External Ids for RFPL1 Gene

Previous GeneCards Identifiers for RFPL1 Gene

  • GC22P026530
  • GC22P028159
  • GC22P028153
  • GC22P028164
  • GC22P029834

Summaries for RFPL1 Gene

GeneCards Summary for RFPL1 Gene

RFPL1 (Ret Finger Protein-Like 1) is a Protein Coding gene. An important paralog of this gene is RFPL4A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL1 Gene

Genomics for RFPL1 Gene

Regulatory Elements for RFPL1 Gene

Genomic Location for RFPL1 Gene

Start:
29,438,583 bp from pter
End:
29,442,455 bp from pter
Size:
3,873 bases
Orientation:
Plus strand

Genomic View for RFPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL1 Gene

Proteins for RFPL1 Gene

  • Protein details for RFPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75677-RFPL1_HUMAN
    Recommended name:
    Ret finger protein-like 1
    Protein Accession:
    O75677
    Secondary Accessions:
    • Q6IC06
    • Q9UJ97

    Protein attributes for RFPL1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35491 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA09043.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA09044.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RFPL1 Gene

Proteomics data for RFPL1 Gene at MOPED

Post-translational modifications for RFPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RFPL1 Gene

Domains for RFPL1 Gene

Gene Families for RFPL1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for RFPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75677

UniProtKB/Swiss-Prot:

RFPL1_HUMAN :
  • O75677
Domain:
  • Contains 1 B30.2/SPRY domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RFPL1: view

Function for RFPL1 Gene

Molecular function for RFPL1 Gene

GENATLAS Biochemistry: ret finger protein-like 1,B box family

Gene Ontology (GO) - Molecular Function for RFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RFPL1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RFPL1 Gene

Localization for RFPL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFPL1 Gene COMPARTMENTS Subcellular localization image for RFPL1 gene
Compartment Confidence
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL1 Gene

Pathways for RFPL1 Gene

SuperPathways for RFPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL1 Gene

None

No data available for Pathways by source for RFPL1 Gene

Transcripts for RFPL1 Gene

mRNA/cDNA for RFPL1 Gene

(4) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL1 Gene

Ret finger protein-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RFPL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RFPL1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL1 Gene

No ASD Table

Relevant External Links for RFPL1 Gene

GeneLoc Exon Structure for
RFPL1
ECgene alternative splicing isoforms for
RFPL1

Expression for RFPL1 Gene

mRNA expression in normal human tissues for RFPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFPL1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.3), Brain - Anterior cingulate cortex (BA24) (6.7), Brain - Cortex (6.4), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RFPL1 Gene

SOURCE GeneReport for Unigene cluster for RFPL1 Gene Hs.648249

mRNA Expression by UniProt/SwissProt for RFPL1 Gene

O75677-RFPL1_HUMAN
Tissue specificity: Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney
genes like me logo Genes that share expressions with RFPL1: view

In Situ Assay Products

Orthologs for RFPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFPL1 36
  • 72 (a)
OneToOne
RFPL3 35
  • 95.72 (n)
  • 90.97 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for RFPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL1 Gene

ENSEMBL:
Gene Tree for RFPL1 (if available)
TreeFam:
Gene Tree for RFPL1 (if available)

Paralogs for RFPL1 Gene

Paralogs for RFPL1 Gene

Selected SIMAP similar genes for RFPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RFPL1: view

Variants for RFPL1 Gene

Sequence variations from dbSNP and Humsavar for RFPL1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
VAR_020115 -
VAR_039572 -

Relevant External Links for RFPL1 Gene

HapMap Linkage Disequilibrium report
RFPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RFPL1 Gene

Disorders for RFPL1 Gene

Relevant External Links for RFPL1

Genetic Association Database (GAD)
RFPL1
genes like me logo Genes that share disorders with RFPL1: view

No data available for UniProtKB/Swiss-Prot for RFPL1 Gene

Publications for RFPL1 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E. … Dumanski J.P. (Genome Res. 1999) 2 3 4 23
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  3. A genome-wide association study of carotid atherosclerosis in HIV-infected men. (PMID: 20009918) Shrestha S. … Grunfeld C. (AIDS 2010) 3 48
  4. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. (PMID: 20725088) Bonnefont J. … Krause K.H. (Cell Death Differ. 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for RFPL1 Gene

Sources for RFPL1 Gene

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