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Aliases for RFPL1 Gene

Aliases for RFPL1 Gene

  • Ret Finger Protein Like 1 2 3 5
  • RING Finger Protein 78 3 4
  • RNF78 3 4
  • Ret Finger Protein-Like 1 3
  • RFPL1L 4

External Ids for RFPL1 Gene

Previous GeneCards Identifiers for RFPL1 Gene

  • GC22P026530
  • GC22P028159
  • GC22P028153
  • GC22P028164
  • GC22P029834

Summaries for RFPL1 Gene

GeneCards Summary for RFPL1 Gene

RFPL1 (Ret Finger Protein Like 1) is a Protein Coding gene. An important paralog of this gene is RFPL3.

Additional gene information for RFPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFPL1 Gene

Genomics for RFPL1 Gene

GeneHancer (GH) Regulatory Elements for RFPL1 Gene

Promoters and enhancers for RFPL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I029479 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 11.9 +46.2 46166 4.5 ATF1 SIN3A ZNF766 GLIS2 ZNF143 ATF7 SP3 NCOA1 MIER2 REST NEFH ENSG00000282816 THOC5 RFPL1 RNF215 RASL10A EWSR1 NIPSNAP1
GH22I029469 Enhancer 1.1 Ensembl ENCODE 12.7 +35.9 35931 1.3 PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZNF48 ETS1 GLIS2 ZNF143 KLF7 RFPL1 THOC5 RFPL1S NIPSNAP1 PIR46787
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RFPL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RFPL1 gene promoter:

Genomic Locations for RFPL1 Gene

Genomic Locations for RFPL1 Gene
7,926 bases
Plus strand

Genomic View for RFPL1 Gene

Genes around RFPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL1 Gene

Proteins for RFPL1 Gene

  • Protein details for RFPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ret finger protein-like 1
    Protein Accession:
    Secondary Accessions:
    • Q6IC06
    • Q9UJ97

    Protein attributes for RFPL1 Gene

    317 amino acids
    Molecular mass:
    35491 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA09043.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA09044.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RFPL1 Gene

Post-translational modifications for RFPL1 Gene

No Post-translational modifications

Other Protein References for RFPL1 Gene

No data available for DME Specific Peptides for RFPL1 Gene

Domains & Families for RFPL1 Gene

Gene Families for RFPL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RFPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RFPL1: view

No data available for UniProtKB/Swiss-Prot for RFPL1 Gene

Function for RFPL1 Gene

Molecular function for RFPL1 Gene

GENATLAS Biochemistry:
ret finger protein-like 1,B box family

Phenotypes From GWAS Catalog for RFPL1 Gene

Gene Ontology (GO) - Molecular Function for RFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RFPL1: view
genes like me logo Genes that share phenotypes with RFPL1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL1 Gene

Localization for RFPL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFPL1 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFPL1 Gene

Pathways & Interactions for RFPL1 Gene

SuperPathways for RFPL1 Gene

No Data Available

Interacting Proteins for RFPL1 Gene

Gene Ontology (GO) - Biological Process for RFPL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RFPL1 Gene

Drugs & Compounds for RFPL1 Gene

No Compound Related Data Available

Transcripts for RFPL1 Gene

mRNA/cDNA for RFPL1 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFPL1 Gene

Ret finger protein-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL1 Gene

No ASD Table

Relevant External Links for RFPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RFPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFPL1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.3), Brain - Anterior cingulate cortex (BA24) (x6.7), Brain - Cortex (x6.4), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RFPL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RFPL1 Gene:


SOURCE GeneReport for Unigene cluster for RFPL1 Gene:


mRNA Expression by UniProt/SwissProt for RFPL1 Gene:

Tissue specificity: Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Evidence on tissue expression from TISSUES for RFPL1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with RFPL1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFPL1 Gene

Orthologs for RFPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFPL3 33
  • 95.72 (n)
RFPL1 34
  • 72 (a)
(Canis familiaris)
Mammalia -- 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
Species where no ortholog for RFPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RFPL1 Gene

Gene Tree for RFPL1 (if available)
Gene Tree for RFPL1 (if available)

Paralogs for RFPL1 Gene

Paralogs for RFPL1 Gene

(15) SIMAP similar genes for RFPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RFPL1: view

Variants for RFPL1 Gene

Sequence variations from dbSNP and Humsavar for RFPL1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000256682 -- 29,417,340(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000409444 -- 29,411,499(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000493192 -- 29,417,636(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000569936 -- 29,433,495(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000744123 -- 29,439,404(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RFPL1 Gene

Variant ID Type Subtype PubMed ID
nsv1059994 CNV gain 25217958
nsv1060197 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv964618 CNV duplication 23825009
nsv979667 CNV duplication 23825009

Variation tolerance for RFPL1 Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.66; 97.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RFPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFPL1 Gene

Disorders for RFPL1 Gene

Additional Disease Information for RFPL1

No disorders were found for RFPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFPL1 Gene

Publications for RFPL1 Gene

  1. Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts. (PMID: 10508838) Seroussi E … Dumanski JP (Genome research 1999) 2 3 4 22 58
  2. A genome-wide association study of carotid atherosclerosis in HIV-infected men. (PMID: 20009918) Shrestha S … Grunfeld C (AIDS (London, England) 2010) 3 44 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for RFPL1 Gene

Sources for RFPL1 Gene

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