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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFPL1 Gene

protein-coding   GIFtS: 41
GCID: GC22P029834

Ret Finger Protein-Like 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ret Finger Protein-Like 11 2
RNF782 3
RING Finger Protein 782 3
RFPL1L3

External Ids:    HGNC: 99771   Entrez Gene: 59882   Ensembl: ENSG000001282507   OMIM: 6059685   UniProtKB: O756773   

Export aliases for RFPL1 gene to outside databases

Previous GC identifers: GC22P026530 GC22P028159 GC22P028153 GC22P028164


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RFPL1 Gene: 
RFPL1 (ret finger protein-like 1) is a protein-coding gene. Diseases associated with RFPL1 include prostatitis. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is MEFV.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFPL1 gene promoter:
         RFX1   AP-1   Lmo2   LCR-F1   GATA-1   ZID   GCNF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFPL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RFPL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12

RFPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFPL1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P029834:  view genomic region     (about GC identifiers)

Start:
29,834,572 bp from pter      End:
29,838,444 bp from pter
Size:
3,873 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RFPL1_HUMAN, O75677 (See protein sequence)
Recommended Name: Ret finger protein-like 1  
Size: 317 amino acids; 35491 Da
Sequence caution: Sequence=CAA09043.1; Type=Erroneous initiation; Sequence=CAA09044.1; Type=Erroneous initiation;
Secondary accessions: Q6IC06 Q9UJ97

Explore the universe of human proteins at neXtProt for RFPL1: NX_O75677

Explore proteomics data for RFPL1 at MOPED 

RFPL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RFPL1 Protein Expression

REFSEQ proteins: NP_066306.2  
ENSEMBL proteins: 
 ENSP00000346342  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNF: RING-type (C3HC4) zinc fingers

5/10 InterPro protein domains (see all 10):
 IPR001841 Znf_RING
 IPR001870 B30.2/SPRY
 IPR027370 zf-RING_LisH
 IPR013083 Znf_RING/FYVE/PHD
 IPR003879 Butyrophylin

Graphical View of Domain Structure for InterPro Entry O75677

ProtoNet protein and cluster: O75677

3 Blocks protein domains:
IPB001841 Zn-finger
IPB003879 Butyrophylin C-terminal DUF signature
IPB006574 SPRY-associated domain


UniProtKB/Swiss-Prot: RFPL1_HUMAN, O75677
Similarity: Contains 1 B30.2/SPRY domain
Similarity: Contains 1 RING-type zinc finger


RFPL1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for RFPL1:
ret finger protein-like 1,B box family

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
RFPL1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RFPL1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for RFPL1

Search CenterWatch for drugs/clinical trials and news about RFPL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RFPL1 gene: 
NM_021026.2  

Unigene Cluster for RFPL1:

Ret finger protein-like 1
Hs.648249
Unigene Representative Sequence: AJ010228
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000354373(uc003afn.3)
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Additional mRNA sequence: 

AJ010228.1 AJ010229.1 BC104768.1 CR456562.2 

2 DOTS entries:

DT.95159648  DT.101981224 

4 AceView cDNA sequences:

AJ010228 NM_021026 AJ010229 CR456562 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RFPL1 expression in normal human tissues (normalized intensities)      RFPL1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RFPL1 Expression
About this image


RFPL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
 
 Brain (Nervous System)

See RFPL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RFPL1

SOURCE GeneReport for Unigene cluster: Hs.648249

UniProtKB/Swiss-Prot: RFPL1_HUMAN, O75677
Tissue specificity: Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal
kidney

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFPL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RFPL1 gene from 2/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves ZNF7776
Uncharacterized protein
31(a)
possible ortholog
2(564030-564628)
zebrafish
(Danio rerio)
Actinopterygii btr306
bloodthirsty-related gene family, member 30
13(a)
possible ortholog
19(49825613-49832914)
        Species with no ortholog for RFPL1

ENSEMBL Gene Tree for RFPL1 (if available)
TreeFam Gene Tree for RFPL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RFPL1 gene
RFPL31 2  MEFV2  RFPL4AL12  RFPL4A2  RFPL22  RNF392  RFPL4B2  
15 SIMAP similar genes for RFPL1 using alignment to 1 protein entry:     RFPL1_HUMAN:
RFPL3    RFPL2    RFPL4A    RFPL4AL1    MEFV    TRIM26
TRIM27    RFPL4B    TRIM11    BT3.3    BTN3A3    TRIM21
BTN1A1    TRIM39    BTNL9

RFPL1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in RFPL1 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0201154
----see VAR_0201152 M T mis40--------
VAR_0395724
----see VAR_0395722 W R mis40--------

HapMap Linkage Disequilibrium report for RFPL1 (29834572 - 29838444 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for RFPL1: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing RFPL1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605968    OMIM disorders: --

2 diseases for RFPL1:    About MalaCards
prostatitis    


RFPL1 for disorders           About GeneDecksing

Genetic Association Database (GAD): RFPL1

Export disorders for RFPL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RFPL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RFPL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts. (PubMed id 10508838)1, 2, 3, 9 Seroussi E.... Dumanski J.P. (1999)
  2. A genome-wide association study of carotid atheroscle rosis in HIV-infected men. (PubMed id 20009918)1, 4 Shrestha S....Grunfeld C. (2010)
  3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
  4. Primate-specific RFPL1 gene controls cell-cycle progr ession through cyclin B1/Cdc2 degradation. (PubMed id 20725088)1 Bonnefont J....Krause K.H. (2011)
  5. Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. (PubMed id 18656177)1 Bonnefont J....Krause K.H. (2008)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Applying proteomic methodologies to analyze the effect of hexamethylene bisacetamide (HMBA) on proliferation and differentiation of human gastric carcinoma BGC-823 cells. (PubMed id 15147739)9 Zhang G....Peng X. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 5988 HGNC: 9977 AceView: RFPL1 Ensembl:ENSG00000128250 euGenes: HUgn5988
ECgene: RFPL1 H-InvDB: RFPL1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RFPL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RFPL1 gene:
Search GeneIP for patents involving RFPL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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Customized:
 lentivirus for stable overexpression of RFPL1
 lentivirus expression plasmids for stable overexpression of RFPL1
 adenovirus for overexpression of RFPL1
 Search LSBio for Antibodies for RFPL1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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