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RFNG Gene

protein-coding   GIFtS: 57
GCID: GC17M080005

RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase

(Previous names: radical fringe (Drosophila) homolog, radical fringe homolog...)
  Search for RFNG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase1 2     Radical Fringe Homolog (Drosophila)1
O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase2 3     Beta-1,3-N-Acetylglucosaminyltransferase Radical Fringe2
EC 2.4.1.2223 8     Radical Fringe Homolog2
Radical Fringe (Drosophila) Homolog1     

External Ids:    HGNC: 99741   Entrez Gene: 59862   Ensembl: ENSG000001697337   OMIM: 6025785   UniProtKB: Q9Y6443   
ORGUL members:    fRNAdb10:FR262209      
H-InvDB12:HIT000265771    
NCBI13:BC080181    
RNAdb15:HIV1178    

Export aliases for RFNG gene to outside databases

Previous GC identifers: GC17M079429 GC17M9J0047 GC17M080541 GC17M077599 GC17U900606 GC17M075405


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RFNG Gene:
RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) is a protein-coding gene. GO annotations related to this gene include O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LFNG.

UniProtKB/Swiss-Prot: RFNG_HUMAN, Q9Y644
Function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like
repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By
similarity)



fRNAdb sequence ontology for RFNG:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for RFNG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010663.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RFNG gene promoter:
         Max   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RFNG promoter sequence
   Search Chromatin IP Primers for RFNG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFNG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

RFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFNG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080005:  view genomic region     (about GC identifiers)

Start:
80,005,778 bp from pter      End:
80,009,707 bp from pter
Size:
3,930 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RFNG_HUMAN, Q9Y644 (See protein sequence)
Recommended Name: Beta-1,3-N-acetylglucosaminyltransferase radical fringe  
Size: 331 amino acids; 36424 Da
Cofactor: Manganese (By similarity)
Secondary accessions: O00588

Explore the universe of human proteins at neXtProt for RFNG: NX_Q9Y644

Explore proteomics data for RFNG at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn113
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RFNG (Q9Y644) (see all 11)
     DDDNYVN  RLPDDCT  FIAVKTT  LQQVTLS 


    See RFNG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002908.1  
    ENSEMBL proteins: 
     ENSP00000307971   ENSP00000402931   ENSP00000463623  
    Reactome Protein details: Q9Y644

    RFNG Human Recombinant Protein Products:

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    Novus Biologicals RFNG Protein
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    Cloud-Clone Corp. Proteins for RFNG

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases

    2 InterPro protein domains:
     IPR017374 Fringe
     IPR003378 Fringe-like

    Graphical View of Domain Structure for InterPro Entry Q9Y644

    ProtoNet protein and cluster: Q9Y644

    1 Blocks protein domain: IPB003378 Fringe-like

    UniProtKB/Swiss-Prot: RFNG_HUMAN, Q9Y644
    Similarity: Belongs to the glycosyltransferase 31 family


    Find genes that share domains with RFNG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFNG_HUMAN, Q9Y644
    Function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like
    repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By
    similarity)
    Catalytic activity: Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated
    protein acceptor

         Genatlas biochemistry entry for RFNG:
    radical fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH
    receptor genes for their specific ligands,essential mediator of somite segmentation and patterning

         Enzyme Number (IUBMB): EC 2.4.1.2221 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0033829O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with RFNG           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rfng):
     craniofacial  digestive/alimentary  embryogenesis  limbs/digits/tail  mortality/aging 
     normal  skeleton 

    Find genes that share phenotypes with RFNG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RFNG: Rfngtm2Tfv Rfngtm2.1Tfv Rfngtm1Grid

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RFNG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RFNG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFNG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFNG

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFNG_HUMAN, Q9Y644: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS10341080
    GO:0016020membrane ----
    GO:0030173integral component of Golgi membrane IEA--

    Find genes that share ontologies with RFNG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RFNG About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling0.30
    Notch Signaling Pathway0.84
    2Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Pre-NOTCH Processing in Golgi0.00
    3Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH0.64
    4Signaling by GPCR
    Signal Transduction0.58
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50


    Find genes that share SuperPaths with RFNG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RFNG
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RFNG
        Notch Signaling

    1 GeneGo (Thomson Reuters) Pathway for RFNG
        Development Notch Signaling Pathway

    1 BioSystems Pathway for RFNG
        Notch Signaling Pathway

    1 Reactome Pathway for RFNG
        Pre-NOTCH Processing in Golgi


    2 Kegg Pathways  (Kegg details for RFNG):
        Other types of O-glycan biosynthesis
    Notch signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including RFNG: 
              Notch Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RFNG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for RFNG (ENSP000003079714) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235396ENSP000004106744STRING: ENSP00000410674
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    NOTCH3ENSP000002633884STRING: ENSP00000263388
    LHX9ENSP000003563574STRING: ENSP00000356357
    LMO1ENSP000003382074STRING: ENSP00000338207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007389pattern specification process IEA--
    GO:0007399nervous system development IEA--
    GO:0009887organ morphogenesis NAS10341080
    GO:0030154cell differentiation IEA--
    GO:0032092positive regulation of protein binding IEA--

    Find genes that share ontologies with RFNG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFNG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for RFNG gene: 
    NM_002917.1  

    Unigene Cluster for RFNG:

    RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    Hs.569700  [show with all ESTs]
    Unigene Representative Sequence: BC146805
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580793(uc002kdh.3) ENST00000583784(uc021ufl.1) ENST00000310496(uc002kdj.3)
    ENST00000582478 ENST00000580953 ENST00000578676 ENST00000429557 ENST00000584838
    ENST00000580928 ENST00000584515 ENST00000578356 ENST00000584463
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RFNG (NM_002917)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFNG
      QuantiTect SYBR Green Assays in human, mouse, rat RFNG
      QuantiFast Probe-based Assays in human, mouse, rat RFNG

    Additional mRNA sequence: 

    AF038196.1 AK094016.1 AK293568.1 AK302068.1 BC014495.1 BC050399.1 BC069034.1 BC080181.1 
    BC146805.1 U94353.1 

    13 DOTS entries:

    DT.97845070  DT.100710916  DT.114386  DT.100713885  DT.100657159  DT.100814147  DT.100814151  DT.97836723 
    DT.86838582  DT.86853991  DT.100814150  DT.91854062  DT.95168504 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RFNG (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                          -     -     -                 -     -     -                             -                                                   
    SP2:                                                                                                  -                                                   
    SP3:                                                        -     -     -                             -                                                   
    SP4:                                                        -     -     -                                                                                 
    SP5:                                                        -     -     -                             -                                                   


    ECgene alternative splicing isoforms for RFNG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RFNG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGAAATG
    RFNG Expression
    About this image


    RFNG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Cerebral Cortex
             Septum   
    RFNG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFNG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.569700
        Pathway & Disease-focused RT2 Profiler PCR Array including RFNG: 
              Notch Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFNG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RFNG gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfng1 , 5 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase1, 5 83.15(n)1
    86.72(a)1
      11 (84.53 cM)5
    197191  NM_009053.21  NP_033079.11 
     1207807465 
    chicken
    (Gallus gallus)
    Aves RFNG1 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 72.2(n)
    77.12(a)
      395789  NM_204947.1  NP_990278.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFNG6
    RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminylt...
    44(a)
    1 ↔ 1
    2(118178712-118188604)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rfng1 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 67.04(n)
    68.89(a)
      100486895  XM_002937310.2  XP_002937356.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rfng1 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 70.71(n)
    73.48(a)
      414848  NM_001045336.1  NP_001038801.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fng1 fringe 56.15(n)
    49.81(a)
      40314  NM_079467.3  NP_524191.1 


    ENSEMBL Gene Tree for RFNG (if available)
    TreeFam Gene Tree for RFNG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RFNG gene
    LFNG2  MFNG2  
    2 SIMAP similar genes for RFNG using alignment to 5 protein entries:     RFNG_HUMAN (see all proteins):
    LFNG    MFNG

    Find genes that share paralogs with RFNG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RFNG (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380773511,2
    C--80005281(+) TCCACA/GCGCGT 1 -- ds50010--------
    rs1807151271,2
    --80005285(+) CGCGCA/GTTATG 1 -- ds50010--------
    rs1873884691,2
    --80005343(+) ACCCAC/TGCACG 1 -- ds50010--------
    rs1918638441,2
    --80005419(+) ATGCAC/TGTACA 1 -- ds50010--------
    rs1434323581,2
    --80005420(+) TGCACA/GTACAC 1 -- ds50010--------
    rs1837252581,2
    --80005439(+) TCAATA/GTGTCC 1 -- ds50010--------
    rs342644661,2
    C,F--80005462(+) GTACAC/TGCCCA 1 -- ds50013Minor allele frequency- T:0.33NA 6
    rs110779651,2
    C,F,A,H--80005463(+) TACACG/ACCCAC 1 -- ds50019Minor allele frequency- A:0.28NA WA CSA EA 370
    rs1904226741,2
    --80005469(+) CCCACA/GCACAC 1 -- ds50010--------
    rs99123771,2
    C,F--80005477(+) CACCCA/GCCCTC 1 -- ds50011Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for RFNG (80005778 - 80009707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RFNG (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3353n71CNV Loss21882294
    dgv3351n71CNV Loss21882294
    nsv909188CNV Loss21882294
    nsv909134CNV Loss21882294
    dgv3350n71CNV Loss21882294
    nsv909186CNV Loss21882294
    dgv3349n71CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3352n71CNV Loss21882294
    dgv3333n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602578OMIM information: 215500 601202 601251 605809 606579 607464 608631 609432 610185    
    1 disease from the University of Copenhagen DISEASES database for RFNG:
    Alagille syndrome

    Find genes that share disorders with RFNG           About GenesLikeMe


    Export disorders for RFNG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFNG gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RFNG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PubMed id 9187150)1, 2, 3 Johnston S.H....Vogt T.F. (Development 1997)
    2. Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes. (PubMed id 10341080)1, 2 Moran J.L....Vogt T.F. (Mamm. Genome 1999)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Radical fringe negatively modulates Notch signaling in postmitotic neurons of the rat brain. (PubMed id 11165380)1 Mikami T....Itoh N. (Brain Res. Mol. Brain Res. 2001)
    7. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
    8. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    9. (PubMed id 15103394)10 
    10. (PubMed id 18089548)10 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5986 HGNC: 9974 Ensembl:ENSG00000169733 euGenes: HUgn5986 ECgene: RFNG Kegg: 5986
    H-InvDB: RFNG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RFNG Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=RFNG

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RFNG gene:
    Search GeneIP for patents involving RFNG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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