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Aliases for RFNG Gene

Aliases for RFNG Gene

  • RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 2 3
  • EC 2.4.1.222 4 64
  • O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 4
  • Radical Fringe (Drosophila) Homolog 2
  • Radical Fringe Homolog (Drosophila) 2

External Ids for RFNG Gene

Summaries for RFNG Gene

GeneCards Summary for RFNG Gene

RFNG (RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by NOTCH1 PEST Domain Mutants in Cancer. GO annotations related to this gene include O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MFNG.

UniProtKB/Swiss-Prot for RFNG Gene

  • Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFNG Gene

Genomics for RFNG Gene

Genomic Location for RFNG Gene

Start:
82,047,902 bp from pter
End:
82,051,831 bp from pter
Size:
3,930 bases
Orientation:
Minus strand

Genomic View for RFNG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFNG Gene

Regulatory Elements for RFNG Gene

Proteins for RFNG Gene

  • Protein details for RFNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y644-RFNG_HUMAN
    Recommended name:
    Beta-1,3-N-acetylglucosaminyltransferase radical fringe
    Protein Accession:
    Q9Y644
    Secondary Accessions:
    • O00588

    Protein attributes for RFNG Gene

    Size:
    331 amino acids
    Molecular mass:
    36424 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for RFNG Gene

Proteomics data for RFNG Gene at MOPED

Post-translational modifications for RFNG Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn113

Other Protein References for RFNG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for RFNG Gene

Gene Families for RFNG Gene

HGNC:
  • B3GT :Beta 3-glycosyltransferases

Protein Domains for RFNG Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RFNG_HUMAN
Family:
  • Belongs to the glycosyltransferase 31 family.:
    • Q9Y644
genes like me logo Genes that share domains with RFNG: view

Function for RFNG Gene

Molecular function for RFNG Gene

GENATLAS Biochemistry: radical fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH receptor genes for their specific ligands,essential mediator of somite segmentation and patterning
UniProtKB/Swiss-Prot CatalyticActivity: Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
UniProtKB/Swiss-Prot Function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity).

Enzyme Numbers (IUBMB) for RFNG Gene

Gene Ontology (GO) - Molecular Function for RFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RFNG: view
genes like me logo Genes that share phenotypes with RFNG: view

Animal Models for RFNG Gene

MGI Knock Outs for RFNG:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for RFNG Gene

Localization for RFNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFNG Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFNG Gene COMPARTMENTS Subcellular localization image for RFNG gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 10341080
GO:0016020 membrane --
GO:0030173 integral component of Golgi membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RFNG: view

Pathways for RFNG Gene

genes like me logo Genes that share pathways with RFNG: view

Pathways by source for RFNG Gene

1 R&D Systems pathway for RFNG Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RFNG Gene
1 Qiagen pathway for RFNG Gene

Gene Ontology (GO) - Biological Process for RFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007389 pattern specification process IEA --
GO:0007399 nervous system development IEA --
GO:0008152 metabolic process IEA --
GO:0009887 organ morphogenesis NAS 10341080
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RFNG: view

Transcripts for RFNG Gene

mRNA/cDNA for RFNG Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFNG Gene

RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFNG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - - - - -
SP10: - - - - -
SP11: - - -
SP12: - - -

Relevant External Links for RFNG Gene

GeneLoc Exon Structure for
RFNG
ECgene alternative splicing isoforms for
RFNG

Expression for RFNG Gene

mRNA expression in normal human tissues for RFNG Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFNG Gene

SOURCE GeneReport for Unigene cluster for RFNG Gene Hs.569700

genes like me logo Genes that share expressions with RFNG: view

Orthologs for RFNG Gene

This gene was present in the common ancestor of animals.

Orthologs for RFNG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFNG 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RFNG 36
  • 87.76 (n)
  • 91.14 (a)
RFNG 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFNG 36
  • 83.04 (n)
  • 84.21 (a)
RFNG 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rfng 36
  • 83.15 (n)
  • 86.72 (a)
Rfng 16
Rfng 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 63 (a)
OneToMany
-- 37
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rfng 36
  • 82.23 (n)
  • 87.13 (a)
chicken
(Gallus gallus)
Aves RFNG 36
  • 72.2 (n)
  • 77.12 (a)
RFNG 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RFNG 37
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rfng 36
  • 67.04 (n)
  • 68.89 (a)
zebrafish
(Danio rerio)
Actinopterygii rfng 36
  • 70.71 (n)
  • 73.48 (a)
rfng 37
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006439 36
  • 52.21 (n)
  • 44.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta fng 36
  • 56.15 (n)
  • 49.81 (a)
fng 37
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
Species with no ortholog for RFNG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFNG Gene

ENSEMBL:
Gene Tree for RFNG (if available)
TreeFam:
Gene Tree for RFNG (if available)

Paralogs for RFNG Gene

Paralogs for RFNG Gene

Selected SIMAP similar genes for RFNG Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RFNG: view

Variants for RFNG Gene

Sequence variations from dbSNP and Humsavar for RFNG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12225 -- 82,048,009(+) GCGGG(C/G)AGGTG utr-variant-3-prime
rs1128009 -- 82,048,628(-) CGGCC(A/G)CACCA utr-variant-3-prime
rs1128018 -- 82,048,106(-) CAGGA(C/T)TACTT utr-variant-3-prime
rs4969482 -- 82,048,172(+) aatga(G/T)gcgcc utr-variant-3-prime
rs7215988 -- 82,047,860(+) GGACC(C/T)GAGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RFNG Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
dgv3349n71 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
dgv3350n71 CNV Loss 21882294
nsv909188 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
dgv3352n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294

Relevant External Links for RFNG Gene

HapMap Linkage Disequilibrium report
RFNG

Disorders for RFNG Gene

(1) University of Copenhagen DISEASES for RFNG Gene

genes like me logo Genes that share disorders with RFNG: view

No data available for UniProtKB/Swiss-Prot for RFNG Gene

Publications for RFNG Gene

  1. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PMID: 9187150) Johnston S.H. … Vogt T.F. (Development 1997) 2 3 4
  2. Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes. (PMID: 10341080) Moran J.L. … Vogt T.F. (Mamm. Genome 1999) 3 4
  3. Radical fringe negatively modulates Notch signaling in postmitotic neurons of the rat brain. (PMID: 11165380) Mikami T. … Itoh N. (Brain Res. Mol. Brain Res. 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RFNG Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RFNG
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RFNG
    • Block miRNA regulation of RFNG using miScript Target Protectors

    Sources for RFNG Gene

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