Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RFNG Gene

Aliases for RFNG Gene

  • RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 2 3 5
  • EC 4 63
  • O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 4
  • Radical Fringe (Drosophila) Homolog 2
  • Radical Fringe Homolog (Drosophila) 2

External Ids for RFNG Gene

Previous GeneCards Identifiers for RFNG Gene

  • GC17M079429
  • GC17M9J0047
  • GC17M080541
  • GC17M077599
  • GC17U900606
  • GC17M080005
  • GC17M075405

Summaries for RFNG Gene

GeneCards Summary for RFNG Gene

RFNG (RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with RFNG include Renal Cell Carcinoma, Papillary. Among its related pathways are Pre-NOTCH Expression and Processing and Notch Signaling Pathways. GO annotations related to this gene include transferase activity, transferring glycosyl groups and O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MFNG.

UniProtKB/Swiss-Prot for RFNG Gene

  • Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFNG Gene

Genomics for RFNG Gene

Regulatory Elements for RFNG Gene

Enhancers for RFNG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RFNG on UCSC Golden Path with GeneCards custom track

Promoters for RFNG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RFNG on UCSC Golden Path with GeneCards custom track

Genomic Location for RFNG Gene

82,047,902 bp from pter
82,051,831 bp from pter
3,930 bases
Minus strand

Genomic View for RFNG Gene

Genes around RFNG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFNG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFNG Gene

Proteins for RFNG Gene

  • Protein details for RFNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-1,3-N-acetylglucosaminyltransferase radical fringe
    Protein Accession:
    Secondary Accessions:
    • O00588

    Protein attributes for RFNG Gene

    331 amino acids
    Molecular mass:
    36424 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for RFNG Gene

Proteomics data for RFNG Gene at MOPED

Post-translational modifications for RFNG Gene

  • Glycosylation at Asn 113
  • Modification sites at PhosphoSitePlus

Other Protein References for RFNG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RFNG Gene

Gene Families for RFNG Gene

Protein Domains for RFNG Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 31 family.
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with RFNG: view

Function for RFNG Gene

Molecular function for RFNG Gene

GENATLAS Biochemistry:
radical fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH receptor genes for their specific ligands,essential mediator of somite segmentation and patterning
UniProtKB/Swiss-Prot CatalyticActivity:
Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.
UniProtKB/Swiss-Prot Function:
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity).

Enzyme Numbers (IUBMB) for RFNG Gene

genes like me logo Genes that share phenotypes with RFNG: view

Animal Models for RFNG Gene

MGI Knock Outs for RFNG:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RFNG Gene

Localization for RFNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFNG Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for RFNG Gene COMPARTMENTS Subcellular localization image for RFNG gene
Compartment Confidence
extracellular 5
golgi apparatus 4
cytoskeleton 2
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for RFNG Gene

Pathways & Interactions for RFNG Gene

genes like me logo Genes that share pathways with RFNG: view

Pathways by source for RFNG Gene

1 GeneGo (Thomson Reuters) pathway for RFNG Gene
1 R&D Systems pathway for RFNG Gene
1 Qiagen pathway for RFNG Gene

SIGNOR curated interactions for RFNG Gene


Gene Ontology (GO) - Biological Process for RFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0008152 metabolic process IEA --
GO:0009887 organ morphogenesis NAS 10341080
GO:0045747 positive regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with RFNG: view

Drugs & Compounds for RFNG Gene

No Compound Related Data Available

Transcripts for RFNG Gene

mRNA/cDNA for RFNG Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RFNG Gene

RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFNG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - - -
SP12: - - -

Relevant External Links for RFNG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFNG Gene

mRNA expression in normal human tissues for RFNG Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFNG Gene

SOURCE GeneReport for Unigene cluster for RFNG Gene Hs.569700

genes like me logo Genes that share expression patterns with RFNG: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RFNG Gene

Orthologs for RFNG Gene

This gene was present in the common ancestor of animals.

Orthologs for RFNG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RFNG 35
  • 87.76 (n)
  • 91.14 (a)
  • 88 (a)
(Canis familiaris)
Mammalia RFNG 35
  • 83.04 (n)
  • 84.21 (a)
  • 81 (a)
(Mus musculus)
Mammalia Rfng 35
  • 83.15 (n)
  • 86.72 (a)
Rfng 16
Rfng 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Rfng 35
  • 82.23 (n)
  • 87.13 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
-- 36
  • 66 (a)
(Pan troglodytes)
Mammalia RFNG 36
  • 96 (a)
(Gallus gallus)
Aves RFNG 35
  • 72.2 (n)
  • 77.12 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia RFNG 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rfng 35
  • 67.04 (n)
  • 68.89 (a)
(Danio rerio)
Actinopterygii rfng 35
  • 70.71 (n)
  • 73.48 (a)
rfng 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006439 35
  • 52.21 (n)
  • 44.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta fng 35
  • 56.15 (n)
  • 49.81 (a)
fng 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
-- 36
  • 46 (a)
-- 36
  • 42 (a)
-- 36
  • 41 (a)
-- 36
  • 41 (a)
-- 36
  • 45 (a)
-- 36
  • 38 (a)
-- 36
  • 36 (a)
-- 36
  • 35 (a)
-- 36
  • 33 (a)
-- 36
  • 34 (a)
-- 36
  • 43 (a)
-- 36
  • 42 (a)
-- 36
  • 43 (a)
-- 36
  • 42 (a)
-- 36
  • 42 (a)
-- 36
  • 45 (a)
Species with no ortholog for RFNG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFNG Gene

Gene Tree for RFNG (if available)
Gene Tree for RFNG (if available)

Paralogs for RFNG Gene

Paralogs for RFNG Gene

(2) SIMAP similar genes for RFNG Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RFNG: view

Variants for RFNG Gene

Sequence variations from dbSNP and Humsavar for RFNG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12225 -- 82,048,009(+) GCGGG(C/G)AGGTG utr-variant-3-prime
rs1128009 -- 82,048,628(-) CGGCC(A/G)CACCA utr-variant-3-prime
rs1128018 -- 82,048,106(-) CAGGA(C/T)TACTT utr-variant-3-prime
rs7215988 -- 82,047,860(+) GGACC(C/T)GAGGA downstream-variant-500B
rs8069068 -- 82,048,936(+) GTGGG(A/C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFNG Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
dgv3349n71 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
dgv3350n71 CNV Loss 21882294
nsv909188 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
dgv3352n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294

Variation tolerance for RFNG Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RFNG Gene

Disorders for RFNG Gene

MalaCards: The human disease database

(1) MalaCards diseases for RFNG Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search RFNG in MalaCards View complete list of genes associated with diseases

Relevant External Links for RFNG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RFNG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RFNG Gene

Publications for RFNG Gene

  1. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PMID: 9187150) Johnston S.H. … Vogt T.F. (Development 1997) 2 3 4 67
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Radical fringe negatively modulates Notch signaling in postmitotic neurons of the rat brain. (PMID: 11165380) Mikami T. … Itoh N. (Brain Res. Mol. Brain Res. 2001) 3

Products for RFNG Gene

Sources for RFNG Gene