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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFFL Gene

protein-coding   GIFtS: 56
GCID: GC17M033333

Ring Finger And FYVE-Like Domain Containing E3 Ubiquitin...

(Previous name: ring finger and FYVE-like domain containing)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger And FYVE-Like Domain Containing E3 Ubiquitin Protein
Ligase1 2
     CARP22
Caspase Regulator CARP22 3     FRING2
Caspases-8 And -10-Associated RING Finger Protein 22 3     RIFIFYLIN2
FYVE-RING Finger Protein Sakura2 3     E3 Ubiquitin-Protein Ligase Rififylin2
CARP-22 3     Ring Finger And FYVE-Like Domain Containing 12
RNF1892 3     EC 6.3.2.-3
RNF34L2 3     Fring3
RING Finger And FYVE-Like Domain-Containing Protein 12 3     RING Finger Protein 34-Like3
RING Finger Protein 1892 3     EC 6.3.28
Ring Finger And FYVE-Like Domain Containing1     

External Ids:    HGNC: 248211   Entrez Gene: 1175842   Ensembl: ENSG000000928717   OMIM: 6097355   UniProtKB: Q8WZ733   
ORGUL members:         
NONCODE14:n410546 n410544 n410545 n410547      

Export aliases for RFFL gene to outside databases

Previous GC identifers: GC17M030360 GC17M029522


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RFFL Gene: 
RFFL (ring finger and FYVE-like domain containing E3 ubiquitin protein ligase) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RFFL include narcolepsy, and prostatitis. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is RNF34.

UniProtKB/Swiss-Prot: RFFL_HUMAN, Q8WZ73
Function: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for
proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates

Gene Wiki entry for RFFL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFFL gene promoter:
         Max1   FOXF2   CUTL1   POU2F1   Ik-2   POU2F1a   c-Myb   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RFFL promoter sequence
   Search SABiosciences Chromatin IP Primers for RFFL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFFL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

RFFL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFFL gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M033333:  view genomic region     (about GC identifiers)

Start:
33,333,009 bp from pter      End:
33,416,348 bp from pter
Size:
83,340 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RFFL

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RFFL_HUMAN, Q8WZ73 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase rififylin  
Size: 363 amino acids; 40514 Da
Subunit: Binds CASP8 and CASP10
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein
1 PDB 3D structure from and Proteopedia for RFFL:
1Y02 (3D)    
Secondary accessions: E1P633 Q8NHW0 Q8TBY7 Q96BE6
Alternative splicing: 3 isoforms:  Q8WZ73-1   Q8WZ73-2   Q8WZ73-3   

Explore the universe of human proteins at neXtProt for RFFL: NX_Q8WZ73

Explore proteomics data for RFFL at MOPED 

Post-translational modifications:

  • UniProtKB: Rapidly degraded after stimulation with TNFSF10, probably by caspases
  • UniProtKB: Auto-ubiquitinated (in vitro) (By similarity)
  • UniProtKB: Palmitoylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WZ73

  • 3 DME Specific Peptides for RFFL (Q8WZ73)
     GCCEKWEL  VRQLKEILARNFVNY  IDCVLLECGHMVTCTKCGKRM 

    RFFL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RFFL Protein Expression
    REFSEQ proteins: NP_001017368.1  
    ENSEMBL proteins: 
     ENSP00000326170   ENSP00000463035   ENSP00000378096   ENSP00000389832   ENSP00000412322  
     ENSP00000408513   ENSP00000462656   ENSP00000462499   ENSP00000395090   ENSP00000464000  
     ENSP00000367777   ENSP00000268850  

    Human Recombinant Protein Products for RFFL: 
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    Cloud-Clone Corp. Proteins for RFFL 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    RFFL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q8WZ73

    ProtoNet protein and cluster: Q8WZ73

    3 Blocks protein domains:
    IPB000306 Zn-finger
    IPB001841 Zn-finger
    IPB003034 DNA-binding SAP


    UniProtKB/Swiss-Prot: RFFL_HUMAN, Q8WZ73
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 SAP domains


    RFFL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFFL_HUMAN, Q8WZ73
    Function: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for
    proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    RFFL for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RFFL:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty  Increased G1 DNA content 
     Increased cell size 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rffl):
     normal 

    RFFL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rffltm1Cota for RFFL

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RFFL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RFFL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFFL 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRFFL 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RFFL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF receptor signaling pathway
    TNF receptor signaling pathway


    1 BioSystems Pathway for RFFL
        TNF receptor signaling pathway


    UniProtKB/Swiss-Prot: RFFL_HUMAN, Q8WZ73
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFFL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for RFFL (Q8WZ733 ENSP000003261704) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2G2P606043, ENSP000003383484I2D: score=2 STRING: ENSP00000338348
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    RIPK1ENSP000002598084STRING: ENSP00000259808
    TNFRSF1AENSP000001627494STRING: ENSP00000162749
    TRADDENSP000003412684STRING: ENSP00000341268
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006915apoptotic process IEA--
    GO:0016567protein ubiquitination IEA--

    RFFL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RFFL

    Search CenterWatch for drugs/clinical trials and news about RFFL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RFFL gene (2 alternative transcripts): 
    NM_057178.3  NM_001017368.1  

    Unigene Cluster for RFFL:

    Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
    Hs.13680  [show with all ESTs]
    Unigene Representative Sequence: NR_037713
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315249(uc010cti.1 uc002hip.2 uc002hio.2) ENST00000580569
    ENST00000584655 ENST00000394597(uc002hin.1) ENST00000447669 ENST00000415395
    ENST00000413582 ENST00000581039 ENST00000584541 ENST00000582308 ENST00000414419
    ENST00000581265 ENST00000378516(uc002him.1) ENST00000268850(uc002hiq.2)

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate RFFL (see all 55):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-2052 hsa-miR-579 hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-30d hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidRFFL 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFFL

    Additional mRNA sequence: 

    AF434816.1 AK093112.1 AK308689.1 AY098935.1 BC015681.2 BC028424.1 CR933651.1 NR_037713.1 
    NR_037714.1 

    13 DOTS entries:

    DT.40296331  DT.70100523  DT.212992  DT.95164187  DT.91672980  DT.97789427  DT.97805008  DT.100026975 
    DT.100789501  DT.95221368  DT.120964097  DT.91992743  DT.95336943 

    24/183 AceView cDNA sequences (see all 183):

    BG059954 BC015681 CD368674 AI241579 NM_133629 AB018360 AB018361 AX747930 
    BI916871 BM476849 BC014422 AB013341 AI369733 AB018363 BX327473 BM915550 
    AB016223 BG060070 BE349405 NM_057178 BM739302 AK097811 AY098935 AA282406 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RFFL (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11 ^ 12
    SP1:                    -     -     -     -     -     -     -                       -                                                   
    SP2:                                                                                -                                                   
    SP3:                    -     -     -     -     -     -     -                                                                           
    SP4:                                                                                -                                                   
    SP5:                                      -     -     -     -                       -                                                   


    ECgene alternative splicing isoforms for RFFL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFFL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCTTGGT
    RFFL Expression
    About this image


    See RFFL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RFFL

    SOURCE GeneReport for Unigene cluster: Hs.13680

    UniProtKB/Swiss-Prot: RFFL_HUMAN, Q8WZ73
    Tissue specificity: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and
    peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFFL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RFFL gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rffl1 , 5 ring finger and FYVE like domain containing protein1, 5 88.89(n)1
    89.53(a)1
      11 (50.25 cM)5
    673381  NM_001007465.31  NP_001007466.11 
     828024495 
    chicken
    (Gallus gallus)
    Aves RFFL1 ring finger and FYVE-like domain containing 1 69.54(n)
    67.78(a)
      417529  NM_001030711.1  NP_001025882.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290632 Transcribed sequence with strong similarity to protein more 83.85(n)    CK141680.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170196
    --
    17(a)
    1 → many
    2R(8818417-8821550)


    ENSEMBL Gene Tree for RFFL (if available)
    TreeFam Gene Tree for RFFL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFFL gene
    RNF342  
    1 SIMAP similar gene for RFFL using alignment to 5 protein entries:     RFFL_HUMAN (see all proteins):
    RNF34

    RFFL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RFFL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2035CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609735    OMIM disorders: --

    2 diseases for RFFL:    About MalaCards
    narcolepsy    prostatitis


    RFFL for disorders           About GeneDecksing

    Genetic Association Database (GAD): RFFL
    Human Genome Epidemiology (HuGE) Navigator: RFFL (3 documents)

    Export disorders for RFFL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RFFL gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with RFFL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. (PubMed id 15229288)1, 3, 9 Coumailleau F....Cohen-Tannoudji M. (2004)
    2. Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2. (PubMed id 15576038)1, 2, 9 Tibbetts M.D....Shi Y. (2004)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    4. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    5. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C....Stricker B.H. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. (PubMed id 15069192)1, 2 McDonald E.R. III and El-Deiry W.S. (2004)
    9. The N-Terminal Extension of UBE2E Ubiquitin-Conjugatin g Enzymes Limits Chain Assembly. (PubMed id 23871895)1 Schumacher F.R....Day C.L. (2013)
    10. A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117584 HGNC: 24821 AceView: RAD51L3andRFFL Ensembl:ENSG00000092871 euGenes: HUgn117584
    ECgene: RFFL H-InvDB: RFFL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFFL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RFFL gene:
    Search GeneIP for patents involving RFFL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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