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Aliases for RFESD Gene

Aliases for RFESD Gene

  • Rieske Fe-S Domain Containing 2 3
  • Rieske (Fe-S) Domain Containing 2 5

External Ids for RFESD Gene

Previous GeneCards Identifiers for RFESD Gene

  • GC05P095009
  • GC05P094982
  • GC05P090172

Summaries for RFESD Gene

GeneCards Summary for RFESD Gene

RFESD (Rieske Fe-S Domain Containing) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and 2 iron, 2 sulfur cluster binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFESD Gene

Genomics for RFESD Gene

Regulatory Elements for RFESD Gene

Promoters for RFESD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RFESD on UCSC Golden Path with GeneCards custom track

Genomic Location for RFESD Gene

95,646,741 bp from pter
95,684,773 bp from pter
38,033 bases
Plus strand

Genomic View for RFESD Gene

Genes around RFESD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFESD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFESD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFESD Gene

Proteins for RFESD Gene

  • Protein details for RFESD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rieske domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • J3KPH1

    Protein attributes for RFESD Gene

    157 amino acids
    Molecular mass:
    17762 Da
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RFESD Gene


neXtProt entry for RFESD Gene

Proteomics data for RFESD Gene at MOPED

Post-translational modifications for RFESD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFESD Gene

Antibody Products

No data available for DME Specific Peptides for RFESD Gene

Domains & Families for RFESD Gene

Protein Domains for RFESD Gene


Suggested Antigen Peptide Sequences for RFESD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Rieske domains.
  • Contains 2 Rieske domains.
genes like me logo Genes that share domains with RFESD: view

No data available for Gene Families for RFESD Gene

Function for RFESD Gene

Gene Ontology (GO) - Molecular Function for RFESD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with RFESD: view
genes like me logo Genes that share phenotypes with RFESD: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFESD Gene

Localization for RFESD Gene

Subcellular locations from

Jensen Localization Image for RFESD Gene COMPARTMENTS Subcellular localization image for RFESD gene
Compartment Confidence
extracellular 2
golgi apparatus 2
mitochondrion 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFESD Gene

Pathways & Interactions for RFESD Gene

SuperPathways for RFESD Gene

No Data Available

Interacting Proteins for RFESD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8TAC1-RFESD_HUMAN ENSP00000369341 for RFESD Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for RFESD Gene


No data available for Pathways by source and SIGNOR curated interactions for RFESD Gene

Drugs & Compounds for RFESD Gene

No Compound Related Data Available

Transcripts for RFESD Gene

Unigene Clusters for RFESD Gene

Rieske (Fe-S) domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFESD Gene

No ASD Table

Relevant External Links for RFESD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFESD Gene

mRNA expression in normal human tissues for RFESD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFESD Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for RFESD Gene

This gene is overexpressed in Fetal Liver (16.6), Cerebral cortex (12.8), Spleen (12.8), Skin (11.1), and Ovary (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFESD Gene

SOURCE GeneReport for Unigene cluster for RFESD Gene Hs.399758

genes like me logo Genes that share expression patterns with RFESD: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RFESD Gene

Orthologs for RFESD Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFESD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RFESD 35
  • 91.03 (n)
  • 86.54 (a)
  • 85 (a)
(Canis familiaris)
Mammalia RFESD 35
  • 93.12 (n)
  • 90.32 (a)
  • 89 (a)
(Mus musculus)
Mammalia Rfesd 35
  • 87.26 (n)
  • 86.62 (a)
Rfesd 16
Rfesd 36
  • 87 (a)
(Pan troglodytes)
Mammalia RFESD 35
  • 99.52 (n)
  • 99.52 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rfesd 35
  • 85.06 (n)
  • 83.77 (a)
(Monodelphis domestica)
Mammalia RFESD 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia RFESD 36
  • 68 (a)
(Gallus gallus)
Aves RFESD 35
  • 64.86 (n)
  • 56.63 (a)
  • 49 (a)
(Anolis carolinensis)
Reptilia RFESD 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rfesd 35
  • 65.99 (n)
  • 57.82 (a)
(Danio rerio)
Actinopterygii LOC559859 35
  • 61.87 (n)
  • 56.82 (a)
rfesd 36
  • 35 (a)
RFESD (1 of 4) 36
  • 10 (a)
RFESD (2 of 4) 36
  • 50 (a)
RFESD (4 of 4) 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2103 36
  • 27 (a)
Species with no ortholog for RFESD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFESD Gene

Gene Tree for RFESD (if available)
Gene Tree for RFESD (if available)

Paralogs for RFESD Gene Pseudogenes for RFESD Gene

genes like me logo Genes that share paralogs with RFESD: view

No data available for Paralogs for RFESD Gene

Variants for RFESD Gene

Sequence variations from dbSNP and Humsavar for RFESD Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs213507 -- 95,651,062(-) GGAGT(A/G)CAGTG intron-variant
rs213885 -- 95,651,254(-) AAATA(C/T)AGTAA intron-variant
rs213887 -- 95,647,007(-) CGGTG(A/G)GTCTC intron-variant, utr-variant-5-prime
rs213888 -- 95,646,289(-) TTAGC(C/T)GGGCG upstream-variant-2KB
rs5869684 -- 95,649,136(+) TAATT(-/A)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFESD Gene

Variant ID Type Subtype PubMed ID
esv2659181 CNV Deletion 23128226

Variation tolerance for RFESD Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 61.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFESD Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFESD Gene

Disorders for RFESD Gene

Relevant External Links for RFESD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RFESD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFESD Gene

Publications for RFESD Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Decoding the fine-scale structure of a breast cancer genome and transcriptome. (PMID: 16461635) Volik S. … Collins C. (Genome Res. 2006) 3

Products for RFESD Gene

Sources for RFESD Gene

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