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RFC5 Gene

protein-coding   GIFtS: 65
GCID: GC12P118454

Replication Factor C (Activator 1) 5, 36.5kDa

(Previous name: replication factor C (activator 1) 5 (36.5kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Replication Factor C (Activator 1) 5, 36.5kDa1 2     Replication Factor C, 36-KDa Subunit2
RFC362 3     RFC, 36.5 KD Subunit2
A1 36 KDa Subunit2 3     Activator 1 36 KDa Subunit3
RF-C 36 KDa Subunit2 3     Activator 1 Subunit 53
Replication Factor C (Activator 1) 5 (36.5kD)1     Replication Factor C 36 KDa Subunit3
Replication Factor C Subunit 52     

External Ids:    HGNC: 99731   Entrez Gene: 59852   Ensembl: ENSG000001114457   OMIM: 6004075   UniProtKB: P409373   

Export aliases for RFC5 gene to outside databases

Previous GC identifers: GC12U990087 GC12P117975 GC12P118237 GC12P116866 GC12P116917 GC12P115465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RFC5 Gene:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory
proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1,
is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36
kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and
40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by
PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene
has been identified on chromosome 9. (provided by RefSeq, May 2011)

GeneCards Summary for RFC5 Gene:
RFC5 (replication factor C (activator 1) 5, 36.5kDa) is a protein-coding gene. Diseases associated with RFC5 include ocular melanoma, and barrett's esophagus. GO annotations related to this gene include nucleoside-triphosphatase activity and enzyme binding.

UniProtKB/Swiss-Prot: RFC5_HUMAN, P40937
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

Gene Wiki entry for RFC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RFC5 gene promoter:
         E2F-4   E2F-3a   E2F-2   NF-E2 p45   CREB   E2F   E2F-1   HSF2   ARP-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFC5 promoter sequence
   Search Chromatin IP Primers for RFC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.3

RFC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFC5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P118454:  view genomic region     (about GC identifiers)

Start:
118,451,393 bp from pter      End:
118,470,935 bp from pter
Size:
19,543 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RFC5_HUMAN, P40937 (See protein sequence)
Recommended Name: Replication factor C subunit 5  
Size: 340 amino acids; 38497 Da
Subunit: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with
RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not
stimulated by PCNA
1 PDB 3D structure from and Proteopedia for RFC5:
1LFS (3D)    
Secondary accessions: A8MZ62 B3KSX8
Alternative splicing: 2 isoforms:  P40937-1   P40937-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RFC5: NX_P40937

Explore proteomics data for RFC5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16, Lys25, Lys66
  • Modification sites at PhosphoSitePlus

  • See RFC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001123584.1  NP_001193730.1  NP_031396.1  NP_853556.2  

    ENSEMBL proteins: 
     ENSP00000393636   ENSP00000443187   ENSP00000445917   ENSP00000390340   ENSP00000408295  
     ENSP00000376325   ENSP00000438252   ENSP00000229043  
    Reactome Protein details: P40937

    RFC5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RFC5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RFC5
    GenScript Custom Purified and Recombinant Proteins Services for RFC5
    Novus Biologicals RFC5 Protein
    Novus Biologicals RFC5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFC5

    RFC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RFC5
    Novus Biologicals RFC5 Antibodies
    Abcam antibodies for RFC5
    Cloud-Clone Corp. Antibodies for RFC5
    ThermoFisher Antibodies for RFC5
    LSBio Antibodies in human, mouse, rat for RFC5

    RFC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RFC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RFC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RFC5
    Cloud-Clone Corp. CLIAs for RFC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    5 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR008921 DNA_pol3_clamp-load_cplx_C
     IPR013748 Rep_factorC_C_dom
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P40937

    ProtoNet protein and cluster: P40937

    1 Blocks protein domain: IPB013748 Replication factor C

    UniProtKB/Swiss-Prot: RFC5_HUMAN, P40937
    Similarity: Belongs to the activator 1 small subunits family


    RFC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFC5_HUMAN, P40937
    Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
    accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

         Genatlas biochemistry entry for RFC5:
    replication factor C5,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP
    dependent,required to assemble PCNA and polymerase delta on the DNA template

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0009378four-way junction helicase activity ----
         
    RFC5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RFC5:
     Synthetic lethal with Ras  Synthetic lethal with paclitax 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RFC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RFC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target RFC5:
    hsa-mir-1 (MIRT023584), hsa-mir-339-5p (MIRT042743), hsa-mir-193b-3p (MIRT016278)

    Block miRNA regulation of human, mouse, rat RFC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RFC5 (see all 11):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p hsa-miR-548y hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidRFC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RFC5
    Predesigned siRNA for gene silencing in human, mouse, rat RFC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RFC5

    Clone
    Products:
         
    OriGene clones in human, mouse for RFC5 (see all 28)
    OriGene ORF clones in mouse, rat for RFC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RFC5 (NM_007370)
    Sino Biological Human cDNA Clone for RFC5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RFC5
    Browse ESI BIO Cell Lines and PureStem Progenitors for RFC5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFC5_HUMAN, P40937: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    peroxisome2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005663DNA replication factor C complex IDA9488738

    RFC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RFC5 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Telomere C-strand (Lagging Strand) Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Cell cycle Transition and termination of DNA replication0.43
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Polymerase switching on the C-strand of the telomere0.00
    Telomere C-strand (Lagging Strand) Synthesis0.79
    Lagging Strand Synthesis0.00
    Extension of Telomeres0.79
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.00
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Nucleotide Excision Repair Pathway0.48
    Nucleotide excision repair0.69
    3DNA strand elongation
    DNA strand elongation0.63
    DNA replication0.63
    4CDK-mediated phosphorylation and removal of Cdc6
    Synthesis of DNA0.92
    S Phase0.78
    DNA Replication0.92
    Cell Cycle Checkpoints0.58
    5DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    DNA Repair0.45
    Nucleotide Excision Repair0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RFC5
        Mismatch Repair in Eukaryotes
    Nucleotide Excision Repair Pathway

    1 GeneGo (Thomson Reuters) Pathway for RFC5
        Cell cycle Transition and termination of DNA replication

    2 BioSystems Pathways for RFC5
        DNA Replication
    RB in Cancer


    5 Reactome Pathways for RFC5
        Polymerase switching on the C-strand of the telomere
    Repair synthesis for gap-filling by DNA polymerase in TC-NER
    Activation of ATR in response to replication stress
    Polymerase switching
    Repair synthesis of patch ~27-30 bases long by DNA polymerase


    3 Kegg Pathways  (Kegg details for RFC5):
        DNA replication
    Nucleotide excision repair
    Mismatch repair


    RFC5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFC5
    Interactions:

        GeneGlobe Interaction Network for RFC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RFC5 (P409371, 2, 3 ENSP000004082954) via UniProtKB, MINT, STRING, and/or I2D (see all 959)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000221413
    COPS6Q7L5N12, 3MINT-7945693 MINT-63723 I2D: score=5 
    EEF1A1P681042, 3MINT-7945693 MINT-7947479 I2D: score=4 
    PSMC4P436862, 3MINT-7945693 MINT-7947479 I2D: score=4 
    DNAJA1P316892, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0006260DNA replication TAS--
    GO:0006271DNA strand elongation involved in DNA replication TAS--

    RFC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFC5

    1 DrugBank Compound for RFC5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RFC5 gene (5 alternative transcripts): 
    NM_001130112.2  NM_001206801.1  NM_007370.5  NM_181578.3  NM_001130113.1  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449641 ENST00000537315 ENST00000484086 ENST00000420967 ENST00000454402
    ENST00000392542(uc010syx.2) ENST00000535092 ENST00000472603 ENST00000543153
    ENST00000229043(uc010syz.2 uc001twq.3 uc009zwr.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RFC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RFC5 (see all 11):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p hsa-miR-548y hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidRFC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RFC5
    Predesigned siRNA for gene silencing in human, mouse, rat RFC5
    Clone
    Products:
         
    OriGene clones in human, mouse for RFC5 (see all 28)
    OriGene ORF clones in mouse, rat for RFC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RFC5 (NM_007370)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RFC5
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFC5
      QuantiTect SYBR Green Assays in human, mouse, rat RFC5
      QuantiFast Probe-based Assays in human, mouse, rat RFC5

    Selected AceView cDNA sequences (see all 296):

    BC013961 BQ013335 AI276049 AW959369 BF438209 AA984017 AI371465 BE670340 
    AI498032 CA390335 BF438112 BE252925 AI383180 BU162275 BE797316 AW651734 
    CB266982 AA281878 AW134575 CR407651 BU169958 AU121576 Z39981 AI218403 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RFC5 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                                                                                              -                                 
    SP2:                          -     -     -                                                                       -                                 
    SP3:                          -     -     -                                                                       -     -                           
    SP4:                                -     -                                                                                                         
    SP5:                          -     -                                                                                                               


    ECgene alternative splicing isoforms for RFC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RFC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCATTTGT
    RFC5 Expression
    About this image

    RFC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFC5 Protein Expression
        Custom PCR Arrays for RFC5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RFC5
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFC5
    QuantiTect SYBR Green Assays in human, mouse, rat RFC5
    QuantiFast Probe-based Assays in human, mouse, rat RFC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RFC5 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfc51 , 5 replication factor C (activator 1) 51, 5 86.59(n)1
    94.38(a)1
      5 (56.88 cM)5
    721511  NM_028128.11  NP_082404.11 
     1173781035 
    chicken
    (Gallus gallus)
    Aves RFC51 replication factor C (activator 1) 5, 36.5kDa 76.33(n)
    89.67(a)
      100859719  XM_004934476.1  XP_004934533.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFC56
    replication factor C (activator 1) 5, 36.5kDa
    87(a)
    1 ↔ 1
    LGb(2703148-2718966)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044712.12   -- 76.84(n)    BC044712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD759553.12   -- 79.22(n)    CD759553.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RfC31 , 3 DNA replication DNA binding3
    Replication factor C subunit 31
    61(a)3
    58.23(n)1
    62.19(a)1
      31E13
    344231  NM_135555.31  NP_609399.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F44B9.81 , 3 ARPA3
    F44B9.81
    47(a)3
    56.79(n)1
    52.16(a)1
      III(8100061-8101395)3
    1761311  NM_066349.41  NP_498750.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RFC3(YNL290W)4
    RFC31
    Subunit of heteropentameric Replication factor C (RF-C), more4
    RFC31
    55.25(n)1
    51.85(a)1
      14(86218-87240)4
    8554261, 4  NP_014109.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RFC31 RFC3 60.5(n)
    59.87(a)
      844083  NM_106396.4  NP_177871.1 
    rice
    (Oryza sativa)
    Liliopsida Os.22122 Oryza sativa (japonica cultivar-group) OsRFC3 mRNA more 72.64(n)    AB038319.1 


    ENSEMBL Gene Tree for RFC5 (if available)
    TreeFam Gene Tree for RFC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RFC5 gene
    2 SIMAP similar genes for RFC5 using alignment to 8 protein entries:     RFC5_HUMAN (see all proteins):
    RFC4    RFC2

    RFC5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RFC5
    PGOHUM00000236650


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RFC5 (see all 426)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124735541,2
    F--118452551(+) CAACAG/ATTAGA 4 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs100829521,2
    C--118452647(+) AATTGG/TATCAG 4 -- us2k10--------
    rs1900639551,2
    --118452853(+) TGAGAC/TCTTCT 4 -- us2k10--------
    rs1810916661,2
    --118453197(+) CTGTCA/TCATCA 4 -- us2k10--------
    rs1394218301,2
    --118453205(+) TCACAA/CGCCCT 4 -- us2k10--------
    rs1847963511,2
    --118453227(+) TTCTTC/TGGGGT 4 -- us2k10--------
    rs759411421,2
    C,F--118453243(+) GGCAGG/AGGCTA 4 -- us2k12Minor allele frequency- A:0.06CSA EA 122
    rs1894112011,2
    --118453459(+) TGGATG/TCTTTG 4 -- us2k10--------
    rs1496495841,2
    --118453510(+) TGGCTA/CACGCC 4 -- us2k10--------
    rs1809533191,2
    --118453512(+) GCTCAC/GGCCTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RFC5 (118451393 - 118470935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RFC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271713CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RFC5
    DNA2.0 Custom Variant and Variant Library Synthesis for RFC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600407    OMIM disorders: --

    9 diseases for RFC5:    
    About MalaCards
    ocular melanoma    barrett's esophagus    graft versus host disease    multiple sclerosis
    melanoma    squamous cell carcinoma    obesity    hepatitis
    malaria


    RFC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RFC5
    Human Genome Epidemiology (HuGE) Navigator: RFC5 (7 documents)

    Export disorders for RFC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFC5 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with RFC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    2. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PubMed id 20226869)1, 4 Thyagarajan B....Arora M. (Biol. Blood Marrow Transplant. 2010)
    3. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PubMed id 20574454)1, 4 Arora M....Thyagarajan B. (Leukemia 2010)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Purification and characterization of human DNA damage checkpoint Rad complexes. (PubMed id 11572977)1, 2 Lindsey-Boltz L.A.... Sancar A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. (PubMed id 8999859)1, 2 Mossi R.... Huebscher U. (J. Biol. Chem. 1997)
    10. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PubMed id 7774928)1, 3 Okumura K....Ozawa K. (Genomics 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5985 HGNC: 9973 AceView: RFC5 Ensembl:ENSG00000111445 euGenes: HUgn5985
    ECgene: RFC5 Kegg: 5985 H-InvDB: RFC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RFC5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RFC5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rfc5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RFC5 gene:
    Search GeneIP for patents involving RFC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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