Aliases for RFC5 Gene
External Ids for RFC5 Gene
Previous GeneCards Identifiers for RFC5 Gene
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]
GeneCards Summary for RFC5 Gene
RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RB in Cancer. GO annotations related to this gene include enzyme binding and DNA clamp loader activity.
UniProtKB/Swiss-Prot for RFC5 Gene
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.