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Aliases for RFC5 Gene

Aliases for RFC5 Gene

  • Replication Factor C Subunit 5 2 3 5
  • Replication Factor C (Activator 1) 5, 36.5kDa 2 3
  • RF-C 36 KDa Subunit 3 4
  • A1 36 KDa Subunit 3 4
  • RFC36 3 4
  • Replication Factor C (Activator 1) 5 (36.5kD) 2
  • Replication Factor C, 36-KDa Subunit 3
  • Replication Factor C 36 KDa Subunit 4
  • Activator 1 36 KDa Subunit 4
  • Activator 1 Subunit 5 4
  • RFC, 36.5 KD Subunit 3

External Ids for RFC5 Gene

Previous GeneCards Identifiers for RFC5 Gene

  • GC12U990087
  • GC12P118237
  • GC12P116866
  • GC12P116917
  • GC12P118454
  • GC12P115465

Summaries for RFC5 Gene

Entrez Gene Summary for RFC5 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]

GeneCards Summary for RFC5 Gene

RFC5 (Replication Factor C Subunit 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. GO annotations related to this gene include enzyme binding and DNA clamp loader activity.

UniProtKB/Swiss-Prot for RFC5 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Gene Wiki entry for RFC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFC5 Gene

Genomics for RFC5 Gene

Regulatory Elements for RFC5 Gene

Genomic Location for RFC5 Gene

Chromosome:
12
Start:
118,013,588 bp from pter
End:
118,033,564 bp from pter
Size:
19,977 bases
Orientation:
Plus strand

Genomic View for RFC5 Gene

Genes around RFC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFC5 Gene

Proteins for RFC5 Gene

  • Protein details for RFC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40937-RFC5_HUMAN
    Recommended name:
    Replication factor C subunit 5
    Protein Accession:
    P40937
    Secondary Accessions:
    • A8MZ62
    • B3KSX8

    Protein attributes for RFC5 Gene

    Size:
    340 amino acids
    Molecular mass:
    38497 Da
    Quaternary structure:
    • Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.

    Three dimensional structures from OCA and Proteopedia for RFC5 Gene

    Alternative splice isoforms for RFC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFC5 Gene

Proteomics data for RFC5 Gene at MOPED

Post-translational modifications for RFC5 Gene

  • Ubiquitination at Lys 7, Lys 16, Lys 25, and Lys 66
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RFC5 Gene

Domains & Families for RFC5 Gene

Gene Families for RFC5 Gene

Graphical View of Domain Structure for InterPro Entry

P40937

UniProtKB/Swiss-Prot:

RFC5_HUMAN :
  • Belongs to the activator 1 small subunits family.
Family:
  • Belongs to the activator 1 small subunits family.
genes like me logo Genes that share domains with RFC5: view

Function for RFC5 Gene

Molecular function for RFC5 Gene

GENATLAS Biochemistry:
replication factor C5,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP dependent,required to assemble PCNA and polymerase delta on the DNA template
UniProtKB/Swiss-Prot Function:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Gene Ontology (GO) - Molecular Function for RFC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with RFC5: view
genes like me logo Genes that share phenotypes with RFC5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RFC5 Gene

Localization for RFC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFC5 Gene COMPARTMENTS Subcellular localization image for RFC5 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RFC5 Gene

Pathways & Interactions for RFC5 Gene

SuperPathways for RFC5 Gene

Superpath Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 DNA Double-Strand Break Repair
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Homologous DNA Pairing and Strand Exchange
genes like me logo Genes that share pathways with RFC5: view

Pathways by source for RFC5 Gene

Gene Ontology (GO) - Biological Process for RFC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance TAS --
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006260 DNA replication IEA,TAS --
GO:0006261 DNA-dependent DNA replication IBA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with RFC5: view

No data available for SIGNOR curated interactions for RFC5 Gene

Drugs & Compounds for RFC5 Gene

No Compound Related Data Available

Transcripts for RFC5 Gene

Unigene Clusters for RFC5 Gene

Replication factor C (activator 1) 5, 36.5kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8:
SP9:

Relevant External Links for RFC5 Gene

GeneLoc Exon Structure for
RFC5
ECgene alternative splicing isoforms for
RFC5

Expression for RFC5 Gene

mRNA expression in normal human tissues for RFC5 Gene

Protein differential expression in normal tissues from HIPED for RFC5 Gene

This gene is overexpressed in Bone (21.4), Peripheral blood mononuclear cells (10.0), and Breast (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFC5 Gene



SOURCE GeneReport for Unigene cluster for RFC5 Gene Hs.731908

genes like me logo Genes that share expression patterns with RFC5: view

Protein tissue co-expression partners for RFC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RFC5 Gene

Orthologs for RFC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RFC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFC5 36
  • 99 (a)
OneToOne
RFC5 35
  • 99.31 (n)
  • 99.12 (a)
cow
(Bos Taurus)
Mammalia RFC5 35
  • 89.15 (n)
  • 95.93 (a)
RFC5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFC5 36
  • 89 (a)
OneToOne
RFC5 35
  • 89.64 (n)
  • 97.85 (a)
mouse
(Mus musculus)
Mammalia Rfc5 16
Rfc5 36
  • 94 (a)
OneToOne
Rfc5 35
  • 86.59 (n)
  • 94.38 (a)
oppossum
(Monodelphis domestica)
Mammalia RFC5 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFC5 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rfc5 35
  • 85.76 (n)
  • 93.77 (a)
chicken
(Gallus gallus)
Aves RFC5 35
  • 76.33 (n)
  • 89.67 (a)
RFC5 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RFC5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rfc5 35
  • 75.6 (n)
  • 87.35 (a)
Str.101 35
zebrafish
(Danio rerio)
Actinopterygii rfc5 36
  • 82 (a)
OneToOne
rfc5 35
  • 71.97 (n)
  • 82.88 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005144 35
  • 63.11 (n)
  • 68.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta RfC3 35
  • 58.23 (n)
  • 62.19 (a)
RfC3 37
  • 61 (a)
RfC3 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F44B9.8 35
  • 56.79 (n)
  • 52.16 (a)
F44B9.8 36
  • 46 (a)
OneToOne
F44B9.8 37
  • 47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL196W 35
  • 53.48 (n)
  • 52.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFC3 35
  • 55.25 (n)
  • 51.85 (a)
RFC3 36
  • 49 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13201g 35
  • 53.35 (n)
  • 50.31 (a)
soybean
(Glycine max)
eudicotyledons Gma.7568 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RFC3 35
  • 60.5 (n)
  • 59.87 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11639 35
rice
(Oryza sativa)
Liliopsida Os.2212 35
Os02g0775200 35
  • 59.52 (n)
  • 58.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08427 35
  • 52.67 (n)
  • 52.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rfc3 35
  • 54.71 (n)
  • 53.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8316 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6453 36
  • 64 (a)
OneToOne
Species with no ortholog for RFC5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RFC5 Gene

ENSEMBL:
Gene Tree for RFC5 (if available)
TreeFam:
Gene Tree for RFC5 (if available)

Paralogs for RFC5 Gene

(2) SIMAP similar genes for RFC5 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for RFC5 Gene

genes like me logo Genes that share paralogs with RFC5: view

No data available for Paralogs for RFC5 Gene

Variants for RFC5 Gene

Sequence variations from dbSNP and Humsavar for RFC5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1137859 -- 118,031,325(+) ATGGG(A/T)GAACA utr-variant-3-prime
rs1137860 -- 118,031,327(+) GGGAG(A/T)ACAGA utr-variant-3-prime
rs1137861 -- 118,031,328(+) GGAGA(A/T)CAGAG utr-variant-3-prime
rs5745791 -- 118,016,408(+) TTGAG(C/G)CCCGG upstream-variant-2KB
rs5745792 -- 118,016,496(+) TGTAA(C/T)GATGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RFC5 Gene

Variant ID Type Subtype PubMed ID
esv271713 CNV Insertion 20981092

Variation tolerance for RFC5 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFC5 Gene

HapMap Linkage Disequilibrium report
RFC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFC5 Gene

Disorders for RFC5 Gene

Relevant External Links for RFC5

Genetic Association Database (GAD)
RFC5
Human Genome Epidemiology (HuGE) Navigator
RFC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFC5

No disorders were found for RFC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFC5 Gene

Publications for RFC5 Gene

  1. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PMID: 20522537) Briggs F.B. … Barcellos L.F. (Am. J. Epidemiol. 2010) 3 48 67
  2. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PMID: 7774928) Okumura K. … Ozawa K. (Genomics 1995) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RFC5 Gene

Sources for RFC5 Gene

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