Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RFC4 Gene

protein-coding   GIFtS: 65
GCID: GC03M186507

Replication Factor C (Activator 1) 4, 37kDa

(Previous name: replication factor C (activator 1) 4 (37kD))
  Search for RFC4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Replication Factor C (Activator 1) 4, 37kDa1 2     RFC372 3
A1 37 KDa Subunit1 2 3     RF-C 37 KDa Subunit2 3
Activator 1 37 KDa Subunit1 2 3     Replication Factor C (Activator 1) 4 (37kD)1
RFC 37 KDa Subunit1 2     A12
Activator 1 Subunit 42 3     Replication Factor C Subunit 42
Replication Factor C 37 KDa Subunit2 3     

External Ids:    HGNC: 99721   Entrez Gene: 59842   Ensembl: ENSG000001639187   OMIM: 1025775   UniProtKB: P352493   

Export aliases for RFC4 gene to outside databases

Previous GC identifers: GC03M183282 GC03M187764 GC03M187909 GC03M187828 GC03M187990 GC03M183917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RFC4 Gene:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory
proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1,
is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37
kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses
DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively
spliced transcript variants encoding the same protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RFC4 Gene:
RFC4 (replication factor C (activator 1) 4, 37kDa) is a protein-coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot: RFC4_HUMAN, P35249
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the
elongation of the multiprimed DNA template

Gene Wiki entry for RFC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the RFC4 gene promoter:
         MEF-2A   Max   Sp1   aMEF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFC4 promoter sequence
   Search Chromatin IP Primers for RFC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27

RFC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFC4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M186507:  view genomic region     (about GC identifiers)

Start:
186,507,669 bp from pter      End:
186,524,847 bp from pter
Size:
17,179 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RFC4_HUMAN, P35249 (See protein sequence)
Recommended Name: Replication factor C subunit 4  
Size: 363 amino acids; 39682 Da
Subunit: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with
RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not
stimulated by PCNA
Miscellaneous: Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP
Secondary accessions: D3DNV2 Q6FHX7

Explore the universe of human proteins at neXtProt for RFC4: NX_P35249

Explore proteomics data for RFC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64, Lys240
  • Modification sites at PhosphoSitePlus

  • See RFC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002907.1  NP_853551.1  

    ENSEMBL proteins: 
     ENSP00000399769   ENSP00000296273   ENSP00000401429   ENSP00000411300   ENSP00000394870  
     ENSP00000413065   ENSP00000407982   ENSP00000415099   ENSP00000399314   ENSP00000376272  
    Reactome Protein details: P35249

    RFC4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RFC4
    OriGene Protein Over-expression Lysate for RFC4
    OriGene MassSpec for RFC4
    OriGene Custom Protein Services for RFC4
    GenScript Custom Purified and Recombinant Proteins Services for RFC4
    Novus Biologicals RFC4 Proteins
    Novus Biologicals RFC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFC4

     
    Search eBioscience for Proteins for RFC4 

    RFC4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RFC4
    OriGene Custom Antibody Services for RFC4
    Novus Biologicals RFC4 Antibodies
    Abcam antibodies for RFC4
    Cloud-Clone Corp. Antibodies for RFC4
    ThermoFisher Antibody for RFC4
    LSBio Antibodies in human, mouse, rat for RFC4

    RFC4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RFC4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RFC4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RFC4
    Cloud-Clone Corp. CLIAs for RFC4
    Search eBioscience for ELISAs for RFC4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    AATP: ATPases / AAA-type

    5 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR008921 DNA_pol3_clamp-load_cplx_C
     IPR013748 Rep_factorC_C_dom
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P35249

    ProtoNet protein and cluster: P35249

    1 Blocks protein domain: IPB013748 Replication factor C

    UniProtKB/Swiss-Prot: RFC4_HUMAN, P35249
    Similarity: Belongs to the activator 1 small subunits family


    Find genes that share domains with RFC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFC4_HUMAN, P35249
    Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
    accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the
    elongation of the multiprimed DNA template

         Genatlas biochemistry entry for RFC4:
    replication factor C4,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP
    dependent,required to assemble PCNA and polymerase delta on the DNA template

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI15655353
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    Find genes that share ontologies with RFC4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RFC4:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RFC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RFC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target RFC4:
    hsa-mir-215-5p (MIRT024441), hsa-mir-193b-3p (MIRT016352), hsa-mir-192-5p (MIRT026479)

    Block miRNA regulation of human, mouse, rat RFC4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RFC4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RFC4
    Predesigned siRNA for gene silencing in human, mouse, rat RFC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RFC4

    Clone
    Products:
         
    OriGene clones in human, mouse for RFC4 (see all 12)
    OriGene ORF clones in mouse, rat for RFC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFC4 (NM_002916)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RFC4
    Browse ESI BIO Cell Lines and PureStem Progenitors for RFC4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RFC4_HUMAN, P35249: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005663DNA replication factor C complex IDA9488738

    Find genes that share ontologies with RFC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RFC4 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Telomere C-strand (Lagging Strand) Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Cell cycle Transition and termination of DNA replication0.43
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Polymerase switching on the C-strand of the telomere0.00
    Telomere C-strand (Lagging Strand) Synthesis0.79
    Lagging Strand Synthesis0.00
    Extension of Telomeres0.79
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.00
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Nucleotide Excision Repair Pathway0.48
    Nucleotide excision repair0.69
    3DNA strand elongation
    DNA strand elongation0.63
    DNA replication0.63
    4CDK-mediated phosphorylation and removal of Cdc6
    Synthesis of DNA0.92
    S Phase0.78
    DNA Replication0.92
    Cell Cycle Checkpoints0.58
    5DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    DNA Repair0.45
    Nucleotide Excision Repair0.90


    Find genes that share SuperPaths with RFC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RFC4
        Mismatch Repair in Eukaryotes
    Nucleotide Excision Repair Pathway

    1 GeneGo (Thomson Reuters) Pathway for RFC4
        Cell cycle Transition and termination of DNA replication

    3 BioSystems Pathways for RFC4
        Gastric cancer network 2
    DNA Replication
    RB in Cancer

    5 Reactome Pathways for RFC4
        Polymerase switching on the C-strand of the telomere
    Repair synthesis for gap-filling by DNA polymerase in TC-NER
    Activation of ATR in response to replication stress
    Polymerase switching
    Repair synthesis of patch ~27-30 bases long by DNA polymerase


    3 Kegg Pathways  (Kegg details for RFC4):
        DNA replication
    Nucleotide excision repair
    Mismatch repair

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFC4
    Interactions:

        GeneGlobe Interaction Network for RFC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RFC4 (P352491, 2, 3 ENSP000002962734) via UniProtKB, MINT, STRING, and/or I2D (see all 948)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000317334
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000362649
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000221413
    SNRNP200O756432, 3MINT-7945693 MINT-7947479 I2D: score=4 
    POLD1P283402, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0006260DNA replication TAS--
    GO:0006271DNA strand elongation involved in DNA replication TAS--

    Find genes that share ontologies with RFC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFC4

    1 Novoseek inferred chemical compound relationship for RFC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 37.1 2 1670772 (2)



    Find genes that share compounds with RFC4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RFC4 gene (2 alternative transcripts): 
    NM_002916.3  NM_181573.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433496 ENST00000479307 ENST00000296273(uc003fqz.3) ENST00000417876
    ENST00000494047(uc011bsd.2) ENST00000460408 ENST00000418288 ENST00000449502
    ENST00000447345 ENST00000489028 ENST00000427785 ENST00000448497 ENST00000411792
    ENST00000392481(uc011bsc.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RFC4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RFC4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RFC4
    Predesigned siRNA for gene silencing in human, mouse, rat RFC4
    Clone
    Products:
         
    OriGene clones in human, mouse for RFC4 (see all 12)
    OriGene ORF clones in mouse, rat for RFC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFC4 (NM_002916)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RFC4
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFC4
      QuantiTect SYBR Green Assays in human, mouse, rat RFC4
      QuantiFast Probe-based Assays in human, mouse, rat RFC4

    Selected AceView cDNA sequences (see all 300):

    BG498617 BU169798 CR616552 CA310578 AW327326 CR604460 AA747481 AL601693 
    AA704058 CR625223 AL526272 BU170012 AA354089 BC024022 AK094454 BU158657 
    BM472875 CB164230 CR608475 BX366379 AL525156 AL522957 F08084 AI189808 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RFC4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                          -                 -                                         -                     
    SP2:              -           -                 -                                                               
    SP3:                                                                                                            
    SP4:                                            -                                                               


    ECgene alternative splicing isoforms for RFC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RFC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGGTTGT
    RFC4 Expression
    About this image


    RFC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Larynx (Respiratory System)
    RFC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFC4 Protein Expression
        Custom PCR Arrays for RFC4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RFC4
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFC4
    QuantiTect SYBR Green Assays in human, mouse, rat RFC4
    QuantiFast Probe-based Assays in human, mouse, rat RFC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RFC4 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfc41 , 5 replication factor C (activator 1) 41, 5 87.05(n)1
    91.18(a)1
      16 (13.93 cM)5
    1063441  NM_145480.11  NP_663455.11 
     231139435 
    chicken
    (Gallus gallus)
    Aves RFC41 replication factor C (activator 1) 4, 37kDa 76(n)
    84.31(a)
      424958  NM_001006550.2  NP_001006550.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFC46
    replication factor C (activator 1) 4, 37kDa
    82(a)
    1 ↔ 1
    GL343321.1(80312-110295)
    African clawed frog
    (Xenopus laevis)
    Amphibia RFC22 replication factor C p37 subunit 76.64(n)    AB080268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb82e022 Danio rerio cDNA clone MGC64030 IMAGE6793333, complete more 75.06(n)    BC054598.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81421 , 3 DNA replication DNA binding3
    CG81421
    54(a)3
    52.76(n)1
    55.14(a)1
      16E13
    327631  NM_133017.31  NP_573245.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rfc-43 Replication factor C 43(a)   III(7043840-7045403)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RFC2(YJR068W)4
    RFC21
    Subunit of heteropentameric Replication factor C (RF-C), more4
    RFC21
    54.96(n)1
    54.55(a)1
      10(567643-568704)4
    8535311, 4  NP_012602.31  NP_012602.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB19681 EMB1968 57.66(n)
    57.14(a)
      838771  NM_102018.3  NP_564148.1 
    rice
    (Oryza sativa)
    Liliopsida Os.2762 Oryza sativa (japonica cultivar-group) OsRFC2 mRNA more 70.85(n)    AB045677.1 


    ENSEMBL Gene Tree for RFC4 (if available)
    TreeFam Gene Tree for RFC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RFC4 gene
    2 SIMAP similar genes for RFC4 using alignment to 10 protein entries:     RFC4_HUMAN (see all proteins):
    RFC5    RFC2

    Find genes that share paralogs with RFC4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RFC4 (see all 443)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361214
    A breast cancer sample4--see VAR_0361212 T S mis40--------
    rs738860801,2
    C,F--186508210(+) TGAATG/ATTCGG 2 -- int13Minor allele frequency- A:0.01WA EU 1437
    rs2004824261,2
    --186508213(+) ATGTTC/TGGTAT 2 -- int10--------
    rs1449484981,2
    C--186508214(+) TGTTCA/GGTATT 2 -- int10--------
    rs22347511,2
    C,F--186508247(-) AGTGT-/TATGTC 2 -- int12Minor allele frequency- T:0.17NA NS 266
    rs1909470911,2
    C--186508268(+) GCCCCC/TGTGCC 2 -- int10--------
    rs39171401,2
    C,F--186508269(-) GGGCAC/TGGGGG 2 -- int11Minor allele frequency- T:0.01NS 132
    rs2667591,2
    C,F,O,A,H--186508312(+) ACTTTT/CCTGGG 2 -- int136Minor allele frequency- C:0.49EA NA NS MN WA CSA 3148
    rs1824517591,2
    --186508324(+) AGGCTG/TTGGGA 2 -- int10--------
    rs1448224501,2
    --186508333(+) GAGAAC/TGGAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for RFC4 (186507669 - 186524847 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RFC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1293846CNV Deletion17803354
    esv34136CNV Loss18971310
    nsv10365CNV Loss18304495
    nsv526938CNV Gain19592680
    dgv1541e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RFC4
    DNA2.0 Custom Variant and Variant Library Synthesis for RFC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 102577    OMIM disorders: --


    Find genes that share disorders with RFC4           About GenesLikeMe

    Genetic Association Database (GAD): RFC4
    Human Genome Epidemiology (HuGE) Navigator: RFC4 (7 documents)

    Export disorders for RFC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RFC4 gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with RFC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    2. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PubMed id 20226869)1, 4 Thyagarajan B....Arora M. (Biol. Blood Marrow Transplant. 2010)
    3. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PubMed id 20574454)1, 4 Arora M....Thyagarajan B. (Leukemia 2010)
    4. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Purification and characterization of human DNA damage checkpoint Rad complexes. (PubMed id 11572977)1, 2 Lindsey-Boltz L.A.... Sancar A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    7. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PubMed id 7774928)1, 3 Okumura K....Ozawa K. (Genomics 1995)
    8. Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells. (PubMed id 1351677)1, 2 Chen M.... Hurwitz J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    9. Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins. (PubMed id 23537643)1 Liang C....Zhang L. (Biochem. Biophys. Res. Commun. 2013)
    10. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5984 HGNC: 9972 AceView: RFC4 Ensembl:ENSG00000163918 euGenes: HUgn5984
    ECgene: RFC4 Kegg: 5984 H-InvDB: RFC4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RFC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RFC4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rfc4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RFC4 gene:
    Search GeneIP for patents involving RFC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RFC4   OriGene RNAi products in human, mouse, rat for RFC4  
     OriGene qPCR primer pairs and template standards for RFC4   OriGene Protein Over-expression Lysate for RFC4  
     OriGene MassSpec something-or-other for RFC4   OriGene clones in human, mouse for RFC4  
     OriGene qSTAR qPCR primer pairs in human, mouse for RFC4   OriGene Purified Protein for RFC4  
     OriGene ORF clones in mouse, rat for RFC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RFC4   OriGene Custom Protein Services for RFC4  

     
     
     Block miRNA regulation of human, mouse, rat RFC4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RFC4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFC4 Predesigned siRNA for gene silencing in human, mouse, rat RFC4
     QuantiFast Probe-based Assays in human, mouse, rat RFC4 QuantiTect SYBR Green Assays in human, mouse, rat RFC4
     Custom PCR Arrays for RFC4 Search Chromatin IP Primers for RFC4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFC4  GeneGlobe Interaction Network for RFC4
     Regulatory tfbs in RFC4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RFC4 GenScript cDNA clones with any tag delivered in your preferred vector for RFC4
     GenScript Custom Assay Services for RFC4 GenScript Custom overexpressing Cell Line Services for RFC4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RFC4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RFC4 antibodies
     RFC4 proteins
     RFC4 lysates
     Antibodies for RFC4
     See all of Abcam's Antibodies, Kits and Proteins for RFC4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RFC4
     Antibodies for RFC4
     ELISAs for RFC4
     CLIAs for RFC4



     Browse ESI BIO Cell Lines and PureStem Progenitors for RFC4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RFC4
     SwitchGear Promoter luciferase reporter plasmids for RFC4
     ThermoFisher Antibody for RFC4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RFC4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RFC4
     LSBio Antibodies in human, mouse, rat for RFC4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RFC4
      Search eBioscience for proteins for RFC4
      Search eBioscience for elisas for RFC4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RFC4 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4