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Aliases for RFC4 Gene

Aliases for RFC4 Gene

  • Replication Factor C (Activator 1) 4, 37kDa 2 3
  • Activator 1 37 KDa Subunit 2 3 4
  • A1 37 KDa Subunit 2 3 4
  • Replication Factor C 37 KDa Subunit 3 4
  • Activator 1 Subunit 4 3 4
  • RF-C 37 KDa Subunit 3 4
  • RFC 37 KDa Subunit 2 3
  • RFC37 3 4
  • Replication Factor C (Activator 1) 4 (37kD) 2
  • Replication Factor C Subunit 4 3
  • A1 3

External Ids for RFC4 Gene

Previous GeneCards Identifiers for RFC4 Gene

  • GC03M183282
  • GC03M187764
  • GC03M187909
  • GC03M187828
  • GC03M187990
  • GC03M186507
  • GC03M183917

Summaries for RFC4 Gene

Entrez Gene Summary for RFC4 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RFC4 Gene

RFC4 (Replication Factor C (Activator 1) 4, 37kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for RFC4 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template

Gene Wiki entry for RFC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFC4 Gene

Genomics for RFC4 Gene

Regulatory Elements for RFC4 Gene

Genomic Location for RFC4 Gene

Start:
186,789,880 bp from pter
End:
186,807,058 bp from pter
Size:
17,179 bases
Orientation:
Minus strand

Genomic View for RFC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFC4 Gene

Proteins for RFC4 Gene

  • Protein details for RFC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35249-RFC4_HUMAN
    Recommended name:
    Replication factor C subunit 4
    Protein Accession:
    P35249
    Secondary Accessions:
    • B4DM41
    • D3DNV2
    • Q6FHX7

    Protein attributes for RFC4 Gene

    Size:
    363 amino acids
    Molecular mass:
    39682 Da
    Quaternary structure:
    • Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.
    Miscellaneous:
    • Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP

    Alternative splice isoforms for RFC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFC4 Gene

Proteomics data for RFC4 Gene at MOPED

Post-translational modifications for RFC4 Gene

  • Ubiquitination at Lys64 and Lys240
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RFC4 Gene

Domains for RFC4 Gene

Gene Families for RFC4 Gene

HGNC:
  • AATP :ATPases / AAA-type

Suggested Antigen Peptide Sequences for RFC4 Gene

Graphical View of Domain Structure for InterPro Entry

P35249

UniProtKB/Swiss-Prot:

RFC4_HUMAN :
  • P35249
Family:
  • Belongs to the activator 1 small subunits family.
genes like me logo Genes that share domains with RFC4: view

Function for RFC4 Gene

Molecular function for RFC4 Gene

GENATLAS Biochemistry: replication factor C4,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP dependent,required to assemble PCNA and polymerase delta on the DNA template
UniProtKB/Swiss-Prot Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template

Gene Ontology (GO) - Molecular Function for RFC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003689 contributes_to DNA clamp loader activity IBA --
GO:0005515 protein binding IPI 15655353
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RFC4: view

Phenotypes for RFC4 Gene

genes like me logo Genes that share phenotypes with RFC4: view

miRNA for RFC4 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RFC4 Gene

Localization for RFC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RFC4 Gene COMPARTMENTS Subcellular localization image for RFC4 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RFC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005663 DNA replication factor C complex IDA 9488738
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RFC4: view

Pathways for RFC4 Gene

genes like me logo Genes that share pathways with RFC4: view

Pathways by source for RFC4 Gene

Gene Ontology (GO) - Biological Process for RFC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
GO:0006260 DNA replication TAS --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with RFC4: view

Compounds for RFC4 Gene

(1) Novoseek inferred chemical compound relationships for RFC4 Gene

Compound -log(P) Hits PubMed IDs
atp 37.1 2
genes like me logo Genes that share compounds with RFC4: view

Transcripts for RFC4 Gene

Unigene Clusters for RFC4 Gene

Replication factor C (activator 1) 4, 37kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFC4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for RFC4 Gene

GeneLoc Exon Structure for
RFC4
ECgene alternative splicing isoforms for
RFC4

Expression for RFC4 Gene

mRNA expression in normal human tissues for RFC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFC4 Gene

SOURCE GeneReport for Unigene cluster for RFC4 Gene Hs.732098

genes like me logo Genes that share expressions with RFC4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RFC4 Gene

Orthologs for RFC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RFC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFC4 35
  • 99.54 (n)
  • 99.45 (a)
RFC4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RFC4 35
  • 91.57 (n)
  • 96.43 (a)
RFC4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFC4 35
  • 90.98 (n)
  • 95.86 (a)
RFC4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rfc4 35
  • 87.05 (n)
  • 91.18 (a)
Rfc4 16
Rfc4 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RFC4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RFC4 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rfc4 35
  • 86.41 (n)
  • 91.46 (a)
chicken
(Gallus gallus)
Aves RFC4 35
  • 76 (n)
  • 84.31 (a)
RFC4 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RFC4 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia RFC2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rfc4 35
  • 75.05 (n)
  • 84.08 (a)
Str.2301 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5941 35
zebrafish
(Danio rerio)
Actinopterygii rfc4 35
  • 66.57 (n)
  • 75.71 (a)
rfc4 36
  • 81 (a)
OneToMany
RFC4 (2 of 2) 36
  • 72 (a)
OneToMany
wufb82e02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003093 35
  • 54.27 (n)
  • 55.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8142 35
  • 52.76 (n)
  • 55.14 (a)
CG8142 36
  • 53 (a)
OneToOne
CG8142 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea rfc-4 36
  • 42 (a)
OneToOne
rfc-4 37
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR422W 35
  • 53.73 (n)
  • 51.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFC2 35
  • 54.96 (n)
  • 54.55 (a)
RFC2 36
  • 50 (a)
OneToOne
RFC2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13992g 35
  • 54.63 (n)
  • 52.16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB1968 35
  • 57.66 (n)
  • 57.14 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5404 35
corn
(Zea mays)
Liliopsida Zm.2942 35
rice
(Oryza sativa)
Liliopsida Os.276 35
Os12g0176500 35
  • 56.35 (n)
  • 55 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6784 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02687 35
  • 53.23 (n)
  • 54.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rfc2 35
  • 54.12 (n)
  • 54.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8604 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToOne
Species with no ortholog for RFC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RFC4 Gene

ENSEMBL:
Gene Tree for RFC4 (if available)
TreeFam:
Gene Tree for RFC4 (if available)

Paralogs for RFC4 Gene

Selected SIMAP similar genes for RFC4 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with RFC4: view

No data available for Paralogs for RFC4 Gene

Variants for RFC4 Gene

Sequence variations from dbSNP and Humsavar for RFC4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs169109 -- 186,808,009(+) tccca(C/G)ctact upstream-variant-2KB
rs187868 -- 186,791,728(-) ATTGC(C/T)GGGGT reference, synonymous-codon
rs189717 -- 186,808,388(+) tttat(A/G)aaggc upstream-variant-2KB
rs266727 -- 186,806,973(-) TTAGA(A/G)GTAAA upstream-variant-2KB
rs266728 -- 186,805,512(+) CCATC(G/T)CGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFC4 Gene

Variant ID Type Subtype PubMed ID
dgv1541e1 CNV Complex 17122850
esv34136 CNV Loss 18971310
nsv10365 CNV Loss 18304495
nsv526938 CNV Gain 19592680
esv1293846 CNV Deletion 17803354

Relevant External Links for RFC4 Gene

HapMap Linkage Disequilibrium report
RFC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFC4 Gene

Disorders for RFC4 Gene

Relevant External Links for RFC4

Genetic Association Database (GAD)
RFC4
Human Genome Epidemiology (HuGE) Navigator
RFC4
genes like me logo Genes that share disorders with RFC4: view

No data available for UniProtKB/Swiss-Prot for RFC4 Gene

Publications for RFC4 Gene

  1. Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells. (PMID: 1351677) Chen M. … Hurwitz J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4
  2. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PMID: 7774928) Okumura K. … Ozawa K. (Genomics 1995) 2 3
  3. Purification and characterization of human DNA damage checkpoint Rad complexes. (PMID: 11572977) Lindsey-Boltz L.A. … Sancar A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PMID: 20226869) Thyagarajan B. … Arora M. (Biol. Blood Marrow Transplant. 2010) 3 48

Products for RFC4 Gene

Sources for RFC4 Gene

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