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Aliases for RFC3 Gene

Aliases for RFC3 Gene

  • Replication Factor C Subunit 3 2 3 5
  • A1 38 KDa Subunit 2 3 4
  • Replication Factor C (Activator 1) 3, 38kDa 2 3
  • Replication Factor C 38 KDa Subunit 3 4
  • Activator 1 38 KDa Subunit 3 4
  • Activator 1 Subunit 3 3 4
  • RF-C 38 KDa Subunit 3 4
  • RFC, 38 KD Subunit 2 3
  • RFC38 3 4
  • Replication Factor C (Activator 1) 3 (38kD) 2

External Ids for RFC3 Gene

Previous GeneCards Identifiers for RFC3 Gene

  • GC13P032378
  • GC13P028378
  • GC13P033328
  • GC13P032190
  • GC13P033290
  • GC13P034392
  • GC13P015203

Summaries for RFC3 Gene

Entrez Gene Summary for RFC3 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for RFC3 Gene

RFC3 (Replication Factor C Subunit 3) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Chromosome Maintenance. GO annotations related to this gene include ATPase activity and DNA clamp loader activity.

UniProtKB/Swiss-Prot for RFC3 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Gene Wiki entry for RFC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFC3 Gene

Genomics for RFC3 Gene

Regulatory Elements for RFC3 Gene

Enhancers for RFC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F033270 1.6 FANTOM5 Ensembl ENCODE 10.8 -539.5 -539469 16.6 PKNOX1 ZNF133 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 YY1 SLC30A9 N4BP2L2 STARD13-AS RFC3 KL STARD13 LOC105370154
GH13F033202 1.3 FANTOM5 ENCODE 11.6 -612.2 -612186 7.7 HDGF TBP PKNOX1 WRNIP1 ZFP64 SIN3A RAD21 ZBTB40 RARA YY1 STARD13 RFC3 STARD13-AS KL N4BP2L2 LOC105370154
GH13F033015 0.8 ENCODE 13.5 -801.4 -801415 3.3 TBP CTCF USF1 SUZ12 EBF1 RAD21 POLR2A NFYB ZNF143 SMC3 RFC3 N4BP2L2 STARD13 KL STARD13-IT1
GH13F033859 0.7 ENCODE 14.4 +41.9 41857 1.5 KLF1 KLF17 ATF2 ZEB1 ATF3 SCRT2 FOS ZNF24 ZNF548 CREM RFC3 PIR39338 PIR43424
GH13F033797 0.8 Ensembl ENCODE 11.6 -20.1 -20142 1.0 JUND IKZF1 EED NR3C1 FOS RFC3 STARD13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RFC3 on UCSC Golden Path with GeneCards custom track

Promoters for RFC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000274505 452 2200 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5

Genomic Location for RFC3 Gene

Chromosome:
13
Start:
33,818,049 bp from pter
End:
33,973,946 bp from pter
Size:
155,898 bases
Orientation:
Plus strand

Genomic View for RFC3 Gene

Genes around RFC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFC3 Gene

Proteins for RFC3 Gene

  • Protein details for RFC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40938-RFC3_HUMAN
    Recommended name:
    Replication factor C subunit 3
    Protein Accession:
    P40938
    Secondary Accessions:
    • C9JU95
    • O15252
    • Q5W0E8

    Protein attributes for RFC3 Gene

    Size:
    356 amino acids
    Molecular mass:
    40556 Da
    Quaternary structure:
    • Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.

    Alternative splice isoforms for RFC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RFC3 Gene

Post-translational modifications for RFC3 Gene

  • Ubiquitination at Lys 20, Lys 170, Lys 202, and Lys 225
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RFC3 Gene

Domains & Families for RFC3 Gene

Gene Families for RFC3 Gene

Protein Domains for RFC3 Gene

Suggested Antigen Peptide Sequences for RFC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40938

UniProtKB/Swiss-Prot:

RFC3_HUMAN :
  • Belongs to the activator 1 small subunits family.
Family:
  • Belongs to the activator 1 small subunits family.
genes like me logo Genes that share domains with RFC3: view

Function for RFC3 Gene

Molecular function for RFC3 Gene

GENATLAS Biochemistry:
replication factor C3,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP dependent,required to assemble PCNA and polymerase delta on the DNA template
UniProtKB/Swiss-Prot Function:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Gene Ontology (GO) - Molecular Function for RFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IEA,IDA 9488738
GO:0003689 DNA clamp loader activity TAS 9488738
GO:0005515 protein binding IPI 9488738
GO:0016887 contributes_to ATPase activity IDA 9488738
GO:0043142 contributes_to single-stranded DNA-dependent ATPase activity IDA 12930902
genes like me logo Genes that share ontologies with RFC3: view
genes like me logo Genes that share phenotypes with RFC3: view

Animal Model Products

miRNA for RFC3 Gene

miRTarBase miRNAs that target RFC3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RFC3 Gene

Localization for RFC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFC3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFC3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005663 DNA replication factor C complex TAS 7774928
GO:0031390 Ctf18 RFC-like complex IDA 12930902
genes like me logo Genes that share ontologies with RFC3: view

Pathways & Interactions for RFC3 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 DNA Double-Strand Break Repair
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Homologous DNA Pairing and Strand Exchange
genes like me logo Genes that share pathways with RFC3: view

Gene Ontology (GO) - Biological Process for RFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination TAS --
GO:0000731 DNA synthesis involved in DNA repair TAS 9488738
GO:0006260 DNA replication TAS --
GO:0006271 DNA strand elongation involved in DNA replication TAS 7774928
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with RFC3: view

No data available for SIGNOR curated interactions for RFC3 Gene

Transcripts for RFC3 Gene

Unigene Clusters for RFC3 Gene

Replication factor C (activator 1) 3, 38kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFC3 Gene

No ASD Table

Relevant External Links for RFC3 Gene

GeneLoc Exon Structure for
RFC3
ECgene alternative splicing isoforms for
RFC3

Expression for RFC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RFC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RFC3 Gene

This gene is overexpressed in Breast (35.7), Bone (11.6), and Lung (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RFC3 Gene



Protein tissue co-expression partners for RFC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RFC3 Gene:

RFC3

SOURCE GeneReport for Unigene cluster for RFC3 Gene:

Hs.115474
genes like me logo Genes that share expression patterns with RFC3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RFC3 Gene

Orthologs for RFC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RFC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RFC3 34 35
  • 99.25 (n)
oppossum
(Monodelphis domestica)
Mammalia RFC3 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RFC3 34 35
  • 94.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RFC3 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RFC3 34 35
  • 93.73 (n)
mouse
(Mus musculus)
Mammalia Rfc3 34 16 35
  • 87.83 (n)
rat
(Rattus norvegicus)
Mammalia Rfc3 34
  • 85.21 (n)
chicken
(Gallus gallus)
Aves RFC3 34 35
  • 80.71 (n)
lizard
(Anolis carolinensis)
Reptilia RFC3 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rfc3 34
  • 77.25 (n)
zebrafish
(Danio rerio)
Actinopterygii rfc3 34 35
  • 73.41 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6760 34
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD06837 36
  • 60 (a)
RfC38 34 35
  • 58.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009047 34
  • 58.69 (n)
worm
(Caenorhabditis elegans)
Secernentea rfc-3 36 34 35
  • 57.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFC5 34 35 37
  • 50.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL303C 34
  • 49.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12221g 34
  • 48.94 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2775 34
  • 56.81 (n)
soybean
(Glycine max)
eudicotyledons Gma.8866 34
rice
(Oryza sativa)
Liliopsida Os03g0792600 34
  • 55.94 (n)
Os.28012 34
barley
(Hordeum vulgare)
Liliopsida Hv.2823 34
corn
(Zea mays)
Liliopsida Zm.5155 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8435 35
  • 71 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rfc5 34
  • 56.35 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06769 34
  • 55.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8470 34
Species where no ortholog for RFC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RFC3 Gene

ENSEMBL:
Gene Tree for RFC3 (if available)
TreeFam:
Gene Tree for RFC3 (if available)

Paralogs for RFC3 Gene

Pseudogenes.org Pseudogenes for RFC3 Gene

genes like me logo Genes that share paralogs with RFC3: view

No data available for Paralogs for RFC3 Gene

Variants for RFC3 Gene

Sequence variations from dbSNP and Humsavar for RFC3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10219819 -- 33,841,346(+) tactt(C/G)tgtag intron-variant
rs10220053 -- 33,890,108(+) CCTTA(C/T)GACCT intron-variant
rs10220198 -- 33,883,117(+) TTCTC(A/T)AAAAT intron-variant
rs10220208 -- 33,950,780(+) TCTCT(C/G)TCTTT intron-variant
rs1041091 -- 33,830,150(-) GTTCA(C/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFC3 Gene

Variant ID Type Subtype PubMed ID
esv2504202 CNV deletion 19546169
esv2747249 CNV deletion 23290073
esv2747250 CNV deletion 23290073
esv3450965 CNV duplication 20981092
esv3631745 CNV loss 21293372
esv3631746 CNV gain 21293372
nsv1054003 CNV gain 25217958
nsv477781 CNV novel sequence insertion 20440878
nsv527943 CNV loss 19592680
nsv528193 CNV loss 19592680
nsv995 CNV insertion 18451855
nsv996 CNV insertion 18451855

Variation tolerance for RFC3 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RFC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RFC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFC3 Gene

Disorders for RFC3 Gene

Relevant External Links for RFC3

Genetic Association Database (GAD)
RFC3
Human Genome Epidemiology (HuGE) Navigator
RFC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RFC3

No disorders were found for RFC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFC3 Gene

Publications for RFC3 Gene

  1. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. (PMID: 20061627) Heinzen E.L. … Goldstein D.B. (J. Alzheimers Dis. 2010) 3 46 64
  2. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PMID: 20226869) Thyagarajan B. … Arora M. (Biol. Blood Marrow Transplant. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PMID: 20574454) Arora M. … Thyagarajan B. (Leukemia 2010) 3 46 64

Products for RFC3 Gene

Sources for RFC3 Gene

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