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RFC3 Gene

protein-coding   GIFtS: 63
GCID: GC13P034392

Replication Factor C (Activator 1) 3, 38kDa

(Previous name: replication factor C (activator 1) 3 (38kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Replication Factor C (Activator 1) 3, 38kDa1 2     RF-C 38 KDa Subunit2 3
A1 38 KDa Subunit1 2 3     38 KD Subunit1
Activator 1 38 KDa Subunit2 3     RFC1
Activator 1 Subunit 32 3     Replication Factor C (Activator 1) 3 (38kD)1
Replication Factor C 38 KDa Subunit2 3     Replication Factor C Subunit 32
RFC382 3     RFC, 38 KD Subunit2

External Ids:    HGNC: 99711   Entrez Gene: 59832   Ensembl: ENSG000001331197   OMIM: 6004055   UniProtKB: P409383   

Export aliases for RFC3 gene to outside databases

Previous GC identifers: GC13P032378 GC13P028378 GC13P033328 GC13P032190 GC13P033290 GC13P015203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RFC3 Gene:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory
proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1,
is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the
38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex
that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct
isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for RFC3 Gene:
RFC3 (replication factor C (activator 1) 3, 38kDa) is a protein-coding gene. Diseases associated with RFC3 include graft versus host disease, and esophagitis. GO annotations related to this gene include DNA clamp loader activity and nucleotide binding.

UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

Gene Wiki entry for RFC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the RFC3 gene promoter:
         MyoD   Nkx2-5   NF-kappaB   Roaz   MZF-1   AREB6   COMP1   NF-kappaB2   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFC3 promoter sequence
   Search Chromatin IP Primers for RFC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RFC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.2   Ensembl cytogenetic band:  13q13.2   HGNC cytogenetic band: 13q13.2

RFC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFC3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P034392:  view genomic region     (about GC identifiers)

Start:
34,392,186 bp from pter      End:
34,540,695 bp from pter
Size:
148,510 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938 (See protein sequence)
Recommended Name: Replication factor C subunit 3  
Size: 356 amino acids; 40556 Da
Subunit: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with
RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not
stimulated by PCNA
Secondary accessions: C9JU95 O15252 Q5W0E8
Alternative splicing: 2 isoforms:  P40938-1   P40938-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RFC3: NX_P40938

Explore proteomics data for RFC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20, Lys170, Lys202, Lys225
  • Modification sites at PhosphoSitePlus

  • See RFC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002906.1  NP_853536.2  

    ENSEMBL proteins: 
     ENSP00000369411   ENSP00000401001  
    Reactome Protein details: P40938

    RFC3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RFC3
    OriGene Protein Over-expression Lysate for RFC3
    OriGene MassSpec for RFC3
    OriGene Custom Protein Services for RFC3
    GenScript Custom Purified and Recombinant Proteins Services for RFC3
    Novus Biologicals RFC3 Proteins
    Novus Biologicals RFC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFC3

    RFC3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RFC3
    Novus Biologicals RFC3 Antibodies
    Abcam antibodies for RFC3
    Cloud-Clone Corp. Antibodies for RFC3
    ThermoFisher Antibody for RFC3
    LSBio Antibodies in human, mouse, rat for RFC3

    RFC3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RFC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RFC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RFC3
    Cloud-Clone Corp. CLIAs for RFC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    4 InterPro protein domains:
     IPR008921 DNA_pol3_clamp-load_cplx_C
     IPR013748 Rep_factorC_C_dom
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P40938

    ProtoNet protein and cluster: P40938

    UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938
    Similarity: Belongs to the activator 1 small subunits family


    RFC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFC3_HUMAN, P40938
    Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
    accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

         Genatlas biochemistry entry for RFC3:
    replication factor C3,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP
    dependent,required to assemble PCNA and polymerase delta on the DNA template

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003677contributes to DNA binding IDA9488738
    GO:0003689DNA clamp loader activity TAS9488738
    GO:0003887DNA-directed DNA polymerase activity ----
    GO:0005515protein binding IPI9488738
         
    RFC3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RFC3:
     Increased cell death in HCT116  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RFC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RFC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RFC3:
    hsa-mir-93-5p (MIRT048816), hsa-mir-20a-5p (MIRT050570), hsa-mir-124-3p (MIRT022240)

    Block miRNA regulation of human, mouse, rat RFC3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RFC3:
    hsa-miR-2052 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidRFC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RFC3
    Predesigned siRNA for gene silencing in human, mouse, rat RFC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RFC3

    Clone
    Products:
         
    OriGene clones in human, mouse for RFC3 (see all 15)
    OriGene ORF clones in mouse, rat for RFC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFC3 (NM_181558)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RFC3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RFC3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFC3_HUMAN, P40938: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005663DNA replication factor C complex TAS7774928
    GO:0009360DNA polymerase III complex ----

    RFC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RFC3 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Telomere C-strand (Lagging Strand) Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Cell cycle Transition and termination of DNA replication0.43
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Polymerase switching on the C-strand of the telomere0.00
    Telomere C-strand (Lagging Strand) Synthesis0.79
    Lagging Strand Synthesis0.00
    Extension of Telomeres0.79
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.00
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Nucleotide Excision Repair Pathway0.48
    Nucleotide excision repair0.69
    3DNA strand elongation
    DNA strand elongation0.63
    DNA replication0.63
    4CDK-mediated phosphorylation and removal of Cdc6
    Synthesis of DNA0.92
    S Phase0.78
    DNA Replication0.92
    Cell Cycle Checkpoints0.58
    5DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    DNA Repair0.45
    Nucleotide Excision Repair0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RFC3
        Mismatch Repair in Eukaryotes
    Nucleotide Excision Repair Pathway

    1 GeneGo (Thomson Reuters) Pathway for RFC3
        Cell cycle Transition and termination of DNA replication

    3 BioSystems Pathways for RFC3
        Gastric cancer network 2
    DNA Replication
    RB in Cancer

    5 Reactome Pathways for RFC3
        Polymerase switching on the C-strand of the telomere
    Repair synthesis for gap-filling by DNA polymerase in TC-NER
    Activation of ATR in response to replication stress
    Polymerase switching
    Repair synthesis of patch ~27-30 bases long by DNA polymerase


    3 Kegg Pathways  (Kegg details for RFC3):
        DNA replication
    Nucleotide excision repair
    Mismatch repair


    RFC3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RFC3
    Interactions:

        GeneGlobe Interaction Network for RFC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RFC3 (P409381, 2, 3 ENSP000003694114) via UniProtKB, MINT, STRING, and/or I2D (see all 951)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BUB1O436832, 3, ENSP000003025304MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000302530
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000354720
    MESDC2Q146962, 3, ENSP000002617584MINT-8262958 I2D: score=2 STRING: ENSP00000261758
    BTAF1O149812, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0000731DNA synthesis involved in DNA repair TAS9488738
    GO:0006200ATP catabolic process IDA9488738

    RFC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RFC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RFC3 gene (2 alternative transcripts): 
    NM_002915.3  NM_181558.2  

    Unigene Cluster for RFC3:

    Replication factor C (activator 1) 3, 38kDa
    Hs.115474  [show with all ESTs]
    Unigene Representative Sequence: AK128459
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380071(uc001uuz.3) ENST00000434425(uc010ted.1 uc001uva.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RFC3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RFC3:
    hsa-miR-2052 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidRFC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RFC3
    Predesigned siRNA for gene silencing in human, mouse, rat RFC3
    Clone
    Products:
         
    OriGene clones in human, mouse for RFC3 (see all 15)
    OriGene ORF clones in mouse, rat for RFC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFC3 (NM_181558)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RFC3
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFC3
      QuantiTect SYBR Green Assays in human, mouse, rat RFC3
      QuantiFast Probe-based Assays in human, mouse, rat RFC3

    Additional mRNA sequence: 

    AK128459.1 AK222572.1 AK296527.1 AK312544.1 BC000149.2 BT019668.1 L07541.1 

    11 DOTS entries:

    DT.456429  DT.100792521  DT.101972559  DT.100792524  DT.95276763  DT.120789338  DT.91767579  DT.100792519 
    DT.100792522  DT.120789343  DT.97791965 

    Selected AceView cDNA sequences (see all 205):

    BU195203 NM_002915 AW594149 CR598980 AA486413 BU743042 AI354563 AA424909 
    N46759 BC000149 AA506002 AW675027 AA807174 AA455759 AA460423 BG284608 
    AA910425 AA806873 AA306309 BP338383 BQ022285 AA443939 H01930 BQ439634 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RFC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RFC3 Expression
    About this image

    RFC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RFC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115474
        Custom PCR Arrays for RFC3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RFC3
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RFC3
    QuantiTect SYBR Green Assays in human, mouse, rat RFC3
    QuantiFast Probe-based Assays in human, mouse, rat RFC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RFC3 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfc31 , 5 replication factor C (activator 1) 31, 5 87.83(n)1
    97.19(a)1
      5 (90.18 cM)5
    692631  NM_027009.21  NP_081285.11 
     1516427565 
    chicken
    (Gallus gallus)
    Aves RFC31 replication factor C (activator 1) 3, 38kDa 80.71(n)
    89.33(a)
      418907  NM_001006276.1  NP_001006276.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFC36
    replication factor C (activator 1) 3, 38kDa
    90(a)
    1 ↔ 1
    3(183103239-183123856)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA791108.12   -- 77.48(n)    CA791108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC042327.12   -- 75.65(n)    BC042327.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD068373
    RfC381
    DNA clamp loader3
    Replication factor C 38kD subunit1
    60(a)3
    58.74(n)1
    60.17(a)1
      32D43
    345501  NM_135650.21  NP_609494.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rfc-31 , 3 Human activator 1 38 KD subunit like3
    rfc-31
    53(a)3
    57.67(n)1
    54.84(a)1
      IV(13095940-13097109)3
    1782591  NM_070116.61  NP_502517.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RFC5(YBR087W)4
    RFC51
    Subunit of heteropentameric Replication factor C (RF-C), more4
    RFC51
    50.39(n)1
    45.29(a)1
      2(423765-424829)4
    8523831, 4  NP_009644.31  NP_009644.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27751 EMB2775 56.81(n)
    53.91(a)
      832836  NM_122656.4  NP_198126.1 
    rice
    (Oryza sativa)
    Liliopsida Os.280122 Oryza sativa (japonica cultivar-group) OsRFC5 mRNA more 73.68(n)    AK103751.1 


    ENSEMBL Gene Tree for RFC3 (if available)
    TreeFam Gene Tree for RFC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RFC3 gene

    RFC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RFC3
    PGOHUM00000237580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RFC3 (see all 3107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497327161,2
    C--15364100(+) TTTTT-/TAACTG 1 -- int10--------
    rs790779161,2
    C,F--34390283(+) CTACAT/CGGGAG 2 -- us2k15Minor allele frequency- C:0.25WA NA CSA EA 245
    rs31355211,2
    C,F,H--34390636(+) AATTTC/GAAATA 2 -- us2k18Minor allele frequency- G:0.18NS EA CSA WA 771
    rs1511623421,2
    --34390952(+) ACTTAC/TTTCCA 2 -- us2k10--------
    rs31355221,2
    C,F,H--34391200(+) gaaacA/Gtagtc 2 -- us2k15Minor allele frequency- G:0.00NS EA 588
    rs31355231,2
    C,F,H--34391277(+) TTCTCG/AAGAAC 2 -- us2k119Minor allele frequency- A:0.15NS EA NA WA CSA 2402
    rs31355241,2
    H--34391296(+) AATCTT/AATACT 2 -- us2k15Minor allele frequency- A:0.00NS EA 586
    rs1852074751,2
    --34391382(+) ATTGAC/TTAATA 2 -- us2k10--------
    rs31355251,2
    C,F,H--34391403(+) AGGCAC/ACTTGG 2 -- us2k1 tfbs310Minor allele frequency- A:0.05NS MN EA NA WA 1058
    rs797127271,2
    C,F--34391429(+) TATATT/CTGGAA 2 -- us2k11Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for RFC3 (34392186 - 34540695 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RFC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747250CNV Deletion23290073
    esv2504202CNV Deletion19546169
    esv2747249CNV Deletion23290073
    nsv995CNV Insertion18451855
    nsv996CNV Insertion18451855
    nsv528193CNV Loss19592680
    nsv527943CNV Loss19592680
    nsv899975CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RFC3
    DNA2.0 Custom Variant and Variant Library Synthesis for RFC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600405    OMIM disorders: --

    8 diseases for RFC3:    
    About MalaCards
    graft versus host disease    esophagitis    adenocarcinoma    colorectal cancer
    obesity    alzheimer's disease    malaria    breast cancer


    RFC3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RFC3
    Human Genome Epidemiology (HuGE) Navigator: RFC3 (10 documents)

    Export disorders for RFC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RFC3 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with RFC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PubMed id 20226869)1, 4 Thyagarajan B....Arora M. (Biol. Blood Marrow Transplant. 2010)
    2. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PubMed id 20574454)1, 4 Arora M....Thyagarajan B. (Leukemia 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. (PubMed id 20061627)1, 4 Heinzen E.L....Goldstein D.B. (J. Alzheimers Dis. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Purification and characterization of human DNA damage checkpoint Rad complexes. (PubMed id 11572977)1, 2 Lindsey-Boltz L.A.... Sancar A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2 Rauen M.... Karnitz L.M. (J. Biol. Chem. 2000)
    10. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PubMed id 7774928)1, 3 Okumura K....Ozawa K. (Genomics 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5983 HGNC: 9971 AceView: RFC3 Ensembl:ENSG00000133119 euGenes: HUgn5983
    ECgene: RFC3 Kegg: 5983 H-InvDB: RFC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RFC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RFC3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rfc3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RFC3 gene:
    Search GeneIP for patents involving RFC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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