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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFC3 Gene

protein-coding   GIFtS: 62
GCID: GC13P034392

Replication Factor C (Activator 1) 3, 38kDa

(Previous name: replication factor C (activator 1) 3 (38kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Replication Factor C (Activator 1) 3, 38kDa1 2     RF-C 38 KDa Subunit2 3
A1 38 KDa Subunit1 2 3     38 KD Subunit1
Activator 1 38 KDa Subunit2 3     RFC1
Activator 1 Subunit 32 3     Replication Factor C (Activator 1) 3 (38kD)1
Replication Factor C 38 KDa Subunit2 3     Replication Factor C Subunit 32
RFC382 3     RFC, 38 KD Subunit2

External Ids:    HGNC: 99711   Entrez Gene: 59832   Ensembl: ENSG000001331197   OMIM: 6004055   UniProtKB: P409383   

Export aliases for RFC3 gene to outside databases

Previous GC identifers: GC13P032378 GC13P028378 GC13P033328 GC13P032190 GC13P033290 GC13P015203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RFC3 Gene:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory
proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1,
is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the
38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex
that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct
isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for RFC3 Gene: 
RFC3 (replication factor C (activator 1) 3, 38kDa) is a protein-coding gene. Diseases associated with RFC3 include graft versus host disease, and esophageal adenocarcinoma, and among its related super-pathways are Lagging Strand Synthesis and Global Genomic NER (GG-NER). GO annotations related to this gene include DNA clamp loader activity and nucleotide binding.

UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

Gene Wiki entry for RFC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFC3 gene promoter:
         MyoD   Nkx2-5   NF-kappaB   Roaz   MZF-1   AREB6   COMP1   NF-kappaB2   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RFC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.2   Ensembl cytogenetic band:  13q13.2   HGNC cytogenetic band: 13q13.2

RFC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFC3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P034392:  view genomic region     (about GC identifiers)

Start:
34,392,186 bp from pter      End:
34,540,695 bp from pter
Size:
148,510 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938 (See protein sequence)
Recommended Name: Replication factor C subunit 3  
Size: 356 amino acids; 40556 Da
Subunit: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with
RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not
stimulated by PCNA
Subcellular location: Nucleus (Probable)
Secondary accessions: C9JU95 O15252 Q5W0E8
Alternative splicing: 2 isoforms:  P40938-1   P40938-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RFC3: NX_P40938

Explore proteomics data for RFC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40938

  • RFC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RFC3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002906.1  NP_853536.2  

    ENSEMBL proteins: 
     ENSP00000369411   ENSP00000401001  
    Reactome Protein details: P40938
    Human Recombinant Protein Products for RFC3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RFC3
    OriGene Protein Over-expression Lysate for RFC3
    OriGene MassSpec for RFC3 
    OriGene Custom Protein Services for RFC3
    GenScript Custom Purified and Recombinant Proteins Services for RFC3
    Novus Biologicals RFC3 Proteins
    Novus Biologicals RFC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RFC3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005663DNA replication factor C complex TAS7774928
    GO:0009360DNA polymerase III complex ----

    RFC3 for ontologies           About GeneDecksing



    RFC3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RFC3
    GenScript Custom Superior Antibodies Services for RFC3
    Novus Biologicals RFC3 Antibodies
    Abcam antibodies for RFC3
    Cloud-Clone Corp. Antibodies for RFC3 
    ThermoFisher Antibody for RFC3
    LSBio Antibodies in human, mouse, rat for RFC3 

    Assay Products for RFC3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RFC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RFC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RFC3 
    Cloud-Clone Corp. CLIAs for RFC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AATP: ATPases / AAA-type

    4 InterPro protein domains:
     IPR008921 DNA_pol3_clamp-load_cplx_C
     IPR013748 Rep_factorC_C_dom
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P40938

    ProtoNet protein and cluster: P40938

    UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938
    Similarity: Belongs to the activator 1 small subunits family


    RFC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFC3_HUMAN, P40938
    Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
    accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

         Genatlas biochemistry entry for RFC3:
    replication factor C3,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP
    dependent,required to assemble PCNA and polymerase delta on the DNA template

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003677contributes to DNA binding IDA9488738
    GO:0003689DNA clamp loader activity TAS9488738
    GO:0003887DNA-directed DNA polymerase activity ----
    GO:0005515protein binding IPI9488738
         
    RFC3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RFC3:
     Increased cell death in HCT116  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RFC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RFC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RFC3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RFC3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFC3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RFC3:
    hsa-miR-2052 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidRFC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RFC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RFC3
    Sirion Biotech Customized adenovirus for overexpression of RFC3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RFC3 (see all 15)
    OriGene ORF clones in mouse, rat for RFC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFC3 (NM_181558)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC3
    Sirion Biotech Customized lentivirus for stable overexpression of RFC3 
                         Customized lentivirus expression plasmids for stable overexpression of RFC3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RFC3
    Search LifeMap BioReagents cell lines for RFC3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RFC3 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Lagging Strand Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Leading Strand Synthesis0.70
    Gap-filling DNA repair synthesis and ligation in GG-NER0.94
    Polymerase switching0.70
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.94
    Polymerase switching on the C-strand of the telomere0.70
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    DNA strand elongation0.65
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.70
    Nucleotide Excision Repair Pathway0.49
    Nucleotide excision repair0.70
    3Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    4CDK-mediated phosphorylation and removal of Cdc6
    Synthesis of DNA0.79
    DNA Replication0.78
    S Phase0.79
    Cell Cycle Checkpoints0.58
    5Nucleotide Excision Repair
    Nucleotide Excision Repair0.90
    DNA Repair0.46
    Transcription-coupled NER (TC-NER)0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RFC3
        Cell cycle Transition and termination of DNA replacation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RFC3
        Mismatch Repair in Eukaryotes
    Nucleotide Excision Repair Pathway

    1 GeneGo (Thomson Reuters) Pathway for RFC3
        Cell cycle Transition and termination of DNA replication

    2 BioSystems Pathways for RFC3
        Gastric cancer network 2
    DNA Replication

    5/25        Reactome Pathways for RFC3 (see all 25)
        Extension of Telomeres
    Telomere Maintenance
    DNA Repair
    Activation of ATR in response to replication stress
    Leading Strand Synthesis


    3         Kegg Pathways  (Kegg details for RFC3):
        DNA replication
    Nucleotide excision repair
    Mismatch repair


    RFC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/877 Interacting proteins for RFC3 (P409381, 2, 3 ENSP000003694114) via UniProtKB, MINT, STRING, and/or I2D (see all 877)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000354720
    MESDC2Q146962, 3, ENSP000002617584MINT-8262958 I2D: score=2 STRING: ENSP00000261758
    BTAF1O149812, 3MINT-7945693 MINT-7947479 I2D: score=1 
    BUB1O436832, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0000731DNA synthesis involved in DNA repair TAS9488738
    GO:0006200ATP catabolic process IDA9488738

    RFC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RFC3

    Search CenterWatch for drugs/clinical trials and news about RFC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RFC3 gene (2 alternative transcripts): 
    NM_002915.3  NM_181558.2  

    Unigene Cluster for RFC3:

    Replication factor C (activator 1) 3, 38kDa
    Hs.115474  [show with all ESTs]
    Unigene Representative Sequence: AK128459
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380071(uc001uuz.3) ENST00000434425(uc010ted.1 uc001uva.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFC3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RFC3:
    hsa-miR-2052 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidRFC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RFC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFC3
    Clone
    Products:
         
    OriGene clones in human, mouse for RFC3 (see all 15)
    OriGene ORF clones in mouse, rat for RFC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RFC3 (NM_181558)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC3
    Sirion Biotech Customized lentivirus for stable overexpression of RFC3 
                         Customized lentivirus expression plasmids for stable overexpression of RFC3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RFC3
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RFC3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFC3

    Additional mRNA sequence: 

    AK128459.1 AK222572.1 AK296527.1 AK312544.1 BC000149.2 BT019668.1 L07541.1 

    11 DOTS entries:

    DT.456429  DT.100792521  DT.101972559  DT.100792524  DT.95276763  DT.120789338  DT.91767579  DT.100792519 
    DT.100792522  DT.120789343  DT.97791965 

    24/205 AceView cDNA sequences (see all 205):

    BU618419 NM_002915 AV709344 BQ436009 BG284608 BQ022285 BU176632 AA284970 
    AA743418 AI537038 AA506002 AA807174 AI453050 BG106685 CR598980 AA306309 
    AA806873 BG389475 AA486413 BQ439634 BU193565 AA424909 AW673872 H01930 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RFC3 Expression
    About this image


    See RFC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RFC3

    SOURCE GeneReport for Unigene cluster: Hs.115474
        SABiosciences Custom PCR Arrays for RFC3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RFC3
    OriGene qSTAR qPCR primer pairs in human, mouse for RFC3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RFC3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFC3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RFC3 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rfc31 , 5 replication factor C (activator 1) 31, 5 87.83(n)1
    97.19(a)1
      5 (90.18 cM)5
    692631  NM_027009.21  NP_081285.11 
     1516427565 
    chicken
    (Gallus gallus)
    Aves RFC31 replication factor C (activator 1) 3, 38kDa 80.71(n)
    89.33(a)
      418907  NM_001006276.1  NP_001006276.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFC36
    Uncharacterized protein
    90(a)
    1 ↔ 1
    3(183103239-183123856)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA791108.12   -- 77.48(n)    CA791108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC042327.12   -- 75.65(n)    BC042327.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD068373
    RfC381
    DNA clamp loader3
    Replication factor C 38kD subunit1
    60(a)3
    58.74(n)1
    60.17(a)1
      32D43
    345501  NM_135650.21  NP_609494.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rfc-31 , 3 Human activator 1 38 KD subunit like3
    Protein RFC-31
    53(a)3
    57.48(n)1
    54.55(a)1
      IV(13095940-13097109)3
    1782591  NM_070116.51  NP_502517.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RFC5(YBR087W)4
    RFC51
    Subunit of heteropentameric Replication factor C (RF-C), more4
    Rfc5p1
    50.39(n)1
    45.29(a)1
      2(423765-424829)4
    8523831, 4  NP_009644.31  NP_009644.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27751 replication factor C subunit 3/5 56.81(n)
    53.91(a)
      832836  NM_122656.4  NP_198126.1 
    rice
    (Oryza sativa)
    Liliopsida Os.280122 Oryza sativa (japonica cultivar-group) OsRFC5 mRNA more 73.68(n)    AK103751.1 


    ENSEMBL Gene Tree for RFC3 (if available)
    TreeFam Gene Tree for RFC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFC3 gene

    RFC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RFC3
    PGOHUM00000237580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3107 SNPs in RFC3 are shown (see all 3107)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497327161,2
    C--15364100(+) TTTTT-/TAACTG 1 -- int10--------
    rs790779161,2
    C,F--34390283(+) CTACAT/CGGGAG 2 -- us2k15Minor allele frequency- C:0.25WA NA CSA EA 245
    rs31355211,2
    C,F,H--34390636(+) AATTTC/GAAATA 2 -- us2k18Minor allele frequency- G:0.18NS EA CSA WA 771
    rs1511623421,2
    --34390952(+) ACTTAC/TTTCCA 2 -- us2k10--------
    rs31355221,2
    C,F,H--34391200(+) gaaacA/Gtagtc 2 -- us2k15Minor allele frequency- G:0.00NS EA 588
    rs31355231,2
    C,F,H--34391277(+) TTCTCG/AAGAAC 2 -- us2k119Minor allele frequency- A:0.15NS EA NA WA CSA 2402
    rs31355241,2
    H--34391296(+) AATCTT/AATACT 2 -- us2k15Minor allele frequency- A:0.00NS EA 586
    rs1852074751,2
    --34391382(+) ATTGAC/TTAATA 2 -- us2k10--------
    rs31355251,2
    C,F,H--34391403(+) AGGCAC/ACTTGG 2 -- us2k1 tfbs310Minor allele frequency- A:0.05NS MN EA NA WA 1058
    rs797127271,2
    C,F--34391429(+) TATATT/CTGGAA 2 -- us2k11Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for RFC3 (34392186 - 34540695 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RFC3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747250CNV Deletion23290073
    esv2504202CNV Deletion19546169
    esv2747249CNV Deletion23290073
    nsv995CNV Insertion18451855
    nsv996CNV Insertion18451855
    nsv528193CNV Loss19592680
    nsv527943CNV Loss19592680
    nsv899975CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600405    OMIM disorders: --

    6 diseases for RFC3:    About MalaCards
    graft versus host disease    esophageal adenocarcinoma    esophagitis    colorectal cancer
    alzheimer's disease    adenocarcinoma


    RFC3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RFC3
    Human Genome Epidemiology (HuGE) Navigator: RFC3 (10 documents)

    Export disorders for RFC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RFC3 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with RFC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between genetic variants in the base exci sion repair pathway and outcomes after hematopoietic cell transplantations. (PubMed id 20226869)1, 4 Thyagarajan B....Arora M. (2010)
    2. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PubMed id 20574454)1, 4 Arora M....Thyagarajan B. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genome-wide scan of copy number variation in late-onse t Alzheimer's disease. (PubMed id 20061627)1, 4 Heinzen E.L....Goldstein D.B. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Purification and characterization of human DNA damage checkpoint Rad complexes. (PubMed id 11572977)1, 2 Lindsey-Boltz L.A.... Sancar A. (2001)
    9. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2 Rauen M.... Karnitz L.M. (2000)
    10. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PubMed id 7774928)1, 3 Okumura K....Ozawa K. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5983 HGNC: 9971 AceView: RFC3 Ensembl:ENSG00000133119 euGenes: HUgn5983
    ECgene: RFC3 Kegg: 5983 H-InvDB: RFC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RFC3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rfc3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RFC3 gene:
    Search GeneIP for patents involving RFC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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