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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RFC3 Gene

protein-coding   GIFtS: 61
GCID: GC13P034392

replication factor C (activator 1) 3, 38kDa

(Previous name: replication factor C (activator 1) 3 (38kD) )
 Explore 4 diseases affiliated with
RFC3 via our new
 Human Malady Compendium 
Biological research products
for RFC3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Replication Factor C (Activator 1) 3, 38kDa1 2     RF-C 38 KDa Subunit2 3
RFC381 2 3     MGC52761
Activator 1 38 KDa Subunit2 3     Replication Factor C (Activator 1) 3 (38kD)1
Activator 1 Subunit 32 3     Replication Factor C Subunit 32
Replication Factor C 38 KDa Subunit2 3     RFC, 38 KD Subunit2
A1 38 KDa Subunit2 3     

External Ids:    HGNC: 99711   Entrez Gene: 59832   Ensembl: ENSG000001331197   OMIM: 6004055   UniProtKB: P409383   

Export aliases for RFC3 gene to outside databases

Previous GC identifers: GC13P032378 GC13P028378 GC13P033328 GC13P032190 GC13P033290 GC13P015203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RFC3:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory
proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a
protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa
subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists
of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been
described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

Gene Wiki entry for RFC3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RFC3 gene promoter:
         MyoD   Nkx2-5   NF-kappaB   Roaz   MZF-1   AREB6   COMP1   NF-kappaB2   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRFC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RFC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RFC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.2   Ensembl cytogenetic band:  13q13.2   HGNC cytogenetic band: 13q13.2

RFC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RFC3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P034392:  view genomic region     (about GC identifiers)

Start:
34,392,186 bp from pter      End:
34,540,695 bp from pter
Size:
148,510 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938 (See protein sequence)
Recommended Name: Replication factor C subunit 3  
Size: 356 amino acids; 40556 Da
Subunit: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17.
The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by
PCNA
Subcellular location: Nucleus (Probable)
Secondary accessions: C9JU95 O15252 Q5W0E8
Alternative splicing: 2 isoforms:  P40938-1   P40938-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RFC3: NX_P40938

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40938

  • RFC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002906.1  NP_853536.2  

    ENSEMBL proteins: 
     ENSP00000369411   ENSP00000401001  
    Reactome Protein details: P40938
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: RFC3
    OriGene Protein Over-expression Lysate (see all 3): RFC3
    OriGene Custom Protein Services for RFC3 
    GenScript Custom Purified and Recombinant Proteins Services for RFC3
    Novus Biologicals RFC3 Proteins
    Novus Biologicals RFC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RFC3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005663DNA replication factor C complex TAS7774928


    RFC3 for ontologies           About GeneDecksing



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    Abcam antibodies for RFC3 
    Uscn Antibodies for RFC3
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    Assay Products for RFC3: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for RFC3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RFC3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008921 DNA_pol3_clamp-load_cplx_C
     IPR013748 Rep_factorC_C_dom
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P40938

    ProtoNet protein and cluster: P40938

    UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938
    Similarity: Belongs to the activator 1 small subunits family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RFC3_HUMAN, P40938
    Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the
    accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

         Genatlas biochemistry entry for RFC3:
    replication factor C3,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP dependent,required
    to assemble PCNA and polymerase delta on the DNA template

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFC3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RFC3:
    hsa-miR-2052 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidRFC3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RFC3 (see all 7)
    OriGene shRNA RFP: RFC3
    OriGene siRNA: RFC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFC3

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RFC3 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RFC3 (NM_181558)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RFC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC3

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003677contributes to DNA binding IDA9488738
    GO:0003689DNA clamp loader activity TAS9488738
    GO:0005515protein binding IPI9488738
    GO:0005524ATP binding ----


    RFC3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RFC3:
     Increased cell death in HCT116  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lagging Strand Synthesis
    8/14 pathways (see all 14)
    Lagging Strand Synthesis1.00
    Gap-filling DNA repair synthesis and ligation in TC-NER0.64
    Telomere C-strand (Lagging Strand) Synthesis0.91
    Gap-filling DNA repair synthesis and ligation in GG-NER0.64
    Extension of Telomeres0.83
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.59
    Polymerase switching on the C-strand of the telomere0.70
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.59
    2Ubiquitinated Orc1 is degraded by the proteasome
    Synthesis of DNA0.51
    Cell Cycle Checkpoints0.42
    DNA Replication0.49
    S Phase0.40
    3Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)1.00
    Nucleotide Excision Repair Pathway0.49
    Nucleotide excision repair0.70
    4Nucleotide Excision Repair
    Nucleotide Excision Repair1.00
    DNA Repair0.46
    Transcription-coupled NER (TC-NER)0.90
    5Activation of ATR in response to replication stress
    Activation of ATR in response to replication stress1.00
    G2/M Checkpoints0.86

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RFC3
        Cell cycle Transition and termination of DNA replacation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RFC3
        Mismatch Repair in Eukaryotes
    Nucleotide Excision Repair Pathway

    1 GeneGo (Thomson Reuters) Pathway for RFC3
        Cell cycle Transition and termination of DNA replication

    1 BioSystems Pathway for RFC3 
        DNA Replication

    5/25        Reactome Pathways for RFC3 (see all 25)
        Extension of Telomeres
    Telomere Maintenance
    DNA Repair
    Activation of ATR in response to replication stress
    Leading Strand Synthesis


    3         Kegg Pathways  (Kegg details for RFC3):
        DNA replication
    Nucleotide excision repair
    Mismatch repair


    RFC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RFC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/840 Interacting proteins for RFC3 (P409381, 2, 3 ENSP000003694114) via UniProtKB, MINT, STRING, and/or I2D (see all 840)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000354720
    MESDC2Q146962, 3, ENSP000002617584MINT-8262958 I2D: score=2 STRING: ENSP00000261758
    BTAF1O149812, 3MINT-7945693 MINT-7947479 I2D: score=1 
    BUB1O436832, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--


    RFC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RFC3
    Search CenterWatch for drugs/clinical trials and news about RFC3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RFC3 gene (2 alternative transcripts): 
    NM_002915.3  NM_181558.2  

    Unigene Cluster for RFC3:

    Replication factor C (activator 1) 3, 38kDa
    Hs.115474  [show with all ESTs]
    Unigene Representative Sequence: AK128459
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380071(uc001uuz.3) ENST00000434425(uc010ted.1 uc001uva.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RFC3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RFC3:
    hsa-miR-2052 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidRFC3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: RFC3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RFC3
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RFC3 (NM_181558)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RFC3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RFC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RFC3

    Additional cDNA sequence: 

    AK128459.1 AK222572.1 AK296527.1 AK312544.1 BC000149.2 BT019668.1 L07541.1 

    11 DOTS entries:

    DT.456429  DT.100792521  DT.101972559  DT.100792524  DT.95276763  DT.120789338  DT.91767579  DT.100792519 
    DT.100792522  DT.120789343  DT.97791965 

    24/205 AceView cDNA sequences (see all 205):

    BQ436009 AV709344 AA460423 AW675027 AA743418 AW071578 AA455759 BU193565 
    BX477522 AA806873 BG284536 BQ022285 AA910425 BI859119 AW954129 BF062282 
    BU176632 CR598980 CB160967 AI354563 AA424909 AA506002 AA807174 BP338383 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RFC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RFC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RFC3

    SOURCE GeneReport for Unigene cluster: Hs.115474
        SABiosciences Custom PCR Arrays for RFC3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RFC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RFC3 gene from 9/38 species (see all 38)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RFC31 replication factor C (activator 1) 3, 38kDa 80.71(n)
    89.33(a)
      418907  NM_001006276.1  NP_001006276.1 
    lizard
    (Anolis carolinensis)
    Reptilia RFC36
    --
    90(a)
    1 ↔ 1
    3(183105489-183123856)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA791108.12   -- 77.48(n)    CA791108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC042327.12   -- 75.65(n)    BC042327.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD068373
    RfC381
    DNA clamp loader3
    Replication factor C 38kD subunit1
    60(a)3
    58.74(n)1
    60.17(a)1
      32D43
    345501  NM_135650.21  NP_609494.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rfc-31 , 3 Human activator 1 38 KD subunit like3
    Protein RFC-31
    53(a)3
    57.48(n)1
    54.55(a)1
      IV(13095940-13097109)3
    1782591  NM_070116.51  NP_502517.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RFC5(YBR087W)4
    RFC51
    Subunit of heteropentameric Replication factor C (RF-C), more4
    Rfc5p1
    50.39(n)1
    45.29(a)1
      2(423765-424829)4
    8523831, 4  NP_009644.31  NP_009644.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27751 replication factor C subunit 3/5 56.81(n)
    53.91(a)
      832836  NM_122656.4  NP_198126.1 
    rice
    (Oryza sativa)
    Liliopsida Os.280122 Oryza sativa (japonica cultivar-group) OsRFC5 mRNA more 73.68(n)    AK103751.1 


    ENSEMBL Gene Tree for RFC3 (if available)
    TreeFam Gene Tree for RFC3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RFC3 gene

    RFC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RFC3
    PGOHUM00000237580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2710 NCBI SNPs in RFC3 are shown (see all 2710    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790779161,2
    C,F,--34390283(+) CTACAT/CGGGAG 2 -- us2k15Minor allele frequency- C:0.25WA NA CSA EA 245
    rs31355211,2
    C,F,H,--34390636(+) AATTTC/GAAATA 2 -- us2k18Minor allele frequency- G:0.18NS EA CSA WA 771
    rs1511623421,2
    --34390952(+) ACTTAC/TTTCCA 2 -- us2k10--------
    rs31355221,2
    C,H,--34391200(+) gaaacA/Gtagtc 2 -- us2k15Minor allele frequency- G:0.00NS EA 588
    rs31355231,2
    C,F,H,--34391277(+) TTCTCG/AAGAAC 2 -- us2k119Minor allele frequency- A:0.15NS EA NA WA CSA 2402
    rs31355241,2
    H--34391296(+) AATCTT/AATACT 2 -- us2k15Minor allele frequency- A:0.00NS EA 586
    rs1852074751,2
    --34391382(+) ATTGAC/TTAATA 2 -- us2k10--------
    rs31355251,2
    C,F,H,--34391403(+) AGGCAC/ACTTGG 2 -- us2k1 tfbs310Minor allele frequency- A:0.05NS MN EA NA WA 1058
    rs797127271,2
    F,--34391429(+) TATATT/CTGGAA 2 -- us2k11Minor allele frequency- C:0.09WA 118
    rs743204591,2
    F,--34391482(+) TTAGGG/ATTCTT 2 -- us2k11Minor allele frequency- A:0.08WA 118

    HapMap Linkage Disequilibrium report for RFC3 (34392186 - 34540695 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RFC3
         1 CNV: 101699

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RFC3 for disorders           About GeneDecksing

    OMIM gene information: 600405    OMIM disorders: --

    4 diseases for RFC3:    About MalaCards
    graft versus host disease    colorectal cancer    immunodeficiency    malaria

    Human Genome Epidemiology (HuGE) Navigator: RFC3 (10 documents)

    Export disorders for RFC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RFC3 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with RFC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Purification and characterization of human DNA damage checkpoint Rad complexes. (PubMed id 11572977)1, 2 Lindsey-Boltz L.A.... Sancar A. (2001)
    3. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2 Rauen M.... Karnitz L.M. (2000)
    4. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PubMed id 7774928)1, 3 Okumura K....Ozawa K. (1995)
    5. Homology in accessory proteins of replicative polymerases -- E. coli to humans. (PubMed id 8441605)1, 2 O'Donnell M.... Hurwitz J. (1993)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Integrative genomics identified RFC3 as an amplified c andidate oncogene in esophageal adenocarcinoma. (PubMed id 22328562)1 Lockwood W.W....Beer D.G. (2012)
    9. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5983 HGNC: 9971 AceView: RFC3 Ensembl:ENSG00000133119 euGenes: HUgn5983
    ECgene: RFC3 Kegg: 5983 H-InvDB: RFC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RFC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RFC3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rfc3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RFC3 gene:
    Search GeneIP for patents involving RFC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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