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Aliases for RFC3 Gene

Aliases for RFC3 Gene

  • Replication Factor C (Activator 1) 3, 38kDa 2 3
  • A1 38 KDa Subunit 2 3 4
  • Replication Factor C 38 KDa Subunit 3 4
  • Activator 1 38 KDa Subunit 3 4
  • Activator 1 Subunit 3 3 4
  • RF-C 38 KDa Subunit 3 4
  • RFC38 3 4
  • Replication Factor C (Activator 1) 3 (38kD) 2
  • Replication Factor C Subunit 3 3
  • RFC, 38 KD Subunit 3
  • 38 KD Subunit 2
  • RFC 2

External Ids for RFC3 Gene

Summaries for RFC3 Gene

Entrez Gene Summary for RFC3 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for RFC3 Gene

RFC3 (Replication Factor C (Activator 1) 3, 38kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include nucleotide binding and DNA clamp loader activity.

UniProtKB/Swiss-Prot for RFC3 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

Gene Wiki entry for RFC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFC3 Gene

Genomics for RFC3 Gene

Genomic Location for RFC3 Gene

33,818,049 bp from pter
33,966,558 bp from pter
148,510 bases
Plus strand

Genomic View for RFC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RFC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFC3 Gene

Regulatory Elements for RFC3 Gene

Proteins for RFC3 Gene

  • Protein details for RFC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Replication factor C subunit 3
    Protein Accession:
    Secondary Accessions:
    • C9JU95
    • O15252
    • Q5W0E8

    Protein attributes for RFC3 Gene

    356 amino acids
    Molecular mass:
    40556 Da
    Quaternary structure:
    • Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.

    Alternative splice isoforms for RFC3 Gene


neXtProt entry for RFC3 Gene

Proteomics data for RFC3 Gene at MOPED

Post-translational modifications for RFC3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys20, Lys170, Lys202, and Lys225

Other Protein References for RFC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RFC3 Gene

Domains for RFC3 Gene

Gene Families for RFC3 Gene

  • AATP :ATPases / AAA-type

Protein Domains for RFC3 Gene


  • Belongs to the activator 1 small subunits family.:
    • P40938
genes like me logo Genes that share domains with RFC3: view

Function for RFC3 Gene

Molecular function for RFC3 Gene

GENATLAS Biochemistry: replication factor C3,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP dependent,required to assemble PCNA and polymerase delta on the DNA template
UniProtKB/Swiss-Prot Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1

Gene Ontology (GO) - Molecular Function for RFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IDA 9488738
GO:0003689 DNA clamp loader activity TAS 9488738
GO:0003887 DNA-directed DNA polymerase activity --
GO:0005515 protein binding IPI 9488738
GO:0005524 ATP binding --
genes like me logo Genes that share ontologies with RFC3: view

Phenotypes for RFC3 Gene

GenomeRNAi human phenotypes for RFC3:
genes like me logo Genes that share phenotypes with RFC3: view

miRNA for RFC3 Gene

miRTarBase miRNAs that target RFC3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RFC3 Gene

Localization for RFC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFC3 Gene

Subcellular locations from

Jensen Localization Image for RFC3 Gene COMPARTMENTS Subcellular localization image for RFC3 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005663 DNA replication factor C complex TAS 7774928
GO:0009360 DNA polymerase III complex --
genes like me logo Genes that share ontologies with RFC3: view

Pathways for RFC3 Gene

genes like me logo Genes that share pathways with RFC3: view

Pathways by source for RFC3 Gene

Gene Ontology (GO) - Biological Process for RFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
GO:0000731 DNA synthesis involved in DNA repair TAS 9488738
GO:0006200 obsolete ATP catabolic process --
genes like me logo Genes that share ontologies with RFC3: view

Transcripts for RFC3 Gene

Unigene Clusters for RFC3 Gene

Replication factor C (activator 1) 3, 38kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFC3 Gene

No ASD Table

Relevant External Links for RFC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFC3 Gene

mRNA expression in normal human tissues for RFC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFC3 Gene

SOURCE GeneReport for Unigene cluster for RFC3 Gene Hs.115474

genes like me logo Genes that share expressions with RFC3: view

Orthologs for RFC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RFC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFC3 36
  • 99.25 (n)
  • 99.16 (a)
RFC3 37
  • 99 (a)
(Bos Taurus)
Mammalia RFC3 36
  • 94.57 (n)
  • 98.6 (a)
RFC3 37
  • 99 (a)
(Canis familiaris)
Mammalia RFC3 36
  • 93.73 (n)
  • 99.72 (a)
RFC3 37
  • 100 (a)
(Mus musculus)
Mammalia Rfc3 36
  • 87.83 (n)
  • 97.19 (a)
Rfc3 16
Rfc3 37
  • 97 (a)
(Monodelphis domestica)
Mammalia RFC3 37
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RFC3 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Rfc3 36
  • 85.21 (n)
  • 96.91 (a)
(Gallus gallus)
Aves RFC3 36
  • 80.71 (n)
  • 89.33 (a)
RFC3 37
  • 90 (a)
(Anolis carolinensis)
Reptilia RFC3 37
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rfc3 36
  • 77.25 (n)
  • 89.33 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6760 36
(Danio rerio)
Actinopterygii rfc3 36
  • 73.41 (n)
  • 85.39 (a)
rfc3 37
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009047 36
  • 58.69 (n)
  • 64.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta RfC38 36
  • 58.74 (n)
  • 60.17 (a)
RfC38 37
  • 59 (a)
BcDNA:LD06837 38
  • 60 (a)
(Caenorhabditis elegans)
Secernentea rfc-3 36
  • 57.67 (n)
  • 54.84 (a)
rfc-3 37
  • 52 (a)
rfc-3 38
  • 53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL303C 36
  • 49.41 (n)
  • 45.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFC5 36
  • 50.39 (n)
  • 45.29 (a)
RFC5 37
  • 44 (a)
RFC5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12221g 36
  • 48.94 (n)
  • 46.24 (a)
(Glycine max)
eudicotyledons Gma.8866 36
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2775 36
  • 56.81 (n)
  • 53.91 (a)
(Hordeum vulgare)
Liliopsida Hv.2823 36
(Zea mays)
Liliopsida Zm.5155 36
(Oryza sativa)
Liliopsida Os.28012 36
Os03g0792600 36
  • 55.94 (n)
  • 53.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06769 36
  • 55.33 (n)
  • 54.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rfc5 36
  • 56.35 (n)
  • 50.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8470 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8435 37
  • 71 (a)
Species with no ortholog for RFC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RFC3 Gene

Gene Tree for RFC3 (if available)
Gene Tree for RFC3 (if available)

Paralogs for RFC3 Gene Pseudogenes for RFC3 Gene

genes like me logo Genes that share paralogs with RFC3: view

No data available for Paralogs for RFC3 Gene

Variants for RFC3 Gene

Sequence variations from dbSNP and Humsavar for RFC3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs167204 -- 33,822,491(-) TACTA(C/T)ACATT intron-variant
rs172461 -- 33,830,333(-) TCAAT(A/G)TTCCA intron-variant
rs212277 -- 33,823,386(-) TGATG(A/G)ACATT intron-variant
rs296895 -- 33,827,335(-) CAAGT(C/G)ATGTT intron-variant
rs296896 -- 33,824,775(-) TAAAT(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFC3 Gene

Variant ID Type Subtype PubMed ID
nsv995 CNV Insertion 18451855
nsv996 CNV Insertion 18451855
nsv899975 CNV Loss 21882294
esv2504202 CNV Deletion 19546169
nsv527943 CNV Loss 19592680
esv2747249 CNV Deletion 23290073
esv2747250 CNV Deletion 23290073
nsv528193 CNV Loss 19592680

Relevant External Links for RFC3 Gene

HapMap Linkage Disequilibrium report

Disorders for RFC3 Gene

Relevant External Links for RFC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RFC3: view

No data available for UniProtKB/Swiss-Prot for RFC3 Gene

Publications for RFC3 Gene

  1. Homology in accessory proteins of replicative polymerases -- E. coli to humans. (PMID: 8441605) O'Donnell M. … Hurwitz J. (Nucleic Acids Res. 1993) 3 4
  2. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PMID: 10884395) Rauen M. … Karnitz L.M. (J. Biol. Chem. 2000) 3 4
  3. Purification and characterization of human DNA damage checkpoint Rad complexes. (PMID: 11572977) Lindsey-Boltz L.A. … Sancar A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PMID: 7774928) Okumura K. … Ozawa K. (Genomics 1995) 2 3

Products for RFC3 Gene

Sources for RFC3 Gene

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