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Aliases for RFC3 Gene

Aliases for RFC3 Gene

  • Replication Factor C Subunit 3 2 3 5
  • A1 38 KDa Subunit 2 3 4
  • Replication Factor C (Activator 1) 3, 38kDa 2 3
  • Replication Factor C 38 KDa Subunit 3 4
  • Activator 1 38 KDa Subunit 3 4
  • Activator 1 Subunit 3 3 4
  • RF-C 38 KDa Subunit 3 4
  • RFC38 3 4
  • Replication Factor C (Activator 1) 3 (38kD) 2
  • RFC, 38 KD Subunit 3
  • 38 KD Subunit 2
  • RFC 2

External Ids for RFC3 Gene

Previous GeneCards Identifiers for RFC3 Gene

  • GC13P032378
  • GC13P028378
  • GC13P033328
  • GC13P032190
  • GC13P033290
  • GC13P034392
  • GC13P015203

Summaries for RFC3 Gene

Entrez Gene Summary for RFC3 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for RFC3 Gene

RFC3 (Replication Factor C Subunit 3) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include ATPase activity and DNA clamp loader activity.

UniProtKB/Swiss-Prot for RFC3 Gene

  • The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Gene Wiki entry for RFC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFC3 Gene

Genomics for RFC3 Gene

Regulatory Elements for RFC3 Gene

Enhancers for RFC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RFC3 on UCSC Golden Path with GeneCards custom track

Promoters for RFC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RFC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RFC3 Gene

33,818,049 bp from pter
33,973,946 bp from pter
155,898 bases
Plus strand

Genomic View for RFC3 Gene

Genes around RFC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFC3 Gene

Proteins for RFC3 Gene

  • Protein details for RFC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Replication factor C subunit 3
    Protein Accession:
    Secondary Accessions:
    • C9JU95
    • O15252
    • Q5W0E8

    Protein attributes for RFC3 Gene

    356 amino acids
    Molecular mass:
    40556 Da
    Quaternary structure:
    • Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.

    Alternative splice isoforms for RFC3 Gene


neXtProt entry for RFC3 Gene

Proteomics data for RFC3 Gene at MOPED

Post-translational modifications for RFC3 Gene

  • Ubiquitination at Lys 20, Lys 170, Lys 202, and Lys 225
  • Modification sites at PhosphoSitePlus

Other Protein References for RFC3 Gene

No data available for DME Specific Peptides for RFC3 Gene

Domains & Families for RFC3 Gene

Gene Families for RFC3 Gene

Protein Domains for RFC3 Gene

Suggested Antigen Peptide Sequences for RFC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the activator 1 small subunits family.
  • Belongs to the activator 1 small subunits family.
genes like me logo Genes that share domains with RFC3: view

Function for RFC3 Gene

Molecular function for RFC3 Gene

GENATLAS Biochemistry:
replication factor C3,component of complex A-1,DNA polymerase accessory protein "clamp loader",ATP dependent,required to assemble PCNA and polymerase delta on the DNA template
UniProtKB/Swiss-Prot Function:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
genes like me logo Genes that share phenotypes with RFC3: view

Animal Model Products

miRNA for RFC3 Gene

miRTarBase miRNAs that target RFC3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RFC3 Gene

Localization for RFC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFC3 Gene

Subcellular locations from

Jensen Localization Image for RFC3 Gene COMPARTMENTS Subcellular localization image for RFC3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RFC3 Gene

Pathways & Interactions for RFC3 Gene

SuperPathways for RFC3 Gene

Superpath Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 DNA Double-Strand Break Repair
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Homologous DNA Pairing and Strand Exchange
genes like me logo Genes that share pathways with RFC3: view

Gene Ontology (GO) - Biological Process for RFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance TAS --
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0000731 DNA synthesis involved in DNA repair TAS 9488738
GO:0006260 DNA replication IEA,TAS --
GO:0006271 DNA strand elongation involved in DNA replication TAS 7774928
genes like me logo Genes that share ontologies with RFC3: view

No data available for SIGNOR curated interactions for RFC3 Gene

Drugs & Compounds for RFC3 Gene

No Compound Related Data Available

Transcripts for RFC3 Gene

Unigene Clusters for RFC3 Gene

Replication factor C (activator 1) 3, 38kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RFC3 Gene

No ASD Table

Relevant External Links for RFC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFC3 Gene

mRNA expression in normal human tissues for RFC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RFC3 Gene

This gene is overexpressed in Breast (35.7), Bone (11.6), and Lung (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RFC3 Gene

SOURCE GeneReport for Unigene cluster for RFC3 Gene Hs.115474

genes like me logo Genes that share expression patterns with RFC3: view

Protein tissue co-expression partners for RFC3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RFC3 Gene

Orthologs for RFC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RFC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RFC3 35
  • 94.57 (n)
  • 98.6 (a)
RFC3 36
  • 99 (a)
(Canis familiaris)
Mammalia RFC3 35
  • 93.73 (n)
  • 99.72 (a)
RFC3 36
  • 100 (a)
(Mus musculus)
Mammalia Rfc3 35
  • 87.83 (n)
  • 97.19 (a)
Rfc3 16
Rfc3 36
  • 97 (a)
(Pan troglodytes)
Mammalia RFC3 35
  • 99.25 (n)
  • 99.16 (a)
RFC3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rfc3 35
  • 85.21 (n)
  • 96.91 (a)
(Monodelphis domestica)
Mammalia RFC3 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RFC3 36
  • 94 (a)
(Gallus gallus)
Aves RFC3 35
  • 80.71 (n)
  • 89.33 (a)
RFC3 36
  • 90 (a)
(Anolis carolinensis)
Reptilia RFC3 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rfc3 35
  • 77.25 (n)
  • 89.33 (a)
(Danio rerio)
Actinopterygii rfc3 35
  • 73.41 (n)
  • 85.39 (a)
rfc3 36
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6760 35
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD06837 37
  • 60 (a)
RfC38 35
  • 58.74 (n)
  • 60.17 (a)
RfC38 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009047 35
  • 58.69 (n)
  • 64.27 (a)
(Caenorhabditis elegans)
Secernentea rfc-3 37
  • 53 (a)
rfc-3 35
  • 57.67 (n)
  • 54.84 (a)
rfc-3 36
  • 52 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL303C 35
  • 49.41 (n)
  • 45.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12221g 35
  • 48.94 (n)
  • 46.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFC5 35
  • 50.39 (n)
  • 45.29 (a)
RFC5 36
  • 44 (a)
RFC5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2775 35
  • 56.81 (n)
  • 53.91 (a)
(Glycine max)
eudicotyledons Gma.8866 35
(Hordeum vulgare)
Liliopsida Hv.2823 35
(Oryza sativa)
Liliopsida Os.28012 35
Os03g0792600 35
  • 55.94 (n)
  • 53.91 (a)
(Zea mays)
Liliopsida Zm.5155 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8470 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06769 35
  • 55.33 (n)
  • 54.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rfc5 35
  • 56.35 (n)
  • 50.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8435 36
  • 71 (a)
Species with no ortholog for RFC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RFC3 Gene

Gene Tree for RFC3 (if available)
Gene Tree for RFC3 (if available)

Paralogs for RFC3 Gene Pseudogenes for RFC3 Gene

genes like me logo Genes that share paralogs with RFC3: view

No data available for Paralogs for RFC3 Gene

Variants for RFC3 Gene

Sequence variations from dbSNP and Humsavar for RFC3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs3135533 - 33,818,224(-) GACGG(C/G)TGGAC reference, missense
rs167204 -- 33,822,491(-) TACTA(C/T)ACATT intron-variant
rs172461 -- 33,830,333(-) TCAAT(A/G)TTCCA intron-variant
rs212277 -- 33,823,386(-) TGATG(A/G)ACATT intron-variant
rs296895 -- 33,827,335(-) CAAGT(C/G)ATGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RFC3 Gene

Variant ID Type Subtype PubMed ID
nsv995 CNV Insertion 18451855
nsv996 CNV Insertion 18451855
nsv899975 CNV Loss 21882294
esv2504202 CNV Deletion 19546169
nsv527943 CNV Loss 19592680
esv2747249 CNV Deletion 23290073
esv2747250 CNV Deletion 23290073
nsv528193 CNV Loss 19592680

Variation tolerance for RFC3 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RFC3 Gene

Disorders for RFC3 Gene

Relevant External Links for RFC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RFC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFC3 Gene

Publications for RFC3 Gene

  1. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PMID: 20226869) Thyagarajan B. … Arora M. (Biol. Blood Marrow Transplant. 2010) 3 48 67
  2. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. (PMID: 7774928) Okumura K. … Ozawa K. (Genomics 1995) 2 3
  3. Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA. (PMID: 25541153) Chae H.D. … Sakamoto K.M. (Leukemia 2015) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for RFC3 Gene

Sources for RFC3 Gene