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Aliases for REXO4 Gene

Aliases for REXO4 Gene

  • REX4 Homolog, 3'-5' Exonuclease 2
  • REX4 Homolog, 3-5 Exonuclease 2 3 5
  • Exonuclease XPMC2 3 4
  • XPMC2H 3 4
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog (Xenopus Laevis) 2
  • REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae) 2
  • Xenopus Prevents Mitotic Catastrophe 2 Homolog 3
  • Prevents Mitotic Catastrophe 2 Protein Homolog 4
  • Xenopus Prevents Mitotic Catatrophe 2 Homolog 2
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog 3
  • REX4, RNA Exonuclease 4 Homolog 3
  • RNA Exonuclease 4 3
  • EC 3.1.-.- 4
  • XPMC2 3
  • HPMC2 4
  • REX4 3
  • PMC2 4

External Ids for REXO4 Gene

Previous HGNC Symbols for REXO4 Gene

  • XPMC2H

Previous GeneCards Identifiers for REXO4 Gene

  • GC09M133301
  • GC09M135261
  • GC09M136271
  • GC09M105773

Summaries for REXO4 Gene

GeneCards Summary for REXO4 Gene

REXO4 (REX4 Homolog, 3'-5' Exonuclease) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ISG20L2.

Gene Wiki entry for REXO4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO4 Gene

Genomics for REXO4 Gene

Regulatory Elements for REXO4 Gene

Enhancers for REXO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F133112 1.7 FANTOM5 ENCODE 23.9 +289.2 289151 33.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 RALGDS SETX GTF3C4 TSC1 LOC100130548 REXO4 TTF1 SURF6 GBGT1 LINC00094
GH09F134168 1.6 FANTOM5 Ensembl ENCODE 21.3 -754.4 -754377 8.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 WDR5 REXO4 SURF6 LOC100130548 LINC00094 ENSG00000273249 ENSG00000273473 SARDH RXRA GC09P134218
GH09F134162 1.2 ENCODE 21.2 -746.3 -746314 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 WDR5 REXO4 SURF6 COL5A1-AS1 LOC100130548 ENSG00000273473 SURF4 ENSG00000273249 GC09M134165 RNU6ATAC
GH09F133485 1.2 Ensembl ENCODE 11.4 -68.2 -68216 1.2 WRNIP1 ARID4B ZNF48 ZNF2 RAD21 ZEB1 ZNF143 CREM DEK EGR2 CACFD1 ADAMTS13 REXO4 ENSG00000201451 ENSG00000230064 SURF6 SURF4 STKLD1 TMEM8C ADAMTSL2
GH09F133333 1.2 ENCODE 10.1 +82.9 82889 4.2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SURF6 SURF1 WDR5 GTF3C4 LOC100130548 TSC1 SURF4 REXO4 RXRA TTF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around REXO4 on UCSC Golden Path with GeneCards custom track

Promoters for REXO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000251902 272 2201 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for REXO4 Gene

Chromosome:
9
Start:
133,406,058 bp from pter
End:
133,418,172 bp from pter
Size:
12,115 bases
Orientation:
Minus strand

Genomic View for REXO4 Gene

Genes around REXO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO4 Gene

Proteins for REXO4 Gene

  • Protein details for REXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR2-REXO4_HUMAN
    Recommended name:
    RNA exonuclease 4
    Protein Accession:
    Q9GZR2
    Secondary Accessions:
    • B2RAT2
    • Q5T8S4
    • Q5T8S5
    • Q5T8S6
    • Q9GZW3

    Protein attributes for REXO4 Gene

    Size:
    422 amino acids
    Molecular mass:
    46672 Da
    Quaternary structure:
    • Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.
    SequenceCaution:
    • Sequence=CAI12845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12847.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for REXO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REXO4 Gene

Post-translational modifications for REXO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REXO4 Gene

No data available for DME Specific Peptides for REXO4 Gene

Domains & Families for REXO4 Gene

Gene Families for REXO4 Gene

Protein Domains for REXO4 Gene

Suggested Antigen Peptide Sequences for REXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZR2

UniProtKB/Swiss-Prot:

REXO4_HUMAN :
  • Contains 1 exonuclease domain.
  • Belongs to the REXO4 family.
Domain:
  • Contains 1 exonuclease domain.
Family:
  • Belongs to the REXO4 family.
genes like me logo Genes that share domains with REXO4: view

Function for REXO4 Gene

Enzyme Numbers (IUBMB) for REXO4 Gene

Gene Ontology (GO) - Molecular Function for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 10908561
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with REXO4: view
genes like me logo Genes that share phenotypes with REXO4: view

Animal Model Products

miRNA for REXO4 Gene

miRTarBase miRNAs that target REXO4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO4 Gene

Localization for REXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REXO4 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IDA 10908561
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with REXO4: view

Pathways & Interactions for REXO4 Gene

SuperPathways for REXO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 10908561
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO4: view

No data available for Pathways by source and SIGNOR curated interactions for REXO4 Gene

Transcripts for REXO4 Gene

Unigene Clusters for REXO4 Gene

REX4, RNA exonuclease 4 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2:
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - -
SP8: - -

Relevant External Links for REXO4 Gene

GeneLoc Exon Structure for
REXO4
ECgene alternative splicing isoforms for
REXO4

Expression for REXO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for REXO4 Gene

Protein differential expression in normal tissues from HIPED for REXO4 Gene

This gene is overexpressed in Lung (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REXO4 Gene



NURSA nuclear receptor signaling pathways regulating expression of REXO4 Gene:

REXO4

SOURCE GeneReport for Unigene cluster for REXO4 Gene:

Hs.438409
genes like me logo Genes that share expression patterns with REXO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for REXO4 Gene

Orthologs for REXO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REXO4 34 35
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia REXO4 34 35
  • 80.2 (n)
rat
(Rattus norvegicus)
Mammalia Rexo4 34
  • 76.86 (n)
mouse
(Mus musculus)
Mammalia Rexo4 34 16 35
  • 76.23 (n)
cow
(Bos Taurus)
Mammalia REXO4 34 35
  • 74.26 (n)
oppossum
(Monodelphis domestica)
Mammalia REXO4 35
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REXO4 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves REXO4 34 35
  • 63.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo4 34
  • 60.16 (n)
Str.8400 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52582 34
zebrafish
(Danio rerio)
Actinopterygii si:ch73-209e20.4 34
  • 57.53 (n)
REXO4 35
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13999 34
fruit fly
(Drosophila melanogaster)
Insecta CG6833 35
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.12 35
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 35 37
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4479 34
Species where no ortholog for REXO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO4 Gene

ENSEMBL:
Gene Tree for REXO4 (if available)
TreeFam:
Gene Tree for REXO4 (if available)

Paralogs for REXO4 Gene

Paralogs for REXO4 Gene

(1) SIMAP similar genes for REXO4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for REXO4 Gene

genes like me logo Genes that share paralogs with REXO4: view

Variants for REXO4 Gene

Sequence variations from dbSNP and Humsavar for REXO4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1045447 -- 133,406,296(-) AGGTC(A/G)GCAGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111200225 -- 133,408,934(+) CATCT(G/T)TGTGT intron-variant
rs111392717 -- 133,407,655(+) ACTCC(A/G)CTCTA intron-variant
rs111587591 -- 133,418,770(+) CATAA(C/T)CGGTT intron-variant, upstream-variant-2KB
rs112617212 -- 133,419,759(+) TTTGA(A/G)ACGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for REXO4 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259
nsv433408 CNV gain 18776910

Variation tolerance for REXO4 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REXO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REXO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO4 Gene

Disorders for REXO4 Gene

Relevant External Links for REXO4

Genetic Association Database (GAD)
REXO4
Human Genome Epidemiology (HuGE) Navigator
REXO4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REXO4

No disorders were found for REXO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO4 Gene

Publications for REXO4 Gene

  1. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. (PMID: 9325058) Kwiatkowska J. … Kwiatkowski D.J. (Genomics 1997) 2 3 4 22 64
  2. The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites. (PMID: 21602889) Krishnamurthy N. … Montano M.M. (Oncogene 2011) 2 3 64
  3. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PMID: 20098615) Wooten E.C. … Huggins G.S. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for REXO4 Gene

Sources for REXO4 Gene

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