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Aliases for REXO4 Gene

Aliases for REXO4 Gene

  • REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae) 2 3
  • XPMC2H 3 4 6
  • Exonuclease XPMC2 3 4
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog (Xenopus Laevis) 2
  • Xenopus Prevents Mitotic Catastrophe 2 Homolog 3
  • Prevents Mitotic Catastrophe 2 Protein Homolog 4
  • Xenopus Prevents Mitotic Catatrophe 2 Homolog 2
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog 3
  • RNA Exonuclease 4 3
  • EC 3.1.-.- 4
  • XPMC2 3
  • HPMC2 4
  • REX4 3
  • PMC2 4

External Ids for REXO4 Gene

Previous HGNC Symbols for REXO4 Gene

  • XPMC2H

Previous GeneCards Identifiers for REXO4 Gene

  • GC09M133301
  • GC09M135261
  • GC09M136271
  • GC09M105773

Summaries for REXO4 Gene

GeneCards Summary for REXO4 Gene

REXO4 (REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and exonuclease activity. An important paralog of this gene is ISG20.

Gene Wiki entry for REXO4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO4 Gene

Genomics for REXO4 Gene

Regulatory Elements for REXO4 Gene

Genomic Location for REXO4 Gene

Start:
133,406,058 bp from pter
End:
133,418,172 bp from pter
Size:
12,115 bases
Orientation:
Minus strand

Genomic View for REXO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO4 Gene

Proteins for REXO4 Gene

  • Protein details for REXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR2-REXO4_HUMAN
    Recommended name:
    RNA exonuclease 4
    Protein Accession:
    Q9GZR2
    Secondary Accessions:
    • B2RAT2
    • Q5T8S4
    • Q5T8S5
    • Q5T8S6
    • Q9GZW3

    Protein attributes for REXO4 Gene

    Size:
    422 amino acids
    Molecular mass:
    46672 Da
    Quaternary structure:
    • Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment
    SequenceCaution:
    • Sequence=CAI12845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12847.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for REXO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REXO4 Gene

Proteomics data for REXO4 Gene at MOPED

Post-translational modifications for REXO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REXO4 Gene

No data available for DME Specific Peptides for REXO4 Gene

Domains for REXO4 Gene

Protein Domains for REXO4 Gene

Suggested Antigen Peptide Sequences for REXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZR2

UniProtKB/Swiss-Prot:

REXO4_HUMAN :
  • Q9GZR2
Domain:
  • Contains 1 exonuclease domain.
Family:
  • Belongs to the REXO4 family.
genes like me logo Genes that share domains with REXO4: view

No data available for Gene Families for REXO4 Gene

Function for REXO4 Gene

Enzyme Numbers (IUBMB) for REXO4 Gene

Gene Ontology (GO) - Molecular Function for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10908561
GO:0004527 exonuclease activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with REXO4: view

Phenotypes for REXO4 Gene

GenomeRNAi human phenotypes for REXO4:
genes like me logo Genes that share phenotypes with REXO4: view

miRNA for REXO4 Gene

miRTarBase miRNAs that target REXO4

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for REXO4 Gene

Localization for REXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REXO4 Gene COMPARTMENTS Subcellular localization image for REXO4 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10908561
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with REXO4: view

Pathways for REXO4 Gene

SuperPathways for REXO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 10908561
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO4: view

No data available for Pathways by source for REXO4 Gene

Transcripts for REXO4 Gene

Unigene Clusters for REXO4 Gene

REX4, RNA exonuclease 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REXO4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2:
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - -
SP8: - -

Relevant External Links for REXO4 Gene

GeneLoc Exon Structure for
REXO4
ECgene alternative splicing isoforms for
REXO4

Expression for REXO4 Gene

mRNA expression in normal human tissues for REXO4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for REXO4 Gene

SOURCE GeneReport for Unigene cluster for REXO4 Gene Hs.438409

genes like me logo Genes that share expressions with REXO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for REXO4 Gene

Orthologs for REXO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REXO4 35
  • 98.89 (n)
  • 98.58 (a)
REXO4 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia REXO4 35
  • 74.26 (n)
  • 67.08 (a)
REXO4 36
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REXO4 35
  • 80.2 (n)
  • 75.88 (a)
REXO4 36
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rexo4 35
  • 76.23 (n)
  • 73.1 (a)
Rexo4 16
Rexo4 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia REXO4 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REXO4 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rexo4 35
  • 76.86 (n)
  • 71.18 (a)
chicken
(Gallus gallus)
Aves REXO4 35
  • 63.44 (n)
  • 62.96 (a)
REXO4 36
  • 40 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52582 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo4 35
  • 60.16 (n)
  • 58.58 (a)
Str.8400 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13999 35
zebrafish
(Danio rerio)
Actinopterygii REXO4 36
  • 36 (a)
OneToOne
si:ch73-209e20.4 35
  • 57.53 (n)
  • 52.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6833 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.12 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 36
  • 28 (a)
OneToMany
REX4 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4479 35
Species with no ortholog for REXO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO4 Gene

ENSEMBL:
Gene Tree for REXO4 (if available)
TreeFam:
Gene Tree for REXO4 (if available)

Paralogs for REXO4 Gene

Paralogs for REXO4 Gene

Selected SIMAP similar genes for REXO4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for REXO4 Gene

genes like me logo Genes that share paralogs with REXO4: view

Variants for REXO4 Gene

Sequence variations from dbSNP and Humsavar for REXO4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2148993 -- 133,407,493(-) GCCCC(A/G)CTGAG intron-variant
rs2182812 -- 133,407,494(-) GGCCC(C/T)ACTGA intron-variant
rs2285481 -- 133,406,620(+) TGGGC(A/G)GTGAC utr-variant-3-prime, nc-transcript-variant
rs2285482 -- 133,406,668(+) CACCT(G/T)GCCCA utr-variant-3-prime, nc-transcript-variant
rs2285483 -- 133,406,714(+) CCCAT(A/G)GCCGT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for REXO4 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894080 CNV Loss 21882294
nsv894081 CNV Loss 21882294
nsv433408 CNV Gain 18776910
nsv894082 CNV Loss 21882294
dgv8328n71 CNV Loss 21882294
nsv894086 CNV Gain 21882294

Relevant External Links for REXO4 Gene

HapMap Linkage Disequilibrium report
REXO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO4 Gene

Disorders for REXO4 Gene

Relevant External Links for REXO4

Genetic Association Database (GAD)
REXO4
Human Genome Epidemiology (HuGE) Navigator
REXO4
genes like me logo Genes that share disorders with REXO4: view

No data available for UniProtKB/Swiss-Prot for REXO4 Gene

Publications for REXO4 Gene

  1. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. (PMID: 9325058) Kwiatkowska J. … Kwiatkowski D.J. (Genomics 1997) 2 3 4 23
  2. Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity. (PMID: 10908561) Montano M.M. … Bianco N.R. (J. Biol. Chem. 2000) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  5. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PMID: 20098615) Wooten E.C. … Huggins G.S. (PLoS ONE 2010) 3 48

Products for REXO4 Gene

Sources for REXO4 Gene

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