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Aliases for REXO4 Gene

Aliases for REXO4 Gene

  • REX4 Homolog, 3'-5' Exonuclease 2
  • REX4 Homolog, 3-5 Exonuclease 2 3 5
  • Exonuclease XPMC2 3 4
  • XPMC2H 3 4
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog (Xenopus Laevis) 2
  • REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae) 2
  • Xenopus Prevents Mitotic Catastrophe 2 Homolog 3
  • Prevents Mitotic Catastrophe 2 Protein Homolog 4
  • Xenopus Prevents Mitotic Catatrophe 2 Homolog 2
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog 3
  • REX4, RNA Exonuclease 4 Homolog 3
  • EC 3.1.-.- 4
  • XPMC2 3
  • HPMC2 4
  • REX4 3
  • PMC2 4

External Ids for REXO4 Gene

Previous HGNC Symbols for REXO4 Gene

  • XPMC2H

Previous GeneCards Identifiers for REXO4 Gene

  • GC09M133301
  • GC09M135261
  • GC09M136271
  • GC09M105773

Summaries for REXO4 Gene

GeneCards Summary for REXO4 Gene

REXO4 (REX4 Homolog, 3'-5' Exonuclease) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ISG20.

Gene Wiki entry for REXO4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO4 Gene

Genomics for REXO4 Gene

Regulatory Elements for REXO4 Gene

Enhancers for REXO4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around REXO4 on UCSC Golden Path with GeneCards custom track

Promoters for REXO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around REXO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for REXO4 Gene

133,406,058 bp from pter
133,418,172 bp from pter
12,115 bases
Minus strand

Genomic View for REXO4 Gene

Genes around REXO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO4 Gene

Proteins for REXO4 Gene

  • Protein details for REXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA exonuclease 4
    Protein Accession:
    Secondary Accessions:
    • B2RAT2
    • Q5T8S4
    • Q5T8S5
    • Q5T8S6
    • Q9GZW3

    Protein attributes for REXO4 Gene

    422 amino acids
    Molecular mass:
    46672 Da
    Quaternary structure:
    • Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.
    • Sequence=CAI12845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12847.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for REXO4 Gene


neXtProt entry for REXO4 Gene

Proteomics data for REXO4 Gene at MOPED

Post-translational modifications for REXO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REXO4 Gene

No data available for DME Specific Peptides for REXO4 Gene

Domains & Families for REXO4 Gene

Gene Families for REXO4 Gene

Protein Domains for REXO4 Gene

Suggested Antigen Peptide Sequences for REXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 exonuclease domain.
  • Belongs to the REXO4 family.
  • Contains 1 exonuclease domain.
  • Belongs to the REXO4 family.
genes like me logo Genes that share domains with REXO4: view

Function for REXO4 Gene

Enzyme Numbers (IUBMB) for REXO4 Gene

Gene Ontology (GO) - Molecular Function for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004527 exonuclease activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with REXO4: view
genes like me logo Genes that share phenotypes with REXO4: view

Animal Model Products

miRNA for REXO4 Gene

miRTarBase miRNAs that target REXO4

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO4 Gene

Localization for REXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO4 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for REXO4 Gene COMPARTMENTS Subcellular localization image for REXO4 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for REXO4 Gene

Pathways & Interactions for REXO4 Gene

SuperPathways for REXO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REXO4 Gene


No data available for Pathways by source and SIGNOR curated interactions for REXO4 Gene

Drugs & Compounds for REXO4 Gene

No Compound Related Data Available

Transcripts for REXO4 Gene

Unigene Clusters for REXO4 Gene

REX4, RNA exonuclease 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REXO4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - -
SP8: - -

Relevant External Links for REXO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REXO4 Gene

mRNA expression in normal human tissues for REXO4 Gene

Protein differential expression in normal tissues from HIPED for REXO4 Gene

This gene is overexpressed in Lung (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for REXO4 Gene

SOURCE GeneReport for Unigene cluster for REXO4 Gene Hs.438409

genes like me logo Genes that share expression patterns with REXO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for REXO4 Gene

Orthologs for REXO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia REXO4 35
  • 74.26 (n)
  • 67.08 (a)
REXO4 36
  • 47 (a)
(Canis familiaris)
Mammalia REXO4 35
  • 80.2 (n)
  • 75.88 (a)
REXO4 36
  • 45 (a)
(Mus musculus)
Mammalia Rexo4 35
  • 76.23 (n)
  • 73.1 (a)
Rexo4 16
Rexo4 36
  • 50 (a)
(Pan troglodytes)
Mammalia REXO4 35
  • 98.89 (n)
  • 98.58 (a)
REXO4 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Rexo4 35
  • 76.86 (n)
  • 71.18 (a)
(Monodelphis domestica)
Mammalia REXO4 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia REXO4 36
  • 43 (a)
(Gallus gallus)
Aves REXO4 35
  • 63.44 (n)
  • 62.96 (a)
REXO4 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo4 35
  • 60.16 (n)
  • 58.58 (a)
Str.8400 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52582 35
(Danio rerio)
Actinopterygii si:ch73-209e20.4 35
  • 57.53 (n)
  • 52.48 (a)
REXO4 36
  • 36 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13999 35
fruit fly
(Drosophila melanogaster)
Insecta CG6833 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea Y17G7B.12 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 36
  • 28 (a)
REX4 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4479 35
Species with no ortholog for REXO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO4 Gene

Gene Tree for REXO4 (if available)
Gene Tree for REXO4 (if available)

Paralogs for REXO4 Gene

Paralogs for REXO4 Gene

(1) SIMAP similar genes for REXO4 Gene using alignment to 1 proteins: Pseudogenes for REXO4 Gene

genes like me logo Genes that share paralogs with REXO4: view

Variants for REXO4 Gene

Sequence variations from dbSNP and Humsavar for REXO4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_023067 -
VAR_023068 -
rs7851389 -- 133,409,578(+) ttgtt(G/T)tttga intron-variant
rs7860836 -- 133,408,989(+) GTGAC(A/G)GAGTC intron-variant
rs113183502 -- 133,412,111(+) AGTGC(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REXO4 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894080 CNV Loss 21882294
nsv894081 CNV Loss 21882294
nsv433408 CNV Gain 18776910
nsv894082 CNV Loss 21882294
dgv8328n71 CNV Loss 21882294
nsv894086 CNV Gain 21882294

Variation tolerance for REXO4 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for REXO4 Gene

Disorders for REXO4 Gene

Relevant External Links for REXO4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for REXO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO4 Gene

Publications for REXO4 Gene

  1. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. (PMID: 9325058) Kwiatkowska J. … Kwiatkowski D.J. (Genomics 1997) 2 3 4 23 67
  2. The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites. (PMID: 21602889) Krishnamurthy N. … Montano M.M. (Oncogene 2011) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for REXO4 Gene

Sources for REXO4 Gene