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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REXO4 Gene

protein-coding   GIFtS: 53
GCID: GC09M136271

REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae)

(Previous names: Xenopus prevents mitotic catatrophe 2 homolog, XPMC2 prevents...)
(Previous symbol: XPMC2H)
  Search for REXO4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae)1 2     RNA Exonuclease 42
XPMC2H1 2 3 5     Xenopus Prevents Mitotic Catastrophe 2 Homolog2
Exonuclease XPMC22 3     XPMC2 Prevents Mitotic Catastrophe 2 Homolog2
Xenopus Prevents Mitotic Catatrophe 2 Homolog1     EC 3.1.-.-3
XPMC2 Prevents Mitotic Catastrophe 2 Homolog (Xenopus Laevis)1     PMC23
REX42     hPMC23
XPMC22     Prevents Mitotic Catastrophe 2 Protein Homolog3

External Ids:    HGNC: 128201   Entrez Gene: 571092   Ensembl: ENSG000001483007   OMIM: 6029305   UniProtKB: Q9GZR23   

Export aliases for REXO4 gene to outside databases

Previous GC identifers: GC09M133301 GC09M135261 GC09M105773


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for REXO4 Gene: 
REXO4 (REX4, RNA exonuclease 4 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include exonuclease activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISG20.

Gene Wiki entry for REXO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REXO4 gene promoter:
         NF-1   AML1a   AP-1   XBP-1   Tal-1beta   E47   CREB   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREXO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for REXO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REXO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.2   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34

REXO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REXO4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136271:  view genomic region     (about GC identifiers)

Start:
136,271,186 bp from pter      End:
136,283,164 bp from pter
Size:
11,979 bases      Orientation:
minus strand

1 alternative location:
Chr9-,NW_003315925 232,156-244,138     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REXO4_HUMAN, Q9GZR2 (See protein sequence)
Recommended Name: RNA exonuclease 4  
Size: 422 amino acids; 46672 Da
Subunit: Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=CAI12845.1; Type=Erroneous gene model prediction; Sequence=CAI12847.1; Type=Erroneous
gene model prediction; Sequence=CAI12848.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RAT2 Q5T8S4 Q5T8S5 Q5T8S6 Q9GZW3
Alternative splicing: 2 isoforms:  Q9GZR2-1   Q9GZR2-2   (Gene prediction based on EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for REXO4: NX_Q9GZR2

Explore proteomics data for REXO4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZR2

  • REXO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REXO4 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001266278.1  NP_001266279.1  NP_001266280.1  NP_065118.2  

    ENSEMBL proteins: 
     ENSP00000403272   ENSP00000361010   ENSP00000394229   ENSP00000391534   ENSP00000361003  

    Human Recombinant Protein Products for REXO4: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REXO4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10908561
    GO:0005730nucleolus IDA--

    REXO4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for REXO4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZR2

    ProtoNet protein and cluster: Q9GZR2

    1 Blocks protein domain: IPB006055 Exonuclease

    UniProtKB/Swiss-Prot: REXO4_HUMAN, Q9GZR2
    Similarity: Belongs to the REXO4 family
    Similarity: Contains 1 exonuclease domain


    REXO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10908561
    GO:0004527exonuclease activity IEA--
         
    REXO4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for REXO4:
     High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for REXO4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REXO4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REXO4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REXO4 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidREXO4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REXO4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for REXO4 (Q9GZR23 ENSP000003610104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=2 STRING: ENSP00000343925
    ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent NAS10908561

    REXO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REXO4

    Search CenterWatch for drugs/clinical trials and news about REXO4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REXO4 gene (4 alternative transcripts): 
    NM_001279349.1  NM_001279350.1  NM_001279351.1  NM_020385.3  

    Unigene Cluster for REXO4:

    REX4, RNA exonuclease 4 homolog (S. cerevisiae)
    Hs.438409  [show with all ESTs]
    Unigene Representative Sequence: NM_020385
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453165 ENST00000371942(uc011mde.2 uc004cdm.3 uc011mdf.2 uc004cdn.3)
    ENST00000454825 ENST00000494045 ENST00000478037 ENST00000445916 ENST00000371935

    miRNA
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for REXO4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REXO4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REXO4

    Additional mRNA sequence: 

    AF273304.1 AF295774.1 AK000247.1 AK025493.1 AK295982.1 AK304547.1 AK310164.1 AK314333.1 
    AK315904.1 AL136894.1 BC009274.2 BC071691.1 

    17 DOTS entries:

    DT.111797  DT.100768830  DT.99964509  DT.100776447  DT.91745024  DT.86843527  DT.121151948  DT.99950045 
    DT.121151705  DT.121152196  DT.111798  DT.121151728  DT.100748566  DT.121152086  DT.100723270  DT.100782251 
    DT.91745023 

    24/172 AceView cDNA sequences (see all 172):

    BQ882500 AI365980 BQ439687 BQ006597 AL136894 CA443749 BQ049189 BC071691 
    BQ946299 CR591994 AK000247 BM983220 CR597347 CF141366 BM789004 N55313 
    BC009274 BQ227684 BI334765 BU189945 AK025493 CF131202 BQ890065 CA424354 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for REXO4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                          -     -     -                                   -                                                   
    SP2:                                                                                                                              
    SP3:                          -     -     -     -                       -     -     -     -                                       
    SP4:                          -     -     -     -                             -                                                   
    SP5:                                                                          -                                                   


    ECgene alternative splicing isoforms for REXO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REXO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACCTTGG
    REXO4 Expression
    About this image


    See REXO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REXO4

    SOURCE GeneReport for Unigene cluster: Hs.438409
        SABiosciences Custom PCR Arrays for REXO4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for REXO4 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rexo41 , 5 REX4, RNA exonuclease 4 homolog (S. cerevisiae)1, 5 76.63(n)1
    73.12(a)1
      2 (19.13 cM)5
    2276561  NM_207234.21  NP_997117.21 
     269535635 
    chicken
    (Gallus gallus)
    Aves REXO41 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 60.91(n)
    58.25(a)
      417153  XM_415436.2  XP_415436.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525822 similar to Xenopus prevents mitotic catastrophe 2 homolog 74.59(n)    BC043958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003331271 RNA exonuclease 4-like 55.76(n)
    50.4(a)
      100333127  XM_002665867.1  XP_002665913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68331 CG6833 48.8(n)
    41.2(a)
      39559  NM_001202176.1  NP_001189105.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y17G7B.121 Protein Y17G7B.12 54.53(n)
    50.29(a)
      174842  NM_064159.3  NP_496560.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX4(YOL080C)4
    REX41
    Putative RNA exonuclease possibly involved in pre-rRNA more4
    Rex4p1
    51.42(n)1
    48.78(a)1
      15(181427-180558)4
    8540751, 4  NP_014561.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G150801 exonuclease-like protein 57.83(n)
    53.01(a)
      820738  NM_112370.3  NP_566499.1 
    rice
    (Oryza sativa)
    Liliopsida AK105467.12   -- 70.65(n)    AK105467.1 


    ENSEMBL Gene Tree for REXO4 (if available)
    TreeFam Gene Tree for REXO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REXO4 gene
    ISG202  AEN2  ISG20L22  
    1 SIMAP similar gene for REXO4 using alignment to 1 protein entry:     REXO4_HUMAN:
    ISG20L2

    REXO4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for REXO4
    PGOHUM00000246718


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 SNPs in REXO4 are shown (see all 163)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0230674
    ----see VAR_0230672 R K mis40--------
    VAR_0230684
    ----see VAR_0230682 T A mis40--------
    rs413074261,2
    C,F--136271734(+) TCACCG/AAAGAT 1 -- ut312Minor allele frequency- A:0.06WA NA 238
    rs22854811,2
    C,F,A,H--136271744(+) TGGGCA/GGTGAC 1 -- ut31 ese313Minor allele frequency- G:0.05EA NA NS WA 2084
    rs22854821,2
    C,F,A,H--136271792(+) CACCTG/TGCCCA 1 -- ut31 ese310Minor allele frequency- T:0.06EA NS NA CSA WA 1660
    rs736604851,2
    C--136271802(+) AGGGGG/TTCAGC 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs783135541,2
    C,F--136271812(+) CAGTCG/AGTAAA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs22854831,2
    C,F--136271838(+) CCCATG/AGCCGT 1 -- ut31 ese35Minor allele frequency- A:0.15NA WA 244
    rs22854841,2
    C,F,A,H--136271841(+) ATGGCA/C/GGTCCC 2 -- ut31 ese39EA NS NA CSA WA 543
    rs1893063111,2
    --136271886(+) CATGGA/GCAGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for REXO4 (136271186 - 136283164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for REXO4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv894081CNV Loss21882294
    dgv8328n71CNV Loss21882294
    dgv8325n71CNV Loss21882294
    nsv894082CNV Loss21882294
    nsv894080CNV Loss21882294
    nsv433408CNV Gain18776910
    nsv894086CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    REXO4 for disorders           About MalaCards
    OMIM gene information: 602930    OMIM disorders: --


    REXO4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): REXO4
    Human Genome Epidemiology (HuGE) Navigator: REXO4 (1 document)

    Export disorders for REXO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REXO4 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with REXO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. (PubMed id 9325058)1, 2, 3, 9 Kwiatkowska J.... Kwiatkowski D.J. (1997)
    2. Application of gene network analysis techniques ident ifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve . (PubMed id 20098615)1, 4 Wooten E.C....Huggins G.S. (2010)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity. (PubMed id 10908561)1, 2 Montano M.M.... Bianco N.R. (2000)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57109 HGNC: 12820 AceView: XPMC2H Ensembl:ENSG00000148300 euGenes: HUgn57109
    ECgene: REXO4 H-InvDB: REXO4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REXO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REXO4 gene:
    Search GeneIP for patents involving REXO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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