Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



REXO4 Gene

protein-coding   GIFtS: 54
GCID: GC09M136271

REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae)

(Previous names: Xenopus prevents mitotic catatrophe 2 homolog, XPMC2 prevents...)
(Previous symbol: XPMC2H)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae)1 2     RNA Exonuclease 42
XPMC2H1 2 3 5     Xenopus Prevents Mitotic Catastrophe 2 Homolog2
Exonuclease XPMC22 3     XPMC2 Prevents Mitotic Catastrophe 2 Homolog2
Xenopus Prevents Mitotic Catatrophe 2 Homolog1     EC 3.1.-.-3
XPMC2 Prevents Mitotic Catastrophe 2 Homolog (Xenopus Laevis)1     PMC23
REX42     hPMC23
XPMC22     Prevents Mitotic Catastrophe 2 Protein Homolog3

External Ids:    HGNC: 128201   Entrez Gene: 571092   Ensembl: ENSG000001483007   OMIM: 6029305   UniProtKB: Q9GZR23   

Export aliases for REXO4 gene to outside databases

Previous GC identifers: GC09M133301 GC09M135261 GC09M105773


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for REXO4 Gene:
REXO4 (REX4, RNA exonuclease 4 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include exonuclease activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISG20.

Gene Wiki entry for REXO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the REXO4 gene promoter:
         NF-1   AML1a   AP-1   XBP-1   Tal-1beta   E47   CREB   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREXO4 promoter sequence
   Search Chromatin IP Primers for REXO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REXO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.2   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34

REXO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REXO4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136271:  view genomic region     (about GC identifiers)

Start:
136,271,186 bp from pter      End:
136,283,164 bp from pter
Size:
11,979 bases      Orientation:
minus strand

1 alternative location:
Chr9-,NW_003315925 232,156-244,138     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: REXO4_HUMAN, Q9GZR2 (See protein sequence)
Recommended Name: RNA exonuclease 4  
Size: 422 amino acids; 46672 Da
Subunit: Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment
Sequence caution: Sequence=CAI12845.1; Type=Erroneous gene model prediction; Sequence=CAI12847.1; Type=Erroneous
gene model prediction; Sequence=CAI12848.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RAT2 Q5T8S4 Q5T8S5 Q5T8S6 Q9GZW3
Alternative splicing: 2 isoforms:  Q9GZR2-1   Q9GZR2-2   (Gene prediction based on EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for REXO4: NX_Q9GZR2

Explore proteomics data for REXO4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REXO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001266278.1  NP_001266279.1  NP_001266280.1  NP_065118.2  

    ENSEMBL proteins: 
     ENSP00000361010   ENSP00000394229   ENSP00000391534   ENSP00000361003  

    REXO4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for REXO4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for REXO4
    GenScript Custom Purified and Recombinant Proteins Services for REXO4
    Novus Biologicals REXO4 Protein
    Novus Biologicals REXO4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REXO4

     
    Search eBioscience for Proteins for REXO4 

     
    antibodies-online proteins for REXO4 (7 products) 

     
    Search antibodies-online for peptides for REXO4

    REXO4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for REXO4
    Novus Biologicals REXO4 Antibodies
    Abcam antibodies for REXO4
    Cloud-Clone Corp. Antibodies for REXO4
    ThermoFisher Antibodies for REXO4
    antibodies-online antibodies for REXO4 (13 products) 

    REXO4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for REXO4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REXO4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for REXO4
    Cloud-Clone Corp. CLIAs for REXO4
    Search eBioscience for ELISAs for REXO4 
    antibodies-online kits for REXO4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZR2

    ProtoNet protein and cluster: Q9GZR2

    1 Blocks protein domain: IPB006055 Exonuclease

    UniProtKB/Swiss-Prot: REXO4_HUMAN, Q9GZR2
    Similarity: Belongs to the REXO4 family
    Similarity: Contains 1 exonuclease domain


    Find genes that share domains with REXO4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10908561
    GO:0004527exonuclease activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with REXO4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for REXO4:
     High actin ratio cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for REXO4

    miRNA
    Products:
        
    miRTarBase miRNAs that target REXO4:
    hsa-mir-615-3p (MIRT040143), hsa-mir-484 (MIRT041926), hsa-mir-30a-5p (MIRT028599)

    Block miRNA regulation of human, mouse, rat REXO4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate REXO4
    SwitchGear 3'UTR luciferase reporter plasmidREXO4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for REXO4
    Predesigned siRNA for gene silencing in human, mouse, rat REXO4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REXO4

    Clone
    Products:
         
    OriGene clones in human, mouse for REXO4 (see all 7)
    OriGene ORF clones in mouse, rat for REXO4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REXO4 (NM_020385)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REXO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REXO4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for REXO4
    Browse ESI BIO Cell Lines and PureStem Progenitors for REXO4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    REXO4_HUMAN, Q9GZR2: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10908561
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with REXO4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REXO4
    Interactions:

        Search GeneGlobe Interaction Network for REXO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REXO4 (Q9GZR23 ENSP000003610104) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=2 STRING: ENSP00000343925
    ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NCBP2ENSP000003268064STRING: ENSP00000326806
    NOP58ENSP000002642794STRING: ENSP00000264279
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated NAS10908561

    Find genes that share ontologies with REXO4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REXO4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for REXO4 gene (4 alternative transcripts): 
    NM_001279349.1  NM_001279350.1  NM_001279351.1  NM_020385.3  

    Unigene Cluster for REXO4:

    REX4, RNA exonuclease 4 homolog (S. cerevisiae)
    Hs.438409  [show with all ESTs]
    Unigene Representative Sequence: NM_020385
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371942(uc011mde.2 uc004cdm.3 uc011mdf.2 uc004cdn.3)
    ENST00000454825 ENST00000494045 ENST00000478037 ENST00000445916 ENST00000371935

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat REXO4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate REXO4
    SwitchGear 3'UTR luciferase reporter plasmidREXO4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for REXO4
    Predesigned siRNA for gene silencing in human, mouse, rat REXO4
    Clone
    Products:
         
    OriGene clones in human, mouse for REXO4 (see all 7)
    OriGene ORF clones in mouse, rat for REXO4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REXO4 (NM_020385)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REXO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REXO4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for REXO4
    OriGene qSTAR qPCR primer pairs in human, mouse for REXO4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REXO4
      QuantiTect SYBR Green Assays in human, mouse, rat REXO4
      QuantiFast Probe-based Assays in human, mouse, rat REXO4

    Additional mRNA sequence: 

    AF273304.1 AF295774.1 AK000247.1 AK025493.1 AK295982.1 AK304547.1 AK310164.1 AK314333.1 
    AK315904.1 AL136894.1 BC009274.2 BC071691.1 

    17 DOTS entries:

    DT.111797  DT.100768830  DT.99964509  DT.100776447  DT.91745024  DT.86843527  DT.121151948  DT.99950045 
    DT.121151705  DT.121152196  DT.111798  DT.121151728  DT.100748566  DT.121152086  DT.100723270  DT.100782251 
    DT.91745023 

    Selected AceView cDNA sequences (see all 172):

    BQ227684 AL136894 CF131202 BQ882500 CA424354 BQ946299 CR591994 BQ439687 
    BU624183 BI334765 BQ006597 BM789004 N55313 AK025493 BQ890065 CA443749 
    BC071691 CR597347 AI365980 CF141366 BM983220 BU189945 AK000247 BQ049189 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for REXO4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                          -     -     -                                   -                                                   
    SP2:                                                                                                                              
    SP3:                          -     -     -     -                       -     -     -     -                                       
    SP4:                          -     -     -     -                             -                                                   
    SP5:                                                                          -                                                   


    ECgene alternative splicing isoforms for REXO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    REXO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACCTTGG
    REXO4 Expression
    About this image

    REXO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REXO4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438409
        Custom PCR Arrays for REXO4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for REXO4
    OriGene qSTAR qPCR primer pairs in human, mouse for REXO4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REXO4
    QuantiTect SYBR Green Assays in human, mouse, rat REXO4
    QuantiFast Probe-based Assays in human, mouse, rat REXO4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for REXO4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rexo41 , 5 REX4, RNA exonuclease 4 homolog (S. cerevisiae)1, 5 76.23(n)1
    73.1(a)1
      2 (19.13 cM)5
    2276561  NM_207234.21  NP_997117.21 
     269535635 
    chicken
    (Gallus gallus)
    Aves REXO41 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 63.44(n)
    62.96(a)
      417153  XM_415436.3  XP_415436.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525822 similar to Xenopus prevents mitotic catastrophe 2 homolog 74.59(n)    BC043958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-209e20.41 si:ch73-209e20.4 57.53(n)
    52.48(a)
      100333127  XM_002665867.2  XP_002665913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68336
    --
    34(a)
    1 ↔ 1
    3L(14044306-14045569)
    worm
    (Caenorhabditis elegans)
    Secernentea Y17G7B.126
    Protein Y17G7B.12 (Y17G7B.12) mRNA, complete cds
    34(a)
    1 ↔ 1
    II(12023757-12025932) WBGene00012465
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX4(YOL080C)4 Putative RNA exonuclease possibly involved in pre-rRNA more   --   15(181427-180558) 854075  NP_014561.1 
    rice
    (Oryza sativa)
    Liliopsida AK105467.12   -- 70.65(n)    AK105467.1 


    ENSEMBL Gene Tree for REXO4 (if available)
    TreeFam Gene Tree for REXO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for REXO4 gene
    ISG202  AEN2  ISG20L22  
    1 SIMAP similar gene for REXO4 using alignment to 1 protein entry:     REXO4_HUMAN:
    ISG20L2

    Find genes that share paralogs with REXO4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for REXO4
    PGOHUM00000246718


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for REXO4 (see all 163)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs413074261,2
    C,F--136271734(+) TCACCG/AAAGAT 1 -- ut312Minor allele frequency- A:0.06WA NA 238
    rs22854811,2
    C,F,A,H--136271744(+) TGGGCA/GGTGAC 1 -- ut31 ese313Minor allele frequency- G:0.05EA NA NS WA 2084
    rs22854821,2
    C,F,A,H--136271792(+) CACCTG/TGCCCA 1 -- ut31 ese310Minor allele frequency- T:0.06EA NS NA CSA WA 1660
    rs736604851,2
    C--136271802(+) AGGGGG/TTCAGC 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs783135541,2
    C,F--136271812(+) CAGTCG/AGTAAA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs22854831,2
    C,F--136271838(+) CCCATG/AGCCGT 1 -- ut31 ese35Minor allele frequency- A:0.15NA WA 244
    rs22854841,2
    C,F,A,H--136271841(+) ATGGCA/C/GGTCCC 2 -- ut31 ese39EA NS NA CSA WA 543
    rs1893063111,2
    --136271886(+) CATGGA/GCAGTA 1 -- ut310--------
    rs1813432261,2
    --136271958(+) CGCCCC/TTCTGC 1 -- ut310--------
    rs1849866371,2
    --136272009(+) GAGATA/GTGATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for REXO4 (136271186 - 136283164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for REXO4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv894081CNV Loss21882294
    dgv8328n71CNV Loss21882294
    dgv8325n71CNV Loss21882294
    nsv894082CNV Loss21882294
    nsv894080CNV Loss21882294
    nsv433408CNV Gain18776910
    nsv894086CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REXO4
    DNA2.0 Custom Variant and Variant Library Synthesis for REXO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602930    OMIM disorders: --


    Find genes that share disorders with REXO4           About GenesLikeMe

    Genetic Association Database (GAD): REXO4
    Human Genome Epidemiology (HuGE) Navigator: REXO4 (1 document)

    Export disorders for REXO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for REXO4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with REXO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. (PubMed id 9325058)1, 2, 3, 9 Kwiatkowska J.... Kwiatkowski D.J. (Genomics 1997)
    2. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PubMed id 20098615)1, 4 Wooten E.C....Huggins G.S. (PLoS ONE 2010)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity. (PubMed id 10908561)1, 2 Montano M.M.... Bianco N.R. (J. Biol. Chem. 2000)
    9. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57109 HGNC: 12820 AceView: XPMC2H Ensembl:ENSG00000148300 euGenes: HUgn57109
    ECgene: REXO4 H-InvDB: REXO4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for REXO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for REXO4 gene:
    Search GeneIP for patents involving REXO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for REXO4  
     OriGene qPCR primer pairs and template standards for REXO4   OriGene Protein Over-expression Lysate for REXO4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for REXO4  
     OriGene qSTAR qPCR primer pairs in human, mouse for REXO4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for REXO4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for REXO4   OriGene Custom Protein Services for REXO4  

     
     
     Block miRNA regulation of human, mouse, rat REXO4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing REXO4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REXO4 Predesigned siRNA for gene silencing in human, mouse, rat REXO4
     QuantiFast Probe-based Assays in human, mouse, rat REXO4 QuantiTect SYBR Green Assays in human, mouse, rat REXO4
     Custom PCR Arrays for REXO4 Search Chromatin IP Primers for REXO4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REXO4  Search GeneGlobe Interaction Network for REXO4
     Regulatory tfbs in REXO4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for REXO4 GenScript cDNA clones with any tag delivered in your preferred vector for REXO4
     GenScript Custom Assay Services for REXO4 GenScript Custom overexpressing Cell Line Services for REXO4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for REXO4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     REXO4 antibodies
     REXO4 proteins
     REXO4 lysates
     Antibodies for REXO4
     See all of Abcam's Antibodies, Kits and Proteins for REXO4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for REXO4
     Antibodies for REXO4
     ELISAs for REXO4
     CLIAs for REXO4



     Browse ESI BIO Cell Lines and PureStem Progenitors for REXO4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO4
     SwitchGear 3'UTR luciferase reporter plasmids for REXO4
     SwitchGear Promoter luciferase reporter plasmids for REXO4
     ThermoFisher Antibodies for REXO4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REXO4
     Browse compounds at ApexBio
     Search Addgene for plasmids for REXO4
      Search eBioscience for proteins for REXO4
      Search eBioscience for elisas for REXO4
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for REXO4
     antibodies-online antibodies for REXO4 (13 products)
     antibodies-online kits for REXO4 (4 products)
      Search antibodies-online for peptides for REXO4
     antibodies-online proteins for REXO4 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      REXO4 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4