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Aliases for REXO4 Gene

Aliases for REXO4 Gene

  • REX4 Homolog, 3'-5' Exonuclease 2
  • REX4 Homolog, 3-5 Exonuclease 2 3 5
  • Exonuclease XPMC2 3 4
  • XPMC2H 3 4
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog (Xenopus Laevis) 2
  • REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae) 2
  • Xenopus Prevents Mitotic Catastrophe 2 Homolog 3
  • Prevents Mitotic Catastrophe 2 Protein Homolog 4
  • Xenopus Prevents Mitotic Catatrophe 2 Homolog 2
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog 3
  • REX4, RNA Exonuclease 4 Homolog 3
  • RNA Exonuclease 4 3
  • EC 3.1.-.- 4
  • XPMC2 3
  • HPMC2 4
  • REX4 3
  • PMC2 4

External Ids for REXO4 Gene

Previous HGNC Symbols for REXO4 Gene

  • XPMC2H

Previous GeneCards Identifiers for REXO4 Gene

  • GC09M133301
  • GC09M135261
  • GC09M136271
  • GC09M105773

Summaries for REXO4 Gene

GeneCards Summary for REXO4 Gene

REXO4 (REX4 Homolog, 3'-5' Exonuclease) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ISG20L2.

Gene Wiki entry for REXO4 Gene

Additional gene information for REXO4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO4 Gene

Genomics for REXO4 Gene

Regulatory Elements for REXO4 Gene

Enhancers for REXO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H134162 1.2 ENCODE 21.2 -746.3 -746314 3.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 WDR5 BRD3 LOC100130548 REXO4 RPL7A SURF6 ENSG00000273249 MED22 COL5A1-AS1 ENSG00000273473
GH09H133029 1.2 ENCODE 18 +387.5 387466 2.5 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC ZC3H11A ZFP41 GLIS1 SETX TTF1 GTF3C5 TSC1 DDX31 MED22 GTF3C4 BRD3OS SPACA9 MED27
GH09H133485 1.2 Ensembl ENCODE 11.4 -68.3 -68263 1.1 RB1 ARID4B SIN3A ZNF2 RAD21 ZEB1 ZNF143 RCOR1 ATF7 CREM CACFD1 ADAMTS13 REXO4 ENSG00000230064 ENSG00000201451 SURF6 SURF4 STKLD1 MYMK ADAMTSL2
GH09H133854 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -438.1 -438099 3.7 ARID4B BRCA1 YY1 ELK1 ATF7 DEK REST NFIL3 MAFF GLIS1 REXO4 SLC2A6 RXRA GC09P133784 GC09M133930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around REXO4 on UCSC Golden Path with GeneCards custom track

Promoters for REXO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242584 72 1801 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D

Genomic Locations for REXO4 Gene

Genomic Locations for REXO4 Gene
12,115 bases
Minus strand

Genomic View for REXO4 Gene

Genes around REXO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO4 Gene

Proteins for REXO4 Gene

  • Protein details for REXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA exonuclease 4
    Protein Accession:
    Secondary Accessions:
    • B2RAT2
    • Q5T8S4
    • Q5T8S5
    • Q5T8S6
    • Q9GZW3

    Protein attributes for REXO4 Gene

    422 amino acids
    Molecular mass:
    46672 Da
    Quaternary structure:
    • Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.
    • Sequence=CAI12845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12847.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for REXO4 Gene


neXtProt entry for REXO4 Gene

Post-translational modifications for REXO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REXO4 Gene

No data available for DME Specific Peptides for REXO4 Gene

Domains & Families for REXO4 Gene

Gene Families for REXO4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REXO4 Gene

Suggested Antigen Peptide Sequences for REXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the REXO4 family.
  • Belongs to the REXO4 family.
genes like me logo Genes that share domains with REXO4: view

Function for REXO4 Gene

Enzyme Numbers (IUBMB) for REXO4 Gene

Phenotypes From GWAS Catalog for REXO4 Gene

Gene Ontology (GO) - Molecular Function for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 10908561
GO:0003723 RNA binding IDA 22658674
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with REXO4: view
genes like me logo Genes that share phenotypes with REXO4: view

Animal Model Products

miRNA for REXO4 Gene

miRTarBase miRNAs that target REXO4

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO4 Gene

Localization for REXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO4 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REXO4 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,NAS 10908561
GO:0005730 nucleolus IDA,IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with REXO4: view

Pathways & Interactions for REXO4 Gene

SuperPathways for REXO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 10908561
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO4: view

No data available for Pathways by source and SIGNOR curated interactions for REXO4 Gene

Drugs & Compounds for REXO4 Gene

No Compound Related Data Available

Transcripts for REXO4 Gene

Unigene Clusters for REXO4 Gene

REX4, RNA exonuclease 4 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - -
SP8: - -

Relevant External Links for REXO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REXO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REXO4 Gene

Protein differential expression in normal tissues from HIPED for REXO4 Gene

This gene is overexpressed in Lung (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REXO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of REXO4 Gene:


SOURCE GeneReport for Unigene cluster for REXO4 Gene:


Evidence on tissue expression from TISSUES for REXO4 Gene

  • Liver(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with REXO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO4 Gene

Orthologs for REXO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REXO4 33 34
  • 98.89 (n)
(Canis familiaris)
Mammalia REXO4 33 34
  • 80.2 (n)
(Rattus norvegicus)
Mammalia Rexo4 33
  • 76.86 (n)
(Mus musculus)
Mammalia Rexo4 33 16 34
  • 76.23 (n)
(Bos Taurus)
Mammalia REXO4 33 34
  • 74.26 (n)
(Monodelphis domestica)
Mammalia REXO4 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia REXO4 34
  • 43 (a)
(Gallus gallus)
Aves REXO4 33 34
  • 63.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo4 33
  • 60.16 (n)
Str.8400 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52582 33
(Danio rerio)
Actinopterygii si:ch73-209e20.4 33
  • 57.53 (n)
REXO4 34
  • 36 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13999 33
fruit fly
(Drosophila melanogaster)
Insecta CG6833 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea Y17G7B.12 34
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 34 36
  • 28 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4479 33
Species where no ortholog for REXO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO4 Gene

Gene Tree for REXO4 (if available)
Gene Tree for REXO4 (if available)

Paralogs for REXO4 Gene

Paralogs for REXO4 Gene

(1) SIMAP similar genes for REXO4 Gene using alignment to 1 proteins: Pseudogenes for REXO4 Gene

genes like me logo Genes that share paralogs with REXO4: view

Variants for REXO4 Gene

Sequence variations from dbSNP and Humsavar for REXO4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000072422 -- 133,414,106(+) TGCTC(C/T)GTCAC intron-variant, upstream-variant-2KB
rs1000486126 -- 133,408,399(+) AGTTA(A/C)AGTGA intron-variant
rs1000586973 -- 133,415,624(+) GTGGG(C/T)GCCAC intron-variant
rs1000673228 -- 133,410,743(+) TAGGG(C/T)GGGGT intron-variant
rs1000966775 -- 133,419,270(+) GCGGG(C/G)AGCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for REXO4 Gene

Variant ID Type Subtype PubMed ID
nsv433408 CNV gain 18776910
nsv1125319 OTHER inversion 24896259
esv2739138 CNV deletion 23290073

Variation tolerance for REXO4 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REXO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO4 Gene

Disorders for REXO4 Gene

Relevant External Links for REXO4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for REXO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO4 Gene

Publications for REXO4 Gene

  1. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. (PMID: 9325058) Kwiatkowska J … Kwiatkowski DJ (Genomics 1997) 2 3 4 22 60
  2. The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites. (PMID: 21602889) Krishnamurthy N … Montano MM (Oncogene 2011) 2 3 60
  3. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PMID: 20098615) Wooten EC … Huggins GS (PloS one 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60

Products for REXO4 Gene

Sources for REXO4 Gene

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