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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REXO2 Gene

protein-coding   GIFtS: 56
GCID: GC11P114311

RNA Exonuclease 2

(Previous names: REX2, RNA exonuclease 2 homolog (S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RNA Exonuclease 21 2     REX22
Small Fragment Nuclease2 3     Oligoribonuclease, Mitochondrial2
SFN2 3     REX2, RNA Exonuclease 2 Homolog2
RNA Exonuclease 2 Homolog2 3     EC 3.1.-.-3
RFN2 5     SMFN3
REX2, RNA Exonuclease 2 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 178511   Entrez Gene: 259962   Ensembl: ENSG000000760437   OMIM: 6071495   UniProtKB: Q9Y3B83   

Export aliases for REXO2 gene to outside databases

Previous GC identifers: GC11P113816 GC11P110238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REXO2 Gene:
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length)
single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and
recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to
UV-C-induced cell death through its role in the DNA repair process. (provided by RefSeq, Nov 2011)

GeneCards Summary for REXO2 Gene: 
REXO2 (RNA exonuclease 2) is a protein-coding gene. Diseases associated with REXO2 include t-cell leukemia, and tuberculosis. GO annotations related to this gene include 3'-5' exonuclease activity and nucleic acid binding.

UniProtKB/Swiss-Prot: ORN_HUMAN, Q9Y3B8
Function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily
nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling

Gene Wiki entry for REXO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REXO2 gene promoter:
         c-Fos   AML1a   AP-1   Nkx2-5   E47   HNF-1A   PPAR-alpha   HNF-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREXO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for REXO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REXO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.2

REXO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REXO2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P114311:  view genomic region     (about GC identifiers)

Start:
114,310,108 bp from pter      End:
114,321,001 bp from pter
Size:
10,894 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ORN_HUMAN, Q9Y3B8 (See protein sequence)
Recommended Name: Oligoribonuclease, mitochondrial precursor  
Size: 237 amino acids; 26833 Da
Cofactor: Manganese
Subunit: Homotetramer (Probable)
Subcellular location: Isoform 1: Mitochondrion
Subcellular location: Isoform 2: Nucleus
Secondary accessions: Q32Q18 Q53FT1 Q6FIC6 Q9UFY7
Alternative splicing: 2 isoforms:  Q9Y3B8-1   Q9Y3B8-2   

Explore the universe of human proteins at neXtProt for REXO2: NX_Q9Y3B8

Explore proteomics data for REXO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3B8

  • REXO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REXO2 Protein Expression
    REFSEQ proteins: NP_056338.2  
    ENSEMBL proteins: 
     ENSP00000265881   ENSP00000437460   ENSP00000440665   ENSP00000443842   ENSP00000442703  
     ENSP00000442380   ENSP00000441639   ENSP00000444421   ENSP00000441844   ENSP00000437380  
     ENSP00000446189   ENSP00000442162   ENSP00000441171  

    Human Recombinant Protein Products for REXO2: 
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    Novus Biologicals REXO2 Proteins
    Novus Biologicals REXO2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REXO2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005886plasma membrane IDA--

    REXO2 for ontologies           About GeneDecksing



    REXO2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR022894 Oligoribonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y3B8

    ProtoNet protein and cluster: Q9Y3B8

    2 Blocks protein domains:
    IPB006055 Exonuclease
    IPB013520 Exonuclease


    UniProtKB/Swiss-Prot: ORN_HUMAN, Q9Y3B8
    Similarity: Belongs to the oligoribonuclease family
    Similarity: Contains 1 exonuclease domain


    REXO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORN_HUMAN, Q9Y3B8
    Function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily
    nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling
    Enzyme regulation: Inhibited by adenosine 3',5'-bisphosphate

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004527exonuclease activity ----
    GO:00084083'-5' exonuclease activity IDA10851236
         
    REXO2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Rexo2 (no phenotypes)

    REXO2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for REXO2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REXO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REXO2 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REXO2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate REXO2:
    hsa-miR-631 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-33b hsa-miR-3661 hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidREXO2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of REXO2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for REXO2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for REXO2):
        Ribosome biogenesis in eukaryotes


    REXO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REXO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/74 Interacting proteins for REXO2 (Q9Y3B83 ENSP000002658814) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    DIS3Q9Y2L13, ENSP000003669974I2D: score=1 STRING: ENSP00000366997
    MPGP293723, ENSP000002194314I2D: score=1 STRING: ENSP00000219431
    EXOSC10Q017803, ENSP000003661354I2D: score=1 STRING: ENSP00000366135
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process IDA10851236
    GO:0009117nucleotide metabolic process TAS10851236

    REXO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for REXO2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REXO2 (ORN)

    1 HMDB Compound for REXO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--

    Search CenterWatch for drugs/clinical trials and news about REXO2 / ORN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REXO2 gene: 
    NM_015523.3  

    Unigene Clusters for REXO2:

    REX2, RNA exonuclease 2 homolog (S. cerevisiae)
    Hs.677190  [show with all ESTs], Hs.714231  [show with all ESTs]
    Unigene Representative Sequences: AK023498, BQ226060
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000265881(uc001poy.3 uc001poz.3) ENST00000544010 ENST00000544196
    ENST00000539754 ENST00000539275 ENST00000539333 ENST00000543243 ENST00000541703
    ENST00000543131 ENST00000538198 ENST00000539119 ENST00000542186 ENST00000544827
    ENST00000546316 ENST00000539788 ENST00000538403 ENST00000538791 ENST00000540492

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate REXO2:
    hsa-miR-631 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-33b hsa-miR-3661 hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidREXO2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REXO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REXO2
    Sirion Biotech Customized lentivirus for stable overexpression of REXO2 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REXO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REXO2

    Additional mRNA sequence: 

    AF151872.1 AK223200.1 AK312042.1 AL110239.1 BC003502.1 BC066947.1 BC105024.1 BC105026.1 
    BC107887.1 BC143701.1 CR533500.1 

    21 DOTS entries:

    DT.217144  DT.120750289  DT.120750316  DT.100798207  DT.120750331  DT.97823242  DT.102830270  DT.105053 
    DT.100676490  DT.430372  DT.97854580  DT.120750286  DT.40107223  DT.40132451  DT.92448075  DT.99982273 
    DT.100037974  DT.100037975  DT.120750325  DT.75196206  DT.95367244 

    24/477 AceView cDNA sequences (see all 477):

    BG678115 BE048515 Z38951 CB305480 AW299748 BM128593 AA316805 AI028092 
    AL110239 AI961467 CR592590 AW473916 BE709637 AU133957 AI990688 BQ478128 
    AA513768 BF448015 BQ015025 CF541298 N70887 AI249345 BP343229 BM673212 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for REXO2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                                            -     -           -     -                 -           -           -         
    SP2:                                            -     -           -     -     -           -           -           -         
    SP3:                                            -     -           -     -     -     -     -           -           -         
    SP4:                                                                                      -           -           -         
    SP5:                                -     -     -     -     -     -     -     -     -     -           -           -         


    ECgene alternative splicing isoforms for REXO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REXO2 expression in normal human tissues (normalized intensities)      REXO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGTCATT
    REXO2 Expression
    About this image


    REXO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Chorion (Extraembryonic Tissues)
             chorion villus cells   

    See REXO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REXO2

    SOURCE GeneReport for Unigene clusters: Hs.677190 Hs.714231
        SABiosciences Custom PCR Arrays for REXO2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REXO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for REXO2 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rexo21 , 5 REX2, RNA exonuclease 2 homolog (S. cerevisiae)1, 5 93.11(n)1
    94.09(a)1
      9 (26.42 cM)5
    1044441  NM_024233.31  NP_077195.21 
     484685145 
    chicken
    (Gallus gallus)
    Aves REXO21 REX2, RNA exonuclease 2 homolog (S. cerevisiae) 80.11(n)
    84.98(a)
      419761  XM_417900.3  XP_417900.1 
    lizard
    (Anolis carolinensis)
    Reptilia REXO26
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL343705.1(35171-41136)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92592 Xenopus laevis transcribed sequence with moderate similarity more 78.69(n)    BJ621647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731912 hypothetical protein MGC73191 77.13(n)   393717  BC059540.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102141 CG10214 56.7(n)
    54.02(a)
      42811  NM_142927.2  NP_651184.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C08B6.81 Protein C08B6.8 53.26(n)
    46.93(a)
      179411  NM_073205.3  NP_505606.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX2(YLR059C)4
    REX21
    3'-5' RNA exonuclease; involved in 3'-end processing more4
    Rex2p1
    52.49(n)1
    45.98(a)1
      12(260547-259738)4
    8507481, 4  NP_013160.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G269701 oligoribonuclease 53.75(n)
    51.12(a)
      817238  NM_001036349.1  NP_001031426.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g04655001 hypothetical protein 54.19(n)
    47.59(a)
      4329319  NM_001053345.1  NP_001046810.1 


    ENSEMBL Gene Tree for REXO2 (if available)
    TreeFam Gene Tree for REXO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/285 SNPs in REXO2 are shown (see all 285)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5645131,2
    C,F,A--114308109(+) CCCAGC/TTTATT 1 -- us2k1 tfbs33Minor allele frequency- T:0.40NA WA CSA 5
    rs1455127951,2
    --114308134(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1480633031,2
    C--114308135(+) GAGACC/GGGGTT 1 -- us2k10--------
    rs1417177241,2
    --114308180(+) ACCTCG/TTGATG 1 -- us2k10--------
    rs1505684801,2
    C--114308239(+) GTGCCG/TGGCCT 1 -- us2k10--------
    rs5662961,2
    C,F,A,H--114308307(+) ATGCAG/CACCAT 1 -- us2k126Minor allele frequency- C:0.37NS EA NA WA CSA 2732
    rs1395056481,2
    C--114308334(+) CACAAA/CTGAGT 1 -- us2k10--------
    rs1427716241,2
    --114308373(+) CAGGCA/CATGCA 1 -- us2k10--------
    rs735540921,2
    C,F--114308390(+) ATATAT/CACGCA 1 -- us2k12Minor allele frequency- C:0.02WA 120
    rs756637721,2
    F--114308429(+) ATCTGT/GGCATA 1 -- us2k11Minor allele frequency- G:0.33NA 6

    HapMap Linkage Disequilibrium report for REXO2 (114310108 - 114321001 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for REXO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898396CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607149    OMIM disorders: --

    3 diseases for REXO2:    About MalaCards
    t-cell leukemia    tuberculosis    leukemia


    REXO2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): REXO2
    Human Genome Epidemiology (HuGE) Navigator: REXO2 (1 document)

    Export disorders for REXO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REXO2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with REXO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of Escherichia coli Orn degrades small single- stranded RNA and DNA oligomers. (PubMed id 10851236)1, 2, 3, 9 Nguyen L.H.... Wilson D.M. III (2000)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. REXO2 is an oligoribonuclease active in human mitochon dria. (PubMed id 23741365)1, 3 Bruni F....Chrzanowska-Lightowlers Z.M. (2013)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. (PubMed id 16682444)2, 9 Mechold U....Danchin A. (2006)
    9. Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death. (PubMed id 15362935)1, 9 Ito S....Suzuki N. (2004)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25996 HGNC: 17851 AceView: DKFZP566E144andRBM7 Ensembl:ENSG00000076043 euGenes: HUgn25996
    ECgene: REXO2 Kegg: 25996 H-InvDB: REXO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REXO2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for REXO2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REXO2 gene:
    Search GeneIP for patents involving REXO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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