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Aliases for REXO2 Gene

Aliases for REXO2 Gene

  • RNA Exonuclease 2 2 3
  • RNA Exonuclease 2 Homolog 3 4
  • Small Fragment Nuclease 3 4
  • SFN 3 4
  • REX2, RNA Exonuclease 2 Homolog (S. Cerevisiae) 2
  • REX2, RNA Exonuclease 2 Homolog 3
  • EC 3.1.-.- 4
  • CGI-114 3
  • REX2 3
  • SMFN 4
  • RFN 3

External Ids for REXO2 Gene

Previous GeneCards Identifiers for REXO2 Gene

  • GC11P113816
  • GC11P114311
  • GC11P110238

Summaries for REXO2 Gene

Entrez Gene Summary for REXO2 Gene

  • This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]

GeneCards Summary for REXO2 Gene

REXO2 (RNA Exonuclease 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity.

UniProtKB/Swiss-Prot for REXO2 Gene

  • 3-to-5 exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.

Gene Wiki entry for REXO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO2 Gene

Genomics for REXO2 Gene

Regulatory Elements for REXO2 Gene

Genomic Location for REXO2 Gene

Chromosome:
11
Start:
114,439,386 bp from pter
End:
114,450,279 bp from pter
Size:
10,894 bases
Orientation:
Plus strand

Genomic View for REXO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REXO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO2 Gene

Proteins for REXO2 Gene

  • Protein details for REXO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B8-ORN_HUMAN
    Recommended name:
    Oligoribonuclease, mitochondrial
    Protein Accession:
    Q9Y3B8
    Secondary Accessions:
    • B2R532
    • Q32Q18
    • Q53FT1
    • Q6FIC6
    • Q9UFY7

    Protein attributes for REXO2 Gene

    Size:
    237 amino acids
    Molecular mass:
    26833 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Depletion of REXO2 by RNA interference causes a strong morphological phenotype showing disorganized network of punctate and granular mitochondria. Lack of REXO2 protein also causes a substantial decrease of mitochondrial nucleic acid content and impaired de novo mitochondrial protein synthesis

    Alternative splice isoforms for REXO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REXO2 Gene

Proteomics data for REXO2 Gene at MOPED

Post-translational modifications for REXO2 Gene

  • Ubiquitination at Lys 205
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for REXO2 Gene

Domains & Families for REXO2 Gene

Gene Families for REXO2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

Q9Y3B8

UniProtKB/Swiss-Prot:

ORN_HUMAN :
  • Contains 1 exonuclease domain.
  • Belongs to the oligoribonuclease family.
Domain:
  • Contains 1 exonuclease domain.
Family:
  • Belongs to the oligoribonuclease family.
genes like me logo Genes that share domains with REXO2: view

Function for REXO2 Gene

Molecular function for REXO2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by adenosine 3,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
3-to-5 exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.

Enzyme Numbers (IUBMB) for REXO2 Gene

Gene Ontology (GO) - Molecular Function for REXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IBA --
GO:0003676 nucleic acid binding IEA --
GO:0008408 3-5 exonuclease activity IDA 10851236
genes like me logo Genes that share ontologies with REXO2: view

Phenotypes for REXO2 Gene

GenomeRNAi human phenotypes for REXO2:
genes like me logo Genes that share phenotypes with REXO2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REXO2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for REXO2 Gene

Localization for REXO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO2 Gene

Isoform 1: Mitochondrion intermembrane space. Mitochondrion matrix.
Isoform 2: Nucleus.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REXO2 Gene COMPARTMENTS Subcellular localization image for REXO2 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for REXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with REXO2: view

Pathways & Interactions for REXO2 Gene

genes like me logo Genes that share pathways with REXO2: view

Gene Ontology (GO) - Biological Process for REXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IDA 10851236
GO:0009117 nucleotide metabolic process TAS 10851236
GO:0090305 nucleic acid phosphodiester bond hydrolysis IDA 10851236
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IBA --
genes like me logo Genes that share ontologies with REXO2: view

No data available for SIGNOR curated interactions for REXO2 Gene

Drugs & Compounds for REXO2 Gene

(1) Drugs for REXO2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 30
genes like me logo Genes that share compounds with REXO2: view

Transcripts for REXO2 Gene

Unigene Clusters for REXO2 Gene

REX2, RNA exonuclease 2 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REXO2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - -
SP11:
SP12:

Relevant External Links for REXO2 Gene

GeneLoc Exon Structure for
REXO2
ECgene alternative splicing isoforms for
REXO2

Expression for REXO2 Gene

mRNA expression in normal human tissues for REXO2 Gene

Protein differential expression in normal tissues from HIPED for REXO2 Gene

This gene is overexpressed in Skin (8.1), Uterus (7.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for REXO2 Gene



SOURCE GeneReport for Unigene cluster for REXO2 Gene Hs.677190

genes like me logo Genes that share expression patterns with REXO2: view

Protein tissue co-expression partners for REXO2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for REXO2 Gene

Orthologs for REXO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for REXO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia REXO2 35
  • 95.36 (n)
  • 97.05 (a)
REXO2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REXO2 35
  • 96.2 (n)
  • 97.46 (a)
REXO2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rexo2 35
  • 93.11 (n)
  • 94.09 (a)
Rexo2 16
Rexo2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia REXO2 35
  • 99.72 (n)
  • 100 (a)
REXO2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rexo2 35
  • 93.81 (n)
  • 94.51 (a)
oppossum
(Monodelphis domestica)
Mammalia REXO2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REXO2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves REXO2 35
  • 79.83 (n)
  • 84.98 (a)
REXO2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia REXO2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo2 35
  • 78.58 (n)
  • 88.08 (a)
Str.1796 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9259 35
zebrafish
(Danio rerio)
Actinopterygii smfn 35
  • 74.26 (n)
  • 82.78 (a)
zgc73191 35
smfn 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12624 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012804 35
  • 58.52 (n)
  • 55.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10214 35
  • 52.52 (n)
  • 48.78 (a)
CG10214 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C08B6.8 35
  • 53.11 (n)
  • 46.89 (a)
C08B6.8 36
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR217C 35
  • 47.05 (n)
  • 41.15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08998g 35
  • 48.17 (n)
  • 45.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX2 35
  • 52.44 (n)
  • 46.2 (a)
REX2 36
  • 32 (a)
OneToOne
REX2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26970 35
  • 54.1 (n)
  • 51.43 (a)
rice
(Oryza sativa)
Liliopsida Os02g0465500 35
  • 54.12 (n)
  • 47.31 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5073 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15100 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rex2 35
  • 52.79 (n)
  • 46.82 (a)
Species with no ortholog for REXO2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for REXO2 Gene

ENSEMBL:
Gene Tree for REXO2 (if available)
TreeFam:
Gene Tree for REXO2 (if available)

Paralogs for REXO2 Gene

No data available for Paralogs for REXO2 Gene

Variants for REXO2 Gene

Sequence variations from dbSNP and Humsavar for REXO2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9619 -- 114,450,201(+) TACAT(A/G)TATGC utr-variant-3-prime
rs15469 -- 114,450,226(-) CAAAA(A/G)AAATG utr-variant-3-prime
rs476200 -- 114,439,747(-) CCAGG(A/G)CGGGC intron-variant
rs502182 -- 114,443,658(+) AGTTT(C/T)CAGTG intron-variant
rs502254 -- 114,443,691(+) TATTT(G/T)GCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REXO2 Gene

Variant ID Type Subtype PubMed ID
nsv898396 CNV Gain 21882294

Variation tolerance for REXO2 Gene

Residual Variation Intolerance Score: 60.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REXO2 Gene

HapMap Linkage Disequilibrium report
REXO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO2 Gene

Disorders for REXO2 Gene

Relevant External Links for REXO2

Genetic Association Database (GAD)
REXO2
Human Genome Epidemiology (HuGE) Navigator
REXO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REXO2
genes like me logo Genes that share disorders with REXO2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO2 Gene

Publications for REXO2 Gene

  1. The human homolog of Escherichia coli Orn degrades small single- stranded RNA and DNA oligomers. (PMID: 10851236) Nguyen L.H. … Wilson D.M. III (J. Biol. Chem. 2000) 2 23 67
  2. REXO2 is an oligoribonuclease active in human mitochondria. (PMID: 23741365) Bruni F. … Chrzanowska-Lightowlers Z.M. (PLoS ONE 2013) 2 67
  3. Metal-binding and nuclease activity of an antimicrobial peptide analogue of the salivary histatin 5. (PMID: 17176059) Melino S. … Petruzzelli R. (Biochemistry 2006) 23 67
  4. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. (PMID: 16682444) Mechold U. … Danchin A. (Nucleic Acids Res. 2006) 23 67
  5. Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death. (PMID: 15362935) Ito S. … Suzuki N. (Photochem. Photobiol. 2004) 23 67

Products for REXO2 Gene

Sources for REXO2 Gene

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