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REXO2 Gene

protein-coding   GIFtS: 56
GCID: GC11P114311

RNA Exonuclease 2

(Previous names: REX2, RNA exonuclease 2 homolog (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Exonuclease 21 2     REX22
Small Fragment Nuclease2 3     Oligoribonuclease, Mitochondrial2
SFN2 3     REX2, RNA Exonuclease 2 Homolog2
RNA Exonuclease 2 Homolog2 3     EC 3.1.-.-3
RFN2 5     SMFN3
REX2, RNA Exonuclease 2 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 178511   Entrez Gene: 259962   Ensembl: ENSG000000760437   OMIM: 6071495   UniProtKB: Q9Y3B83   

Export aliases for REXO2 gene to outside databases

Previous GC identifers: GC11P113816 GC11P110238


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REXO2 Gene:
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length)
single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and
recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to
UV-C-induced cell death through its role in the DNA repair process. (provided by RefSeq, Nov 2011)

GeneCards Summary for REXO2 Gene:
REXO2 (RNA exonuclease 2) is a protein-coding gene. GO annotations related to this gene include 3'-5' exonuclease activity and nucleic acid binding.

UniProtKB/Swiss-Prot: ORN_HUMAN, Q9Y3B8
Function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily
nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling

Gene Wiki entry for REXO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the REXO2 gene promoter:
         c-Fos   AML1a   AP-1   Nkx2-5   E47   HNF-1A   PPAR-alpha   HNF-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREXO2 promoter sequence
   Search Chromatin IP Primers for REXO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REXO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.2

REXO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REXO2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P114311:  view genomic region     (about GC identifiers)

Start:
114,310,108 bp from pter      End:
114,321,001 bp from pter
Size:
10,894 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ORN_HUMAN, Q9Y3B8 (See protein sequence)
Recommended Name: Oligoribonuclease, mitochondrial precursor  
Size: 237 amino acids; 26833 Da
Cofactor: Manganese
Subunit: Homotetramer (Probable)
Secondary accessions: Q32Q18 Q53FT1 Q6FIC6 Q9UFY7
Alternative splicing: 2 isoforms:  Q9Y3B8-1   Q9Y3B8-2   

Explore the universe of human proteins at neXtProt for REXO2: NX_Q9Y3B8

Explore proteomics data for REXO2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys173, Lys205
  • Modification sites at PhosphoSitePlus

  • See REXO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056338.2  
    ENSEMBL proteins: 
     ENSP00000265881   ENSP00000437460   ENSP00000440665   ENSP00000443842   ENSP00000442703  
     ENSP00000442380   ENSP00000441639   ENSP00000444421   ENSP00000441844   ENSP00000437380  
     ENSP00000446189   ENSP00000442162   ENSP00000441171  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR022894 Oligoribonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y3B8

    ProtoNet protein and cluster: Q9Y3B8

    2 Blocks protein domains:
    IPB006055 Exonuclease
    IPB013520 Exonuclease


    UniProtKB/Swiss-Prot: ORN_HUMAN, Q9Y3B8
    Similarity: Belongs to the oligoribonuclease family
    Similarity: Contains 1 exonuclease domain


    Find genes that share domains with REXO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORN_HUMAN, Q9Y3B8
    Function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily
    nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling
    Enzyme regulation: Inhibited by adenosine 3',5'-bisphosphate

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004527exonuclease activity ----
    GO:00084083'-5' exonuclease activity IDA10851236
         
    Find genes that share ontologies with REXO2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Rexo2 (no phenotypes)

    Find genes that share phenotypes with REXO2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REXO2
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    miRTarBase miRNAs that target REXO2:
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    Block miRNA regulation of human, mouse, rat REXO2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate REXO2:
    hsa-miR-631 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-33b hsa-miR-3661 hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidREXO2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ORN_HUMAN, Q9Y3B8: Isoform 1: Mitochondrion
    ORN_HUMAN, Q9Y3B8: Isoform 2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    plasma membrane4
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005886plasma membrane ----
    GO:0005925focal adhesion IDA--

    Find genes that share ontologies with REXO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for REXO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with REXO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for REXO2
        p53 Signaling
    DNA Damage Induced 14-3-3Sigma Signaling


    1 Kegg Pathway  (Kegg details for REXO2):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REXO2
    Interactions:

        Search GeneGlobe Interaction Network for REXO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REXO2 (Q9Y3B83 ENSP000002658814) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPGP293723, ENSP000002194314I2D: score=1 STRING: ENSP00000219431
    YME1L1Q96TA23, ENSP000003184804I2D: score=1 STRING: ENSP00000318480
    EXOSC10Q017803, ENSP000003661354I2D: score=1 STRING: ENSP00000366135
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process IDA10851236
    GO:0009117nucleotide metabolic process TAS10851236
    GO:0090305nucleic acid phosphodiester bond hydrolysis IDA10851236

    Find genes that share ontologies with REXO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REXO2 (ORN)

    1 HMDB Compound for REXO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REXO2 gene: 
    NM_015523.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000265881(uc001poy.3 uc001poz.3) ENST00000544010 ENST00000544196
    ENST00000539754 ENST00000539275 ENST00000539333 ENST00000543243 ENST00000541703
    ENST00000543131 ENST00000538198 ENST00000539119 ENST00000542186 ENST00000544827
    ENST00000546316 ENST00000539788 ENST00000538403 ENST00000538791 ENST00000540492

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate REXO2:
    hsa-miR-631 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-33b hsa-miR-3661 hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidREXO2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat REXO2
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    Selected AceView cDNA sequences (see all 477):

    CR604871 CD674378 T25759 CA415570 BF445586 AW299748 BC003502 BE709637 
    AU133957 AA256468 AA766011 BF001680 AA454967 AI028092 CB138406 AI469939 
    CB158970 AI804409 AI249345 F06030 BI850488 CK823391 AA360499 BQ072673 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for REXO2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                                            -     -           -     -                 -           -           -         
    SP2:                                            -     -           -     -     -           -           -           -         
    SP3:                                            -     -           -     -     -     -     -           -           -         
    SP4:                                                                                      -           -           -         
    SP5:                                -     -     -     -     -     -     -     -     -     -           -           -         


    ECgene alternative splicing isoforms for REXO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REXO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGTCATT
    REXO2 Expression
    About this image


    REXO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    REXO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REXO2 Protein Expression
        Custom PCR Arrays for REXO2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for REXO2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rexo21 , 5 REX2, RNA exonuclease 2 homolog (S. cerevisiae)1, 5 93.11(n)1
    94.09(a)1
      9 (26.42 cM)5
    1044441  NM_024233.31  NP_077195.21 
     484685145 
    chicken
    (Gallus gallus)
    Aves REXO21 REX2, RNA exonuclease 2 homolog (S. cerevisiae) 79.83(n)
    84.98(a)
      419761  NM_001278120.1  NP_001265049.1 
    lizard
    (Anolis carolinensis)
    Reptilia REXO26
    RNA exonuclease 2
    69(a)
    1 ↔ 1
    GL343705.1(35171-41136)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92592 Xenopus laevis transcribed sequence with moderate similarity more 78.69(n)    BJ621647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731912 hypothetical protein MGC73191 77.13(n)   393717  BC059540.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102141 CG10214 52.52(n)
    48.78(a)
      42811  NM_142927.3  NP_651184.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C08B6.81 CELE_C08B6.8 53.11(n)
    46.89(a)
      179411  NM_001269256.1  NP_001256185.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX2(YLR059C)4
    REX21
    3'-5' RNA exonuclease; involved in 3'-end processing more4
    REX21
    52.44(n)1
    46.2(a)1
      12(260547-259738)4
    8507481, 4  NP_013160.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G269701 AT2G26970 54.1(n)
    51.43(a)
      817238  NM_179759.2  NP_850090.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g04655001 Os02g0465500 54.12(n)
    47.31(a)
      4329319  NM_001053345.1  NP_001046810.1 


    ENSEMBL Gene Tree for REXO2 (if available)
    TreeFam Gene Tree for REXO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REXO2 (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5645131,2
    C,F,A--114308109(+) CCCAGC/TTTATT 1 -- us2k1 tfbs33Minor allele frequency- T:0.40NA WA CSA 5
    rs1455127951,2
    --114308134(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1480633031,2
    C--114308135(+) GAGACC/GGGGTT 1 -- us2k10--------
    rs1417177241,2
    --114308180(+) ACCTCG/TTGATG 1 -- us2k10--------
    rs1505684801,2
    C--114308239(+) GTGCCG/TGGCCT 1 -- us2k10--------
    rs5662961,2
    C,F,A,H--114308307(+) ATGCAG/CACCAT 1 -- us2k126Minor allele frequency- C:0.37NS EA NA WA CSA 2732
    rs1395056481,2
    C--114308334(+) CACAAA/CTGAGT 1 -- us2k10--------
    rs1427716241,2
    --114308373(+) CAGGCA/CATGCA 1 -- us2k10--------
    rs735540921,2
    C,F--114308390(+) ATATAT/CACGCA 1 -- us2k12Minor allele frequency- C:0.02WA 120
    rs756637721,2
    F--114308429(+) ATCTGT/GGCATA 1 -- us2k11Minor allele frequency- G:0.33NA 6

    HapMap Linkage Disequilibrium report for REXO2 (114310108 - 114321001 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for REXO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898396CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REXO2
    DNA2.0 Custom Variant and Variant Library Synthesis for REXO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607149    OMIM disorders: --


    Find genes that share disorders with REXO2           About GenesLikeMe

    Genetic Association Database (GAD): REXO2
    Human Genome Epidemiology (HuGE) Navigator: REXO2 (1 document)

    Export disorders for REXO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REXO2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with REXO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of Escherichia coli Orn degrades small single- stranded RNA and DNA oligomers. (PubMed id 10851236)1, 2, 3, 9 Nguyen L.H.... Wilson D.M. III (J. Biol. Chem. 2000)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. REXO2 is an oligoribonuclease active in human mitochondria. (PubMed id 23741365)1, 3 Bruni F....Chrzanowska-Lightowlers Z.M. (PLoS ONE 2013)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. (PubMed id 16682444)2, 9 Mechold U.... Danchin A. (Nucleic Acids Res. 2006)
    9. Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death. (PubMed id 15362935)1, 9 Ito S....Suzuki N. (Photochem. Photobiol. 2004)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25996 HGNC: 17851 AceView: DKFZP566E144andRBM7 Ensembl:ENSG00000076043 euGenes: HUgn25996
    ECgene: REXO2 Kegg: 25996 H-InvDB: REXO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REXO2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for REXO2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REXO2 gene:
    Search GeneIP for patents involving REXO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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