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Aliases for REXO1 Gene

Aliases for REXO1 Gene

  • REX1, RNA Exonuclease 1 Homolog (S. Cerevisiae) 2 3
  • TCEB3BP1 3 4 6
  • ELOABP1 3 4 6
  • Transcription Elongation Factor B Polypeptide 3 Binding Protein 1 2 3
  • Transcription Elongation Factor B Polypeptide 3-Binding Protein 1 3 4
  • Elongin A Binding Protein 1 2 3
  • Elongin-A-Binding Protein 1 3 4
  • EloA-BP1 3 4
  • REX1 3 6
  • Elongin A-Binding Protein 1 3
  • RNA Exonuclease 1 Homolog 3
  • EC 3.1.-.- 4
  • KIAA1138 4

External Ids for REXO1 Gene

Previous HGNC Symbols for REXO1 Gene

  • TCEB3BP1

Previous GeneCards Identifiers for REXO1 Gene

  • GC19M001767
  • GC19M001586

Summaries for REXO1 Gene

GeneCards Summary for REXO1 Gene

REXO1 (REX1, RNA Exonuclease 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is LOC81691.

UniProtKB/Swiss-Prot for REXO1 Gene

  • Seems to have no detectable effect on transcription elongation in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO1 Gene

Genomics for REXO1 Gene

Regulatory Elements for REXO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for REXO1 Gene

Start:
1,815,246 bp from pter
End:
1,848,519 bp from pter
Size:
33,274 bases
Orientation:
Minus strand

Genomic View for REXO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO1 Gene

Proteins for REXO1 Gene

  • Protein details for REXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G1-REXO1_HUMAN
    Recommended name:
    RNA exonuclease 1 homolog
    Protein Accession:
    Q8N1G1
    Secondary Accessions:
    • Q9ULT2

    Protein attributes for REXO1 Gene

    Size:
    1221 amino acids
    Molecular mass:
    131510 Da
    Quaternary structure:
    • Interacts with TCEA2 and TCEB3.
    SequenceCaution:
    • Sequence=BAA86452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for REXO1 Gene

Proteomics data for REXO1 Gene at MOPED

Post-translational modifications for REXO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REXO1 Gene

No data available for DME Specific Peptides for REXO1 Gene

Domains for REXO1 Gene

Protein Domains for REXO1 Gene

Suggested Antigen Peptide Sequences for REXO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1G1

UniProtKB/Swiss-Prot:

REXO1_HUMAN :
  • Q8N1G1
Domain:
  • Contains 1 exonuclease domain.
Family:
  • Belongs to the REXO1/REXO3 family.
genes like me logo Genes that share domains with REXO1: view

No data available for Gene Families for REXO1 Gene

Function for REXO1 Gene

Molecular function for REXO1 Gene

UniProtKB/Swiss-Prot Function: Seems to have no detectable effect on transcription elongation in vitro.

Enzyme Numbers (IUBMB) for REXO1 Gene

Gene Ontology (GO) - Molecular Function for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with REXO1: view

Phenotypes for REXO1 Gene

GenomeRNAi human phenotypes for REXO1:
genes like me logo Genes that share phenotypes with REXO1: view

Animal Model Products

CRISPR Products

miRNA for REXO1 Gene

miRTarBase miRNAs that target REXO1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for REXO1 Gene

Localization for REXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REXO1 Gene COMPARTMENTS Subcellular localization image for REXO1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with REXO1: view

Pathways for REXO1 Gene

genes like me logo Genes that share pathways with REXO1: view

Pathways by source for REXO1 Gene

1 KEGG pathway for REXO1 Gene

Gene Ontology (GO) - Biological Process for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO1: view

Transcripts for REXO1 Gene

Unigene Clusters for REXO1 Gene

REX1, RNA exonuclease 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REXO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for REXO1 Gene

GeneLoc Exon Structure for
REXO1
ECgene alternative splicing isoforms for
REXO1

Expression for REXO1 Gene

mRNA expression in normal human tissues for REXO1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for REXO1 Gene

SOURCE GeneReport for Unigene cluster for REXO1 Gene Hs.192477

mRNA Expression by UniProt/SwissProt for REXO1 Gene

Q8N1G1-REXO1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with REXO1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for REXO1 Gene

Orthologs for REXO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REXO1 35
  • 98.68 (n)
  • 97.74 (a)
REXO1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia REXO1 35
  • 81.76 (n)
  • 80.95 (a)
REXO1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REXO1 35
  • 82.64 (n)
  • 81.02 (a)
REXO1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7104 36
  • 77 (a)
OneToMany
Rexo1 35
  • 79.12 (n)
  • 79.48 (a)
Rexo1 16
Rexo1 36
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rexo1 35
  • 78.82 (n)
  • 78.9 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 49 (a)
OneToMany
REXO1 35
  • 61.05 (n)
  • 57.7 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo1 35
  • 54.43 (n)
  • 54.49 (a)
Str.4225 35
zebrafish
(Danio rerio)
Actinopterygii rexo1 35
  • 53.44 (n)
  • 47.17 (a)
rexo1 36
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12877 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.33 36
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 36
  • 17 (a)
OneToMany
Species with no ortholog for REXO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO1 Gene

ENSEMBL:
Gene Tree for REXO1 (if available)
TreeFam:
Gene Tree for REXO1 (if available)

Paralogs for REXO1 Gene

Paralogs for REXO1 Gene

Selected SIMAP similar genes for REXO1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for REXO1 Gene

genes like me logo Genes that share paralogs with REXO1: view

Variants for REXO1 Gene

Sequence variations from dbSNP and Humsavar for REXO1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs732310 -- 1,833,339(-) GTTCC(A/C)CTGCC intron-variant
rs749109 -- 1,819,737(-) GTCCT(C/T)GCTGT intron-variant
rs893538 -- 1,818,953(+) TGGCA(C/G)AGCAG intron-variant
rs893539 -- 1,843,494(+) CAGAC(A/G)ACAAT intron-variant
rs893540 -- 1,843,627(+) ACCCC(C/T)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REXO1 Gene

Variant ID Type Subtype PubMed ID
dgv3583n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv910550 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3615n71 CNV Loss 21882294
dgv3616n71 CNV Loss 21882294
nsv910566 CNV Gain+Loss 21882294
dgv3617n71 CNV Loss 21882294
nsv910569 CNV Loss 21882294
dgv567n67 CNV Gain 20364138
nsv828384 CNV Gain 20364138
nsv520344 CNV Loss 19592680
dgv3618n71 CNV Loss 21882294
dgv3619n71 CNV Loss 21882294
dgv3620n71 CNV Loss 21882294
nsv910579 CNV Gain 21882294

Relevant External Links for REXO1 Gene

HapMap Linkage Disequilibrium report
REXO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO1 Gene

Disorders for REXO1 Gene

No disorders were found for REXO1 Gene.

No data available for UniProtKB/Swiss-Prot for REXO1 Gene

Publications for REXO1 Gene

  1. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PMID: 12943681) Tamura K. … Aso T. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for REXO1 Gene

Sources for REXO1 Gene

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