REXO1 Gene
protein-coding GIFtS : 54
GCID: GC19 M001815
REX1, RNA exonuclease 1 homolog (S. cerevisiae) (Previous name: transcription elongation factor B polypeptide 3 binding... ) (Previous symbol: TCEB3BP1 )
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Aliasesfor REXO1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases REX1, RNA Exonuclease 1 Homolog (S. Cerevisiae) 1 2 Transcription Elongation Factor B Polypeptide 3-Binding Protein 12 3 TCEB3BP11 2 3 5 REX12 5 EloA-BP11 2 3 Elongin A Binding Protein 12 ELOABP12 3 5 Elongin A-Binding Protein 12 Transcription Elongation Factor B Polypeptide 3 Binding Protein 11 2 RNA Exonuclease 1 Homolog2 KIAA11381 3 EC 3.1.-.-3 Elongin-A-Binding Protein 12 3
Export aliases for REXO1 gene to outside databases Previous GC identifers: GC19M001767 GC19M001586
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Summariesfor REXO1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: REXO1_HUMAN, Q8N1G1 Function : Seems to have no detectable effect on transcription elongation in vitro
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Genomic Viewsfor REXO1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011255.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the REXO1 gene promoter: STAT5B Pax-5 AP-1 p300 HTF MyoD Olf-1 STAT5A AP-4 N-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for REXO1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat REXO1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3 REXO1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M001815: view genomic region
(about GC identifiers )
Start:
1,815,245 bp from pter
End:
1,848,452 bp from pter
Size:
33,208 bases
Orientation:
minus strand
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Proteinsfor REXO1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: REXO1_HUMAN, Q8N1G1 (See
protein sequence )Recommended Name: RNA exonuclease 1 homolog Size : 1221 amino acids; 131510 Da
Subunit : Interacts with TCEA2 and TCEB3
Subcellular location : Nucleus
Sequence caution : Sequence=BAA86452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions : Q9ULT2Explore the universe of human proteins at neXtProt for REXO1: NX_Q8N1G1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N1G1 REXO1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_065746.3 ENSEMBL proteins: ENSP00000170168 ENSP00000468713 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
REXO1 for ontologies About GeneDecksing REXO1 Antibody Products: Assay Products for REXO1:
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Protein
Domains / Familiesfor REXO1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
REXO1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N1G1 ProtoNet protein and cluster: Q8N1G1
1 Blocks protein family : IPB006055 Exonuclease UniProtKB/Swiss-Prot: REXO1_HUMAN, Q8N1G1 Similarity : Belongs to the REXO1/REXO3 familySimilarity : Contains 1 exonuclease domain
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Functionfor REXO1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: REXO1_HUMAN, Q8N1G1 Function : Seems to have no detectable effect on transcription elongation in vitroEnzyme Number (IUBMB): EC 3.1.-.- 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REXO1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REXO1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: REXO1 (NM_020695 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REXO1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REXO1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0004527 exonuclease activity
IEA --
REXO1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for REXO1 :
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Pathways & Interactionsfor REXO1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ribosome biogenesis in eukaryotes
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for REXO1) :
REXO1 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REXO1 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5/9 Interacting proteins for REXO1 (Q8N1G1 2 , 3 ENSP00000170168 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 9 )About this table
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Drugs & Compoundsfor REXO1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for REXO1 Search CenterWatch for drugs/clinical trials and news about REXO1
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Transcriptsfor REXO1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for REXO1 gene: NM_020695.3 Unigene Cluster for REXO1:
REX1, RNA exonuclease 1 homolog (S. cerevisiae) Hs.192477 [show with all ESTs ] Unigene Representative Sequence: NM_020695 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000170168 (uc010dsq.3 uc002lua.4 uc010xgs.1 uc010dsp.1 uc010dsr.1 )ENST00000587404 ENST00000586291 ENST00000590936 ENST00000588743 ENST00000586343 ENST00000587524 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REXO1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REXO1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: REXO1 (NM_020695 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REXO1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REXO1
Additional cDNA sequence: AB032964.1 AK301030.1 AK301729.1 AK302362.1 AK308256.1 AK311255.1 BC016923.1 BC032244.1
6 DOTS entries : DT.443595 DT.110824
DT.432207 DT.91639889 DT.100836927 DT.100024633 24/122 AceView cDNA sequences (see all 122 ):
CA426735 BQ025936 BU155867 BQ022798 AW167723 BC016923 AI312127 AW006823 BG261281 BM664729 NM_020695 BX281350 AI393901 BM929263 CR593335 BG831108 AI312123 BE907963 AI915973 CB306400 BI093569 AI312125 AI091230 CD514879 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for REXO1 (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b SP1 :                   -                           SP2 :                   -                           SP3 :                                             SP4 :                                             SP5 :                                            
ECgene alternative splicing isoforms for REXO1
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Expression for REXO1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section REXO1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTCTTCCAA
About this image REXO1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See REXO1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for REXO1 SOURCE GeneReport for Unigene cluster: Hs.192477 UniProtKB/Swiss-Prot: REXO1_HUMAN, Q8N1G1 Tissue specificity : Ubiquitously expressed SABiosciences Custom PCR Arrays for REXO1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for REXO1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat REXO1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat REXO1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat REXO1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO1
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Orthologsfor REXO1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for REXO1 gene from 8/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for REXO1 (if available)TreeFam Gene Tree for REXO1 (if available)
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Paralogsfor REXO1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for REXO1 gene REXO1L2P 2 REXO1L11P 2 REXO1L1 2 LOC81691 2 4 SIMAP similar genes for REXO1 using alignment to 3 protein entries: REXO1_HUMAN (see all proteins ):REXO1L2P REXO1L1 REXO1L10P ISG20
REXO1 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for REXO1 PGOHUM00000233239
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Genomic Variantsfor REXO1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for REXO1 (1815245 - 1848452 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for REXO1 3 CNVs : 30062 30061 7191
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing REXO1
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Disorders
/ Diseasesfor REXO1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
REXO1 for disorders About MalaCards
REXO1 for disorders About GeneDecksing
OMIM gene information: 609614
OMIM disorders : --Export disorders for REXO1 gene to outside databases
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Publicationsfor REXO1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for REXO1 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with REXO1) Utopia : connect your pdf to the dynamic world of online information
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461) 1 , 2 , 3 Hirosawa M.... Ohara O. (1999) Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PubMed id 12943681) 1 , 2 , 9 Tamura K.... Aso T. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. (PubMed id 22596162) 1 Gontan C....Gribnau J. (2012) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) REX-1 expression and p38 MAPK activation status can d etermine proliferation/differentiation fates in human mesenchymal stem cells. (PubMed id 20463961) 1 Bhandari D.R....Kang K.S. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 2 Cantin G.T....Yates J.R. III (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005)
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External Searches for REXO1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing REXO1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing REXO1 gene
(According to HUGE )
About This Section
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Specialized Databases showing REXO1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for REXO1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for REXO1 gene: Search GeneIP for patents involving REXO1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor REXO1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for REXO1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for REXO1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for REXO1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for REXO1 OriGene 3'-UTR Clone for REXO1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REXO1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REXO1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for REXO1 OriGene Custom Protein Services for REXO1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REXO1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing REXO1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat REXO1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat REXO1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat REXO1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat REXO1
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REXO1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REXO1
Search ThermoFisher Antibodies for REXO1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REXO1
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Aliases for REXO1
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Disorders / Diseases for REXO1
Domains / Families for REXO1
Drugs / Compounds for REXO1
Expression for REXO1
Function for REXO1
Genomic Views for REXO1
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Orthologs for REXO1
Paralogs for REXO1
Pathways / Interactions for REXO1
Products for REXO1
Proteins for REXO1
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Search Box for REXO1
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Transcripts for REXO1
Variants for REXO1
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