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Aliases for REXO1 Gene

Aliases for REXO1 Gene

  • RNA Exonuclease 1 Homolog 2 3 5
  • Transcription Elongation Factor B Polypeptide 3-Binding Protein 1 3 4
  • Elongin-A-Binding Protein 1 3 4
  • EloA-BP1 3 4
  • TCEB3BP1 3 4
  • ELOABP1 3 4
  • Transcription Elongation Factor B Polypeptide 3 Binding Protein 1 2
  • REX1, RNA Exonuclease 1 Homolog (S. Cerevisiae) 2
  • REX1, RNA Exonuclease 1 Homolog 3
  • Elongin A Binding Protein 1 2
  • EC 3.1.-.- 4
  • KIAA1138 4
  • REX1 3

External Ids for REXO1 Gene

Previous HGNC Symbols for REXO1 Gene

  • TCEB3BP1

Previous GeneCards Identifiers for REXO1 Gene

  • GC19M001767
  • GC19M001586

Summaries for REXO1 Gene

GeneCards Summary for REXO1 Gene

REXO1 (RNA Exonuclease 1 Homolog) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is LOC81691.

UniProtKB/Swiss-Prot for REXO1 Gene

  • Seems to have no detectable effect on transcription elongation in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO1 Gene

Genomics for REXO1 Gene

Regulatory Elements for REXO1 Gene

Enhancers for REXO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001744 1.6 FANTOM5 Ensembl ENCODE 12.4 +100.6 100649 7.1 HDGF PKNOX1 ARNT ZNF2 YY1 ZNF766 CBX5 FOS KLF13 ZNF263 SCAMP4 CIRBP ENSG00000266990 LINC01775 C19orf24 ATP8B3 MIR1909 REXO1 TMEM259 TCF3
GH19F001667 1.5 FANTOM5 Ensembl ENCODE 11.8 +180.1 180059 2.5 HDGF GLI4 YBX1 ZBTB40 ZNF48 ZNF155 ZEB1 ZNF335 GLIS2 ZNF366 SF3A2 TMEM259 CIRBP LOC100288123 RNU6-1223P ATP8B3 MIR1909 REXO1 RPS15 GRIN3B
GH19F001725 1.5 FANTOM5 Ensembl ENCODE 11.8 +122.6 122646 1.3 ELF3 ZNF133 ZFP64 DEAF1 ARID4B ZNF48 ZBTB40 KAT2B ZNF335 ZNF121 ONECUT3 ATP8B3 MIR1909 REXO1 RNU6-1223P TCF3 APC2 MUM1 CBARP ENSG00000275642
GH19F001671 1.3 Ensembl ENCODE 11.8 +176.3 176329 1.1 HDGF ATF1 PKNOX1 ARNT ARID4B GLI4 ZNF2 GLIS2 ZNF143 KLF7 CFD RNU6-1223P ATP8B3 MIR1909 REXO1 MIDN GC19P001669 GC19P001681 GC19P001682
GH19F001928 1.2 Ensembl ENCODE 12.3 -81.3 -81302 1.7 PKNOX1 ZNF133 ARID4B SIN3A ZSCAN9 ZNF2 RAD21 ZNF48 ZNF335 ZNF766 BTBD2 TMEM259 SF3A2 MIR1909 REXO1 KLF16 ATP8B3 LOC100288123 ENSG00000267317 CSNK1G2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around REXO1 on UCSC Golden Path with GeneCards custom track

Promoters for REXO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000341628 288 2001 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for REXO1 Gene

Chromosome:
19
Start:
1,815,246 bp from pter
End:
1,848,488 bp from pter
Size:
33,243 bases
Orientation:
Minus strand

Genomic View for REXO1 Gene

Genes around REXO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO1 Gene

Proteins for REXO1 Gene

  • Protein details for REXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G1-REXO1_HUMAN
    Recommended name:
    RNA exonuclease 1 homolog
    Protein Accession:
    Q8N1G1
    Secondary Accessions:
    • Q9ULT2

    Protein attributes for REXO1 Gene

    Size:
    1221 amino acids
    Molecular mass:
    131510 Da
    Quaternary structure:
    • Interacts with TCEA2 and TCEB3.
    • Interacts with TCEA2 and TCEB3.
    SequenceCaution:
    • Sequence=BAA86452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for REXO1 Gene

Post-translational modifications for REXO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for REXO1 Gene

Domains & Families for REXO1 Gene

Gene Families for REXO1 Gene

Protein Domains for REXO1 Gene

Suggested Antigen Peptide Sequences for REXO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1G1

UniProtKB/Swiss-Prot:

REXO1_HUMAN :
  • Contains 1 exonuclease domain.
  • Belongs to the REXO1/REXO3 family.
Domain:
  • Contains 1 exonuclease domain.
Family:
  • Belongs to the REXO1/REXO3 family.
genes like me logo Genes that share domains with REXO1: view

Function for REXO1 Gene

Molecular function for REXO1 Gene

UniProtKB/Swiss-Prot Function:
Seems to have no detectable effect on transcription elongation in vitro.

Enzyme Numbers (IUBMB) for REXO1 Gene

Gene Ontology (GO) - Molecular Function for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with REXO1: view

Phenotypes for REXO1 Gene

genes like me logo Genes that share phenotypes with REXO1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO1 Gene

Localization for REXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REXO1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with REXO1: view

Pathways & Interactions for REXO1 Gene

genes like me logo Genes that share pathways with REXO1: view

Pathways by source for REXO1 Gene

1 KEGG pathway for REXO1 Gene

Gene Ontology (GO) - Biological Process for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO1: view

No data available for SIGNOR curated interactions for REXO1 Gene

Transcripts for REXO1 Gene

Unigene Clusters for REXO1 Gene

REX1, RNA exonuclease 1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for REXO1 Gene

GeneLoc Exon Structure for
REXO1
ECgene alternative splicing isoforms for
REXO1

Expression for REXO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for REXO1 Gene

Protein differential expression in normal tissues from HIPED for REXO1 Gene

This gene is overexpressed in Monocytes (48.4) and Heart (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REXO1 Gene



Protein tissue co-expression partners for REXO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of REXO1 Gene:

REXO1

SOURCE GeneReport for Unigene cluster for REXO1 Gene:

Hs.192477

mRNA Expression by UniProt/SwissProt for REXO1 Gene:

Q8N1G1-REXO1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with REXO1: view

No data available for mRNA differential expression in normal tissues for REXO1 Gene

Orthologs for REXO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REXO1 34 35
  • 98.68 (n)
dog
(Canis familiaris)
Mammalia REXO1 34 35
  • 82.64 (n)
cow
(Bos Taurus)
Mammalia REXO1 34 35
  • 81.76 (n)
mouse
(Mus musculus)
Mammalia Rexo1 34 16 35
  • 79.12 (n)
Gm7104 35
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rexo1 34
  • 78.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves REXO1 34
  • 61.05 (n)
-- 35
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo1 34
  • 54.43 (n)
Str.4225 34
zebrafish
(Danio rerio)
Actinopterygii rexo1 34 35
  • 53.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12877 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.33 35
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 35
  • 17 (a)
OneToMany
Species where no ortholog for REXO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO1 Gene

ENSEMBL:
Gene Tree for REXO1 (if available)
TreeFam:
Gene Tree for REXO1 (if available)

Paralogs for REXO1 Gene

Paralogs for REXO1 Gene

(3) SIMAP similar genes for REXO1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with REXO1: view

Variants for REXO1 Gene

Sequence variations from dbSNP and Humsavar for REXO1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402394 -- 1,838,590(+) aactc(A/C/G)ggagg intron-variant
rs10405979 -- 1,840,268(+) GAAGG(A/G)AAGTG intron-variant
rs10409758 -- 1,835,953(+) ACCGC(A/C)TCTCC intron-variant
rs10411249 -- 1,839,456(+) CGCTG(C/T)CCCTC intron-variant
rs10413639 -- 1,826,742(+) CGGGC(C/T)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REXO1 Gene

Variant ID Type Subtype PubMed ID
nsv953942 CNV deletion 24416366
nsv828384 CNV gain 20364138
nsv578338 CNV loss 21841781
nsv578337 CNV gain 21841781
nsv520344 CNV loss 19592680
nsv470107 CNV loss 18288195
nsv1160560 CNV deletion 26073780
esv3893156 CNV loss 25118596
esv3643411 CNV loss 21293372
esv32942 CNV gain+loss 17666407
dgv567n67 CNV gain 20364138

Variation tolerance for REXO1 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.73; 97.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REXO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REXO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO1 Gene

Disorders for REXO1 Gene

Relevant External Links for REXO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REXO1

No disorders were found for REXO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO1 Gene

Publications for REXO1 Gene

  1. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PMID: 12943681) Tamura K. … Aso T. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for REXO1 Gene

Sources for REXO1 Gene

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