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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

REV3L Gene

protein-coding GIFtS: 61
GCID: GC06M111665

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

(Previous names: REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase...)

Explore 26 diseases affiliated with
REV3L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit¹ ²		REV3-Like, Catalytic Subunit Of DNA Polymerase Zeta (Yeast)¹
POLZ¹ ² ³ ⁵		DNA Polymerase Zeta Catalytic Subunit²
REV3¹ ² ³ ⁵		Rev-3, Yeast, Homolog-Like (Polymerase, DNA, Zeta)²
HREV3¹		REV3-Like¹
EC 2.7.7.7³ ⁸		Protein Reversionless 3-Like³
REV3 (Yeast Homolog)-Like, Catalytic Subunit Of DNA Polymerase Zeta¹		EC 2.7.7⁸

External Ids:	HGNC: 9968¹	Entrez Gene: 5980²	Ensembl: ENSG00000009413⁷	OMIM: 602776⁵	UniProtKB: O60673³

Export aliases for REV3L gene to outside databases

Previous GC identifers: GC06M111455 GC06M111643 GC06M111726 GC06M109191

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673

Function: Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis

Gene Wiki entry for REV3L

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the REV3L gene promoter:
GR FOXO3 POU6F1 (c2) FOXO3b Meis-1b FOXO3a GR-alpha Meis-1a Ik-1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): REV3L promoter sequence

Search SABiosciences Chromatin IP Primers for REV3L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REV3L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q22

REV3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REV3L gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M111665: view genomic region (about GC identifiers)

Start:	111,620,234 bp from pter	End:	111,804,918 bp from pter
Size:	184,685 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673 (See protein sequence)

Recommended Name: DNA polymerase zeta catalytic subunit

Size: 3130 amino acids; 352776 Da

Cofactor: Binds 1 4Fe-4S cluster (By similarity)

Subunit: Interacts with MAD2L2

Subcellular location: Nucleus (Potential)

3 PDB 3D structures from and Proteopedia for REV3L:

3ABD (3D)

3ABE (3D)

3VU7 (3D)

Secondary accessions: O43214 Q5TC33

Alternative splicing: 2 isoforms: O60673-1 O60673-2

Explore the universe of human proteins at neXtProt for REV3L: NX_O60673

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60673

2 DME Specific Peptides for REV3L (O60673)

ARVVYGD

KGIETVRRD

REV3L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002903.3

ENSEMBL proteins:

ENSP00000393184 ENSP00000391605 ENSP00000357792 ENSP00000357795 ENSP00000400600

ENSP00000351697 ENSP00000402003

Human Recombinant Protein Products:

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	Novus Biologicals REV3L Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IBA	--
GO:0005694	chromosome	IBA	--
GO:0016035	zeta DNA polymerase complex	IDA	--

REV3L for ontologies About GeneDecksing

REV3L Antibody Products:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

REV3L for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR025687 Znf-C4pol

IPR006172 DNA-dir_DNA_pol_B

IPR006133 DNA-dir_DNA_pol_B_exonuc

IPR006134 DNA-dir_DNA_pol_B_multi_dom

IPR023211 DNA_pol_palm_dom

Graphical View of Domain Structure for InterPro Entry O60673

ProtoNet protein and cluster: O60673

1 Blocks protein family: IPB006134 DNA polymerase B domain

UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673

Domain: Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal

part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis

Domain: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes (By similarity)

Similarity: Belongs to the DNA polymerase type-B family

Similarity: Contains 1 CysA-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673

Function: Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis

Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

Genatlas biochemistry entry for REV3L:

DNA polymerase,zeta,>10kDa,catalytic subunit,S cerevisiae REV3 homolog,involved in reduction of DNA

damage,tissue-specific

Enzyme Numbers (IUBMB): EC 2.7.7.7¹ ² EC 2.7.7²

miRNA Products:		OriGene 3'-UTR Clone: REV3L Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REV3L
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		hsa-miR-124* hsa-miR-4317 hsa-miR-548j hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-548k hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: REV3L 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REV3L

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0003887	DNA-directed DNA polymerase activity	IBA	--
GO:0008408	NOT 3'-5' exonuclease activity	IBA	--
GO:0046872	metal ion binding	IEA	--

REV3L for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for REV3L:

Decreased viability with cispl

Animal Models:
Mouse knock-outs for REV3L: Rev3l^tm1Esp Rev3l^tm1Ndew Rev3l^tm1Kaji Rev3l^tm1Msn Rev3l^tm1.1Rsky
11 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Rev3l):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	mortality/aging	nervous system
tumorigenesis

REV3L for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for REV3L):

Metabolic pathways

REV3L for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for REV3L

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/15 Interacting proteins for REV3L (O60673^{2, 3} ENSP00000351697⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAD2L2	Q9UI95²^,³, ENSP00000235310⁴	MINT-8385495 MINT-8385803 MINT-8385849 MINT-8385833 MINT-8385442 I2D: score=3 STRING: ENSP00000235310
REV1	Q9UBZ9², ENSP00000258428⁴	MINT-8385495 MINT-8385803 MINT-8385833 MINT-8385442 STRING: ENSP00000258428
CHEK2	O96017³, ENSP00000372023⁴	I2D: score=1 STRING: ENSP00000372023
HDAC4	P56524³, ENSP00000264606⁴	I2D: score=1 STRING: ENSP00000264606
PMS1	P54277³, ENSP00000406490⁴	I2D: score=1 STRING: ENSP00000406490

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006261	DNA-dependent DNA replication	TAS	9618506
GO:0006281	DNA repair	--	--
GO:0006297	NOT nucleotide-excision repair, DNA gap filling	IBA	--
GO:0019985	translesion synthesis	IBA	--

REV3L for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

REV3L for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for REV3L

6 HMDB Compounds for REV3L About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--
Thymidine 5'-triphosphate	2'-Deoxythymidine 5'-triphosphate (see all 13)	365-08-2	--
dATP	2'-Deoxy-5'-ATP (see all 8)	1927-31-7	--
dCTP	2'-deoxycytidine-5'-triphosphate (see all 4)	2056-98-6	--
dGTP	2'-Deoxyguanosine 5'-triphosphate (see all 4)	2564-35-4	--

2 Novoseek chemical compound relationships for REV3L gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cytidine	36.4	1	15198729 (1)
cisplatin	19.5	19	15520212 (5), 16428501 (5)

Search CenterWatch for drugs/clinical trials and news about REV3L / DPOLZ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for REV3L gene:

NM_002912.3

Unigene Cluster for REV3L:

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

Hs.232021 [show with all ESTs]

Unigene Representative Sequence: AF078695

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000422377(uc003puy.4 uc003pux.4 uc003puz.4) ENST00000462119(uc003puw.4)

ENST00000434009 ENST00000368802 ENST00000368805(uc003pva.1) ENST00000413831

ENST00000492520 ENST00000467500 ENST00000470871 ENST00000460981 ENST00000494858

ENST00000358835 ENST00000435970

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REV3L
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate REV3L (see all 63):
		hsa-miR-124* hsa-miR-4317 hsa-miR-548j hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-548k hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: REV3L 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: REV3L (NM_002912)
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Additional cDNA sequence:

AB209256.1 AF004713.1 AF035537.1 AF058701.1 AF071798.1 AF078695.1 AF157476.1 AF179428.1

AF179429.1 AF303220.1 AK310949.1 AL096744.1 BC035823.1 BC038986.1

22 DOTS entries:

DT.95169408 DT.91839106 DT.100751947 DT.95169406 DT.100751948 DT.107807 DT.416663 DT.100751949

DT.121340284 DT.40122352 DT.86836533 DT.95245790 DT.92023460 DT.97855536 DT.100740709 DT.65287234

DT.91882815 DT.91927451 DT.92426155 DT.97780664 DT.97810487 DT.99948008

24/159 AceView cDNA sequences (see all 159):

H38497 BM459612 AA435818 BG403781 AF179429 BM806800 AF179428 AW958271

BM854960 BP372244 AF035537 AA694048 BM068795 BG568719 CK904633 CD674579

AA334113 AU280275 BG941645 BM461441 AF157476 AA308432 R34909 AA448067

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for REV3L (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19a	·	19b	^
SP1:
SP2:							-		-		-		-
SP3:																																																	-		-
SP4:
SP5:											-		-

ExUns:	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24	^	25a	·	25b	^	26a	·	26b	^	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33a	·	33b	·	33c	^	34	^	35
SP1:			-
SP2:
SP3:			-
SP4:																																							-
SP5:

ECgene alternative splicing isoforms for REV3L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

REV3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACTTCCC

About this image

REV3L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See REV3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REV3L

SOURCE GeneReport for Unigene cluster: Hs.232021

UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for REV3L

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REV3L

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for REV3L gene from 10/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	REV3L¹	REV3-like, catalytic subunit of DNA polymerase zeta more	75.85(n) 73.62(a)		428622 XM_426179.3 XP_426179.3
lizard (Anolis carolinensis)	Reptilia	REV3L⁶	--	63(a)	1 ↔ 1	1(192207952-192276827)
African clawed frog (Xenopus laevis)	Amphibia	48050934²	--	78.67(n)		48050934
zebrafish (Danio rerio)	Actinopterygii	57044779²	--	73.35(n)		386961 57044779
fruit fly (Drosophila melanogaster)	Insecta	mus205^{1 , 3}	DNA replication zeta DNA polymerase³ mutagen-sensitive 205¹	52(a)³ 49.66(n)¹ 46.3(a)¹		2 43E17³ 47186¹ NM_080142.2¹ NP_524881.2¹
worm (Caenorhabditis elegans)	Secernentea	Y37B11A.2^{1 , 3}	Protein Y37B11A.2¹	34(a)³ 48.19(n)¹ 37.42(a)¹		III(5846520-5854329)³ 175809¹ NM_065847.3¹ NP_498248.2¹
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AAL099C¹	AAL099Cp	47.27(n) 37.59(a)		4618518 NM_207796.1 NP_982443.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ATREV3⁶	DNA polymerase zeta subunit	27(a)	1 ↔ 1	1(25287707-25296937)
rice (Oryza sativa)	Liliopsida	Os.33702²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.27(n)		NM_186110.1
E. coli (Escherichia coli)	Gamma proteobacteria	polB⁶	DNA polymerase II	18(a)	possible ortholog	Chromosome(63429-65780)

ENSEMBL Gene Tree for REV3L (if available)
TreeFam Gene Tree for REV3L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for REV3L gene

KIAA2022²

REV3L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17511646^1,2	C,F,	--	111619826(-)	`CACCTG/AGTTAT`	1	--	int¹		2		NS EA	240
rs17540360^1,2	C,	--	111619852(-)	`AGTTAGTTA/- TTATT`	1	--	int¹		1		NS	118
rs143536561^1,2		--	111619893(+)	`AAAAAC/TTGGCA`	1	--	int¹		0	--	--	--	--
rs25639^1,2	C,F,	--	111619950(+)	`ATTAA-/TAAT TAATT`	1	--	int¹		1		NS	172
rs35570834^1,2	C	--	111619956(+)	`AATTAATTA/- TATCA`	1	--	int¹		1		NA	2
rs17540346^1,2	C,F	--	111619990(-)	`TTGTT-/TGTT AGTAG`	1	--	int¹		1		NS	144
rs148353761^1,2	C,	--	111619990(+)	`CTACT-/AACA AACAA`	1	--	int¹		0	--	--	--	--
rs56847290^1,2	C	--	111619991(+)	`AACAA-/ACAA GTACA`	1	--	int¹		1		NA	2
rs240959^1,2	C,F,A,H,	--	111620013(-)	`AGAGAT/GTTTTA`	1	--	int¹		12		MN NS EA NA CSA WA	1138
rs144075968^1,2	C,	--	111620061(+)	`TGCCC-/TTTTTTT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for REV3L (111620234 - 111804918 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for REV3L: --
Human Gene Mutation Database (HGMD): REV3L

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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REV3L for disorders           About GeneDecksing

OMIM gene information: 602776    OMIM disorders: --

20/26 diseases for REV3L (see all 26):    About MalaCards

chronic progressive external ophthalmoplegia human immunodeficiency virus infectious disease mutagen sensitivity skin tag

xeroderma pigmentosum herpes zoster alpers syndrome chronic lymphocytic leukemia

lymphocytic leukemia ophthalmoplegia stomach cancer colon carcinoma

hepatitis b vaccinia encephalitis ovarian carcinoma

hepatocellular carcinoma gastric cancer carcinoma leukemia

3 Novoseek disease relationships for REV3L gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	20.8	3	16428501 (2)
tumors	0	5	10660610 (1), 9635887 (1), 11115544 (1)
cancer	0	1	16428501 (1)

Human Genome Epidemiology (HuGE) Navigator: REV3L (7 documents)

Export disorders for REV3L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for REV3L gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with REV3L)

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A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. (PubMed id 9618506)^{1, 2, 3, 9} Gibbs P.E.M.... Lawrence C.W. (1998)
Alternative splicing, genomic structure, and fine chromosome localization of REV3L. (PubMed id 9925914)^{1, 2, 3, 9} Morelli C.... Croce C.M. (1998)
A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans. (PubMed id 10102035)^{1, 2, 9} Lin W.... Wang Z. (1999)
Crystal structure of human REV7 in complex with a hum an REV3 fragment and structural implication of the interaction between DNA poly merase zeta and REV1. (PubMed id 20164194)^{1, 2, 9} Hara K....Sato M. (2010)
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. (PubMed id 10660610)^{1, 2, 9} Murakumo Y....Fishel R. (2000)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues. (PubMed id 11115544)^{1, 9} Kawamura K....Tagawa M. (2001)
Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis. (PubMed id 12717825)^{1, 9} Zhu F....Yu Y.N. (2003)
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. (PubMed id 11485998)^{1, 9} Murakumo Y.... Takahashi M. (2001)
Purification, crystallization and initial X-ray diffr action study of human REV7 in complex with a REV3 fragment. (PubMed id 20054135)^{1, 9} Hara K....Hashimoto H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5980	HGNC: 9968	AceView: REV3L	Ensembl:ENSG00000009413	euGenes: HUgn5980
ECgene: REV3L	Kegg: 5980	H-InvDB: REV3L

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for REV3L	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for REV3L	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/rev3l/

Intellectual Property for REV3L gene
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Patent Information for REV3L gene:
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GeneCards and IP:
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REV3L Gene

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

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REV3L Gene

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

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