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Aliases for REV3L Gene

Aliases for REV3L Gene

  • REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit 2 3
  • POLZ 3 4 6
  • REV3 3 4 6
  • EC 4 63
  • REV3 (Yeast Homolog)-Like, Catalytic Subunit Of DNA Polymerase Zeta 2
  • REV3-Like, Catalytic Subunit Of DNA Polymerase Zeta (Yeast) 2
  • Rev-3, Yeast, Homolog-Like (Polymerase, DNA, Zeta) 3
  • DNA Polymerase Zeta Catalytic Subunit 3
  • Protein Reversionless 3-Like 4
  • Polymerase 2
  • REV3-Like 4
  • EC 2.7.7 63
  • HREV3 4
  • Zeta 2
  • DNA 2

External Ids for REV3L Gene

Previous GeneCards Identifiers for REV3L Gene

  • GC06M111455
  • GC06M111643
  • GC06M111665
  • GC06M111726
  • GC06M109191

Summaries for REV3L Gene

GeneCards Summary for REV3L Gene

REV3L (REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Metabolism and DNA Repair. GO annotations related to this gene include nucleotide binding and DNA-directed DNA polymerase activity. An important paralog of this gene is KIAA2022.

UniProtKB/Swiss-Prot for REV3L Gene

  • Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis

Gene Wiki entry for REV3L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REV3L Gene

Genomics for REV3L Gene

Regulatory Elements for REV3L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for REV3L Gene

111,299,028 bp from pter
111,483,715 bp from pter
184,688 bases
Minus strand

Genomic View for REV3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REV3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REV3L Gene

Proteins for REV3L Gene

  • Protein details for REV3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA polymerase zeta catalytic subunit
    Protein Accession:
    Secondary Accessions:
    • O43214
    • Q5TC33

    Protein attributes for REV3L Gene

    3130 amino acids
    Molecular mass:
    352776 Da
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.;
    Quaternary structure:
    • Interacts with MAD2L2.

    Three dimensional structures from OCA and Proteopedia for REV3L Gene

    Alternative splice isoforms for REV3L Gene


neXtProt entry for REV3L Gene

Proteomics data for REV3L Gene at MOPED

Selected DME Specific Peptides for REV3L Gene

Post-translational modifications for REV3L Gene

  • Ubiquitination at Lys2508
  • Modification sites at PhosphoSitePlus

Domains for REV3L Gene

Gene Families for REV3L Gene

  • POL :DNA polymerases

Graphical View of Domain Structure for InterPro Entry



  • O60673
  • Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis
  • The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
  • Belongs to the DNA polymerase type-B family.
  • Contains 1 CysA-type zinc finger.
genes like me logo Genes that share domains with REV3L: view

Function for REV3L Gene

Molecular function for REV3L Gene

GENATLAS Biochemistry: DNA polymerase,zeta,>10kDa,catalytic subunit,S cerevisiae REV3 homolog,involved in reduction of DNA damage,tissue-specific
UniProtKB/Swiss-Prot CatalyticActivity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
UniProtKB/Swiss-Prot Function: Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis

Enzyme Numbers (IUBMB) for REV3L Gene

Gene Ontology (GO) - Molecular Function for REV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005515 protein binding IPI 22828282
genes like me logo Genes that share ontologies with REV3L: view
genes like me logo Genes that share phenotypes with REV3L: view

Animal Models for REV3L Gene

MGI Knock Outs for REV3L:

Animal Model Products

miRNA for REV3L Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REV3L

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for REV3L Gene

Localization for REV3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for REV3L Gene

Subcellular locations from

Jensen Localization Image for REV3L Gene COMPARTMENTS Subcellular localization image for REV3L gene
Compartment Confidence
nucleus 3
chloroplast 2
cytosol 2
mitochondrion 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome --
GO:0005730 nucleolus IEA --
GO:0016035 zeta DNA polymerase complex IDA 20164194
genes like me logo Genes that share ontologies with REV3L: view

Pathways for REV3L Gene

genes like me logo Genes that share pathways with REV3L: view

Gene Ontology (GO) - Biological Process for REV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006261 DNA-dependent DNA replication TAS 9618506
GO:0006281 DNA repair TAS --
GO:0019985 translesion synthesis TAS --
GO:0042276 error-prone translesion synthesis TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REV3L: view

Compounds for REV3L Gene

(6) HMDB Compounds for REV3L Gene

Compound Synonyms Cas Number PubMed IDs
  • 2'-Deoxy-5'-ATP
  • 2'-deoxycytidine-5'-triphosphate
  • 2'-Deoxyguanosine 5'-triphosphate
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion

(2) Novoseek inferred chemical compound relationships for REV3L Gene

Compound -log(P) Hits PubMed IDs
cytidine 36.4 1
cisplatin 19.5 10
genes like me logo Genes that share compounds with REV3L: view

Transcripts for REV3L Gene

Unigene Clusters for REV3L Gene

REV3-like, polymerase (DNA directed), zeta, catalytic subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REV3L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for REV3L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REV3L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP2: - - - -
SP3: - -
SP5: - -
SP10: -

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35
SP1: -
SP3: -
SP4: -
SP6: -
SP7: -
SP8: -
SP9: -

Relevant External Links for REV3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REV3L Gene

mRNA expression in normal human tissues for REV3L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for REV3L Gene

SOURCE GeneReport for Unigene cluster for REV3L Gene Hs.232021

mRNA Expression by UniProt/SwissProt for REV3L Gene

Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with REV3L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for REV3L Gene

Orthologs for REV3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for REV3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REV3L 35
  • 99.74 (n)
  • 99.62 (a)
REV3L 36
  • 100 (a)
(Bos Taurus)
Mammalia REV3L 35
  • 92.26 (n)
  • 91.11 (a)
REV3L 36
  • 91 (a)
(Canis familiaris)
Mammalia REV3L 35
  • 93 (n)
  • 92.62 (a)
REV3L 36
  • 92 (a)
(Mus musculus)
Mammalia Rev3l 35
  • 87.48 (n)
  • 87.1 (a)
Rev3l 16
Rev3l 36
  • 87 (a)
(Monodelphis domestica)
Mammalia REV3L 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia REV3L 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Rev3l 35
  • 85.81 (n)
  • 85.41 (a)
(Gallus gallus)
Aves REV3L 35
  • 75.69 (n)
  • 73.46 (a)
REV3L 36
  • 71 (a)
(Anolis carolinensis)
Reptilia REV3L 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rev3l 35
  • 65.03 (n)
  • 60.05 (a)
(Danio rerio)
Actinopterygii -- 35
rev3l 35
  • 59.69 (n)
  • 57.35 (a)
rev3l 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta mus205 36
  • 32 (a)
mus205 37
  • 52 (a)
(Caenorhabditis elegans)
Secernentea Y37B11A.2 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REV3 36
  • 29 (a)
REV3 38
REV3 38
(Oryza sativa)
Liliopsida Os.33702 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for REV3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REV3L Gene

Gene Tree for REV3L (if available)
Gene Tree for REV3L (if available)

Paralogs for REV3L Gene

Paralogs for REV3L Gene

genes like me logo Genes that share paralogs with REV3L: view

Variants for REV3L Gene

Sequence variations from dbSNP and Humsavar for REV3L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs25639 -- 111,298,747(+) ATTAA(-/TAAT)TAATT downstream-variant-500B
rs56827 -- 111,302,000(-) AGAGC(A/C/G/T)TATTT intron-variant
rs110732 -- 111,358,666(-) TTGTC(A/C)TAGAT intron-variant
rs118202 -- 111,337,168(-) ttata(A/C)tattt intron-variant
rs118203 -- 111,337,017(-) GATTT(A/C)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REV3L Gene

Variant ID Type Subtype PubMed ID
nsv886539 CNV Gain 21882294
nsv886541 CNV Loss 21882294
nsv886542 CNV Loss 21882294
esv2732576 CNV Deletion 23290073
nsv5442 CNV Insertion 18451855
nsv349315 CNV Loss 16902084
esv1005692 CNV Deletion 20482838

Relevant External Links for REV3L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REV3L Gene

Disorders for REV3L Gene

(3) Novoseek inferred disease relationships for REV3L Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 20.8 2
tumors 0 3
cancer 0 1

Relevant External Links for REV3L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with REV3L: view

No data available for UniProtKB/Swiss-Prot for REV3L Gene

Publications for REV3L Gene

  1. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. (PMID: 9618506) Gibbs P.E.M. … Lawrence C.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Alternative splicing, genomic structure, and fine chromosome localization of REV3L. (PMID: 9925914) Morelli C. … Croce C.M. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  3. A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans. (PMID: 10102035) Lin W. … Wang Z. (Mutat. Res. 1999) 3 4 23
  4. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. (PMID: 10660610) Murakumo Y. … Fishel R. (J. Biol. Chem. 2000) 3 4 23
  5. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. (PMID: 20164194) Hara K. … Sato M. (J. Biol. Chem. 2010) 3 4 23

Products for REV3L Gene

Sources for REV3L Gene

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