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REV3L Gene

protein-coding   GIFtS: 64
GCID: GC06M111665

REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit

(Previous names: REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit1 2     zeta1
POLZ2 3 5     DNA Polymerase Zeta Catalytic Subunit2
REV32 3 5     Rev-3, Yeast, Homolog-Like (Polymerase, DNA, Zeta)2
EC 2.7.7.73 8     REV3-like3
DNA1     hREV33
polymerase1     Protein Reversionless 3-Like3
REV3 (Yeast Homolog)-Like, Catalytic Subunit Of DNA Polymerase Zeta1     EC 2.7.78
REV3-Like, Catalytic Subunit Of DNA Polymerase Zeta (Yeast)1     

External Ids:    HGNC: 99681   Entrez Gene: 59802   Ensembl: ENSG000000094137   OMIM: 6027765   UniProtKB: O606733   

Export aliases for REV3L gene to outside databases

Previous GC identifers: GC06M111455 GC06M111643 GC06M111726 GC06M109191


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for REV3L Gene:
REV3L (REV3-like, polymerase (DNA directed), zeta, catalytic subunit) is a protein-coding gene. GO annotations related to this gene include DNA-directed DNA polymerase activity and nucleotide binding. An important paralog of this gene is KIAA2022.

UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673
Function: Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis

Gene Wiki entry for REV3L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the REV3L gene promoter:
         GR   FOXO3   POU6F1 (c2)   FOXO3b   Meis-1b   FOXO3a   GR-alpha   Meis-1a   Ik-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): REV3L promoter sequence
   Search Chromatin IP Primers for REV3L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REV3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22

REV3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REV3L gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M111665:  view genomic region     (about GC identifiers)

Start:
111,620,234 bp from pter      End:
111,804,918 bp from pter
Size:
184,685 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673 (See protein sequence)
Recommended Name: DNA polymerase zeta catalytic subunit  
Size: 3130 amino acids; 352776 Da
Cofactor: Binds 1 4Fe-4S cluster (By similarity)
Subunit: Interacts with MAD2L2
6 PDB 3D structures from and Proteopedia for REV3L:
3ABD (3D)        3ABE (3D)        3VU7 (3D)        4EXT (3D)        4GK0 (3D)        4GK5 (3D)    
Secondary accessions: O43214 Q5TC33
Alternative splicing: 2 isoforms:  O60673-1   O60673-2   

Explore the universe of human proteins at neXtProt for REV3L: NX_O60673

Explore proteomics data for REV3L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys2508
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for REV3L (O60673)
     ARVVYGD  KGIETVRRD 


    See REV3L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273360.1  NP_001273361.1  NP_002903.3  

    ENSEMBL proteins: 
     ENSP00000391605   ENSP00000357792   ENSP00000357795   ENSP00000393184   ENSP00000400600  
     ENSP00000351697   ENSP00000402003  

    REV3L Human Recombinant Protein Products:

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    Novus Biologicals REV3L Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for REV3L 

     
    antibodies-online proteins for REV3L (2 products) 

     
    Search antibodies-online for peptides for REV3L

    REV3L Antibody Products:

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    LSBio Antibodies in human, mouse, rat for REV3L
    antibodies-online antibodies for REV3L (8 products) 

    REV3L Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for REV3L 
    Search antibodies-online for kits for REV3L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POL: DNA polymerases

    Selected InterPro protein domains (see all 7):
     IPR025687 Znf-C4pol
     IPR006172 DNA-dir_DNA_pol_B
     IPR006133 DNA-dir_DNA_pol_B_exonuc
     IPR006134 DNA-dir_DNA_pol_B_multi_dom
     IPR023211 DNA_pol_palm_dom

    Graphical View of Domain Structure for InterPro Entry O60673

    ProtoNet protein and cluster: O60673

    1 Blocks protein domain: IPB006134 DNA polymerase B domain

    UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673
    Domain: Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its
    N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA
    synthesis
    Domain: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes (By
    similarity)
    Similarity: Belongs to the DNA polymerase type-B family
    Similarity: Contains 1 CysA-type zinc finger


    Find genes that share domains with REV3L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOLZ_HUMAN, O60673
    Function: Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for REV3L:
    DNA polymerase,zeta,>10kDa,catalytic subunit,S cerevisiae REV3 homolog,involved in reduction of DNA
    damage,tissue-specific

         Enzyme Numbers (IUBMB): EC 2.7.7.71 2 EC 2.7.72

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003887DNA-directed DNA polymerase activity IBA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with REV3L           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for REV3L:
     Decreased viability with cispl 

         11 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Rev3l):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     tumorigenesis 

    Find genes that share phenotypes with REV3L           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for REV3L: Rev3ltm1Esp Rev3ltm1Ndew Rev3ltm1Kaji Rev3ltm1Msn Rev3ltm1.1Rsky

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REV3L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REV3L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REV3L

    miRNA
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    miRTarBase miRNAs that target REV3L:
    hsa-mir-21-5p (MIRT030718), hsa-mir-93-5p (MIRT028057), hsa-mir-340-5p (MIRT019556), hsa-mir-183-5p (MIRT025031)

    Block miRNA regulation of human, mouse, rat REV3L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate REV3L (see all 63):
    hsa-miR-124* hsa-miR-4317 hsa-miR-548j hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-548k hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidREV3L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for REV3L
    Predesigned siRNA for gene silencing in human, mouse, rat REV3L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REV3L

    Clone
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    GenScript: all cDNA clones in your preferred vector: REV3L (NM_002912)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REV3L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REV3L
    Addgene plasmids for REV3L 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REV3L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPOLZ_HUMAN, O60673: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    chloroplast2
    cytosol2
    mitochondrion2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005694chromosome IBA--
    GO:0016035zeta DNA polymerase complex IDA--

    Find genes that share ontologies with REV3L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for REV3L About    
    See pathways by source

    SuperPathContained pathways About
    1DNA Damage Bypass
    DNA Damage Bypass
    Translesion synthesis by Pol zeta0.00
    Translesion synthesis by DNA polymerases bypassing lesion on DNA template0.00
    2DNA Repair
    DNA Repair0.45
    3Metabolism
    Metabolic pathways0.38
    4Fanconi anemia pathway (KEGG)
    Fanconi anemia pathway


    Find genes that share SuperPaths with REV3L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for REV3L):
        Metabolic pathways
    Fanconi anemia pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REV3L
    Interactions:

        GeneGlobe Interaction Network for REV3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REV3L (O606731, 2, 3 ENSP000003516974) via UniProtKB, MINT, STRING, and/or I2D (see all 246)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L2Q9UI951, 2, 3, ENSP000002353104EBI-2871302,EBI-77889 MINT-8385495 MINT-8385803 MINT-8385849 MINT-8385833 MINT-8385442 I2D: score=3 STRING: ENSP00000235310
    REV1Q9UBZ92, ENSP000002584284MINT-8385495 MINT-8385803 MINT-8385833 MINT-8385442 STRING: ENSP00000258428
    CHEK2O960173, ENSP000003720234I2D: score=1 STRING: ENSP00000372023
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006260DNA replication ----
    GO:0006261DNA-dependent DNA replication TAS9618506
    GO:0006281DNA repair ----
    GO:0006297NOT nucleotide-excision repair, DNA gap filling IBA--

    Find genes that share ontologies with REV3L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REV3L (DPOLZ)

    6 HMDB Compounds for REV3L    About this table
    CompoundSynonyms CAS #PubMed Ids
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--

    2 Novoseek inferred chemical compound relationships for REV3L gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 36.4 1 15198729 (1)
    cisplatin 19.5 19 15520212 (5), 16428501 (5)



    Find genes that share compounds with REV3L           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REV3L gene (3 alternative transcripts): 
    NM_001286431.1  NM_001286432.1  NM_002912.4  

    Unigene Cluster for REV3L:

    REV3-like, polymerase (DNA directed), zeta, catalytic subunit
    Hs.232021  [show with all ESTs]
    Unigene Representative Sequence: AF078695
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462119(uc003puw.4) ENST00000434009 ENST00000368802 ENST00000368805(uc003pva.1)
    ENST00000422377(uc003puy.4 uc003pux.4 uc003puz.4) ENST00000413831
    ENST00000492520 ENST00000467500 ENST00000470871 ENST00000460981 ENST00000494858
    ENST00000358835 ENST00000435970
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate REV3L (see all 63):
    hsa-miR-124* hsa-miR-4317 hsa-miR-548j hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-548k hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidREV3L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat REV3L
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REV3L (NM_002912)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REV3L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REV3L
    Addgene plasmids for REV3L 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat REV3L
      QuantiFast Probe-based Assays in human, mouse, rat REV3L

    Additional mRNA sequence: 

    AB209256.1 AF004713.1 AF035537.1 AF058701.1 AF071798.1 AF078695.1 AF157476.1 AF179428.1 
    AF179429.1 AF303220.1 AK310949.1 AL096744.1 BC035823.1 BC038986.1 

    22 DOTS entries:

    DT.95169408  DT.91839106  DT.100751947  DT.95169406  DT.100751948  DT.107807  DT.416663  DT.100751949 
    DT.121340284  DT.40122352  DT.86836533  DT.95245790  DT.92023460  DT.97855536  DT.100740709  DT.65287234 
    DT.91882815  DT.91927451  DT.92426155  DT.97780664  DT.97810487  DT.99948008 

    Selected AceView cDNA sequences (see all 159):

    BG403781 AA308432 AF071798 BG568719 AF179428 R34909 AF157476 AU280275 
    CK904633 AW958271 AF035537 BM068795 BM461441 AA334113 AA448067 BM478597 
    BM806800 H38497 AA694048 CD674579 BC035823 BM854960 AA435818 BM459612 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for REV3L (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                                                                            
    SP2:                    -     -     -     -                                                                                                                     
    SP3:                                                                                                                                                  -     -   
    SP4:                                                                                                                                                            
    SP5:                                -     -                                                                                                                     

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35
    SP1:        -                                                                                                                                       
    SP2:                                                                                                                                                
    SP3:        -                                                                                                                                       
    SP4:                                                                                                                    -                           
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for REV3L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REV3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACTTCCC
    REV3L Expression
    About this image

    REV3L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REV3L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.232021

    UniProtKB/Swiss-Prot: DPOLZ_HUMAN, O60673
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for REV3L
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for REV3L gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rev3l1 , 5 REV3-like, catalytic subunit of DNA polymerase zeta more1, 5 87.48(n)1
    87.1(a)1
      10 (21.04 cM)5
    197141  NM_011264.31  NP_035394.21 
     397321185 
    chicken
    (Gallus gallus)
    Aves REV3L1 REV3-like, polymerase (DNA directed), zeta, catalytic more 75.69(n)
    73.46(a)
      428622  XM_426179.4  XP_426179.4 
    lizard
    (Anolis carolinensis)
    Reptilia REV3L6
    REV3-like, polymerase (DNA directed), zeta, cataly...
    66(a)
    1 ↔ 1
    1(192207952-192276827)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480509342   -- 78.67(n)    48050934 
    zebrafish
    (Danio rerio)
    Actinopterygii 570447792   -- 73.35(n)   386961  57044779 
    fruit fly
    (Drosophila melanogaster)
    Insecta mus2053 DNA replication zeta DNA polymerase 52(a)   2 43E17   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REV3(YPL167C)4 Catalytic subunit of DNA polymerase zeta, involved more   --   16(237107-232593) 855936  NP_015158.1 
    rice
    (Oryza sativa)
    Liliopsida Os.337022 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.27(n)    NM_186110.1 


    ENSEMBL Gene Tree for REV3L (if available)
    TreeFam Gene Tree for REV3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REV3L gene
    KIAA20222  

    Find genes that share paralogs with REV3L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REV3L (see all 3439)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs175116461,2
    C,F--111619826(-) CACCTG/AGTTAT 1 -- int12Minor allele frequency- A:0.03NS EA 240
    rs175403601,2
    C--111619852(-) AGTTAGTTA/-  
            
    TTATT
    1 -- int11Minor allele frequency- -:0.01NS 118
    rs1435365611,2
    --111619893(+) AAAAAC/TTGGCA 1 -- int10--------
    rs665371601,2
    C--111619943(+) TTAAT-/TAAT  
            
    AATTA
    1 -- int10--------
    rs256391,2
    C,F--111619950(+) ATTAA-/TAAT  
            
    TAATT
    1 -- int11Minor allele frequency- TAAT:0.22NS 172
    rs355708341,2
    C--111619952(+) AATTAATTA/-  
            
    TATCA
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs175403461,2
    C,F--111619990(-) TTGTT-/TGTT  
            
    AGTAG
    1 -- int11Minor allele frequency- TGTT:0.38NS 144
    rs1483537611,2
    C--111619990(+) CTACT-/AACA  
            
    AACAA
    1 -- int10--------
    rs568472901,2
    C--111619991(+) AACAA-/ACAA  
            
    GTACA
    1 -- int11Minor allele frequency- ACAA:0.00NA 2
    rs2409591,2
    C,F,A,H--111620013(-) AGAGAT/GTTTTA 1 -- int112Minor allele frequency- G:0.29MN NS EA NA CSA WA 1138

    HapMap Linkage Disequilibrium report for REV3L (111620234 - 111804918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for REV3L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732576CNV Deletion23290073
    esv1005692CNV Deletion20482838
    nsv5442CNV Insertion18451855
    nsv349315CNV Loss16902084
    nsv886542CNV Loss21882294
    nsv886541CNV Loss21882294
    nsv886539CNV Gain21882294

    Human Gene Mutation Database (HGMD): REV3L
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REV3L
    DNA2.0 Custom Variant and Variant Library Synthesis for REV3L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602776    OMIM disorders: --

    9 diseases from the University of Copenhagen DISEASES database for REV3L:
    Hepatitis B     Herpes simplex     Hepatitis     Xeroderma pigmentosum
    Cancer     Acquired immunodeficiency syndrome     Retinitis     Vaccinia
    Herpes zoster

    Find genes that share disorders with REV3L           About GenesLikeMe

    3 Novoseek inferred disease relationships for REV3L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 20.8 3 16428501 (2)
    tumors 0 5 10660610 (1), 9635887 (1), 11115544 (1)
    cancer 0 1 16428501 (1)

    Genetic Association Database (GAD): REV3L
    Human Genome Epidemiology (HuGE) Navigator: REV3L (7 documents)

    Export disorders for REV3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REV3L gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with REV3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. (PubMed id 9618506)1, 2, 3, 9 Gibbs P.E.M.... Lawrence C.W. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Alternative splicing, genomic structure, and fine chromosome localization of REV3L. (PubMed id 9925914)1, 2, 3, 9 Morelli C.... Croce C.M. (Cytogenet. Cell Genet. 1998)
    3. A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans. (PubMed id 10102035)1, 2, 9 Lin W.... Wang Z. (Mutat. Res. 1999)
    4. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. (PubMed id 20164194)1, 2, 9 Hara K.... Sato M. (J. Biol. Chem. 2010)
    5. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. (PubMed id 10660610)1, 2, 9 Murakumo Y....Fishel R. (J. Biol. Chem. 2000)
    6. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1, 4 Kettunen J....Ripatti S. (Nat. Genet. 2012)
    7. Human metabolic individuality in biomedical and pharmaceutical research. (PubMed id 21886157)1, 4 Suhre K....Gieger C. (Nature 2011)
    8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    9. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. (PubMed id 20953190)1, 4  ....Trembath R.C. (Nat. Genet. 2010)
    10. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5980 HGNC: 9968 AceView: REV3L Ensembl:ENSG00000009413 euGenes: HUgn5980
    ECgene: REV3L Kegg: 5980 H-InvDB: REV3L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REV3L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for REV3L Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rev3l/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REV3L gene:
    Search GeneIP for patents involving REV3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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