Free for academic non-profit institutions. Other users need a Commercial license

Aliases for REV3L Gene

Aliases for REV3L Gene

  • REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit 2 3 5
  • REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit 2 3
  • EC 2.7.7.7 4 63
  • POLZ 3 4
  • REV3 3 4
  • REV3 (Yeast Homolog)-Like, Catalytic Subunit Of DNA Polymerase Zeta 2
  • REV3-Like, Catalytic Subunit Of DNA Polymerase Zeta (Yeast) 2
  • Rev-3, Yeast, Homolog-Like (Polymerase, DNA, Zeta) 3
  • Protein Reversionless 3-Like 4
  • Polymerase 2
  • REV3-Like 4
  • EC 2.7.7 63
  • HREV3 4
  • Zeta 2
  • DNA 2

External Ids for REV3L Gene

Previous GeneCards Identifiers for REV3L Gene

  • GC06M111455
  • GC06M111643
  • GC06M111665
  • GC06M111726
  • GC06M109191

Summaries for REV3L Gene

GeneCards Summary for REV3L Gene

REV3L (REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit) is a Protein Coding gene. Diseases associated with REV3L include Moebius Syndrome and Splenic Infarction. Among its related pathways are Fanconi anemia pathway and DNA Double-Strand Break Repair. GO annotations related to this gene include nucleic acid binding and 4 iron, 4 sulfur cluster binding. An important paralog of this gene is KIAA2022.

UniProtKB/Swiss-Prot for REV3L Gene

  • Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.

Gene Wiki entry for REV3L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REV3L Gene

Genomics for REV3L Gene

Regulatory Elements for REV3L Gene

Enhancers for REV3L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around REV3L on UCSC Golden Path with GeneCards custom track

Promoters for REV3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around REV3L on UCSC Golden Path with GeneCards custom track

Genomic Location for REV3L Gene

Chromosome:
6
Start:
111,299,028 bp from pter
End:
111,483,715 bp from pter
Size:
184,688 bases
Orientation:
Minus strand

Genomic View for REV3L Gene

Genes around REV3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REV3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REV3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REV3L Gene

Proteins for REV3L Gene

  • Protein details for REV3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60673-DPOLZ_HUMAN
    Recommended name:
    DNA polymerase zeta catalytic subunit
    Protein Accession:
    O60673
    Secondary Accessions:
    • O43214
    • Q5TC33

    Protein attributes for REV3L Gene

    Size:
    3130 amino acids
    Molecular mass:
    352776 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Interacts with MAD2L2.

    Three dimensional structures from OCA and Proteopedia for REV3L Gene

    Alternative splice isoforms for REV3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REV3L Gene

Proteomics data for REV3L Gene at MOPED

Selected DME Specific Peptides for REV3L Gene

Post-translational modifications for REV3L Gene

  • Ubiquitination at Lys 2508
  • Modification sites at PhosphoSitePlus

Domains & Families for REV3L Gene

Gene Families for REV3L Gene

Graphical View of Domain Structure for InterPro Entry

O60673

UniProtKB/Swiss-Prot:

DPOLZ_HUMAN :
  • Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.
  • Belongs to the DNA polymerase type-B family.
  • Contains 1 CysA-type zinc finger.
Domain:
  • Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.
  • The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
Family:
  • Belongs to the DNA polymerase type-B family.
Similarity:
  • Contains 1 CysA-type zinc finger.
genes like me logo Genes that share domains with REV3L: view

Function for REV3L Gene

Molecular function for REV3L Gene

GENATLAS Biochemistry:
DNA polymerase,zeta,>10kDa,catalytic subunit,S cerevisiae REV3 homolog,involved in reduction of DNA damage,tissue-specific
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
UniProtKB/Swiss-Prot Function:
Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.

Enzyme Numbers (IUBMB) for REV3L Gene

Gene Ontology (GO) - Molecular Function for REV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 22828282
GO:0008408 3-5 exonuclease activity IEA --
genes like me logo Genes that share ontologies with REV3L: view
genes like me logo Genes that share phenotypes with REV3L: view

Human Phenotype Ontology for REV3L Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for REV3L Gene

MGI Knock Outs for REV3L:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for REV3L Gene

Localization for REV3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for REV3L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REV3L Gene COMPARTMENTS Subcellular localization image for REV3L gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for REV3L Gene

Pathways & Interactions for REV3L Gene

genes like me logo Genes that share pathways with REV3L: view

Pathways by source for REV3L Gene

Gene Ontology (GO) - Biological Process for REV3L Gene

None

No data available for SIGNOR curated interactions for REV3L Gene

Drugs & Compounds for REV3L Gene

(53) Drugs for REV3L Gene - From: PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Biomarker, inhibitor Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
Mitomycin Approved Pharma binder Inhibits DNA synthesis,antibiotic and antitumor agent 0
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1239
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
Altretamine Approved Pharma 58

(2) Additional Compounds for REV3L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with REV3L: view

Transcripts for REV3L Gene

Unigene Clusters for REV3L Gene

REV3-like, polymerase (DNA directed), zeta, catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REV3L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP1:
SP2: - - - -
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6: -
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for REV3L Gene

GeneLoc Exon Structure for
REV3L
ECgene alternative splicing isoforms for
REV3L

Expression for REV3L Gene

mRNA expression in normal human tissues for REV3L Gene

Protein differential expression in normal tissues from HIPED for REV3L Gene

This gene is overexpressed in Breast (25.6), Bone marrow mesenchymal stem cell (16.5), and Plasma (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REV3L Gene



SOURCE GeneReport for Unigene cluster for REV3L Gene Hs.232021

mRNA Expression by UniProt/SwissProt for REV3L Gene

O60673-DPOLZ_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with REV3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for REV3L Gene

Orthologs for REV3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for REV3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia REV3L 35
  • 92.26 (n)
  • 91.11 (a)
REV3L 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REV3L 35
  • 93 (n)
  • 92.62 (a)
REV3L 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rev3l 35
  • 87.48 (n)
  • 87.1 (a)
Rev3l 16
Rev3l 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia REV3L 35
  • 99.74 (n)
  • 99.62 (a)
REV3L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rev3l 35
  • 85.81 (n)
  • 85.41 (a)
oppossum
(Monodelphis domestica)
Mammalia REV3L 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REV3L 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves REV3L 35
  • 75.69 (n)
  • 73.46 (a)
REV3L 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia REV3L 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rev3l 35
  • 65.03 (n)
  • 60.05 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
rev3l 35
  • 59.69 (n)
  • 57.35 (a)
rev3l 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mus205 37
  • 52 (a)
mus205 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37B11A.2 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REV3 36
  • 29 (a)
OneToMany
REV3 38
REV3 38
rice
(Oryza sativa)
Liliopsida Os.33702 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for REV3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REV3L Gene

ENSEMBL:
Gene Tree for REV3L (if available)
TreeFam:
Gene Tree for REV3L (if available)

Paralogs for REV3L Gene

Paralogs for REV3L Gene

genes like me logo Genes that share paralogs with REV3L: view

Variants for REV3L Gene

Sequence variations from dbSNP and Humsavar for REV3L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1053911 - 111,390,150(-) CCACA(C/G)AGTAC nc-transcript-variant, reference, missense
VAR_008517 -
rs1053913 - 111,373,737(-) AGCAG(A/G)AAGCA nc-transcript-variant, reference, missense
VAR_008519 -
VAR_016147 -

Structural Variations from Database of Genomic Variants (DGV) for REV3L Gene

Variant ID Type Subtype PubMed ID
nsv886539 CNV Gain 21882294
nsv886541 CNV Loss 21882294
nsv886542 CNV Loss 21882294
esv2732576 CNV Deletion 23290073
nsv5442 CNV Insertion 18451855
nsv349315 CNV Loss 16902084
esv1005692 CNV Deletion 20482838

Variation tolerance for REV3L Gene

Residual Variation Intolerance Score: 1.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.62; 82.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REV3L Gene

Human Gene Mutation Database (HGMD)
REV3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REV3L Gene

Disorders for REV3L Gene

MalaCards: The human disease database

(3) MalaCards diseases for REV3L Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
moebius syndrome
  • mobius syndrome
splenic infarction
  • splenic infarct
pharyngitis
  • acute sore throat
- elite association - COSMIC cancer census association via MalaCards
Search REV3L in MalaCards View complete list of genes associated with diseases

Relevant External Links for REV3L

Genetic Association Database (GAD)
REV3L
Human Genome Epidemiology (HuGE) Navigator
REV3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REV3L
genes like me logo Genes that share disorders with REV3L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REV3L Gene

Publications for REV3L Gene

  1. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. (PMID: 9618506) Gibbs P.E.M. … Lawrence C.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Alternative splicing, genomic structure, and fine chromosome localization of REV3L. (PMID: 9925914) Morelli C. … Croce C.M. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. (PMID: 20164194) Hara K. … Sato M. (J. Biol. Chem. 2010) 3 23
  4. DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. (PMID: 19564618) Ziv O. … Livneh Z. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  5. Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment. (PMID: 20054135) Hara K. … Hashimoto H. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009) 3 23

Products for REV3L Gene

Sources for REV3L Gene

Content