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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REV1 Gene

protein-coding   GIFtS: 58
GCID: GC02M100016

REV1, Polymerase (DNA Directed)

(Previous names: REV1 (yeast homolog)- like, REV1-like (yeast), REV1 homolog...)
(Previous symbol: REV1L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
REV1, Polymerase (DNA Directed)1 2     REV1 Homolog (S. Cerevisiae)1
REV1L1 2 3     REV1-Like (Yeast)1
Alpha Integrin-Binding Protein 802 3     DNA Repair Protein REV12
Rev1-Like Terminal Deoxycytidyl Transferase2 3     REV1 Homolog2
AIBP802 3     REV1- Like2
REV1 (Yeast Homolog)- Like1     EC 2.7.7.-3

External Ids:    HGNC: 140601   Entrez Gene: 514552   Ensembl: ENSG000001359457   OMIM: 6061345   UniProtKB: Q9UBZ93   

Export aliases for REV1 gene to outside databases

Previous GC identifers: GC02M099383 GC02M093782


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REV1 Gene:
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins
contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human
Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of
damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.
(provided by RefSeq, Jul 2008)

GeneCards Summary for REV1 Gene: 
REV1 (REV1, polymerase (DNA directed)) is a protein-coding gene. Diseases associated with REV1 include denture stomatitis, and brucellosis, and among its related super-pathways are Translesion synthesis by Pol zeta and Nucleotide Excision Repair. GO annotations related to this gene include magnesium ion binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLK.

UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9
Function: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a
DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the
insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and
chemical agents

Gene Wiki entry for REV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REV1 gene promoter:
         ER-alpha   C/EBPbeta   Pbx1a   FOXF2   C/EBPalpha   Arnt   HOXA5   IRF-7A   Cart-1   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for REV1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1-q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.1-q11.2

REV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REV1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M100016:  view genomic region     (about GC identifiers)

Start:
100,016,938 bp from pter      End:
100,106,497 bp from pter
Size:
89,560 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9 (See protein sequence)
Recommended Name: DNA repair protein REV1  
Size: 1251 amino acids; 138248 Da
Subunit: Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction
with MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK.
May bind ITGA3. Interacts with FAAP20/C1orf86
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAK43708.1; Type=Erroneous initiation;
6/9 PDB 3D structures from and Proteopedia for REV1 (see all 9):
2EBW (3D)        2LSI (3D)        2LSK (3D)        2LSY (3D)        3GQC (3D)        3VU7 (3D)    
Secondary accessions: O95941 Q53SI7 Q9C0J4 Q9NUP2
Alternative splicing: 3 isoforms:  Q9UBZ9-1   Q9UBZ9-2   Q9UBZ9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for REV1: NX_Q9UBZ9

Explore proteomics data for REV1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBZ9

  • REV1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REV1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001032961.1  NP_057400.1  

    ENSEMBL proteins: 
     ENSP00000377091   ENSP00000258428   ENSP00000416274   ENSP00000404213   ENSP00000414875  
    Reactome Protein details: Q9UBZ9
    Human Recombinant Protein Products for REV1: 
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    Novus Biologicals REV1 Protein
    Novus Biologicals REV1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REV1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    REV1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for REV1 
    Cloud-Clone Corp. CLIAs for REV1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POL: DNA polymerases

    5 InterPro protein domains:
     IPR001126 DNA_repair_prot_UmuC-like
     IPR017963 DNA_repair_prot_UmuC-like_N
     IPR017961 DNA_pol_Y-fam_little_finger
     IPR012112 REV1
     IPR001357 BRCT_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBZ9

    ProtoNet protein and cluster: Q9UBZ9

    1 Blocks protein domain: IPB001126 UMUC-like DNA-repair protein

    UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9
    Domain: The C-terminal domain is necessary for protein interactions
    Similarity: Belongs to the DNA polymerase type-Y family
    Similarity: Contains 1 BRCT domain
    Similarity: Contains 1 umuC domain


    REV1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REV1_HUMAN, Q9UBZ9
    Function: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a
    DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the
    insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and
    chemical agents

         Enzyme Number (IUBMB): EC 2.7.7.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003684damaged DNA binding IEA--
    GO:0003887DNA-directed DNA polymerase activity TAS--
    GO:0005515protein binding IPI11485998
    GO:0016779nucleotidyltransferase activity ----
         
    REV1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for REV1:
     Decreased viability with cispl  Increased cell death in breast  Synthetic lethal with cisplati  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rev1):
     cellular  growth/size  hematopoietic system  immune system  mortality/aging 
     normal 

    REV1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for REV1: Rev1tm2Ndew Rev1tm1Ndew

       inGenious Targeting Laboratory - Custom generated mouse model solutions for REV1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REV1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REV1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REV1 

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    SwitchGear 3'UTR luciferase reporter plasmidREV1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REV1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for REV1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Translesion synthesis by DNA polymerases bypassing lesion on DNA template
    Translesion synthesis by DNA polymerases bypassing lesion on DNA template 0.50
    DNA Damage Bypass0.50
    2Nucleotide Excision Repair
    DNA Repair0.46
    3Translesion synthesis by HREV1
    Translesion synthesis by HREV1
    4Fanconi anemia pathway
    Fanconi anemia pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for REV1
        DNA Repair
    Translesion synthesis by DNA polymerases bypassing lesion on DNA template
    DNA Damage Bypass
    Translesion synthesis by HREV1


    1         Kegg Pathway  (Kegg details for REV1):
        Fanconi anemia pathway


    REV1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for REV1 (Q9UBZ92, 3 ENSP000002584284) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L2Q9UI952, 3, ENSP000002353104MINT-8385495 MINT-8385803 MINT-8385833 MINT-8385442 I2D: score=4 STRING: ENSP00000235310
    REV3LO606732, ENSP000003516974MINT-8385495 MINT-8385803 MINT-8385833 MINT-8385442 STRING: ENSP00000351697
    POLHQ9Y2532, 3, ENSP000003613104MINT-8385495 MINT-8385863 I2D: score=6 STRING: ENSP00000361310
    FHL2Q141922, 3, ENSP000003229094MINT-17606 MINT-17605 I2D: score=3 STRING: ENSP00000322909
    POLIQ9UNA43, ENSP000002178004I2D: score=5 STRING: ENSP00000217800
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair TAS--
    GO:0009411response to UV IDA11485998
    GO:0042276error-prone translesion synthesis TAS11485998

    REV1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    REV1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REV1

    2 Novoseek inferred chemical compound relationships for REV1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dcmp 73.5 2 11278384 (1), 8977026 (1)
    cisplatin 18.4 7 20028736 (4), 16495473 (1)

    Search CenterWatch for drugs/clinical trials and news about REV1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REV1 gene (2 alternative transcripts): 
    NM_001037872.1  NM_016316.2  

    Unigene Cluster for REV1:

    REV1, polymerase (DNA directed)
    Hs.443077  [show with all ESTs]
    Unigene Representative Sequence: NM_016316
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393445 ENST00000258428(uc002tac.3 uc002tad.3) ENST00000413697
    ENST00000482595 ENST00000465086 ENST00000485487 ENST00000465835 ENST00000438366
    ENST00000472000 ENST00000477121 ENST00000481719 ENST00000450415 ENST00000486117
    ENST00000491752 ENST00000482887 ENST00000473819(uc002tae.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate REV1 (see all 48):
    hsa-miR-124* hsa-miR-3607-3p hsa-miR-3146 hsa-miR-429 hsa-miR-875-5p hsa-miR-139-5p hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidREV1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB047646.1 AF151538.1 AF206019.1 AF357886.1 AJ131720.1 AK002087.1 AK025176.1 AK307719.1 
    BC037734.1 BC130411.1 

    20 DOTS entries:

    DT.453021  DT.86999396  DT.92022708  DT.95165367  DT.120952324  DT.120952483  DT.120952514  DT.92427023 
    DT.211288  DT.95243594  DT.453022  DT.120952371  DT.120952481  DT.40121561  DT.95165368  DT.99994551 
    DT.40119336  DT.95123766  DT.97763025  DT.99975995 

    24/149 AceView cDNA sequences (see all 149):

    CR618059 CA416394 AF206019 AA195405 AF357886 AI657128 AA195457 AI245665 
    AI476068 AI432201 BG288771 BF981993 NM_016316 AJ131720 AA746273 AA699340 
    AU138299 CB851608 AK002087 AK025176 AI452513 AF151538 T08134 AA713663 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for REV1 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18 ^
    SP1:                                                              -                                         -           -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                        -           -     -                                 
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                -                           
    SP5:                                                            


    ECgene alternative splicing isoforms for REV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REV1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAATTG
    REV1 Expression
    About this image


    See REV1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REV1

    SOURCE GeneReport for Unigene cluster: Hs.443077

    UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including REV1: 
              DNA Damage Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for REV1 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rev11 , 5 REV1 homolog (S. cerevisiae)1, 5 85.68(n)1
    84.5(a)1
      1 (16.46 cM)5
    562101  NM_019570.31  NP_062516.21 
     380527875 
    chicken
    (Gallus gallus)
    Aves REV11 REV1 homolog (S. cerevisiae) 78.92(n)
    78.7(a)
      418703  NM_001030811.2  NP_001025982.2 
    lizard
    (Anolis carolinensis)
    Reptilia REV16
    REV1, polymerase (DNA directed)
    70(a)
    1 ↔ 1
    GL343456.1(79152-134386)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.327992 Xenopus laevis transcribed sequence with weak similarity more 82.67(n)    BJ099195.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-57a22.71 si:dkey-57a22.7 57.91(n)
    56.23(a)
      570043  NM_001123300.1  NP_001116772.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rev11 CG12189-PA 50.38(n)
    46.38(a)
      38079  NM_138203.2  NP_612047.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rev-16
    Protein REV-1
    27(a)
    1 ↔ 1
    II(7900647-7904636)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REV1(YOR346W)4 Deoxycytidyl transferase; involved in repair of abasic more   --   15(981828-984785) 854527  NP_014991.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons REV11 DNA repair protein REV1 46.25(n)
    35.4(a)
      834504  NM_123842.4  NP_199288.4 
    rice
    (Oryza sativa)
    Liliopsida Os06g06910001 hypothetical protein 47.48(n)
    38.38(a)
      4341904  NM_001064954.1  NP_001058419.1 


    ENSEMBL Gene Tree for REV1 (if available)
    TreeFam Gene Tree for REV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REV1 gene
    POLK2  POLH2  POLI2  

    REV1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for REV1
    PGOHUM00000237511


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1869 SNPs in REV1 are shown (see all 1869)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893644801,2
    --100017236(+) TAAGAC/TGGTTT 2 -- ut310--------
    rs1818630831,2
    --100017275(+) AGAATC/TCCGGT 2 -- ut310--------
    rs283829801,2
    F--100017352(-) CTACT-/G/GTTT
            
    GTTTA
    4 -- ut315NS 158
    rs1862207251,2
    --100017454(+) CACTGC/TAAAAA 2 -- ut310--------
    rs38385831,2
    C--100017515(-) TGTTA-/ATTA  
            
    TTTTA
    2 -- ut310--------
    rs283829791,2
    C,F--100017518(-) TTGTGTTAA/-  
            
    TTATT
    2 -- ut315Minor allele frequency- -:0.11NS 190
    rs37921531,2
    C,F,H--100017545(-) TTTGTC/TAGTAT 2 -- ut3110Minor allele frequency- T:0.02EA NS 2068
    rs1890266931,2
    C--100017609(+) AAATTA/GTAAAA 2 -- ut310--------
    rs1996871541,2
    --100017685(+) GAGCAG/TCAGGC 2 -- ut310--------
    rs1463775151,2
    C,F--100017755(+) TGGACA/GTTGTC 4 N syn12Minor allele frequency- G:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for REV1 (100016938 - 100106497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for REV1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2052109CNV Deletion18987734
    esv2555492CNV Deletion19546169
    esv2720432CNV Deletion23290073
    esv4405CNV Deletion18987735
    esv2658486CNV Deletion23128226
    nsv821279CNV Deletion20802225
    nsv511799CNV Loss21212237
    nsv829580CNV Loss20364138
    nsv874700CNV Loss21882294
    nsv524466CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606134    OMIM disorders: --

    18 diseases for REV1:    About MalaCards
    denture stomatitis    brucellosis    stomatitis    werner syndrome
    stomach cancer    xeroderma pigmentosum    fanconi's anemia    esophageal adenocarcinoma
    meningioma    anemia    chronic lymphocytic leukemia    pneumonia
    cervicitis    tuberculosis    esophagitis    lung cancer
    adenocarcinoma    leukemia

    2 diseases from the University of Copenhagen DISEASES database for REV1:
    Brucellosis     Xeroderma pigmentosum

    REV1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): REV1
    Human Genome Epidemiology (HuGE) Navigator: REV1 (8 documents)

    Export disorders for REV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REV1 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with REV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human REV1 gene codes for a DNA template-dependent dCMP transferase. (PubMed id 10536157)1, 2, 3, 9 Lin W.... Wang Z. (1999)
    2. Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins. (PubMed id 12529368)1, 2, 9 Masuda Y.... Kamiya K. (2003)
    3. Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain. (PubMed id 11278384)1, 2, 9 Masuda Y.... Kamiya K. (2001)
    4. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. (PubMed id 10760286)1, 2, 9 Gibbs P.E.M.... Maher V.M. (2000)
    5. Crystal structure of human REV7 in complex with a hum an REV3 fragment and structural implication of the interaction between DNA poly merase zeta and REV1. (PubMed id 20164194)1, 2, 9 Hara K....Sato M. (2010)
    6. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. (PubMed id 11485998)1, 2, 9 Murakumo Y.... Takahashi M. (2001)
    7. Regulation of Rev1 by the Fanconi anemia core complex. (PubMed id 22266823)1, 2 Kim H....D'Andrea A.D. (2012)
    8. Lung cancer susceptibility model based on age, family history and genetic variants. (PubMed id 19390575)1, 4 Young R.P....Gamble G.D. (2009)
    9. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. (PubMed id 19661089)1, 4 Hussain S.K....Zhang Z.F. (2009)
    10. A gene-based risk score for lung cancer susceptibilit y in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51455 HGNC: 14060 AceView: REV1L Ensembl:ENSG00000135945 euGenes: HUgn51455
    ECgene: REV1 Kegg: 51455 H-InvDB: REV1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REV1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REV1 gene:
    Search GeneIP for patents involving REV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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