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Aliases for REV1 Gene

Aliases for REV1 Gene

  • REV1, DNA Directed Polymerase 2 3 5
  • Rev1-Like Terminal Deoxycytidyl Transferase 3 4
  • Alpha Integrin-Binding Protein 80 3 4
  • REV1, Polymerase (DNA Directed) 2 3
  • AIBP80 3 4
  • REV1L 3 4
  • REV1 Homolog (S. Cerevisiae) 2
  • REV1 (Yeast Homolog)- Like 2
  • REV1-Like (Yeast) 2
  • REV1 Homolog 3
  • REV1- Like 3
  • EC 2.7.7.- 4

External Ids for REV1 Gene

Previous HGNC Symbols for REV1 Gene

  • REV1L

Previous GeneCards Identifiers for REV1 Gene

  • GC02M100016
  • GC02M093782

Summaries for REV1 Gene

Entrez Gene Summary for REV1 Gene

  • This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

GeneCards Summary for REV1 Gene

REV1 (REV1, DNA Directed Polymerase) is a Protein Coding gene. Diseases associated with REV1 include tick infestation and primary bacterial infectious disease. Among its related pathways are DNA Double-Strand Break Repair and Fanconi anemia pathway. GO annotations related to this gene include magnesium ion binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLH.

UniProtKB/Swiss-Prot for REV1 Gene

  • Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Gene Wiki entry for REV1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REV1 Gene

Genomics for REV1 Gene

Regulatory Elements for REV1 Gene

Promoters for REV1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around REV1 on UCSC Golden Path with GeneCards custom track

Genomic Location for REV1 Gene

Chromosome:
2
Start:
99,400,475 bp from pter
End:
99,490,035 bp from pter
Size:
89,561 bases
Orientation:
Minus strand

Genomic View for REV1 Gene

Genes around REV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REV1 Gene

Proteins for REV1 Gene

  • Protein details for REV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBZ9-REV1_HUMAN
    Recommended name:
    DNA repair protein REV1
    Protein Accession:
    Q9UBZ9
    Secondary Accessions:
    • O95941
    • Q53SI7
    • Q9C0J4
    • Q9NUP2

    Protein attributes for REV1 Gene

    Size:
    1251 amino acids
    Molecular mass:
    138248 Da
    Quaternary structure:
    • Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction with MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK. May bind ITGA3. Interacts with FAAP20/C1orf86.
    SequenceCaution:
    • Sequence=AAK43708.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REV1 Gene

    Alternative splice isoforms for REV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REV1 Gene

Proteomics data for REV1 Gene at MOPED

Post-translational modifications for REV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for REV1 Gene

Domains & Families for REV1 Gene

Gene Families for REV1 Gene

Protein Domains for REV1 Gene

Suggested Antigen Peptide Sequences for REV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBZ9

UniProtKB/Swiss-Prot:

REV1_HUMAN :
  • The C-terminal domain is necessary for protein interactions.
  • Belongs to the DNA polymerase type-Y family.
Domain:
  • The C-terminal domain is necessary for protein interactions.
  • Contains 1 BRCT domain.
  • Contains 1 umuC domain.
Family:
  • Belongs to the DNA polymerase type-Y family.
genes like me logo Genes that share domains with REV1: view

Function for REV1 Gene

Molecular function for REV1 Gene

UniProtKB/Swiss-Prot Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Enzyme Numbers (IUBMB) for REV1 Gene

Gene Ontology (GO) - Molecular Function for REV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11485998
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with REV1: view
genes like me logo Genes that share phenotypes with REV1: view

Animal Models for REV1 Gene

MGI Knock Outs for REV1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for REV1 Gene

Localization for REV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REV1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REV1 Gene COMPARTMENTS Subcellular localization image for REV1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for REV1 Gene

Pathways & Interactions for REV1 Gene

genes like me logo Genes that share pathways with REV1: view

Gene Ontology (GO) - Biological Process for REV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0019985 translesion synthesis TAS --
genes like me logo Genes that share ontologies with REV1: view

No data available for SIGNOR curated interactions for REV1 Gene

Drugs & Compounds for REV1 Gene

(2) Drugs for REV1 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
genes like me logo Genes that share compounds with REV1: view

Transcripts for REV1 Gene

Unigene Clusters for REV1 Gene

REV1, polymerase (DNA directed):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REV1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18 ^
SP1: - - -
SP2:
SP3: - - -
SP4:
SP5: -
SP6: - - - - - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for REV1 Gene

GeneLoc Exon Structure for
REV1
ECgene alternative splicing isoforms for
REV1

Expression for REV1 Gene

mRNA expression in normal human tissues for REV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REV1 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REV1 Gene



SOURCE GeneReport for Unigene cluster for REV1 Gene Hs.443077

mRNA Expression by UniProt/SwissProt for REV1 Gene

Q9UBZ9-REV1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with REV1: view

Protein tissue co-expression partners for REV1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for REV1 Gene

Orthologs for REV1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia REV1 35
  • 81.61 (n)
  • 81.66 (a)
REV1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REV1 35
  • 90.79 (n)
  • 89.83 (a)
REV1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rev1 35
  • 85.6 (n)
  • 84.26 (a)
Rev1 16
Rev1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia REV1 35
  • 99.49 (n)
  • 99.6 (a)
REV1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rev1 35
  • 84.67 (n)
  • 82.38 (a)
oppossum
(Monodelphis domestica)
Mammalia REV1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REV1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves REV1 35
  • 78.52 (n)
  • 78.46 (a)
REV1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia REV1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rev1 35
  • 67.81 (n)
  • 67.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32799 35
zebrafish
(Danio rerio)
Actinopterygii rev1 35
  • 58.3 (n)
  • 56.42 (a)
rev1 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005939 35
  • 47.55 (n)
  • 40.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rev1 35
  • 50.68 (n)
  • 46.79 (a)
Rev1 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rev-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REV1 36
  • 24 (a)
OneToMany
REV1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for REV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REV1 Gene

ENSEMBL:
Gene Tree for REV1 (if available)
TreeFam:
Gene Tree for REV1 (if available)

Paralogs for REV1 Gene

Paralogs for REV1 Gene

Pseudogenes.org Pseudogenes for REV1 Gene

genes like me logo Genes that share paralogs with REV1: view

Variants for REV1 Gene

Sequence variations from dbSNP and Humsavar for REV1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3087403 - 99,442,408(-) CCAGT(A/G)TGCAG nc-transcript-variant, reference, missense
rs3087386 - 99,439,044(-) AGCCT(C/T)TTCCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs3087399 - 99,438,696(-) TGTCA(A/G)TACCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs3087401 - 99,404,482(-) GTGAC(A/G)CAGGA nc-transcript-variant, reference, missense
rs28382882 - 99,438,898(-) ACAGT(A/G)ACACT nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for REV1 Gene

Variant ID Type Subtype PubMed ID
nsv524466 CNV Loss 19592680
esv2658486 CNV Deletion 23128226
nsv874700 CNV Loss 21882294
esv2555492 CNV Deletion 19546169
nsv821279 CNV Deletion 20802225
nsv829580 CNV Loss 20364138
esv2052109 CNV Deletion 18987734
nsv511799 CNV Loss 21212237
esv4405 CNV Deletion 18987735
esv2720432 CNV Deletion 23290073
esv27651 CNV Gain+Loss 19812545
dgv84e180 CNV Gain 20482838
nsv829582 CNV Gain+Loss 20364138
esv33974 CNV Gain+Loss 17666407

Variation tolerance for REV1 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REV1 Gene

HapMap Linkage Disequilibrium report
REV1
Human Gene Mutation Database (HGMD)
REV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REV1 Gene

Disorders for REV1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for REV1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tick infestation
  • tick infestations
primary bacterial infectious disease
fanconi anemia, complementation group a
  • fanconi's anemia
- elite association - COSMIC cancer census association via MalaCards
Search REV1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for REV1

Genetic Association Database (GAD)
REV1
Human Genome Epidemiology (HuGE) Navigator
REV1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REV1
genes like me logo Genes that share disorders with REV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REV1 Gene

Publications for REV1 Gene

  1. The human REV1 gene codes for a DNA template-dependent dCMP transferase. (PMID: 10536157) Lin W. … Wang Z. (Nucleic Acids Res. 1999) 2 3 4 23 67
  2. Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. (PMID: 20028736) Hicks J.K. … Canman C.E. (Mol. Cell. Biol. 2010) 3 23
  3. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. (PMID: 20164194) Hara K. … Sato M. (J. Biol. Chem. 2010) 3 23
  4. Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. (PMID: 19157994) Akagi J. … Hanaoka F. (DNA Repair (Amst.) 2009) 3 23
  5. Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1. (PMID: 18591245) Choi J.Y. … Guengerich F.P. (J. Biol. Chem. 2008) 3 23

Products for REV1 Gene

Sources for REV1 Gene

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