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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

REV1 Gene

protein-coding GIFtS: 55
GCID: GC02M100016

REV1, polymerase (DNA directed)

(Previous names: REV1 (yeast homolog)- like, REV1-like (yeast), REV1 homolog...)
(Previous symbol: REV1L)

Explore 23 diseases affiliated with
REV1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
REV1, Polymerase (DNA Directed)¹ ²		REV1 Homolog (S. Cerevisiae)¹
REV1L¹ ² ³		REV1-Like (Yeast)¹
Alpha Integrin-Binding Protein 80² ³		DNA Repair Protein REV1²
Rev1-Like Terminal Deoxycytidyl Transferase² ³		REV1 Homolog²
AIBP80² ³		REV1- Like²
REV1 (Yeast Homolog)- Like¹		EC 2.7.7.-³

External Ids:	HGNC: 14060¹	Entrez Gene: 51455²	Ensembl: ENSG00000135945⁷	OMIM: 606134⁵	UniProtKB: Q9UBZ9³

Export aliases for REV1 gene to outside databases

Previous GC identifers: GC02M099383 GC02M093782

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REV1:

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a

BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is

as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively

spliced transcript variants that encode different proteins have been found. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9

Function: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA

primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion

of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

Gene Wiki entry for REV1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the REV1 gene promoter:
ER-alpha C/EBPbeta Pbx1a FOXF2 C/EBPalpha Arnt HOXA5 IRF-7A Cart-1 Zic3
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for REV1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REV1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1-q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.1-q11.2

REV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REV1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M100016: view genomic region (about GC identifiers)

Start:	100,016,938 bp from pter	End:	100,106,497 bp from pter
Size:	89,560 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9 (See protein sequence)

Recommended Name: DNA repair protein REV1

Size: 1251 amino acids; 138248 Da

Subunit: Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction with

MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK. May bind

ITGA3. Interacts with FAAP20/C1orf86

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAK43708.1; Type=Erroneous initiation;

5 PDB 3D structures from and Proteopedia for REV1:

2EBW (3D)

2LSK (3D)

2LSY (3D)

3GQC (3D)

3VU7 (3D)

Secondary accessions: O95941 Q53SI7 Q9C0J4 Q9NUP2

Alternative splicing: 3 isoforms: Q9UBZ9-1 Q9UBZ9-2 Q9UBZ9-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for REV1: NX_Q9UBZ9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBZ9

REV1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001032961.1 NP_057400.1

ENSEMBL proteins:

ENSP00000377091 ENSP00000258428 ENSP00000416274 ENSP00000404213 ENSP00000414875

Reactome Protein details: Q9UBZ9
Human Recombinant Protein Products:

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	Novus Biologicals REV1 Protein Novus Biologicals REV1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for REV1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--

REV1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for REV1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

REV1 for domains About GeneDecksing

5 InterPro domains/families:

IPR001126 DNA_repair_prot_UmuC-like

IPR017963 DNA_repair_prot_UmuC-like_N

IPR017961 DNA_pol_Y-fam_little_finger

IPR012112 REV1

IPR001357 BRCT_dom

Graphical View of Domain Structure for InterPro Entry Q9UBZ9

ProtoNet protein and cluster: Q9UBZ9

1 Blocks protein family: IPB001126 UMUC-like DNA-repair protein

UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9

Domain: The C-terminal domain is necessary for protein interactions

Similarity: Belongs to the DNA polymerase type-Y family

Similarity: Contains 1 BRCT domain

Similarity: Contains 1 umuC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9

Function: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA

primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion

of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

Enzyme Number (IUBMB): EC 2.7.7.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): REV1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REV1
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate REV1 (see all 48):
		hsa-miR-124* hsa-miR-3607-3p hsa-miR-3146 hsa-miR-429 hsa-miR-875-5p hsa-miR-139-5p hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: REV1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REV1 (see all 7) OriGene shRNA RFP: REV1 OriGene siRNA: REV1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for REV1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for REV1
		Search LifeMap BioReagents cell lines for REV1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REV1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0003684	damaged DNA binding	IEA	--
GO:0003887	DNA-directed DNA polymerase activity	TAS	--
GO:0005515	protein binding	IPI	--
GO:0017125	deoxycytidyl transferase activity	IEA	--

REV1 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for REV1:

Decreased viability with cispl

Increased cell death in breast

Synthetic lethal with cisplati

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-outs for REV1: Rev1^tm2Ndew Rev1^tm1Ndew
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rev1):

cellular	growth/size	hematopoietic system	immune system	mortality/aging
normal

REV1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translesion synthesis by DNA polymerases bypassing lesion on DNA template

Translesion synthesis by DNA polymerases bypassing lesion on DNA template

1.00

DNA Damage Bypass

1.00

Translesion synthesis by HREV1

Translesion synthesis by HREV1

1.00

Nucleotide Excision Repair

DNA Repair

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for REV1

	DNA Repair
	Translesion synthesis by DNA polymerases bypassing lesion on DNA template
	DNA Damage Bypass
	Translesion synthesis by HREV1

REV1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for REV1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/16 Interacting proteins for REV1 (Q9UBZ9^{2, 3} ENSP00000258428⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAD2L2	Q9UI95²^,³, ENSP00000235310⁴	MINT-8385495 MINT-8385803 MINT-8385833 MINT-8385442 I2D: score=4 STRING: ENSP00000235310
REV3L	O60673², ENSP00000351697⁴	MINT-8385495 MINT-8385803 MINT-8385833 MINT-8385442 STRING: ENSP00000351697
POLH	Q9Y253²^,³, ENSP00000361310⁴	MINT-8385495 MINT-8385863 I2D: score=6 STRING: ENSP00000361310
FHL2	Q14192²^,³, ENSP00000322909⁴	MINT-17606 MINT-17605 I2D: score=3 STRING: ENSP00000322909
POLI	Q9UNA4³, ENSP00000217800⁴	I2D: score=5 STRING: ENSP00000217800

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	IEA	--
GO:0006281	DNA repair	TAS	--
GO:0009411	response to UV	IDA	11485998
GO:0042276	error-prone translesion synthesis	TAS	11485998

REV1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

REV1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for REV1
2 Novoseek chemical compound relationships for REV1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dcmp	73.5	2	11278384 (1), 8977026 (1)
cisplatin	18.4	7	20028736 (4), 16495473 (1)

Search CenterWatch for drugs/clinical trials and news about REV1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for REV1 gene (2 alternative transcripts):

NM_001037872.1 NM_016316.2

Unigene Cluster for REV1:

REV1, polymerase (DNA directed)

Hs.443077 [show with all ESTs]

Unigene Representative Sequence: NM_016316

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393445 ENST00000258428(uc002tac.3 uc002tad.3) ENST00000413697

ENST00000482595 ENST00000465086 ENST00000485487 ENST00000465835 ENST00000438366

ENST00000472000 ENST00000477121 ENST00000481719 ENST00000450415 ENST00000486117

ENST00000491752 ENST00000482887 ENST00000473819(uc002tae.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REV1
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate REV1 (see all 48):
		hsa-miR-124* hsa-miR-3607-3p hsa-miR-3146 hsa-miR-429 hsa-miR-875-5p hsa-miR-139-5p hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: REV1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB047646.1 AF151538.1 AF206019.1 AF357886.1 AJ131720.1 AK002087.1 AK025176.1 AK307719.1

BC037734.1 BC130411.1

20 DOTS entries:

DT.453021 DT.86999396 DT.92022708 DT.95165367 DT.120952324 DT.120952514 DT.120952483 DT.92427023

DT.211288 DT.95243594 DT.453022 DT.120952371 DT.120952481 DT.40121561 DT.95165368 DT.99994551

DT.40119336 DT.95123766 DT.97763025 DT.99975995

24/149 AceView cDNA sequences (see all 149):

AK002087 NM_016316 AF206019 BF981993 BF127653 CF453729 AI206305 BC037734

AJ131720 AW194119 AI432201 BM468065 AI248924 CB149551 BG025670 AF151538

BU682259 CR618059 AA195405 AA746273 AK025176 AI657128 AF357886 CB851608

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for REV1 (see all 13) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16a	·	16b	·	16c	·	16d	^	17a	·	17b	^	18	^
SP1:																					-														-				-
SP2:
SP3:																																			-				-		-
SP4:
SP5:					-

ExUns:	19	^	20	^	21	^	22a	·	22b	·	22c	^	23a	·	23b	^	24a	·	24b
SP1:
SP2:
SP3:
SP4:											-
SP5:

ECgene alternative splicing isoforms for REV1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

REV1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATAATTG

About this image
See REV1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REV1

SOURCE GeneReport for Unigene cluster: Hs.443077

UniProtKB/Swiss-Prot: REV1_HUMAN, Q9UBZ9

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Array including REV1:

DNA Damage Signaling Pathway in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REV1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REV1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for REV1 gene from 9/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	REV1¹	REV1 homolog (S. cerevisiae)	78.92(n) 78.7(a)		418703 NM_001030811.2 NP_001025982.2
lizard (Anolis carolinensis)	Reptilia	REV1⁶	--	69(a)	1 ↔ 1	GL343456.1(79223-126384)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32799²	Xenopus laevis transcribed sequence with weak similarity more	82.67(n)		BJ099195.1
zebrafish (Danio rerio)	Actinopterygii	si:dkey-57a22.7¹	si:dkey-57a22.7	57.91(n) 56.23(a)		570043 NM_001123300.1 NP_001116772.1
fruit fly (Drosophila melanogaster)	Insecta	Rev1¹	CG12189-PA	50.38(n) 46.38(a)		38079 NM_138203.2 NP_612047.1
worm (Caenorhabditis elegans)	Secernentea	rev-1⁶	REV1 (translesion DNA polymerase) homolog family m...	20(a)	1 ↔ 1	II(7900596-7904585)
thale cress (Arabidopsis thaliana)	eudicotyledons	REV1¹	DNA repair protein REV1	46.25(n) 35.4(a)		834504 NM_123842.4 NP_199288.4
rice (Oryza sativa)	Liliopsida	Os06g0691000¹	hypothetical protein	47.48(n) 38.38(a)		4341904 NM_001064954.1 NP_001058419.1
E. coli (Escherichia coli)	Gamma proteobacteria	dinB⁶	DNA polymerase IV	32(a)	1 → many	Chromosome(250898-251953)

ENSEMBL Gene Tree for REV1 (if available)
TreeFam Gene Tree for REV1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for REV1 gene

POLK² POLH² POLI²

REV1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for REV1
PGOHUM00000237511

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189364480^1,2		--	100017236(+)	`TAAGAC/TGGTTT`	2	--	ut3¹		0	--	--	--	--
rs181863083^1,2		--	100017275(+)	`AGAATC/TCCGGT`	2	--	ut3¹		0	--	--	--	--
rs186220725^1,2		--	100017454(+)	`CACTGC/TAAAAA`	2	--	ut3¹		0	--	--	--	--
rs66467104^1,2	C,	--	100017515(+)	`TAAAA-/TAAT TAACA`	2	--	ut3¹		0	--	--	--	--
rs28382979^1,2	F	--	100017521(-)	`TTGTGTTAA/- TTATT`	4	--	ut3¹		5		NS	190
rs3792153^1,2	C,F,H,	--	100017545(-)	`TTTGTC/TAGTAT`	2	--	ut3¹		10		EA NS	2068
rs189026693^1,2		--	100017609(+)	`AAATTA/GTAAAA`	2	--	ut3¹		0	--	--	--	--
rs199687154^1,2		--	100017685(+)	`GAGCAG/TCAGGC`	2	--	ut3¹		0	--	--	--	--
rs146377515^1,2	C,F,	--	100017755(+)	`TGGACA/GTTGTC`	4	N	syn¹		2		NA EU	5873
rs3087387^1,2	C,F,	--	100017868(-)	`ATTAGT/CCTTAA`	2	--	int¹		9		NA NS WA	452

HapMap Linkage Disequilibrium report for REV1 (100016938 - 100106497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for REV1
9 CNVs: 78668 68094 97921 39258 89836 43318 44041 89837 7294
2 Indels: 89838 78669

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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REV1 for disorders           About GeneDecksing

OMIM gene information: 606134    OMIM disorders: --

20/23 diseases for REV1 (see all 23):    About MalaCards

dna topoisomerase ii denture stomatitis xeroderma pigmentosum chronic lymphocytic leukemia

fanconi's anemia lymphocytic leukemia werner syndrome brucellosis

stomach cancer stomatitis lung cancer anemia

cervical carcinoma ovarian carcinoma cervicitis meningioma

leukemia pneumonia carcinoma esophagitis

2 diseases from the University of Copenhagen DISEASES database for REV1:

Brucellosis Xeroderma pigmentosum

Human Genome Epidemiology (HuGE) Navigator: REV1 (8 documents)

Export disorders for REV1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for REV1 gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with REV1)

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The human REV1 gene codes for a DNA template-dependent dCMP transferase. (PubMed id 10536157)^{1, 2, 3, 9} Lin W.... Wang Z. (1999)
Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins. (PubMed id 12529368)^{1, 2, 9} Masuda Y.... Kamiya K. (2003)
Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain. (PubMed id 11278384)^{1, 2, 9} Masuda Y.... Kamiya K. (2001)
The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. (PubMed id 10760286)^{1, 2, 9} Gibbs P.E.M.... Maher V.M. (2000)
Crystal structure of human REV7 in complex with a hum an REV3 fragment and structural implication of the interaction between DNA poly merase zeta and REV1. (PubMed id 20164194)^{1, 2, 9} Hara K....Sato M. (2010)
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. (PubMed id 11485998)^{1, 2, 9} Murakumo Y.... Takahashi M. (2001)
Regulation of Rev1 by the Fanconi anemia core complex. (PubMed id 22266823)^{1, 2} Kim H....D'Andrea A.D. (2012)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains. (PubMed id 10094488)^{1, 2} Wixler V.... Aumailley M. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51455	HGNC: 14060	AceView: REV1L	Ensembl:ENSG00000135945	euGenes: HUgn51455
ECgene: REV1	H-InvDB: REV1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for REV1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for REV1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for REV1 gene:
Search GeneIP for patents involving REV1

GeneCards and IP:
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