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Aliases for RETSAT Gene

Aliases for RETSAT Gene

  • Retinol Saturase (All-Trans-Retinol 13,14-Reductase) 2 3
  • PPAR-Alpha-Regulated And Starvation-Induced Gene Protein 4
  • All-Trans-13,14-Dihydroretinol Saturase 4
  • EC 1.3.99.23 4
  • RetSat 4
  • PPSIG 4

External Ids for RETSAT Gene

Previous GeneCards Identifiers for RETSAT Gene

  • GC02M085422
  • GC02M085569
  • GC02M085466

Summaries for RETSAT Gene

GeneCards Summary for RETSAT Gene

RETSAT (Retinol Saturase (All-Trans-Retinol 13,14-Reductase)) is a Protein Coding gene. Among its related pathways are Vitamin A and carotenoid metabolism and Chemical carcinogenesis. GO annotations related to this gene include oxidoreductase activity and all-trans-retinol 13,14-reductase activity.

UniProtKB/Swiss-Prot for RETSAT Gene

  • Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).

Gene Wiki entry for RETSAT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RETSAT Gene

Genomics for RETSAT Gene

Genomic Location for RETSAT Gene

Start:
85,341,955 bp from pter
End:
85,354,698 bp from pter
Size:
12,744 bases
Orientation:
Minus strand

Genomic View for RETSAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RETSAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RETSAT Gene

Proteins for RETSAT Gene

  • Protein details for RETSAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUM9-RETST_HUMAN
    Recommended name:
    All-trans-retinol 13,14-reductase
    Protein Accession:
    Q6NUM9
    Secondary Accessions:
    • A6NIK3
    • Q53R95
    • Q53SA9
    • Q6UX05
    • Q8N2H5
    • Q96FA4
    • Q9NXE5

    Protein attributes for RETSAT Gene

    Size:
    610 amino acids
    Molecular mass:
    66820 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RETSAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RETSAT Gene

Proteomics data for RETSAT Gene at MOPED

Post-translational modifications for RETSAT Gene

  • Ubiquitination at Lys174 and Lys199
  • Modification sites at PhosphoSitePlus

Other Protein References for RETSAT Gene

No data available for DME Specific Peptides for RETSAT Gene

Domains for RETSAT Gene

Protein Domains for RETSAT Gene

Suggested Antigen Peptide Sequences for RETSAT Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUM9

UniProtKB/Swiss-Prot:

RETST_HUMAN :
  • Q6NUM9
Family:
  • Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.
genes like me logo Genes that share domains with RETSAT: view

No data available for Gene Families for RETSAT Gene

Function for RETSAT Gene

Molecular function for RETSAT Gene

UniProtKB/Swiss-Prot CatalyticActivity: All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor
UniProtKB/Swiss-Prot Function: Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).

Enzyme Numbers (IUBMB) for RETSAT Gene

Gene Ontology (GO) - Molecular Function for RETSAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity ISS 15358783
GO:0051786 all-trans-retinol 13,14-reductase activity ISS 15358783
genes like me logo Genes that share ontologies with RETSAT: view

Phenotypes for RETSAT Gene

GenomeRNAi human phenotypes for RETSAT:
genes like me logo Genes that share phenotypes with RETSAT: view

miRNA for RETSAT Gene

miRTarBase miRNAs that target RETSAT

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RETSAT Gene

Localization for RETSAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RETSAT Gene

Endoplasmic reticulum membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RETSAT Gene COMPARTMENTS Subcellular localization image for RETSAT gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
plasma membrane 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RETSAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005640 nuclear outer membrane ISS 15358783
GO:0005789 endoplasmic reticulum membrane ISS 15358783
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane ISS 15358783
genes like me logo Genes that share ontologies with RETSAT: view

Pathways for RETSAT Gene

genes like me logo Genes that share pathways with RETSAT: view

Pathways by source for RETSAT Gene

1 BioSystems pathway for RETSAT Gene
1 KEGG pathway for RETSAT Gene

Interacting Proteins for RETSAT Gene

Gene Ontology (GO) - Biological Process for RETSAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042572 retinol metabolic process ISS 15358783
GO:0055114 oxidation-reduction process ISS 15358783
genes like me logo Genes that share ontologies with RETSAT: view

Compounds for RETSAT Gene

(5) HMDB Compounds for RETSAT Gene

Compound Synonyms Cas Number PubMed IDs
All-trans-13,14-dihydroretinol
  • 13,14-dihydro-Retinol
115797-14-3
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
Vitamin A
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
68-26-8

(1) Drugbank Compounds for RETSAT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 target
genes like me logo Genes that share compounds with RETSAT: view

Transcripts for RETSAT Gene

Unigene Clusters for RETSAT Gene

Retinol saturase (all-trans-retinol 13,14-reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RETSAT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - -
SP2: - - -
SP3: - - - - - - - -
SP4: -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for RETSAT Gene

GeneLoc Exon Structure for
RETSAT
ECgene alternative splicing isoforms for
RETSAT

Expression for RETSAT Gene

mRNA expression in normal human tissues for RETSAT Gene

mRNA differential expression in normal tissues according to GTEx for RETSAT Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RETSAT Gene

SOURCE GeneReport for Unigene cluster for RETSAT Gene Hs.440401

genes like me logo Genes that share expressions with RETSAT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RETSAT Gene

Orthologs for RETSAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RETSAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RETSAT 35
  • 99.73 (n)
  • 99.67 (a)
RETSAT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RETSAT 35
  • 84.4 (n)
  • 81.08 (a)
RETSAT 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RETSAT 35
  • 84.06 (n)
  • 81.82 (a)
RETSAT 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Retsat 35
  • 82.85 (n)
  • 81.73 (a)
Retsat 16
Retsat 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RETSAT 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RETSAT 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Retsat 35
  • 82.32 (n)
  • 81.25 (a)
chicken
(Gallus gallus)
Aves RETSAT 35
  • 61.22 (n)
  • 55.08 (a)
RETSAT 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RETSAT 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia retsat 35
  • 56.99 (n)
  • 50.69 (a)
Str.5555 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28217 35
retsat 35
  • 56.03 (n)
  • 49.91 (a)
retsat 36
  • 49 (a)
OneToMany
RETSAT (2 of 2) 36
  • 47 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G57770 35
  • 41.49 (n)
  • 29.65 (a)
rice
(Oryza sativa)
Liliopsida Os03g0841900 35
  • 40.81 (n)
  • 29.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for RETSAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RETSAT Gene

ENSEMBL:
Gene Tree for RETSAT (if available)
TreeFam:
Gene Tree for RETSAT (if available)

Paralogs for RETSAT Gene

Pseudogenes.org Pseudogenes for RETSAT Gene

genes like me logo Genes that share paralogs with RETSAT: view

No data available for Paralogs for RETSAT Gene

Variants for RETSAT Gene

Sequence variations from dbSNP and Humsavar for RETSAT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15413 -- 85,342,256(+) ATTAA(C/T)TGCAA utr-variant-3-prime
rs908302 -- 85,345,910(+) GAGCA(A/G)GTTGG intron-variant
rs908303 -- 85,345,919(+) GGCTC(A/C/T)AGAAG intron-variant
rs908304 -- 85,345,926(+) GAAGG(A/G)GACAC intron-variant
rs908305 -- 85,346,259(+) AGTGA(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RETSAT Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV Gain 17160897
esv1004049 OTHER Inversion 20482838
dgv79e19 OTHER Inversion 19470904
nsv7314 OTHER Inversion 18451855
dgv640n67 CNV Loss 20364138
nsv820710 CNV Duplication 20802225
nsv829486 CNV Loss 20364138

Relevant External Links for RETSAT Gene

HapMap Linkage Disequilibrium report
RETSAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RETSAT Gene

Disorders for RETSAT Gene

Relevant External Links for RETSAT

Genetic Association Database (GAD)
RETSAT
genes like me logo Genes that share disorders with RETSAT: view

No data available for UniProtKB/Swiss-Prot for RETSAT Gene

Publications for RETSAT Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. (PMID: 15358783) Moise A.R. … Palczewski K. (J. Biol. Chem. 2004) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for RETSAT Gene

  • antibodies-online proteins for RETSAT
  • antibodies-online antibodies for RETSAT
  • antibodies-online kits for RETSAT

Sources for RETSAT Gene

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