Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RETSAT Gene

protein-coding   GIFtS: 52
GCID: GC02M085569

Retinol Saturase (All-Trans-Retinol 13,14-Reductase)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Retinol Saturase (All-Trans-Retinol 13,14-Reductase)1 2     EC 1.3.99.233
All-Trans-13,14-Dihydroretinol Saturase2 3     PPSIG3
PPAR-Alpha-Regulated And Starvation-Induced Gene Protein2 3     RetSat3
All-Trans-Retinol 13,14-Reductase2     

External Ids:    HGNC: 259911   Entrez Gene: 548842   Ensembl: ENSG000000424457   UniProtKB: Q6NUM93   

Export aliases for RETSAT gene to outside databases

Previous GC identifers: GC02M085422 GC02M085466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RETSAT Gene:
RETSAT (retinol saturase (all-trans-retinol 13,14-reductase)) is a protein-coding gene. GO annotations related to this gene include all-trans-retinol 13,14-reductase activity and oxidoreductase activity.

UniProtKB/Swiss-Prot: RETST_HUMAN, Q6NUM9
Function: Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce
all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use
all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the
metabolism of vitamin A (By similarity)

Gene Wiki entry for RETSAT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RETSAT gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-2alpha isoform 3   E2F-2   AP-2alpha isoform 2   E2F-1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRETSAT promoter sequence
   Search Chromatin IP Primers for RETSAT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RETSAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

RETSAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RETSAT gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M085569:  view genomic region     (about GC identifiers)

Start:
85,569,078 bp from pter      End:
85,581,821 bp from pter
Size:
12,744 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RETST_HUMAN, Q6NUM9 (See protein sequence)
Recommended Name: All-trans-retinol 13,14-reductase precursor  
Size: 610 amino acids; 66820 Da
Cofactor: NAD, NADP, or FAD (By similarity)
Sequence caution: Sequence=AAH11418.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91069.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NIK3 Q53R95 Q53SA9 Q6UX05 Q8N2H5 Q96FA4 Q9NXE5
Alternative splicing: 2 isoforms:  Q6NUM9-1   Q6NUM9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RETSAT: NX_Q6NUM9

Explore proteomics data for RETSAT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys174, Lys199
  • Modification sites at PhosphoSitePlus

  • See RETSAT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060220.3  
    ENSEMBL proteins: 
     ENSP00000388202   ENSP00000295802   ENSP00000412166   ENSP00000444814   ENSP00000387196  
     ENSP00000405040   ENSP00000263854  

    RETSAT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RETSAT
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for RETSAT
    OriGene Custom Protein Services for RETSAT
    GenScript Custom Purified and Recombinant Proteins Services for RETSAT
    Novus Biologicals RETSAT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RETSAT

     
    Search eBioscience for Proteins for RETSAT 

     
    antibodies-online proteins for RETSAT (3 products) 

     
    Search antibodies-online for peptides for RETSAT

    RETSAT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RETSAT
    Novus Biologicals RETSAT Antibodies
    Search for Antibodies for RETSAT at Abcam
    Cloud-Clone Corp. Antibodies for RETSAT
    Search ThermoFisher Antibodies for RETSAT
    antibodies-online antibodies for RETSAT 

    RETSAT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RETSAT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RETSAT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RETSAT
    Cloud-Clone Corp. CLIAs for RETSAT
    Search eBioscience for ELISAs for RETSAT 
    antibodies-online kits for RETSAT (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus

    ProtoNet protein and cluster: Q6NUM9

    1 Blocks protein domain: IPB000408 Regulator of chromosome condensation

    UniProtKB/Swiss-Prot: RETST_HUMAN, Q6NUM9
    Similarity: Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RETST_HUMAN, Q6NUM9
    Function: Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce
    all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use
    all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the
    metabolism of vitamin A (By similarity)
    Catalytic activity: All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor

         Enzyme Number (IUBMB): EC 1.3.99.231

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity ISS15358783
    GO:0051786all-trans-retinol 13,14-reductase activity ISS15358783
         
    Find genes that share ontologies with RETSAT           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RETSAT:
     Increased cell number in G1, s  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Retsat (no phenotypes)

    Find genes that share phenotypes with RETSAT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Retsattm1Lex for RETSAT

       genOway: Develop your customized and physiologically relevant rodent model for RETSAT

    miRNA
    Products:
        
    miRTarBase miRNAs that target RETSAT:
    hsa-mir-30a-5p (MIRT028456), hsa-mir-155-5p (MIRT020592)

    Block miRNA regulation of human, mouse, rat RETSAT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RETSAT (see all 10):
    hsa-miR-320a hsa-miR-345 hsa-miR-607 hsa-miR-3673 hsa-miR-513a-3p hsa-miR-320d hsa-miR-320b hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidRETSAT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RETSAT
    Predesigned siRNA for gene silencing in human, mouse, rat RETSAT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RETSAT

    Clone
    Products:
         
    OriGene clones in human, mouse for RETSAT (see all 7)
    OriGene ORF clones in mouse, rat for RETSAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RETSAT (NM_017750)
    Sino Biological Human cDNA Clone for RETSAT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETSAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETSAT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RETSAT
    Browse ESI BIO Cell Lines and PureStem Progenitors for RETSAT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETSAT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RETST_HUMAN, Q6NUM9: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus3
    plasma membrane2
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005640nuclear outer membrane ISS15358783
    GO:0005789endoplasmic reticulum membrane ISS15358783
    GO:0031965nuclear membrane ISS15358783

    Find genes that share ontologies with RETSAT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RETSAT About    
    See pathways by source

    SuperPathContained pathways About
    1Chemical carcinogenesis
    Retinol metabolism0.35
    2Vitamin A and carotenoid metabolism
    Vitamin A and carotenoid metabolism


    Find genes that share SuperPaths with RETSAT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RETSAT
        Vitamin A and carotenoid metabolism



    1 Kegg Pathway  (Kegg details for RETSAT):
        Retinol metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RETSAT
    Interactions:

        Search GeneGlobe Interaction Network for RETSAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for RETSAT (ENSP000002958024) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    DHRS3ENSP000003653974STRING: ENSP00000365397
    DHRS4ENSP000003262194STRING: ENSP00000326219
    LRATENSP000003372244STRING: ENSP00000337224
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042572retinol metabolic process ISS15358783
    GO:0055114oxidation-reduction process ISS15358783

    Find genes that share ontologies with RETSAT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RETSAT (RETST)

    5 HMDB Compounds for RETSAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    All-trans-13,14-dihydroretinol13,14-dihydro-Retinol (see all 4)115797-14-3--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Vitamin A(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol (see all 7)68-26-8--

    1 DrugBank Compound for RETSAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--17253779



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RETSAT gene: 
    NM_017750.3  

    Unigene Cluster for RETSAT:

    Retinol saturase (all-trans-retinol 13,14-reductase)
    Hs.440401  [show with all ESTs]
    Unigene Representative Sequence: NM_017750
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429806 ENST00000295802(uc010fge.3 uc002spd.3 uc010ysm.2)
    ENST00000449375 ENST00000438611 ENST00000475624 ENST00000409984 ENST00000482694
    ENST00000490291 ENST00000457495 ENST00000263854
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RETSAT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RETSAT (see all 10):
    hsa-miR-320a hsa-miR-345 hsa-miR-607 hsa-miR-3673 hsa-miR-513a-3p hsa-miR-320d hsa-miR-320b hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidRETSAT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RETSAT
    Predesigned siRNA for gene silencing in human, mouse, rat RETSAT
    Clone
    Products:
         
    OriGene clones in human, mouse for RETSAT (see all 7)
    OriGene ORF clones in mouse, rat for RETSAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RETSAT (NM_017750)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETSAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETSAT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RETSAT
    OriGene qSTAR qPCR primer pairs in human, mouse for RETSAT
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RETSAT
      QuantiTect SYBR Green Assays in human, mouse, rat RETSAT
      QuantiFast Probe-based Assays in human, mouse, rat RETSAT

    Additional mRNA sequence: 

    AK000303.1 AK075261.1 AK225305.1 AK296522.1 AL833237.1 AY358568.1 BC011418.1 BC068517.1 

    16 DOTS entries:

    DT.214779  DT.100780691  DT.100780694  DT.92434477  DT.100780690  DT.120978854  DT.95307161  DT.75193627 
    DT.100780692  DT.100715389  DT.100780688  DT.120978832  DT.102842130  DT.120978749  DT.120978807  DT.120978813 

    Selected AceView cDNA sequences (see all 222):

    BQ448420 AI367676 NM_017750 AI954974 BM982673 AY358568 BU624816 BP356540 
    CR615429 BP382236 BQ434490 AW769864 AW611772 AI675726 AI815015 BE747248 
    AI810802 BE018051 BG740827 AA707000 BQ694560 CA444545 BM787250 CR623428 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RETSAT (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                          -                             -                 -                                                         
    SP2:                                                        -                 -                             -                           
    SP3:                    -     -     -     -     -     -     -                 -                                                         
    SP4:                                                                                                              -                     
    SP5:                    -     -                             -                                                                           


    ECgene alternative splicing isoforms for RETSAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RETSAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGGTTAG
    RETSAT Expression
    About this image

    RETSAT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RETSAT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440401
        Custom PCR Arrays for RETSAT
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RETSAT
    OriGene qSTAR qPCR primer pairs in human, mouse for RETSAT
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RETSAT
    QuantiTect SYBR Green Assays in human, mouse, rat RETSAT
    QuantiFast Probe-based Assays in human, mouse, rat RETSAT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETSAT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RETSAT gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Retsat1 , 5 retinol saturase (all trans retinol 13,14 reductase)1, 5 82.85(n)1
    81.73(a)1
      6 (32.27 cM)5
    674421  NM_026159.41  NP_080435.31 
     725984755 
    chicken
    (Gallus gallus)
    Aves RETSAT1 retinol saturase (all-trans-retinol 13,14-reductase) 61.22(n)
    55.08(a)
      426549  XM_424187.4  XP_424187.3 
    lizard
    (Anolis carolinensis)
    Reptilia RETSAT6
    retinol saturase (all-trans-retinol 13,14-reductas...
    58(a)
    1 ↔ 1
    GL343238.1(2508-12242)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.55552 Transcribed sequence with weak similarity to protein more 72.33(n)    BQ525166.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282172 Transcribed sequence with weak similarity to protein more 72.63(n)    BM035735.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G577701 AT1G57770 41.49(n)
    29.65(a)
      842152  NM_104572.3  NP_176088.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g08419001 Os03g0841900 40.81(n)
    29.9(a)
      4334739  NM_001058390.1  NP_001051855.1 


    ENSEMBL Gene Tree for RETSAT (if available)
    TreeFam Gene Tree for RETSAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RETSAT gene

    Find genes that share paralogs with RETSAT           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RETSAT
    PGOHUM00000240708


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RETSAT (see all 412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22296851,2
    C,F,H--85568678(-) GGGCAA/GTGACA 1 -- int16Minor allele frequency- G:0.00MN NS EA NA 442
    rs1493609411,2
    --85568731(+) GGATCC/GTTCCT 1 -- int10--------
    rs19692601,2
    C,F,O,A,H--85568810(+) TGCTGG/ATGGGT 1 -- int128Minor allele frequency- A:0.34MN NS EA NA WA 3034
    rs1462671751,2
    C--85568874(+) CCGGGC/TGTAGG 1 -- int10--------
    rs1381503341,2
    C--85568907(+) CCGCTC/TGTCCA 1 -- int10--------
    rs1153158591,2
    C,F--85568997(+) GTGCCG/ACGGTA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1426820731,2
    --85568998(+) TGCCGC/TGGTAG 1 -- int10--------
    rs1914159811,2
    --85569016(+) GCGGGC/TGGCAA 1 -- int10--------
    rs2011131951,2
    --85569052(+) GGCCT-/GGGGAA 1 -- int10--------
    rs1459887841,2
    --85569081(+) TGTAAC/GTTTAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RETSAT (85569078 - 85581821 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RETSAT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820710CNV Duplication20802225
    dgv640n67CNV Loss20364138
    nsv829486CNV Loss20364138
    nsv834282CNV Gain17160897
    esv1004049OTHER Inversion20482838
    nsv7314OTHER Inversion18451855
    dgv79e19OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RETSAT
    DNA2.0 Custom Variant and Variant Library Synthesis for RETSAT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with RETSAT           About GenesLikeMe

    Genetic Association Database (GAD): RETSAT

    Export disorders for RETSAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RETSAT gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with RETSAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. (PubMed id 15358783)1, 3 Moise A.R....Palczewski K. (J. Biol. Chem. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54884 HGNC: 25991 AceView: FLJ20296 Ensembl:ENSG00000042445 euGenes: HUgn54884
    ECgene: RETSAT Kegg: 54884 H-InvDB: RETSAT

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RETSAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RETSAT gene:
    Search GeneIP for patents involving RETSAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RETSAT  
     OriGene qPCR primer pairs and template standards for RETSAT   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec for RETSAT   OriGene clones in human, mouse for RETSAT  
     OriGene qSTAR qPCR primer pairs in human, mouse for RETSAT   OriGene Purified Protein for RETSAT  
     OriGene ORF clones in mouse, rat for RETSAT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RETSAT   OriGene Custom Protein Services for RETSAT  

     
     
     Block miRNA regulation of human, mouse, rat RETSAT using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RETSAT
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RETSAT Predesigned siRNA for gene silencing in human, mouse, rat RETSAT
     QuantiFast Probe-based Assays in human, mouse, rat RETSAT QuantiTect SYBR Green Assays in human, mouse, rat RETSAT
     Custom PCR Arrays for RETSAT Search Chromatin IP Primers for RETSAT
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RETSAT Search GeneGlobe Interaction Network for RETSAT
     Regulatory tfbs in RETSAT promoter
     GenScript Custom Purified and Recombinant Proteins Services for RETSAT GenScript cDNA clones with any tag delivered in your preferred vector for RETSAT
     GenScript Custom Assay Services for RETSAT GenScript Custom overexpressing Cell Line Services for RETSAT
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RETSAT (RETST)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RETSAT
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RETSAT antibodies
     RETSAT lysates
     Search for Antibodies for RETSAT at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RETSAT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RETSAT
     Antibodies for RETSAT
     ELISAs for RETSAT
     CLIAs for RETSAT



     Browse ESI BIO Cell Lines and PureStem Progenitors for RETSAT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETSAT
     SwitchGear 3'UTR luciferase reporter plasmids for RETSAT
     SwitchGear Promoter luciferase reporter plasmids for RETSAT
     Search ThermoFisher Antibodies for RETSAT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETSAT
     Browse compounds at ApexBio
     Search Addgene for plasmids for RETSAT
      Search eBioscience for proteins for RETSAT
      Search eBioscience for elisas for RETSAT
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RETSAT
     antibodies-online antibodies for RETSAT
     antibodies-online kits for RETSAT (6 products)
      Search antibodies-online for peptides for RETSAT
     antibodies-online proteins for RETSAT (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RETSAT gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4