Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RETSAT Gene

protein-coding GIFtS: 50
GCID: GC02M085569

retinol saturase (all-trans-retinol 13,14-reductase)

Explore 1 disease affiliated with
RETSAT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Retinol Saturase (All-Trans-Retinol 13,14-Reductase)¹ ²		All-Trans-Retinol 13,14-Reductase²
All-Trans-13,14-Dihydroretinol Saturase² ³		EC 1.3.99.23³
PPAR-Alpha-Regulated And Starvation-Induced Gene Protein² ³		PPSIG³
FLJ20296¹		RetSat³

External Ids:	HGNC: 25991¹	Entrez Gene: 54884²	Ensembl: ENSG00000042445⁷	UniProtKB: Q6NUM9³

Export aliases for RETSAT gene to outside databases

Previous GC identifers: GC02M085422 GC02M085466

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RETST_HUMAN, Q6NUM9

Function: Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce

all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic

acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By

similarity)

Gene Wiki entry for RETSAT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RETSAT gene promoter:
E2F-4 E2F-3a E2F-5 AP-2alpha isoform 3 E2F-2 AP-2alpha isoform 2 E2F-1 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RETSAT promoter sequence

Search SABiosciences Chromatin IP Primers for RETSAT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RETSAT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2

RETSAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RETSAT gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M085569: view genomic region (about GC identifiers)

Start:	85,569,078 bp from pter	End:	85,581,821 bp from pter
Size:	12,744 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RETST_HUMAN, Q6NUM9 (See protein sequence)

Recommended Name: All-trans-retinol 13,14-reductase precursor

Size: 610 amino acids; 66820 Da

Cofactor: NAD, NADP, or FAD (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity)

Sequence caution: Sequence=AAH11418.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA91069.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A6NIK3 Q53R95 Q53SA9 Q6UX05 Q8N2H5 Q96FA4 Q9NXE5

Alternative splicing: 2 isoforms: Q6NUM9-1 Q6NUM9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RETSAT: NX_Q6NUM9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6NUM9

RETSAT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060220.3

ENSEMBL proteins:

ENSP00000388202 ENSP00000295802 ENSP00000412166 ENSP00000444814 ENSP00000387196

ENSP00000405040 ENSP00000263854

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RETSAT Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for RETSAT
	GenScript Custom Purified and Recombinant Proteins Services for RETSAT
	Novus Biologicals RETSAT Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RETSAT

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005640	nuclear outer membrane	ISS	15358783
GO:0005789	endoplasmic reticulum membrane	ISS	15358783
GO:0031965	nuclear membrane	ISS	15358783

RETSAT for ontologies About GeneDecksing

RETSAT Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RETSAT
	GenScript Custom Superior Antibodies Services for RETSAT
	Novus Biologicals RETSAT Antibodies
	Search for Antibodies for RETSAT at Abcam
	Uscn Antibodies for RETSAT
	Search ThermoFisher Antibodies for RETSAT

Assay Products for RETSAT:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RETSAT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RETSAT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6NUM9

1 Blocks protein family: IPB000408 Regulator of chromosome condensation

UniProtKB/Swiss-Prot: RETST_HUMAN, Q6NUM9

Similarity: Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RETST_HUMAN, Q6NUM9

Function: Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce

all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic

acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By

similarity)

Catalytic activity: All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor

Enzyme Number (IUBMB): EC 1.3.99.23¹

miRNA Products:		OriGene 3'-UTR Clone: RETSAT Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RETSAT
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RETSAT (see all 10):
		hsa-miR-320a hsa-miR-345 hsa-miR-607 hsa-miR-3673 hsa-miR-513a-3p hsa-miR-320d hsa-miR-320b hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: RETSAT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RETSAT (see all 6) OriGene shRNA RFP: RETSAT OriGene siRNA: RETSAT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETSAT

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RETSAT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RETSAT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RETSAT OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RETSAT (NM_017750)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETSAT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETSAT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RETSAT
		Search LifeMap BioReagents cell lines for RETSAT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETSAT

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016491	oxidoreductase activity	ISS	15358783
GO:0051786	all-trans-retinol 13,14-reductase activity	ISS	15358783

RETSAT for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RETSAT:

Increased cell number in G1, s

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Retsat^tm1Lex for RETSAT
1 MGI phenotypic allele

for Retsat (no phenotypes)

RETSAT for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Vitamin A and carotenoid metabolism

Vitamin A and carotenoid metabolism

1.00

Drug metabolism - cytochrome P450

Retinol metabolism

0.40

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for RETSAT

Vitamin A and carotenoid metabolism

1 Kegg Pathway (Kegg details for RETSAT):

Retinol metabolism

RETSAT for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RETSAT

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/19 Interacting proteins for RETSAT (ENSP00000295802⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668
ADH1B	ENSP00000306606⁴	STRING: ENSP00000306606
ADH5	ENSP00000296412⁴	STRING: ENSP00000296412
CYP26A1	ENSP00000224356⁴	STRING: ENSP00000224356
DHRS3	ENSP00000365397⁴	STRING: ENSP00000365397

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042572	retinol metabolic process	ISS	15358783
GO:0055114	oxidation-reduction process	ISS	15358783

RETSAT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RETSAT

5 HMDB Compounds for RETSAT About this table

Compound	Synonyms	CAS #	PubMed Ids
All-trans-13,14-dihydroretinol	13,14-dihydro-Retinol (see all 4)	115797-14-3	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
Vitamin A	(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol (see all 7)	68-26-8	--

1 DrugBank Compound for RETSAT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin A	[11,12-3H]-Retinol (see all 18)	68-26-8	target	--	17253779

Search CenterWatch for drugs/clinical trials and news about RETSAT / RETST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RETSAT gene:

NM_017750.3

Unigene Cluster for RETSAT:

Retinol saturase (all-trans-retinol 13,14-reductase)

Hs.440401 [show with all ESTs]

Unigene Representative Sequence: NM_017750

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000429806 ENST00000295802(uc010fge.3 uc002spd.3 uc010ysm.2)

ENST00000449375 ENST00000438611 ENST00000475624 ENST00000409984 ENST00000482694

ENST00000490291 ENST00000457495 ENST00000263854

miRNA Products:		OriGene 3'-UTR Clone: RETSAT Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RETSAT
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RETSAT (see all 10):
		hsa-miR-320a hsa-miR-345 hsa-miR-607 hsa-miR-3673 hsa-miR-513a-3p hsa-miR-320d hsa-miR-320b hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: RETSAT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RETSAT (see all 6) OriGene shRNA RFP: RETSAT OriGene siRNA: RETSAT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETSAT

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RETSAT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RETSAT OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RETSAT (NM_017750)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETSAT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETSAT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RETSAT Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat RETSAT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETSAT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETSAT

Additional cDNA sequence:

AK000303.1 AK075261.1 AK225305.1 AK296522.1 AL833237.1 AY358568.1 BC011418.1 BC068517.1

16 DOTS entries:

DT.214779 DT.100780691 DT.100780694 DT.92434477 DT.100780690 DT.120978854 DT.95307161 DT.75193627

DT.100780692 DT.100715389 DT.100780688 DT.120978832 DT.102842130 DT.120978749 DT.120978807 DT.120978813

24/222 AceView cDNA sequences (see all 222):

BM673085 AI991886 AW769864 BE018051 BQ016674 CA444545 AA318288 NM_017750

T32655 CR623428 CR590025 AL833237 BU624816 CR615429 CD628569 AI815015

BG740827 AA903746 AA603987 BP356540 AI810802 AY358568 BQ694560 AA707000

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RETSAT (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	·	11c
SP1:									-										-						-
SP2:																			-						-										-
SP3:							-		-		-		-		-		-		-						-
SP4:																																					-
SP5:							-		-										-

ECgene alternative splicing isoforms for RETSAT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RETSAT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGGGTTAG

About this image
See RETSAT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RETSAT

SOURCE GeneReport for Unigene cluster: Hs.440401

SABiosciences Custom PCR Arrays for RETSAT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RETSAT Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat RETSAT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETSAT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETSAT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETSAT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RETSAT gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Retsat^{1 , 5}	retinol saturase (all trans retinol 13,14 reductase)^{1, 5}	82.62(n)¹ 81.25(a)¹		6 (32.27 cM)⁵ 67442¹ NM_026159.4¹ NP_080435.3¹ 72598475⁵
chicken (Gallus gallus)	Aves	RETSAT¹	retinol saturase (all-trans-retinol 13,14-reductase)	60.75(n) 54.56(a)		426549 XM_424187.3 XP_424187.3
lizard (Anolis carolinensis)	Reptilia	RETSAT⁶ --	--	57(a) 48(a)	many → 1 many → 1	GL343238.1(2559-11499) GL343367.1(1116897-1128343)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.5555²	Transcribed sequence with weak similarity to protein more	72.33(n)		BQ525166.1
zebrafish (Danio rerio)	Actinopterygii	Dr.28217²	Transcribed sequence with weak similarity to protein more	72.63(n)		BM035735.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G57770¹	FAD/NAD(P)-binding oxidoreductase domain-containing more	40.99(n) 28.78(a)		842152 NM_104572.3 NP_176088.2
rice (Oryza sativa)	Liliopsida	Os03g0841900¹	hypothetical protein	40.46(n) 29.44(a)		4334739 NM_001058390.1 NP_001051855.1

ENSEMBL Gene Tree for RETSAT (if available)
TreeFam Gene Tree for RETSAT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RETSAT gene

RETSAT for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RETSAT
PGOHUM00000240708

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2229685^1,2	C,F,H	--	85568678(-)	`GGGCAA/GTGACA`	1	--	int¹		6		MN NS EA NA	442
rs149360941^1,2		--	85568731(+)	`GGATCC/GTTCCT`	1	--	int¹		0	--	--	--	--
rs1969260^1,2	C,F,O,A,H,	--	85568810(+)	`TGCTGG/ATGGGT`	1	--	int¹		28		MN NS EA NA WA	3034
rs146267175^1,2		--	85568874(+)	`CCGGGC/TGTAGG`	1	--	int¹		0	--	--	--	--
rs138150334^1,2		--	85568907(+)	`CCGCTC/TGTCCA`	1	--	int¹		0	--	--	--	--
rs115315859^1,2	F,	--	85568997(+)	`GTGCCG/ACGGTA`	1	--	int¹		1		NA	120
rs142682073^1,2		--	85568998(+)	`TGCCGC/TGGTAG`	1	--	int¹		0	--	--	--	--
rs191415981^1,2		--	85569016(+)	`GCGGGC/TGGCAA`	1	--	int¹		0	--	--	--	--
rs201113195^1,2		--	85569052(+)	`GGCCT-/GGGGAA`	1	--	int¹		0	--	--	--	--
rs145988784^1,2		--	85569081(+)	`TGTAAC/GTTTAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RETSAT (85569078 - 85581821 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RETSAT
2 Inversions: 59896 37223

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RETSAT

DNA2.0 Custom Variant and Variant Library Synthesis for RETSAT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RETSAT for disorders About GeneDecksing

1 disease for RETSAT: About MalaCards

obesity

Export disorders for RETSAT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RETSAT gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with RETSAT)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of all-trans-retinol:all-trans-13,14-d ihydroretinol saturase. (PubMed id 15358783)^{1, 3} Moise A.R....Palczewski K. (2004)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54884	HGNC: 25991	AceView: FLJ20296	Ensembl:ENSG00000042445	euGenes: HUgn54884
ECgene: RETSAT	Kegg: 54884	H-InvDB: RETSAT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RETSAT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RETSAT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RETSAT gene:
Search GeneIP for patents involving RETSAT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for RETSAT
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RETSAT		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RETSAT
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RETSAT		OriGene 3'-UTR Clone for RETSAT
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RETSAT		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RETSAT
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for RETSAT		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RETSAT		OriGene Custom Protein Services for RETSAT
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RETSAT
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RETSAT
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RETSAT
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETSAT
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETSAT
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETSAT

	GenScript Custom Purified and Recombinant Proteins Services for RETSAT		GenScript cDNA clones with any tag delivered in your preferred vector for RETSAT
	GenScript Custom Assay Services for RETSAT		GenScript Custom Superior Antibodies Services for RETSAT
	GenScript Custom overexpressing Cell Line Services for RETSAT		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RETSAT promoter
	Search Chromatin IP Primers for RETSAT
	Search RT² qPCR Primer Assays in human, mouse, rat RETSAT
	Search GNC Networks for RETSAT
	SABiosciences Custom PCR Arrays for RETSAT

Search Tocris compounds for RETSAT

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RETSAT antibodies
	RETSAT lysates

	Search for Antibodies for RETSAT at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for RETSAT
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RETSAT Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RETSAT

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETSAT

	SwitchGear 3'UTR luciferase reporter plasmids for RETSAT
	SwitchGear Promoter luciferase reporter plasmids for RETSAT

Search ThermoFisher Antibodies for RETSAT

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETSAT

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RETSAT gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RETSAT Gene

retinol saturase (all-trans-retinol 13,14-reductase)

Aliases
for RETSAT gene

Summaries
for RETSAT gene

Genomic Views
for RETSAT gene

Proteins
for RETSAT gene

Protein Domains /
Families
for RETSAT gene

Function
for RETSAT gene

Pathways & Interactions
for RETSAT gene

Drugs & Compounds
for RETSAT gene

Transcripts
for RETSAT gene

Expression
for RETSAT gene

Orthologs
for RETSAT gene

Paralogs
for RETSAT gene

Genomic Variants
for RETSAT gene

Disorders / Diseases
for RETSAT gene

Publications
for RETSAT gene

External Searches for RETSAT gene

Genome Databases showing RETSAT gene

Other Databases showing RETSAT gene

Specialized Databases showing RETSAT gene

Intellectual Property
for RETSAT gene

Products
for RETSAT gene

View Random Gene

Advanced Search

Export list of displayed genes

RETSAT Gene

retinol saturase (all-trans-retinol 13,14-reductase)

Aliasesfor RETSAT gene

Summariesfor RETSAT gene

Genomic Viewsfor RETSAT gene

Proteinsfor RETSAT gene

Protein Domains /Familiesfor RETSAT gene

Functionfor RETSAT gene

Pathways & Interactionsfor RETSAT gene

Drugs & Compoundsfor RETSAT gene

Transcriptsfor RETSAT gene

Expression for RETSAT gene

Orthologsfor RETSAT gene

Paralogsfor RETSAT gene

Genomic Variantsfor RETSAT gene

Disorders / Diseasesfor RETSAT gene

Publicationsfor RETSAT gene

External Searches for RETSAT gene

Genome Databases showing RETSAT gene

Other Databases showing RETSAT gene

Specialized Databases showing RETSAT gene

Intellectual Propertyfor RETSAT gene

Productsfor RETSAT gene

View Random Gene

Aliases
for RETSAT gene

Summaries
for RETSAT gene

Genomic Views
for RETSAT gene

Proteins
for RETSAT gene

Protein Domains /
Families
for RETSAT gene

Function
for RETSAT gene

Pathways & Interactions
for RETSAT gene

Drugs & Compounds
for RETSAT gene

Transcripts
for RETSAT gene

Expression
for RETSAT gene

Orthologs
for RETSAT gene

Paralogs
for RETSAT gene

Genomic Variants
for RETSAT gene

Disorders / Diseases
for RETSAT gene

Publications
for RETSAT gene

Intellectual Property
for RETSAT gene

Products
for RETSAT gene