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Aliases for RETNLB Gene

Aliases for RETNLB Gene

  • Resistin Like Beta 2 3
  • Colon And Small Intestine-Specific Cysteine-Rich Protein 3 4
  • Cysteine-Rich Secreted Protein A12-Alpha-Like 1 3 4
  • Colon Carcinoma-Related Gene Protein 3 4
  • Cysteine-Rich Secreted Protein FIZZ2 3 4
  • RELMbeta 3 4
  • FIZZ2 3 4
  • HXCP2 3 4
  • C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Precursor 2 3
  • Cysteine-Rich Secreted A12-Alpha-Like Protein 1 3
  • Found In Inflammatory Zone 1 3
  • RELM-Beta 3
  • RETNL2 4
  • FIZZ1 3
  • RELMb 3
  • XCP2 3
  • CCRG 4

External Ids for RETNLB Gene

Previous GeneCards Identifiers for RETNLB Gene

  • GC03M108001
  • GC03M109755
  • GC03M109794
  • GC03M109956
  • GC03M108462
  • GC03M105848

Summaries for RETNLB Gene

GeneCards Summary for RETNLB Gene

RETNLB (Resistin Like Beta) is a Protein Coding gene. Diseases associated with RETNLB include barrett esophagus/esophageal adenocarcinoma. Among its related pathways are IL4-mediated signaling events. GO annotations related to this gene include hormone activity. An important paralog of this gene is RETN.

UniProtKB/Swiss-Prot for RETNLB Gene

  • Probable hormone

Gene Wiki entry for RETNLB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RETNLB Gene

Genomics for RETNLB Gene

Regulatory Elements for RETNLB Gene

Genomic Location for RETNLB Gene

Chromosome:
3
Start:
108,743,424 bp from pter
End:
108,757,384 bp from pter
Size:
13,961 bases
Orientation:
Minus strand

Genomic View for RETNLB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RETNLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RETNLB Gene

Proteins for RETNLB Gene

  • Protein details for RETNLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ08-RETNB_HUMAN
    Recommended name:
    Resistin-like beta
    Protein Accession:
    Q9BQ08
    Secondary Accessions:
    • Q14D27

    Protein attributes for RETNLB Gene

    Size:
    111 amino acids
    Molecular mass:
    11730 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for RETNLB Gene

Proteomics data for RETNLB Gene at MOPED

Post-translational modifications for RETNLB Gene

No Post-translational modifications

Other Protein References for RETNLB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RETNLB Gene

Domains & Families for RETNLB Gene

Protein Domains for RETNLB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RETNLB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ08

UniProtKB/Swiss-Prot:

RETNB_HUMAN :
  • Belongs to the resistin/FIZZ family.
Family:
  • Belongs to the resistin/FIZZ family.
genes like me logo Genes that share domains with RETNLB: view

No data available for Gene Families for RETNLB Gene

Function for RETNLB Gene

Molecular function for RETNLB Gene

UniProtKB/Swiss-Prot Function:
Probable hormone

Gene Ontology (GO) - Molecular Function for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with RETNLB: view
genes like me logo Genes that share phenotypes with RETNLB: view

Animal Models for RETNLB Gene

MGI Knock Outs for RETNLB:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RETNLB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for RETNLB Gene

Localization for RETNLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RETNLB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RETNLB Gene COMPARTMENTS Subcellular localization image for RETNLB gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RETNLB: view

Pathways & Interactions for RETNLB Gene

SuperPathways for RETNLB Gene

genes like me logo Genes that share pathways with RETNLB: view

Pathways by source for RETNLB Gene

1 BioSystems pathway for RETNLB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for RETNLB Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295755%0d%0a9606.ENSP00000300134%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: ENSP00000295755 for RETNLB Gene via STRING

Gene Ontology (GO) - Biological Process for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation NAS 11209052
genes like me logo Genes that share ontologies with RETNLB: view

No data available for SIGNOR curated interactions for RETNLB Gene

Drugs & Compounds for RETNLB Gene

(1) Drugs for RETNLB Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cysteine Nutra 143
genes like me logo Genes that share compounds with RETNLB: view

Transcripts for RETNLB Gene

mRNA/cDNA for RETNLB Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RETNLB Gene

Resistin like beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RETNLB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RETNLB Gene

No ASD Table

Relevant External Links for RETNLB Gene

GeneLoc Exon Structure for
RETNLB
ECgene alternative splicing isoforms for
RETNLB

Expression for RETNLB Gene

mRNA expression in normal human tissues for RETNLB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RETNLB Gene

This gene is overexpressed in Colon - Transverse (x34.1) and Small Intestine - Terminal Ileum (x16.9).

SOURCE GeneReport for Unigene cluster for RETNLB Gene Hs.307047

mRNA Expression by UniProt/SwissProt for RETNLB Gene

Q9BQ08-RETNB_HUMAN
Tissue specificity: Expressed only in the gastrointestinal tract, particularly the colon
genes like me logo Genes that share expression patterns with RETNLB: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RETNLB Gene

Orthologs for RETNLB Gene

This gene was present in the common ancestor of chordates.

Orthologs for RETNLB Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RETNLB 35
  • 75.47 (n)
  • 68.87 (a)
mouse
(Mus musculus)
Mammalia Retnlb 35
  • 73.4 (n)
  • 60.58 (a)
Retnlb 16
Retnla 36
  • 41 (a)
OneToMany
Retnlb 36
  • 60 (a)
OneToMany
Retnlg 36
  • 51 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RETNLB 35
  • 99.4 (n)
  • 98.2 (a)
RETNLB 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Retnlb 35
  • 71.43 (n)
  • 60 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
Species with no ortholog for RETNLB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RETNLB Gene

ENSEMBL:
Gene Tree for RETNLB (if available)
TreeFam:
Gene Tree for RETNLB (if available)

Paralogs for RETNLB Gene

Paralogs for RETNLB Gene

(2) SIMAP similar genes for RETNLB Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RETNLB Gene

genes like me logo Genes that share paralogs with RETNLB: view

Variants for RETNLB Gene

Sequence variations from dbSNP and Humsavar for RETNLB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1107337 -- 108,756,961(-) CCCAA(C/T)CAAGC intron-variant
rs1374821 -- 108,755,660(-) GGGTA(A/G)TAAAG utr-variant-3-prime
rs2218633 -- 108,758,165(-) TCTAG(A/G)GAAAG upstream-variant-2KB
rs2399237 -- 108,758,430(+) tgaat(A/C)ttaat upstream-variant-2KB
rs3811687 -- 108,757,672(-) CCCAG(A/G)TGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RETNLB Gene

Variant ID Type Subtype PubMed ID
nsv829659 CNV Gain 17160897
esv2670614 CNV Deletion 23128226
nsv829661 CNV Gain 17160897
nsv522119 CNV Gain 19592680

Variation tolerance for RETNLB Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RETNLB Gene

HapMap Linkage Disequilibrium report
RETNLB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RETNLB Gene

Disorders for RETNLB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RETNLB Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
barrett esophagus/esophageal adenocarcinoma
  • barrett's esophagus
- elite association

Relevant External Links for RETNLB

Genetic Association Database (GAD)
RETNLB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RETNLB
genes like me logo Genes that share disorders with RETNLB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RETNLB Gene

Publications for RETNLB Gene

  1. Expression of resistin-like molecule beta in Barrett's esophagus: a novel biomarker for metaplastic epithelium. (PMID: 19225886) Zheng L. … Hou X. (Dig. Dis. Sci. 2010) 23 67
  2. Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis. (PMID: 19967544) Zheng L. … Tong Q. (Virchows Arch. 2010) 23 67
  3. Enhanced expression of resistin-like molecule beta in human colon cancer and its clinical significance. (PMID: 18594973) Zheng L.D. … Hou X.H. (Dig. Dis. Sci. 2009) 23 67
  4. Regulation of gut-derived resistin-like molecule beta expression by nutrients. (PMID: 17936398) Fujio J. … Asano T. (Diabetes Res. Clin. Pract. 2008) 23 67
  5. Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2? (PMID: 18467915) Te Velde A.A. … Stokkers P.C. (Eur J Gastroenterol Hepatol 2008) 23 67

Products for RETNLB Gene

Sources for RETNLB Gene

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