RETNLB Gene
protein-coding GIFtS: 51
GCID: GC03M108462
|
|
resistin like beta
| |
Aliases
for RETNLB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Resistin Like Beta1 2 | | FIZZ12 | | FIZZ21 2 3 | | RELM-Beta1 | | HXCP21 2 3 | | XCP22 | | RELMb1 2 | | C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich ProteinPrecursor 22 | | Colon And Small Intestine-Specific Cysteine-Rich Protein2 3 | | Cysteine-Rich Secreted A12-Alpha-Like Protein 12 | | Colon Carcinoma-Related Gene Protein2 3 | | Found In Inflammatory Zone 12 | | Cysteine-Rich Secreted Protein A12-Alpha-Like 12 3 | | Resistin-Like Beta2 | | Cysteine-Rich Secreted Protein FIZZ22 3 | | CCRG3 | | RELMbeta2 3 | | RETNL23 |
Export aliases for RETNLB gene to outside databasesPrevious GC identifers: GC03M108001 GC03M109755 GC03M109794 GC03M109956 GC03M105848 |
Summaries
for RETNLB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RETNB_HUMAN, Q9BQ08Function: Probable hormone
Gene Wiki entry for RETNLB
|
Genomic Views
for RETNLB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RETNLB gene promoter:
Sox5 p53 MyoD Tal-1beta E47 Meis-1b C/EBPalpha RORalpha1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RETNLB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RETNLB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.1 Ensembl cytogenetic band: 3q13.13 HGNC cytogenetic band: 3q13.1RETNLB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M108462: view genomic region
(about GC identifiers)
Start:
|
108,462,271 bp from pter |
End:
|
108,476,231 bp from pter |
Size:
|
13,961 bases |
Orientation:
|
minus strand |
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Proteins
for RETNLB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RETNB_HUMAN, Q9BQ08 (See
protein sequence)Recommended Name: Resistin-like beta precursor Size: 111 amino acids; 11730 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted
Secondary accessions: Q14D27Explore the universe of human proteins at neXtProt for RETNLB: NX_Q9BQ08
RETNLB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115968.1
ENSEMBL proteins: ENSP00000295755
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005576 | extracellular region |
IEA | -- |
RETNLB for ontologies About GeneDecksing
RETNLB Antibody Products:
Assay Products for RETNLB: |
Protein
Domains /
Families
for RETNLB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RETNLB for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BQ08ProtoNet protein and cluster: Q9BQ08 1 Blocks protein family: IPB009714 Resistin
UniProtKB/Swiss-Prot: RETNB_HUMAN, Q9BQ08Similarity: Belongs to the resistin/FIZZ family |
Function
for RETNLB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RETNB_HUMAN, Q9BQ08Function: Probable hormone
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RETNLB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RETNLB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RETNLB (NM_032579) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RETNLB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETNLB |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005179 | hormone activity |
IEA | -- |
RETNLB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RETNLB:
Animal Models:
Mouse knock-out Retnlbtm1Gdw for RETNLB
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Retnlb):
RETNLB for phenotypes About GeneDecksing
|
Pathways & Interactions
for RETNLB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Selected targets of C/EBPbeta | | | 2 | IL4-mediated signaling events | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RETNLB
1  BioSystems Pathway for RETNLB
RETNLB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RETNLB
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for RETNLB (ENSP000002957554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
RETNLB for ontologies About GeneDecksing
|
Drugs & Compounds
for RETNLB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RETNLB for compounds About GeneDecksing
 Browse Tocris compounds for RETNLB
1 Novoseek chemical compound relationship for RETNLB gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cysteine |
15.4 |
1 |
11358969 (1) |
Search CenterWatch for drugs/clinical trials and news about RETNLB / RETNB
|
Transcripts
for RETNLB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RETNLB gene: NM_032579.2 Unigene Cluster for RETNLB: Resistin like beta Hs.307047 [show with all ESTs]Unigene Representative Sequence: AF3230842 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000482939 ENST00000295755(uc003dxh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RETNLB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RETNLB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RETNLB (NM_032579) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RETNLB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETNLB |
Additional cDNA sequence: AF290873.1 AF323084.1 AM050721.1 AY358655.1 BC069318.1 BC113502.1 BC113528.1 1 DOTS entry: DT.406430 14 AceView cDNA sequences: BC069318 AA570296 BX097733 AY358655 NM_032579 AA515389 AI732336 BX957161 AF323084 AA524300 BX643160 AF290873 AF323921 AI732383
GeneLoc Exon Structure
|
Expression
for RETNLB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RETNLB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGTAATGA
About this image
See RETNLB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RETNLB
SOURCE GeneReport for Unigene cluster: Hs.307047
UniProtKB/Swiss-Prot: RETNB_HUMAN, Q9BQ08Tissue specificity: Expressed only in the gastrointestinal tract, particularly the colon
SABiosciences Expression via Pathway-Focused PCR Array including RETNLB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RETNLB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RETNLB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETNLB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETNLB |
Orthologs
for RETNLB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for RETNLB (if available)
TreeFam Gene Tree for RETNLB (if available) |
Paralogs
for RETNLB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RETNLB gene
- RETN2
2 SIMAP similar genes for RETNLB using alignment to 1 protein entry: RETNB_HUMAN:RELM-beta RETN
RETNLB for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RETNLB
PGOHUM00000237713
|
Genomic Variants
for RETNLB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RETNLB (108462271 - 108476231 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RETNLB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RETNLB |
|
Disorders
/ Diseases
for RETNLB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RETNLB for disorders About GeneDecksing
OMIM gene information: 605645
OMIM disorders: --
14  diseases for RETNLB: About MalaCardscolon carcinoma barrett's esophagus insulin resistance carcinoma
inflammatory bowel disease pulmonary fibrosis pulmonary hypertension scleroderma
fibrosis hypertension colon cancer gastric cancer
asthma hypoxia
1 disease from the University of Copenhagen DISEASES database for RETNLB:Pulmonary fibrosis 2 Novoseek disease relationships for RETNLB gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| insulin resistance |
48.9 |
2 |
16815164 (1), 12531878 (1) |
| barrett esophagus |
48.5 |
1 |
19967544 (1) |
Export disorders for RETNLB gene to outside databases
|
Publications
for RETNLB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RETNLB gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with RETNLB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Bioinformatics based discovery of a novel factor with apparent specificity to colon cancer. (PubMed id 12224133)1, 2, 9 De Young M.P.... Narayanan R. (2002)
- A family of tissue-specific resistin-like molecules. (PubMed id 11209052)1, 2, 9 Steppan C.M.... Lazar M.A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism. (PubMed id 12574343)1, 3 Stutz A.M....Woisetschlager M. (2003)
- Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice. (PubMed id 11090083)1, 2 Kubota T.... Koeffler H.P. (2000)
- FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. (PubMed id 10921885)1, 3 Holcomb I.N.... Hebert C.C. (2000)
- Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis. (PubMed id 19967544)1, 9 Zheng L....Tong Q. (2010)
- Enhanced expression of resistin-like molecule beta in human colon cancer and its clinical significance. (PubMed id 18594973)1, 9 Zheng L.D....Hou X.H. (2009)
- Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia. (PubMed id 16427636)1, 9 Renigunta A....Hanze J. (2006)
|
External Searches for RETNLB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RETNLB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RETNLB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RETNLB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RETNLB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RETNLB gene:
Search GeneIP for patents involving RETNLB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RETNLB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RETNLB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RETNLB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RETNLB | | | OriGene Protein Over-expression Lysate for RETNLB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RETNLB | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RETNLB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RETNLB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RETNLB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RETNLB | | OriGene Custom Protein Services for RETNLB | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RETNLB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RETNLB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RETNLB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETNLB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETNLB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETNLB |
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 |  |  |  | |
| | | | Search Tocris compounds for RETNLB |
| |  |  |  |  | | | | | | Recombinant Protein for RETNLB |
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 | | | | |  |  |  | | | | ThermoFisher Antibodies for RETNLB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETNLB |
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