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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RETN Gene

protein-coding GIFtS: 61
GCID: GC19P007733

resistin

Explore 117 diseases affiliated with
RETN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Resistin¹		Cysteine-Rich Secreted Protein A12-Alpha-Like 2² ³
FIZZ3¹ ² ³ ⁵		Cysteine-Rich Secreted Protein FIZZ3² ³
ADSF¹ ² ³		XCP1²
RSTN² ³ ⁵		C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Precursor 1²
RETN1¹ ²		Found In Inflammatory Zone 3²
Adipose Tissue-Specific Secretory Factor² ³		Resistin Delta2²
C/EBP-Epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein² ³		HXCP1³

External Ids:	HGNC: 20389¹	Entrez Gene: 56729²	Ensembl: ENSG00000104918⁷	OMIM: 605565⁵	UniProtKB: Q9HD89³

Export aliases for RETN gene to outside databases

Previous GC identifers: GC19P007838 GC19P007628 GC19P007639 GC19P007403

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RETN:

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is

the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by

adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript

variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89

Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially

links obesity to diabetes

Gene Wiki entry for RETN (Resistin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_077812.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RETN gene promoter:
Elk-1 AML1a AP-1 p300 ATF-2 MEF-2A IRF-2 c-Jun aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RETN promoter sequence

Search SABiosciences Chromatin IP Primers for RETN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RETN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

RETN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RETN gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P007733: view genomic region (about GC identifiers)

Start:	7,733,972 bp from pter	End:	7,735,340 bp from pter
Size:	1,369 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89 (See protein sequence)

Recommended Name: Resistin precursor

Size: 108 amino acids; 11419 Da

Subunit: Homodimer; disulfide-linked (By similarity)

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for RETN:

1LV6 (3D)

Secondary accessions: D6W649 Q540D9

Explore the universe of human proteins at neXtProt for RETN: NX_Q9HD89

RETN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001180303.1 NP_065148.1

ENSEMBL proteins:

ENSP00000221515 ENSP00000370725

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for RETN (Resistin)
	Enzo Life Sciences proteins for RETN
	OriGene Purified Protein: RETN OriGene Protein Over-expression Lysate: RETN OriGene Custom Protein Services for RETN
	GenScript Custom Purified and Recombinant Proteins Services for RETN
	Novus Biologicals RETN Proteins Novus Biologicals RETN Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RETN
	Uscn Proteins for RETN

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	IEA	--

RETN for ontologies About GeneDecksing

RETN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RETN
	R&D Systems Antibodies for RETN (Resistin)
	OriGene Antibodies (see all 2): RETN OriGene Custom Antibody Services for RETN
	GenScript Custom Superior Antibodies Services for RETN
	Novus Biologicals RETN Antibodies
	Abcam antibodies for RETN
	Uscn Antibodies for RETN
	ThermoFisher Antibody for RETN

Assay Products for RETN:

	EMD Millipore Kits and Assays for the Analysis of RETN
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for RETN (Resistin) (see all)
	GenScript Custom Assay Services for RETN
	Enzo Life Sciences assays for RETN
	Uscn ELISAs and CLIAs for RETN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RETN for domains About GeneDecksing

1 InterPro domain/family:

IPR009714 Resistin

Graphical View of Domain Structure for InterPro Entry Q9HD89

ProtoNet protein and cluster: Q9HD89

1 Blocks protein family: IPB009714 Resistin

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89

Similarity: Belongs to the resistin/FIZZ family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89

Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially

links obesity to diabetes

miRNA Products:		OriGene 3'-UTR Clone: RETN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RETN
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RETN
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RETN (see all 7) OriGene shRNA RFP: RETN OriGene siRNA: RETN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RETN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RETN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RETN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RETN (NM_020415)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RETN
		Search LifeMap BioReagents cell lines for RETN

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RETN

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	NAS	--

RETN for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for RETN:

Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased influenza A H1N1 (A/	Decreased influenza A H1N1 (A/
Decreased influenza A/WSN/33 r	Increased circadian period len

Animal Models:
Mouse knock-out Retn^tm1Lex for RETN
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Retn):

adipose tissue

homeostasis/metabolism

liver/biliary system

RETN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Selected targets of C/EBPbeta

Selected targets of C/EBPbeta

1.00

Selected targets of ESR1

Selected targets of ESR1

1.00

Adipogenesis

Adipogenesis

1.00

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

IL-9 Signaling Pathways

Adipocytokines & Insulin Signaling

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for RETN

	Selected targets of C/EBPbeta
	Selected targets of ESR1
	Selected targets of C/EBPalpha

1 R&D Systems Pathway for RETN

Adipocytokines & Insulin Signaling

1 BioSystems Pathway for RETN

Adipogenesis

RETN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RETN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RETN (Q9HD89³ ENSP00000221515⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SF3A2	Q15428³, ENSP00000221494⁴	I2D: score=1 STRING: ENSP00000221494

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--
GO:0032868	response to insulin stimulus	IEA	--
GO:0045444	fat cell differentiation	IEA	--

RETN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RETN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RETN
10/54 Novoseek chemical compound relationships for RETN gene (see all 54) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	75.7	325	15983036 (6), 19435854 (6), 19130414 (5), 20154025 (5) (see all 99)
rosiglitazone	70.6	46	15741250 (5), 14671216 (4), 17287417 (3), 16254032 (2) (see all 21)
nash	60.3	8	18609175 (2), 16231590 (1), 19693638 (1), 16231364 (1) (see all 7)
lipid	56.6	80	19041881 (3), 17067553 (3), 16497175 (2), 19408174 (2) (see all 58)
cholesterol	55.1	59	17365928 (3), 15034607 (3), 12647275 (2), 19290012 (2) (see all 35)
thiazolidinedione	48.4	3	12660880 (1), 12482590 (1)
pioglitazone	48.4	12	16682836 (3), 16804048 (2), 16118250 (1), 18359318 (1) (see all 6)
metformin	48	12	18446452 (2), 16118250 (1), 15736108 (1), 17224000 (1) (see all 7)
c-peptide	46.1	18	19430715 (3), 19693538 (2), 17010469 (2), 17287417 (1) (see all 11)
fatty acid	42	17	18499762 (2), 20514986 (2), 16685503 (1), 16497175 (1) (see all 14)

Search CenterWatch for drugs/clinical trials and news about RETN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RETN gene (2 alternative transcripts):

NM_001193374.1 NM_020415.3

Unigene Cluster for RETN:

Resistin

Hs.283091 [show with all ESTs]

Unigene Representative Sequence: EL736366

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000221515(uc002mhg.1 uc002mhf.1 uc010dvm.1) ENST00000381324

miRNA Products:		OriGene 3'-UTR Clone: RETN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RETN
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RETN (see all 7) OriGene shRNA RFP: RETN OriGene siRNA: RETN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETN

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		GenScript: all cDNA clones in your preferred vector (see all 2): RETN (NM_020415)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RETN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RETN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETN

Additional cDNA sequence:

AB111910.1 AF205952.1 AF290874.1 AF323081.1 AY207314.1 AY359066.1 BC069302.1 BC101554.1

BC101560.1

2 DOTS entries:

DT.441806 DT.92423483

15 AceView cDNA sequences:

AB111910 BC069302 AF205952 NM_020415 AY207314 AF290874 AF323081 BM682332

AY359066 AA311223 BF590745 BF002026 BM723331 BX282116 N41594

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RETN About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b
SP1:
SP2:			-

ECgene alternative splicing isoforms for RETN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RETN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTGGACCG

About this image

RETN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Adipose

Body Subcutaneous White Adipose

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RETN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RETN

SOURCE GeneReport for Unigene cluster: Hs.283091

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89

Tissue specificity: Expressed only in fatty tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including RETN (see all 6):

Insulin Signaling Pathway in human mouse rat

Cell Surface Markers in human mouse rat

Insulin Resistance in human mouse rat

Diabetes in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RETN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RETN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETN

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RETN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for RETN gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Retn^{1 , 5}	resistin^{1, 5}	67.95(n)¹ 55.77(a)¹		8 (1.92 cM)⁵ 57264¹ NM_001204959.1¹ NP_001191888.1¹ 3655770⁵

ENSEMBL Gene Tree for RETN (if available)
TreeFam Gene Tree for RETN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RETN gene

RETNLB²

2 SIMAP similar genes for RETN using alignment to 2 protein entries: RETN_HUMAN (see all proteins):

RELM-beta RETNLB

RETN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs36204110^1,2	C,	--	7402198(+)	`ACTGTA/GCTCCA`	2	--	us2k¹		0	--	--	--	--
rs12459044^1,2	C,F,H,	--	7402205(+)	`tccagC/Gctgag`	2	--	us2k¹		4		NA	126
rs36204112^1,2	C,F,	--	7402224(+)	`TGAGAC/TTCTGA`	2	--	us2k¹		1		WA	118
rs36204404^1,2	C,F,	--	7402265(+)	`AATGGA/GACAAG`	2	--	us2k¹		1		WA	118
rs7249130^1,2	C,	--	7402491(+)	`aacacA/Ggtgaa`	2	--	us2k¹		0	--	--	--	--
rs36203769^1,2	C,	--	7402585(-)	`CCTGCC/G/TTCAGC`	2	--	us2k¹		0	--	--	--	--
rs36203768^1,2	C,	--	7402589(-)	`TTCTCC/TTGCTT`	2	--	us2k¹		0	--	--	--	--
rs10402306^1,2	C,F,	--	7402598(+)	`aatggC/Tgtgaa`	2	--	us2k¹		3		NA	6
rs3760678^1,2	C,F,	--	7402919(+)	`TTGAGA/GTGGAG`	2	--	us2k¹		9		NS NA EA	430
rs34124816^1,2	C,F,	--	7403475(+)	`TTGTCA/CTGTTT`	2	--	us2k¹		11		NS NA CSA WA EA	546

HapMap Linkage Disequilibrium report for RETN (7733972 - 7735340 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RETN
1 CNV: 8863
Human Gene Mutation Database (HGMD): RETN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RETN

DNA2.0 Custom Variant and Variant Library Synthesis for RETN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RETN for disorders           About GeneDecksing

OMIM gene information: 605565
OMIM disorders: 125853
20/117 diseases for RETN (see all 117):    About MalaCards

diabetes mellitus, noninsulin-dependent hypertension, insulin resistance-related prader-willi syndrome obesity

high blood pressure end stage renal failure retinol binding protein bulimia nervosa

glucose intolerance familial partial lipodystrophy diabetes mellitus insulin resistance

polycystic ovary syndrome myocardial infarction abdominal aortic aneurysm growth hormone deficiency

traumatic brain injury acute myocardial infarction anorexia nervosa nonalcoholic steatohepatitis

8 diseases from the University of Copenhagen DISEASES database for RETN:

Diabetes mellitus Atherosclerosis Fatty liver disease Hyperglycemia

Hypertension Polycystic ovary syndrome Hyperinsulinism Coronary heart disease

10/81 Novoseek disease relationships for RETN gene (see all 81) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	91.5	452	17716671 (5), 17366001 (5), 15111497 (4), 14651328 (4) (see all 99)
obesity	86.1	235	17366001 (5), 16080635 (4), 20346233 (3), 12429047 (3) (see all 99)
insulin sensitivity	84.8	107	16525810 (4), 18230823 (3), 17366001 (3), 18308111 (3) (see all 73)
niddm	71.4	24	14521723 (2), 15034607 (2), 17565416 (1), 12647275 (1) (see all 19)
acquired generalized lipodystrophy	70.8	1	15256772 (1)
inflammation	67.7	185	17366001 (5), 15034607 (5), 18234104 (4), 18709689 (4) (see all 96)
atherosclerosis	66.6	63	18710472 (4), 15710760 (3), 18023360 (2), 16271710 (2) (see all 45)
cardiovascular diseases	65.2	31	18220599 (2), 17175295 (1), 18446183 (1), 19223612 (1) (see all 23)
necrosis	65.2	176	16825020 (2), 19539174 (2), 17882804 (2), 17295762 (2) (see all 99)
fatty liver	64.6	14	19693638 (2), 16284427 (2), 16989692 (1), 18752757 (1) (see all 12)

Genetic Association Database (GAD): RETN
Human Genome Epidemiology (HuGE) Navigator: RETN (76 documents)

Export disorders for RETN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RETN gene, integrated from 9 sources (see all 973):
(articles sorted by number of sources associating them with RETN)

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Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. (PubMed id 12050208)^{1, 3, 4} Wang H....Elbein S.C. (2002)
Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients. (PubMed id 15842513)^{1, 4, 9} Kunnari A....Kesaniemi Y.A. (2005)
Resistin gene 3'-untranslated region +62G-->A polymorphism is associated with hypertension but not diabetes mellitus type 2 in a German population. (PubMed id 16313475)^{1, 4, 9} Gouni-Berthold I....Krone W. (2005)
A resistin gene polymorphism is associated with body mass index in women. (PubMed id 15221446)^{1, 4, 9} Mattevi V.S....Hutz M.H. (2004)
Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study. (PubMed id 15754730)^{1, 4, 9} Bouchard L....Perusse L. (2004)
The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. (PubMed id 15338456)^{1, 4, 9} Osawa H....Makino H. (2004)
Variation in resistin gene promoter not associated with polycystic ovary syndrome. (PubMed id 12502516)^{1, 4, 9} Urbanek M....Legro R.S. (2003)
An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance. (PubMed id 12213907)^{1, 4, 9} Pizzuti A....Frittitta L. (2002)
Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. (PubMed id 15517149)^{1, 4} Conneely K.N....Boehnke M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56729	HGNC: 20389	AceView: RETN	Ensembl:ENSG00000104918	euGenes: HUgn56729
ECgene: RETN	H-InvDB: RETN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RETN	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/retn/

Intellectual Property for RETN gene
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Patent Information for RETN gene:
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RETN Gene

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