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RETN Gene

protein-coding   GIFtS: 60
GCID: GC19P007733

Resistin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
resistin1 2     ADSF2 3
FIZZ32 3 5     RETN12
RSTN2 3 5     XCP12
Adipose Tissue-Specific Secretory Factor2 3     C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein
Precursor 12
C/EBP-Epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein2 3     Found In Inflammatory Zone 32
Cysteine-Rich Secreted Protein A12-Alpha-Like 22 3     Resistin Delta22
Cysteine-Rich Secreted Protein FIZZ32 3     HXCP13

External Ids:    HGNC: 203891   Entrez Gene: 567292   Ensembl: ENSG000001049187   OMIM: 6055655   UniProtKB: Q9HD893   

Export aliases for RETN gene to outside databases

Previous GC identifers: GC19P007838 GC19P007628 GC19P007639 GC19P007403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RETN Gene:
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this
family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is
secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2010)

GeneCards Summary for RETN Gene:
RETN (resistin) is a protein-coding gene. Diseases associated with RETN include hypertension, insulin resistance-related, and acquired generalized lipodystrophy. GO annotations related to this gene include hormone activity. An important paralog of this gene is RETNLB.

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89
Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells.
Potentially links obesity to diabetes

Gene Wiki entry for RETN (Resistin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the RETN gene promoter:
         Elk-1   AML1a   AP-1   p300   ATF-2   MEF-2A   IRF-2   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRETN promoter sequence
   Search Chromatin IP Primers for RETN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RETN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RETN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RETN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007733:  view genomic region     (about GC identifiers)

Start:
7,733,930 bp from pter      End:
7,735,340 bp from pter
Size:
1,411 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89 (See protein sequence)
Recommended Name: Resistin precursor  
Size: 108 amino acids; 11419 Da
Subunit: Homodimer; disulfide-linked (By similarity)
1 PDB 3D structure from and Proteopedia for RETN:
1LV6 (3D)    
Secondary accessions: D6W649 Q540D9

Explore the universe of human proteins at neXtProt for RETN: NX_Q9HD89

Explore proteomics data for RETN at MOPED


See RETN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001180303.1  NP_065148.1  

ENSEMBL proteins: 
 ENSP00000221515   ENSP00000370725  

RETN Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for RETN (Resistin)
Enzo Life Sciences proteins for RETN
OriGene Purified Protein for RETN
OriGene Protein Over-expression Lysate for RETN
OriGene MassSpec for RETN
OriGene Custom Protein Services for RETN
GenScript Custom Purified and Recombinant Proteins Services for RETN
Novus Biologicals RETN Proteins
Novus Biologicals RETN Lysates
Sino Biological Recombinant Protein for RETN
Sino Biological Cell Lysate for RETN
ProSpec Recombinant Protein for RETN
Cloud-Clone Corp. Proteins for RETN

RETN Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of RETN
R&D Systems Antibodies for RETN (Resistin)
OriGene Antibodies for RETN
OriGene Custom Antibody Services for RETN
Novus Biologicals RETN Antibodies
Abcam antibodies for RETN
Cloud-Clone Corp. Antibodies for RETN
ThermoFisher Antibody for RETN
LSBio Antibodies in human, mouse, rat for RETN

RETN Assay Products:

EMD Millipore Kits and Assays for the Analysis of RETN
OriGene Custom Assay Services for RETN
R&D Systems ELISAs for RETN (Resistin)         (see all)
GenScript Custom Assay Services for RETN
Enzo Life Sciences assays for RETN
Cloud-Clone Corp. ELISAs for RETN
Cloud-Clone Corp. CLIAs for RETN


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009714 Resistin

Graphical View of Domain Structure for InterPro Entry Q9HD89

ProtoNet protein and cluster: Q9HD89

1 Blocks protein domain: IPB009714 Resistin

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89
Similarity: Belongs to the resistin/FIZZ family


RETN for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RETN_HUMAN, Q9HD89
Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells.
Potentially links obesity to diabetes

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
     
RETN for ontologies           About GeneDecksing


Phenotypes:
     6 GenomeRNAi human phenotypes for RETN:
 Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/ 
 Decreased influenza A/WSN/33 r  Increased circadian period len 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Retn):
 adipose tissue  homeostasis/metabolism  liver/biliary system 

RETN for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RETN
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RETN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RETN
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RETN

miRNA
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Block miRNA regulation of human, mouse, rat RETN using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RETN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RETN
Predesigned siRNA for gene silencing in human, mouse, rat RETN

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RETN

Clone
Products:
     
OriGene clones in human, mouse for RETN (see all 7)
OriGene ORF clones in mouse, rat for RETN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RETN (NM_020415)
Sino Biological Human cDNA Clone for RETN
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETN

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RETN
Browse ESI BIO Cell Lines and PureStem Progenitors for RETN 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETN


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RETN_HUMAN, Q9HD89: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2
peroxisome2

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--
GO:0005634nucleus IEA--

RETN for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RETN About                                                                                                See pathways by source

SuperPathContained pathways About
1IL-9 Signaling Pathways
Adipocytokines and Insulin Signaling0.34
2Selected targets of ESR1
Selected targets of ESR1
3Selected targets of C EBPbeta
Selected targets of C EBPbeta
4Selected targets of C EBPalpha
Selected targets of C EBPalpha
5Adipogenesis
Adipogenesis

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for RETN
    Adipocytokines & Insulin Signaling


1 BioSystems Pathway for RETN
    Adipogenesis



    Pathway & Disease-focused RT2 Profiler PCR Arrays including RETN (see all 6): 
          Insulin Signaling Pathway in human mouse rat
          Cell Surface Markers in human mouse rat
          Insulin Resistance in human mouse rat
          Diabetes in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for RETN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RETN (Q9HD893 ENSP000002215154) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SF3A2Q154283, ENSP000002214944I2D: score=1 STRING: ENSP00000221494
About this table

Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007568aging IEA--
GO:0008150biological_process ND--
GO:0009612response to mechanical stimulus IEA--
GO:0010714positive regulation of collagen metabolic process IEA--
GO:0014911positive regulation of smooth muscle cell migration IEA--

RETN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RETN

Selected Novoseek inferred chemical compound relationships for RETN gene (see all 54)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 75.7 325 15983036 (6), 19435854 (6), 19130414 (5), 20154025 (5) (see all 99)
rosiglitazone 70.6 46 15741250 (5), 14671216 (4), 17287417 (3), 16254032 (2) (see all 21)
nash 60.3 8 18609175 (2), 16231590 (1), 19693638 (1), 16231364 (1) (see all 7)
lipid 56.6 80 19041881 (3), 17067553 (3), 16497175 (2), 19408174 (2) (see all 58)
cholesterol 55.1 59 17365928 (3), 15034607 (3), 12647275 (2), 19290012 (2) (see all 35)
thiazolidinedione 48.4 3 12660880 (1), 12482590 (1)
pioglitazone 48.4 12 16682836 (3), 16804048 (2), 16118250 (1), 18359318 (1) (see all 6)
metformin 48 12 18446452 (2), 16118250 (1), 15736108 (1), 17224000 (1) (see all 7)
c-peptide 46.1 18 19430715 (3), 19693538 (2), 17010469 (2), 17287417 (1) (see all 11)
fatty acid 42 17 18499762 (2), 20514986 (2), 16685503 (1), 16497175 (1) (see all 14)



RETN for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RETN gene (2 alternative transcripts): 
NM_001193374.1  NM_020415.3  

Unigene Cluster for RETN:

Resistin
Hs.283091  [show with all ESTs]
Unigene Representative Sequence: EL736366
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000221515(uc002mhg.1 uc002mhf.1 uc010dvm.1) ENST00000381324

miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate RETN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RETN
Predesigned siRNA for gene silencing in human, mouse, rat RETN
Clone
Products:
     
OriGene clones in human, mouse for RETN (see all 7)
OriGene ORF clones in mouse, rat for RETN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RETN (NM_020415)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETN
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RETN
OriGene qSTAR qPCR primer pairs in human, mouse for RETN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RETN
  QuantiTect SYBR Green Assays in human, mouse, rat RETN
  QuantiFast Probe-based Assays in human, mouse, rat RETN

Additional mRNA sequence: 

AB111910.1 AF205952.1 AF290874.1 AF323081.1 AY207314.1 AY359066.1 BC069302.1 BC101554.1 
BC101560.1 

2 DOTS entries:

DT.441806  DT.92423483 

15 AceView cDNA sequences:

AB111910 BC069302 AF323081 AY207314 AF205952 AF290874 NM_020415 BM723331 
AY359066 BF590745 AA311223 BF002026 BX282116 BM682332 N41594 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RETN    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:                                    
SP2:        -                           


ECgene alternative splicing isoforms for RETN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RETN expression in normal human tissues (normalized intensities)      RETN embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACTGGACCG
RETN Expression
About this image


RETN expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Body Subcutaneous White Adipose
 
 Neurons
         Mature Rod Bipolar Cells Inner Nuclear Layer
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Blood (Hematopoietic System)
         Monocytes Peripheral Blood
 
 Eye (Sensory Organs)
         Mature Rod Bipolar Cells Inner Nuclear Layer
RETN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RETN Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.283091

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89
Tissue specificity: Expressed only in fatty tissues

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RETN (see all 6): 
          Insulin Signaling Pathway in human mouse rat
          Cell Surface Markers in human mouse rat
          Insulin Resistance in human mouse rat
          Diabetes in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RETN
OriGene qSTAR qPCR primer pairs in human, mouse for RETN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RETN
QuantiTect SYBR Green Assays in human, mouse, rat RETN
QuantiFast Probe-based Assays in human, mouse, rat RETN
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RETN gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Retn1 , 5 resistin1, 5 68.5(n)1
58.24(a)1
  8 (1.92 cM)5
572641  NM_022984.41  NP_075360.11 
 36557705 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
41(a)
40(a)
many ↔ many
many ↔ many
2(102944753-102953351)
2(102964086-102969981)


ENSEMBL Gene Tree for RETN (if available)
TreeFam Gene Tree for RETN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RETN gene
RETNLB2  
2 SIMAP similar genes for RETN using alignment to 2 protein entries:     RETN_HUMAN (see all proteins):
RELM-beta    RETNLB

RETN for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RETN (see all 128)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1810026031,2
--7401831(+) CATGGG/TGACAG 2 -- us2k10--------
rs1160890921,2
F--7401876(+) ATGGAC/TGGCAG 2 -- us2k11Minor allele frequency- T:0.04WA 118
rs1397425031,2
C--7401981(+) AATCCC/TGGCAC 2 -- us2k10--------
rs1843869891,2
C--7402114(+) TGTAAC/TCCCAG 2 -- us2k10--------
rs362041101,2
C--7402198(+) ACTGTA/GCTCCA 2 -- us2k10--------
rs124590441,2
C,F,H--7402205(+) tccagC/Gctgag 2 -- us2k14Minor allele frequency- G:0.18NA 126
rs1892709911,2
--7402218(+) ACTGAA/GTGAGA 2 -- us2k10--------
rs362041121,2
C,F--7402224(+) TGAGAC/TTCTGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
rs362044041,2
C,F--7402265(+) AATGGA/GACAAG 2 -- us2k11Minor allele frequency- G:0.06WA 118
rs340516861,2
--7402370(+) GACCCC/TGTCTC 2 -- us2k10--------

HapMap Linkage Disequilibrium report for RETN (7733930 - 7735340 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RETN:    About this table    
Variant IDTypeSubtypePubMed ID
nsv910970CNV Loss21882294
nsv833731CNV Loss17160897
esv2751809CNV Gain17911159

Human Gene Mutation Database (HGMD): RETN
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RETN
DNA2.0 Custom Variant and Variant Library Synthesis for RETN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605565   
OMIM disorders: 125853  
Selected diseases for RETN (see all 112):    About MalaCards
hypertension, insulin resistance-related    acquired generalized lipodystrophy    lipoatrophic diabetes    diabetes mellitus, noninsulin-dependent
idiopathic recurrent pericarditis    fatty liver disease    tumor necrosis factor receptor-associated periodic syndrome    nonalcoholic steatohepatitis
hyperthyroidism    glucose intolerance    uremia    end stage renal failure
gestational diabetes    lipodystrophy    bulimia nervosa    obesity, association with
familial partial lipodystrophy    anorexia nervosa    acute pancreatitis    polycystic ovary syndrome

8 diseases from the University of Copenhagen DISEASES database for RETN:
Diabetes mellitus     Atherosclerosis     Fatty liver disease     Hyperglycemia
Hypertension     Polycystic ovary syndrome     Hyperinsulinism     Heart disease

RETN for disorders           About GeneDecksing

Selected Novoseek inferred disease relationships for RETN gene (see all 81)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance 91.5 452 17716671 (5), 17366001 (5), 15111497 (4), 14651328 (4) (see all 99)
obesity 86.1 235 17366001 (5), 16080635 (4), 20346233 (3), 12429047 (3) (see all 99)
insulin sensitivity 84.8 107 16525810 (4), 18230823 (3), 17366001 (3), 18308111 (3) (see all 73)
niddm 71.4 24 14521723 (2), 15034607 (2), 17565416 (1), 12647275 (1) (see all 19)
acquired generalized lipodystrophy 70.8 1 15256772 (1)
inflammation 67.7 185 17366001 (5), 15034607 (5), 18234104 (4), 18709689 (4) (see all 96)
atherosclerosis 66.6 63 18710472 (4), 15710760 (3), 18023360 (2), 16271710 (2) (see all 45)
cardiovascular diseases 65.2 31 18220599 (2), 17175295 (1), 18446183 (1), 19223612 (1) (see all 23)
necrosis 65.2 176 16825020 (2), 19539174 (2), 17882804 (2), 17295762 (2) (see all 99)
fatty liver 64.6 14 19693638 (2), 16284427 (2), 16989692 (1), 18752757 (1) (see all 12)

Genetic Association Database (GAD): RETN
Human Genome Epidemiology (HuGE) Navigator: RETN (76 documents)

Export disorders for RETN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RETN gene, integrated from 10 sources (see all 1011):
(articles sorted by number of sources associating them with RETN)
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  1. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. (PubMed id 12050208)1, 3, 4 Wang H....Elbein S.C. (J. Clin. Endocrinol. Metab. 2002)
  2. Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. (PubMed id 19074981)1, 4, 9 Hivert M.F....Florez J.C. (Diabetes 2009)
  3. Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. (PubMed id 19269054)1, 4, 9 Tsukahara T....Nakamura J. (Diabetes Res. Clin. Pract. 2009)
  4. Analysis of genetic variations in the resistin gene shows no associations with obesity in women. (PubMed id 18239575)1, 4, 9 Beckers S....Van Hul W. (Obesity (Silver Spring) 2008)
  5. Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. (PubMed id 16675483)1, 4, 9 Escobar-Morreale H.F....San MillA!n J.L. (Hum. Reprod. 2006)
  6. Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians. (PubMed id 18710472)1, 4, 9 Qasim A.N....Reilly M.P. (Clin. Endocrinol. (Oxf) 2009)
  7. [Role of resistin in insulin resistance]. (PubMed id 18800626)1, 4, 9 Onuma H....Makino H. (Rinsho Byori 2008)
  8. [Polymorphisms of adiponectin and resistin genes in patients with obesity and anorexia nervosa]. (PubMed id 16921786)1, 4, 9 DolinkovA! M....HaluzA-k M. (Cas. Lek. Cesk. 2006)
  9. Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients. (PubMed id 15842513)1, 4, 9 Kunnari A....KesAoniemi Y.A. (Diabet. Med. 2005)
  10. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. (PubMed id 19727657)1, 4, 9 Asano H....Yokota M. (Diabetologia 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56729 HGNC: 20389 AceView: RETN Ensembl:ENSG00000104918 euGenes: HUgn56729
ECgene: RETN H-InvDB: RETN

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RETN Pharmacogenomics, SNPs, Pathways
NIEHS-SNPshttp://egp.gs.washington.edu/data/retn/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RETN gene:
Search GeneIP for patents involving RETN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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