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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RETN Gene

protein-coding   GIFtS: 60
GCID: GC19P007733

Resistin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
resistin1 2     ADSF2 3
FIZZ32 3 5     RETN12
RSTN2 3 5     XCP12
Adipose Tissue-Specific Secretory Factor2 3     C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein
Precursor 12
C/EBP-Epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein2 3     Found In Inflammatory Zone 32
Cysteine-Rich Secreted Protein A12-Alpha-Like 22 3     Resistin Delta22
Cysteine-Rich Secreted Protein FIZZ32 3     HXCP13

External Ids:    HGNC: 203891   Entrez Gene: 567292   Ensembl: ENSG000001049187   OMIM: 6055655   UniProtKB: Q9HD893   

Export aliases for RETN gene to outside databases

Previous GC identifers: GC19P007838 GC19P007628 GC19P007639 GC19P007403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RETN Gene:
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this
family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is
secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2010)

GeneCards Summary for RETN Gene: 
RETN (resistin) is a protein-coding gene. Diseases associated with RETN include lipoatrophic diabetes, and acquired generalized lipodystrophy, and among its related super-pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. GO annotations related to this gene include hormone activity. An important paralog of this gene is RETNLB.

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89
Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells.
Potentially links obesity to diabetes

Gene Wiki entry for RETN (Resistin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_077812.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RETN gene promoter:
         Elk-1   AML1a   AP-1   p300   ATF-2   MEF-2A   IRF-2   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRETN promoter sequence
   Search SABiosciences Chromatin IP Primers for RETN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RETN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RETN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RETN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007733:  view genomic region     (about GC identifiers)

Start:
7,733,930 bp from pter      End:
7,735,340 bp from pter
Size:
1,411 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89 (See protein sequence)
Recommended Name: Resistin precursor  
Size: 108 amino acids; 11419 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for RETN:
1LV6 (3D)    
Secondary accessions: D6W649 Q540D9

Explore the universe of human proteins at neXtProt for RETN: NX_Q9HD89

Explore proteomics data for RETN at MOPED 

RETN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RETN Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001180303.1  NP_065148.1  

ENSEMBL proteins: 
 ENSP00000221515   ENSP00000370725  

Human Recombinant Protein Products for RETN: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for RETN (Resistin)
Enzo Life Sciences proteins for RETN
OriGene Purified Protein for RETN
OriGene Protein Over-expression Lysate for RETN
OriGene MassSpec for RETN 
OriGene Custom Protein Services for RETN
GenScript Custom Purified and Recombinant Proteins Services for RETN
Novus Biologicals RETN Proteins
Novus Biologicals RETN Lysates
Sino Biological Recombinant Protein for RETN
Sino Biological Cell Lysate for RETN 
ProSpec Recombinant Protein for RETN
Cloud-Clone Corp. Proteins for RETN 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS--
GO:0005615extracellular space IEA--
GO:0005634nucleus IEA--

RETN for ontologies           About GeneDecksing



RETN Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of RETN
R&D Systems Antibodies for RETN (Resistin)
OriGene Antibodies for RETN
OriGene Custom Antibody Services for RETN
GenScript Custom Superior Antibodies Services for RETN
Novus Biologicals RETN Antibodies
Abcam antibodies for RETN
Cloud-Clone Corp. Antibodies for RETN 
ThermoFisher Antibody for RETN
LSBio Antibodies in human, mouse, rat for RETN 

Assay Products for RETN: 
EMD Millipore Kits and Assays for the Analysis of RETN
OriGene Custom Assay Services for RETN
R&D Systems ELISAs for RETN (Resistin)         (see all)
GenScript Custom Assay Services for RETN
Enzo Life Sciences assays for RETN
Cloud-Clone Corp. ELISAs for RETN 
Cloud-Clone Corp. CLIAs for RETN


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR009714 Resistin

Graphical View of Domain Structure for InterPro Entry Q9HD89

ProtoNet protein and cluster: Q9HD89

1 Blocks protein domain: IPB009714 Resistin

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89
Similarity: Belongs to the resistin/FIZZ family


RETN for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RETN_HUMAN, Q9HD89
Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells.
Potentially links obesity to diabetes

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity NAS--
     
RETN for ontologies           About GeneDecksing


Phenotypes:
     6 GenomeRNAi human phenotypes for RETN:
 Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/ 
 Decreased influenza A/WSN/33 r  Increased circadian period len 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Retn):
 adipose tissue  homeostasis/metabolism  liver/biliary system 

RETN for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for RETN 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RETN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RETN 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RETN 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RETN
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RETN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for RETN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETN

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RETN
Sirion Biotech Customized adenovirus for overexpression of RETN

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for RETN (see all 7)
OriGene ORF clones in mouse, rat for RETN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RETN (NM_020415)
Sino Biological Human cDNA Clone for RETN
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETN
Sirion Biotech Customized lentivirus for stable overexpression of RETN 
                     Customized lentivirus expression plasmids for stable overexpression of RETN 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RETN
Search LifeMap BioReagents cell lines for RETN
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETN


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RETN About                                                                                                See pathways by source

SuperPathContained pathways About
1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
Adipocytokines & Insulin Signaling0.34
2Selected targets of ESR1
Selected targets of ESR1
3Selected targets of C/EBPbeta
Selected targets of C/EBPbeta
4Adipogenesis
Adipogenesis
5Selected targets of C/EBPalpha
Selected targets of C/EBPalpha

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 EMD Millipore Pathways for RETN
    Selected targets of C/EBPbeta
Selected targets of ESR1
Selected targets of C/EBPalpha

1 R&D Systems Pathway for RETN
    Adipocytokines & Insulin Signaling


1 BioSystems Pathway for RETN
    Adipogenesis




RETN for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RETN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RETN (Q9HD893 ENSP000002215154) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SF3A2Q154283, ENSP000002214944I2D: score=1 STRING: ENSP00000221494
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--
GO:0032868response to insulin stimulus IEA--
GO:0045444fat cell differentiation IEA--

RETN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RETN for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RETN

10/54 Novoseek inferred chemical compound relationships for RETN gene (see all 54)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 75.7 325 15983036 (6), 19435854 (6), 19130414 (5), 20154025 (5) (see all 99)
rosiglitazone 70.6 46 15741250 (5), 14671216 (4), 17287417 (3), 16254032 (2) (see all 21)
nash 60.3 8 18609175 (2), 16231590 (1), 19693638 (1), 16231364 (1) (see all 7)
lipid 56.6 80 19041881 (3), 17067553 (3), 16497175 (2), 19408174 (2) (see all 58)
cholesterol 55.1 59 17365928 (3), 15034607 (3), 12647275 (2), 19290012 (2) (see all 35)
thiazolidinedione 48.4 3 12660880 (1), 12482590 (1)
pioglitazone 48.4 12 16682836 (3), 16804048 (2), 16118250 (1), 18359318 (1) (see all 6)
metformin 48 12 18446452 (2), 16118250 (1), 15736108 (1), 17224000 (1) (see all 7)
c-peptide 46.1 18 19430715 (3), 19693538 (2), 17010469 (2), 17287417 (1) (see all 11)
fatty acid 42 17 18499762 (2), 20514986 (2), 16685503 (1), 16497175 (1) (see all 14)

Search CenterWatch for drugs/clinical trials and news about RETN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RETN gene (2 alternative transcripts): 
NM_001193374.1  NM_020415.3  

Unigene Cluster for RETN:

Resistin
Hs.283091  [show with all ESTs]
Unigene Representative Sequence: EL736366
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000221515(uc002mhg.1 uc002mhf.1 uc010dvm.1) ENST00000381324

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RETN
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RETN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for RETN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RETN
Clone
Products:
     
OriGene clones in human, mouse for RETN (see all 7)
OriGene ORF clones in mouse, rat for RETN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RETN (NM_020415)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RETN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RETN
Sirion Biotech Customized lentivirus for stable overexpression of RETN 
                     Customized lentivirus expression plasmids for stable overexpression of RETN 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RETN
OriGene qSTAR qPCR primer pairs in human, mouse for RETN
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RETN
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETN
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETN

Additional mRNA sequence: 

AB111910.1 AF205952.1 AF290874.1 AF323081.1 AY207314.1 AY359066.1 BC069302.1 BC101554.1 
BC101560.1 

2 DOTS entries:

DT.441806  DT.92423483 

15 AceView cDNA sequences:

AB111910 BC069302 AF323081 AY207314 NM_020415 AF205952 AF290874 AY359066 
AA311223 BX282116 BM723331 BM682332 BF002026 BF590745 N41594 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RETN    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:                                    
SP2:        -                           


ECgene alternative splicing isoforms for RETN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RETN expression in normal human tissues (normalized intensities)      RETN embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACTGGACCG
RETN Expression
About this image


RETN expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 4 entries
         Monocytes Peripheral Blood
         bone marrow mononuclear cells   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone Marrow
         bone marrow   
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Body Subcutaneous White Adipose
 
 Lung (Respiratory System)
         alveolar macrophages   
 
 Eye (Sensory Organs)
         Mature Rod Bipolar Cells Inner Nuclear Layer

See RETN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RETN

SOURCE GeneReport for Unigene cluster: Hs.283091

UniProtKB/Swiss-Prot: RETN_HUMAN, Q9HD89
Tissue specificity: Expressed only in fatty tissues

    SABiosciences Expression via Pathway-Focused PCR Arrays including RETN (see all 6): 
          Insulin Signaling Pathway in human mouse rat
          Cell Surface Markers in human mouse rat
          Insulin Resistance in human mouse rat
          Diabetes in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RETN
OriGene qSTAR qPCR primer pairs in human, mouse for RETN
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RETN
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RETN
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RETN
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RETN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RETN gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Retn1 , 5 resistin1, 5 67.95(n)1
55.77(a)1
  8 (1.92 cM)5
572641  NM_001204959.11  NP_001191888.11 
 36557705 
lizard
(Anolis carolinensis)
Reptilia --
--
--
39(a)
39(a)
many ↔ many
many ↔ many
2(102944753-102953351)
2(102964086-102969981)


ENSEMBL Gene Tree for RETN (if available)
TreeFam Gene Tree for RETN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RETN gene
RETNLB2  
2 SIMAP similar genes for RETN using alignment to 2 protein entries:     RETN_HUMAN (see all proteins):
RELM-beta    RETNLB

RETN for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/128 SNPs in RETN are shown (see all 128)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1810026031,2
--7401831(+) CATGGG/TGACAG 2 -- us2k10--------
rs1160890921,2
F--7401876(+) ATGGAC/TGGCAG 2 -- us2k11Minor allele frequency- T:0.04WA 118
rs1397425031,2
C--7401981(+) AATCCC/TGGCAC 2 -- us2k10--------
rs1843869891,2
C--7402114(+) TGTAAC/TCCCAG 2 -- us2k10--------
rs362041101,2
C--7402198(+) ACTGTA/GCTCCA 2 -- us2k10--------
rs124590441,2
C,F,H--7402205(+) tccagC/Gctgag 2 -- us2k14Minor allele frequency- G:0.18NA 126
rs1892709911,2
--7402218(+) ACTGAA/GTGAGA 2 -- us2k10--------
rs362041121,2
C,F--7402224(+) TGAGAC/TTCTGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
rs362044041,2
C,F--7402265(+) AATGGA/GACAAG 2 -- us2k11Minor allele frequency- G:0.06WA 118
rs340516861,2
--7402370(+) GACCCC/TGTCTC 2 -- us2k10--------

HapMap Linkage Disequilibrium report for RETN (7733930 - 7735340 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RETN:    About this table     
Variant IDTypeSubtypePubMed ID
nsv910970CNV Loss21882294
nsv833731CNV Loss17160897
esv2751809CNV Gain17911159

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing RETN
DNA2.0 Custom Variant and Variant Library Synthesis for RETN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605565   
OMIM disorders: 125853  
20/109 diseases for RETN (see all 109):    About MalaCards
lipoatrophic diabetes    acquired generalized lipodystrophy    hypertension, insulin resistance-related    fatty liver disease
nonalcoholic steatohepatitis    obesity, association with    glucose intolerance    hyperthyroidism
uremia    familial partial lipodystrophy    polycystic ovary syndrome    diabetic angiopathy
bulimia nervosa    hyperandrogenism    anorexia nervosa    obesity
end stage renal failure    lipodystrophy    insulin resistance    moyamoya disease

8 diseases from the University of Copenhagen DISEASES database for RETN:
Diabetes mellitus     Atherosclerosis     Fatty liver disease     Hyperglycemia
Hypertension     Polycystic ovary syndrome     Hyperinsulinism     Heart disease

RETN for disorders           About GeneDecksing

10/81 Novoseek inferred disease relationships for RETN gene (see all 81)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance 91.5 452 17716671 (5), 17366001 (5), 15111497 (4), 14651328 (4) (see all 99)
obesity 86.1 235 17366001 (5), 16080635 (4), 20346233 (3), 12429047 (3) (see all 99)
insulin sensitivity 84.8 107 16525810 (4), 18230823 (3), 17366001 (3), 18308111 (3) (see all 73)
niddm 71.4 24 14521723 (2), 15034607 (2), 17565416 (1), 12647275 (1) (see all 19)
acquired generalized lipodystrophy 70.8 1 15256772 (1)
inflammation 67.7 185 17366001 (5), 15034607 (5), 18234104 (4), 18709689 (4) (see all 96)
atherosclerosis 66.6 63 18710472 (4), 15710760 (3), 18023360 (2), 16271710 (2) (see all 45)
cardiovascular diseases 65.2 31 18220599 (2), 17175295 (1), 18446183 (1), 19223612 (1) (see all 23)
necrosis 65.2 176 16825020 (2), 19539174 (2), 17882804 (2), 17295762 (2) (see all 99)
fatty liver 64.6 14 19693638 (2), 16284427 (2), 16989692 (1), 18752757 (1) (see all 12)

Genetic Association Database (GAD): RETN
Human Genome Epidemiology (HuGE) Navigator: RETN (76 documents)

Export disorders for RETN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RETN gene, integrated from 9 sources (see all 995):
(articles sorted by number of sources associating them with RETN)
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  1. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. (PubMed id 12050208)1, 3, 4 Wang H....Elbein S.C. (2002)
  2. Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. (PubMed id 19074981)1, 4, 9 Hivert M.F....Florez J.C. (2009)
  3. Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. (PubMed id 19269054)1, 4, 9 Tsukahara T....Nakamura J. (2009)
  4. Analysis of genetic variations in the resistin gene shows no associations with obesity in women. (PubMed id 18239575)1, 4, 9 Beckers S....Van Hul W. (2008)
  5. Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. (PubMed id 16675483)1, 4, 9 Escobar-Morreale H.F....San Millan J.L. (2006)
  6. [Role of resistin in insulin resistance] (PubMed id 18800626)1, 4, 9 Onuma H....Makino H. (2008)
  7. Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in non-diabetic caucasians. (PubMed id 18710472)1, 4, 9 Qasim A.N....Reilly M.P. (2008)
  8. [Polymorphisms of adiponectin and resistin genes in patients with obesity and anorexia nervosa] (PubMed id 16921786)1, 4, 9 Dolinkova M....Haluzik M. (2006)
  9. Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients. (PubMed id 15842513)1, 4, 9 Kunnari A....Kesaniemi Y.A. (2005)
  10. Plasma resistin concentration determined by common va riants in the resistin gene and associated with metabolic traits in an aged Jap anese population. (PubMed id 19727657)1, 4, 9 Asano H....Yokota M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56729 HGNC: 20389 AceView: RETN Ensembl:ENSG00000104918 euGenes: HUgn56729
ECgene: RETN H-InvDB: RETN

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RETN Pharmacogenomics, SNPs, Pathways
NIEHS-SNPshttp://egp.gs.washington.edu/data/retn/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RETN gene:
Search GeneIP for patents involving RETN

GeneCards and IP:
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