Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RET Gene

protein-coding   GIFtS: 76
GCID: GC10P043572

Ret Proto-Oncogene

(Previous names: multiple endocrine neoplasia and medullary thyroid carcinoma...)
(Previous symbols: HSCR1, MEN2A, MTC1, MEN2B)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ret Proto-Oncogene1 2     RET512 3
HSCR11 2 5     EC 2.7.10.13 8
MEN2A1 2 5     Hirschsprung Disease 11
MEN2B1 2     Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 11
MTC11 2     RET-ELE12
Cadherin-Related Family Member 161 2     Hydroxyaryl-Protein Kinase2
Cadherin Family Member 122 3     Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret2
Proto-Oncogene C-Ret2 3     Receptor Tyrosine Kinase2
CDHF122 3     Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid
Carcinoma 1, Hirschsprung Disease)2
CDHR162 3     RET Transforming Sequence2
PTC2 3     EC 2.7.108

External Ids:    HGNC: 99671   Entrez Gene: 59792   Ensembl: ENSG000001657317   OMIM: 1647615   UniProtKB: P079493   

Export aliases for RET gene to outside databases

Previous GC identifers: GC10P042861 GC10P043040 GC10P043347 GC10P042856 GC10P042892 GC10P040098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RET Gene:
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are
cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role
in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic
rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA,
multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript
variants encoding different isoforms have been found for this gene. Additional transcript variants have been
described but their biological validity has not been confirmed. (provided by RefSeq, Jul 2008)

GeneCards Summary for RET Gene: 
RET (ret proto-oncogene) is a protein-coding gene. Diseases associated with RET include multiple endocrine neoplasia, and hirschsprung's disease, and among its related super-pathways are G-protein signaling H-RAS regulation pathway and Development EGFR signaling pathway. GO annotations related to this gene include protein tyrosine kinase activity and calcium ion binding. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: RET_HUMAN, P07949
Function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation,
neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic
factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional
information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the
development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation
of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell
adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g.
ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of
ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a
dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and
down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor
survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several
diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell
migration

Gene Wiki entry for RET (RET proto-oncogene) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_033985.7  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RET gene promoter:
         NF-1   NF-1/L   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRET promoter sequence
   Search SABiosciences Chromatin IP Primers for RET

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RET


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.2

RET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RET gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P043572:  view genomic region     (about GC identifiers)

Start:
43,572,475 bp from pter      End:
43,625,799 bp from pter
Size:
53,325 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RET_HUMAN, P07949 (See protein sequence)
Recommended Name: Proto-oncogene tyrosine-protein kinase receptor Ret precursor  
Size: 1114 amino acids; 124319 Da
Subunit: Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5. The phosphorylated form
interacts with PLCG1 and GRB7 (By similarity). Interacts (not phosphorylated) with CC PTK2/FAK1 (via FERM
domain). Extracellular cell-membrane anchored RET cadherin fragments form complex in neurons with reduced trophic
status, preferentially at the contact sites between somas. Interacts with AIP in the pituitary gland; this
interaction prevents the formation of the AIP-survivin complex. Binds to ARTN
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I
membrane protein
Miscellaneous: Treatment with withaferin A (WA) leads tumor regression in medullary thyroid carcinomas (MTC)
Sequence caution: Sequence=AAA36524.1; Type=Erroneous initiation; Sequence=AAA36786.1; Type=Erroneous initiation;
Sequence=CAA33787.1; Type=Erroneous initiation; Sequence=CAC14882.1; Type=Erroneous initiation;
6/9 PDB 3D structures from and Proteopedia for RET (see all 9):
1XPD (3D)        2IVS (3D)        2IVT (3D)        2IVU (3D)        2IVV (3D)        2X2K (3D)    
Secondary accessions: A8K6Z2 Q15250 Q9BTB0 Q9H4A2
Alternative splicing: 2 isoforms:  P07949-1   P07949-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RET: NX_P07949

Explore proteomics data for RET at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation. Dephosphorylated by PTPRJ on Tyr-905,
    Tyr-1015 and Tyr-1062
  • UniProtKB: Proteolytically cleaved by caspase-3. The soluble RET kinase fragment is able to induce cell death. The
    extracellular cell-membrane anchored RET cadherin fragment accelerates cell adhesion in sympathetic neurons
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07949

  • 3 DME Specific Peptides for RET (P07949)
     RDLAARN  VAVKMLK  WMAIESL 

    RET Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RET Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_065681.1  NP_066124.1  

    ENSEMBL proteins: 
     ENSP00000347942   ENSP00000419080   ENSP00000344798  

    Human Recombinant Protein Products for RET: 
    EMD Millipore Purified and/or Recombinant RET Protein
    R&D Systems Recombinant & Natural Proteins for RET
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RET
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RET
    GenScript Custom Purified and Recombinant Proteins Services for RET
    Novus Biologicals RET Proteins
    Novus Biologicals RET Lysates
    Sino Biological Recombinant Protein for RET
    Sino Biological Cell Lysate for RET 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RET 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA19823924
    GO:0010008endosome membrane IDA19823924
    GO:0016020membrane ----

    RET for ontologies           About GeneDecksing



    RET Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RET
    R&D Systems Antibodies for RET
    Cell Signaling Technology (CST) Antibodies for RET 
    OriGene Antibodies for RET
    OriGene Custom Antibody Services for RET
    GenScript Superior Antibodies for RET
    Novus Biologicals RET Antibodies
    Abcam antibodies for RET
    Cloud-Clone Corp. Antibodies for RET 
    ThermoFisher Antibody for RET
    LSBio Antibodies in human, mouse, rat for RET 

    Assay Products for RET: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RET
    R&D Systems ELISAs for RET         (see all)
    GenScript RET-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RET
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RET 
    Cloud-Clone Corp. CLIAs for RET


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDHR: Cadherins / Cadherin-related

    IUPHAR Guide to PHARMACOLOGY protein family classification: ret proto-oncogene 
    Ret family

    5/9 InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR015919 Cadherin-like
     IPR000719 Prot_kinase_cat_dom
     IPR016249 Tyr_kinase_Ret_rcpt

    Graphical View of Domain Structure for InterPro Entry P07949

    ProtoNet protein and cluster: P07949

    2 Blocks protein domains:
    IPB002126 Cadherin
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RET_HUMAN, P07949
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 cadherin domain
    Similarity: Contains 1 protein kinase domain


    RET for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RET_HUMAN, P07949
    Function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation,
    neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic
    factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional
    information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the
    development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation
    of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell
    adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g.
    ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of
    ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a
    dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and
    down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor
    survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several
    diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell
    migration
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Repressed by 4-(3-hydroxyanilino)-quinolines derivatives, indolin-2-one-derivatives,
    2-(alkylsulfanyl)-4-(3-thienyl) nicotinonitrile analogs, 3- and 4-substituted beta-carbolin-1-ones, vandetanib,
    motesanib, sorafenib (BAY 43-9006), cabozantinib (XL184), sunitinib, and withaferin A (WA). Inactivation by
    sorafenib both reduces kinase activity and promotes lysosomal degradation
    Induction: Positively regulated by NKX2-1, PHOX2B, SOX10 and PAX3

         Genatlas biochemistry entry for RET:
    glial cell line derived neurotrophic factor (GDNF) receptor component,homodimerizing and binding the GDNF-GFRA
    complex,expressed in the developing kidney,the presumptive enteric neuroblats,cranial ganglia (VII,VIII,IX and X)
    and in the presumptive motor neurons of the spinal cord,interacting with SHC1 transduction adaptor
    protein,potentially involved in peripheral nerve repair

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS7824936
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0004872receptor activity TAS7824936
    GO:0005509calcium ion binding IDA11445581
         
    RET for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RET:
     Increased colony dispersion (i  Increased mitotic index 

         15/20 MGI mutant phenotypes (inferred from 42 alleles(MGI details for Ret) (see all 20):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  muscle  nervous system  no phenotypic analysis 

    RET for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RET: Rettm1.1Ddg Rettm1Cos Rettm1.1Kln Rettm1.2Pern Rettm6.2Vpa Rettm13.1Jmi

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RET 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RET

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RET 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RET 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RET:
    hsa-mir-29a (MIRT005908), hsa-mir-31 (MIRT004969)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RET
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate RET (see all 37):
    hsa-miR-136 hsa-miR-128 hsa-miR-449a hsa-miR-218 hsa-miR-570 hsa-miR-23a hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidRET 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RET
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RET

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RET
    Sirion Biotech Customized adenovirus for overexpression of RET

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RET (see all 12)
    OriGene ORF clones in mouse, rat for RET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RET (NM_020975)
    Sino Biological Human cDNA Clone for RET
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RET
    Sirion Biotech Customized lentivirus for stable overexpression of RET 
                         Customized lentivirus expression plasmids for stable overexpression of RET 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RET
    Search LifeMap BioReagents cell lines for RET
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RET


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RET About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-protein signaling H-RAS regulation pathway
    G-protein signaling H-RAS regulation pathway1.00
    2Development EGFR signaling pathway
    Development GDNF family signaling0.45
    3Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    4Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    5Thyroid cancer
    Thyroid cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for RET
        Development GDNF family signaling
    G-protein signaling H-RAS regulation pathway


    2 Cell Signaling Technology (CST) Pathways for RET
        Neuroscience
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for RET
        G-protein signaling H-RAS regulation pathway
    Development GDNF family signaling

    2 BioSystems Pathways for RET
        SIDS Susceptibility Pathways
    Signaling events regulated by Ret tyrosine kinase


    1 PharmGKB Pathway for RET
        Sorafenib Pharmacodynamics

    3         Kegg Pathways  (Kegg details for RET):
        Endocytosis
    Pathways in cancer
    Thyroid cancer


    RET for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RET

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for RET (P079492, 3 ENSP000003479424) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293532, 3, ENSP000004013034MINT-60981 I2D: score=5 STRING: ENSP00000401303
    PLCG1P191742, 3, ENSP000002440074MINT-8034153 I2D: score=4 STRING: ENSP00000244007
    CBLP226812, 3, ENSP000002640334MINT-50071 MINT-60976 MINT-60969 MINT-50072 MINT-60970 MINT-60968 I2D: score=3 STRING: ENSP00000264033
    STAT3P407632, 3, ENSP000002646574MINT-8033149 MINT-8037607 I2D: score=3 STRING: ENSP00000264657
    FAUP355442, 3, ENSP000002792594MINT-60966 MINT-60965 I2D: score=2 STRING: ENSP00000279259
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0001657ureteric bud development IEA--
    GO:0001755neural crest cell migration IEA--
    GO:0001838embryonic epithelial tube formation IEA--
    GO:0006468protein phosphorylation TAS7824936

    RET for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RET for compounds           About GeneDecksing

    EMD Millipore small molecules for RET:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for RET

    Browse Tocris compounds for RET

    2 HMDB Compounds for RET    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 DrugBank Compounds for RET    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sorafenib-- 284461-73-0targetinhibitor16507829 17016424 15466206
    1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine-- --target--10592235
    4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE-- --target--10592235
    Cabozantinibcabozantinib s-malate (see all 2)849217-68-1targetantagonist21606412
    Ponatinib -- 943319-70-8targetinhibitor23526464
    Regorafenib-- 755037-03-7targetinhibitor--

    10/46 Novoseek inferred chemical compound relationships for RET gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83.5 488 7678053 (4), 8363602 (4), 11564708 (4), 8114938 (3) (see all 99)
    zd6474 77.5 25 19029224 (4), 18245671 (3), 20225331 (2), 15867345 (2) (see all 13)
    cysteine 58.5 100 16732321 (3), 20119574 (3), 9097963 (3), 12734540 (2) (see all 67)
    succinate 50.8 22 12419172 (1), 17264467 (1), 18334619 (1), 15988378 (1) (see all 17)
    sunitinib 48.7 9 19887470 (2), 19453268 (1), 17505827 (1), 19188185 (1) (see all 8)
    phosphotyrosine 41.1 7 16847065 (2), 8812115 (1), 10728700 (1), 18756447 (1) (see all 5)
    sodium iodide 32.1 1 17391636 (1)
    threonine 30.6 10 9075701 (4), 7559902 (1), 11356339 (1), 11351254 (1) (see all 7)
    methionine 29.6 6 7559902 (1), 11356339 (1), 11351254 (1), 8884827 (1) (see all 6)
    cipa 29.4 4 8957089 (1), 12652644 (1)

    Search CenterWatch for drugs/clinical trials and news about RET

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RET gene (4 alternative transcripts): 
    NM_020630.4  NM_020975.4  NM_000323.2  NM_020629.2  

    Unigene Cluster for RET:

    Ret proto-oncogene
    Hs.350321  [show with all ESTs]
    Unigene Representative Sequence: NM_020975
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355710(uc001jal.3) ENST00000498820 ENST00000340058(uc001jak.1 uc010qez.1)
    ENST00000479913

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RET
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate RET (see all 37):
    hsa-miR-136 hsa-miR-128 hsa-miR-449a hsa-miR-218 hsa-miR-570 hsa-miR-23a hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidRET 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RET
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RET
    Clone
    Products:
         
    OriGene clones in human, mouse for RET (see all 12)
    OriGene ORF clones in mouse, rat for RET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RET (NM_020975)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RET
    Sirion Biotech Customized lentivirus for stable overexpression of RET 
                         Customized lentivirus expression plasmids for stable overexpression of RET 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RET
    OriGene qSTAR qPCR primer pairs in human, mouse for RET
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RET
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RET
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RET

    Additional mRNA sequence: 

    AB698668.1 AB698669.1 AJ844649.1 AK291807.1 AK294827.1 BC003072.2 BC004257.1 X15262.1 
    Y12528.1 

    9 DOTS entries:

    DT.40222723  DT.121287046  DT.121287035  DT.95362735  DT.97823574  DT.95362738  DT.100783057  DT.100783060 
    DT.100807107 

    24/93 AceView cDNA sequences (see all 93):

    AL514642 NM_020975 H24996 AI167534 AI204150 AA716772 AI263439 BM664772 
    NM_020630 BX283511 BX353743 BF311917 BE261669 BX451803 BX332519 CD630508 
    BE313267 BU858188 BQ720918 CD630504 BM690055 F07297 BX332520 AI825524 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RET    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:                                                                                                                                            -         
    SP2:                                                                                                                                                      
    SP3:                                                  -     -     -     -     -     -     -     -     -                                                   
    SP4:        -     -     -     -     -     -     -     -                                                                                                   


    ECgene alternative splicing isoforms for RET

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RET expression in normal human tissues (normalized intensities)      RET embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RET Expression
    About this image


    RET expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
             mK3
             Renal progenitor cells (Urteric bud-like cells) ( Stepwise renal lineage differentiation...
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Neural Tube (Nervous System)
             spinal cord/lateral wall   

    See RET Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RET

    SOURCE GeneReport for Unigene cluster: Hs.350321
        SABiosciences Expression via Pathway-Focused PCR Array including RET: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RET
    OriGene qSTAR qPCR primer pairs in human, mouse for RET
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RET
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RET
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RET
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RET

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RET gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ret1 , 5 ret proto-oncogene1, 5 82.78(n)1
    83.47(a)1
      6 (55.86 cM)5
    197131  NM_009050.21  NP_033076.21 
     1181517485 
    chicken
    (Gallus gallus)
    Aves RET1 ret proto-oncogene 66.13(n)
    67.21(a)
      396107  NM_205190.1  NP_990521.1 
    lizard
    (Anolis carolinensis)
    Reptilia RET6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343233.1(583056-678251)
    African clawed frog
    (Xenopus laevis)
    Amphibia ret-A2 ret proto-oncogene 75.55(n)    AF286643.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ret12 receptor tyrosine kinase 77.47(n)   30512  AF007949.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tor3 eggshell pattern formation
    transmembrane receptor more
    49(a)
    (best of 2)
      43E12   --
    worm
    (Caenorhabditis elegans)
    Secernentea R151.43 Tyrosine kinase 39(a)
    (best of 13)
      III(7291720-7292812)   --


    ENSEMBL Gene Tree for RET (if available)
    TreeFam Gene Tree for RET (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RET gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  PDGFRA2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    18/66 SIMAP similar genes for RET using alignment to 14 protein entries:     RET_HUMAN (see all proteins) (see all similar genes):
    R11    RET proto-oncogene    ret    urf-ret    RET/PTC2    CCDC6-RETa
    CCDC6-RETc    R12    FLT3    FLT4    FLT1    NTRK1
    ROR1    IGF1R    INSR    NTRK3    ABL1    KIT

    RET for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: RET_HUMAN, P07949
    Polymorphism: The Cys-982 polymorphism may be associated with an increased risk for developing Hirschsprung
    disease


    10/1494 SNPs in RET are shown (see all 1494)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0094624
    Hirschsprung disease 1 (HSCR1)4--see VAR_0094622 F S mis40--------
    VAR_0063164
    Multiple neoplasia 2A (MEN2A)4--see VAR_0063162 C R mis40--------
    VAR_0094904
    Hirschsprung disease 1 (HSCR1)4--see VAR_0094902 L P mis40--------
    VAR_0063044
    Hirschsprung disease 1 (HSCR1)4--see VAR_0063042 P L mis40--------
    VAR_0671244
    Hirschsprung disease 1 (HSCR1)4--see VAR_0671242 Y C mis40--------
    VAR_0063264
    Pheochromocytoma (PCC)4--see VAR_0063262 C R mis40--------
    VAR_0063244
    Pheochromocytoma (PCC)4--see VAR_0063242 C F mis40--------
    VAR_0671124
    Hirschsprung disease 1 (HSCR1)4--see VAR_0671122 V M mis40--------
    VAR_0443984
    Renal adysplasia (RADYS)4--see VAR_0443982 P S mis40--------
    VAR_0417674
    A bladder transitional cell carcinoma sample4--see VAR_0417672 F Y mis40--------

    HapMap Linkage Disequilibrium report for RET (43572475 - 43625799 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RET:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522566CNV Loss19592680
    nsv522592CNV Loss19592680
    dgv644n71CNV Loss21882294
    nsv825350CNV Gain20364138
    esv275022CNV Gain+Loss21479260


    Locus Specific Mutation Databases (LSDB): RET
    5/10 SABiosciences Cancer Mutation PCR Assays for RET (see all 10):
    Cosmic IdAA Change
    966p.C634R
    964p.C630R
    1048p.E632_T636>SS
    21338p.E768D
    977p.A883F
    5/6 SABiosciences Cancer Mutation PCR Arrays containing RET (see all 6):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Lung and Colon Cancers (Expanded Panel) 384HT
    Thyroid Cancer
    Cancer Comprehensive Panel 384HT
    SeqTarget long-range PCR primers for resequencing RET
    DNA2.0 Custom Variant and Variant Library Synthesis for RET

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164761   
    OMIM disorders: 171400  155240  162300  209880  171300  191830  142623  
    UniProtKB/Swiss-Prot: RET_HUMAN, P07949
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease
    may be caused by mutations affecting the gene represented in this entry
  • Hirschsprung disease 1 (HSCR1) [MIM:142623]: A disorder of neural crest development characterized by
    absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital
    intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting,
    abdominal distention and failure to pass stool, to chronic constipation in the older child. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Medullary thyroid carcinoma (MTC) [MIM:155240]: Rare tumor derived from the C cells of the thyroid. Three
    hereditary forms are known, that are transmitted in an autosomal dominant fashion: (a) multiple neoplasia type 2A
    (MEN2A), (b) multiple neoplasia type IIB (MEN2B) and (c) familial MTC (FMTC), which occurs in 25-30% of MTC cases
    and where MTC is the only clinical manifestation. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Multiple neoplasia 2B (MEN2B) [MIM:162300]: Uncommon inherited cancer syndrome characterized by
    predisposition to MTC and phaeochromocytoma which is associated with marfanoid habitus, mucosal neuromas,
    skeletal and ophthalmic abnormalities, and ganglioneuromas of the intestine tract. Then the disease progresses
    rapidly with the development of metastatic MTC and a pheochromocytome in 50% of cases. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal
    medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and
    norepinephrine, is hypertension, which may be persistent or intermittent. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Multiple neoplasia 2A (MEN2A) [MIM:171400]: The most frequent form of medullary thyroid cancer (MTC). It
    is an inherited cancer syndrome characterized by MTC, phaeochromocytoma and/or hyperparathyroidism. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in
    disease pathogenesis. Chromosomal aberrations involving RET have been found in thyroid papillary carcinomas.
    Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene; inversion inv(10)(q11.2;q11.2) generates
    the RET/NCOA4 (PTC3) oncogene; translocation t(10;14)(q11;q32) with GOLGA5 generates the RET/GOLGA5 (PTC5)
    oncogene; translocation t(8;10)(p21.3;q11.2) with PCM1 generates the PCM1/RET fusion; translocation
    t(6;10)(p21.3;q11.2) with RFP generates the Delta RFP/RET oncogene; translocation t(1;10)(p13;q11) with TRIM33
    generates the TRIM33/RET (PTC7) oncogene; translocation t(7;10)(q32;q11) with TRIM24/TIF1 generates the
    TRIM24/RET (PTC6) oncogene. The PTC5 oncogene has been found in 2 cases of PACT in children exposed to
    radioactive fallout after Chernobyl. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary
    carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta
    TRIM27/RET oncogenes
  • Renal adysplasia (RADYS) [MIM:191830]: Renal agenesis refers to the absence of one (unilateral) or both
    (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases,
    including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe
    obstructive uropathy. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal
    control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A
    deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal
    responses to hypercapnia and hypoxemia. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 20/116 diseases for RET (see all 116):    About MalaCards
    multiple endocrine neoplasia    hirschsprung's disease    multiple endocrine neoplasia type 2a    familial medullary thyroid carcinoma
    renal agenesis    follicular thyroid carcinoma    thyroid cancer, childhood    sipple syndrome
    familial papillary thyroid carcinoma    thyroid medullary carcinoma    ret-related pheochromocytoma    ret-related renal adysplasia
    aganglionosis, total intestinal    unilateral renal dysplasia    ret-related hirschsprung disease    central hypoventilation syndrome
    hirschsprung disease type 3    papillary thyroid carcinoma    papillary carcinoma    pheochromocytoma

    12 diseases from the University of Copenhagen DISEASES database for RET:
    Thyroid cancer     Hirschsprung's disease     Autosomal dominant disease     Hyperparathyroidism
    Paraganglioma     Phaeochromocytoma     Hemangioma     Carcinoma
    Renal agenesis     Intestinal obstruction     Adenoma     Parathyroid adenoma

    RET for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for RET gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    men 2a 98.4 707 8849577 (6), 8556060 (6), 9620546 (5), 17573899 (5) (see all 99)
    thyroid carcinoma medullary 98 409 7627269 (5), 7864888 (3), 12694233 (3), 16451770 (3) (see all 99)
    multiple endocrine neoplasia 98 333 8895732 (2), 9067749 (2), 16343738 (2), 11103773 (2) (see all 99)
    thyroid carcinoma, familial medullary 97.6 140 11502806 (3), 14602786 (3), 10323403 (2), 8829625 (2) (see all 99)
    hirschsprung disease 95 341 9824583 (6), 17108762 (4), 11955539 (4), 9384613 (4) (see all 99)
    men 3 94.5 290 11245446 (8), 9620546 (5), 17573899 (5), 1979053 (4) (see all 99)
    thyroid papillary carcinoma 93 251 8626874 (5), 9589668 (4), 17718263 (4), 10337992 (4) (see all 99)
    pheochromocytoma 91.3 299 8912182 (7), 14739491 (7), 10953992 (5), 9761126 (5) (see all 99)
    germ-line mutation 85.7 62 8895732 (2), 19484261 (2), 9179691 (2), 16419493 (2) (see all 53)
    colonic aganglionosis 80.3 9 17640327 (1), 14715928 (1), 7478601 (1), 18081917 (1) (see all 9)

    GeneTests: RET
    GeneReviews: RET
    Genetic Association Database (GAD): RET
    Human Genome Epidemiology (HuGE) Navigator: RET (139 documents)
    Tumor Gene Database (TGDB): RET

    Export disorders for RET gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RET gene, integrated from 9 sources (see all 1610):
    (articles sorted by number of sources associating them with RET)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene. (PubMed id 10522989)1, 2, 4, 9 Tessitore A.... Colantuoni V. (1999)
    2. Germ-line mutations in nonsyndromic pheochromocytoma. (PubMed id 12000816)1, 2, 4, 9 Neumann H.P.H.... Eng C. (2002)
    3. TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease. (PubMed id 15548547)1, 4, 9 Garcia-Barcelo M....Tam P.K. (2005)
    4. A complex additive model of inheritance for Hirschsprung disease is supported by both RET mutations and predisposing RET haplotypes. (PubMed id 17108762)1, 4, 9 Ruiz-Ferrer M....Borrego S. (2006)
    5. Hirschsprung disease in MEN 2A: increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation. (PubMed id 9384613)1, 2, 9 Decker R.A.... Watson P. (1998)
    6. Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas. (PubMed id 19401695)1, 4, 9 Moura M.M....Leite V. (2009)
    7. Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. (PubMed id 18073307)1, 4, 9 Elisei R....Pinchera A. (2008)
    8. RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population. (PubMed id 15240649)1, 4, 9 Elisei R....Pinchera A. (2004)
    9. Identification of RET autophosphorylation sites by mass spectrometry. (PubMed id 14711813)1, 2, 9 Kawamoto Y.... Nakashima I. (2004)
    10. Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site. (PubMed id 10484767)1, 2, 9 Geneste O.... Billaud M. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5979 HGNC: 9967 AceView: RET Ensembl:ENSG00000165731 euGenes: HUgn5979
    ECgene: RET Kegg: 5979 H-InvDB: RET

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RET Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RET Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RET
    MEN2 RET databasehttp://www.arup.utah.edu/database/MEN2/MEN2_welcome.php

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RET gene:
    Search GeneIP for patents involving RET

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Purified and/or Recombinant RET Protein
     EMD Millipore small molecules (inhibitor) for RET
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RET
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RET (Ret)   Browse Cell Culture Products  
     ELISAs for RET (Ret)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for RET (Ret)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for RET (Ret)   Proteome Profiler Antibody Arrays for RET (Ret)  
     OriGene Antibodies for RET   OriGene RNAi products in human, mouse, rat for RET  
     OriGene qPCR primer pairs and template standards for RET   OriGene Protein Over-expression Lysate for RET  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RET  
     OriGene qSTAR qPCR primer pairs in human, mouse for RET   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RET   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RET   OriGene Custom Protein Services for RET  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RET
     QIAGEN SeqTarget long-range PCR primers for resequencing RET
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RET
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RET
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RET
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RET
     GenScript Custom Purified and Recombinant Proteins Services for RET GenScript cDNA clones with any tag delivered in your preferred vector for RET
     GenScript RET-Activity-based Kinase Assay for Compound Screening GenScript Superior Antibodies for RET
     GenScript Custom overexpressing Cell Line Services for RET CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RET 

     Regulatory tfbs in RET promoter
     Search Chromatin IP Primers for RET
     RT2 qPCR Primer Assay in human, mouse, rat RET
     GNC Network for RET
     SABiosciences PCR Arrays including human, mouse, rat RET
     Search Tocris compounds for RET
     Proteins and Antibodies for RET
     Cell Lysates for RET
     cDNA Clones for RET
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for RET
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RET antibodies
     RET proteins
     RET lysates
     Antibodies for RET
     See all of Abcam's Antibodies, Kits and Proteins for RET
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RET
     Antibodies for RET
     ELISAs for RET
     CLIAs for RET
     Search LifeMap BioReagents cell lines for RET
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RET
     SwitchGear 3'UTR luciferase reporter plasmids for RET
     SwitchGear Promoter luciferase reporter plasmids for RET
     ThermoFisher Antibody for RET
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RET
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RET
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RET
    Customized:
     lentivirus for stable overexpression of RET
     lentivirus expression plasmids for stable overexpression of RET
     adenovirus for overexpression of RET
     LSBio Antibodies in human, mouse, rat for RET
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RET gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4