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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REST Gene

protein-coding   GIFtS: 64
GCID: GC04P057689

RE1-silencing transcription factor
 Explore 23 diseases affiliated with
REST via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for REST    

Aliases
for REST gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RE1-Silencing Transcription Factor1 2     Neuron Restrictive Silencer Factor2
NRSF1 2 3 5     Repressor Binding To The X2 Box2
XBR1 2 3     X2 Box Repressor3
Neural-Restrictive Silencer Factor2 3     

External Ids:    HGNC: 99661   Entrez Gene: 59782   Ensembl: ENSG000000840937   OMIM: 6005715   UniProtKB: Q131273   

Export aliases for REST gene to outside databases

Previous GC identifers: GC04P057577 GC04P057730 GC04P057614 GC04P057468 GC04P053727


Summaries
for REST gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for REST:
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of
the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element
called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor
cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively
spliced transcript variants have been described (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: REST_HUMAN, Q13127
Function: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene
transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct
corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes.
Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating
specific sites on histones, thereby acting as a chromatin modifier

Gene Wiki entry for REST (RE1-silencing transcription factor)


Genomic Views
for REST gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REST gene promoter:
         CREB   POU2F1   POU2F1a   NRSF form 1   deltaCREB   Lmo2   NRSF form 2   C/EBPalpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: REST promoter sequence
   Search SABiosciences Chromatin IP Primers for REST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

REST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REST gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P057689:  view genomic region     (about GC identifiers)

Start:
 57,774,042 bp from pter      End:
 57,802,010 bp from pter
Size:
 27,969 bases      Orientation:
 plus strand

Proteins
for REST gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: REST_HUMAN, Q13127 (See protein sequence)
Recommended Name: RE1-silencing transcription factor  
Size: 1097 amino acids; 121872 Da
Subunit: Interacts with SIN3A, SIN3B and RCOR1
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAA98503.1; Type=Frameshift; Positions=188, 198, 202, 212, 1087; Sequence=AAC50114.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAC50115.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=AAH38985.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Potential poly-A sequence; Sequence=BAD92987.1; Type=Erroneous initiation; Note=Translation N-terminally
shortened;
1 PDB 3D structure from and Proteopedia for REST:
2CZY (3D)    
Secondary accessions: A2RUE0 B9EGJ0 Q12956 Q12957 Q13134 Q59ER1 Q8IWI3
Alternative splicing: 4 isoforms:  Q13127-1   Q13127-2   Q13127-3   Q13127-4   

Explore the universe of human proteins at neXtProt for REST: NX_Q13127

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13127

    • REST Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180437.1  NP_005603.3  

    ENSEMBL proteins: 
     ENSP00000311816  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: REST
    OriGene Custom Protein Services for REST 
    GenScript Custom Purified and Recombinant Proteins Services for REST
    Novus Biologicals REST Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for REST

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ----
    GO:0005634nucleus NAS7871435
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--


    REST for ontologies           About GeneDecksing



    REST Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of REST
    Browse R&D Systems for Antibodies
    OriGene Antibodies: REST
    OriGene Custom Antibody Services for REST 
    GenScript Superior Antibodies for REST
    Novus Biologicals REST Antibodies
    Abcam antibodies for REST 
    Uscn Antibodies for REST
    ThermoFisher Antibodies for REST

    Assay Products for REST: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REST
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for REST

    Protein Domains /
    Families
    for REST gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    REST for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13127

    ProtoNet protein and cluster: Q13127

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: REST_HUMAN, Q13127
    Similarity: Contains 9 C2H2-type zinc fingers


    Function
    for REST gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: REST_HUMAN, Q13127
    Function: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene
    transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct
    corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes.
    Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating
    specific sites on histones, thereby acting as a chromatin modifier

         Genatlas biochemistry entry for REST:
    RE1 silencing transcription factor

    miRNA
    Products:            		miRTarBase miRNAs that target REST:
    hsa-mir-9 (MIRT000026), hsa-mir-21 (MIRT000177)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REST
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate REST (see all 80):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-219-5p hsa-miR-3142 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REST (see all 7)
    OriGene shRNA RFP: REST
    OriGene siRNA: REST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REST

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for REST

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REST (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REST (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): REST (NM_005612)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REST 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for REST
    Search LifeMap BioReagents cell lines for REST

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REST

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding IDA8568247
    GO:0001047core promoter binding IDA17984088
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding ISS--


    REST for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for REST:
     Increased cell transformation 

    Animal Models:
         Mouse knock-outs for REST: Resttm1.2Yasu Resttm1And Resttm1Ymat
         7 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Rest):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 
     reproductive system  vision/eye 

    REST for phenotypes           About GeneDecksing


    Pathways & Interactions
    for REST gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription_Sin3 and NuRD in transcription regulation
    		Transcription_Sin3 and NuRD in transcription regulation1.00
    		Transcription Sin3 and NuRD in transcription regulation0.96
    2Dichloroethylene metabolism
    		Dichloroethylene metabolism1.00
    		Dichloroethylene metabolism1.00
    3Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00
    4Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00
    5SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for REST
        Dichloroethylene metabolism
    Selected targets of Oct-3/4
    Transcription Sin3 and NuRD in transcription regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for REST
        Transcriptional Regulatory Network in Embryonic Stem Cell
    WNT Signaling

    2 GeneGo (Thomson Reuters) Pathways for REST
        Transcription Sin3 and NuRD in transcription regulation
    Dichloroethylene metabolism

    1 BioSystems Pathway for REST 
        SIDS Susceptibility Pathways


    1         Kegg Pathway  (Kegg details for REST):
        Huntington's disease


    REST for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for REST (Q131271, 3 ENSP000003118164) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMARCA4P515321, 3, ENSP000003507204EBI-926706,EBI-302489 I2D: score=2 STRING: ENSP00000350720
    HDAC4P565243, ENSP000002646064I2D: score=2 STRING: ENSP00000264606
    NANOGQ9H9S03, ENSP000002293074I2D: score=2 STRING: ENSP00000229307
    RCOR1Q9UKL03, ENSP000002622414I2D: score=2 STRING: ENSP00000262241
    HTTP428583, ENSP000003471844I2D: score=1 STRING: ENSP00000347184
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7697725
    GO:0006355regulation of transcription, DNA-dependent NAS7871435
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0010629negative regulation of gene expression IMP--
    GO:0032348negative regulation of aldosterone biosynthetic process IMP19342457


    REST for ontologies           About GeneDecksing



    Drugs & Compounds
    for REST gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    REST for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REST
    8 Novoseek chemical compound relationships for REST gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 40 13 11741002 (2), 10521596 (1), 12220737 (1), 11703459 (1) (see all 7)
    nmda 6.51 4 15755907 (2), 10640675 (1)
    kainate 6.39 5 16701950 (4)
    sodium 0 1 14561745 (1)
    calcium 0 1 19426709 (1)
    tyrosine 0 2 16764822 (1), 9648849 (1)
    arginine 0 1 12220737 (1)
    glutamate 0 1 16701950 (1)

    Search CenterWatch for drugs/clinical trials and news about REST 

    Transcripts
    for REST gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for REST gene (2 alternative transcripts): 
    NM_001193508.1  NM_005612.4  

    Unigene Cluster for REST:

    RE1-silencing transcription factor
    Hs.307836  [show with all ESTs]
    Unigene Representative Sequence: NM_005612
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309042(uc003hch.3 uc003hci.3 uc010ihf.3) ENST00000511065
    ENST00000503522 ENST00000514063

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REST
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate REST (see all 80):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-219-5p hsa-miR-3142 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REST (see all 7)
    OriGene shRNA RFP: REST
    OriGene siRNA: REST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REST
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REST (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REST (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): REST (NM_005612)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REST 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REST
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REST
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REST
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REST

    Additional cDNA sequence: 

    AB209750.1 AF228045.1 BC017822.1 BC038985.1 BC132859.1 BC136491.1 JX896957.1 JX896958.1 
    JX896959.1 JX896960.1 JX896961.1 JX896962.1 JX896963.1 JX896964.1 JX896965.1 JX896966.1 
    JX896967.1 JX896968.1 JX896969.1 JX896970.1 JX896971.1 JX896972.1 JX896973.1 JX896974.1 
    JX896975.1 JX896976.1 JX896977.1 JX896978.1 JX896979.1 JX896980.1 JX896981.1 JX896982.1 
    JX896983.1 JX896984.1 JX896985.1 JX896986.1 JX896987.1 JX896988.1 JX896989.1 JX896990.1 
    JX896991.1 JX896992.1 JX896993.1 KC117262.1 KC117263.1 KC117264.1 KC117265.1 KC117266.1 
    U13877.1 U13879.1 U22314.1 

    7 DOTS entries:

    DT.100878061  DT.97842965  DT.101977160  DT.40248261  DT.95159023  DT.91776459  DT.91776455 

    24/163 AceView cDNA sequences (see all 163):

    CB135540 AI122873 CA312250 AW468023 AI693146 CA432947 AL044868 AU134037 
    CA396786 AW665998 AW057857 AI124003 AW207586 BC017822 AW627549 AA897328 
    AW068887 H82188 AA300694 BE856589 BE466700 AI419921 BQ422139 AW102731 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for REST    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:        -                       -               
    SP2:                                -               
    SP3:                                                


    ECgene alternative splicing isoforms for REST

    Expression
    for REST gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCCTGTGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    REST expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeNeuroblastic LayerEarly Retinal Progenitor CellsRetina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See REST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REST

    SOURCE GeneReport for Unigene cluster: Hs.307836

    UniProtKB/Swiss-Prot: REST_HUMAN, Q13127
    Tissue specificity: Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including
    spleen, thymus, peripheral blood lymphocytes and ovary

        SABiosciences Expression via Pathway-Focused PCR Arrays including REST: 
              Embryonic Stem Cells in human mouse rat
              Huntington's Disease in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REST
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REST
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REST
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REST
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REST

    Orthologs
    for REST gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for REST gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rest1 , 5 RE1-silencing transcription factor1, 5 75.31(n)1
    70.81(a)1    		   5 (41.61 cM)5
    197121  NM_011263.21  NP_035393.21 
     772654915 
    chicken
    (Gallus gallus)    		 Aves REST1 RE1-silencing transcription factor 64.49(n)
    62.27(a)    		   422623  XM_420580.3  XP_420580.3 
    lizard
    (Anolis carolinensis)    		 Reptilia REST6
    		 --
    		 50(a)
    		 1 ↔ 1
    		 GL343257.1(1801780-1812871)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rest-A2 RE1-silencing transcription factor 78.78(n)    AF096301.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rest1 RE1-silencing transcription factor 50.95(n)
    44.74(a)    		   564772  XM_001922872.2  XP_001922907.1 


    ENSEMBL Gene Tree for REST (if available)
    TreeFam Gene Tree for REST (if available) 

    Paralogs
    for REST gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REST gene
    ZNF4072  
    18/39 SIMAP similar genes for REST using alignment to 16 protein entries:     REST_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    kr-znf3    DKFZp686N0199    ZNF808    ZNF    ZNF55
    HZF17    ZNF702P    ZNF72    smap-7    ZNF22    ZNF663
    ZNF697    A-328A3.4    DKFZp313M0722    DKFZp434J0650    DKFZp547H249    HZF16

    REST for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for REST
    PGOHUM00000239869


    Genomic Variants
    for REST gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for REST
         1 CNV: 68729
    Human Gene Mutation Database (HGMD): REST
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REST
    DNA2.0 Custom Variant and Variant Library Synthesis for REST

    Disorders / Diseases
    for REST gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    REST for disorders           About GeneDecksing

    OMIM gene information: 600571    OMIM disorders: --

    20/23 diseases for REST (see all 23):    About MalaCards
    pneumatosis cystoides intestinalis    neuronitis    major depressive disorder    relapsing fever
    fg syndrome    myotilinopathy    rhabdoid tumors    down syndrome
    herpes simplex    lyme disease    pheochromocytoma    medulloblastoma
    huntington's disease    lung cancer    noma    aldosteronism
    ovarian cancer    lung carcinoma    breast cancer    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for REST:
    Pneumatosis cystoides intestinalis     Huntington's disease

    7 Novoseek disease relationships for REST gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    medulloblastoma 32.3 5 16823502 (2), 19150961 (1)
    small cell lung cancer 28.2 6 10766169 (2), 12220737 (1), 14741407 (1)
    pheochromocytoma 18.4 1 18485095 (1)
    glioma 4.8 5 16823502 (4)
    down syndrome 0 2 11830198 (1), 15068239 (1)
    tumors 0 8 15960972 (2), 16929174 (2), 18818083 (1), 19846118 (1) (see all 6)
    cancer 0 4 15960972 (1), 18354483 (1), 16823502 (1)

    Human Genome Epidemiology (HuGE) Navigator: REST (298 documents)

    Export disorders for REST gene to outside databases

    Publications
    for REST gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REST gene, integrated from 9 sources (see all 185):
    (articles sorted by number of sources associating them with REST)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. (PubMed id 7871435)1, 2, 3, 9 Schoenherr C.J. and Anderson D.J. (1995)
    2. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. (PubMed id 7697725)1, 2, 3 Chong J.A.... Mandel G. (1995)
    3. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. (PubMed id 10521596)1, 2, 9 Palm K.... Timmusk T. (1999)
    4. The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. (PubMed id 16288918)1, 2, 9 Nomura M.... Nishimura Y. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. (PubMed id 12399542)1, 2 Lunyak V.V....Rosenfeld M.G. (2002)
    7. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. (PubMed id 10734093)1, 2 Grimes J.A.... Kouzarides T. (2000)
    8. CoREST: a functional corepressor required for regulation of neural- specific gene expression. (PubMed id 10449787)1, 2 Andres M.E.... Mandel G. (1999)
    9. A zinc finger protein that represses transcription of the human MHC class II gene, DPA. (PubMed id 8568247)1, 2 Scholl T.... Strominger J.L. (1996)
    10. SCFbeta-TRCP controls oncogenic transformation and ne ural differentiation through REST degradation. (PubMed id 18354483)1, 9 Westbrook T.F....Elledge S.J. (2008)

    External Searches for REST gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing REST gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5978 HGNC: 9966 AceView: REST Ensembl:ENSG00000084093 euGenes: HUgn5978
    ECgene: REST Kegg: 5978 H-InvDB: REST

    Other Databases showing REST gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing REST gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REST Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for REST gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for REST gene:
    Search GeneIP for patents involving REST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for REST gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REST
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     Regulatory tfbs in REST promoter
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     REST Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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