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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REST Gene

protein-coding   GIFtS: 64
GCID: GC04P057689

RE1-Silencing Transcription Factor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RE1-Silencing Transcription Factor1 2     Neuron Restrictive Silencer Factor2
NRSF2 3 5     Repressor Binding To The X2 Box2
Neural-Restrictive Silencer Factor2 3     X2 Box Repressor3
XBR2 3     

External Ids:    HGNC: 99661   Entrez Gene: 59782   Ensembl: ENSG000000840937   OMIM: 6005715   UniProtKB: Q131273   

Export aliases for REST gene to outside databases

Previous GC identifers: GC04P057577 GC04P057730 GC04P057614 GC04P057468 GC04P053727


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REST Gene:
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a
member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA
sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated
neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of
neurogenesis. Alternatively spliced transcript variants have been described (provided by RefSeq, Jul 2010)

GeneCards Summary for REST Gene: 
REST (RE1-silencing transcription factor) is a protein-coding gene. Diseases associated with REST include pneumatosis cystoides intestinalis, and myotilinopathy, and among its related super-pathways are Dichloroethylene metabolism and Parkinson's disease. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF407.

UniProtKB/Swiss-Prot: REST_HUMAN, Q13127
Function: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal
gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two
distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of
REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by
deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier

Gene Wiki entry for REST (RE1-silencing transcription factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022853.15  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REST gene promoter:
         CREB   POU2F1   POU2F1a   NRSF form 1   deltaCREB   Lmo2   NRSF form 2   C/EBPalpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREST promoter sequence
   Search SABiosciences Chromatin IP Primers for REST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

REST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REST gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P057689:  view genomic region     (about GC identifiers)

Start:
57,774,042 bp from pter      End:
57,802,010 bp from pter
Size:
27,969 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REST_HUMAN, Q13127 (See protein sequence)
Recommended Name: RE1-silencing transcription factor  
Size: 1097 amino acids; 121872 Da
Subunit: Interacts with SIN3A, SIN3B and RCOR1
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAA98503.1; Type=Frameshift; Positions=188, 198, 202, 212, 1087; Sequence=AAC50114.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAC50115.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=AAH38985.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAD92987.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for REST:
2CZY (3D)    
Secondary accessions: A2RUE0 B9EGJ0 Q12956 Q12957 Q13134 Q59ER1 Q8IWI3
Alternative splicing: 4 isoforms:  Q13127-1   Q13127-2   Q13127-3   Q13127-4   

Explore the universe of human proteins at neXtProt for REST: NX_Q13127

Explore proteomics data for REST at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13127

  • REST Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REST Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180437.1  NP_005603.3  

    ENSEMBL proteins: 
     ENSP00000311816  

    Human Recombinant Protein Products for REST: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for REST
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for REST
    GenScript Custom Purified and Recombinant Proteins Services for REST
    Novus Biologicals REST Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REST 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7871435
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0017053transcriptional repressor complex IDA10734093

    REST for ontologies           About GeneDecksing



    REST Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of REST
    Browse R&D Systems for Antibodies
    OriGene Antibodies for REST
    OriGene Custom Antibody Services for REST
    GenScript Superior Antibodies for REST
    Novus Biologicals REST Antibodies
    Abcam antibodies for REST
    Cloud-Clone Corp. Antibodies for REST 
    ThermoFisher Antibodies for REST
    LSBio Antibodies in human, mouse, rat for REST 

    Assay Products for REST: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for REST
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REST
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for REST 
    Cloud-Clone Corp. CLIAs for REST


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13127

    ProtoNet protein and cluster: Q13127

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: REST_HUMAN, Q13127
    Similarity: Contains 9 C2H2-type zinc fingers


    REST for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REST_HUMAN, Q13127
    Function: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal
    gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two
    distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of
    REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by
    deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier

         Genatlas biochemistry entry for REST:
    RE1 silencing transcription factor

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding IDA8568247
    GO:0001047core promoter binding IDA17984088
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA10449787
    GO:0003677DNA binding ----
    GO:0003682chromatin binding ISS--
         
    REST for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for REST:
     Increased cell transformation 

         7 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Rest):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 
     reproductive system  vision/eye 

    REST for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for REST: Resttm1.2Yasu Resttm1And Resttm1Ymat

       inGenious Targeting Laboratory - Custom generated mouse model solutions for REST 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REST 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REST 

    miRNA
    Products:
        
    miRTarBase miRNAs that target REST:
    hsa-mir-9 (MIRT000026), hsa-mir-21 (MIRT000177)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REST
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate REST (see all 80):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-219-5p hsa-miR-3142 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REST

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REST
    Sirion Biotech Customized adenovirus for overexpression of REST

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for REST (see all 7)
    OriGene ORF clones in mouse, rat for REST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): REST (NM_005612)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REST
    Sirion Biotech Customized lentivirus for stable overexpression of REST 
                         Customized lentivirus expression plasmids for stable overexpression of REST 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for REST
    Search LifeMap BioReagents cell lines for REST
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REST


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for REST About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Dichloroethylene metabolism
    Dichloroethylene metabolism1.00
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.47
    3Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35
    4Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    5Selected targets of Oct-3/4
    Selected targets of Oct-3/4

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for REST
        Dichloroethylene metabolism
    Selected targets of Oct-3/4
    Transcription Sin3 and NuRD in transcription regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for REST
        Transcriptional Regulatory Network in Embryonic Stem Cell
    WNT Signaling

    2 GeneGo (Thomson Reuters) Pathways for REST
        Transcription Sin3 and NuRD in transcription regulation
    Dichloroethylene metabolism

    1 BioSystems Pathway for REST
        SIDS Susceptibility Pathways


    1         Kegg Pathway  (Kegg details for REST):
        Huntington's disease


    REST for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for REST (Q131271, 3 ENSP000003118164) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMARCA4P515321, 3, ENSP000003507204EBI-926706,EBI-302489 I2D: score=2 STRING: ENSP00000350720
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000227333Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7697725
    GO:0006355regulation of transcription, DNA-dependent NAS7871435
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0010629negative regulation of gene expression IMP--
    GO:0032348negative regulation of aldosterone biosynthetic process IMP19342457

    REST for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    REST for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REST

    8 Novoseek inferred chemical compound relationships for REST gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 40 13 11741002 (2), 10521596 (1), 12220737 (1), 11703459 (1) (see all 7)
    nmda 6.51 4 15755907 (2), 10640675 (1)
    kainate 6.39 5 16701950 (4)
    sodium 0 1 14561745 (1)
    calcium 0 1 19426709 (1)
    tyrosine 0 2 16764822 (1), 9648849 (1)
    arginine 0 1 12220737 (1)
    glutamate 0 1 16701950 (1)

    Search CenterWatch for drugs/clinical trials and news about REST

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REST gene (2 alternative transcripts): 
    NM_001193508.1  NM_005612.4  

    Unigene Cluster for REST:

    RE1-silencing transcription factor
    Hs.307836  [show with all ESTs]
    Unigene Representative Sequence: NM_005612
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309042(uc003hch.3 uc003hci.3 uc010ihf.3) ENST00000511065
    ENST00000503522 ENST00000514063
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REST
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate REST (see all 80):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-219-5p hsa-miR-3142 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REST
    Clone
    Products:
         
    OriGene clones in human, mouse for REST (see all 7)
    OriGene ORF clones in mouse, rat for REST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): REST (NM_005612)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REST
    Sirion Biotech Customized lentivirus for stable overexpression of REST 
                         Customized lentivirus expression plasmids for stable overexpression of REST 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for REST
    OriGene qSTAR qPCR primer pairs in human, mouse for REST
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REST
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REST
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REST

    Additional mRNA sequence: 

    AB209750.1 AF228045.1 BC017822.1 BC038985.1 BC132859.1 BC136491.1 JX896957.1 JX896958.1 
    JX896959.1 JX896960.1 JX896961.1 JX896962.1 JX896963.1 JX896964.1 JX896965.1 JX896966.1 
    JX896967.1 JX896968.1 JX896969.1 JX896970.1 JX896971.1 JX896972.1 JX896973.1 JX896974.1 
    JX896975.1 JX896976.1 JX896977.1 JX896978.1 JX896979.1 JX896980.1 JX896981.1 JX896982.1 
    JX896983.1 JX896984.1 JX896985.1 JX896986.1 JX896987.1 JX896988.1 JX896989.1 JX896990.1 
    JX896991.1 JX896992.1 JX896993.1 KC117262.1 KC117263.1 KC117264.1 KC117265.1 KC117266.1 
    U13877.1 U13879.1 U22314.1 

    7 DOTS entries:

    DT.97842965  DT.100878061  DT.101977160  DT.40248261  DT.95159023  DT.91776459  DT.91776455 

    24/163 AceView cDNA sequences (see all 163):

    AW627549 AI510700 AI631845 BE466700 AI122873 AA897328 CB135540 AW207586 
    NM_005612 AA300694 AU134037 AI693146 AI671959 H82188 AA766208 AI419921 
    CA432947 BM551017 CA393464 CB131624 BQ422139 AI022988 AL044868 BM982215 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for REST    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:        -                       -               
    SP2:                                -               
    SP3:                                                


    ECgene alternative splicing isoforms for REST

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REST expression in normal human tissues (normalized intensities)      REST embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCTGTGAA
    REST Expression
    About this image


    REST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Olfactory Bulb   
     
     Epithelium
             vagina ; squamous epithelial cells   
             gingival epithelium   
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             t cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             gingival epithelium   

    See REST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REST

    SOURCE GeneReport for Unigene cluster: Hs.307836

    UniProtKB/Swiss-Prot: REST_HUMAN, Q13127
    Tissue specificity: Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment,
    including spleen, thymus, peripheral blood lymphocytes and ovary

        SABiosciences Expression via Pathway-Focused PCR Arrays including REST: 
              Embryonic Stem Cells in human mouse rat
              Huntington's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for REST
    OriGene qSTAR qPCR primer pairs in human, mouse for REST
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REST
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REST
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REST
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for REST gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rest1 , 5 RE1-silencing transcription factor1, 5 75.31(n)1
    70.81(a)1
      5 (41.61 cM)5
    197121  NM_011263.21  NP_035393.21 
     772654915 
    chicken
    (Gallus gallus)
    Aves REST1 RE1-silencing transcription factor 64.49(n)
    62.27(a)
      422623  XM_420580.3  XP_420580.3 
    lizard
    (Anolis carolinensis)
    Reptilia REST6
    Uncharacterized protein
    49(a)
    1 ↔ 1
    GL343257.1(1801780-1812871)
    African clawed frog
    (Xenopus laevis)
    Amphibia rest-A2 RE1-silencing transcription factor 78.78(n)    AF096301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rest1 RE1-silencing transcription factor 50.95(n)
    44.74(a)
      564772  XM_001922872.2  XP_001922907.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316126
    --
    4(a)
    1 → many
    2L(21762314-21795445)


    ENSEMBL Gene Tree for REST (if available)
    TreeFam Gene Tree for REST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REST gene
    ZNF4072  
    18/121 SIMAP similar genes for REST using alignment to 16 protein entries:     REST_HUMAN (see all proteins) (see all similar genes):
    ZNF148    ZNF79    ZNF500    ZNF768    ZNF420    ZNF112
    ZNF133    ZNF419    kr-znf3    ZNF213    ZNF544    ZNF83
    ZNF808    ATL1    ATL1-delta    HKR1    ZNF263    ZNF418

    REST for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for REST
    PGOHUM00000239869


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/741 SNPs in REST are shown (see all 741)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505905701,2
    --53755997(+) TTCACA/CCAAGA 2 -- ds50010--------
    rs774241671,2
    C,F--57677018(+) ATTTTC/AAATTG 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs124988101,2
    H--57677054(+) ACCTGT/GGGCCT 1 -- us2k1 tfbs34Minor allele frequency- G:0.00NS EA 418
    rs1917255451,2
    --57677071(+) CATGAC/TAATTT 1 -- us2k10--------
    rs1140348961,2
    F--57677148(+) CATTCG/ACCATT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1150575501,2
    F--57677175(+) AATATG/ATGGGA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs779911521,2
    C,F--57677285(+) TTGGAC/ACTAAA 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1432682051,2
    C--57677335(+) GTAGAA/GGCCTG 1 -- us2k10--------
    rs1129367831,2
    C--57677471(+) TCCCTC/-CCCTC 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1837360001,2
    --57677563(+) CCTCAC/TTGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for REST (57774042 - 57802010 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for REST:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663344CNV Deletion23128226
    esv22393CNV Loss19812545
    nsv822562CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600571    OMIM disorders: --

    20/24 diseases for REST (see all 24):    About MalaCards
    pneumatosis cystoides intestinalis    myotilinopathy    fg syndrome    relapsing fever
    rhabdoid tumor    lyme disease    major depressive disorder    down syndrome
    medulloblastoma    neuronitis    pheochromocytoma    huntington's disease
    lung cancer    age related macular degeneration    herpes simplex    neuroblastoma
    macular degeneration    mental retardation    cerebritis    glioblastoma

    1 disease from the University of Copenhagen DISEASES database for REST:
    Huntington's disease

    REST for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for REST gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    medulloblastoma 32.3 5 16823502 (2), 19150961 (1)
    small cell lung cancer 28.2 6 10766169 (2), 12220737 (1), 14741407 (1)
    pheochromocytoma 18.4 1 18485095 (1)
    glioma 4.8 5 16823502 (4)
    down syndrome 0 2 11830198 (1), 15068239 (1)
    tumors 0 8 15960972 (2), 16929174 (2), 18818083 (1), 19846118 (1) (see all 6)
    cancer 0 4 15960972 (1), 18354483 (1), 16823502 (1)

    Genetic Association Database (GAD): REST
    Human Genome Epidemiology (HuGE) Navigator: REST (298 documents)

    Export disorders for REST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REST gene, integrated from 9 sources (see all 198):
    (articles sorted by number of sources associating them with REST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. (PubMed id 7871435)1, 2, 3, 9 Schoenherr C.J. and Anderson D.J. (1995)
    2. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. (PubMed id 7697725)1, 2, 3 Chong J.A.... Mandel G. (1995)
    3. Additive effect of BDNF and REST polymorphisms is associated with improved general cognitive ability. (PubMed id 18518926)1, 4, 9 Miyajima F....Payton A. (2008)
    4. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. (PubMed id 10521596)1, 2, 9 Palm K.... Timmusk T. (1999)
    5. The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. (PubMed id 16288918)1, 2, 9 Nomura M.... Nishimura Y. (2005)
    6. Genome-wide association study identifies two susceptib ility loci for exudative age-related macular degeneration in the Japanese popula tion. (PubMed id 21909106)1, 4 Arakawa S....Kubo M. (2011)
    7. A genetic variant near the PMAIP1/Noxa gene is associ ated with increased bleomycin sensitivity. (PubMed id 21106707)1, 4 Gu J....Wu X. (2011)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. (PubMed id 12399542)1, 2 Lunyak V.V....Rosenfeld M.G. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5978 HGNC: 9966 AceView: REST Ensembl:ENSG00000084093 euGenes: HUgn5978
    ECgene: REST Kegg: 5978 H-InvDB: REST

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for REST Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REST gene:
    Search GeneIP for patents involving REST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Regulatory tfbs in REST promoter
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     Proteins for REST
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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