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Aliases for REST Gene

Aliases for REST Gene

  • RE1 Silencing Transcription Factor 2 3 5
  • RE1-Silencing Transcription Factor 2 3
  • Neural-Restrictive Silencer Factor 3 4
  • NRSF 3 4
  • XBR 3 4
  • RE1-Silencing Transcription Factor Variant E1a/E2k/E2i/E3/E4j 3
  • RE1-Silencing Transcription Factor Variant E1a/E2/E3/N3a/E4i 3
  • RE1-Silencing Transcription Factor Variant E1b/E2/E3/N3b/E4i 3
  • RE1-Silencing Transcription Factor Variant E1b/E2c/E2j/E3/E4 3
  • RE1-Silencing Transcription Factor Variant E1a/E2/E3/N3c/E4 3
  • RE1-Silencing Transcription Factor Variant E1b/E2/E3/N3c/E4 3
  • RE1-Silencing Transcription Factor Variant E1a/E2/E3/E4c 3
  • RE1-Silencing Transcription Factor Variant E1c/E2g/E3/E4 3
  • RE1-Silencing Transcription Factor Variant E1a/E2/E3/E5 3
  • RE1-Silencing Transcription Factor Variant E1b/E2/E3/E5 3
  • RE1-Silencing Transcription Factor Variant E1c/E2/E3/E5 3
  • RE1-Silencing Transcription Factor Variant E1a/E2a/E2k 3
  • RE1-Silencing Transcription Factor Variant E1a/E2d/E4g 3
  • RE1-Silencing Transcription Factor Variant E1a/E2e/E4h 3
  • RE1-Silencing Transcription Factor Variant E1a/E2f/E4e 3
  • RE1-Silencing Transcription Factor Variant E1b/E2a/E2k 3
  • RE1-Silencing Transcription Factor Variant E1b/E2e/E4h 3
  • RE1-Silencing Transcription Factor Variant E1c/E2a/E2k 3
  • RE1-Silencing Transcription Factor Variant E1a/E2/E4 3
  • RE1-Silencing Transcription Factor Variant E1a/E2/E5 3
  • Neuron-Restrictive Silencer Factor 2
  • Neuron Restrictive Silencer Factor 3
  • Repressor Binding To The X2 Box 3
  • X2 Box Repressor 4
  • WT6 3

External Ids for REST Gene

Previous GeneCards Identifiers for REST Gene

  • GC04P057577
  • GC04P057730
  • GC04P057689
  • GC04P057614
  • GC04P057468
  • GC04P053727
  • GC04P057774

Summaries for REST Gene

Entrez Gene Summary for REST Gene

  • This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

GeneCards Summary for REST Gene

REST (RE1 Silencing Transcription Factor) is a Protein Coding gene. Diseases associated with REST include Wilms Tumor 6 and Hereditary Wilms' Tumor. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is ZNF827.

UniProtKB/Swiss-Prot for REST Gene

  • Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Gene Wiki entry for REST Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REST Gene

Genomics for REST Gene

Regulatory Elements for REST Gene

Enhancers for REST Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G056975 1.4 Ensembl ENCODE 10.6 +71.8 71753 7.3 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ENSG00000269949 NOA1 RNU6-998P REST AASDH
GH04G056874 0.9 FANTOM5 ENCODE 13.4 -33.4 -33414 0.3 ZNF362 POLR2A POU5F1 PRDM10 ZNF384 REST SPINK2 ENSG00000251799 POLR2B NOA1 HOPX ENSG00000269949 PPAT GC04P056899
GH04G056799 1.1 Ensembl ENCODE 9.4 -107.7 -107743 1.5 ATF1 TBL1XR1 WRNIP1 ZNF48 RAD21 YY1 GATA2 ZNF143 RELB IKZF2 SPINK2 PPAT PAICS NOA1 POLR2B SRP72 REST ENSG00000269949 LOC105377668 GC04P056807
GH04G056836 0.9 Ensembl ENCODE 10.4 -71.1 -71076 0.4 CTCF ZNF654 TRIM22 REST RAD21 SMC3 HMBOX1 ZNF143 SRP72 REST HOPX PAICS PPAT AASDH SPINK2 GC04P056899
GH04G056870 0.7 Ensembl ENCODE 11.8 -36.6 -36551 1.9 PKNOX1 FOXP2 TRIM28 ENSG00000269949 REST SPINK2 ENSG00000251799 NOA1 POLR2B GC04P056899
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around REST on UCSC Golden Path with GeneCards custom track

Promoters for REST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168709 1024 3001 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF121 ZNF766 GLIS2 ELK1

Genomic Location for REST Gene

Chromosome:
4
Start:
56,907,876 bp from pter
End:
56,966,678 bp from pter
Size:
58,803 bases
Orientation:
Plus strand

Genomic View for REST Gene

Genes around REST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REST Gene

Proteins for REST Gene

  • Protein details for REST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13127-REST_HUMAN
    Recommended name:
    RE1-silencing transcription factor
    Protein Accession:
    Q13127
    Secondary Accessions:
    • A2RUE0
    • B9EGJ0
    • Q12956
    • Q12957
    • Q13134
    • Q59ER1
    • Q8IWI3

    Protein attributes for REST Gene

    Size:
    1097 amino acids
    Molecular mass:
    121872 Da
    Quaternary structure:
    • Interacts with SIN3A, SIN3B and RCOR1. Interacts with CDYL. Interacts with EHMT1 and EHMT2 only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Interacts (via zinc-finger DNA-binding domain) with ZFP90 (via N- and C-termini); the interaction inhibits REST repressor activity (PubMed:21284946).
    SequenceCaution:
    • Sequence=AAA98503.1; Type=Frameshift; Positions=188, 198, 202, 212, 1087; Evidence={ECO:0000305}; Sequence=AAC50114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC50115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH38985.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD92987.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REST Gene

    Alternative splice isoforms for REST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REST Gene

Post-translational modifications for REST Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for REST Gene

Domains & Families for REST Gene

Suggested Antigen Peptide Sequences for REST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with REST: view

No data available for Gene Families and UniProtKB/Swiss-Prot for REST Gene

Function for REST Gene

Molecular function for REST Gene

GENATLAS Biochemistry:
RE1 silencing transcription factor
UniProtKB/Swiss-Prot Function:
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Gene Ontology (GO) - Molecular Function for REST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0001046 core promoter sequence-specific DNA binding IDA 8568247
GO:0001047 core promoter binding IDA 17984088
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10449787
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with REST: view
genes like me logo Genes that share phenotypes with REST: view

Human Phenotype Ontology for REST Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for REST Gene

MGI Knock Outs for REST:

Animal Model Products

CRISPR Products

miRNA for REST Gene

miRTarBase miRNAs that target REST
Targeted motifs for REST Gene
HOMER Transcription Factor Regulatory Elements motif REST
  • Consensus sequence: GGAGCTGTCCATGGTGCTGA Submotif: canonical Cell Type: Jurkat

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for REST
  • Applied Biological Materials Clones for REST

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for REST Gene

Localization for REST Gene

Subcellular locations from UniProtKB/Swiss-Prot for REST Gene

Nucleus. Note=Colocalizes with ZFP90 in the nucleus. {ECO:0000250 UniProtKB:Q8VIG1}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REST gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for REST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IEA 7871435
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IEA --
GO:0017053 transcriptional repressor complex IDA 10734093
genes like me logo Genes that share ontologies with REST: view

Pathways & Interactions for REST Gene

genes like me logo Genes that share pathways with REST: view

Gene Ontology (GO) - Biological Process for REST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7697725
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7871435
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with REST: view

No data available for SIGNOR curated interactions for REST Gene

Drugs & Compounds for REST Gene

(6) Drugs for REST Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for REST Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with REST: view

Transcripts for REST Gene

Unigene Clusters for REST Gene

RE1-silencing transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for REST
  • Applied Biological Materials Clones for REST

Alternative Splicing Database (ASD) splice patterns (SP) for REST Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3:

Relevant External Links for REST Gene

GeneLoc Exon Structure for
REST
ECgene alternative splicing isoforms for
REST

Expression for REST Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REST Gene

Protein differential expression in normal tissues from HIPED for REST Gene

This gene is overexpressed in Serum (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REST Gene



Protein tissue co-expression partners for REST Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of REST Gene:

REST

SOURCE GeneReport for Unigene cluster for REST Gene:

Hs.307836

mRNA Expression by UniProt/SwissProt for REST Gene:

Q13127-REST_HUMAN
Tissue specificity: Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary.

Evidence on tissue expression from TISSUES for REST Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with REST: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for REST Gene

Orthologs for REST Gene

This gene was present in the common ancestor of animals.

Orthologs for REST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REST 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia REST 34 35
  • 85.9 (n)
cow
(Bos Taurus)
Mammalia REST 34
  • 85.15 (n)
-- 35
  • 75 (a)
OneToMany
MGC157163 35
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rest 34
  • 74.22 (n)
mouse
(Mus musculus)
Mammalia Rest 34 16 35
  • 73.08 (n)
oppossum
(Monodelphis domestica)
Mammalia REST 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REST 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves REST 34 35
  • 71.01 (n)
lizard
(Anolis carolinensis)
Reptilia REST 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10667 34
African clawed frog
(Xenopus laevis)
Amphibia rest-A 34
zebrafish
(Danio rerio)
Actinopterygii rest 35
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31612 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1932 35
  • 20 (a)
OneToOne
Species where no ortholog for REST was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for REST Gene

ENSEMBL:
Gene Tree for REST (if available)
TreeFam:
Gene Tree for REST (if available)

Paralogs for REST Gene

Paralogs for REST Gene

Pseudogenes.org Pseudogenes for REST Gene

genes like me logo Genes that share paralogs with REST: view

Variants for REST Gene

Sequence variations from dbSNP and Humsavar for REST Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs869025312 other, Wilms tumor 6 (WT6) [MIM:616806] 56,919,853(+) TAGAC(A/G)TATGC intron-variant, reference, missense
VAR_076333 Wilms tumor 6 (WT6) [MIM:616806]
VAR_076334 Wilms tumor 6 (WT6) [MIM:616806]
VAR_076336 Wilms tumor 6 (WT6) [MIM:616806]
rs869025310 other 56,911,469(+) TACAC(-/AT)GTGGA reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for REST Gene

Variant ID Type Subtype PubMed ID
dgv5214n100 CNV gain 25217958
esv22393 CNV loss 19812545
esv2663344 CNV deletion 23128226
nsv1074717 CNV deletion 25765185
nsv1114531 CNV deletion 24896259
nsv594205 CNV gain 21841781
nsv594206 CNV loss 21841781
nsv822562 CNV gain 20364138
nsv967748 CNV duplication 23825009

Variation tolerance for REST Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REST Gene

Human Gene Mutation Database (HGMD)
REST
SNPedia medical, phenotypic, and genealogical associations of SNPs for
REST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REST Gene

Disorders for REST Gene

MalaCards: The human disease database

(6) MalaCards diseases for REST Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wilms tumor 6
  • susceptibility to wilms tumor 6
hereditary wilms' tumor
  • hereditary wilms tumor
wilms tumor susceptibility-5
  • wilms tumor
myopathy, myofibrillar, 3
  • myofibrillar myopathy 3
huntington disease
  • congenital anomalies of kidney and urinary tract 2
- elite association - COSMIC cancer census association via MalaCards
Search REST in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

REST_HUMAN
  • Wilms tumor 6 (WT6) [MIM:616806]: A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells. {ECO:0000269 PubMed:26551668}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for REST

Genetic Association Database (GAD)
REST
Human Genome Epidemiology (HuGE) Navigator
REST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REST
genes like me logo Genes that share disorders with REST: view

No data available for Genatlas for REST Gene

Publications for REST Gene

  1. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. (PMID: 7871435) Schoenherr C.J. … Anderson D.J. (Science 1995) 2 3 4 22 64
  2. Additive effect of BDNF and REST polymorphisms is associated with improved general cognitive ability. (PMID: 18518926) Miyajima F. … Payton A. (Genes Brain Behav. 2008) 3 22 46 64
  3. The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. (PMID: 16288918) Nomura M. … Nishimura Y. (J. Mol. Biol. 2005) 3 4 22 64
  4. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. (PMID: 10521596) Palm K. … Timmusk T. (Brain Res. Mol. Brain Res. 1999) 3 4 22 64
  5. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. (PMID: 7697725) Chong J.A. … Mandel G. (Cell 1995) 2 3 4 64

Products for REST Gene

  • Addgene plasmids for REST

Sources for REST Gene

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